author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02988288	chr1:145440445	1	145440445	TXNIP;NBPF20;NBPF10	Open sea	-0.362740067	0.053667951	0.0000000000623	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06348038	chr1:207038460	1	207038460	IL20	Open sea	-0.319247046	0.054154954	0.00000000883	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06690548	chr4:139162808	4	139162808	SLC7A11	Open sea	-0.195339535	0.03436254	0.0000000288	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04861640	chr6:28234605	6	28234605	ZNF187	North shore	-0.221078552	0.040084408	0.0000000684	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19693031	chr1:145441552	1	145441552	TXNIP	Open sea	-0.194252543	0.035343837	0.0000000768	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23191724	chr11:70267556	11	70267556	CTTN	Open sea	-0.174624094	0.032119743	0.000000106	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25933692	chr15:40561855	15	40561855	PAK6	Open sea	0.125395954	0.023096749	0.000000119	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15460802	chr9:137352086	9	137352086	-	Open sea	0.119447671	0.02231702	0.000000178	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00858840	chr2:171573839	2	171573839	SP5	Island	-0.187275925	0.035450315	0.000000227	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04253876	chr2:30453758	2	30453758	LBH	Island	-0.127961911	0.024173561	0.000000233	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26974062	chr1:145440734	1	145440734	TXNIP;NBPF20;NBPF10	Open sea	-0.256363363	0.048941981	0.000000275	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10775792	chr1:161228455	1	161228455	PCP4L1	North shore	-0.147995196	0.028657649	0.000000424	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01562603	chr15:31657070	15	31657070	KLF13	Open sea	-0.115852487	0.022405568	0.000000437	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25249207	chr19:56125145	19	56125145	-	North shore	-0.092141311	0.017968839	0.000000589	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05261893	chr3:134798947	3	134798947	EPHB1	Open sea	-0.175614509	0.035054819	0.00000087	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08027385	chr7:45960865	7	45960865	IGFBP3	Island	-0.237210395	0.047671522	0.000000994	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12620322	chr10:77969251	10	77969251	C10orf11	Open sea	0.094641188	0.018906158	0.00000103	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01390039	chr16:89315293	16	89315293	-	Island	-0.165442614	0.033528565	0.00000125	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10096645	chr18:24130851	18	24130851	KCTD1	Island	-0.108776149	0.02203127	0.00000135	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23649290	chr14:68613343	14	68613343	RAD51B	Open sea	-0.121881035	0.024815667	0.00000148	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06367459	chr19:55898325	19	55898325	RPL28	South shore	-0.116830694	0.023894242	0.00000165	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14183647	chr1:28587132	1	28587132	SESN2	Island	-0.125383403	0.025765538	0.00000181	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00803207	chr8:133913826	8	133913826	TG	Open sea	-0.135641829	0.027904995	0.00000183	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09556043	chr4:144621952	4	144621952	FREM3	Island	-0.169531603	0.034981751	0.00000189	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04974899	chr20:25177027	20	25177027	ENTPD6	Island	-0.128101004	0.026501103	0.0000021	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17379926	chr1:174934845	1	174934845	RABGAP1L	Open sea	-0.17226992	0.035944775	0.00000242	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09727543	chr22:31644379	22	31644379	LIMK2	Open sea	-0.16918788	0.03529946	0.00000242	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23855107	chr1:17336286	1	17336286	ATP13A2	North shore	-0.093337141	0.019490483	0.00000281	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24986815	chr1:227128974	1	227128974	ADCK3	South shore	-0.067505367	0.014039061	0.00000305	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09443439	chr7:69126948	7	69126948	AUTS2	Open sea	0.105880629	0.022300882	0.00000325	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01891738	chr1:27961772	1	27961772	FGR	Island	-0.078120534	0.016409229	0.00000345	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10943359	chr4:165304531	4	165304531	MARCH1	Island	-0.120078804	0.025454038	0.00000362	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17431362	chr1:93590625	1	93590625	MTF2	Open sea	-0.081015154	0.017230086	0.0000044	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19929914	chr3:158457048	3	158457048	-	Open sea	-0.138769403	0.029790375	0.0000046	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10382620	chr16:73467352	16	73467352	-	Open sea	-0.080926177	0.017278972	0.00000477	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02646528	chr11:56949288	11	56949288	LRRC55	South shore	-0.086775355	0.018596657	0.000005	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20819424	chr3:105157177	3	105157177	ALCAM	Open sea	0.183142644	0.039591842	0.00000516	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05270693	chr11:121288120	11	121288120	-	Open sea	-0.169255431	0.03668763	0.00000549	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03139057	chr19:39989234	19	39989234	DLL3	North shore	-0.121024044	0.026241271	0.0000058	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14314268	chr7:158622895	7	158622895	ESYT2	South shore	-0.139413167	0.030278524	0.00000586	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05658487	chr5:1887583	5	1887583	-	Island	-0.107821118	0.023521751	0.00000673	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23720331	chr10:123873670	10	123873670	TACC2	South shore	-0.159272833	0.034862836	0.00000675	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17227726	chr10:133510829	10	133510829	-	South shelf	-0.327878111	0.071954022	0.00000683	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24522105	chr3:130465237	3	130465237	PIK3R4	North shore	0.174780354	0.038318027	0.00000691	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01555014	chr1:32827710	1	32827710	LOC100128071;TSSK3	Island	-0.141780153	0.031050064	0.00000692	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00455402	chr19:21769736	19	21769736	-	Island	-0.183008719	0.040201394	0.00000717	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02431672	chr1:43534324	1	43534324	-	Island	-0.111411638	0.024496796	0.00000782	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20443018	chr6:110796274	6	110796274	SLC22A16	North shore	-0.086665843	0.019033033	0.0000082	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09196572	chr6:13615041	6	13615041	SIRT5;NOL7	Island	-0.151699081	0.033536409	0.0000083	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23469025	chr20:2645106	20	2645106	IDH3B	South shore	-0.200025602	0.044315323	0.00000845	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25164589	chr10:63540024	10	63540024	-	Open sea	-0.164909841	0.036531175	0.00000856	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04144517	chrX:22392431	X	22392431	PTCHD1-AS	Open sea	-0.172069765	0.038144541	0.00000865	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01437571	chr19:33792148	19	33792148	CEBPA	Island	-0.127271013	0.028202644	0.00000891	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14202850	chr17:43974869	17	43974869	MAPT;LOC100130148	Island	-0.100288302	0.02219764	0.00000915	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14421700	chr17:77755965	17	77755965	CBX2	North shelf	-0.062089945	0.013629422	0.00000959	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00860590	chr7:150934650	7	150934650	CHPF2;MIR671	Island	0.084170219	0.01862423	0.0000096	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03335476	chr16:4381533	16	4381533	GLIS2	South shelf	-0.103573683	0.022999202	0.00000967	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20313677	chr1:3738610	1	3738610	KIAA0562	Open sea	-0.067979617	0.014982892	0.0000098	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14521508	chr17:80056159	17	80056159	FASN	Island	-0.145404365	0.03248165	0.0000102	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02837162	chr1:37090344	1	37090344	-	Open sea	0.105720849	0.023636788	0.000011	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08299223	chr5:1049840	5	1049840	-	North shelf	-0.186620174	0.041907471	0.0000111	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18229107	chr14:64854676	14	64854676	MTHFD1	Island	-0.193500461	0.043485532	0.0000112	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02176215	chr14:63767354	14	63767354	-	Open sea	-0.069528626	0.015444943	0.0000113	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26501313	chr19:35630425	19	35630425	FXYD1	North shore	-0.096351973	0.021559741	0.0000114	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10392188	chr10:11203213	10	11203213	CELF2	North shelf	-0.076097446	0.016971032	0.0000116	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18040878	chr12:54409229	12	54409229	HOXC4;HOXC6;HOXC5	South shore	-0.098982115	0.022214187	0.000012	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04679040	chr2:74726700	2	74726700	LBX2	Island	-0.226953472	0.051256142	0.0000122	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11865245	chr5:154210989	5	154210989	FAXDC2	Open sea	-0.069490104	0.015507897	0.0000123	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11260097	chr7:121940647	7	121940647	-	Island	-0.074533618	0.016682754	0.0000126	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14374754	chr9:96714295	9	96714295	BARX1	Island	-0.141809099	0.032032268	0.0000127	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22898647	chr7:70597440	7	70597440	WBSCR17	Island	-0.114278124	0.025774212	0.0000128	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16554331	chr4:7043330	4	7043330	CCDC96;LOC100129931	North shore	-0.068961551	0.015435034	0.000013	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21869174	chr1:3385687	1	3385687	ARHGEF16	Open sea	-0.075023944	0.016865626	0.0000136	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00928711	chr22:18350448	22	18350448	MICAL3	Open sea	-0.121017533	0.027417018	0.0000138	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05009601	chr7:121944500	7	121944500	FEZF1	Island	-0.100888607	0.022835829	0.0000141	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13037201	chr14:89018372	14	89018372	PTPN21	South shore	-0.257990734	0.058807135	0.0000145	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15520606	chr17:33288579	17	33288579	ZNF830;CCT6B	Island	0.089585665	0.020301668	0.0000148	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17341118	chr6:32041834	6	32041834	TNXB	Open sea	-0.106668244	0.024237257	0.0000149	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15404275	chr2:47316338	2	47316338	C2orf61	Open sea	-0.073908042	0.016718919	0.0000154	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05870398	chr4:4670703	4	4670703	-	Open sea	0.095000767	0.021602357	0.0000156	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07269313	chr4:143043281	4	143043281	INPP4B	Open sea	-0.127787406	0.029166861	0.0000157	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25486757	chr3:73674074	3	73674074	PDZRN3	Island	-0.098456636	0.022424246	0.0000159	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05711131	chr19:36231948	19	36231948	TMEM149	Island	-0.136637482	0.031240295	0.0000161	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08667963	chr6:5367823	6	5367823	FARS2	Open sea	-0.228313721	0.052313425	0.0000161	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15381098	chr15:83378639	15	83378639	AP3B2	Island	-0.162309178	0.037207342	0.0000166	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05848785	chr10:73480942	10	73480942	C10orf105;CDH23	Open sea	0.093199923	0.021269252	0.0000167	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23702412	chr14:70655803	14	70655803	SLC8A3	Island	-0.127448981	0.029216996	0.0000171	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22936497	chr12:34276619	12	34276619	-	Open sea	-0.072968677	0.016598023	0.0000171	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24611427	chr4:140099304	4	140099304	-	Island	-0.147350996	0.033821459	0.0000172	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00413617	chr11:17757415	11	17757415	KCNC1	Island	-0.142268542	0.032652591	0.0000172	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00462271	chr2:65621498	2	65621498	SPRED2	Open sea	0.101112881	0.023157028	0.0000175	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01497368	chr4:15931311	4	15931311	-	Open sea	0.115499205	0.026495418	0.0000176	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23619431	chr17:74536068	17	74536068	PRCD	South shore	0.078761454	0.01798079	0.0000178	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13644182	chr19:12747889	19	12747889	-	North shelf	-0.075242104	0.017165066	0.0000178	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18688704	chr4:157889520	4	157889520	PDGFC	North shelf	-0.107242467	0.02462334	0.0000181	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19930288	chr4:184021302	4	184021302	WWC2;C4orf38	Island	-0.108219865	0.024906446	0.0000189	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07967641	chr12:26441031	12	26441031	-	Open sea	-0.075957429	0.01738993	0.000019	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04800534	chr1:47532601	1	47532601	CYP4Z1	Open sea	-0.082847964	0.019008963	0.0000191	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16522491	chr14:105310639	14	105310639	-	South shore	-0.067445124	0.015421097	0.0000195	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13459416	chr5:115815799	5	115815799	SEMA6A	Open sea	0.11805696	0.027298138	0.0000203	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05605194	chr2:7739870	2	7739870	-	Open sea	-0.091196593	0.02102962	0.0000204	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24764310	chr7:157512201	7	157512201	PTPRN2	Open sea	-0.129097497	0.029886084	0.0000205	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06512849	chr5:112631052	5	112631052	MCC	South shore	-0.113512574	0.02628063	0.0000209	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03353926	chr2:45165527	2	45165527	-	Island	-0.094652118	0.021873112	0.000021	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21690805	chr22:50631268	22	50631268	TRABD	North shore	-0.19267095	0.044762273	0.000021	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16749578	chr19:17357619	19	17357619	NR2F6	South shore	-0.133476553	0.030975575	0.0000213	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23748737	chr22:20791733	22	20791733	SCARF2	Island	-0.092416715	0.021368696	0.0000213	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14428391	chr2:217442832	2	217442832	-	Open sea	-0.063822596	0.014646787	0.0000215	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22679706	chr11:122543635	11	122543635	UBASH3B	Open sea	0.079942845	0.018457295	0.0000217	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02391450	chr5:171969338	5	171969338	-	Open sea	0.114854121	0.026661723	0.0000219	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06088069	chr14:75895604	14	75895604	JDP2	South shore	-0.054951803	0.012574851	0.0000224	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09219877	chr16:2287294	16	2287294	DNASE1L2	Island	-0.108967446	0.025324727	0.0000226	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13190003	chr1:173193738	1	173193738	-	Open sea	-0.070009959	0.016163933	0.0000228	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19081868	chr2:113991662	2	113991662	PAX8-AS1;PAX8	North shore	0.076389564	0.017671079	0.0000228	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03835061	chr5:134364583	5	134364583	PITX1	Island	-0.123556397	0.028783616	0.0000231	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21310090	chr20:44538669	20	44538669	PLTP	North shore	-0.059998625	0.01380805	0.0000234	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06671450	chr9:36985987	9	36985987	PAX5	Island	-0.090077865	0.020931351	0.0000235	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12020476	chr7:100183423	7	100183423	LRCH4;FBXO24	North shore	0.418117505	0.097899008	0.0000237	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09542692	chr10:37422993	10	37422993	ANKRD30A	Open sea	-0.130210556	0.030438675	0.0000244	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13318528	chr1:217860936	1	217860936	SPATA17	Open sea	-0.107419966	0.025075777	0.0000245	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13045813	chr2:196933518	2	196933518	DNAH7	Island	0.097230803	0.022705066	0.0000252	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01352586	chr1:202995473	1	202995473	-	Island	-0.138343934	0.032417382	0.0000253	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23434468	chr6:109245348	6	109245348	ARMC2-AS1;ARMC2	Open sea	-0.129475303	0.030335778	0.0000254	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16349876	chr19:50554013	19	50554013	FLJ26850	Island	-0.132307793	0.031008816	0.0000255	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06925217	chr16:2962609	16	2962609	FLYWCH1	South shore	-0.141651941	0.03321206	0.0000255	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02736420	chr13:95364569	13	95364569	SOX21	Island	-0.157527289	0.036971265	0.0000257	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01072045	chr11:47475796	11	47475796	-	Open sea	-0.097569869	0.022812708	0.0000257	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22563672	chr14:105856393	14	105856393	PACS2	Open sea	-0.068631817	0.015964008	0.0000263	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21395519	chr3:122746985	3	122746985	SEMA5B	Island	-0.124638374	0.02925745	0.0000264	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10671478	chr20:52790299	20	52790299	CYP24A1	Island	-0.251771365	0.05927118	0.0000264	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10521638	chr4:74734919	4	74734919	CXCL1	Island	-0.147760793	0.034731176	0.0000265	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19729279	chr5:133861951	5	133861951	PHF15	Island	-0.126168146	0.029631184	0.0000266	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16882851	chr7:1798422	7	1798422	-	Open sea	-0.111959878	0.026288951	0.000027	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25156915	chr4:174427388	4	174427388	-	North shore	-0.085322618	0.019993762	0.0000277	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07690547	chr13:108919095	13	108919095	-	Open sea	-0.13647355	0.032179126	0.0000283	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02897230	chr4:174429541	4	174429541	-	North shore	-0.141017342	0.033266019	0.0000284	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26827893	chr20:21105829	20	21105829	PLK1S1	North shore	-0.116698119	0.027491311	0.0000284	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11853830	chr5:92914036	5	92914036	FLJ42709	North shore	-0.097532161	0.022939585	0.0000286	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17619116	chr16:75354212	16	75354212	CFDP1	Open sea	-0.260485065	0.061617625	0.0000288	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22851252	chr1:161136106	1	161136106	PPOX	Island	-0.127429963	0.030073869	0.000029	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16828491	chr4:8230829	4	8230829	SH3TC1	Open sea	-0.076109457	0.017848683	0.0000291	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22512888	chr1:1178191	1	1178191	FAM132A	Island	0.087703245	0.020667277	0.0000303	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15452097	chr12:77598141	12	77598141	-	Open sea	-0.185829795	0.044064908	0.0000305	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06418113	chr18:43915901	18	43915901	RNF165	South shore	-0.086238639	0.020342809	0.000031	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01148478	chr4:174255089	4	174255089	HMGB2	Island	0.06158655	0.014428031	0.0000314	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09635667	chr17:2300514	17	2300514	MNT	North shelf	-0.064126274	0.015048413	0.0000316	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01262836	chr11:131560477	11	131560477	NTM	Island	-0.09057079	0.021413569	0.0000318	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25876906	chr7:73702862	7	73702862	CLIP2	North shore	-0.102972015	0.024381958	0.0000318	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16837973	chr17:5138634	17	5138634	C17orf87	Open sea	-0.053218238	0.012422962	0.0000323	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17286491	chr1:179923514	1	179923514	CEP350	North shore	-0.150702605	0.03583218	0.0000325	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21207593	chr17:33310495	17	33310495	LIG3	South shelf	-0.132747384	0.031543361	0.0000325	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23965861	chr5:10705332	5	10705332	DAP	Open sea	-0.098838722	0.02343429	0.0000328	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20779757	chr15:90358527	15	90358527	ANPEP	Island	-0.150958813	0.03592063	0.0000329	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19787727	chr14:57264070	14	57264070	-	North shore	-0.095658167	0.022678869	0.000033	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15241103	chr17:4446791	17	4446791	MYBBP1A	Open sea	0.098115871	0.023294114	0.0000336	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16776421	chr16:541243	16	541243	RAB11FIP3	Open sea	0.070811505	0.016733514	0.0000341	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03004985	chr3:46735695	3	46735695	ALS2CL	Island	-0.069676647	0.016468667	0.0000345	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08878713	chr1:31325813	1	31325813	-	Open sea	0.072520165	0.017163144	0.0000347	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07569216	chr15:53075533	15	53075533	ONECUT1	North shore	-0.185721359	0.044373761	0.0000348	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24473633	chr8:142138319	8	142138319	DENND3	Island	-0.132349749	0.03157319	0.0000349	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19375710	chr1:26105045	1	26105045	MAN1C1	Open sea	0.088993317	0.02115003	0.000035	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21266798	chr13:110433636	13	110433636	IRS2	North shore	0.079935158	0.018978657	0.0000354	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07072366	chr8:19798005	8	19798005	LPL	Island	-0.088232145	0.020990622	0.0000357	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11384744	chr7:16794623	7	16794623	TSPAN13	South shore	-0.088842905	0.021149959	0.000036	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18245735	chr2:220443780	2	220443780	-	Open sea	-0.058620961	0.013828505	0.0000363	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26107890	chr3:124860686	3	124860686	SLC12A8	Island	0.078957884	0.018775185	0.0000365	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19842809	chr14:37125997	14	37125997	PAX9	North shore	-0.127761624	0.030552864	0.0000365	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14423417	chr22:46263018	22	46263018	-	Island	-0.122198278	0.029217233	0.0000366	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03404427	chr11:72325426	11	72325426	PDE2A	Open sea	-0.105842515	0.025290966	0.000037	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18693985	chr5:173351052	5	173351052	CPEB4	Open sea	0.468024936	0.11240049	0.0000372	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01947415	chr7:913107	7	913107	UNC84A	North shelf	-0.119767031	0.028677308	0.0000376	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26862622	chr21:43860746	21	43860746	UBASH3A	Open sea	0.090312041	0.021570899	0.000038	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05367248	chr10:13203479	10	13203479	MCM10	Island	-0.142927645	0.034305478	0.0000385	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13131483	chr19:21769877	19	21769877	-	South shore	-0.180422144	0.043350451	0.0000385	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23570785	chr7:102576079	7	102576079	LRRC17;FBXL13	Open sea	-0.121063971	0.029041053	0.0000388	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02482699	chr11:1404145	11	1404145	-	North shore	-0.139395512	0.033485763	0.0000391	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05844788	chr3:10336053	3	10336053	GHRL	Open sea	-0.076244478	0.018194409	0.0000392	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23563958	chr18:43407719	18	43407719	SIGLEC15	Open sea	-0.082500694	0.019718645	0.0000393	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23857313	chr14:100842188	14	100842188	WARS;WDR25	North shore	-0.206704131	0.049759139	0.0000395	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10099813	chr4:15022372	4	15022372	CPEB2	Open sea	-0.087641582	0.020974057	0.0000396	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11275039	chr10:129824584	10	129824584	PTPRE	Open sea	0.085598176	0.020478125	0.0000396	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26093175	chr3:66024549	3	66024549	MAGI1	Island	-0.10435361	0.02503716	0.0000398	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19774450	chrX:23721943	X	23721943	ACOT9	Open sea	-0.123381533	0.029647656	0.0000399	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00824087	chr17:48058055	17	48058055	-	Open sea	0.078489783	0.018765519	0.0000401	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04481478	chr2:179567366	2	179567366	TTN	Open sea	-0.327638093	0.079009417	0.0000401	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14624881	chr12:48403924	12	48403924	-	Open sea	0.077245875	0.018467809	0.0000403	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06722633	chr1:37499309	1	37499309	GRIK3	Island	-0.095124336	0.022824816	0.0000406	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.157998698	0.038068085	0.0000407	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23704097	chr15:98721461	15	98721461	-	Open sea	-0.156063897	0.037602567	0.0000408	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16171534	chr3:49203975	3	49203975	CCDC71	South shore	0.119875804	0.028857888	0.0000413	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26095194	chr5:172197489	5	172197489	DUSP1	Island	-0.097149703	0.023345064	0.0000414	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23243888	chrX:140820504	X	140820504	-	Open sea	-0.186089993	0.044946435	0.000042	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18159860	chr5:72678420	5	72678420	-	Island	-0.095544877	0.022977934	0.0000422	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24779605	chr4:53617686	4	53617686	ERVMER34-1	South shore	-0.090663223	0.021789839	0.0000422	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25433624	chr20:37435119	20	37435119	PPP1R16B	Island	0.093578381	0.022514049	0.0000426	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16026561	chr20:35917328	20	35917328	MANBAL	North shore	-0.071733464	0.017178504	0.0000426	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07788348	chr7:122527472	7	122527472	CADPS2	South shore	-0.095332557	0.02294588	0.0000428	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07665508	chr14:23010822	14	23010822	-	Open sea	0.076697714	0.018405259	0.0000431	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03589296	chr2:66666292	2	66666292	MEIS1	South shelf	-0.090329811	0.021747747	0.0000435	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18788945	chr19:17378096	19	17378096	C19orf62	Open sea	-0.12403501	0.029975188	0.0000439	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11313061	chr20:50877236	20	50877236	-	Open sea	0.113444703	0.027404262	0.0000441	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03513246	chr18:30351342	18	30351342	KLHL14	Island	-0.111952283	0.027045416	0.0000442	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04756051	chr6:160908522	6	160908522	LPAL2	Open sea	-0.094643828	0.022864446	0.0000456	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08871101	chr2:45182340	2	45182340	-	Island	-0.114082734	0.027622296	0.0000458	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21254939	chr4:7657303	4	7657303	SORCS2	Open sea	-0.087520404	0.021126913	0.0000458	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02682092	chr11:124647347	11	124647347	MSANTD2	Open sea	-0.120501442	0.02918963	0.0000458	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02286715	chr4:6473881	4	6473881	PPP2R2C	Island	-0.14725856	0.035725252	0.000046	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19215181	chr8:1693221	8	1693221	-	Open sea	-0.075828172	0.018279878	0.0000466	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20353857	chr5:131347831	5	131347831	ACSL6	South shore	-0.085127811	0.020569446	0.0000469	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13484753	chr14:99393263	14	99393263	-	Open sea	-0.091613312	0.022167756	0.0000472	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09417682	chr20:44986386	20	44986386	SLC35C2	Open sea	-0.05454253	0.013042874	0.0000475	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17610068	chr17:77458514	17	77458514	RBFOX3	North shore	-0.296683494	0.072312765	0.0000482	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00247557	chr18:5197071	18	5197071	LOC642597	Island	-0.100289059	0.024328015	0.0000483	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17252095	chr5:124201716	5	124201716	-	Open sea	-0.091180991	0.022092676	0.0000483	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03630413	chr15:96866537	15	96866537	-	Island	-0.129515259	0.031492225	0.0000484	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27467249	chr20:43159618	20	43159618	PKIG	North shore	-0.076123776	0.018399773	0.0000487	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19479609	chr2:208390216	2	208390216	-	North shelf	-0.117601024	0.028589598	0.0000489	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08794574	chr14:103292047	14	103292047	TRAF3	Open sea	0.100907302	0.024498861	0.0000489	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14655843	chr9:114688737	9	114688737	UGCG	Open sea	-0.079485378	0.019240869	0.0000492	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01558909	chr16:215845	16	215845	HBM	Island	0.058250476	0.013991858	0.0000492	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17782495	chr2:163466280	2	163466280	KCNH7	Open sea	-0.14790551	0.036034583	0.0000494	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23972298	chr1:32665582	1	32665582	CCDC28B	North shore	0.082230656	0.019928516	0.0000497	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18952546	chr6:158138081	6	158138081	-	Open sea	0.088742896	0.021545266	0.0000502	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00126365	chr14:81893759	14	81893759	STON2	Open sea	-0.083554311	0.020276136	0.0000506	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18242131	chr11:16626109	11	16626109	-	Island	-0.159256034	0.038902552	0.0000514	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21658670	chr19:41930894	19	41930894	BCKDHA	Open sea	-0.057850207	0.013930487	0.0000514	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09793632	chr10:81456550	10	81456550	-	North shelf	-0.088588198	0.021540812	0.0000516	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23473819	chr19:708670	19	708670	PALM	Island	-0.1663286	0.04065581	0.0000518	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08882541	chr3:141005905	3	141005905	PXYLP1	Open sea	0.092820946	0.022596458	0.000052	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17015051	chr4:139881640	4	139881640	-	Open sea	0.088372066	0.021501556	0.0000521	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06154883	chr14:64750791	14	64750791	ESR2;MIR548AZ	Open sea	-0.062748129	0.015162729	0.0000522	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08651517	chr1:110888403	1	110888403	RBM15	Open sea	0.070022422	0.016969864	0.0000523	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08156531	chr17:42993050	17	42993050	GFAP	South shelf	0.074992395	0.018218226	0.0000532	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13326926	chr12:48153388	12	48153388	RAPGEF3	Island	0.103846603	0.025363873	0.0000538	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06511678	chr18:7038746	18	7038746	LAMA1	Open sea	-0.131346259	0.03214414	0.0000539	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24504307	chr6:134963096	6	134963096	-	Open sea	-0.06847416	0.016648807	0.0000557	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25215340	chr11:2907127	11	2907127	CDKN1C	North shore	-0.129441657	0.031742427	0.0000558	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22362878	chr3:38647824	3	38647824	SCN5A	Open sea	0.074431156	0.01813976	0.0000562	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18483289	chr20:644897	20	644897	SCRT2	Island	-0.085282275	0.020837606	0.0000564	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21417735	chr1:52004899	1	52004899	-	Open sea	0.098384588	0.024109837	0.0000574	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23864367	chr1:110415366	1	110415366	-	Open sea	0.064438643	0.015672726	0.0000574	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01797257	chr1:18969652	1	18969652	PAX7	Island	-0.119481673	0.029340466	0.0000576	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00822078	chr16:51805391	16	51805391	LINC01571	Open sea	-0.166873153	0.041067336	0.000058	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19339668	chr9:14348002	9	14348002	NFIB	Island	-0.106403728	0.026112576	0.000058	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09614653	chr10:22542145	10	22542145	-	Island	-0.138318887	0.034023399	0.0000583	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20959866	chr1:4714008	1	4714008	AJAP1	Island	-0.112996793	0.027823308	0.0000607	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15767067	chr5:167394988	5	167394988	TENM2	Open sea	-0.122974128	0.030308129	0.000061	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03161190	chr10:104535792	10	104535792	C10orf26	Open sea	-0.132949406	0.032799683	0.0000615	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11769062	chr1:2162893	1	2162893	SKI	South shore	-0.130271429	0.032151376	0.000062	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17754171	chr2:200324668	2	200324668	SATB2	Island	0.058045579	0.014150107	0.0000625	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01622872	chr11:74975244	11	74975244	ARRB1	Open sea	-0.129034295	0.031865248	0.0000627	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26472074	chr12:25057098	12	25057098	BCAT1	South shore	-0.095466262	0.023515379	0.0000628	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18641486	chr14:37641660	14	37641660	SLC25A21;LOC100129794	Island	-0.149218909	0.036888918	0.0000629	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00528492	chr6:32408863	6	32408863	HLA-DRA	Open sea	-0.142185592	0.035147829	0.0000631	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22667851	chr16:11405878	16	11405878	-	Open sea	0.095321804	0.023491274	0.0000633	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15884789	chr6:28047400	6	28047400	ZNF165	Open sea	-0.076175093	0.018711807	0.0000634	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01821854	chr4:154711347	4	154711347	SFRP2	North shore	-0.075750017	0.018609108	0.0000636	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16990009	chr6:30880155	6	30880155	GTF2H4	North shore	-0.271052492	0.06716805	0.0000637	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17845732	chr19:36130321	19	36130321	-	South shore	0.121474597	0.030019754	0.0000638	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01785568	chr4:4864833	4	4864833	MSX1	Island	-0.116294471	0.028738203	0.0000641	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12783132	chr12:54943700	12	54943700	PDE1B	Open sea	-0.113224802	0.027978337	0.0000643	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25666919	chr7:102074615	7	102074615	ORAI2	South shore	-0.130194605	0.032213742	0.0000646	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05652225	chr17:37295709	17	37295709	PLXDC1	Open sea	0.085127221	0.020987712	0.0000653	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12215340	chr20:4229610	20	4229610	ADRA1D	Island	-0.196355721	0.04871938	0.0000657	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13672637	chr17:39701003	17	39701003	-	Open sea	0.100926084	0.024959315	0.0000663	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	ch.5.2558853F	chr5:138115063	5	138115063	CTNNA1	Open sea	-0.178028767	0.044206911	0.0000669	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg07170231	chr20:5590750	20	5590750	RP5-1022P6.2	North shore	-0.1352906	0.033564869	0.0000672	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg21182407	chr6:3119541	6	3119541	BPHL	South shore	-0.07705323	0.019001903	0.0000673	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20132581	chr12:125233163	12	125233163	-	Open sea	-0.094844573	0.023462938	0.0000674	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05447186	chr20:3869454	20	3869454	PANK2	Island	-0.103452119	0.025619126	0.0000675	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15775200	chr2:242977420	2	242977420	-	Open sea	-0.095677617	0.023704144	0.0000689	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19560758	chr1:8086721	1	8086721	ERRFI1	Island	-0.07558889	0.018669831	0.0000694	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03655237	chr22:25871954	22	25871954	-	Open sea	-0.1683253	0.041902768	0.0000699	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12543545	chr6:139975635	6	139975635	-	Open sea	-0.054936015	0.013466533	0.0000703	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00079536	chr11:119551071	11	119551071	PVRL1	Open sea	0.095744405	0.023761282	0.0000708	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27523577	chr22:50630587	22	50630587	TRABD	South shore	-0.099979232	0.024827091	0.0000709	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00876449	chr19:19844278	19	19844278	ZNF14	South shore	-0.134181043	0.033405295	0.0000712	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19169619	chr1:150459535	1	150459535	TARS2	Open sea	-0.159285072	0.039711021	0.0000718	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg09601175	chr2:177025608	2	177025608	-	Island	-0.087192586	0.021663554	0.0000735	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13604047	chr22:23046400	22	23046400	-	Open sea	0.249464368	0.062358305	0.0000735	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19572574	chr10:63592731	10	63592731	-	Open sea	-0.084158817	0.020905364	0.0000738	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26157475	chr17:43044987	17	43044987	C1QL1	Island	-0.093842597	0.023356691	0.0000744	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10343742	chr3:137483506	3	137483506	SOX14	Island	-0.059448737	0.014667251	0.0000747	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24345725	chr2:139205665	2	139205665	-	Open sea	-0.380754559	0.095341836	0.000075	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12586150	chr6:2840792	6	2840792	SERPINB1	North shore	-0.062850888	0.015536298	0.0000751	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27009703	chr7:27204894	7	27204894	HOXA9	Island	-0.16511889	0.041291208	0.0000753	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00540828	chr7:101546993	7	101546993	CUX1	Open sea	-0.277042184	0.069384542	0.0000756	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22720041	chr19:44952725	19	44952725	ZNF229	Island	-0.174102979	0.043567312	0.0000759	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13491481	chr3:62861142	3	62861142	CADPS	Island	-0.092224421	0.022980301	0.0000761	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08858091	chr17:27173437	17	27173437	-	South shelf	-0.121053972	0.030243035	0.0000761	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20766179	chr3:134361914	3	134361914	KY	Open sea	0.062810463	0.015546856	0.0000767	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14228177	chr7:1606526	7	1606526	-	North shelf	-0.055563221	0.01370636	0.0000771	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01899318	chr16:71523395	16	71523395	ZNF19	Open sea	0.128102766	0.032048936	0.0000774	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03836181	chr7:139733574	7	139733574	PARP12	Open sea	-0.072013006	0.017892787	0.0000774	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05931265	chr11:122527736	11	122527736	UBASH3B	South shore	-0.163199597	0.040891658	0.0000777	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12195135	chr19:58919312	19	58919312	ZNF584	North shore	-0.090183874	0.022495676	0.0000777	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24771840	chr18:47717446	18	47717446	MYO5B	North shelf	0.150212201	0.037621645	0.0000777	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12601142	chr12:495079	12	495079	KDM5A	North shelf	-0.115037609	0.028770852	0.0000779	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06585690	chr4:71262957	4	71262957	PROL1	Open sea	-0.13104739	0.032809934	0.0000781	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16007719	chr10:125929899	10	125929899	-	Open sea	0.100579147	0.025127345	0.0000781	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10318066	chr2:74045551	2	74045551	-	Open sea	-0.065534105	0.016271743	0.0000791	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13916298	chr3:108896099	3	108896099	C3orf66	Open sea	-0.073972582	0.018419923	0.0000794	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13792025	chr7:66205470	7	66205470	RABGEF1	Island	0.099985298	0.025004765	0.0000794	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg17082640	chr8:57205380	8	57205380	-	Open sea	0.170676169	0.042831316	0.0000795	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06063840	chr8:67345767	8	67345767	ADHFE1	South shore	-0.110008204	0.027546747	0.0000799	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06684321	chr11:66325466	11	66325466	ACTN3	North shore	0.110904856	0.027776285	0.00008	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25712085	chr22:45325789	22	45325789	PHF21B	Open sea	0.067507618	0.016786396	0.0000801	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10377216	chr3:186464087	3	186464087	-	Open sea	-0.080751654	0.020151379	0.0000802	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01210965	chr3:126259452	3	126259452	CHST13;C3orf22	North shore	-0.08559335	0.021379101	0.0000803	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24899545	chr6:7112846	6	7112846	RREB1	South shelf	-0.099047115	0.024791802	0.0000807	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg06650483	chr2:62954600	2	62954600	EHBP1	Open sea	-0.110119165	0.027592836	0.0000807	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23013854	chr3:122347635	3	122347635	PARP15	Open sea	-0.109503517	0.027436724	0.0000807	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03295107	chr7:151236292	7	151236292	-	Open sea	0.061124968	0.015172209	0.000081	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05147763	chr4:2078818	4	2078818	POLN	Open sea	0.055039879	0.013617105	0.0000811	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27127814	chr13:53425257	13	53425257	-	Island	-0.116304373	0.029168883	0.0000813	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25693439	chr16:4104417	16	4104417	ADCY9	Open sea	-0.070958265	0.017680473	0.0000813	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg14305801	chr9:126775546	9	126775546	LHX2	Island	-0.084287817	0.021070033	0.0000816	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00983122	chr8:139272559	8	139272559	FAM135B	Open sea	0.150810786	0.037913311	0.0000824	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19761358	chr2:239981932	2	239981932	HDAC4	Open sea	0.072855879	0.018179084	0.0000824	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27236629	chr15:96877720	15	96877720	NR2F2	Island	-0.106387577	0.02668701	0.0000826	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16901840	chr15:78913481	15	78913481	CHRNA3	Island	-0.096053347	0.024076367	0.0000829	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18846954	chr12:133028690	12	133028690	-	Open sea	0.061508799	0.015304421	0.0000839	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01942127	chr3:53529259	3	53529259	CACNA1D	Island	-0.096827323	0.024295258	0.0000841	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19010054	chr19:51416010	19	51416010	-	Island	-0.139322293	0.035061234	0.0000843	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04199574	chr19:14953527	19	14953527	OR7A10	Open sea	-0.06963043	0.017387423	0.0000846	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg15852700	chr16:30772531	16	30772531	RNF40;C16orf93	Island	-0.116981399	0.029416915	0.0000848	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22562942	chr8:24772309	8	24772309	NEFM	Island	-0.257992299	0.065116695	0.0000857	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12018098	chr19:38885481	19	38885481	SPRED3	Island	-0.130714682	0.032920286	0.0000858	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg16666329	chr5:76932526	5	76932526	OTP	Island	-0.080519179	0.020193628	0.0000868	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12829747	chr5:152836144	5	152836144	-	Open sea	-0.100496888	0.025276942	0.0000869	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23016257	chr7:31377934	7	31377934	NEUROD6	South shore	-0.102590157	0.025816931	0.0000873	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23762465	chr22:50360628	22	50360628	-	South shelf	-0.058230412	0.014502988	0.0000873	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg08597743	chrX:136646204	X	136646204	-	North shore	-0.151735062	0.038293018	0.0000876	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg03696393	chr13:107027491	13	107027491	-	Open sea	-0.070876764	0.017746046	0.0000877	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05560579	chr1:204982140	1	204982140	NFASC	Open sea	0.061857943	0.015437416	0.0000877	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02424926	chr1:16106241	1	16106241	FBLIM1	Open sea	0.059107811	0.014734392	0.0000879	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg04950301	chr6:12750392	6	12750392	PHACTR1	Island	-0.091797433	0.023090506	0.0000883	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20643936	chr8:145065325	8	145065325	GRINA	Island	-0.066108513	0.016540376	0.0000889	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20856413	chr11:16760217	11	16760217	C11orf58	Island	0.071932765	0.018033001	0.000089	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg12369353	chr13:36728963	13	36728963	-	Island	-0.180543183	0.045641406	0.0000891	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg26914373	chr20:39995782	20	39995782	EMILIN3	Island	-0.072618976	0.018210839	0.0000892	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg24848467	chr6:28134517	6	28134517	ZNF389	Open sea	-0.120735218	0.030490487	0.0000903	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg01861031	chr19:17326121	19	17326121	USE1	Island	0.050248379	0.012476065	0.0000903	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg05410915	chr11:981891	11	981891	AP2A2	South shore	-0.059710685	0.014915759	0.0000904	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22204045	chr10:27168776	10	27168776	-	Open sea	-0.078946523	0.019846169	0.0000905	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg27107970	chr17:79520734	17	79520734	C17orf70	South shore	-0.104584044	0.026445355	0.0000938	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00158789	chr17:59534683	17	59534683	TBX4	Island	-0.078406137	0.019767995	0.0000949	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg11115825	chr12:131295006	12	131295006	STX2	Open sea	0.091187541	0.0230553	0.0000958	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg19797308	chr12:123636175	12	123636175	-	Island	-0.130282846	0.033045764	0.000096	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg13427748	chr15:70767649	15	70767649	-	Open sea	-0.111390332	0.028223722	0.000096	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg23668445	chr4:815269	4	815269	CPLX1	North shelf	0.081607138	0.020609541	0.0000964	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg18303242	chr17:25879250	17	25879250	KSR1	Open sea	0.085811943	0.021688415	0.0000965	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10670616	chr8:67874674	8	67874674	TCF24	Island	-0.082647996	0.020877535	0.0000965	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg25143070	chr1:65432346	1	65432346	JAK1	Island	0.095253192	0.02411242	0.0000969	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg10184289	chr2:64870490	2	64870490	SERTAD2	Open sea	-0.124070551	0.031479285	0.0000969	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22110267	chr11:75052065	11	75052065	ARRB1	Open sea	-0.103439919	0.026228374	0.0000981	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg20055426	chr12:127211421	12	127211421	-	Island	-0.189562042	0.048229282	0.0000982	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg22164236	chr20:17881770	20	17881770	-	Open sea	-0.094491032	0.023948502	0.0000989	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg02688348	chr11:57103429	11	57103429	SSRP1	Island	-0.127844212	0.032492887	0.0000992	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)