Search results for SHMT2
| Author | PMID | Outcome | Exposure | Tissue | Analysis | N | CpG | Location | Gene | Beta | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg06868473 | chr12:57622801 | SHMT2 | -0.0073 | 0E+00 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 6y with age as a fixed effect | 2338 | cg06868473 | chr12:57622801 | SHMT2 | 0.022 | 0E+00 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg08163918 | chr12:57628654 | SHMT2 | -0.0017 | 0E+00 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 6y with age as a fixed effect | 2338 | cg08163918 | chr12:57628654 | SHMT2 | 0.012 | 0E+00 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg25110782 | chr12:57624371 | SHMT2 | -0.0021 | 0E+00 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg03052162 | chr12:57622963 | SHMT2 | -0.57066 | 2.2E-171 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg12639933 | chr12:57626296 | SHMT2 | 0.4 | 6E-144 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg25110782 | chr12:57624371 | SHMT2 | 0.34 | 1.4E-131 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg11851129 | chr12:57624530 | SHMT2 | 0.16 | 1.8E-105 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg06868473 | chr12:57622801 | SHMT2 | -0.188 | 4.2E-100 |
| Xu CJ | 28056824 | DNA methylation | Age 4 vs age 0 | Whole blood and cord blood | - | 269 | cg06868473 | chr12:57622801 | SHMT2 | NA | 3.2E-96 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg08163918 | chr12:57628654 | SHMT2 | 0.22 | 2.2E-93 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg08163918 | chr12:57628654 | SHMT2 | NA | 1.5E-74 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg12502815 | chr12:57623997 | SHMT2 | 0.034 | 5.2E-69 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg12639933 | chr12:57626296 | SHMT2 | NA | 2.4E-60 |
| Bonder MJ | 25282492 | DNA methylation | Fetal vs adult liver | Liver | - | 195 | cg19535267 | chr12:57625610 | SHMT2 | 3.0 | 1.4E-47 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg19535267 | chr12:57625610 | SHMT2 | 0.037 | 7.3E-45 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg02773601 | chr12:57623994 | SHMT2 | 0.022 | 1.5E-44 |
| Bonder MJ | 25282492 | DNA methylation | Fetal vs adult liver | Liver | - | 195 | cg25110782 | chr12:57624371 | SHMT2 | 1.7 | 1.7E-40 |
| Bonder MJ | 25282492 | DNA methylation | Fetal vs adult liver | Liver | - | 195 | cg11851129 | chr12:57624530 | SHMT2 | 1.5 | 5.4E-38 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.100197 | 4.7E-34 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg08228578 | chr12:57624193 | SHMT2 | -4.6 | 3.6E-32 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg03052162 | chr12:57622963 | SHMT2 | NA | 1.3E-31 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | sensitivity | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.815835 | 9.1E-29 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg19535267 | chr12:57625610 | SHMT2 | NA | 7.2E-28 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.555705 | 5E-27 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.543322 | 5.1E-26 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.085 | 3.5E-25 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.083 | 1.4E-23 |
| Yao C | 33752734 | DNA methylation | Gene expression of Affymetrix ID: 3418007 (gene symbol: SHMT2) | Whole blood | Meta-analysis | 4170 | cg25110782 | chr12:57624371 | SHMT2 | NA | 2.9E-23 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg12502815 | chr12:57623997 | SHMT2 | 0.00047 | 2.2E-20 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | sensitivity | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.655082 | 2.5E-19 |
| Hannah M. Smith | 39706196 | DNA methylation | Waist-hip ratio | Whole blood | discovery | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.461431 | 3.2E-19 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.074 | 4.3E-19 |
| Hannah M. Smith | 39706196 | DNA methylation | Waist-hip ratio | Whole blood | sensitivity | 17304 | cg08228578 | chr12:57624193 | SHMT2 | -0.652461 | 4.4E-19 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.075 | 9.8E-19 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.071 | 4.7E-18 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg08228578 | chr12:57624193 | SHMT2 | -0.075 | 2.9E-17 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.071 | 4.5E-17 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.068 | 1.3E-16 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0657731 | 4.7E-15 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.064344 | 6.1E-15 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.064 | 1.4E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0651258 | 1.5E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.063 | 1.8E-14 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg01267941 | chr12:57623452 | SHMT2 | -5.7e-05 | 4.1E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.062 | 6.3E-14 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg03052162 | chr12:57622963 | SHMT2 | -0.00056 | 8.9E-14 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg27039453 | chr12:57623757 | SHMT2 | 0.0004 | 1.2E-13 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg23588553 | chr12:57623699 | SHMT2 | 0.013 | 3.8E-13 |
| Gadd DA | 35945220 | PSAT1 protein levels (SeqId = 18342-2) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.95 | 5.2E-13 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg01763913 | chr12:57623930 | SHMT2 | 0.0094 | 7.1E-13 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg11350278 | chr12:57623962 | SHMT2 | 0.0093 | 7.1E-13 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg21697007 | chr12:57623759 | SHMT2 | 0.0086 | 1.1E-12 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg19621579 | chr12:57623725 | SHMT2 | 0.01 | 1.2E-12 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg11851129 | chr12:57624530 | SHMT2 | -2.3 | 1.4E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P01042 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0891906 | 1.5E-12 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg12502815 | chr12:57623997 | SHMT2 | 0.00036 | 3.1E-12 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg03052162 | chr12:57622963 | SHMT2 | 0.016 | 3.6E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0571184 | 4.4E-12 |
| Xu K | 31386212 | DNA methylation | Alcohol Consumption | Saliva | adjusted for bmi | 1135 | cg08228578 | chr12:57624193 | SHMT2 | NA | 4.9E-12 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg11350278 | chr12:57623962 | SHMT2 | 0.00042 | 7.3E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.058 | 7.7E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P01042 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0561132 | 1E-11 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.055829 | 1.3E-11 |
| Kyung WK | 32795589 | DNA methylation | eosinophilia | nasal polyp | discovery | 129 | cg04213529 | chr12:57626075 | SHMT2 | -0.025 | 2E-11 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.056 | 3E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.055 | 3.2E-11 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg27039453 | chr12:57623757 | SHMT2 | 0.013 | 4.1E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0555429 | 5.5E-11 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg02773601 | chr12:57623994 | SHMT2 | 0.00045 | 6.7E-11 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0553385 | 7.1E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0551534 | 7.1E-11 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg10952910 | chr12:57623761 | SHMT2 | 0.00051 | 7.8E-11 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg26220528 | chr12:57623348 | SHMT2 | 0.0012 | 8.7E-11 |
| Xu K | 31386212 | DNA methylation | Alcohol Consumption | Saliva | not adjusted for bmi | 1135 | cg08228578 | chr12:57624193 | SHMT2 | NA | 8.9E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.055131 | 1E-10 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0532435 | 1.1E-10 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0531294 | 1.2E-10 |
| Dugue P-A | 31789449 | Alcohol consumption | DNA methylation | Whole blood | Previous week consumption discovery | 5606 | cg11851129 | chr12:57624530 | SHMT2 | NA | 1.4E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0784349 | 1.4E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0526716 | 1.7E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0526236 | 1.8E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04196 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.08 | 1.9E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04003 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0518561 | 3.3E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P01008 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.053 | 3.4E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0516616 | 3.8E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.05 | 1.1E-09 |
| Gadd DA | 35945220 | ACY1 protein levels (SeqId = 3343-1) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.63 | 1.6E-09 |
| Josephine Robertson | 41361833 | DNA methylation | O14791 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.050892 | 2E-09 |
| Josephine Robertson | 41361833 | DNA methylation | O14791 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0753297 | 2.4E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0749458 | 2.5E-09 |
| Josephine Robertson | 41361833 | DNA methylation | O14791 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0490461 | 2.8E-09 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg03381168 | chr12:57623211 | SHMT2 | -0.147129 | 3E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P01042 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0499592 | 3.6E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P02760 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.074 | 4.2E-09 |
| Hannon E | 33646943 | DNA methylation | schizophrenia | Whole blood | fixed effects meta-analysis | 3264 | cg08163918 | chr12:57628654 | SHMT2 | -0.56 | 4.5E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P01019 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0733567 | 5.4E-09 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg10952910 | chr12:57623761 | SHMT2 | 0.01 | 6.1E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P02760 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.049 | 7E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P08185 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0708572 | 7.3E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P01042 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0493781 | 7.5E-09 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg01763913 | chr12:57623930 | SHMT2 | 0.00032 | 7.6E-09 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg11350278 | chr12:57623962 | SHMT2 | 0.008 | 8.2E-09 |
| Gadd DA | 35945220 | AKR7A3 protein levels (SeqId = 18173-11) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.55 | 9.5E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.047 | 9.8E-09 |
| Hannon E | 33646943 | DNA methylation | schizophrenia | Whole blood | random effects meta-analysis | 3264 | cg08163918 | chr12:57628654 | SHMT2 | -0.56 | 9.8E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | -0.0472338 | 1E-08 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg12502815 | chr12:57623997 | SHMT2 | 0.18 | 1.2E-08 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg03381168 | chr12:57623211 | SHMT2 | -0.140972 | 1.4E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.047894 | 1.4E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 3 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.064 | 1.5E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02760 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.046 | 1.9E-08 |
| Imgenberg-Kreuz J | 26857698 | DNA methylation | Primary Sjogrens syndrome | Whole blood | Whole blood | 500 | cg02773601 | chr12:57623994 | SHMT2 | NA | 1.9E-08 |
| Gadd DA | 35945220 | ALDOB protein levels (SeqId = 18185-118) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.52 | 2.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.046 | 2.1E-08 |
| Li S | 28811542 | DNA methylation | Age | Whole blood | - | 1366 | cg06868473 | chr12:57622801 | SHMT2 | -0.0109 | 2.4E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P08185 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0462033 | 3E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 2 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.064 | 3.3E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg11851129 | chr12:57624530 | SHMT2 | -0.044 | 3.4E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02787 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.047 | 3.8E-08 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | sensitivity | 18225 | cg08163918 | chr12:57628654 | SHMT2 | 0.29 | 4.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0451487 | 4.5E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0453392 | 4.9E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg11851129 | chr12:57624530 | SHMT2 | -0.00077 | 5.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.046 | 5.4E-08 |
| Hannah M. Smith | 39706196 | DNA methylation | Glucose | Whole blood | sensitivity | 17908 | cg08228578 | chr12:57624193 | SHMT2 | -0.396307 | 5.5E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg08163918 | chr12:57628654 | SHMT2 | -0.006 | 5.8E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.044 | 7.4E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg27039453 | chr12:57623757 | SHMT2 | -0.00028 | 8.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P14151 | whole blood | OSCA model 2 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.05 | 8.6E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02743 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0452143 | 9.8E-08 |
| Gadd DA | 35945220 | FBP1 protein levels (SeqId = 7206-20) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.44 | 1E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg10952910 | chr12:57623761 | SHMT2 | 0.0027 | 1.1E-07 |
| Sikdar S | 31536415 | DNA methylation | Smoking | Whole blood, CD4+ T cells, CD14+ monocytes | random effects meta-analysis | 15907 | cg25110782 | chr12:57624371 | SHMT2 | -0.00331 | 1.1E-07 |
| Sikdar S | 31536415 | DNA methylation | Smoking | Whole blood, CD4+ T cells, CD14+ monocytes | random effects meta-analysis | 15907 | cg11851129 | chr12:57624530 | SHMT2 | -0.00373 | 1.3E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg19621579 | chr12:57623725 | SHMT2 | -0.0001 | 1.4E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg26220528 | chr12:57623348 | SHMT2 | 0.0037 | 1.4E-07 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg01267941 | chr12:57623452 | SHMT2 | 0.004 | 1.4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0445422 | 1.5E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | -0.0432985 | 1.6E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02647 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.043 | 1.9E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg12639933 | chr12:57626296 | SHMT2 | -0.00078 | 2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.043 | 2.1E-07 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg02773601 | chr12:57623994 | SHMT2 | 0.15 | 2.1E-07 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0440952 | 2.3E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 2 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | 0.044 | 2.3E-07 |
| Hannah M. Smith | 39706196 | DNA methylation | Waist-hip ratio | Whole blood | discovery | 17304 | cg12502815 | chr12:57623997 | SHMT2 | -0.164899 | 2.3E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P20742 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.044 | 2.5E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0425492 | 2.5E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.042 | 2.6E-07 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg03381168 | chr12:57623211 | SHMT2 | 0.12 | 2.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0423692 | 2.8E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg19535267 | chr12:57625610 | SHMT2 | 0.0028 | 2.9E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.043 | 3E-07 |
| Gadd DA | 35945220 | POR protein levels (SeqId = 2731-29) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.38 | 3.4E-07 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Prevalent Type 2 Diabetes (Self-report) | Whole blood | Basic model | 18005 | cg08228578 | chr12:57624193 | SHMT2 | -0.12 | 3.4E-07 |
| Gadd DA | 35945220 | ADH4 protein levels (SeqId = 8325-37) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.38 | 3.4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P20742 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 3.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02787 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01008 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 4.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01019 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0431662 | 4.3E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P04196 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0417069 | 4.3E-07 |
| Josephine Robertson | 41361833 | DNA methylation | O14791 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.04297 | 4.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.041 | 5.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P00742 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0414117 | 5.2E-07 |
| Gadd DA | 35945220 | ASL protein levels (SeqId = 11241-8) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.35 | 5.4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0413041 | 5.6E-07 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg03381168 | chr12:57623211 | SHMT2 | -3.4 | 5.6E-07 |
| Dugue P-A | 31789449 | Alcohol consumption | DNA methylation | Whole blood | Lifetime consumption discovery | 5606 | cg11851129 | chr12:57624530 | SHMT2 | NA | 5.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | -0.0426595 | 5.9E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.041 | 6E-07 |
| Gadd DA | 35945220 | AKR1C4 protein levels (SeqId = 18397-5) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.35 | 6.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 6.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02763 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0420192 | 7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.041 | 7.4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P04196 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 7.6E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.041 | 8.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | Q15848 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.042 | 8.3E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.041 | 8.7E-07 |
| Dugue P-A | 31789449 | Alcohol consumption | DNA methylation | Whole blood | Previous decade consumption discovery | 5606 | cg11851129 | chr12:57624530 | SHMT2 | NA | 9E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P01019 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.04 | 9.7E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P00742 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0415291 | 9.9E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg09215553 | chr12:57623421 | SHMT2 | -6e-05 | 1E-06 |
| Gadd DA | 35945220 | SULT2A1 protein levels (SeqId = 9829-91) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.32 | 1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | -0.0402939 | 1E-06 |
| Gadd DA | 35945220 | SORD protein levels (SeqId = 15447-45) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.32 | 1.1E-06 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident Type 2 Diabetes | Whole blood | Basic model | 17749 | cg08228578 | chr12:57624193 | SHMT2 | -0.051 | 1.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.04 | 1.3E-06 |
| Gadd DA | 35945220 | RBP5 protein levels (SeqId = 19241-31) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.31 | 1.3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P10643 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.04 | 1.4E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg12502815 | chr12:57623997 | SHMT2 | -0.153807 | 1.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | Q08380 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0407489 | 1.6E-06 |
| Gadd DA | 35945220 | PCOLCE protein levels (SeqId = 11237-49) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg21549333 | chr12:57623775 | SHMT2 | 0.97 | 1.7E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.06 | 1.7E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.039 | 2.3E-06 |
| Gadd DA | 35945220 | INHBC protein levels (SeqId = 15686-49) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg03381168 | chr12:57623211 | SHMT2 | -0.63 | 2.3E-06 |
| Kazmi N | 31230546 | DNA methylation | Preeclampsia | Cord blood | Meta analysis unadjusted model | 3460 | cg11851129 | chr12:57624530 | SHMT2 | 0.013 | 2.9E-06 |
| Josephine Robertson | 41361833 | DNA methylation | Q08380 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0586076 | 3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0583306 | 3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P00734 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | -0.0385143 | 3.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02743 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0384529 | 3.2E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P14151 | whole blood | OSCA model 3 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.043 | 3.2E-06 |
| Kazmi N | 31230546 | DNA methylation | Preeclampsia | Cord blood | Meta analysis unadjusted model | 3460 | cg25110782 | chr12:57624371 | SHMT2 | 0.011 | 3.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | Q08380 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0382505 | 3.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0390829 | 3.7E-06 |
| Sharp GC | 25855720 | DNA methylation | Maternal underweight | Cord blood | Birth | 601 | cg21549333 | chr12:57623775 | SHMT2 | 0.011 | 3.7E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 3 | 14671 | cg12639933 | chr12:57626296 | SHMT2 | 0.039 | 4E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg01763913 | chr12:57623930 | SHMT2 | 0.13 | 4.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 2 | 14671 | cg12639933 | chr12:57626296 | SHMT2 | 0.038 | 4.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02763 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0572675 | 4.8E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P05546 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0386982 | 4.9E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg04945542 | chr12:57627397 | SHMT2 | -0.18994 | 5E-06 |
| Gadd DA | 35945220 | FAH protein levels (SeqId = 11424-4) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.23 | 5.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.037 | 5.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | 0.037 | 5.7E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg11350278 | chr12:57623962 | SHMT2 | 0.13 | 5.9E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.037 | 6.4E-06 |
| Josephine Robertson | 41361833 | DNA methylation | Q15848 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.037 | 7.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02743 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0553892 | 7.2E-06 |
| Dugue P-A | 31789449 | Alcohol consumption | DNA methylation | Whole blood | Replication | 5704 | cg11851129 | chr12:57624530 | SHMT2 | NA | 7.3E-06 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg12639933 | chr12:57626296 | SHMT2 | -0.0044 | 7.4E-06 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | -0.0368382 | 8.1E-06 |
| Gadd DA | 35945220 | DCXR protein levels (SeqId = 17758-79) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.21 | 8.3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 2 | 14671 | cg03381168 | chr12:57623211 | SHMT2 | -0.036788 | 8.8E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04196 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.038 | 9.3E-06 |
| Gadd DA | 35945220 | ADH1C protein levels (SeqId = 15525-294) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.2 | 9.6E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg08228578 | chr12:57624193 | SHMT2 | 0.22 | 1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01019 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0373594 | 1.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.036 | 1.1E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Glucose | Whole blood | sensitivity | 17908 | cg06868473 | chr12:57622801 | SHMT2 | -0.180821 | 1.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q13790 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.036 | 1.1E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg10952910 | chr12:57623761 | SHMT2 | 0.12 | 1.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 2 | 14671 | cg03381168 | chr12:57623211 | SHMT2 | -0.0364257 | 1.1E-05 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg11350278 | chr12:57623962 | SHMT2 | 0.0018 | 1.2E-05 |
| Gadd DA | 35945220 | AKR1D1 protein levels (SeqId = 18398-1) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.18 | 1.2E-05 |
| Gadd DA | 35945220 | PAPPA protein levels (SeqId = 4148-49) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg04213529 | chr12:57626075 | SHMT2 | -1.11 | 1.2E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg19535267 | chr12:57625610 | SHMT2 | -0.202946 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 1 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | 0.036 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q96PD5 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.055 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02760 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.037 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.037 | 1.5E-05 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg02773601 | chr12:57623994 | SHMT2 | 0.002 | 1.5E-05 |
| Kashima K | 33564054 | DNA methylation | gestational age | Cord blood | None | 110 | cg25110782 | chr12:57624371 | SHMT2 | 0.0017 | 1.5E-05 |
| Gadd DA | 35945220 | FTH1 protein levels (SeqId = 5934-1) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.17 | 1.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P27169 | whole blood | OSCA model 1 | 14671 | cg12502815 | chr12:57623997 | SHMT2 | 0.036 | 1.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P08185 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0356205 | 1.6E-05 |
| Gadd DA | 35945220 | FTL protein levels (SeqId = 15324-58) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.17 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A075B6I0 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.036 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P05546 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0355303 | 1.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0355182 | 1.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q13790 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.037 | 1.7E-05 |
| Gadd DA | 35945220 | KRT1 protein levels (SeqId = 9931-20) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.17 | 1.7E-05 |
| Gadd DA | 35945220 | HRSP12 protein levels (SeqId = 14636-25) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.16 | 1.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 1 | 14671 | cg12639933 | chr12:57626296 | SHMT2 | 0.035 | 1.9E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | sensitivity | 17304 | cg11851129 | chr12:57624530 | SHMT2 | -0.208464 | 1.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0351193 | 2.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02787 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.036 | 2.2E-05 |
| Hannon E | 27572077 | DNA methylation | Schizophrenia | Whole blood | Phase 1 | 675 | cg01763913 | chr12:57623930 | SHMT2 | 0.0047 | 2.3E-05 |
| Gadd DA | 35945220 | PRG3 protein levels (SeqId = 9015-1) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg04213529 | chr12:57626075 | SHMT2 | -1.07 | 2.4E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg11851129 | chr12:57624530 | SHMT2 | -0.195529 | 2.5E-05 |
| Battram T | 23177740 | DNA methylation | Age | Whole blood | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 | 656 | cg06868473 | chr12:57622801 | SHMT2 | -0.0005 | 2.5E-05 |
| Gadd DA | 35945220 | SCUBE1 protein levels (SeqId = 8989-40) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.14 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg23588553 | chr12:57623699 | SHMT2 | 0.035 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.036 | 2.6E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg11851129 | chr12:57624530 | SHMT2 | -0.19386 | 2.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.053 | 2.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | O43866 | whole blood | OSCA model 1 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.035 | 2.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0505873 | 2.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0344489 | 3E-05 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Fully-adjusted model | 14040 | cg08228578 | chr12:57624193 | SHMT2 | -1.7 | 3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg25110782 | chr12:57624371 | SHMT2 | -0.0390736 | 3.1E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | sensitivity | 17304 | cg03381168 | chr12:57623211 | SHMT2 | -0.104981 | 3.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0352785 | 3.2E-05 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident Liver Cirrhosis | Whole blood | Basic model | 18325 | cg08228578 | chr12:57624193 | SHMT2 | -0.014 | 3.2E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg23588553 | chr12:57623699 | SHMT2 | 0.14 | 3.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q96PD5 | whole blood | OSCA model 2 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.035 | 3.4E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | sensitivity | 17304 | cg03381168 | chr12:57623211 | SHMT2 | -0.10508 | 3.5E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | sensitivity | 18225 | cg03381168 | chr12:57623211 | SHMT2 | 0.1 | 3.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 4 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0473034 | 3.6E-05 |
| Dugue P-A | 31789449 | Alcohol consumption | DNA methylation | Whole blood | Previous week consumption discovery | 5606 | cg25110782 | chr12:57624371 | SHMT2 | NA | 3.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | -0.0351471 | 3.7E-05 |
| Gadd DA | 35945220 | GBP1 protein levels (SeqId = 15326-64) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.1 | 3.8E-05 |
| Gadd DA | 35945220 | BDH2 protein levels (SeqId = 17329-2) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.11 | 3.9E-05 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a fixed effect | 2338 | cg01763913 | chr12:57623930 | SHMT2 | 0.0015 | 4.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01019 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0338553 | 4.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 3 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | 0.035 | 4.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.033797 | 4.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0337425 | 4.4E-05 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg11350278 | chr12:57623962 | SHMT2 | 0.0011 | 4.4E-05 |
| Gadd DA | 35945220 | GSTA1 protein levels (SeqId = 17138-8) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.1 | 4.8E-05 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg12502815 | chr12:57623997 | SHMT2 | -0.022 | 4.9E-05 |
| Gadd DA | 35945220 | CTRB1 protein levels (SeqId = 5671-1) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg19535267 | chr12:57625610 | SHMT2 | 1.0 | 5.1E-05 |
| Gadd DA | 35945220 | ADSSL1 protein levels (SeqId = 13998-26) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.097 | 5.1E-05 |
| Gadd DA | 35945220 | GZMA protein levels (SeqId = 3440-7) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.09 | 5.3E-05 |
| Gadd DA | 35945220 | KRT20 protein levels (SeqId = 12975-11) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.09 | 5.3E-05 |
| Gadd DA | 35945220 | TCTN2 protein levels (SeqId = 11433-11) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.09 | 5.3E-05 |
| Gadd DA | 35945220 | ALDH1A1 protein levels (SeqId = 11265-8) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.09 | 5.7E-05 |
| Gadd DA | 35945220 | HMGCS2 protein levels (SeqId = 13704-5) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.09 | 5.9E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg12502815 | chr12:57623997 | SHMT2 | -0.128445 | 6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 2 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.047 | 6E-05 |
| Joehanes R | 27651444 | DNA methylation | Current versus never smoking | Whole blood, CD4+ T cells or monocytes | Current vs never smoking | 9389 | cg25110782 | chr12:57624371 | SHMT2 | -0.0033 | 6.1E-05 |
| Gadd DA | 35945220 | TNFRSF17 protein levels (SeqId = 2665-26) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.08 | 6.1E-05 |
| Gadd DA | 35945220 | IGHM protein levels (SeqId = 3069-52) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg02773601 | chr12:57623994 | SHMT2 | -0.749 | 6.4E-05 |
| Gadd DA | 35945220 | OXT protein levels (SeqId = 8356-88) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.08 | 6.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg11332533 | chr12:57623111 | SHMT2 | 0.033 | 6.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 1 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.033 | 6.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 2 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.046 | 6.7E-05 |
| Gadd DA | 35945220 | HSPA1B protein levels (SeqId = 18901-26) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.08 | 6.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0C4DH34 | whole blood | OSCA model 3 | 14671 | cg04213529 | chr12:57626075 | SHMT2 | -0.0338869 | 6.9E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg08163918 | chr12:57628654 | SHMT2 | 0.19 | 7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 3 | 14671 | cg08163918 | chr12:57628654 | SHMT2 | 0.046 | 7.3E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Waist-hip ratio | Whole blood | discovery | 17304 | cg11851129 | chr12:57624530 | SHMT2 | -0.183043 | 7.5E-05 |
| Gadd DA | 35945220 | OTC protein levels (SeqId = 15431-31) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.07 | 7.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q96PD5 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | 0.034 | 7.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02647 | whole blood | OSCA model 1 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | 0.033 | 7.7E-05 |
| Gross AM | 27105112 | DNA methylation | HIV infection | Neutrophils | Neutrophils | 60 | cg09215553 | chr12:57623421 | SHMT2 | 0.18 | 7.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01714 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0337862 | 7.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01714 | whole blood | OSCA model 1 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | -0.0326072 | 7.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 1 | 14671 | cg11851129 | chr12:57624530 | SHMT2 | 0.033 | 8.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q99459 | whole blood | OSCA model 3 | 14671 | cg11332533 | chr12:57623111 | SHMT2 | -0.0325399 | 8.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | Q99459 | whole blood | OSCA model 2 | 14671 | cg11332533 | chr12:57623111 | SHMT2 | -0.0326986 | 8.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02787 | whole blood | OSCA model 4 | 14671 | cg19621579 | chr12:57623725 | SHMT2 | -0.0334424 | 8.3E-05 |
| Kazmi N | 31230546 | DNA methylation | Hypertensive disorders of pregnancy | Cord blood | Meta analysis unadjusted model | 5242 | cg11851129 | chr12:57624530 | SHMT2 | 0.0048 | 8.4E-05 |
| Gadd DA | 35945220 | PTP4A1 protein levels (SeqId = 17812-2) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.06 | 8.5E-05 |
| Gadd DA | 35945220 | ADH1B protein levels (SeqId = 9834-62) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg08228578 | chr12:57624193 | SHMT2 | -1.06 | 8.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 3 | 14671 | cg08228578 | chr12:57624193 | SHMT2 | -0.0335589 | 8.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00734 | whole blood | OSCA model 1 | 14671 | cg12502815 | chr12:57623997 | SHMT2 | 0.032 | 9.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg12502815 | chr12:57623997 | SHMT2 | -0.0322065 | 9.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 1 | 14671 | cg06868473 | chr12:57622801 | SHMT2 | -0.0321161 | 1E-04 |
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*this tab-deliminated tsv file contains the full set of associations and variables, i.e. those in the downloadable catalog.
