author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-1.44	0.0658	3.05e-106	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03636183	chr19:17000585	19	17000585	F2RL3	North shore	-0.66	0.0344	5.37e-82	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21566642	chr2:233284661	2	233284661	-	Island	-0.92	0.0488	2.1400000000000003e-79	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.61	0.0336	7.44e-74	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05951221	chr2:233284402	2	233284402	-	Island	-0.63	0.0359	7.52e-69	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.76	0.0463	2.0000000000000002e-60	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26703534	chr5:377358	5	377358	AHRR	South shelf	-0.32	0.0198	9.82e-59	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.46	0.029	8.510000000000001e-57	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14817490	chr5:392920	5	392920	AHRR	Open sea	-0.42	0.033	4.2200000000000006e-37	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25648203	chr5:395444	5	395444	AHRR	Open sea	-0.35	0.0275	5.14e-37	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24859433	chr6:30720203	6	30720203	-	Open sea	-0.33	0.0267	4.43e-35	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03329539	chr2:233283329	2	233283329	-	North shore	-0.35	0.0284	6.51e-35	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14753356	chr6:30720108	6	30720108	-	Open sea	-0.27	0.0222	3.5499999999999998e-34	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21611682	chr11:68138269	11	68138269	LRP5	Open sea	-0.2	0.0167	5.51e-33	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09935388	chr1:92947588	1	92947588	GFI1	Island	-0.67	0.0562	9.56e-33	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25189904	chr1:68299493	1	68299493	GNG12	South shore	-0.56	0.0471	1.25e-32	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15342087	chr6:30720209	6	30720209	-	Open sea	-0.27	0.0228	2.09e-32	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11660018	chr11:86510915	11	86510915	PRSS23	North shore	-0.26	0.0229	6.89e-30	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05284742	chr14:93552128	14	93552128	ITPK1	Open sea	-0.21	0.0185	1.0300000000000001e-29	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19572487	chr17:38476024	17	38476024	RARA	South shore	-0.32	0.0286	4.8200000000000004e-29	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06644428	chr2:233284112	2	233284112	-	Island	-0.71	0.065	8.48e-28	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02451831	chr7:26578098	7	26578098	KIAA0087	Open sea	-0.22	0.0202	1.3700000000000001e-27	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19859270	chr3:98251294	3	98251294	GPR15	Open sea	-0.34	0.0317	8.57e-27	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01692968	chr9:108005349	9	108005349	-	North shore	-0.29	0.0272	1.3600000000000002e-26	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg27537125	chr1:25349681	1	25349681	-	Open sea	-0.21	0.0198	2.5500000000000002e-26	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01901332	chr11:75031054	11	75031054	ARRB1	Open sea	-0.26	0.0245	2.97e-26	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg27241845	chr2:233250370	2	233250370	-	North shore	-0.29	0.0275	5.77e-26	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04885881	chr1:11123118	1	11123118	-	South shelf	-0.29	0.0277	1.41e-25	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08709672	chr1:206224334	1	206224334	AVPR1B	South shore	-0.19	0.0184	4.75e-25	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21322436	chr7:145812842	7	145812842	CNTNAP2	North shore	-0.24	0.0235	1.49e-24	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03450842	chr10:80834947	10	80834947	ZMIZ1	Open sea	-0.17	0.017	1.9599999999999997e-23	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14580211	chr5:150161299	5	150161299	C5orf62	South shelf	-0.27	0.0271	2.3299999999999996e-23	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07826859	chr7:45020086	7	45020086	MYO1G	Open sea	-0.14	0.0141	2.69e-23	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06235438	chr16:30485966	16	30485966	ITGAL	South shore	-0.22	0.0226	1.78e-22	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20295214	chr1:206226794	1	206226794	AVPR1B	South shelf	-0.28	0.0288	2.44e-22	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23771366	chr11:86510998	11	86510998	PRSS23	North shore	-0.23	0.024	1.0900000000000001e-21	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03991871	chr5:368447	5	368447	AHRR	North shore	-0.48	0.0504	1.6300000000000001e-21	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00073090	chr19:1265879	19	1265879	-	Island	-0.17	0.0179	2.08e-21	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12513616	chr5:177370977	5	177370977	-	Island	-0.2	0.0214	8.9e-21	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04551776	chr5:393366	5	393366	AHRR	Open sea	-0.21	0.0229	4.3e-20	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25305703	chr8:128378218	8	128378218	-	Open sea	-0.33	0.036	4.52e-20	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07251887	chr17:73641809	17	73641809	LOC100130933;RECQL5	Open sea	-0.17	0.0185	4.93e-20	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24090911	chr5:400732	5	400732	AHRR	Open sea	-0.28	0.031	1.7e-19	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03707168	chr19:49379127	19	49379127	PPP1R15A	South shelf	-0.25	0.0278	2.58e-19	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23916896	chr5:368804	5	368804	AHRR	North shore	-0.51	0.0568	2.93e-19	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10750182	chr10:73497514	10	73497514	C10orf105;CDH23	Open sea	-0.12	0.0134	3.54e-19	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23161492	chr15:90357202	15	90357202	ANPEP	North shore	-0.3	0.0339	8.68e-19	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07986378	chr12:11898284	12	11898284	ETV6	Open sea	-0.31	0.0355	2.57e-18	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25949550	chr7:145814306	7	145814306	CNTNAP2	South shore	-0.24	0.0276	3.09e-18	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22132788	chr7:45002486	7	45002486	MYO1G	Island	1.07	0.1231	3.57e-18	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26963277	chr11:2722407	11	2722407	KCNQ1OT1;KCNQ1	South shore	-0.39	0.0455	9.93e-18	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12876356	chr1:92946825	1	92946825	GFI1	Island	-0.41	0.0481	1.63e-17	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26764244	chr1:68299511	1	68299511	GNG12	South shore	-0.35	0.0413	2.28e-17	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09099830	chr16:30485485	16	30485485	ITGAL	Island	-0.22	0.0263	5.98e-17	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25292882	chr15:39431467	15	39431467	-	Open sea	-0.25	0.03	7.86e-17	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17287155	chr5:393347	5	393347	AHRR	Open sea	-0.32	0.0385	9.67e-17	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00501876	chr3:39193251	3	39193251	CSRNP1	North shore	-0.14	0.0169	1.03e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11207515	chr7:146904205	7	146904205	CNTNAP2	Open sea	0.29	0.0354	2.74e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01899089	chr5:369969	5	369969	AHRR	North shore	-0.16	0.0196	3.58e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26361535	chr8:144576604	8	144576604	ZC3H3	Open sea	-0.27	0.0332	4.62e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05460226	chr17:8804279	17	8804279	PIK3R5	Open sea	-0.2	0.0247	5.37e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13193840	chr2:233285289	2	233285289	-	Island	-0.29	0.0359	6.96e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13500388	chr16:67062135	16	67062135	CBFB	North shore	-0.15	0.0186	7.94e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16047567	chr1:12664243	1	12664243	DHRS3	Open sea	-0.22	0.0274	8.92e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00295485	chr2:106755721	2	106755721	UXS1	Open sea	-0.21	0.0262	9.76e-16	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01127300	chr22:38614796	22	38614796	-	South shelf	-0.24	0.03	0.00000000000000128	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12803068	chr7:45002919	7	45002919	MYO1G	South shore	0.59	0.0746	0.00000000000000253	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00310412	chr15:74724918	15	74724918	SEMA7A	North shore	-0.14	0.0177	0.00000000000000297	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02583484	chr12:54677008	12	54677008	HNRNPA1;HNRPA1L-2	South shelf	-0.16	0.0203	0.00000000000000313	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07123182	chr11:2722391	11	2722391	KCNQ1OT1;KCNQ1	South shore	-0.53	0.0677	0.00000000000000485	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23110422	chr21:40182073	21	40182073	ETS2	South shelf	-0.26	0.0333	0.00000000000000545	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02657160	chr3:98311063	3	98311063	CPOX	North shore	-0.21	0.0269	0.00000000000000555	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15159987	chr19:17003890	19	17003890	CPAMD8	North shelf	-0.15	0.0193	0.00000000000000838	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25323554	chr17:27135257	17	27135257	C17orf63	North shelf	-0.15	0.0193	0.00000000000000896	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10420527	chr11:68138505	11	68138505	LRP5	Open sea	-0.1	0.0129	0.0000000000000105	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23576855	chr5:373299	5	373299	AHRR	North shore	-0.9	0.1164	0.0000000000000108	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26905258	chr13:77898407	13	77898407	MYCBP2	North shelf	-0.11	0.0143	0.0000000000000146	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03604011	chr5:400201	5	400201	AHRR	Open sea	0.4	0.0521	0.0000000000000165	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06972908	chr16:30488321	16	30488321	ITGAL	South shelf	-0.17	0.0222	0.0000000000000167	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01693305	chr1:19813311	1	19813311	CAPZB	South shore	-0.17	0.0223	0.0000000000000231	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09662411	chr1:92946132	1	92946132	GFI1	Island	-0.24	0.0315	0.0000000000000252	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11902777	chr5:368843	5	368843	AHRR	North shore	-0.32	0.0423	0.0000000000000404	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11231349	chr1:162050656	1	162050656	NOS1AP	Open sea	-0.32	0.0425	0.0000000000000497	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05221370	chr7:110738836	7	110738836	LRRN3;IMMP2L	Open sea	-0.34	0.0452	0.0000000000000531	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14624207	chr11:68142198	11	68142198	LRP5	Open sea	-0.13	0.0173	0.0000000000000654	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15474579	chr6:36645812	6	36645812	CDKN1A	North shore	-0.16	0.0214	0.0000000000000778	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16201146	chr20:19191526	20	19191526	-	North shore	-0.15	0.0203	0.000000000000147	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11619216	chr17:73642080	17	73642080	LOC100130933;RECQL5	Open sea	-0.12	0.0162	0.000000000000148	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16556677	chr11:2722401	11	2722401	KCNQ1OT1;KCNQ1	South shore	-0.19	0.0258	0.000000000000171	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16391678	chr16:30485597	16	30485597	ITGAL	Island	-0.16	0.0218	0.000000000000207	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07069636	chr16:30671749	16	30671749	-	South shore	-0.12	0.0163	0.000000000000208	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26856289	chr1:24307516	1	24307516	SFRS13A	South shore	-0.15	0.0204	0.000000000000218	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19254163	chr11:60623782	11	60623782	GPR44	South shelf	-0.14	0.0191	0.000000000000231	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23667432	chr2:233244439	2	233244439	ALPP	Island	-0.13	0.0178	0.000000000000282	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23233742	chr5:139077894	5	139077894	-	South shore	-0.14	0.0192	0.000000000000302	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16611234	chr11:58870075	11	58870075	-	Island	-0.24	0.033	0.00000000000036	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12806681	chr5:368394	5	368394	AHRR	North shore	-0.37	0.0511	0.000000000000436	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19589396	chr8:103937374	8	103937374	-	Open sea	-0.19	0.0263	0.000000000000508	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18316974	chr1:92947035	1	92947035	GFI1	Island	-0.83	0.1154	0.000000000000627	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07339236	chr20:50312490	20	50312490	ATP9A	Open sea	-0.3	0.0418	0.000000000000676	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13184736	chr1:68299409	1	68299409	GNG12	South shore	-0.39	0.0545	0.000000000000814	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21446172	chr1:223745234	1	223745234	CAPN8	South shore	-0.16	0.0224	0.000000000000878	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04716530	chr16:30485684	16	30485684	ITGAL	Island	-0.16	0.0225	0.00000000000108	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20778199	chr6:148020881	6	148020881	-	Open sea	-0.27	0.0379	0.00000000000111	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16219322	chr5:399012	5	399012	AHRR	Open sea	-0.18	0.0253	0.00000000000117	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16519923	chr16:30485810	16	30485810	ITGAL	South shore	-0.14	0.0197	0.00000000000124	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20059012	chr12:53613154	12	53613154	RARG	North shore	-0.99	0.1396	0.00000000000132	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13038618	chr14:77467391	14	77467391	-	Open sea	-0.15	0.0213	0.00000000000169	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11071448	chr1:202584465	1	202584465	SYT2	Open sea	-0.15	0.0213	0.00000000000186	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07202214	chr11:76381081	11	76381081	LRRC32	North shore	-0.17	0.0242	0.00000000000207	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26271591	chr2:178125956	2	178125956	NFE2L2	North shelf	-0.24	0.0343	0.00000000000281	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13976502	chr14:74227875	14	74227875	C14orf43	South shore	-0.13	0.0187	0.0000000000039	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01554474	chr1:155107599	1	155107599	RAG1AP1	North shore	-0.18	0.0259	0.000000000004	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12303084	chr20:45985741	20	45985741	ZMYND8	Open sea	-0.17	0.0245	0.00000000000409	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01731783	chr14:74211788	14	74211788	C14orf43	Open sea	-0.1	0.0144	0.00000000000427	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20124610	chr13:111357885	13	111357885	CARS2	North shore	-0.13	0.0188	0.00000000000435	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10062919	chr17:38503802	17	38503802	RARA	South shore	-0.08	0.0116	0.00000000000467	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22851561	chr14:74214183	14	74214183	C14orf43	Open sea	-0.16	0.0232	0.00000000000581	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11554391	chr5:321320	5	321320	AHRR	Island	-0.2	0.0291	0.00000000000591	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18642234	chr3:49394622	3	49394622	GPX1	North shore	-0.11	0.016	0.00000000000682	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07381806	chr19:2094327	19	2094327	MOBKL2A	North shore	-0.3	0.0439	0.00000000000824	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14316231	chr8:41895100	8	41895100	MYST3	Open sea	-0.13	0.019	0.00000000000847	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22950598	chr12:56139862	12	56139862	GDF11	South shelf	-0.15	0.022	0.00000000000896	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23973524	chr19:18873222	19	18873222	CRTC1	Island	0.2	0.0293	0.00000000000915	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12075928	chr8:141801307	8	141801307	PTK2	Open sea	-0.22	0.0323	0.0000000000097	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03655142	chr1:153950843	1	153950843	JTB	South shore	-0.15	0.022	0.00000000000994	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13916835	chr17:2078431	17	2078431	SMG6	Open sea	-0.24	0.0353	0.0000000000111	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04517079	chr6:41546161	6	41546161	FOXP4	Open sea	-0.13	0.0192	0.0000000000126	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11094248	chr17:38494580	17	38494580	RARA	North shelf	-0.11	0.0162	0.0000000000126	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19827923	chr2:231790777	2	231790777	GPR55	Open sea	-0.13	0.0192	0.0000000000127	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16398761	chr14:74220238	14	74220238	C14orf43	Open sea	-0.31	0.0459	0.0000000000141	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03519879	chr14:74227499	14	74227499	C14orf43	South shore	-0.1	0.0148	0.0000000000158	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02532700	chr22:37257404	22	37257404	NCF4	Open sea	-0.25	0.0374	0.0000000000222	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21393163	chr1:12217629	1	12217629	-	Open sea	-0.24	0.0359	0.000000000023	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08553327	chr6:31543647	6	31543647	TNF	Open sea	-0.2	0.0299	0.000000000023	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12547807	chr1:9473751	1	9473751	-	Open sea	-0.12	0.018	0.0000000000257	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26529655	chr5:424371	5	424371	AHRR	South shelf	-0.1	0.015	0.0000000000287	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01588224	chr1:153950867	1	153950867	JTB	South shore	-0.13	0.0196	0.0000000000315	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18236066	chr12:113293823	12	113293823	RPH3A	Open sea	-0.12	0.0181	0.0000000000378	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11739148	chr15:31622112	15	31622112	KLF13	South shore	-0.11	0.0166	0.0000000000379	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15187398	chr19:2093896	19	2093896	MOBKL2A	North shore	-0.19	0.0288	0.0000000000396	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24540678	chr8:28258603	8	28258603	-	North shore	-0.17	0.0258	0.0000000000463	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23565821	chr6:33385056	6	33385056	CUTA	North shore	-0.14	0.0213	0.0000000000478	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18446336	chr7:2847575	7	2847575	GNA12	Open sea	-0.26	0.0398	0.0000000000645	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05673882	chr5:74862702	5	74862702	POLK	Open sea	-0.19	0.0291	0.0000000000658	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01765406	chr2:129231478	2	129231478	-	South shelf	-0.11	0.0169	0.000000000068	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24342283	chr11:118758603	11	118758603	CXCR5	Open sea	-0.12	0.0184	0.000000000073	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22441770	chr1:153929592	1	153929592	CRTC2	North shore	-0.11	0.0169	0.0000000000778	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09084200	chr11:134095863	11	134095863	VPS26B;NCAPD3	South shore	-0.12	0.0185	0.000000000091	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05824218	chr17:38499096	17	38499096	RARA	South shore	0.08	0.0124	0.0000000000955	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17863923	chr2:87170602	2	87170602	RGPD1;RGPD2	South shore	-0.1	0.0155	0.0000000000999	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08149865	chr8:21914600	8	21914600	EPB49	South shore	-0.15	0.0232	0.000000000101	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23681440	chr13:27498239	13	27498239	-	Open sea	-0.17	0.0263	0.000000000102	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19717773	chr7:2847554	7	2847554	GNA12	Open sea	-0.38	0.0589	0.000000000114	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06595162	chr21:40141040	21	40141040	NCRNA00114	Open sea	-0.12	0.0186	0.000000000114	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14796406	chr7:80547689	7	80547689	SEMA3C	North shore	-0.43	0.0669	0.000000000127	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24688690	chr5:345850	5	345850	AHRR	South shore	-0.08	0.0124	0.00000000013	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11436113	chr20:19191145	20	19191145	-	North shore	-0.11	0.0171	0.000000000131	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22851200	chr7:100465833	7	100465833	TRIP6	South shore	-0.18	0.0281	0.00000000014	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19197419	chr20:44441612	20	44441612	UBE2C	Island	-0.24	0.0374	0.000000000142	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04907244	chr7:22894795	7	22894795	SNORD93	South shore	-0.26	0.0406	0.000000000145	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07180646	chr1:15481541	1	15481541	TMEM51	South shore	-0.18	0.0281	0.000000000152	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05677062	chr12:123874707	12	123874707	SETD8	South shore	-0.16	0.025	0.000000000158	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01873977	chr8:125699897	8	125699897	MTSS1	Open sea	-0.22	0.0344	0.00000000016	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18660898	chr1:151030968	1	151030968	CDC42SE1;MLLT11	North shore	-0.17	0.0266	0.000000000173	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18146737	chr1:92946700	1	92946700	GFI1	Island	-1.02	0.1599	0.000000000177	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09469355	chr1:2161886	1	2161886	SKI	South shore	-0.12	0.0189	0.0000000002	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03358636	chr3:197474006	3	197474006	KIAA0226	North shelf	-0.2	0.0315	0.000000000205	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22904711	chr19:44278628	19	44278628	KCNN4	Island	-0.24	0.0378	0.000000000208	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13543915	chr9:134293793	9	134293793	-	Open sea	-0.1	0.0157	0.000000000212	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01763916	chr1:40849202	1	40849202	SMAP2	Open sea	-0.14	0.0221	0.000000000222	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14712058	chr19:16988083	19	16988083	SIN3B	North shore	-0.19	0.03	0.000000000239	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16290996	chr1:173835989	1	173835989	GAS5;SNORD78;SNORD76;SNORD77;SNORD44;SNORD79	North shore	-0.18	0.0284	0.000000000248	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02743070	chr10:80834309	10	80834309	ZMIZ1	South shelf	-0.13	0.0206	0.000000000252	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25560398	chr2:233252170	2	233252170	ECEL1P2	Island	-0.08	0.0127	0.000000000277	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05726935	chr14:105263522	14	105263522	AKT1	South shore	-0.1	0.0158	0.00000000028	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06457408	chr17:79827882	17	79827882	ARHGDIA	North shore	-0.1	0.0159	0.000000000295	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03547355	chr1:227003060	1	227003060	-	Open sea	-0.11	0.0175	0.00000000031	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09022230	chr7:5457225	7	5457225	TNRC18	North shore	-0.16	0.0254	0.000000000313	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01832549	chr1:19774989	1	19774989	CAPZB	Open sea	-0.14	0.0223	0.000000000325	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12593793	chr1:156074135	1	156074135	-	Open sea	-0.12	0.0191	0.000000000328	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12147622	chr10:74021432	10	74021432	-	South shore	-0.16	0.0255	0.000000000337	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10399789	chr1:92945668	1	92945668	GFI1	North shore	-0.18	0.0287	0.000000000349	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18405341	chr22:39918625	22	39918625	ATF4	South shore	-0.1	0.016	0.000000000368	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04202338	chr3:12882335	3	12882335	RPL32;SNORA7A	North shore	-0.11	0.0176	0.000000000378	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11624345	chr19:44278551	19	44278551	KCNN4	Island	-0.15	0.0241	0.000000000465	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04813697	chr10:22920025	10	22920025	PIP4K2A	Open sea	-0.15	0.0241	0.000000000475	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00007076	chr8:67342600	8	67342600	RRS1	North shore	-0.14	0.0225	0.000000000476	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21121843	chr4:3203982	4	3203982	HTT	Open sea	-0.2	0.0321	0.000000000485	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24287110	chr10:3824687	10	3824687	KLF6	South shore	-0.2	0.0322	0.000000000529	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08866634	chr5:175962338	5	175962338	RNF44	North shore	-0.18	0.0291	0.000000000589	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10965178	chr1:43766752	1	43766752	TIE1	North shelf	-0.13	0.021	0.000000000631	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02003272	chr13:50702719	13	50702719	-	North shore	-0.26	0.0421	0.000000000632	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13937905	chr12:53612551	12	53612551	RARG	North shore	-0.32	0.0518	0.000000000636	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26995224	chr12:121974146	12	121974146	KDM2B	North shore	-0.26	0.0421	0.000000000646	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19372602	chr1:156116207	1	156116207	-	Open sea	-0.17	0.0275	0.000000000651	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16541026	chr3:49026934	3	49026934	P4HTM	North shore	-0.13	0.021	0.000000000651	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09578155	chr11:68141470	11	68141470	LRP5	Open sea	-0.09	0.0146	0.000000000702	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08257009	chr14:94812770	14	94812770	-	Open sea	-0.16	0.026	0.000000000758	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00554421	chr7:1513368	7	1513368	INTS1	North shore	-0.1	0.0163	0.000000000857	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24556382	chr4:174173455	4	174173455	GALNT7	Open sea	-0.22	0.0359	0.000000000878	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20727233	chr7:97501946	7	97501946	ASNS	South shore	-0.12	0.0196	0.000000000888	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07465627	chr17:53167407	17	53167407	STXBP4	Open sea	-0.11	0.018	0.000000000909	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08101174	chr10:104196541	10	104196541	-	Open sea	-0.12	0.0196	0.000000000912	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12678834	chr11:118753662	11	118753662	CXCR5	Open sea	-0.09	0.0147	0.000000000923	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11082959	chr7:150778332	7	150778332	FASTK;TMUB1	Island	-0.12	0.0196	0.000000000946	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17025683	chr1:173836220	1	173836220	SNORD78;ZBTB37;SNORD75;SNORD76;GAS5;SNORD77;SNORD44	North shore	-0.22	0.036	0.00000000103	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01478234	chr12:107975299	12	107975299	BTBD11	Island	-0.19	0.0312	0.0000000011	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26703507	chr2:113404661	2	113404661	SLC20A1	South shore	-0.18	0.0296	0.00000000112	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06321596	chr16:17562960	16	17562960	XYLT1	Open sea	-0.18	0.0296	0.00000000124	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg27514333	chr15:66996626	15	66996626	SMAD6	South shore	-0.15	0.0247	0.00000000129	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26196424	chr14:58615960	14	58615960	C14orf37	North shelf	-0.18	0.0297	0.00000000132	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19713429	chr1:19810690	1	19810690	CAPZB	North shore	-0.17	0.0281	0.00000000146	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14120703	chr9:139416102	9	139416102	NOTCH1	North shore	-0.09	0.0149	0.00000000148	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08763102	chr4:3079751	4	3079751	HTT	South shelf	-0.08	0.0133	0.00000000169	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01919999	chr5:180668568	5	180668568	GNB2L1	North shore	-0.13	0.0216	0.00000000169	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21091547	chr6:36645500	6	36645500	CDKN1A	North shore	-0.22	0.0365	0.00000000169	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05051464	chr1:19811322	1	19811322	CAPZB	North shore	-0.07	0.0116	0.00000000173	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06294803	chr3:184033282	3	184033282	EIF4G1	South shore	-0.16	0.0266	0.00000000175	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09658497	chr7:2847517	7	2847517	GNA12	Open sea	-0.43	0.0715	0.00000000178	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07265588	chr4:6574480	4	6574480	-	North shelf	-0.13	0.0216	0.00000000185	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24931658	chr8:21914524	8	21914524	EPB49	Island	-0.12	0.02	0.00000000185	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10691866	chr7:65817282	7	65817282	TPST1	Open sea	-0.19	0.0316	0.00000000193	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02810967	chr4:17813558	4	17813558	NCAPG;DCAF16	South shore	-0.15	0.025	0.000000002	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24323726	chr3:111314186	3	111314186	ZBED2;CD96	Open sea	-0.08	0.0134	0.00000000216	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03929796	chr3:52231840	3	52231840	ALAS1	North shore	-0.19	0.0318	0.00000000218	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15677364	chr6:30687221	6	30687221	TUBB	North shore	-0.14	0.0234	0.00000000221	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14034325	chr10:43891459	10	43891459	HNRNPF	North shore	-0.15	0.0251	0.00000000224	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17417856	chr19:50191637	19	50191637	PRMT1;C19orf76	North shore	-0.12	0.0201	0.00000000226	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21201657	chr19:5624574	19	5624574	SAFB	South shore	-0.1	0.0167	0.0000000023	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04158018	chr12:54696210	12	54696210	NFE2	Open sea	-0.15	0.0251	0.00000000242	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19309676	chr19:50191439	19	50191439	C19orf76;PRMT1	Island	-0.13	0.0218	0.00000000245	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20886049	chr11:76493545	11	76493545	TSKU	North shore	-0.13	0.0218	0.00000000248	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25212025	chr10:34602937	10	34602937	PARD3	Open sea	-0.17	0.0285	0.00000000257	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13518625	chr8:29522838	8	29522838	-	Open sea	-0.31	0.0521	0.00000000263	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24719910	chr3:30691493	3	30691493	TGFBR2	Open sea	-0.22	0.037	0.00000000264	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16794579	chr16:17562419	16	17562419	XYLT1	Open sea	-0.13	0.0218	0.00000000266	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20059928	chr15:40361485	15	40361485	-	Open sea	-0.24	0.0404	0.00000000275	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01839993	chr10:74034644	10	74034644	DDIT4	Island	-0.15	0.0253	0.00000000289	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20303561	chr14:91881497	14	91881497	CCDC88C	North shore	-0.16	0.027	0.00000000314	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21698310	chr17:48224718	17	48224718	PPP1R9B	North shore	-0.14	0.0236	0.00000000321	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04039799	chr11:19745484	11	19745484	NAV2	Open sea	-0.11	0.0186	0.00000000349	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05655806	chr3:111260756	3	111260756	CD96	Open sea	-0.22	0.0373	0.00000000384	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01017464	chr18:47018095	18	47018095	SNORD58A;SNORD58B;RPL17	North shore	-0.18	0.0306	0.00000000396	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07113006	chr1:45097282	1	45097282	RNF220	Island	-0.18	0.0306	0.00000000405	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18033416	chr17:30592033	17	30592033	RHBDL3	North shore	-0.14	0.0238	0.00000000411	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18826637	chr2:145116633	2	145116633	-	Open sea	-0.3	0.051	0.00000000414	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22870429	chr3:114027859	3	114027859	TIGIT	Open sea	-0.12	0.0204	0.00000000415	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01513913	chr14:106329158	14	106329158	-	Open sea	-0.12	0.0204	0.00000000415	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13985437	chr11:76381044	11	76381044	LRRC32	North shore	-0.14	0.0238	0.00000000429	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21746120	chr11:68142234	11	68142234	LRP5	Open sea	-0.07	0.0119	0.00000000452	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26729380	chr6:31543655	6	31543655	TNF	Open sea	-0.2	0.0341	0.00000000465	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00214171	chr17:73642991	17	73642991	RECQL5;LOC100130933	Open sea	-0.09	0.0154	0.00000000479	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07805542	chr1:9779309	1	9779309	PIK3CD	South shelf	-0.2	0.0342	0.00000000483	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11621113	chr19:12776725	19	12776725	MORG1;MAN2B1	North shore	-0.13	0.0222	0.00000000508	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12761472	chr6:119031922	6	119031922	-	Open sea	-0.18	0.0309	0.00000000547	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11152412	chr15:74927688	15	74927688	EDC3	Open sea	-0.13	0.0223	0.00000000548	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00324097	chr17:75446549	17	75446549	SEPT9	North shore	-0.09	0.0154	0.0000000055	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15344028	chr2:204801510	2	204801510	ICOS	Open sea	-0.2	0.0343	0.00000000567	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10179300	chr5:14147618	5	14147618	TRIO	South shelf	-0.19	0.0326	0.00000000582	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14074174	chr19:7986206	19	7986206	SNAPC2	South shore	-0.09	0.0155	0.00000000591	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15036326	chr17:27048708	17	27048708	RPL23A;SNORD4A	South shore	-0.11	0.0189	0.00000000611	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02767093	chr13:99130655	13	99130655	STK24	South shelf	-0.07	0.012	0.00000000614	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19825437	chr3:169383292	3	169383292	-	North shelf	-0.15	0.0258	0.00000000616	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20131596	chr5:102201128	5	102201128	PAM	North shore	-0.1	0.0172	0.00000000619	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01208318	chr14:106329652	14	106329652	-	North shelf	-0.24	0.0413	0.00000000619	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16736826	chr1:41951512	1	41951512	EDN2	Open sea	-0.08	0.0138	0.00000000638	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03999941	chr5:957511	5	957511	-	North shore	-0.19	0.0327	0.0000000064	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25953130	chr10:63753550	10	63753550	ARID5B	Open sea	-0.21	0.0362	0.00000000652	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19918734	chr11:86343931	11	86343931	ME3	Open sea	-0.12	0.0207	0.0000000069	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11556164	chr7:110738315	7	110738315	LRRN3;IMMP2L	Open sea	-0.2	0.0345	0.00000000697	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22407942	chr7:22894828	7	22894828	SNORD93	South shore	-0.2	0.0345	0.00000000709	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03147185	chr2:97008030	2	97008030	NCAPH	Open sea	-0.08	0.0138	0.0000000073	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10190813	chr7:48018530	7	48018530	HUS1	North shore	-0.21	0.0363	0.00000000755	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13832201	chr17:19282521	17	19282521	MAPK7	Island	-0.12	0.0208	0.00000000777	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01293143	chr20:62688326	20	62688326	TCEA2	North shore	-0.11	0.0191	0.0000000078	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00540464	chr19:16655751	19	16655751	-	South shelf	-0.17	0.0295	0.00000000786	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26337070	chr2:85999873	2	85999873	ATOH8	Open sea	-0.26	0.0451	0.0000000079	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03140521	chr1:68299388	1	68299388	GNG12	South shore	-0.15	0.026	0.00000000834	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13784312	chr9:134609065	9	134609065	RAPGEF1	Open sea	-0.21	0.0365	0.00000000843	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18474153	chr19:3984323	19	3984323	EEF2	North shore	-0.12	0.0209	0.00000000869	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04929932	chr1:91195683	1	91195683	-	South shelf	-0.17	0.0295	0.00000000876	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08737116	chr1:116563487	1	116563487	SLC22A15	Open sea	-0.15	0.0261	0.00000000882	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21445230	chr16:67969367	16	67969367	PSMB10	Island	-0.1	0.0174	0.00000000896	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01668352	chr12:64482597	12	64482597	SRGAP1	Open sea	-0.15	0.0261	0.00000000902	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03117379	chr20:17943971	20	17943971	SNORD17;SNX5	Open sea	-0.11	0.0191	0.00000000906	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08354053	chr17:30630872	17	30630872	RHBDL3	Open sea	-0.1	0.0174	0.00000000926	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05721773	chr1:207083336	1	207083336	FAIM3	South shore	-0.07	0.0122	0.00000000957	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06338710	chr1:92946187	1	92946187	GFI1	Island	-0.22	0.0383	0.00000000957	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21913886	chr1:15485346	1	15485346	TMEM51	South shelf	-0.21	0.0366	0.00000000958	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10919522	chr14:74227441	14	74227441	C14orf43	South shore	-0.18	0.0314	0.0000000096	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07151117	chr8:29204954	8	29204954	DUSP4	North shore	-0.11	0.0192	0.00000000995	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10788371	chr11:76381040	11	76381040	LRRC32	North shore	-0.14	0.0245	0.0000000103	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24996979	chr14:74223355	14	74223355	C14orf43	North shelf	-0.13	0.0227	0.0000000103	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13951797	chr16:2204381	16	2204381	TRAF7	North shore	-0.14	0.0245	0.0000000103	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04761231	chr9:127623571	9	127623571	RPL35	Island	-0.1	0.0175	0.0000000104	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01442064	chr4:5713450	4	5713450	EVC	Island	-0.1	0.0175	0.000000011	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09465703	chr16:733842	16	733842	JMJD8	Island	-0.24	0.042	0.0000000114	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07094298	chr4:2748026	4	2748026	TNIP2	Open sea	-0.23	0.0403	0.0000000116	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15059065	chr19:17354961	19	17354961	NR2F6	North shore	-0.38	0.0666	0.0000000116	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg15588941	chr3:48936565	3	48936565	SLC25A20	South shore	-0.09	0.0158	0.0000000117	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20813374	chr6:35657180	6	35657180	FKBP5	South shore	-0.1	0.0175	0.0000000117	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08682036	chr10:43898033	10	43898033	HNRNPF	Open sea	-0.1	0.0175	0.0000000121	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14571710	chr6:30655896	6	30655896	KIAA1949;NRM	South shore	-0.07	0.0123	0.0000000123	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26203136	chr7:739057	7	739057	PRKAR1B	Open sea	-0.16	0.0281	0.0000000123	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06762457	chr6:149806635	6	149806635	ZC3H12D	Open sea	-0.17	0.0299	0.0000000124	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03604424	chr5:14171590	5	14171590	TRIO	Open sea	-0.1	0.0176	0.0000000125	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16822666	chr17:35656660	17	35656660	ACACA	Open sea	-0.17	0.0299	0.0000000125	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12873476	chr8:142402728	8	142402728	-	South shore	-0.19	0.0334	0.0000000126	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17478749	chr6:31589365	6	31589365	SNORA38;BAT2	South shore	-0.15	0.0264	0.0000000128	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11927233	chr5:170816542	5	170816542	NPM1	South shore	-0.17	0.0299	0.0000000132	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03440944	chr7:45023329	7	45023329	C7orf40	North shelf	-0.11	0.0194	0.0000000132	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg27449150	chr1:118197326	1	118197326	-	Open sea	-0.14	0.0246	0.0000000134	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10814005	chr14:91711041	14	91711041	GPR68	Open sea	-0.2	0.0353	0.0000000142	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05789250	chr6:31804306	6	31804306	C6orf48;SNORD52	South shore	-0.2	0.0353	0.0000000143	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17551891	chr7:1960795	7	1960795	MAD1L1	Open sea	-0.22	0.0388	0.0000000146	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13092108	chr1:26857284	1	26857284	RPS6KA1	South shore	-0.08	0.0141	0.0000000147	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04011474	chr2:28904455	2	28904455	-	Open sea	-0.12	0.0212	0.0000000147	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18280057	chr8:125741158	8	125741158	MTSS1	Island	-0.18	0.0318	0.0000000147	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13541527	chr6:31804078	6	31804078	C6orf48;SNORD52	South shore	-0.23	0.0406	0.0000000148	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22740603	chr6:33397959	6	33397959	SYNGAP1	South shore	-0.09	0.0159	0.0000000149	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00489660	chr11:57089821	11	57089821	TNKS1BP1	North shore	-0.08	0.0141	0.0000000151	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01447748	chr1:51985259	1	51985259	EPS15	South shore	-0.14	0.0248	0.0000000157	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10678215	chr5:143191565	5	143191565	HMHB1	Open sea	0.17	0.0301	0.0000000159	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21618521	chr6:33245770	6	33245770	B3GALT4	South shore	-0.12	0.0212	0.0000000163	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03149958	chr6:36326677	6	36326677	-	Open sea	-0.2	0.0354	0.0000000164	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05329352	chr10:112838983	10	112838983	ADRA2A	Island	-0.19	0.0337	0.0000000165	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13127741	chr20:31331821	20	31331821	COMMD7	South shore	-0.12	0.0213	0.0000000173	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12655542	chr2:20357306	2	20357306	-	Open sea	-0.12	0.0213	0.0000000181	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06532880	chr5:176731545	5	176731545	PRELID1;RAB24	South shore	-0.17	0.0302	0.0000000181	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13583535	chr18:74768041	18	74768041	MBP	North shelf	-0.12	0.0213	0.0000000183	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21201109	chr19:11307090	19	11307090	KANK2	North shore	-0.11	0.0196	0.0000000186	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06178669	chr11:63334608	11	63334608	-	Open sea	-0.2	0.0356	0.0000000189	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17942851	chr1:36786285	1	36786285	C1orf113	North shore	0.1	0.0178	0.0000000192	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04388657	chr9:127623377	9	127623377	RPL35	North shore	-0.16	0.0285	0.0000000192	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13009654	chr5:137802252	5	137802252	EGR1	Island	-0.1	0.0178	0.0000000194	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11314684	chr1:244006288	1	244006288	AKT3	Open sea	-0.1	0.0178	0.0000000206	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24389054	chr7:27194013	7	27194013	HOXA7	North shore	-0.18	0.0321	0.0000000212	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10361922	chr17:40925790	17	40925790	VPS25	Open sea	-0.15	0.0268	0.0000000212	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05339037	chr19:13951168	19	13951168	-	North shelf	-0.09	0.0161	0.0000000225	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01005506	chr10:64565768	10	64565768	ADO	Island	-0.15	0.0268	0.0000000227	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13399816	chr1:68299468	1	68299468	GNG12	South shore	-0.16	0.0287	0.0000000235	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06154597	chr4:924812	4	924812	GAK;TMEM175	North shore	-0.11	0.0197	0.0000000241	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00024404	chr5:79552470	5	79552470	SERINC5	South shore	-0.16	0.0287	0.0000000243	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04759756	chr20:35273933	20	35273933	SLA2	Open sea	-0.09	0.0161	0.0000000246	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18801806	chr11:118869385	11	118869385	CCDC84	South shore	-0.08	0.0144	0.0000000248	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21140898	chr1:51442318	1	51442318	-	North shore	-0.23	0.0413	0.0000000252	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24086068	chr4:77356008	4	77356008	SHROOM3	Open sea	-0.2	0.0359	0.0000000252	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05958351	chr16:2804731	16	2804731	SRRM2	North shore	-0.09	0.0162	0.0000000266	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04535902	chr1:92947332	1	92947332	GFI1	Island	-0.53	0.0954	0.0000000274	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17333042	chr10:102822201	10	102822201	KAZALD1	Island	-0.1	0.018	0.0000000283	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01651915	chr8:55795551	8	55795551	-	Open sea	-0.25	0.0451	0.0000000291	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13745346	chr16:89044523	16	89044523	CBFA2T3	Open sea	-0.08	0.0144	0.0000000296	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03785076	chr2:241936915	2	241936915	SNED1	North shore	-0.1	0.0181	0.0000000311	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21500300	chr12:25102521	12	25102521	BCAT1	South shore	-0.13	0.0235	0.0000000312	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19868593	chr6:31744816	6	31744816	C6orf27	Open sea	-0.14	0.0253	0.0000000316	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25507845	chr5:149635694	5	149635694	CAMK2A	Open sea	-0.11	0.0199	0.0000000344	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06121808	chr2:113404678	2	113404678	SLC20A1	South shore	-0.14	0.0254	0.0000000345	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01272202	chr5:112716899	5	112716899	MCC	Open sea	-0.13	0.0236	0.0000000346	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03474926	chr9:136023407	9	136023407	RALGDS	North shore	-0.07	0.0127	0.0000000347	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01972009	chr11:67273431	11	67273431	PITPNM1	North shore	-0.11	0.0199	0.0000000348	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09069072	chr1:15482753	1	15482753	TMEM51	South shore	-0.43	0.078	0.0000000352	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18295744	chr10:80872926	10	80872926	ZMIZ1	Open sea	-0.09	0.0163	0.0000000352	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08396193	chr7:27193709	7	27193709	HOXA7	North shore	-0.19	0.0345	0.0000000373	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01744331	chr11:2722358	11	2722358	KCNQ1OT1;KCNQ1	South shore	-0.33	0.06	0.0000000377	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23574443	chr17:8263941	17	8263941	LOC100128288	Open sea	-0.17	0.0309	0.0000000386	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04962621	chr16:4714733	16	4714733	MGRN1	Open sea	-0.12	0.0218	0.0000000391	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08666707	chr6:41456441	6	41456441	-	Open sea	-0.09	0.0164	0.0000000396	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05228408	chr1:11865352	1	11865352	CLCN6;MTHFR	North shore	-0.09	0.0164	0.00000004	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14975410	chr3:171180070	3	171180070	-	South shore	-0.16	0.0292	0.0000000408	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20188739	chr8:67834756	8	67834756	SNORD87;SNHG6	North shelf	-0.11	0.0201	0.0000000412	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24741744	chr18:57564897	18	57564897	-	North shore	-0.18	0.0328	0.0000000419	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22998476	chr10:74058092	10	74058092	-	South shore	-0.11	0.0201	0.0000000428	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00830621	chr16:18799106	16	18799106	RPS15A	North shelf	-0.09	0.0164	0.0000000431	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22549408	chr18:57566300	18	57566300	PMAIP1	North shore	-0.2	0.0365	0.0000000437	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19098932	chr1:2345152	1	2345152	PEX10	North shore	-0.22	0.0402	0.0000000441	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03296761	chr22:30822510	22	30822510	MTP18	South shore	-0.11	0.0201	0.0000000446	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16708465	chr13:95933097	13	95933097	ABCC4	Open sea	-0.14	0.0256	0.0000000452	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20477259	chr6:31544960	6	31544960	TNF	North shelf	-0.09	0.0165	0.0000000453	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19713851	chr2:233246594	2	233246594	ALPP	South shore	-0.35	0.064	0.0000000464	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06060868	chr5:231934	5	231934	SDHA	Open sea	-0.13	0.0238	0.0000000467	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22628926	chr17:4844700	17	4844700	SLC25A11;RNF167	South shore	-0.11	0.0202	0.000000048	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10858677	chr15:49356663	15	49356663	-	Open sea	-0.14	0.0257	0.0000000495	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25007705	chr1:21588799	1	21588799	ECE1	Open sea	0.07	0.0128	0.0000000498	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13256912	chr3:11211081	3	11211081	HRH1	Open sea	-0.09	0.0165	0.0000000504	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00063111	chr3:39448952	3	39448952	SNORA6;RPSA	South shore	-0.22	0.0404	0.0000000516	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00639656	chr17:27050360	17	27050360	SNORD42A;RPL23A;SNORD4B	North shelf	-0.07	0.0129	0.0000000525	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01937809	chr1:37941854	1	37941854	ZC3H12A	South shore	-0.13	0.0239	0.0000000536	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06096184	chr3:66549732	3	66549732	LRIG1	North shore	-0.11	0.0202	0.0000000538	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20322193	chr7:39664614	7	39664614	RALA	South shore	-0.15	0.0276	0.000000054	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05616472	chr9:140514393	9	140514393	EHMT1;C9orf37	South shore	-0.11	0.0202	0.0000000541	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01999701	chr3:184456165	3	184456165	-	Open sea	-0.17	0.0313	0.0000000542	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02964434	chr15:31617537	15	31617537	-	North shore	-0.08	0.0147	0.0000000543	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00187059	chr6:33289693	6	33289693	DAXX	North shore	-0.1	0.0184	0.0000000544	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05886626	chr15:39873553	15	39873553	THBS1	Island	-0.16	0.0294	0.0000000552	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg27598208	chr20:62688272	20	62688272	TCEA2	North shore	-0.12	0.0221	0.0000000555	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23928726	chr1:2344998	1	2344998	PEX10	North shore	-0.14	0.0258	0.0000000573	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25103895	chr10:64565642	10	64565642	ADO	Island	-0.11	0.0203	0.0000000584	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23902550	chr8:144681106	8	144681106	EEF1D;TIGD5	Island	-0.08	0.0148	0.0000000602	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25596754	chr6:32026610	6	32026610	TNXB	Open sea	-0.26	0.048	0.0000000603	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09282085	chr22:39713086	22	39713086	RPL3;RNU86	North shelf	-0.08	0.0148	0.0000000617	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13633560	chr11:76380921	11	76380921	LRRC32	North shore	-0.14	0.0259	0.0000000622	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17372101	chr7:147500722	7	147500722	CNTNAP2	Open sea	0.13	0.024	0.0000000632	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg20912205	chr3:50337305	3	50337305	NAT6;HYAL3	South shore	-0.1	0.0185	0.0000000639	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01205831	chr9:130699236	9	130699236	DPM2	North shore	-0.1	0.0185	0.0000000647	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12364755	chr17:2498642	17	2498642	PAFAH1B1	South shore	-0.08	0.0148	0.0000000654	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18369034	chr14:52733216	14	52733216	PTGDR	North shore	-0.19	0.0352	0.0000000657	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02054431	chr6:31589593	6	31589593	SNORA38;BAT2	South shore	-0.12	0.0222	0.0000000664	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16702313	chr14:74251926	14	74251926	C14orf43	North shore	-0.08	0.0148	0.0000000664	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10790685	chr10:17269274	10	17269274	VIM	North shore	-0.14	0.0259	0.000000068	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg24139443	chr17:74131549	17	74131549	-	North shelf	-0.17	0.0315	0.0000000683	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01604883	chr5:149674905	5	149674905	-	North shelf	-0.08	0.0148	0.0000000694	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00207731	chr15:91416118	15	91416118	FURIN	South shore	-0.12	0.0223	0.0000000706	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05802386	chr1:43422920	1	43422920	SLC2A1	North shore	-0.13	0.0241	0.0000000719	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09479241	chr17:27052676	17	27052676	TLCD1	North shore	-0.31	0.0576	0.0000000727	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18676273	chr7:41732833	7	41732833	INHBA;LOC285954	Open sea	-0.12	0.0223	0.0000000735	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07512814	chr19:11203661	19	11203661	LDLR	South shore	-0.18	0.0334	0.0000000736	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02325250	chr5:131409289	5	131409289	CSF2	Open sea	-0.1	0.0186	0.0000000742	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg17087741	chr2:233283010	2	233283010	-	North shore	-0.45	0.0837	0.0000000747	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg22499893	chr1:24307535	1	24307535	SFRS13A	South shore	-0.14	0.026	0.0000000753	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26718213	chr2:241976080	2	241976080	SNED1	Island	0.35	0.0651	0.0000000766	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16646054	chr5:150157726	5	150157726	C5orf62	North shore	-0.11	0.0205	0.0000000766	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00931843	chr6:155442993	6	155442993	TIAM2	Open sea	0.17	0.0316	0.0000000768	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12033822	chr20:44990591	20	44990591	SLC35C2	North shelf	-0.07	0.013	0.0000000773	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26470501	chr19:45252955	19	45252955	BCL3	South shore	-0.09	0.0168	0.0000000779	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06223834	chr16:4103161	16	4103161	ADCY9	Open sea	-0.56	0.1043	0.00000008	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21747070	chr5:957535	5	957535	-	North shore	-0.15	0.028	0.0000000814	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg03340878	chr6:27925166	6	27925166	OR2B6	Open sea	-0.16	0.0299	0.0000000832	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02417427	chr5:79479211	5	79479211	SERINC5	Open sea	-0.09	0.0168	0.0000000846	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08170227	chr14:69422517	14	69422517	ACTN1	Open sea	-0.13	0.0243	0.0000000866	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25451120	chr17:47287444	17	47287444	ABI3;GNGT2	Open sea	-0.1	0.0187	0.0000000868	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05397202	chr1:1245040	1	1245040	PUSL1	Island	-0.09	0.0168	0.0000000875	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg26158528	chr1:28607681	1	28607681	SESN2	Open sea	-0.1	0.0187	0.0000000894	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00534655	chr5:139492727	5	139492727	PURA	Island	-0.08	0.015	0.0000000906	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg14014731	chr9:19378679	9	19378679	RPS6	North shore	-0.19	0.0356	0.0000000909	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg23892690	chr2:201675739	2	201675739	BZW1	North shore	-0.15	0.0281	0.0000000924	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02315870	chr7:26236721	7	26236721	HNRNPA2B1	North shelf	-0.08	0.015	0.0000000924	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg16357582	chr1:201476557	1	201476557	CSRP1	South shore	-0.09	0.0169	0.0000000933	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02917867	chr19:1265999	19	1265999	-	Island	-0.11	0.0206	0.0000000936	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg10237088	chr20:30794611	20	30794611	POFUT1;PLAGL2	North shore	-0.1	0.0187	0.0000000945	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06890522	chr17:6917393	17	6917393	RNASEK;C17orf49	North shore	-0.12	0.0225	0.0000000947	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18857467	chr1:32787489	1	32787489	HDAC1	Open sea	-0.16	0.03	0.0000000949	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12406027	chr19:39616818	19	39616818	PAK4	Island	-0.09	0.0169	0.0000000958	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg07945582	chr7:26206579	7	26206579	NFE2L3	Open sea	-0.13	0.0244	0.0000000963	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg02385153	chr5:404766	5	404766	AHRR;LOC100310782	Open sea	0.14	0.0263	0.0000000971	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05343105	chr16:29801371	16	29801371	KIF22	North shore	-0.11	0.0206	0.0000000971	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11794215	chr17:35423816	17	35423816	-	Open sea	-0.19	0.0357	0.0000000998	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13657200	chr9:117266029	9	117266029	DFNB31	North shore	-0.08	0.015	0.0000001	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05603985	chr1:2161049	1	2161049	SKI	Island	-0.09	0.0169	0.000000102	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg12554573	chr3:51976667	3	51976667	PARP3;RRP9	South shore	-0.1	0.0188	0.000000102	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg00566320	chr1:32172204	1	32172204	-	South shelf	-0.1	0.0188	0.000000104	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25998745	chr8:142028625	8	142028625	-	Open sea	-0.15	0.0282	0.000000106	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg11130692	chr8:141643919	8	141643919	EIF2C2	North shore	-0.08	0.0151	0.000000107	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08262002	chr4:16575323	4	16575323	LDB2	Open sea	-0.11	0.0207	0.000000108	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg04945608	chr20:43118723	20	43118723	TTPAL	Open sea	-0.12	0.0226	0.000000108	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg08893087	chr1:93416982	1	93416982	FAM69A	Open sea	-0.18	0.0339	0.000000109	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg25799109	chr3:57102900	3	57102900	ARHGEF3;SPATA12	Open sea	-0.19	0.0358	0.000000109	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg19483007	chr3:149327651	3	149327651	WWTR1	Open sea	-0.12	0.0226	0.00000011	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg13708645	chr12:121974305	12	121974305	KDM2B	North shore	-0.14	0.0264	0.000000111	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg09931909	chr6:74160206	6	74160206	C6orf150	North shore	-0.23	0.0433	0.000000112	-	25556184_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg18352916	chr6:33387089	6	33387089	CUTA;SYNGAP1	South shore	-0.09	0.017	0.000000114	-	25556184_smoking_current_vs_never_smoking