Search results for SNCA
| Author | PMID | Outcome | Exposure | Tissue | Analysis | N | CpG | Location | Gene | Beta | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg01966878 | chr4:90757139 | SNCA | -0.0052 | 0E+00 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg11512365 | chr4:90758494 | SNCA | 0.0028 | 4.9E-242 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg00119181 | chr4:90758537 | SNCA | 0.00022 | 2.9E-163 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg08030922 | chr4:90675036 | SNCA | 0.63 | 1.5E-134 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg15133208 | chr4:90757351 | SNCA | 0.33 | 3.4E-111 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg26578617 | chr4:90757533 | SNCA | 0.062 | 2.5E-68 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg11512365 | chr4:90758494 | SNCA | 0.00028 | 1.9E-65 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg01966878 | chr4:90757139 | SNCA | 0.3 | 2.7E-65 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg14346243 | chr4:90757452 | SNCA | 0.12 | 5.8E-62 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg00193021 | chr4:90758120 | SNCA | 0.00077 | 2.5E-57 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg08708229 | chr4:90758216 | SNCA | 0.00047 | 2E-53 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg12030690 | chr4:90759203 | SNCA | 0.032 | 9.9E-49 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg12030690 | chr4:90759203 | SNCA | 0.00069 | 2.5E-47 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg11661187 | chr4:90756533 | SNCA | 0.092 | 3.1E-47 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg20003494 | chr4:90757398 | SNCA | 0.038 | 4.6E-43 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.108262 | 1.7E-39 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg26578617 | chr4:90757533 | SNCA | 0.00076 | 2.1E-39 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg06632027 | chr4:90757378 | SNCA | 0.075 | 4.6E-38 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg23396644 | chr4:90758777 | SNCA | 0.017 | 2.3E-34 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg08708229 | chr4:90758216 | SNCA | 0.023 | 4.3E-34 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg23396644 | chr4:90758777 | SNCA | 0.00045 | 2.5E-31 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg00119181 | chr4:90758537 | SNCA | 0.00051 | 2.8E-31 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0924078 | 3.4E-29 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg00193021 | chr4:90758120 | SNCA | 0.028 | 3.2E-28 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg01035160 | chr4:90758529 | SNCA | 0.00027 | 2.8E-27 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg00119181 | chr4:90758537 | SNCA | 0.014 | 3.7E-27 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg10208370 | chr4:90758469 | SNCA | 0.00023 | 1.3E-26 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.087332 | 3.1E-26 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.086105 | 1.5E-25 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0836927 | 3.2E-24 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg08708229 | chr4:90758216 | SNCA | NA | 2.2E-23 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.079307 | 6.6E-22 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg20003494 | chr4:90757398 | SNCA | 0.0011 | 9.6E-22 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg20776829 | chr4:90758797 | SNCA | 0.0093 | 1.1E-20 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg01035160 | chr4:90758529 | SNCA | 0.017 | 1.8E-20 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg06176111 | chr4:90674837 | SNCA | -0.391476 | 3E-20 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0752814 | 6.8E-20 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg25813193 | chr4:90690588 | SNCA | 0.047 | 2.3E-19 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg00119181 | chr4:90758537 | SNCA | NA | 2.4E-19 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg11512365 | chr4:90758494 | SNCA | 0.011 | 2.7E-18 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.0707592 | 9.4E-18 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg20776829 | chr4:90758797 | SNCA | NA | 1.3E-17 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0689571 | 6.2E-17 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.068 | 1.2E-16 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg10208370 | chr4:90758469 | SNCA | 0.011 | 1.6E-16 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg12030690 | chr4:90759203 | SNCA | 0.00052 | 2.2E-16 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg14346243 | chr4:90757452 | SNCA | 0.0012 | 3.6E-16 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 6y with age as a random effect | 2338 | cg11512365 | chr4:90758494 | SNCA | 0.00076 | 1E-15 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg05241924 | chr4:90759115 | SNCA | 0.033 | 1.5E-15 |
| Yao C | 33752734 | DNA methylation | Gene expression of Affymetrix ID: 2777714 (gene symbol: SNCA) | Whole blood | Meta-analysis | 4170 | cg01966878 | chr4:90757139 | SNCA | NA | 1.5E-15 |
| Yao C | 33752734 | DNA methylation | Gene expression of Affymetrix ID: 2777714 (gene symbol: SNCA) | Whole blood | Meta-analysis | 4170 | cg06632027 | chr4:90757378 | SNCA | NA | 2.1E-15 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.07 | 3.9E-15 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.064 | 1.1E-14 |
| Wozniak MB | 23526956 | DNA methylation | Clear cell renal carcinoma | Clear cell renal carcinoma tumour cells and adjacent healthy cells | - | 129 | cg02192967 | chr4:90758406 | SNCA | NA | 2.1E-14 |
| Gross AM | 27105112 | DNA methylation | HIV infection | Whole blood | Discovery | 181 | cg02192967 | chr4:90758406 | SNCA | 2.4 | 4.4E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0618893 | 6.2E-14 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg01035160 | chr4:90758529 | SNCA | 0.00021 | 6.7E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.062 | 8.1E-14 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.0615595 | 8.5E-14 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg10731794 | chr4:90759057 | SNCA | 0.027 | 1.2E-13 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0658997 | 2.8E-13 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0599615 | 3.6E-13 |
| Imgenberg-Kreuz J | 26857698 | DNA methylation | Primary Sjogrens syndrome | Whole blood | Whole blood | 500 | cg25813193 | chr4:90690588 | SNCA | NA | 4E-13 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0590273 | 8.4E-13 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg06632027 | chr4:90757378 | SNCA | 0.00054 | 1.1E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.058 | 1.8E-12 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg00193021 | chr4:90758120 | SNCA | 0.0018 | 2.1E-12 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg00119181 | chr4:90758537 | SNCA | 0.029 | 2.2E-12 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.057 | 3.2E-12 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.061 | 4.1E-12 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg06176111 | chr4:90674837 | SNCA | -0.295207 | 4.2E-12 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg00193021 | chr4:90758120 | SNCA | 0.00044 | 4.4E-12 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg08030922 | chr4:90675036 | SNCA | -0.0017 | 4.8E-12 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.056327 | 8.6E-12 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.055323 | 2E-11 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg14346243 | chr4:90757452 | SNCA | 0.024 | 2.8E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | 0.055 | 3.1E-11 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg02192967 | chr4:90758406 | SNCA | 0.0076 | 3.7E-11 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0536138 | 8.1E-11 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg15133208 | chr4:90757351 | SNCA | -0.0013 | 9.7E-11 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg01966878 | chr4:90757139 | SNCA | 0.0028 | 1.6E-10 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.058 | 1.6E-10 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0573309 | 2.2E-10 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg06176111 | chr4:90674837 | SNCA | -1.9 | 2.6E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.052 | 2.7E-10 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg15452573 | chr4:90758843 | SNCA | 0.00029 | 2.8E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0517329 | 3.6E-10 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | 0.052 | 3.7E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0513652 | 4.8E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | 0.051 | 6.1E-10 |
| Battram T | 30602389 | DNA methylation | Tissue | Buccal cells and peripheral blood mononuclear cells | EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells | 215 | cg15452573 | chr4:90758843 | SNCA | 0.0095 | 8.5E-10 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg26578617 | chr4:90757533 | SNCA | 0.00044 | 9.1E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | 0.05 | 9.6E-10 |
| Nones K | 24500968 | DNA methylation | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata | - | 196 | cg08708229 | chr4:90758216 | SNCA | NA | 9.7E-10 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0498589 | 1.5E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0496518 | 1.8E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 2 | 14671 | cg00119181 | chr4:90758537 | SNCA | -0.0532503 | 1.8E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | 0.05 | 1.9E-09 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg14346243 | chr4:90757452 | SNCA | 0.12 | 2E-09 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg26578617 | chr4:90757533 | SNCA | 0.16 | 2.4E-09 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg06632027 | chr4:90757378 | SNCA | 0.00037 | 3.8E-09 |
| Spiers H | 25650246 | DNA methylation | Gestational age | Fetal brain | - | 179 | cg11661187 | chr4:90756533 | SNCA | 0.074 | 4.7E-09 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg20003494 | chr4:90757398 | SNCA | 0.00072 | 5.7E-09 |
| Yao C | 33752734 | DNA methylation | Gene expression of Affymetrix ID: 2777714 (gene symbol: SNCA) | Whole blood | Meta-analysis | 4170 | cg26578617 | chr4:90757533 | SNCA | NA | 6.8E-09 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg01966878 | chr4:90757139 | SNCA | -0.0472758 | 1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.047 | 1.1E-08 |
| Nones K | 24500968 | DNA methylation | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata | - | 196 | cg00119181 | chr4:90758537 | SNCA | NA | 1.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.047 | 1.2E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.051 | 1.2E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 3 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.05 | 1.4E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg00193021 | chr4:90758120 | SNCA | 0.025 | 1.4E-08 |
| Nones K | 24500968 | DNA methylation | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata | - | 196 | cg20776829 | chr4:90758797 | SNCA | NA | 1.5E-08 |
| Hannah M. Smith | 39706196 | DNA methylation | HDL cholesterol | Whole blood | discovery | 18225 | cg06176111 | chr4:90674837 | SNCA | 0.24 | 1.6E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg02192967 | chr4:90758406 | SNCA | 0.027 | 1.9E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P00734 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.046 | 2E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.046 | 2.4E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg06176111 | chr4:90674837 | SNCA | -0.041 | 2.5E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 3 | 14671 | cg00119181 | chr4:90758537 | SNCA | -0.0494388 | 2.5E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg26578617 | chr4:90757533 | SNCA | 0.0021 | 2.7E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident Type 2 Diabetes | Whole blood | Basic model | 17749 | cg06176111 | chr4:90674837 | SNCA | -0.048 | 3.1E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.045645 | 3.2E-08 |
| Gross AM | 27105112 | DNA methylation | HIV infection | Whole blood | Discovery | 181 | cg23396644 | chr4:90758777 | SNCA | 1.3 | 3.4E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg12030690 | chr4:90759203 | SNCA | 0.0018 | 3.7E-08 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg10208370 | chr4:90758469 | SNCA | 0.024 | 4.3E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0450486 | 4.8E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0448923 | 5.3E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P00450 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0446438 | 6.3E-08 |
| Liu Y | 23334450 | DNA methylation | Rheumatoid arthritis | Whole blood | - | 691 | cg06848047 | chr4:90757629 | SNCA | 0.011 | 6.7E-08 |
| Nones K | 24500968 | DNA methylation | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata | - | 196 | cg01035160 | chr4:90758529 | SNCA | NA | 7.7E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0442917 | 8E-08 |
| Nones K | 24500968 | DNA methylation | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata | - | 196 | cg02192967 | chr4:90758406 | SNCA | NA | 8.3E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.048 | 8.6E-08 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a fixed effect | 2338 | cg23396644 | chr4:90758777 | SNCA | 0.00024 | 8.8E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | 0.044 | 9.5E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0440162 | 9.6E-08 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0439512 | 1E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0433324 | 1.5E-07 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 4 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.055 | 1.6E-07 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | 0.042 | 3.3E-07 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg14346243 | chr4:90757452 | SNCA | 1.6 | 3.4E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P02763 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.0419212 | 3.8E-07 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | 0.042 | 4.1E-07 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg08708229 | chr4:90758216 | SNCA | 0.021 | 4.1E-07 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg26578617 | chr4:90757533 | SNCA | 0.024 | 4.4E-07 |
| Hannah M. Smith | 39706196 | DNA methylation | Waist-hip ratio | Whole blood | discovery | 17304 | cg06176111 | chr4:90674837 | SNCA | -0.21435 | 4.5E-07 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg08030922 | chr4:90675036 | SNCA | 0.0016 | 4.6E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0414296 | 5.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg01966878 | chr4:90757139 | SNCA | -0.0414211 | 5.2E-07 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg20003494 | chr4:90757398 | SNCA | 0.091 | 6.1E-07 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg00193021 | chr4:90758120 | SNCA | 5.7 | 6.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.043 | 6.6E-07 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg11512365 | chr4:90758494 | SNCA | 0.024 | 7.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.044 | 8.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P04003 | whole blood | OSCA model 2 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0450395 | 8.2E-07 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.040406 | 9.8E-07 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.044 | 1E-06 |
| Hannah M. Smith | 39706196 | DNA methylation | BMI | Whole blood | discovery | 17304 | cg06632027 | chr4:90757378 | SNCA | 0.081 | 1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg01966878 | chr4:90757139 | SNCA | -0.0402859 | 1.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0401911 | 1.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04003 | whole blood | OSCA model 1 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0401012 | 1.2E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P00740 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0436072 | 1.3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg01035160 | chr4:90758529 | SNCA | 0.04 | 1.4E-06 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.042 | 1.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 1 | 14671 | cg00119181 | chr4:90758537 | SNCA | -0.039451 | 1.8E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 2 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.042 | 1.8E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 3 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.041 | 1.9E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04003 | whole blood | OSCA model 3 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0431047 | 2.2E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 1 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.039 | 2.5E-06 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg23396644 | chr4:90758777 | SNCA | 0.0011 | 2.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg23691600 | chr4:90721491 | SNCA | 0.039 | 3.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 2 | 14671 | cg08708229 | chr4:90758216 | SNCA | -0.0413023 | 3.1E-06 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg08030922 | chr4:90675036 | SNCA | 0.0053 | 3.2E-06 |
| Darina Czamara | 38600394 | DNA methylation | sex | placenta | meta-analysis of robust linear regression results per cohort | 746 | cg00119181 | chr4:90758537 | SNCA | 0.6 | 3.2E-06 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 1 with age as a random effect | 2338 | cg02192967 | chr4:90758406 | SNCA | 8e-05 | 3.5E-06 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 9y with age as a random effect | 2338 | cg15452573 | chr4:90758843 | SNCA | 0.0009 | 3.5E-06 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg20776829 | chr4:90758797 | SNCA | 0.016 | 4E-06 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg14346243 | chr4:90757452 | SNCA | 0.016 | 4.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 1 | 14671 | cg08708229 | chr4:90758216 | SNCA | -0.0378987 | 4.4E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg11512365 | chr4:90758494 | SNCA | 0.038 | 4.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 2 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.04 | 4.7E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04114 | whole blood | OSCA model 1 | 14671 | cg01966878 | chr4:90757139 | SNCA | 0.038 | 4.7E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 1 | 14671 | cg02192967 | chr4:90758406 | SNCA | 0.037 | 5.8E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0373138 | 6.2E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.0372834 | 6.3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 3 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.04 | 6.4E-06 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident COPD | Whole blood | Basic model | 17902 | cg01035160 | chr4:90758529 | SNCA | 0.022 | 6.5E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P20742 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.041 | 6.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0370622 | 7.1E-06 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg26578617 | chr4:90757533 | SNCA | 2.8 | 7.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0368414 | 8.1E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0368056 | 8.2E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 1 | 14671 | cg01681236 | chr4:90647041 | SNCA | 0.037 | 8.3E-06 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | 0.037 | 8.9E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P06310 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | 0.037 | 9.6E-06 |
| Josephine Robertson | 41361833 | DNA methylation | P01031 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.0364272 | 1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0364067 | 1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.036 | 1.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.036 | 1.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0360297 | 1.3E-05 |
| Darina Czamara | 38600394 | DNA methylation | sex | placenta | meta-analysis of robust linear regression results per cohort | 746 | cg08708229 | chr4:90758216 | SNCA | 0.35 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.039 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.036 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P05546 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0392159 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 1 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.036 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02775 | whole blood | OSCA model 1 | 14671 | cg02163025 | chr4:90722285 | SNCA | -0.0359399 | 1.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 2 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.038 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02763 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0358948 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | 0.036 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02749 | whole blood | OSCA model 3 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0401139 | 1.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 3 | 14671 | cg08708229 | chr4:90758216 | SNCA | -0.038341 | 1.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04003 | whole blood | OSCA model 1 | 14671 | cg02163025 | chr4:90722285 | SNCA | 0.036 | 1.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg02192967 | chr4:90758406 | SNCA | 0.037 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 4 | 14671 | cg11661187 | chr4:90756533 | SNCA | 0.037 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P00747 | whole blood | OSCA model 1 | 14671 | cg11661187 | chr4:90756533 | SNCA | 0.036 | 1.6E-05 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg01035160 | chr4:90758529 | SNCA | 2.6 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0356044 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 2 | 14671 | cg08708229 | chr4:90758216 | SNCA | -0.0381591 | 1.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0355553 | 1.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.0355427 | 1.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 2 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0393175 | 1.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P18428 | whole blood | OSCA model 1 | 14671 | cg01681236 | chr4:90647041 | SNCA | 0.035 | 1.8E-05 |
| Gross AM | 27105112 | DNA methylation | HIV infection | Neutrophils | Neutrophils | 60 | cg23396644 | chr4:90758777 | SNCA | 0.18 | 1.8E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg26578617 | chr4:90757533 | SNCA | 0.12 | 1.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | O75882 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | 0.035 | 1.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 3 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.042 | 2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.037 | 2.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P51884 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.038 | 2.4E-05 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg15452573 | chr4:90758843 | SNCA | 3.7 | 2.4E-05 |
| Gross AM | 27105112 | DNA methylation | HIV infection | Whole blood | Discovery | 181 | cg08708229 | chr4:90758216 | SNCA | 0.94 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06727 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.038 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.034809 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 1 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.035 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 1 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0347606 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01834 | whole blood | OSCA model 1 | 14671 | cg00119181 | chr4:90758537 | SNCA | 0.035 | 2.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | 0.035 | 2.7E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Total cholesterol | Whole blood | discovery | 18270 | cg23396644 | chr4:90758777 | SNCA | -0.13861 | 2.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.0345033 | 2.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | -0.034479 | 3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0344336 | 3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02671 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | -0.0344165 | 3.1E-05 |
| Robert F. Hillary | doi.org/10.1101/2023.11.02.23298000 | C-reactive protein (CRP) levels | DNA methylation | Whole blood | Basic model | 17936 | cg12030690 | chr4:90759203 | SNCA | 2.7 | 3.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 2 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.041 | 3.2E-05 |
| Fragoso-Bargas Nicolas | 39844050 | DNA methylation | Sedentary behaviour | Whole blood | discovery (stp adjusted) | 353 | cg12030690 | chr4:90759203 | SNCA | -0.053481886 | 3.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | B1AHL2 | whole blood | OSCA model 2 | 14671 | cg02163025 | chr4:90722285 | SNCA | 0.035 | 3.4E-05 |
| Singmann P | 26500701 | DNA methylation | Sex | Whole blood | KORA F4 | 1799 | cg12030690 | chr4:90759203 | SNCA | NA | 3.5E-05 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg11661187 | chr4:90756533 | SNCA | 1.9 | 3.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | -0.034056 | 3.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg01966878 | chr4:90757139 | SNCA | 0.034 | 3.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | 0.034 | 3.7E-05 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg20776829 | chr4:90758797 | SNCA | 1.8 | 3.8E-05 |
| Hannah M. Smith | 39706196 | DNA methylation | Body fat | Whole blood | discovery | 17304 | cg20003494 | chr4:90757398 | SNCA | 0.075 | 3.9E-05 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg11512365 | chr4:90758494 | SNCA | 1.8 | 4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02748 | whole blood | OSCA model 3 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.036 | 4.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P36955 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.036 | 4.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02749 | whole blood | OSCA model 4 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0400525 | 4.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P29622 | whole blood | OSCA model 1 | 14671 | cg20003494 | chr4:90757398 | SNCA | 0.034 | 4.4E-05 |
| Gadd DA | 35945220 | IL2RB protein levels (SeqId = 9343-16) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg11512365 | chr4:90758494 | SNCA | -0.61 | 4.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P78563 | whole blood | OSCA model 2 | 14671 | cg10208370 | chr4:90758469 | SNCA | 0.035 | 4.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01008 | whole blood | OSCA model 1 | 14671 | cg02163025 | chr4:90722285 | SNCA | 0.034 | 4.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0335868 | 4.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | 0.034 | 4.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P25311 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | -0.033499 | 4.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04217 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0334453 | 5.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 2 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0369151 | 5.5E-05 |
| Darina Czamara | 38600394 | DNA methylation | sex | placenta | meta-analysis of robust linear regression results per cohort | 746 | cg00193021 | chr4:90758120 | SNCA | 0.33 | 5.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 2 | 14671 | cg20003494 | chr4:90757398 | SNCA | 0.036 | 5.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02750 | whole blood | OSCA model 2 | 14671 | cg00193021 | chr4:90758120 | SNCA | 0.036 | 5.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02749 | whole blood | OSCA model 2 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0370352 | 5.9E-05 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 1 | 14671 | cg06632027 | chr4:90757378 | SNCA | 0.033 | 6.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P14151 | whole blood | OSCA model 2 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0373677 | 6.2E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P06396 | whole blood | OSCA model 3 | 14671 | cg06176111 | chr4:90674837 | SNCA | 0.036 | 6.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01023 | whole blood | OSCA model 4 | 14671 | cg06848047 | chr4:90757629 | SNCA | 0.035 | 6.6E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02790 | whole blood | OSCA model 1 | 14671 | cg12030690 | chr4:90759203 | SNCA | -0.0329104 | 6.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04004 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.035867 | 6.7E-05 |
| Gadd DA | 35945220 | GZMA protein levels (SeqId = 3440-7) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg06176111 | chr4:90674837 | SNCA | -0.86 | 6.8E-05 |
| Robert F Hillary | 10.1101/2023.01.10.23284387 | DNA methylation | Incident Lung Cancer | Whole blood | Basic model | 18364 | cg00193021 | chr4:90758120 | SNCA | 0.0095 | 7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P04196 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.033 | 7.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01024 | whole blood | OSCA model 3 | 14671 | cg08708229 | chr4:90758216 | SNCA | -0.0319483 | 7.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01742 | whole blood | OSCA model 2 | 14671 | cg06176111 | chr4:90674837 | SNCA | -0.0355509 | 7.4E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 3 | 14671 | cg08708229 | chr4:90758216 | SNCA | 0.035 | 7.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 3 | 14671 | cg00193021 | chr4:90758120 | SNCA | -0.0357759 | 8E-05 |
| Mulder RH | 33450751 | DNA methylation | sex | Whole blood | Discovery | 2338 | cg01681236 | chr4:90647041 | SNCA | 0.0088 | 8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P43251 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.033 | 8.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | A0A0G2JMB2 | whole blood | OSCA model 2 | 14671 | cg11512365 | chr4:90758494 | SNCA | 0.034 | 8.1E-05 |
| Josephine Robertson | 41361833 | DNA methylation | O75636 | whole blood | OSCA model 1 | 14671 | cg14346243 | chr4:90757452 | SNCA | 0.032 | 8.3E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P01709 | whole blood | OSCA model 2 | 14671 | cg15452573 | chr4:90758843 | SNCA | -0.0334083 | 8.5E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02751 | whole blood | OSCA model 3 | 14671 | cg11512365 | chr4:90758494 | SNCA | -0.0335852 | 8.6E-05 |
| Gadd DA | 35945220 | AMY2A protein levels (SeqId = 18917-53) | DNA methylation | Whole blood | SomaScan protein measurement | 774 | cg12030690 | chr4:90759203 | SNCA | -0.69 | 8.6E-05 |
| Inkster A | 34044884 | DNA methylation | Sex | Placenta | Discovery | 585 | cg23396644 | chr4:90758777 | SNCA | 1.1 | 8.7E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P02749 | whole blood | OSCA model 1 | 14671 | cg26578617 | chr4:90757533 | SNCA | -0.0323731 | 8.8E-05 |
| Josephine Robertson | 41361833 | DNA methylation | P08185 | whole blood | OSCA model 1 | 14671 | cg15133208 | chr4:90757351 | SNCA | 0.032 | 8.8E-05 |
| Darina Czamara | 38600394 | DNA methylation | sex | placenta | meta-analysis of robust linear regression results per cohort | 746 | cg03281257 | chr4:90750836 | SNCA | -0.1756789 | 9.4E-05 |
| Mulder RH | 33450751 | DNA methylation | age | Whole blood | Model 2 at 6y with age as a fixed effect | 2338 | cg15133208 | chr4:90757351 | SNCA | 0.0053 | 9.8E-05 |
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*this tab-deliminated tsv file contains the full set of associations and variables, i.e. those in the downloadable catalog.
