author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07741821	chr7:26577897	7	26577897	KIAA0087	Open sea	-0.3094	0.0299	3.6999999999999996e-25	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23565347	chr1:151672762	1	151672762	CELF3	Open sea	-0.1516	0.0164	1.9e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18062916	chr6:8839870	6	8839870	-	Open sea	-0.1426	0.0154	2.1e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08849601	chr2:135183637	2	135183637	MGAT5	Open sea	-0.1265	0.0137	3.3e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24999883	chr14:99880641	14	99880641	SETD3	Open sea	-0.1183	0.0129	3.6e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16831070	chr17:37721046	17	37721046	-	Open sea	-0.11	0.012	5.5e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11972401	chr2:10830636	2	10830636	NOL10	South shore	0.1034	0.0113	5.9e-20	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02680932	chr1:110437204	1	110437204	-	Open sea	-0.1299	0.0144	1.5e-19	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11151981	chr3:16560711	3	16560711	-	Open sea	-0.1103	0.0123	3.1e-19	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17831791	chr10:126712230	10	126712230	CTBP2	Island	-0.1431	0.0161	6.5e-19	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25589972	chr14:99829252	14	99829252	-	Open sea	-0.1593	0.0181	1.3e-18	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21731862	chr10:15894004	10	15894004	FAM188A	Open sea	-0.1261	0.0144	2.3e-18	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05042697	chr2:10830656	2	10830656	NOL10	South shore	0.0576	0.0066	3e-18	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01376763	chr16:81925132	16	81925132	PLCG2	Open sea	-0.1424	0.0164	3e-18	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07574178	chr5:80484747	5	80484747	RASGRF2	Open sea	-0.107	0.0125	1.4e-17	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08898211	chr2:110970909	2	110970909	LINC00116	South shore	-0.1005	0.0118	1.6e-17	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17349315	chr12:48188182	12	48188182	HDAC7	Open sea	-0.1469	0.0173	2.5e-17	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04131721	chr10:121013657	10	121013657	GRK5	Open sea	-0.1397	0.0166	3.4e-17	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12477880	chr21:36259241	21	36259241	RUNX1	Island	0.4041	0.048	3.9e-17	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09777776	chr19:24269890	19	24269890	ZNF254	Open sea	0.1156	0.014	1.4e-16	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22488975	chr1:184724009	1	184724009	EDEM3	Island	0.0266	0.0032	2.3e-16	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13382072	chr19:1851882	19	1851882	-	Island	0.2031	0.025	4e-16	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23719650	chr3:193988507	3	193988507	-	South shore	-0.1285	0.016	8.7e-16	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02993069	chr1:36786777	1	36786777	C1orf113	Island	0.1821	0.0227	0.000000000000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23198222	chr22:45071416	22	45071416	PRR5	Open sea	-0.1753	0.022	0.0000000000000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11218872	chr3:193988737	3	193988737	-	South shore	-0.1349	0.0171	0.0000000000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07841633	chr10:85363826	10	85363826	-	Open sea	-0.3443	0.0441	0.000000000000006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07989298	chr17:63074896	17	63074896	-	Open sea	-0.1284	0.0165	0.0000000000000069	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14626029	chr6:130704336	6	130704336	TMEM200A	Open sea	-0.132	0.0172	0.000000000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16181315	chr1:6687052	1	6687052	THAP3	South shore	-0.1369	0.018	0.000000000000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03142697	chr21:36258497	21	36258497	RUNX1	North shore	0.4332	0.0575	0.000000000000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00994804	chr21:36259383	21	36259383	RUNX1	Island	0.4115	0.0549	0.000000000000068	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19030331	chr11:7519636	11	7519636	OLFML1	Open sea	0.1668	0.0228	0.00000000000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23463008	chr3:179598680	3	179598680	PEX5L	Open sea	-0.0717	0.0099	0.00000000000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11434705	chr19:1851995	19	1851995	-	Island	0.208	0.0291	0.00000000000083	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08118908	chr16:15787920	16	15787920	NDE1	Open sea	-0.0965	0.0135	0.00000000000086	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06758350	chr21:36259460	21	36259460	RUNX1	Island	0.3077	0.043	0.00000000000088	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24942416	chr11:124621829	11	124621829	VSIG2	Open sea	-0.1644	0.023	0.0000000000009	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13860849	chr11:66084469	11	66084469	CD248	Island	0.1361	0.0192	0.0000000000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22743917	chr10:79264914	10	79264914	KCNMA1	Open sea	-0.1494	0.0212	0.0000000000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08730778	chr16:15787957	16	15787957	NDE1	Open sea	-0.1022	0.0145	0.0000000000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04599341	chr16:2029855	16	2029855	NOXO1	Island	0.2112	0.03	0.000000000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08882472	chr6:56607099	6	56607099	DST	Open sea	0.1503	0.0214	0.0000000000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27141801	chr16:70366767	16	70366767	DDX19B;LOC100506083	Open sea	0.0829	0.0119	0.0000000000028	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05289022	chr2:98377864	2	98377864	TMEM131	Open sea	-0.1675	0.0241	0.0000000000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08516535	chr22:46001327	22	46001327	LINC01589	Open sea	-0.1684	0.0243	0.000000000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19904322	chr21:45249837	21	45249837	-	South shelf	-0.1085	0.0157	0.0000000000044	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23097155	chr12:133066069	12	133066069	FBRSL1	Island	0.0617	0.0089	0.0000000000045	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27131667	chr16:89619402	16	89619402	SPG7	Open sea	-0.1113	0.0161	0.0000000000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02451831	chr7:26578098	7	26578098	KIAA0087	Open sea	-0.1603	0.0232	0.0000000000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08620751	chr19:1851750	19	1851750	-	Island	0.1489	0.0216	0.0000000000055	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16932827	chr3:193988639	3	193988639	-	South shore	-0.1096	0.016	0.0000000000065	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21585414	chr21:31121163	21	31121163	GRIK1-AS1;GRIK1	Open sea	-0.1261	0.0184	0.0000000000078	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17944412	chr16:2029938	16	2029938	NOXO1	Island	0.1402	0.0206	0.0000000000095	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00173498	chr8:61912461	8	61912461	-	Open sea	0.0766	0.0112	0.0000000000096	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12679760	chr1:36786615	1	36786615	C1orf113	Island	0.1725	0.0254	0.000000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12868449	chr13:99483755	13	99483755	DOCK9-AS1;DOCK9	Open sea	-0.1334	0.0197	0.000000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14886629	chr3:10333655	3	10333655	GHRL;GHRLOS	Open sea	-0.1505	0.0226	0.000000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02705918	chr12:114087236	12	114087236	-	Open sea	0.1745	0.0262	0.000000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01517789	chr10:108342212	10	108342212	SORCS1	Open sea	0.1173	0.0176	0.000000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16735956	chr6:36932863	6	36932863	-	South shelf	-0.1041	0.0156	0.000000000029	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00194325	chr2:159940344	2	159940344	TANC1	Open sea	-0.0565	0.0085	0.000000000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04790209	chr2:7274020	2	7274020	-	Open sea	-0.1504	0.0227	0.000000000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26974661	chr21:36258596	21	36258596	RUNX1	North shore	0.36	0.0548	0.000000000052	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11824827	chr16:31075547	16	31075547	ZNF668	Island	-0.1468	0.0224	0.000000000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18077307	chr2:98377791	2	98377791	TMEM131	Open sea	-0.2494	0.0381	0.00000000006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22539182	chr10:850393	10	850393	-	North shore	-0.1505	0.0233	0.00000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12172721	chr14:61822809	14	61822809	PRKCH	Open sea	0.1602	0.0248	0.00000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19672982	chr11:2715154	11	2715154	KCNQ1;KCNQ1OT1	Open sea	-0.0626	0.0098	0.00000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01521436	chr2:113542384	2	113542384	IL1A	Open sea	0.1184	0.0184	0.00000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20418711	chr21:36259179	21	36259179	RUNX1	Island	0.2454	0.0383	0.00000000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20866256	chr12:2902218	12	2902218	-	North shore	-0.1524	0.0239	0.00000000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24020235	chr8:37575051	8	37575051	LOC101929622	Open sea	0.1717	0.0269	0.00000000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09424382	chr4:34735270	4	34735270	-	Open sea	-0.0361	0.0057	0.0000000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13006424	chr2:98377939	2	98377939	TMEM131	Open sea	-0.1931	0.0304	0.00000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10127530	chr21:44732886	21	44732886	-	Open sea	-0.1145	0.018	0.00000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26642540	chr16:89010147	16	89010147	CBFA2T3	South shore	-0.0905	0.0143	0.00000000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13112407	chr2:97204931	2	97204931	ARID5A	South shore	-0.0799	0.0126	0.00000000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10167235	chr14:100807646	14	100807646	WARS	Open sea	0.0965	0.0152	0.00000000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24421519	chr21:34763007	21	34763007	-	Open sea	-0.0783	0.0125	0.00000000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17239923	chr11:128556611	11	128556611	-	North shelf	0.2132	0.034	0.00000000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09152042	chr6:33383065	6	33383065	PHF1	North shelf	-0.1266	0.0203	0.00000000048	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14369318	chr4:30759285	4	30759285	PCDH7	Open sea	0.079	0.0127	0.00000000051	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12732514	chr17:77726237	17	77726237	-	South shelf	0.1293	0.0209	0.00000000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20008885	chr1:193670163	1	193670163	-	Open sea	-0.138	0.0224	0.00000000067	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23497527	chr2:223269304	2	223269304	-	Open sea	0.0741	0.012	0.00000000069	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03996581	chr1:153586386	1	153586386	S100A16	Open sea	-0.134	0.0218	0.00000000076	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00598195	chr16:61922094	16	61922094	CDH8	Open sea	0.1946	0.0316	0.00000000076	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19635154	chr21:40326600	21	40326600	-	Open sea	-0.0774	0.0126	0.00000000089	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11673291	chr1:36787145	1	36787145	-	Island	0.1634	0.0267	0.0000000009	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22563815	chr15:78856949	15	78856949	CHRNA5	North shore	-0.1457	0.0239	0.0000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03868978	chr21:42537294	21	42537294	-	North shelf	-0.0777	0.0127	0.0000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01920382	chr1:60196606	1	60196606	FGGY	Open sea	0.1486	0.0244	0.0000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03335125	chr1:46088541	1	46088541	CCDC17	Island	-0.2282	0.0375	0.0000000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14937633	chr21:36259397	21	36259397	RUNX1	Island	0.2159	0.0356	0.0000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00238508	chr3:71907737	3	71907737	-	Open sea	-0.1591	0.0263	0.0000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06186330	chr17:46522513	17	46522513	-	Open sea	-0.0664	0.011	0.0000000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03850117	chr16:87894334	16	87894334	SLC7A5	North shore	0.0812	0.0134	0.0000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03724062	chr1:214746876	1	214746876	-	Open sea	0.1267	0.021	0.0000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13942119	chr12:13326748	12	13326748	-	Open sea	0.0987	0.0163	0.0000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11883814	chr9:134756631	9	134756631	MED27	Open sea	-0.0803	0.0133	0.0000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24520862	chr11:75943228	11	75943228	-	North shelf	-0.1391	0.0232	0.000000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19664945	chr2:54087343	2	54087343	LOC100302652;GPR75	South shore	-0.2859	0.0477	0.0000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02869559	chr21:36259067	21	36259067	RUNX1	Island	0.2425	0.0405	0.0000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04790662	chr8:82005985	8	82005985	PAG1	Open sea	0.2728	0.0456	0.0000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26983198	chr11:1952756	11	1952756	TNNT3	South shelf	0.1432	0.024	0.0000000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15877601	chr5:17797535	5	17797535	-	Open sea	-0.0973	0.0163	0.0000000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17139085	chr1:36787356	1	36787356	-	Island	0.2136	0.0359	0.0000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19161022	chr21:45344711	21	45344711	AGPAT3	Open sea	-0.0589	0.0099	0.0000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08257445	chr2:109997350	2	109997350	SH3RF3	Open sea	-0.1478	0.0249	0.0000000029	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06687305	chr1:46088486	1	46088486	CCDC17	Island	-0.24	0.0405	0.0000000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07277559	chr5:71814028	5	71814028	-	Open sea	0.1403	0.0237	0.0000000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12451530	chr2:54087209	2	54087209	LOC100302652;GPR75	Island	-0.2066	0.035	0.0000000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24179825	chr13:99483743	13	99483743	DOCK9-AS1;DOCK9	Open sea	-0.1195	0.0203	0.0000000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07741929	chr21:45249962	21	45249962	-	South shelf	-0.1085	0.0184	0.0000000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15856419	chr21:39760881	21	39760881	ERG	Open sea	-0.1074	0.0183	0.0000000044	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27496339	chr7:43803803	7	43803803	BLVRA	Open sea	0.2181	0.0372	0.0000000045	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09547880	chr2:113542393	2	113542393	IL1A	Open sea	0.0957	0.0163	0.0000000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26570867	chr16:12308181	16	12308181	SNX29	Open sea	-0.1547	0.0264	0.0000000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05725197	chr2:237734577	2	237734577	-	Open sea	-0.144	0.0246	0.000000005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14133557	chr9:113802005	9	113802005	-	South shore	-0.2022	0.0347	0.0000000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04348441	chr10:115955087	10	115955087	TDRD1	Open sea	-0.1487	0.0255	0.0000000055	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14727981	chr6:37074912	6	37074912	-	Open sea	-0.1227	0.0211	0.0000000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10537253	chr21:46542848	21	46542848	ADARB1	Open sea	-0.0979	0.0169	0.0000000065	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16026943	chr15:75641093	15	75641093	NEIL1	South shore	0.2162	0.0373	0.000000007	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07032852	chr9:140068071	9	140068071	-	North shore	0.1111	0.0192	0.0000000072	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23945483	chr21:45265007	21	45265007	-	Open sea	-0.073	0.0126	0.0000000074	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01635555	chr16:73101264	16	73101264	-	South shore	-0.1251	0.0216	0.0000000075	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01057898	chr22:19706868	22	19706868	SEPT5;SEPT5-GP1BB	South shore	0.1096	0.019	0.000000008	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00966672	chr21:45329952	21	45329952	AGPAT3	Open sea	-0.0913	0.0158	0.0000000083	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18891081	chr2:47382427	2	47382427	C2orf61	Open sea	-0.0958	0.0166	0.0000000084	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01566472	chr15:75641171	15	75641171	NEIL1	South shore	0.1235	0.0215	0.0000000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16059978	chr11:2308487	11	2308487	-	Open sea	0.2075	0.0362	0.0000000099	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19961545	chr2:54087066	2	54087066	GPR75;LOC100302652	Island	-0.1863	0.0326	0.00000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21532590	chr3:125903636	3	125903636	ALDH1L1-AS2	Open sea	0.0778	0.0136	0.00000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13609948	chr22:29427709	22	29427709	ZNRF3-AS1;ZNRF3	South shore	-0.1468	0.0257	0.000000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11763830	chr17:72231400	17	72231400	TTYH2	Open sea	0.1323	0.0232	0.000000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07746249	chr10:68721801	10	68721801	LOC101928961;LRRTM3;CTNNA3	Open sea	-0.1783	0.0313	0.000000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05014568	chr7:4873010	7	4873010	RADIL	North shore	-0.0755	0.0133	0.000000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02231211	chr6:14459102	6	14459102	-	Open sea	0.1212	0.0213	0.000000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08900851	chr3:130558275	3	130558275	-	Open sea	0.1359	0.0239	0.000000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12131208	chr17:58499700	17	58499700	C17orf64	South shore	0.2113	0.0373	0.000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17929770	chr19:46318514	19	46318514	RSPH6A	Island	0.1024	0.018	0.000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19765472	chr11:128556341	11	128556341	FLI1	North shelf	0.1802	0.0318	0.000000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06721796	chr20:44037519	20	44037519	DBNDD2;SYS1-DBNDD2	South shore	0.0877	0.0155	0.000000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24170424	chr11:8364582	11	8364582	-	Open sea	-0.0641	0.0113	0.000000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02910020	chr21:36883608	21	36883608	LOC100506403	Open sea	-0.088	0.0155	0.000000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10820980	chr13:99483730	13	99483730	DOCK9-AS1;DOCK9	Open sea	-0.1368	0.0242	0.000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02978008	chr2:47382666	2	47382666	C2orf61	Open sea	-0.1009	0.0179	0.000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04086778	chr6:6002190	6	6002190	NRN1	North shore	0.1144	0.0203	0.000000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02325250	chr5:131409289	5	131409289	CSF2	Open sea	-0.1126	0.02	0.000000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10080808	chr8:37574987	8	37574987	LOC101929622	Open sea	0.1043	0.0185	0.000000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06752482	chr17:58499816	17	58499816	C17orf64	South shore	0.0854	0.0152	0.000000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04467093	chr5:133448932	5	133448932	TCF7	North shore	0.1166	0.0208	0.00000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09973676	chr8:82006417	8	82006417	PAG1	Open sea	0.3123	0.0557	0.00000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06361984	chr16:15787940	16	15787940	NDE1	Open sea	-0.1395	0.0249	0.00000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16674433	chr17:19314408	17	19314408	RNF112	Open sea	-0.1821	0.0325	0.000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02197978	chr16:15796887	16	15796887	NDE1	Open sea	-0.0775	0.0138	0.000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00195322	chr20:48278559	20	48278559	B4GALT5	Open sea	-0.1215	0.0217	0.000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12329423	chr4:7628455	4	7628455	SORCS2	Open sea	0.2491	0.0444	0.000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00518702	chr6:113886046	6	113886046	-	Open sea	0.1166	0.0208	0.000000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12306427	chr6:13428245	6	13428245	GFOD1	Open sea	-0.1322	0.0236	0.000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15796437	chr21:29764998	21	29764998	-	Open sea	-0.093	0.0166	0.000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00891669	chr4:26814011	4	26814011	-	Open sea	-0.1065	0.019	0.000000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01145054	chr21:47063285	21	47063285	-	Island	-0.0093	0.0017	0.000000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19878627	chr2:54087184	2	54087184	LOC100302652;GPR75	Island	-0.1445	0.0259	0.000000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02773588	chr3:48698519	3	48698519	CELSR3	Island	0.1732	0.031	0.000000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06730285	chr5:139945107	5	139945107	APBB3;SLC35A4	South shore	-0.0916	0.0164	0.000000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07210082	chr2:20385524	2	20385524	-	Open sea	0.1244	0.0223	0.000000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03761216	chr1:51986130	1	51986130	EPS15	South shore	-0.0627	0.0113	0.000000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11240129	chr1:46088617	1	46088617	CCDC17	Island	-0.201	0.0361	0.000000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11075561	chr6:36088380	6	36088380	-	Open sea	-0.1983	0.0357	0.000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11615743	chr2:47382538	2	47382538	C2orf61	Open sea	-0.1512	0.0272	0.000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22345137	chr10:73358422	10	73358422	CDH23	Open sea	0.0802	0.0144	0.000000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02998028	chr2:135621153	2	135621153	ACMSD	Open sea	-0.1209	0.0218	0.00000003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02218324	chr19:46318439	19	46318439	RSPH6A	North shore	0.1113	0.0201	0.000000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22586493	chr2:110014556	2	110014556	SH3RF3	Open sea	-0.1389	0.0251	0.000000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18522909	chr2:47382903	2	47382903	C2orf61	Open sea	-0.1367	0.0248	0.000000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25857090	chr21:46975435	21	46975435	-	Island	-0.0181	0.0033	0.000000035	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02987388	chr1:46089045	1	46089045	CCDC17	Island	-0.2164	0.0393	0.000000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06598163	chr21:43965159	21	43965159	SLC37A1	Open sea	-0.0703	0.0128	0.000000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05414908	chr2:54087173	2	54087173	LOC100302652;GPR75	Island	-0.1248	0.0227	0.000000038	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07127410	chr22:29427851	22	29427851	ZNRF3	South shore	-0.1455	0.0265	0.000000038	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01332683	chr16:16190393	16	16190393	ABCC1	Open sea	0.1349	0.0246	0.00000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14561362	chr4:146461062	4	146461062	SMAD1	Open sea	0.0937	0.0171	0.000000041	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12226293	chr12:4333816	12	4333816	-	Open sea	0.1278	0.0234	0.000000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11197061	chr3:96988343	3	96988343	EPHA6	Open sea	0.1936	0.0354	0.000000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25054189	chr15:75641081	15	75641081	NEIL1	South shore	0.1116	0.0205	0.000000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08805869	chr4:169632391	4	169632391	PALLD	Open sea	0.1097	0.0201	0.000000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22993195	chr3:49756301	3	49756301	AMIGO3;RNF123	Island	0.2026	0.0372	0.00000005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08853223	chr12:132021299	12	132021299	-	Open sea	-0.0636	0.0117	0.000000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01210965	chr3:126259452	3	126259452	CHST13;C3orf22	North shore	0.1051	0.0193	0.000000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17178761	chr17:55682851	17	55682851	MSI2	Open sea	0.1586	0.0292	0.000000055	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02172058	chr17:58499911	17	58499911	C17orf64	South shore	0.1279	0.0236	0.000000057	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14501219	chr17:62775713	17	62775713	LOC146880	Island	0.1166	0.0215	0.000000057	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18464274	chr12:42537617	12	42537617	GXYLT1	North shore	0.0895	0.0165	0.000000058	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02393727	chr16:89690088	16	89690088	DPEP1	Open sea	0.1878	0.0346	0.000000058	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08096851	chr17:77726257	17	77726257	-	South shelf	0.1955	0.0361	0.00000006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26939946	chr17:19314395	17	19314395	RNF112	Open sea	-0.1862	0.0344	0.000000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25655189	chr14:78609989	14	78609989	-	Open sea	0.162	0.0299	0.000000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25073708	chr9:132083538	9	132083538	C9orf106	Island	0.1129	0.0209	0.000000064	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21929875	chr11:124622096	11	124622096	VSIG2	Open sea	-0.1516	0.028	0.000000064	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03446062	chr6:14477353	6	14477353	-	Open sea	0.1291	0.0239	0.000000066	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19696491	chr15:78857124	15	78857124	CHRNA5	North shore	-0.1404	0.026	0.000000069	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02727835	chr11:45940878	11	45940878	PEX16	South shore	-0.0818	0.0152	0.000000071	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22768430	chr6:26493808	6	26493808	-	Open sea	-0.0458	0.0085	0.000000074	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24238305	chr6:165959578	6	165959578	PDE10A	Open sea	-0.0385	0.0072	0.000000079	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07163687	chr9:129767752	9	129767752	RALGPS1	Open sea	0.0969	0.0181	0.000000082	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11287187	chr12:133413532	12	133413532	-	South shore	-0.2663	0.0497	0.000000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27489873	chr2:217088135	2	217088135	-	Open sea	-0.0992	0.0185	0.000000089	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07890839	chr15:67359525	15	67359525	SMAD3	South shore	0.0976	0.0182	0.00000009	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09889857	chr21:36259618	21	36259618	RUNX1	South shore	0.2404	0.045	0.000000092	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23636331	chr4:16087132	4	16087132	-	South shore	-0.1087	0.0203	0.000000093	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02212173	chr1:243876835	1	243876835	AKT3	Open sea	0.15	0.0281	0.000000095	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08611810	chr2:54087178	2	54087178	LOC100302652;GPR75	Island	-0.1523	0.0286	0.0000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12972300	chr15:70977671	15	70977671	UACA	Open sea	-0.1022	0.0192	0.0000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01876338	chr2:54087008	2	54087008	GPR75;LOC100302652	Island	-0.2207	0.0416	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25468618	chr8:144810034	8	144810034	FAM83H	Island	0.2082	0.0392	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19546057	chr11:128776216	11	128776216	C11orf45;KCNJ5	Open sea	0.1079	0.0203	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02156899	chr16:2029256	16	2029256	NOXO1	Island	0.162	0.0305	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00443981	chr17:58499679	17	58499679	C17orf64	South shore	0.1552	0.0293	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03890268	chr8:123502572	8	123502572	LOC105375734	Open sea	-0.0581	0.011	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22451408	chr21:45065904	21	45065904	HSF2BP	Open sea	-0.0698	0.0131	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15581537	chr7:23375935	7	23375935	IGF2BP3	Open sea	0.1755	0.0331	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00751179	chr2:158695297	2	158695297	ACVR1	Open sea	0.0756	0.0142	0.00000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01804934	chr6:33041229	6	33041229	HLA-DPA1	Open sea	0.1725	0.0327	0.00000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23258940	chr19:55995851	19	55995851	NAT14;ZNF628	Island	0.1075	0.0204	0.00000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06813295	chr21:46946981	21	46946981	SLC19A1	North shelf	-0.0388	0.0073	0.00000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10573232	chr12:119772533	12	119772533	CCDC60	Island	0.2423	0.0459	0.00000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13461447	chr1:1714001	1	1714001	-	Island	-0.1399	0.0266	0.00000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00701946	chr2:54087200	2	54087200	LOC100302652;GPR75	Island	-0.1641	0.0312	0.00000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04457572	chr10:73303234	10	73303234	CDH23	Open sea	0.0952	0.0182	0.00000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06871560	chr15:52944233	15	52944233	KIAA1370	Open sea	0.1734	0.033	0.00000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13483727	chr18:615471	18	615471	CLUL1	Open sea	0.1316	0.0251	0.00000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11155658	chr3:49506751	3	49506751	DAG1	North shore	-0.0713	0.0136	0.00000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10207218	chr1:1714140	1	1714140	-	Island	-0.0702	0.0134	0.00000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12083928	chr21:36259623	21	36259623	RUNX1	South shore	0.2236	0.0428	0.00000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22928020	chr21:39616836	21	39616836	KCNJ15	Open sea	-0.0856	0.0164	0.00000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11750580	chr1:46088336	1	46088336	CCDC17	Island	-0.1134	0.0218	0.0000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08935725	chr20:52224749	20	52224749	-	Open sea	-0.0797	0.0153	0.0000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17238473	chr2:98378600	2	98378600	TMEM131	Open sea	-0.0787	0.0151	0.0000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16291204	chr11:112885688	11	112885688	NCAM1	Open sea	-0.1139	0.0219	0.0000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24112628	chr6:150174215	6	150174215	LRP11	Open sea	-0.1449	0.0279	0.00000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11067407	chr11:113599852	11	113599852	-	Open sea	0.1059	0.0204	0.00000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17628249	chr17:58499854	17	58499854	C17orf64	South shore	0.1119	0.0215	0.00000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03952533	chr21:43679795	21	43679795	ABCG1	Open sea	-0.0795	0.0153	0.00000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01894844	chr20:52224849	20	52224849	-	Open sea	-0.0756	0.0146	0.00000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19063680	chr21:31121244	21	31121244	GRIK1-AS1;GRIK1	Open sea	-0.0927	0.0179	0.00000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08381798	chr22:29705045	22	29705045	GAS2L1	South shore	-0.0824	0.0159	0.00000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14980883	chr7:16835396	7	16835396	AGR2	Open sea	0.1915	0.037	0.00000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05142212	chr13:33563153	13	33563153	-	Open sea	0.1103	0.0214	0.00000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09409898	chr17:2169829	17	2169829	SMG6	Open sea	-0.1303	0.0253	0.00000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20619669	chr21:47659301	21	47659301	MCM3AP-AS1;MCM3AP	Open sea	-0.0458	0.0089	0.0000003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11041353	chr10:97240141	10	97240141	SORBS1	Open sea	-0.0942	0.0184	0.0000003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15969263	chr21:45287137	21	45287137	AGPAT3	Open sea	-0.0632	0.0123	0.00000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22470272	chr17:55631524	17	55631524	MSI2	Open sea	0.0804	0.0157	0.00000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13468961	chr2:172944338	2	172944338	MAP1D	North shore	-0.1559	0.0305	0.00000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14008974	chr8:131012240	8	131012240	FAM49B	Open sea	0.0853	0.0167	0.00000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10542562	chr11:128556382	11	128556382	-	North shelf	0.1626	0.0319	0.00000035	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12622863	chr14:95712746	14	95712746	CLMN	Open sea	-0.0894	0.0176	0.00000035	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16400145	chr21:46359118	21	46359118	LINC01547;FAM207A	North shore	-0.069	0.0136	0.00000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26818573	chr2:46717839	2	46717839	-	Open sea	0.1066	0.021	0.0000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19896824	chr11:128555529	11	128555529	-	Open sea	0.194	0.0383	0.00000041	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06808571	chr7:150642256	7	150642256	KCNH2	North shelf	0.1002	0.0198	0.00000043	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07491514	chr15:52944329	15	52944329	FAM214A	Open sea	0.1519	0.03	0.00000043	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06883267	chr5:71813961	5	71813961	-	Open sea	0.0992	0.0196	0.00000043	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21033715	chr21:28216125	21	28216125	ADAMTS1	North shore	-0.007	0.0014	0.00000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24069542	chr18:46469214	18	46469214	SMAD7	Open sea	-0.1339	0.0266	0.00000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04168235	chr16:75282179	16	75282179	BCAR1	North shelf	-0.1284	0.0255	0.00000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06977984	chr15:52944386	15	52944386	FAM214A	Open sea	0.1598	0.0318	0.00000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17697043	chr20:52224625	20	52224625	-	Open sea	-0.0756	0.0151	0.00000051	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15728109	chr10:12375952	10	12375952	-	Open sea	0.1022	0.0204	0.00000052	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08787837	chr16:86029554	16	86029554	-	Open sea	0.135	0.0269	0.00000053	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21122199	chr17:58499720	17	58499720	C17orf64	South shore	0.1002	0.02	0.00000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11704631	chr21:36395663	21	36395663	RUNX1	North shelf	0.0869	0.0174	0.00000055	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05381256	chr21:36089941	21	36089941	CLIC6	Open sea	-0.0523	0.0104	0.00000055	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12176783	chr20:62694000	20	62694000	TCEA2	Island	0.1805	0.0361	0.00000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07111846	chr21:43771349	21	43771349	TFF2	Open sea	-0.0649	0.013	0.00000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11195375	chr11:124622348	11	124622348	VSIG2	Open sea	-0.1052	0.021	0.00000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04154027	chr5:78985588	5	78985588	CMYA5	Open sea	-0.2488	0.0499	0.00000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04621850	chr9:140067121	9	140067121	TMEM210	North shore	0.1239	0.0249	0.00000062	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27165960	chr5:39177381	5	39177381	FYB	Open sea	-0.0802	0.0161	0.00000067	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12761707	chr21:43468534	21	43468534	-	Open sea	-0.0811	0.0163	0.00000067	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14023398	chr4:40633068	4	40633068	RBM47	South shore	0.1043	0.021	0.00000068	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24123198	chr4:184018031	4	184018031	-	North shore	0.1555	0.0313	0.0000007	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15074613	chr17:48604896	17	48604896	MYCBPAP	Open sea	0.0716	0.0144	0.0000007	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13003878	chr9:116840825	9	116840825	AMBP	Open sea	0.098	0.0198	0.00000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10692519	chr21:40342778	21	40342778	-	Open sea	-0.0752	0.0152	0.00000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09169132	chr2:171826682	2	171826682	-	North shelf	-0.0701	0.0142	0.00000074	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07145284	chr11:66084631	11	66084631	CD248	South shore	0.0681	0.0138	0.00000074	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23713900	chr18:615496	18	615496	CLUL1	Open sea	0.1076	0.0218	0.00000077	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11646706	chr3:58514483	3	58514483	ACOX2	Open sea	0.2166	0.0438	0.00000077	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04539934	chr3:41038791	3	41038791	-	Open sea	-0.0578	0.0117	0.00000077	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24287218	chr6:33041268	6	33041268	HLA-DPA1	Open sea	0.0785	0.0159	0.00000079	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19414967	chr8:49468296	8	49468296	-	North shore	0.0968	0.0196	0.00000082	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11949606	chr21:34096277	21	34096277	SYNJ1	North shelf	-0.055	0.0112	0.00000082	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21891597	chr8:132936123	8	132936123	EFR3A	Open sea	0.1474	0.0299	0.00000082	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15097669	chr12:56225116	12	56225116	TMEM198B	South shore	0.0904	0.0183	0.00000083	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15297650	chr2:135477056	2	135477056	TMEM163	South shore	0.0974	0.0198	0.00000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16835843	chr21:45363997	21	45363997	AGPAT3	South shore	-0.0652	0.0132	0.00000086	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02097604	chr17:17750910	17	17750910	TOM1L2	Open sea	-0.0908	0.0185	0.0000009	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25837377	chr9:37472460	9	37472460	-	Open sea	0.0957	0.0195	0.0000009	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23279355	chr5:78985592	5	78985592	CMYA5	Open sea	-0.2242	0.0457	0.00000092	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10330057	chr1:203005307	1	203005307	-	Open sea	-0.0686	0.014	0.00000094	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03654166	chr2:172944393	2	172944393	MAP1D	North shore	-0.1208	0.0247	0.00000099	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03920999	chr3:10334760	3	10334760	GHRLOS;GHRL	Open sea	-0.0485	0.0099	0.00000099	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24049884	chr10:102667200	10	102667200	-	Open sea	-0.0681	0.0139	0.00000099	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03119829	chr1:64170964	1	64170964	-	Open sea	0.1459	0.0298	0.000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15238694	chr12:119740840	12	119740840	LOC144742	Open sea	0.1434	0.0294	0.000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24436531	chr11:128556352	11	128556352	FLI1	North shelf	0.1849	0.0378	0.000001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22530055	chr21:45373097	21	45373097	AGPAT3	Open sea	-0.0493	0.0101	0.0000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03277268	chr7:151623360	7	151623360	-	Open sea	0.0916	0.0188	0.0000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06176777	chr21:39084502	21	39084502	KCNJ6	Open sea	-0.1536	0.0317	0.0000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04413853	chr17:58499706	17	58499706	C17orf64	South shore	0.1268	0.0262	0.0000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13758712	chr21:28218959	21	28218959	ADAMTS1	South shore	-0.0073	0.0015	0.0000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12171807	chr20:61914812	20	61914812	ARFGAP1	North shore	-0.0722	0.0149	0.0000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07042301	chr14:104338807	14	104338807	-	Open sea	-0.0611	0.0126	0.0000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18017575	chr7:75213863	7	75213863	HIP1	Open sea	0.0982	0.0203	0.0000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19859698	chr14:61822607	14	61822607	PRKCH	Open sea	0.1324	0.0274	0.0000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06546183	chr21:44257072	21	44257072	-	North shore	-0.0652	0.0135	0.0000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22510139	chr1:3058822	1	3058822	PRDM16	North shore	0.1062	0.0221	0.0000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00764652	chr21:42733397	21	42733397	MX2	Open sea	-0.045	0.0094	0.0000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03429644	chr2:9252446	2	9252446	-	Open sea	0.1426	0.0297	0.0000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12843033	chr21:45706043	21	45706043	AIRE	Island	-0.0928	0.0193	0.0000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20606301	chr17:9571882	17	9571882	USP43	Open sea	-0.1282	0.0267	0.0000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20488281	chr12:119772354	12	119772354	CCDC60	Island	0.1227	0.0256	0.0000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21023025	chr5:154172209	5	154172209	LARP1	Open sea	-0.076	0.0159	0.0000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03729276	chr10:112865659	10	112865659	-	Open sea	0.1056	0.0221	0.0000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26366371	chr1:245664079	1	245664079	KIF26B	Open sea	0.0949	0.0199	0.0000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10257870	chr5:78985484	5	78985484	CMYA5	Open sea	-0.2084	0.0437	0.0000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03400002	chr9:94266072	9	94266072	-	Open sea	0.0479	0.01	0.0000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22197811	chr22:38627189	22	38627189	TMEM184B	Open sea	-0.1582	0.0332	0.0000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05943655	chr6:43636172	6	43636172	RSPH9	Open sea	0.0516	0.0109	0.000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03214130	chr7:36088642	7	36088642	-	Open sea	0.0598	0.0126	0.000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01964774	chr21:39663949	21	39663949	KCNJ15	Open sea	-0.0753	0.0158	0.000002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09616647	chr3:183959171	3	183959171	VWA5B2;MIR1224	Island	0.1305	0.0276	0.0000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03847470	chr11:128556580	11	128556580	FLI1	North shelf	0.1578	0.0334	0.0000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21173328	chr3:11119246	3	11119246	-	Open sea	0.0737	0.0156	0.0000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26890182	chr2:135621176	2	135621176	ACMSD	Open sea	-0.1129	0.024	0.0000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21545762	chr3:183959118	3	183959118	VWA5B2;MIR1224	Island	0.136	0.0289	0.0000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08297686	chr14:68943486	14	68943486	RAD51L1	Open sea	0.0653	0.0139	0.0000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15629519	chr2:13793275	2	13793275	-	Open sea	-0.1891	0.0402	0.0000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00502597	chr1:60197222	1	60197222	FGGY	Open sea	0.0709	0.0151	0.0000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01590762	chr6:121914368	6	121914368	-	Open sea	0.1456	0.031	0.0000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23872513	chr11:112885708	11	112885708	NCAM1	Open sea	-0.1102	0.0235	0.0000027	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24485927	chr2:795989	2	795989	-	Open sea	0.1371	0.0293	0.0000028	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14886850	chr14:75122289	14	75122289	-	Open sea	-0.1045	0.0223	0.0000029	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09072231	chr21:30744759	21	30744759	BACH1-IT2	Open sea	-0.075	0.016	0.0000029	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02197387	chr20:62694005	20	62694005	TCEA2	Island	0.0991	0.0212	0.000003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22424909	chr13:113639318	13	113639318	MCF2L	South shelf	0.1004	0.0215	0.000003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04227885	chr17:2434802	17	2434802	-	Open sea	-0.1326	0.0284	0.0000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25500267	chr8:55121968	8	55121968	-	Open sea	0.1011	0.0217	0.0000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25614875	chr1:217263847	1	217263847	ESRRG	South shore	0.1684	0.0362	0.0000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07883622	chr12:62998134	12	62998134	C12orf61	South shore	0.0688	0.0148	0.0000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17595624	chr12:13246810	12	13246810	GSG1	Open sea	0.0897	0.0193	0.0000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09655403	chr5:78985495	5	78985495	CMYA5	Open sea	-0.2939	0.0633	0.0000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13863153	chr21:39628679	21	39628679	KCNJ15	Open sea	-0.0962	0.0208	0.0000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01808739	chr1:93912802	1	93912802	FNBP1L	North shore	0.1673	0.0362	0.0000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10490842	chr22:51016604	22	51016604	CPT1B;CHKB-CPT1B	Island	0.2342	0.0506	0.0000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24155444	chr1:155177969	1	155177969	MTX1;THBS3	North shore	0.0569	0.0123	0.0000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24425316	chr18:77400225	18	77400225	-	South shore	0.0849	0.0184	0.0000038	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10409832	chr2:98376193	2	98376193	TMEM131	Open sea	-0.0643	0.0139	0.0000038	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03727673	chr1:21966420	1	21966420	RAP1GAP	Open sea	-0.0678	0.0147	0.000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23799091	chr11:75365642	11	75365642	MAP6	Open sea	-0.0919	0.0199	0.000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00976623	chr14:69389034	14	69389034	ACTN1	Open sea	0.0665	0.0144	0.000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03237342	chr15:57425757	15	57425757	TCF12	Open sea	0.1099	0.0238	0.000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02521050	chr21:45287110	21	45287110	AGPAT3	Open sea	-0.0747	0.0162	0.000004	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03546977	chr5:78985489	5	78985489	CMYA5	Open sea	-0.1393	0.0303	0.0000043	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01230359	chr16:8728911	16	8728911	METTL22	Open sea	-0.0742	0.0161	0.0000043	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03944314	chr1:33827344	1	33827344	PHC2;LOC101929464	Open sea	-0.0622	0.0136	0.0000044	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15882363	chr16:9055758	16	9055758	USP7	North shore	-0.0442	0.0096	0.0000045	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24510074	chr7:128802865	7	128802865	TSPAN33	Open sea	-0.0946	0.0206	0.0000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04524370	chr22:22292919	22	22292919	PPM1F	South shore	-0.0484	0.0106	0.0000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11106793	chr2:103106125	2	103106125	SLC9A4	Open sea	-0.125	0.0273	0.0000048	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13746740	chr11:128554939	11	128554939	-	Open sea	0.1328	0.029	0.0000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23976034	chr7:69790830	7	69790830	AUTS2	Open sea	0.1033	0.0226	0.0000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17766654	chr15:52944269	15	52944269	FAM214A	Open sea	0.1908	0.0418	0.000005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08373904	chr11:1543275	11	1543275	HCCA2	Open sea	-0.0735	0.0161	0.0000052	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10742523	chr4:55650393	4	55650393	-	Open sea	0.0829	0.0182	0.0000053	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05381578	chr4:152595994	4	152595994	GATB	Open sea	-0.1151	0.0253	0.0000054	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12258307	chr21:32931935	21	32931935	TIAM1	Island	-0.0083	0.0018	0.0000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07741395	chr9:129254157	9	129254157	MVB12B	Open sea	-0.0444	0.0098	0.0000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23346329	chr1:90412171	1	90412171	-	Open sea	0.0627	0.0138	0.0000057	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05378523	chr11:128774371	11	128774371	C11orf45;KCNJ5	Open sea	-0.2075	0.0458	0.0000058	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01290904	chr4:5708474	4	5708474	EVC2	North shore	0.1093	0.0241	0.0000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01385679	chr20:45033155	20	45033155	ELMO2	North shore	-0.0686	0.0151	0.0000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16847377	chr4:3370988	4	3370988	RGS12	North shelf	0.075	0.0165	0.0000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07849827	chr1:15772154	1	15772154	CTRC	Open sea	-0.0819	0.0181	0.0000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26275598	chr8:124167044	8	124167044	-	North shore	-0.0788	0.0174	0.0000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23715045	chr11:124621944	11	124621944	VSIG2	Open sea	-0.1264	0.0279	0.000006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01026256	chr3:183959088	3	183959088	VWA5B2;MIR1224	Island	0.1835	0.0406	0.0000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13754720	chr9:98274853	9	98274853	PTCH1	South shore	0.1454	0.0322	0.0000062	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24886154	chr21:45138054	21	45138054	PDXK	North shore	-0.0429	0.0095	0.0000062	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10040866	chr15:72690640	15	72690640	TMEM202	Open sea	0.0783	0.0173	0.0000063	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11778548	chr1:155177963	1	155177963	MTX1;THBS3	North shore	0.0705	0.0156	0.0000065	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15946312	chr5:180646880	5	180646880	-	Island	0.1635	0.0363	0.0000068	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04283720	chr11:112834521	11	112834521	LOC101928847;NCAM1	South shore	0.1437	0.032	0.0000068	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02314852	chr6:111532870	6	111532870	SLC16A10	Open sea	0.157	0.0349	0.0000069	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05804288	chr16:17332576	16	17332576	XYLT1	Open sea	0.0897	0.02	0.000007	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19190699	chr15:101514156	15	101514156	LRRK1	Island	-0.0791	0.0176	0.0000071	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15197065	chr5:78985562	5	78985562	CMYA5	Open sea	-0.1881	0.0419	0.0000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03516335	chr11:72122809	11	72122809	CLPB	Open sea	0.0541	0.0121	0.0000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11456334	chr21:33506516	21	33506516	NCRNA00159	Open sea	0.0128	0.0029	0.000008	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10770023	chr22:51016644	22	51016644	CPT1B;CHKB-CPT1B	Island	0.3014	0.0676	0.0000082	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01966117	chr3:52528714	3	52528714	STAB1	Open sea	-0.0692	0.0155	0.0000083	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18369748	chr7:43541717	7	43541717	HECW1	Open sea	0.0825	0.0185	0.0000083	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05376738	chr1:212923780	1	212923780	NSL1	Open sea	0.0787	0.0177	0.0000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05826295	chr6:113886340	6	113886340	-	Open sea	0.1488	0.0334	0.0000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07854108	chr21:27011836	21	27011836	JAM2	Island	-0.0055	0.0012	0.0000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13597043	chr1:90165225	1	90165225	LRRC8C	Open sea	0.0844	0.019	0.0000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10472537	chr2:105348800	2	105348800	-	Open sea	0.0965	0.0217	0.0000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04659944	chr1:94684108	1	94684108	ARHGAP29	Open sea	-0.1535	0.0345	0.0000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06390490	chr22:38627184	22	38627184	TMEM184B	Open sea	-0.1689	0.038	0.0000089	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14035368	chr9:139258938	9	139258938	CARD9;DNLZ	Island	0.1716	0.0387	0.0000091	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26895804	chr8:145917243	8	145917243	-	Open sea	0.0784	0.0177	0.0000092	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18478353	chr21:43986783	21	43986783	SLC37A1	North shelf	-0.0614	0.0139	0.0000096	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19684059	chr21:47533179	21	47533179	COL6A2	South shore	-0.0776	0.0175	0.0000097	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17403995	chr1:52348865	1	52348865	-	South shelf	0.071	0.0161	0.00001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08411860	chr3:183959746	3	183959746	VWA5B2	Island	0.0964	0.0218	0.00001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14387452	chr9:20512334	9	20512334	MLLT3	Open sea	0.085	0.0193	0.00001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26037180	chr14:88199948	14	88199948	-	Open sea	-0.222	0.0503	0.00001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08975915	chr12:90050928	12	90050928	ATP2B1	Open sea	0.0923	0.0209	0.00001	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10316525	chr15:40572137	15	40572137	-	Island	-0.2104	0.0479	0.000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25552887	chr16:66751144	16	66751144	-	Open sea	-0.095	0.0216	0.000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11662039	chr5:99983746	5	99983746	-	Open sea	-0.0739	0.0168	0.000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg11731280	chr9:140066934	9	140066934	TMEM210	North shore	0.1253	0.0285	0.000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02626395	chr7:151615549	7	151615549	-	Open sea	0.0906	0.0206	0.000011	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14909179	chr11:882687	11	882687	CHID1	South shore	-0.1931	0.0441	0.000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25921609	chr17:8379225	17	8379225	MYH10	North shore	0.1528	0.0349	0.000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10023324	chr3:149780400	3	149780400	-	Open sea	0.1015	0.0232	0.000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15800404	chr21:37757105	21	37757105	CHAF1B	North shore	-0.0885	0.0202	0.000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12711754	chr14:71247286	14	71247286	MAP3K9	Open sea	0.0811	0.0185	0.000012	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17942851	chr1:36786285	1	36786285	C1orf113	North shore	0.1005	0.023	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14251734	chr10:100407378	10	100407378	HPSE2	Open sea	0.1217	0.0279	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06527213	chr15:86315211	15	86315211	KLHL25;MIR1276	South shelf	0.0691	0.0158	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01237541	chr10:85306289	10	85306289	-	Open sea	0.1687	0.0387	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09856696	chr19:16540019	19	16540019	EPS15L1	Open sea	-0.0799	0.0183	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06571187	chr1:209878123	1	209878123	HSD11B1	Open sea	0.0813	0.0186	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26916625	chr21:46385436	21	46385436	FAM207A	North shore	-0.1232	0.0283	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12226077	chr1:28641987	1	28641987	-	Open sea	-0.1483	0.0341	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22863298	chr1:9007541	1	9007541	CA6	Open sea	0.0485	0.0111	0.000013	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06746154	chr8:145137177	8	145137177	GPAA1	Island	0.0446	0.0103	0.000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20516845	chr21:43823604	21	43823604	UBASH3A	Open sea	-0.0496	0.0114	0.000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23218897	chr17:2169522	17	2169522	SMG6	Open sea	-0.0973	0.0224	0.000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14790806	chr18:43858598	18	43858598	-	Open sea	-0.0388	0.0089	0.000014	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10575367	chr16:2801914	16	2801914	LOC100128788;SRRM2	Island	-0.1165	0.0269	0.000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23837804	chr21:45221122	21	45221122	RRP1	North shelf	0.0144	0.0033	0.000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15285786	chr1:94559976	1	94559976	ABCA4	Open sea	0.0616	0.0142	0.000015	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06735127	chr12:124805929	12	124805929	-	North shelf	-0.0542	0.0126	0.000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02904657	chr15:40571997	15	40571997	-	North shore	-0.2117	0.049	0.000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg22866426	chr21:36263347	21	36263347	RUNX1	Island	0.1598	0.0371	0.000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02748800	chr18:24229920	18	24229920	KCTD1	Open sea	0.0399	0.0093	0.000016	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05347456	chr16:89690262	16	89690262	DPEP1	Open sea	0.202	0.047	0.000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg03135912	chr21:47531289	21	47531289	COL6A2	North shore	-0.0249	0.0058	0.000017	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17709804	chr11:128555749	11	128555749	-	Open sea	0.0961	0.0224	0.000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05899103	chr15:65394570	15	65394570	LOC390595	Island	-0.1705	0.0398	0.000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05156901	chr22:51016646	22	51016646	CPT1B;CHKB-CPT1B	Island	0.3207	0.0748	0.000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25451345	chr1:110709053	1	110709053	SLC6A17	Open sea	-0.0691	0.0161	0.000018	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09879253	chr17:45935359	17	45935359	-	Open sea	0.0933	0.0218	0.000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg26827202	chr2:196439116	2	196439116	-	Open sea	0.085	0.0199	0.000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10712211	chr8:70845033	8	70845033	-	Open sea	0.0873	0.0204	0.000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00805292	chr8:49816427	8	49816427	-	Open sea	0.1049	0.0246	0.000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18411015	chr4:55650446	4	55650446	-	Open sea	0.0766	0.0179	0.000019	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15934191	chr6:98298775	6	98298775	-	Open sea	0.1074	0.0252	0.00002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16365373	chr10:102898409	10	102898409	-	North shore	0.1259	0.0295	0.00002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07332757	chr16:88593924	16	88593924	ZFPM1	South shelf	-0.0955	0.0224	0.00002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09195771	chr10:4312482	10	4312482	-	Open sea	0.0653	0.0153	0.00002	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15942325	chr8:9268401	8	9268401	-	Open sea	0.1226	0.0288	0.000021	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19143959	chr15:40572794	15	40572794	-	North shore	-0.1231	0.029	0.000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23757461	chr18:55924888	18	55924888	NEDD4L	South shore	0.0633	0.0149	0.000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02285386	chr22:35695157	22	35695157	TOM1	North shore	-0.0321	0.0076	0.000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00960204	chr6:140802228	6	140802228	-	Open sea	0.0911	0.0215	0.000022	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15768040	chr9:98222052	9	98222052	PTCH1	Open sea	0.184	0.0434	0.000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21364696	chr1:36839798	1	36839798	STK40	Open sea	-0.0402	0.0095	0.000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09983920	chr10:98898179	10	98898179	SLIT1	Open sea	-0.11	0.026	0.000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27462685	chr13:75129579	13	75129579	LINC00347	Open sea	-0.1493	0.0353	0.000023	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13813008	chr9:98428936	9	98428936	-	Open sea	0.1514	0.0358	0.000024	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00718518	chr5:171766029	5	171766029	SH3PXD2B	North shore	-0.0792	0.0188	0.000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10333023	chr11:128774411	11	128774411	KCNJ5;C11orf45	Open sea	-0.1489	0.0353	0.000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00270625	chr22:51017019	22	51017019	CPT1B;CHKB-CPT1B	Island	0.2804	0.0666	0.000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10801420	chr3:9944591	3	9944591	IL17RE	Open sea	-0.1179	0.028	0.000025	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14025021	chr15:43809510	15	43809510	MAP1A	Open sea	0.0775	0.0184	0.000026	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg20258698	chr7:47556811	7	47556811	TNS3	Open sea	-0.1822	0.0435	0.000028	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12605353	chr8:55083464	8	55083464	-	Open sea	0.0873	0.0208	0.000028	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04543319	chr20:30435686	20	30435686	-	North shore	0.0831	0.0199	0.000029	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00621943	chr6:31646236	6	31646236	LY6G5C	North shelf	-0.0793	0.019	0.00003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10606725	chr21:42551825	21	42551825	PLAC4;BACE2	Open sea	-0.0524	0.0126	0.00003	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25247351	chr6:32908794	6	32908794	HLA-DMB	Open sea	0.0663	0.0159	0.000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00991639	chr8:110605574	8	110605574	SYBU	Open sea	0.0828	0.0199	0.000031	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01071534	chr21:46385572	21	46385572	C21orf70	North shore	-0.0385	0.0093	0.000032	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04638395	chr11:74892693	11	74892693	SLCO2B1	Open sea	0.0815	0.0197	0.000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13889950	chr3:177076825	3	177076825	-	Open sea	-0.0556	0.0134	0.000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10915554	chr9:73021673	9	73021673	KLF9	Open sea	0.1186	0.0286	0.000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg04868991	chr15:101514483	15	101514483	LRRK1	South shore	-0.178	0.043	0.000034	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07474825	chr19:10677826	19	10677826	KRI1;CDKN2D	North shore	-0.0513	0.0124	0.000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10060399	chr16:725168	16	725168	RHBDL1	Open sea	0.0656	0.0159	0.000036	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00017931	chr6:157932180	6	157932180	ZDHHC14	Open sea	-0.0918	0.0223	0.000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06261268	chr2:46689340	2	46689340	-	Open sea	0.0651	0.0158	0.000037	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg18468041	chr10:851101	10	851101	-	Island	-0.0757	0.0184	0.000039	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00927594	chr15:101514299	15	101514299	LRRK1	Island	-0.1592	0.0387	0.000039	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19112186	chr22:51016638	22	51016638	CPT1B;CHKB-CPT1B	Island	0.3211	0.0781	0.000039	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg01819568	chr4:55528138	4	55528138	KIT	South shelf	0.0993	0.0242	0.000041	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21644387	chr2:663024	2	663024	-	South shelf	-0.0636	0.0155	0.000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17952465	chr22:51016839	22	51016839	CPT1B;CHKB-CPT1B	Island	0.2116	0.0516	0.000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg07339118	chr6:169251967	6	169251967	-	Open sea	0.0453	0.0111	0.000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg16128973	chr15:42749836	15	42749836	ZNF106	Open sea	0.0929	0.0227	0.000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19025685	chr1:54638490	1	54638490	CYB5RL	Open sea	-0.0556	0.0136	0.000042	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg25565476	chr7:106270744	7	106270744	-	Open sea	0.0882	0.0216	0.000044	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12118986	chr19:39074494	19	39074494	RYR1	Open sea	-0.0985	0.0242	0.000045	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10619411	chr15:101514474	15	101514474	LRRK1	South shore	-0.1263	0.031	0.000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24363820	chr22:51016703	22	51016703	CPT1B;CHKB-CPT1B	Island	0.2716	0.0666	0.000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08960443	chr9:140066947	9	140066947	TMEM210	North shore	0.1349	0.0331	0.000046	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23865831	chr15:83980262	15	83980262	-	Open sea	0.0789	0.0194	0.000047	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13985132	chr15:65394414	15	65394414	LOC390595	Island	-0.182	0.0449	0.000049	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21999471	chr11:128555317	11	128555317	-	Open sea	0.2123	0.0524	0.00005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15249796	chr17:56744413	17	56744413	TEX14	Open sea	0.1409	0.0348	0.00005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06438724	chr15:49089383	15	49089383	CEP152	Open sea	-0.1336	0.0329	0.00005	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02745221	chr14:99858359	14	99858359	-	Open sea	-0.1195	0.0295	0.000051	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg10072328	chr15:95286906	15	95286906	-	Open sea	0.1111	0.0276	0.000056	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg23678254	chr14:55647471	14	55647471	DLGAP5	Open sea	-0.1495	0.0372	0.000058	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg21135948	chr21:34915592	21	34915592	GART;SON	Island	-0.0079	0.002	0.000058	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08827454	chr6:30922981	6	30922981	-	North shore	0.0607	0.0151	0.000059	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg27502912	chr22:51017001	22	51017001	CPT1B;CHKB-CPT1B	Island	0.2159	0.0538	0.00006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg09045689	chr2:31613833	2	31613833	XDH	Open sea	-0.0298	0.0074	0.00006	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg00092301	chr5:142600451	5	142600451	ARHGAP26	Open sea	0.1241	0.031	0.000061	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12500589	chr21:41838303	21	41838303	DSCAM	Open sea	-0.0523	0.0131	0.000062	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg05560127	chr11:128554774	11	128554774	-	Open sea	0.1696	0.0424	0.000064	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19442201	chr15:40572550	15	40572550	-	Island	-0.1773	0.0444	0.000065	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg17983064	chr5:131396357	5	131396357	IL3	Open sea	-0.1067	0.0268	0.000067	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg24691814	chr1:65673302	1	65673302	AK4	Open sea	0.0753	0.0189	0.000068	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02068596	chr6:14068147	6	14068147	-	Open sea	-0.1682	0.0423	0.000071	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08811332	chr21:43185385	21	43185385	RIPK4	North shore	-0.0845	0.0213	0.000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg13532822	chr17:74769273	17	74769273	MFSD11	Open sea	-0.042	0.0106	0.000073	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02436969	chr5:171822592	5	171822592	SH3PXD2B	Open sea	-0.0847	0.0214	0.000074	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14201617	chr2:47382452	2	47382452	C2orf61	Open sea	-0.0598	0.0151	0.000075	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg14526825	chr21:46646076	21	46646076	ADARB1	Open sea	-0.0521	0.0132	0.000078	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19979370	chr11:128772355	11	128772355	KCNJ5;C11orf45	Open sea	-0.104	0.0265	0.000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08260245	chr22:51016501	22	51016501	CPT1B;CHKB-CPT1B	Island	0.3056	0.0778	0.000085	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg15504041	chr10:127477259	10	127477259	UROS	Open sea	-0.0342	0.0087	0.000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg02252742	chr16:89786500	16	89786500	ZNF276;VPS9D1	North shore	0.0787	0.0201	0.000087	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg12659626	chr11:2234975	11	2234975	-	Open sea	0.0838	0.0214	0.000089	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg06530441	chr22:51016950	22	51016950	CPT1B;CHKB-CPT1B	Island	0.2457	0.0628	0.000092	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19125089	chr21:44280344	21	44280344	WDR4	Open sea	-0.0365	0.0093	0.000093	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg19085407	chr10:135164596	10	135164596	PRAP1	Open sea	0.0936	0.024	0.000095	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only
Muskens I	California Biobank Program	33547282	2021-02-05	Downs Syndrome	EFO_0001064	latino individuals only	Supplementary Table 2	DNA methylation	Downs Syndrome	sex, batch effects, cell composition (reference based), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	357	1	Infants	Both	Other	cg08441138	chr11:128555233	11	128555233	-	Open sea	0.1407	0.0361	0.000097	None	33547282_Muskens-I_downs_syndrome_latino_individuals_only