author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00081799	chr1:6390793	1	6390793	ACOT7	Open sea	-0.001	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0068	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.012	0.00098	0	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0013	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06834177	chr1:6333843	1	6333843	ACOT7	Open sea	-0.00097	0.0001	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08679807	chr1:6338594	1	6338594	ACOT7	North shore	-0.0017	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0039	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0045	0.0002	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	0.018	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11346669	chr1:6342159	1	6342159	ACOT7	South shore	-0.0022	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11714702	chr1:6362473	1	6362473	ACOT7	Open sea	-0.00028	0.000034	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0025	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0053	0.00036	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.026	0.0023	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049283	chr1:6419606	1	6419606	ACOT7	Open sea	-0.0077	0.00026	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049283	chr1:6419606	1	6419606	ACOT7	Open sea	0.025	0.0016	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0026	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.0025	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0063	0.00029	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.029	0.0019	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18222440	chr1:6366658	1	6366658	ACOT7	Open sea	-0.001	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	-0.0084	0.001	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.015	0.0018	0	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.012	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	-0.0048	0.0003	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0058	0.00031	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.002	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26570804	chr1:6352357	1	6352357	ACOT7	Open sea	-0.00047	0.00005	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	0.43661	0.00511	2.5e-155	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16429975	chr1:6445632	1	6445632	ACOT7	Open sea	0.65583	0.00779	4.7e-154	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16170708	chr1:6390830	1	6390830	ACOT7	Open sea	0.49628	0.00626	2.9999999999999997e-149	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10770046	chr1:6446787	1	6446787	ACOT7	Open sea	0.54579	0.00699	5.1999999999999995e-148	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.33675	0.00445	2.2e-145	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.61806	0.00825	1.2e-144	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00081799	chr1:6390793	1	6390793	ACOT7	Open sea	0.49617	0.0067	1.2e-143	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18167466	chr1:6390473	1	6390473	ACOT7	Open sea	0.48138	0.0067	3.3e-141	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25706257	chr1:6390530	1	6390530	ACOT7	Open sea	0.57335	0.00813	9.2e-140	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00425213	chr1:6446095	1	6446095	ACOT7	Open sea	0.59374	0.00848	3.5e-139	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	0.46849	0.00676	2.5e-138	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04309375	chr1:6363886	1	6363886	ACOT7	Open sea	0.28077	0.00408	1.2e-137	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.50903	0.00746	4.4e-137	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	0.36588	0.00569	2.7e-132	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20630887	chr1:6417823	1	6417823	ACOT7	Open sea	0.28271	0.00452	3.9999999999999995e-130	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00777636	chr1:6446216	1	6446216	ACOT7	Open sea	0.62348	0.01007	2.8999999999999995e-129	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.44667	0.00726	8.899999999999999e-129	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02328793	chr1:6446234	1	6446234	ACOT7	Open sea	0.6397	0.0104	9.6e-129	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.34445	0.00598	1.5000000000000001e-123	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26250989	chr1:6333502	1	6333502	ACOT7	Open sea	0.23852	0.00458	1.1e-115	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24312879	chr1:6422118	1	6422118	ACOT7	Open sea	0.26485	0.00511	3.6e-115	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.23442	0.0047	3.3e-112	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.15007	0.00324	1.5e-106	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-	-	2.05e-89	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	0.08866	0.00261	1.9e-83	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	0.11502	0.00373	1.5e-76	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.11924	0.00398	1.6000000000000001e-74	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.147007	0.00816687	1.141107e-71	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	0.26199	0.00954	1.3e-68	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06834177	chr1:6333843	1	6333843	ACOT7	Open sea	0.0012	None	3.3e-68	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	0.24768	0.00926	8.4e-67	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-	-	1.02e-65	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	0.08134	0.00322	4.1e-63	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24563804	chr1:6452882	1	6452882	ACOT7	Island	0.06085	0.00245	4.7e-62	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.135588	0.00818032	3.803386e-61	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10967178	chr1:6454278	1	6454278	ACOT7	South shore	0.04167	0.00172	1.8e-60	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	-	-	1.69e-58	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11346669	chr1:6342159	1	6342159	ACOT7	South shore	0.0021	None	1.9999999999999999e-56	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0028	None	3.4999999999999995e-55	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.128112	0.00818853	9.894242e-55	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0043	None	2.3999999999999998e-54	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.04229	0.00198	1.2e-52	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg00777636	chr1:6446216	1	6446216	ACOT7	Open sea	-	-	4.23e-50	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.121708	0.00819519	1.564962e-49	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.121379	0.00819552	2.8457e-49	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-	-	3.0999999999999996e-49	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11690194	chr1:6339954	1	6339954	ACOT7	Island	0.03674	0.00189	1.8e-47	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04354126	chr1:6338812	1	6338812	ACOT7	North shore	0.04906	0.00253	3.2e-47	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05591235	chr1:6405672	1	6405672	ACOT7	Open sea	0.04827	0.00252	1.5e-46	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22171613	chr1:6396134	1	6396134	ACOT7	Open sea	0.072	0.00381	9.9e-46	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21156684	chr1:6411612	1	6411612	ACOT7	Open sea	0.05472	0.00291	1.4e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	3.22381	0.11433	1.55e-45	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	0.02974	0.00158	1.7e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.116464	0.00820038	1.775915e-45	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	2.57438	0.09184	2.47e-45	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg02328793	chr1:6446234	1	6446234	ACOT7	Open sea	-	-	2.89e-44	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.112557	0.0082041	1.419049e-42	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	-	-	1.61e-42	-	23526956_clear_cell_renal_carcinoma
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16429975	chr1:6445632	1	6445632	ACOT7	Open sea	-	-	6.739999999999999e-42	-	23526956_clear_cell_renal_carcinoma
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-6	0.4502	1.6e-40	-	28069425_total_serum_ige_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.108754	0.0082076	7.605871e-40	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.10853	0.0082078	1.0928199999999999e-39	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.108404	0.00820791	1.3399980000000001e-39	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.106455	0.00820965	3.0517309999999996e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	2.33425	0.10794	9.35e-37	-	25282492_fetal_vs_adult_liver
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-5.3	0.4189	1.1e-36	-	28069425_total_serum_ige_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.103617	0.00821213	2.610309e-36	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.103406	0.00821231	3.615142e-36	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	-1.24286	0.05889	5.59e-36	-	25282492_fetal_vs_adult_liver
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-4.1	0.3358	2.7e-34	-	28069425_total_serum_ige_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0998564	0.0082153	7.854615e-34	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.03018	0.00204	1.2e-33	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16049283	chr1:6419606	1	6419606	ACOT7	Open sea	0.06962	0.00476	3.9000000000000004e-33	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-1.07	0.09	1.2e-32	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0971256	0.00821754	4.337828e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-4.87	0.4158	1.1100000000000001e-31	-	28069425_total_serum_ige_puerto_ricans_only
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-5.83	0.4986	1.37e-31	-	28069425_total_serum_ige_puerto_ricans_only
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	-	-	1.49e-31	-	24500968_pancreatic_ductal_adenocarcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	0.01784	0.00127	2.4e-31	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.87	0.077	6.8e-30	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-5.25	0.4649	1.44e-29	-	28069425_total_serum_ige_puerto_ricans_only
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-	-	1.27e-28	-	26500701_sex_kora_f4
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.99	0.09	2.8000000000000002e-28	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0907969	0.00822247	3.077558e-28	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0907017	0.00822254	3.500757e-28	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.090596	0.00822262	4.0382130000000003e-28	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-1.38935	0.08566	4.89e-28	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0903889	0.00822277	5.3398e-28	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0898383	0.00822318	1.1189470000000001e-27	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06834177	chr1:6333843	1	6333843	ACOT7	Open sea	0.0039	None	8.800000000000001e-27	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0874101	0.00822497	2.769239e-26	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0871758	0.00822514	3.756473e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0865053	0.00822562	8.949885999999999e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0859127	0.00822604	1.9171699999999999e-25	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.04503	0.00373	2.1e-25	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.79	0.076	4.2e-25	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0850981	0.00822662	5.416777e-25	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0848758	0.00822678	7.179615e-25	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0848691	0.00822678	7.24025e-25	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	0.0023	None	1.0000000000000001e-24	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.00667	0.00065	1.2999999999999998e-24	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.119	0.00875	1.3999999999999999e-24	None	32795589_Kyung-WK_eosinophilia_discovery
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-0.123	0.00904	1.7999999999999997e-24	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0838732	0.00822748	2.534629e-24	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0838415	0.0082275	2.6372600000000002e-24	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0827853	0.00822823	9.796623e-24	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0827015	0.00822829	1.0863720000000001e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0517	0.00452	1.8e-23	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0822539	0.00822859	1.884024e-23	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.136	0.01037	1.9e-23	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0820359	0.00822874	2.4608650000000002e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0849315	0.00852403	2.6042020000000003e-23	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.080739	0.00822962	1.187942e-22	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.080643	0.00822968	1.3333230000000001e-22	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	0.01979	0.00178	1.6000000000000002e-22	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0798491	0.00823021	3.448668e-22	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg26250989	chr1:6333502	1	6333502	ACOT7	Open sea	-	-	5.29e-22	-	24500968_pancreatic_ductal_adenocarcinoma
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.248829	0.0257999	5.850125e-22	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.079324	0.00823055	6.43233e-22	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0816184	0.00849621	8.705429e-22	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11714702	chr1:6362473	1	6362473	ACOT7	Open sea	0.00032	None	1.1e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0822592	0.00861378	1.502375e-21	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0785249	0.00823108	1.648193e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0784502	0.00823113	1.798844e-21	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0780313	0.0082314	2.933096e-21	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0778013	0.00823154	3.832432e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00777636	chr1:6446216	1	6446216	ACOT7	Open sea	0.00017	None	4.1e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0777043	0.00823161	4.288925e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0774335	0.00823178	5.8673109999999996e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0769834	0.00823207	9.855234e-21	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0769143	0.00823211	1.0668189999999999e-20	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-3.2	0.348	1.1e-20	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-	-	1.28e-20	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0765088	0.00823237	1.697056e-20	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0024	None	2.1e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0758258	0.0082328	3.688656e-20	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15100947	chr1:6333867	1	6333867	ACOT7	Open sea	0.0013	None	4.4e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	-	-	7.2e-20	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0752031	0.00823319	7.440885999999999e-20	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg11346669	chr1:6342159	1	6342159	ACOT7	South shore	-	-	7.65e-20	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0750402	0.00823329	8.932496e-20	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0782085	0.00858516	9.309883e-20	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-7.99	0.844	1e-19	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg26570804	chr1:6352357	1	6352357	ACOT7	Open sea	-0.4812	0.0535	2.24e-19	-	25650246_gestational_age
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg06834177	chr1:6333843	1	6333843	ACOT7	Open sea	-	-	2.97e-19	-	24500968_pancreatic_ductal_adenocarcinoma
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16170708	chr1:6390830	1	6390830	ACOT7	Open sea	-0.56765	0.0633	3.1e-19	-	25650246_gestational_age
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.053	0.00473	3.1e-19	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0738197	0.00823404	3.466409e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14992217	chr1:6363562	1	6363562	ACOT7	Open sea	0.002	None	4.4e-19	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.073291	0.00823437	6.194130999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0731893	0.00823443	6.922846e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.028	0.00258	7.6e-19	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0729279	0.00823459	9.206907e-19	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	-3.4	0.3845	9.4e-19	-	28069425_total_serum_ige_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2318257 (gene symbol: ESPN)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2318257 (gene symbol: ESPN)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	None	None	1.4e-18	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2318257__gene_symbol__espn__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18222440	chr1:6366658	1	6366658	ACOT7	Open sea	-0.01957	0.00201	1.6e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0723238	0.00823495	1.772689e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0722466	0.008235	1.9268170000000002e-18	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg18167466	chr1:6390473	1	6390473	ACOT7	Open sea	-0.58699	0.0671	2.23e-18	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0720946	0.00823509	2.2697050000000002e-18	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.071988	0.00823515	2.545599e-18	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0718768	0.00823522	2.8685700000000003e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0718374	0.00823524	2.992542e-18	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0717869	0.00823527	3.158995e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-7.6	0.841	3.4e-18	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0711904	0.00823562	5.971921e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.282478	0.032871	9.142147e-18	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0707338	0.00823589	9.690148e-18	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg16064510	chr1:6412515	1	6412515	ACOT7	Open sea	-0.1982067	0.0231156	9.943e-18	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-	-	1.11e-17	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0700994	0.00823626	1.888563e-17	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	0.00775	0.00091	1.9e-17	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0700843	0.00823627	1.9187340000000002e-17	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	-3.81	0.449	2.16e-17	-	28069425_total_serum_ige_puerto_ricans_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0699255	0.00823636	2.2653870000000002e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.384059	0.0452729	2.3562970000000002e-17	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.44771	0.0528777	2.7195020000000006e-17	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0696735	0.00823651	2.9462490000000004e-17	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0696334	0.00823653	3.0718660000000004e-17	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0011	0.00012	3.3e-17	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0695509	0.00823658	3.34711e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0693623	0.00823669	4.070657e-17	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0692393	0.00823676	4.6233510000000004e-17	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11346669	chr1:6342159	1	6342159	ACOT7	South shore	0.0065	None	4.8e-17	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.515735	0.0615856	5.9767e-17	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0689158	0.00823694	6.456191000000001e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-0.074	0.00882	6.7e-17	None	Robert-F-Hillary_Incident_COPD_Basic_model
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg00081799	chr1:6390793	1	6390793	ACOT7	Open sea	-0.58339	0.07	7.6e-17	-	25650246_gestational_age
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.18431	0.0221	8.32e-17	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0684087	0.00823723	1.086364e-16	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	1.6	0.195	1.1e-16	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.0679803	0.00823747	1.681198e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.274971	0.0333821	1.883205e-16	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.031	0.00317	2.2e-16	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24563804	chr1:6452882	1	6452882	ACOT7	Island	0.00097	0.00012	2.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0700779	0.00857463	3.260464e-16	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.262384	0.0321854	3.801119e-16	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0671555	0.00823793	3.867743e-16	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.067077	0.00823798	4.184521e-16	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0669283	0.00823806	4.856954e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.08	0.00825	6e-16	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0665935	0.00823824	6.784278e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0665673	0.00823826	6.96371e-16	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.016	0.00162	7.9e-16	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0663766	0.00823836	8.416717e-16	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	-0.049	0.00519	0.0000000000000011	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0660644	0.00823853	0.000000000000001146592	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0660313	0.00823855	0.000000000000001184801	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0658739	0.00823864	0.000000000000001383694	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.0657773	0.00823869	0.000000000000001521875	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.48807	0.0612	0.00000000000000156	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0655016	0.00823884	0.000000000000001994823	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0654393	0.00823887	0.000000000000002120367	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0653943	0.0082389	0.000000000000002215948	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0653491	0.00823892	0.000000000000002316003	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.452597	0.0571512	0.000000000000002532475	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0652182	0.00823899	0.000000000000002631897	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08889373	chr1:6454109	1	6454109	ACOT7	Island	-0.00011	0.000014	0.0000000000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.029	0.00315	0.0000000000000046	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0645969	0.00823933	0.000000000000004811449	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0088	0.0011	0.0000000000000049	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.017	0.00187	0.0000000000000069	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0640448	0.00823962	0.000000000000008186314	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0650228	0.00836882	0.000000000000008391232	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02957924	chr1:6366307	1	6366307	ACOT7	Open sea	0.01346	0.00161	0.000000000000012	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24601967	chr1:6366496	1	6366496	ACOT7	Open sea	-0.00096	0.00012	0.000000000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0634925	0.00823991	0.00000000000001386754	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	0.0014	None	0.000000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	0.0012	0.00015	0.000000000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	-0.012	0.00132	0.000000000000018	None	32795589_Kyung-WK_eosinophilia_discovery
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.017	0.00188	0.000000000000019	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	-0.01	0.0013	0.000000000000019	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08679807	chr1:6338594	1	6338594	ACOT7	North shore	0.03931	0.00475	0.000000000000021	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-0.0627155	0.00824032	0.00000000000002889263	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0625475	0.00824041	0.00000000000003382464	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.062504	0.00824043	0.00000000000003523009	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0624463	0.00824046	0.00000000000003718507	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.015	0.002	0.000000000000039	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0623434	0.00824051	0.00000000000004093535	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	0.31406	0.0416	0.0000000000000419	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0622522	0.00824056	0.00000000000004457362	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25706257	chr1:6390530	1	6390530	ACOT7	Open sea	0.00054	None	0.000000000000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.249186	0.0331004	0.00000000000005398509	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.057	0.00656	0.00000000000006	None	32795589_Kyung-WK_atopy_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	0.00041	None	0.000000000000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0879123	0.0117272	0.00000000000006931657	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0617228	0.00824083	0.00000000000007286427	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	-0.0013	0.00017	0.00000000000008	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	-0.025	0.00286	0.000000000000086	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.061489	0.00824095	0.00000000000009041122	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	0.0614672	0.00824096	0.00000000000009224729	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0614604	0.00824096	0.00000000000009282634	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0614318	0.00824098	0.00000000000009530305	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0613845	0.008241	0.00000000000009953409	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.061383	0.008241	0.00000000000009967683	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0613625	0.00824101	0.0000000000001015712	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg11335203	chr1:6398594	1	6398594	ACOT7	Open sea	0.21025	0.0283	0.000000000000106	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0613038	0.00824104	0.0000000000001072028	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0612316	0.00824108	0.0000000000001145476	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-1.23	0.166	0.00000000000012	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-1.06	0.143	0.00000000000014	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0609961	0.0082412	0.0000000000001421164	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-1.22	0.166	0.00000000000017	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.060735	0.00824133	0.0000000000001803233	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0606838	0.00824135	0.0000000000001889184	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0713462	0.0096977	0.000000000000198027	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0605652	0.00824141	0.0000000000002104142	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0605621	0.00824142	0.0000000000002110133	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.060486	0.00824145	0.0000000000002260806	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0860766	0.0117407	0.0000000000002395042	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.018	0.00215	0.00000000000024	None	32795589_Kyung-WK_atopy_discovery
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	-0.037	0.00441	0.00000000000024	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0603508	0.00824152	0.0000000000002555302	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.011	0.0016	0.00000000000026	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0603226	0.00824154	0.0000000000002621361	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.0603075	0.00824154	0.0000000000002657352	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0602986	0.00824155	0.0000000000002678774	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0629174	0.00860953	0.0000000000002853986	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0601792	0.00824161	0.0000000000002983635	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0601022	0.00824165	0.0000000000003198075	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.00092	0.00013	0.00000000000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-0.059	0.00708	0.00000000000036	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0599585	0.00824172	0.0000000000003639777	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0599582	0.00824172	0.0000000000003640459	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.059818	0.00824179	0.0000000000004128993	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0597911	0.0082418	0.0000000000004229735	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg03961030	chr1:6333796	1	6333796	ACOT7	Open sea	-0.20681	0.0286	0.000000000000474	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0596134	0.00824189	0.0000000000004958952	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.069	0.00832	0.00000000000057	None	32795589_Kyung-WK_atopy_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	2.5	0.343	0.00000000000067	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0592562	0.00824206	0.0000000000006817464	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	Meta-analysis	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1999	3	35.7	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-	-	0.000000000000695	-	26500701_sex_metaanalysis
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-1.73	0.241	0.0000000000007	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.039	0.00473	0.00000000000079	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0614765	0.00858581	0.0000000000008436082	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17236617	chr1:6454202	1	6454202	ACOT7	South shore	0.00027	0.000038	0.0000000000009	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.213647	0.0298818	0.0000000000009041958	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-0.0607031	0.00849167	0.0000000000009184158	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-1.75	0.245	0.00000000000092	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.189772	0.0266182	0.000000000001047964	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-0.0611697	0.00857956	0.000000000001052822	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0586224	0.00824237	0.000000000001193875	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848865	chr1:6324897	1	6324897	ACOT7	South shelf	-0.00078	0.00011	0.0000000000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0612458	0.00861705	0.000000000001236056	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.058448	0.00824246	0.000000000001391451	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.08355	0.011789	0.000000000001431866	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0583077	0.00824252	0.000000000001573294	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.016	0.0023	0.0000000000016	None	33450751_Mulder-RH_sex_discovery
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	0.0055	0.00069	0.0000000000017	None	33564054_Kashima-K_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.210372	0.0297914	0.000000000001709676	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0581991	0.00824258	0.000000000001729986	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0579772	0.00824268	0.000000000002099085	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-0.0598824	0.00853269	0.000000000002349381	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0589462	0.00840139	0.000000000002379047	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0577573	0.00824279	0.000000000002540827	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0577543	0.00824279	0.000000000002547273	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0576794	0.00824283	0.00000000000271801	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0598505	0.00856653	0.000000000002938773	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0146	0.00212176	0.00000000000297	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0575635	0.00824288	0.000000000003004719	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0574616	0.00824293	0.000000000003280902	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0599216	0.00859668	0.000000000003297161	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0088	0.0013	0.0000000000034	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.0597491	0.00858259	0.000000000003505731	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-0.0573005	0.00824301	0.000000000003769148	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg11392940	chr1:6328437	1	6328437	ACOT7	Open sea	-0.02	0.00252	0.0000000000038	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0571971	0.00824305	0.000000000004119545	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.05717	0.00824307	0.000000000004216338	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0571012	0.0082431	0.000000000004472882	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00081799	chr1:6390793	1	6390793	ACOT7	Open sea	0.00091	None	0.0000000000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0592167	0.00856762	0.000000000004986752	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0569417	0.00824318	0.000000000005126975	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.18903	0.0274	0.0000000000053	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0568874	0.0082432	0.000000000005370591	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0591291	0.00858996	0.000000000006076409	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0567355	0.00824327	0.000000000006113557	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09106198	chr1:6366590	1	6366590	ACOT7	Open sea	-0.00068	0.000099	0.0000000000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0567186	0.00824328	0.000000000006202291	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.0584056	0.0084976	0.000000000006531726	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0588994	0.0085706	0.000000000006574113	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.056621	0.00824333	0.000000000006739489	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0566039	0.00824333	0.000000000006838132	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0565755	0.00824335	0.000000000007005149	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0565199	0.00824337	0.00000000000734388	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.204368	0.0298171	0.000000000007421507	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.434914	0.0634648	0.00000000000748418	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0564732	0.00824339	0.000000000007640176	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	-0.013	0.0019	0.0000000000077	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0564448	0.00824341	0.000000000007826524	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	-0.00099	0.00015	0.0000000000083	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.0012	0.00018	0.0000000000084	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0563487	0.00824345	0.000000000008490157	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0563404	0.00824346	0.000000000008550243	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14992217	chr1:6363562	1	6363562	ACOT7	Open sea	-0.0015	0.00022	0.0000000000092	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.230615	0.0338173	0.000000000009426522	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	0.30068	0.0441	0.00000000000955	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.42274	0.0620272	0.00000000000971104	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-0.05755	0.00844731	0.000000000009943057	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0561541	0.00824354	0.00000000001000745	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0561462	0.00824355	0.00000000001007474	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.180081	0.0264502	0.00000000001020079	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.05613	0.00824355	0.00000000001021261	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.359553	0.053038	0.0000000000124779	None	39706196_Hannah-M.-Smith_body_fat_discovery
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.04	0.0052	0.000000000013	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00777636	chr1:6446216	1	6446216	ACOT7	Open sea	0.00056	None	0.000000000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24601967	chr1:6366496	1	6366496	ACOT7	Open sea	0.01442	0.00201	0.000000000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00506442	chr1:6340054	1	6340054	ACOT7	Island	-0.01354	0.00189	0.000000000015	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	0.0092	0.0014	0.00000000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0577346	0.00861207	0.00000000002103146	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.026	0.00342	0.000000000022	None	32795589_Kyung-WK_atopy_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.241181	0.0360288	0.00000000002232946	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02957924	chr1:6366307	1	6366307	ACOT7	Open sea	0.001	None	0.000000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0551359	0.00824401	0.0000000000234441	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0575805	0.00861319	0.00000000002390142	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.220616	0.0330182	0.00000000002431132	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery adjusted for cell counts	Table S5	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-6.5	-	0.000000000026	-	28069425_total_serum_ige_discovery_adjusted_for_cell_counts
Petersen A-K	KORA F4	24014485	2013-09-06	M33884_X-12442	EFO_0004727, EFO_0004725	no snps model	Table S2	M33884_X-12442	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	6.17	0.13	0.000000000026	None	24014485_Petersen-A-K_m33884_x-12442_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	-0.0550071	0.00824407	0.00000000002608028	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0548879	0.00824412	0.00000000002877949	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.036	0.00482	0.000000000029	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0548487	0.00824414	0.00000000002972534	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.0058	0.00079	0.000000000032	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0544978	0.0082443	0.00000000003966395	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.054474	0.00824431	0.00000000004044275	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	0.02804	0.00401	0.000000000042	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.054372	0.00824436	0.00000000004396235	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.077687	0.0117882	0.00000000004540604	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-0.013	0.002	0.000000000049	None	33450751_Mulder-RH_sex_discovery
Dogan MV	-	28686328	2017-07-07	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	1597	1	67	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.61425711	0.0937	0.0000000000544	-	28686328_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.05621	0.00858166	0.00000000005944739	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0560367	0.00858366	0.00000000006870961	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.302307	0.0463209	0.00000000006916296	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.308113	0.0472358	0.0000000000708901	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0557462	0.00856501	0.00000000007832361	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0535741	0.00824471	0.00000000008402106	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0557297	0.00859258	0.0000000000910906	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg09513469	chr1:6421502	1	6421502	ACOT7	Open sea	0.15774	0.0243	0.0000000000911	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.053455	0.00824477	0.00000000009247668	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0558715	0.00861973	0.0000000000935204	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0534086	0.00824479	0.00000000009599872	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0534077	0.00824479	0.00000000009606851	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0625315	0.00965746	0.00000000009786842	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0533576	0.00824481	0.0000000001000106	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0532716	0.00824485	0.0000000001071494	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16170708	chr1:6390830	1	6390830	ACOT7	Open sea	0.00094	None	0.00000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0625478	0.0097036	0.0000000001185592	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Petersen A-K	KORA F4	24014485	2013-09-06	M33884_X-12442	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M33884_X-12442	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	5.82	0.13	0.00000000012	None	24014485_Petersen-A-K_m33884_x-12442_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.053041	0.00824495	0.0000000001288646	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0015	None	0.00000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0530045	0.00824497	0.0000000001326682	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06661083	chr1:6383902	1	6383902	ACOT7	Open sea	-0.0529951	0.00824497	0.0000000001336716	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0529245	0.008245	0.0000000001414094	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0617548	0.00966021	0.0000000001679126	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0526055	0.00824514	0.0000000001821848	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0525386	0.00824517	0.0000000001920921	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0525239	0.00824517	0.0000000001943285	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	0.035	0.00492	0.00000000022	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0530959	0.0083631	0.000000000223345	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0612938	0.00965666	0.0000000002255598	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26896160	chr1:6454004	1	6454004	ACOT7	Island	0.00039	0.000061	0.00000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0544261	0.00858072	0.0000000002321962	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.253227	0.0399575	0.0000000002394469	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0522209	0.00824531	0.0000000002467975	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19267259	chr1:6453427	1	6453427	ACOT7	Island	1.519767	0.2403	0.000000000252	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0520666	0.00824537	0.0000000002785799	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG2 protein levels (SeqId = 7258-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG2 protein levels (SeqId = 7258-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone marrow proteoglycan	774	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.57	0.09	0.00000000028	None	Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0519656	0.00824542	0.000000000301518	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.051941	0.00824543	0.0000000003073814	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0519227	0.00824543	0.000000000311823	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0518183	0.00824548	0.0000000003383234	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.011	0.0017	0.00000000034	None	33450751_Mulder-RH_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.359976	0.0573205	0.0000000003465156	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0517383	0.00824551	0.0000000003600913	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0517079	0.00824553	0.0000000003687276	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0516017	0.00824557	0.000000000400503	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0515624	0.00824559	0.0000000004129234	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0607685	0.00972532	0.0000000004259149	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.3107	0.0497785	0.0000000004425762	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg20630887	chr1:6417823	1	6417823	ACOT7	Open sea	-0.00929	0.00151704	0.000000000457	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0514292	0.00824565	0.000000000457892	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0514126	0.00824565	0.0000000004638088	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0515306	0.00827581	0.0000000004894876	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	-0.295375	0.0474832	0.0000000005060183	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06661083	chr1:6383902	1	6383902	ACOT7	Open sea	-0.0512613	0.00824572	0.0000000005213977	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0512059	0.00824574	0.0000000005441696	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.04931	0.00755	0.00000000056	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0529607	0.00854382	0.0000000005845038	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.05101	0.00824582	0.0000000006328292	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0509994	0.00824583	0.0000000006380328	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0509353	0.00824585	0.0000000006702201	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16429975	chr1:6445632	1	6445632	ACOT7	Open sea	-0.12074	0.0196	0.000000000738	-	25650246_gestational_age
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-10.2	1.7	0.00000000075	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0507669	0.00824592	0.0000000007625714	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0507477	0.00824593	0.0000000007738689	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.233298	0.0379186	0.0000000007789547	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0506282	0.00824598	0.000000000847876	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0618387	0.0100789	0.0000000008709222	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0591056	0.00963505	0.0000000008766036	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0505663	0.00824601	0.0000000008888455	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0505217	0.00824603	0.0000000009195749	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16743939	chr1:6411335	1	6411335	ACOT7	Open sea	-0.0504916	0.00824604	0.0000000009409382	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0504577	0.00824605	0.0000000009655336	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.056	0.00923	0.00000000098	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	0.0022	None	0.000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17429065	chr1:6453910	1	6453910	ACOT7	Island	-0.00029	0.000047	0.000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0570528	0.00934125	0.00000000103683	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.252658	0.0413865	0.000000001049917	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0502862	0.00824613	0.00000000109989	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	1.4	0.23	0.0000000011	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg08848865	chr1:6324897	1	6324897	ACOT7	South shelf	0.0751	0.0123	0.00000000111	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0591989	0.00971464	0.000000001130359	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg21156684	chr1:6411612	1	6411612	ACOT7	Open sea	-0.01454	0.0024	0.00000000114	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0501844	0.00824186	0.000000001164776	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0501755	0.00824617	0.000000001196142	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.3882	0.0638948	0.00000000126105	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0500642	0.00824622	0.000000001301093	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0499909	0.00824625	0.000000001375121	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.06864	0.0113	0.00000000138	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.0499768	0.00824625	0.000000001389868	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	-0.0498824	0.00824629	0.000000001492267	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0498769	0.0082463	0.000000001498389	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19308185	chr1:6363596	1	6363596	ACOT7	Open sea	-0.0008	0.00013	0.0000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0498576	0.0082463	0.000000001520384	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0497339	0.00824635	0.000000001668394	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Xu CJ	Barn/Children Allergy Milieu Stockholm Epidemiology, Infancia y Medio Ambiente, Prevention and Incidence of Asthma and Mite Allergy	33338541	2021-01-11	Allergy	EFO_0003785	meta-analysis	Table 3	Allergy	DNA methylation	sex, batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2893	8	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0189	0.0031	0.0000000018	None	33338541_Xu-CJ_allergy_meta-analysis
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model1	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	595	2	Adults	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	1.17	0.19	0.0000000018	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0522185	0.00868087	0.000000001837588	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0495835	0.00824642	0.000000001867441	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16170708	chr1:6390830	1	6390830	ACOT7	Open sea	0.0032	None	0.0000000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0707964	0.011796	0.000000001998406	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0601567	0.0100242	0.000000002005225	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.049471	0.00824646	0.000000002031404	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.049369	0.0082465	0.000000002191985	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0493562	0.00824651	0.00000000221289	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0493137	0.00824653	0.000000002284071	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	-	-	0.00000000234	-	26857698_primary_sjogrens_syndrome_whole_blood
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg23544381	chr1:6412458	1	6412458	ACOT7	Open sea	-0.1252742	0.0209841	0.000000002373	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-1.12	0.188	0.0000000025	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0513798	0.00862556	0.000000002632818	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.206965	0.0347954	0.000000002765978	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0576956	0.00969956	0.000000002771473	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0490382	0.00824664	0.000000002802589	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.0490104	0.00824665	0.000000002860712	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0489915	0.00824666	0.000000002900978	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0489364	0.00825366	0.000000003115371	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0507389	0.00857126	0.000000003298202	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0487855	0.00824674	0.000000003377574	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0570596	0.00964594	0.000000003384473	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.84	0.142	0.0000000034	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-0.0502452	0.00850349	0.000000003523212	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0486979	0.00824678	0.000000003602704	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.048493	0.00824686	0.000000004187263	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0484593	0.00824687	0.000000004291801	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0505011	0.00859564	0.000000004314843	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0484278	0.00824688	0.0000000043922	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0484189	0.00824689	0.000000004420807	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0483587	0.00824691	0.000000004619805	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0483542	0.00824691	0.000000004634709	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.056	0.0096	0.0000000047	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.10075	0.0172071	0.000000004867554	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0482844	0.00824694	0.000000004877138	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0019	None	0.0000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.61	0.276	0.0000000049	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-1.1	0.188	0.0000000049	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0092	0.00156	0.000000005	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0504994	0.00863533	0.0000000050811	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0503567	0.00861262	0.000000005116224	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.0482131	0.00824697	0.000000005137482	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	-0.048137	0.008247	0.000000005429925	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.01198	0.00196	0.0000000055	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	ch.1.234734F	chr1:6373420	1	6373420	ACOT7	Open sea	0.0019	None	0.0000000055	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16743939	chr1:6411335	1	6411335	ACOT7	Open sea	-0.0481096	0.00824701	0.000000005539484	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0114	0.0019963	0.00000000563	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0480829	0.00824702	0.000000005647782	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0480552	0.00824703	0.000000005762688	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.042	0.00662	0.0000000061	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0479639	0.00824707	0.000000006157639	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0479436	0.00824708	0.000000006248484	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0479336	0.00824708	0.000000006294074	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	-0.247604	0.0426129	0.000000006330787	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0582446	0.0100237	0.000000006351499	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0479081	0.00824709	0.000000006411346	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0586579	0.0101315	0.00000000719685	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-1.1	0.19	0.0000000072	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17162028	chr1:6340110	1	6340110	ACOT7	Island	0.12861	0.0222	0.00000000723	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0663803	0.0114685	0.000000007265935	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18324862	chr1:6328955	1	6328955	ACOT7	Open sea	-0.01415	0.00234	0.0000000074	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0477028	0.00824717	0.000000007437082	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0476972	0.00824717	0.000000007466843	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0476898	0.00824718	0.000000007507132	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0559756	0.00969298	0.000000007857894	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18167466	chr1:6390473	1	6390473	ACOT7	Open sea	-0.00038	0.000065	0.0000000083	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.304903	0.0528951	0.000000008339281	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Everson TM	-	26292806	2015-08-21	Atopy	EFO_0002686	Discovery	Table 5	Atopy	DNA methylation	Sex and cell counts	-	M values	Illumina HumanMethylation450	Whole blood	-	367	1	18	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-1.4313	0.2486	0.00000000852	-	26292806_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0475015	0.00824725	0.000000008596459	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0868358	0.0150866	0.000000008795475	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0474521	0.00824727	0.000000008906597	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.0012	None	0.0000000093	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0473847	0.0082473	0.000000009347881	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0473742	0.0082473	0.000000009418276	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Xu K	National Health and Resilience in Veterans Study	31386212	2019-08-06	Alcohol Consumption	EFO_0004329, EFO_0007878	not adjusted for bmi	Table 2	DNA methylation	Alcohol Consumption	Age, smoking, cell composition (reference based)	Beta Values	AUDIT-C score	Illumina HumanMethylationEPIC	Saliva	None	1135	1	Adults	Males	European	cg26250989	chr1:6333502	1	6333502	ACOT7	Open sea	None	None	0.0000000095	None	31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.314343	0.0547713	0.000000009672033	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-6.3	1.1	0.00000001	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.0472279	0.00824736	0.00000001045749	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0652808	0.011401	0.00000001049039	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.011	0.00182	0.000000011	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.047116	0.0082474	0.00000001132726	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-13.2	2.3	0.000000012	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	0.17058	0.0299	0.000000012	-	25650246_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	-0.011	0.002	0.000000012	None	33450751_Mulder-RH_sex_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg24599624	chr1:6378146	1	6378146	ACOT7	Open sea	-0.01302	0.0023	0.000000012	-	23334450_rheumatoid_arthritis
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-1.4	0.245	0.000000012	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0553187	0.00971496	0.00000001263456	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0489436	0.00860699	0.00000001321428	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0468634	0.0082475	0.00000001355476	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07334723	chr1:6337401	1	6337401	ACOT7	North shelf	-0.0468457	0.00824751	0.00000001372632	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0468129	0.00824752	0.00000001404929	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.046776	0.00824753	0.00000001442101	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.268535	0.0473582	0.00000001448278	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0467658	0.00824754	0.00000001452544	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0568899	0.0100408	0.00000001490029	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-2.1	0.366	0.000000015	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0466879	0.00824757	0.00000001534804	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.262793	0.0465814	0.00000001709996	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0486777	0.00863096	0.00000001732978	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.179909	0.0319132	0.00000001752951	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.266063	0.0472137	0.00000001774923	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0530829	0.00942658	0.00000001822568	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.287038	0.0510216	0.00000001874907	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03630917	chr1:6410741	1	6410741	ACOT7	Open sea	-0.228847	0.0407562	0.00000001994149	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.53	0.273	0.00000002	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.0462474	0.00824774	0.00000002092391	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0462324	0.00824774	0.00000002114374	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0462256	0.00824775	0.00000002124599	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0461651	0.00824777	0.00000002216449	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.11452	0.0205	0.0000000228	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-0.0478669	0.00856293	0.00000002310967	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0479471	0.00857902	0.00000002326204	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.013	0.0022	0.000000024	None	32795589_Kyung-WK_atopy_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	-0.00084	0.00015	0.000000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0460178	0.00824782	0.00000002456434	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0460045	0.00824783	0.0000000247935	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.0467775	0.00839302	0.00000002542438	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	-0.06602	0.0119	0.0000000255	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0459636	0.00824785	0.00000002550902	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	-0.16891	0.030313	0.00000002551163	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	0.0459596	0.00824785	0.00000002557978	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.00042	0.000074	0.000000026	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0479562	0.00861338	0.00000002627542	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.0610816	0.0109735	0.00000002647723	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11723698	chr1:6325058	1	6325058	ACOT7	Open sea	0.002	None	0.000000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0458209	0.0082479	0.00000002816958	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.048941	0.00880978	0.00000002819635	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	0.01475	0.0027	0.0000000289	-	23334450_rheumatoid_arthritis
Spiers H	-	25650246	2015-02-03	Interaction between gestational age and sex	EFO_0005112, EFO_0000246, PATO_0000047	-	Table 4	DNA methylation	Interaction between gestational age and sex	Technical covariates	Beta values	-	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-	-	0.0000000289	-	25650246_interaction_between_gestational_age_and_sex
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0654197	0.0117876	0.00000002908699	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0457668	0.00824792	0.000000029247	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0906925	0.0163634	0.00000003034885	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.001	None	0.000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0013	0.00024	0.000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0456149	0.00824798	0.000000032489	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Xu K	National Health and Resilience in Veterans Study	31386212	2019-08-06	Alcohol Consumption	EFO_0004329, EFO_0007878	adjusted for bmi	Table 2	DNA methylation	Alcohol Consumption	Age, smoking, cell composition (reference based), body mass index	Beta Values	AUDIT-C score	Illumina HumanMethylationEPIC	Saliva	None	1135	1	Adults	Males	European	cg26250989	chr1:6333502	1	6333502	ACOT7	Open sea	None	None	0.000000033	None	31386212_Xu-K_alcohol_consumption_adjusted_for_bmi
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.195481	0.0353797	0.00000003338278	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0472988	0.00856017	0.00000003342341	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0455197	0.00824801	0.00000003469835	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.10965	0.0199	0.0000000349	-	25650246_gestational_age
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	0.0106	0.0019	0.000000035	-	27651444_smoking_current_vs_never_smoking
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-0.038	0.00631	0.000000035	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0508445	0.00922248	0.00000003585202	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	-0.0454718	0.00824803	0.00000003586178	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	-0.022	0.00372	0.000000036	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0454652	0.00824803	0.00000003602619	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0545996	0.00991772	0.00000003748274	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0533226	0.00968656	0.00000003757885	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0792492	0.0144003	0.00000003789913	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0453783	0.00824807	0.00000003824586	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0473321	0.00860794	0.00000003890986	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0645496	0.0117739	0.00000004264957	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-1.31	0.239	0.000000043	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0531729	0.00970417	0.00000004338549	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-0.0474045	0.00865185	0.00000004345089	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0457004	0.00834095	0.00000004346745	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0480286	0.008767	0.00000004363968	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0451176	0.00824816	0.00000004573485	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	-0.0123	0.0022	0.0000000458	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	0.0004	0.000073	0.000000048	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0052	0.00094	0.000000048	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.212699	0.0389701	0.00000004878161	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0449944	0.00824821	0.00000004975315	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.10073	0.0185	0.0000000522	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.186829	0.0343514	0.00000005434432	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.052803	0.00971334	0.0000000553208	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0932534	0.0171549	0.00000005537412	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.00095345	0.00017431	0.0000000561	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only adjusted for cell counts	Table E8	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-4.4	0.8102	0.0000000561	-	28069425_total_serum_ige_puerto_ricans_only_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0927809	0.0170789	0.00000005646299	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-0.0448012	0.00824828	0.00000005674729	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0467922	0.00861984	0.00000005775424	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0527383	0.00971661	0.00000005801008	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0591474	0.01092	0.00000006176063	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.00020108	3.69e-05	0.0000000628	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0445896	0.00824836	0.00000006550214	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	1.6	0.293	0.000000066	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	-	-	0.0000000705	-	26857698_primary_sjogrens_syndrome_whole_blood
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg22346119	chr1:6453452	1	6453452	ACOT7	Island	0.00414	8e-04	0.0000000705	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.044479	0.0082484	0.00000007058178	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	0.236056	0.0437919	0.00000007122593	None	39706196_Hannah-M.-Smith_bmi_discovery
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only adjusted for cell counts	Table E8	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-5.72	1.0617	0.0000000715	-	28069425_total_serum_ige_puerto_ricans_only_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0444522	0.00824841	0.00000007187169	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.0444296	0.00824842	0.00000007297388	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0444257	0.00824842	0.00000007316714	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00081799	chr1:6390793	1	6390793	ACOT7	Open sea	0.003	None	0.000000074	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0443794	0.00824844	0.00000007548697	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0503931	0.0093702	0.00000007646272	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.332427	0.0618332	0.00000007706433	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0445174	0.00828442	0.00000007834552	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0442963	0.00824847	0.00000007982692	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.184475	0.0343604	0.00000008026845	None	39706196_Hannah-M.-Smith_bmi_discovery
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model2	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	582	2	Adults	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	1.16	0.22	0.000000081	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0442421	0.00824849	0.00000008278893	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0442373	0.00824849	0.00000008305801	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Placenta	Supplementary table 9	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (genomic PCs)	M values	None	Illumina HumanMethylation450	Placenta	None	229	1	Infants	Both	European, African, Other	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	None	None	0.000000084	None	34569420_Bozack_infant_sex_placenta
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery adjusted for cell counts	Table S5	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-2.7	-	0.000000085	-	28069425_total_serum_ige_discovery_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.046196	0.00862202	0.00000008546339	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0441664	0.00824851	0.00000008710157	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0519305	0.00969866	0.00000008713571	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0518473	0.00969362	0.00000008996626	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0458481	0.0085724	0.00000009009681	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0440744	0.00824855	0.0000000926392	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0012	0.00023	0.000000093	None	33450751_Mulder-RH_age_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.227408	0.0425843	0.00000009402834	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0439814	0.00824858	0.00000009858089	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.0439537	0.00824859	0.000000100417	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0439523	0.00824859	0.0000001005101	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0439183	0.0082486	0.0000001028164	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0438927	0.00824861	0.0000001045889	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0438443	0.00824863	0.0000001080145	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05591235	chr1:6405672	1	6405672	ACOT7	Open sea	0.0013	None	0.00000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP10 protein levels (SeqId = 8479-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP10 protein levels (SeqId = 8479-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromelysin-2	774	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.48	0.09	0.00000011	None	Gadd-DA_mmp10_protein_levels__seqid___8479-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0437598	0.00824866	0.0000001142605	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0437513	0.00824867	0.0000001149084	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0437343	0.00824867	0.0000001162139	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-1.36	0.257	0.00000012	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-2.6	0.484	0.00000012	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.081561	0.0154097	0.0000001221733	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.167495	0.0317112	0.000000129411	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	-0.179481	0.0339819	0.0000001294949	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0435546	0.00824874	0.000000130916	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0510854	0.00968306	0.0000001340999	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06834177	chr1:6333843	1	6333843	ACOT7	Open sea	0.0435057	0.00824875	0.0000001352157	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0014	None	0.00000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17162028	chr1:6340110	1	6340110	ACOT7	Island	0.01081	0.00198	0.00000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.045309	0.00860448	0.0000001415889	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.182737	0.0347236	0.0000001437275	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0434039	0.00824879	0.0000001446169	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0434031	0.00824879	0.0000001447013	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0509947	0.0096981	0.0000001475007	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-1.34	0.256	0.00000015	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.178097	0.0339135	0.0000001526506	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0433028	0.00824883	0.0000001545764	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0450411	0.00858419	0.0000001567611	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Battram T	GEO	27886173	2020-09-15	Ulcerative colitis	EFO_0000729	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Ulcerative colitis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	163	1	Adults	Both	European	cg11723698	chr1:6325058	1	6325058	ACOT7	Open sea	0.0993	0.018	0.00000016	None	27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0703805	0.0134232	0.0000001600159	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.04324	0.00824885	0.000000161103	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07334723	chr1:6337401	1	6337401	ACOT7	North shelf	-0.248472	0.0474831	0.0000001687744	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0405043	0.00774641	0.0000001729694	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0460138	0.00880012	0.0000001729921	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0523199	0.0100072	0.0000001735067	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0431269	0.00824889	0.0000001735106	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.193757	0.03707	0.0000001744951	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.043104	0.0082489	0.0000001761376	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0430927	0.0082489	0.0000001774488	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.192379	0.0368313	0.0000001778382	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0430758	0.00824891	0.0000001794217	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0430643	0.00824891	0.0000001807753	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.0430515	0.00824892	0.0000001822985	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0481772	0.00923497	0.0000001845026	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0429994	0.00824893	0.0000001886101	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG2 protein levels (SeqId = 7258-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG2 protein levels (SeqId = 7258-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone marrow proteoglycan	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.4	0.077	0.00000019	None	Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0449545	0.00862626	0.000000190006	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0429767	0.00824894	0.0000001914303	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0429374	0.00824896	0.0000001964144	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	0.0025	0.00048	0.0000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13615077	chr1:6381022	1	6381022	ACOT7	Open sea	-0.0429076	0.00824897	0.000000200275	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	0.23637	0.0454633	0.000000202488	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0428534	0.00824899	0.0000002074725	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0428499	0.00824899	0.000000207946	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04354126	chr1:6338812	1	6338812	ACOT7	North shore	-0.00038	0.000074	0.00000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0520524	0.0100326	0.0000002150269	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0589247	0.0113587	0.0000002158568	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0427848	0.00824901	0.0000002169467	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	0.18827	0.036325	0.0000002207467	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	-0.0427508	0.00824902	0.0000002218026	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0427297	0.00824903	0.0000002248594	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0426974	0.00824904	0.000000229639	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0426828	0.00824905	0.0000002318264	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0523003	0.0101103	0.0000002334108	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26896160	chr1:6454004	1	6454004	ACOT7	Island	0.0021	0.0004	0.00000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0425601	0.00824909	0.0000002510079	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0425406	0.0082491	0.0000002541951	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0425295	0.0082491	0.0000002560401	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0071	0.0014	0.00000026	-	27651444_smoking_current_vs_never_smoking
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.042	0.00825	0.00000027	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0496989	0.00967104	0.0000002798405	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	0.0423854	0.00824915	0.0000002810131	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09513469	chr1:6421502	1	6421502	ACOT7	Open sea	-0.0428472	0.00834013	0.0000002820226	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0422932	0.00824918	0.0000002982199	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0439917	0.00858232	0.000000299959	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.0004	0.000078	0.0000003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15100947	chr1:6333867	1	6333867	ACOT7	Open sea	0.0038	None	0.0000003	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-0.042271	0.00824919	0.000000302499	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0495579	0.00967315	0.000000304141	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0625551	0.0122206	0.0000003113643	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.331887	0.0649	0.000000312	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0422194	0.00824921	0.0000003126961	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.0421955	0.00824922	0.0000003175485	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0497041	0.00973095	0.0000003299487	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0490525	0.00961175	0.0000003378077	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0447946	0.00877929	0.0000003397401	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0420788	0.00824926	0.0000003422246	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0420725	0.00824926	0.0000003436166	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0420575	0.00824927	0.0000003469164	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0420441	0.00824927	0.0000003499146	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0600438	0.0117839	0.0000003523297	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11654006	chr1:6324428	1	6324428	ACOT7	South shelf	0.01088	0.00206	0.00000036	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Current vs never smoking meta-analysis in European samples	Table S1	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	912	5	Adults	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	None	None	0.00000036	None	33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0435592	0.00855699	0.0000003615723	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.041971	0.0082493	0.0000003666667	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0419252	0.00824931	0.0000003775552	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09106198	chr1:6366590	1	6366590	ACOT7	Open sea	0.00063	None	0.00000038	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11654006	chr1:6324428	1	6324428	ACOT7	South shelf	0.288292	0.056796	0.0000003896469	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0430908	0.00849328	0.0000003953063	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0566195	0.0111661	0.0000004012794	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg17429065	chr1:6453910	1	6453910	ACOT7	Island	1.546994	0.3055	0.00000041	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0587286	0.0115936	0.0000004120697	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	0.199494	0.0393874	0.0000004125905	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.110387	0.0218	0.000000418	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0417583	0.00824937	0.000000419904	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	0.0011	0.00021	0.00000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0507129	0.0100199	0.0000004216438	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0417423	0.00824938	0.0000004241992	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0599656	0.0118519	0.0000004252122	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19308185	chr1:6363596	1	6363596	ACOT7	Open sea	0.0028	None	0.00000043	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP10 protein levels (SeqId = 8479-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP10 protein levels (SeqId = 8479-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromelysin-2	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.39	0.077	0.00000043	None	Gadd-DA_mmp10_protein_levels__seqid___8479-4__somascan_protein_measurement
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0028	5e-04	0.00000043	-	27651444_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.00278	0.00055	0.00000043	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	-0.0417078	0.00824939	0.0000004336119	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0416117	0.00824942	0.0000004608682	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Chatziioannou A	EnviroGenomarkers project consortium	28225026	2017-02-22	Tobacco smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Current vs never smoking	Age, sex, body mass index, study centre and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	454	2	52	Both	None	cg24563804	chr1:6452882	1	6452882	ACOT7	Island	-	-	0.000000462	-	28225026_tobacco_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0580784	0.0115277	0.0000004756262	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0415502	0.00824944	0.0000004791894	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0415021	0.00824946	0.0000004939951	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0414898	0.00824946	0.0000004978273	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.056	0.01123	0.0000005	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.15991	0.0318033	0.0000005003406	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0609824	0.0121306	0.00000050366	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0573273	0.0114073	0.0000005080335	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0483054	0.0096137	0.0000005103101	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.041447	0.00824948	0.0000005114784	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0414171	0.00824949	0.0000005212427	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.275008	0.0548263	0.0000005328281	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.275546	0.0549518	0.0000005374923	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0430365	0.00858727	0.0000005459278	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg08679807	chr1:6338594	1	6338594	ACOT7	North shore	-1.556002	0.311	0.000000564	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0431786	0.00862947	0.0000005691588	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0412643	0.00824954	0.0000005738904	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0412386	0.00824955	0.0000005832472	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	-0.0421728	0.00843985	0.0000005894138	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG2 protein levels (SeqId = 7258-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG2 protein levels (SeqId = 7258-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone marrow proteoglycan	774	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-0.94	0.188	0.00000059	None	Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18222440	chr1:6366658	1	6366658	ACOT7	Open sea	-0.0411884	0.00824956	0.0000006019544	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00506442	chr1:6340054	1	6340054	ACOT7	Island	-0.202236	0.0405305	0.0000006102301	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	-0.265521	0.0532386	0.0000006176831	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.284941	0.0571691	0.0000006282506	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0411193	0.00824959	0.0000006286268	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.190534	0.0382494	0.0000006374497	None	39706196_Hannah-M.-Smith_bmi_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg08889373	chr1:6454109	1	6454109	ACOT7	Island	1.525086	0.3064	0.000000644	-	27105112_hiv_infection_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.199445	0.0400667	0.0000006492414	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0410542	0.00824961	0.0000006547658	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	0.0012	None	0.00000066	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0481181	0.00967327	0.0000006621435	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery adjusted for cell counts	Table S5	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-4.5	-	0.00000067	-	28069425_total_serum_ige_discovery_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0409993	0.00824963	0.0000006776475	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0409921	0.00824963	0.0000006806995	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0409761	0.00824964	0.0000006875306	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0428982	0.00863749	0.0000006893403	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.040945	0.00824965	0.0000007010583	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0408831	0.00824967	0.0000007286386	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	0.0408551	0.00824968	0.0000007414892	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.040833	0.00824969	0.0000007517696	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.04083	0.00824969	0.0000007531733	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0428996	0.00866897	0.0000007556385	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.198821	0.0401906	0.000000760921	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.168135	0.0339942	0.0000007646592	None	39706196_Hannah-M.-Smith_body_fat_discovery
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.00016473	3.31e-05	0.000000775	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0407776	0.0082497	0.0000007781193	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	1.7	0.352	0.00000079	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	-0.0407159	0.00824972	0.0000008085194	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.04071	0.00824973	0.0000008115176	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0406824	0.00824974	0.0000008255166	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09513469	chr1:6421502	1	6421502	ACOT7	Open sea	-0.0407096	0.00826027	0.0000008382852	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03485677	chr1:6386456	1	6386456	ACOT7	Open sea	-0.0406205	0.00824976	0.00000085782	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0433764	0.00881242	0.0000008651335	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19267259	chr1:6453427	1	6453427	ACOT7	Island	-0.000077	0.000016	0.00000087	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.229709	0.0467097	0.0000008832848	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0421601	0.0085742	0.0000008878938	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0670245	0.0136342	0.000000893216	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.00092	0.00019	0.0000009	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.040527	0.00824979	0.00000090896	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-5.72	1.139	0.00000091	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.042497	0.00865419	0.0000009178986	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0404843	0.0082498	0.0000009332922	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0425562	0.00867256	0.000000934746	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.1432	0.0292073	0.0000009524677	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	0.238501	0.0486487	0.0000009547404	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	0.0404261	0.00824982	0.0000009674333	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00506442	chr1:6340054	1	6340054	ACOT7	Island	0.0011	None	0.00000097	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.234641	0.0478928	0.0000009705135	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0414936	0.00847387	0.000000985219	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.173591	0.0354674	0.0000009950865	None	39706196_Hannah-M.-Smith_body_fat_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	-0.0054	0.0011	0.000001	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27316808	chr1:6453995	1	6453995	ACOT7	Island	0.00029	0.000058	0.000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.052	0.01072	0.000001	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0403675	0.00824984	0.000001002989	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0403673	0.00824984	0.000001003127	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0572758	0.0117165	0.000001026869	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0403041	0.00824986	0.000001042966	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	-0.0402865	0.00824987	0.000001054277	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.179894	0.0368453	0.000001056796	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0402683	0.00824987	0.000001066165	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0402538	0.00824988	0.000001075733	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0402334	0.00824989	0.000001089257	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0419593	0.0086053	0.000001094038	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-5.52	1.106	0.0000011	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0401928	0.0082499	0.00000111675	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	-0.0401745	0.00824991	0.000001129348	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0496524	0.0102072	0.000001159664	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04938922	chr1:6381902	1	6381902	ACOT7	Open sea	-0.186204	0.0382976	0.000001171545	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.250778	0.0515825	0.00000117359	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0401074	0.00824993	0.000001176815	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0400966	0.00824993	0.00000118463	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0400945	0.00824993	0.000001186103	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0400779	0.00824994	0.000001198272	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	None	None	0.0000012	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.0400506	0.00824995	0.000001218444	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0413006	0.00850972	0.00000122648	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0400363	0.00824995	0.00000122914	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0646795	0.0133415	0.000001259992	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0399779	0.00824997	0.000001273742	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0399644	0.00824998	0.000001284339	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05591235	chr1:6405672	1	6405672	ACOT7	Open sea	-0.0009	0.00019	0.0000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0028	0.00056	0.0000013	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0399302	0.00824999	0.000001311391	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.276533	0.0571678	0.000001327446	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0468234	0.0096843	0.00000134505	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0398867	0.00825	0.000001346601	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.193048	0.039933	0.000001347694	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0448466	0.00928332	0.000001373044	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22346119	chr1:6453452	1	6453452	ACOT7	Island	-0.000032	0.0000065	0.0000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0484676	0.0100437	0.000001409364	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	0.219886	0.0455723	0.000001412033	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0468265	0.00970888	0.000001427949	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0397871	0.00825003	0.000001430807	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0397673	0.00825004	0.000001448121	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	-0.0397516	0.00825005	0.000001461961	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0570116	0.0118428	0.000001493772	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.16571	0.0344447	0.000001515126	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26163576	chr1:6397707	1	6397707	ACOT7	Open sea	-0.217702	0.04529	0.000001545516	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.039647	0.00825008	0.000001557738	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0396181	0.00825009	0.000001585265	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0423145	0.008814	0.000001595647	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	1.8	0.372	0.0000016	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0465887	0.00970546	0.0000016003	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0489937	0.010208	0.00000160584	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0395948	0.0082501	0.000001607801	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.0401474	0.00837083	0.000001633753	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-0.0407481	0.00850107	0.000001656821	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0413006	0.00861669	0.000001658334	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0395425	0.00825011	0.000001659446	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0483841	0.0100991	0.000001676364	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0800455	0.0167153	0.00000169459	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-	-	0.0000017	-	26500701_sex_kora_f4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049283	chr1:6419606	1	6419606	ACOT7	Open sea	-0.013	0.0027	0.0000017	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	0.00098	0.0002	0.0000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	-0.0397196	0.00830064	0.000001725484	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.244572	0.0511513	0.000001755631	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0414149	0.00866574	0.000001777458	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0394142	0.00825016	0.000001793008	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0393849	0.00825017	0.000001825032	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0393635	0.00825017	0.000001848651	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0410925	0.00861859	0.000001879463	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.0416482	0.00873788	0.000001893529	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	0.158025	0.0331586	0.000001896907	None	39706196_Hannah-M.-Smith_bmi_discovery
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	None	None	0.0000019	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0032	None	0.0000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.041026	0.00861113	0.000001913298	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.221848	0.0466051	0.000001949885	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg17162028	chr1:6340110	1	6340110	ACOT7	Island	-0.1969	0.0413876	0.00000197549	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0479915	0.0100949	0.000002013058	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0459423	0.00966709	0.000002028836	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09513469	chr1:6421502	1	6421502	ACOT7	Open sea	-0.0392041	0.00825022	0.000002034407	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0391518	0.00825024	0.000002099215	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	-1.06	0.225	0.0000021	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Barfield R	MESA, CHS	31139831	2019-05-29	Sleepiness	NCIT_C95746, EFO_0007875	Meta analysis	Table 4	Sleepiness	DNA methylation	Sex, age, cell composition (reference based), batch effects, ancestry (genomic PCs)	None	Beta Values	Illumina HumanMethylation450	Monocytes	None	370	1	Adults	Both	African	cg11335203	chr1:6398594	1	6398594	ACOT7	Open sea	None	None	0.0000021	None	31139831_Barfield-R_sleepiness_meta_analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0409445	0.00863047	0.000002113258	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0750214	0.0158215	0.000002138934	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0391117	0.00825025	0.000002150232	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0390943	0.00825026	0.000002172732	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	0.167693	0.0353955	0.000002177999	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0390862	0.00825026	0.000002183277	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19308185	chr1:6363596	1	6363596	ACOT7	Open sea	0.0008	None	0.0000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0407495	0.00861448	0.00000226226	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0390248	0.00825028	0.000002264816	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0459751	0.00972248	0.000002280149	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0558894	0.0118235	0.000002299882	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg27316808	chr1:6453995	1	6453995	ACOT7	Island	-0.263097	0.0557	0.0000023	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0389782	0.0082503	0.000002328659	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0389708	0.0082503	0.000002339035	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.0389371	0.00825031	0.000002386426	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.045664	0.00967915	0.000002406478	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0389206	0.00825032	0.000002409968	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Kidney Disease (Estimated)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Kidney Disease (Estimated)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18318	1	Adults (18-65y)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.027	0.00567	0.0000025	None	Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.9	0.19	0.0000025	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0405908	0.00861873	0.0000025047	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.20977	0.0445568	0.000002520836	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0454654	0.00966239	0.000002556822	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04354126	chr1:6338812	1	6338812	ACOT7	North shore	0.00048	None	0.0000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10859280	chr1:6419094	1	6419094	ACOT7	Open sea	-0.138235	0.0294043	0.000002606718	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0387552	0.00825037	0.000002658912	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0406685	0.00866547	0.000002714339	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.0525972	0.0112075	0.000002716185	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.01711	0.00354	0.0000028	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0455898	0.00973364	0.000002842111	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0712519	0.0152161	0.000002856976	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0402952	0.00860666	0.000002868321	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0524209	0.0111966	0.000002868585	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0403049	0.00860955	0.000002874474	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0537528	0.0114879	0.00000290735	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0385881	0.00825042	0.000002935486	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0468684	0.0100224	0.000002945992	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0385074	0.00825045	0.000003078748	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0451761	0.00968278	0.000003104145	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.046609	0.00999125	0.00000311375	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0395977	0.00849924	0.000003205959	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	-0.0433355	0.00930201	0.000003209833	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0499571	0.0107234	0.000003210496	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0384358	0.00825047	0.000003211357	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FOLR3 protein levels (SeqId = 15495-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOLR3 protein levels (SeqId = 15495-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Folate receptor gamma	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.28	0.275	0.0000033	None	Gadd-DA_folr3_protein_levels__seqid___15495-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	0.038385	0.00825049	0.000003308826	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.039053	0.00839708	0.000003335591	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0383557	0.0082505	0.000003366194	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0383476	0.0082505	0.000003382243	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0383405	0.0082505	0.000003396424	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg11723698	chr1:6325058	1	6325058	ACOT7	Open sea	0.0686	0.01438	0.0000034	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	-1.24	0.264	0.0000034	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0426864	0.00918674	0.00000340513	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.0383224	0.00825051	0.000003432672	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0382917	0.00825052	0.000003495195	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	current asthma	MONDO_0004979	None	Table 3, Supplementary Data 1	DNA methylation	current asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	463	1	Children	Both	Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-3.7	0.788	0.0000035	None	31300640_Cardenas-A_current_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0382856	0.00825052	0.000003507571	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0382785	0.00825052	0.000003522257	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg16049283	chr1:6419606	1	6419606	ACOT7	Open sea	-	-	0.00000359	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0382368	0.00825053	0.000003609402	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0382336	0.00825053	0.000003616273	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21781706	chr1:6438350	1	6438350	ACOT7	Open sea	-0.0382226	0.00825054	0.000003639642	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-0.008	0.0017	0.0000037	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0381919	0.00825055	0.000003705587	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12493116	chr1:6408192	1	6408192	ACOT7	Open sea	-0.0381658	0.00825056	0.0000037626	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0464193	0.0100349	0.000003763734	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg20414935	chr1:6445872	1	6445872	ACOT7	Open sea	0.023	0.005	0.0000039	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0380876	0.00825058	0.000003938592	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.0391975	0.00849131	0.000003941653	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0380335	0.0082506	0.00000406475	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0389367	0.00845507	0.000004156709	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.037991	0.00825061	0.000004166814	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.0379882	0.00825061	0.000004173437	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26896160	chr1:6454004	1	6454004	ACOT7	Island	0.128165	0.0278484	0.000004207663	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26896160	chr1:6454004	1	6454004	ACOT7	Island	-0.0384909	0.00836914	0.000004277822	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0360325	0.00783611	0.000004296057	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0379319	0.00825063	0.000004312421	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0379271	0.00825063	0.000004324622	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0390925	0.00850629	0.000004348595	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0542167	0.0118045	0.00000440798	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0378924	0.00825064	0.000004412664	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0378874	0.00825064	0.000004425635	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.03788	0.00825065	0.000004444585	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0378678	0.00825065	0.000004476154	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0378664	0.00825065	0.000004479853	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0378659	0.00825065	0.000004481114	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0378637	0.00825065	0.000004486757	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.001	0.00022	0.0000045	None	33450751_Mulder-RH_age_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	0.142923	0.0311564	0.000004522004	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.15548	0.0339063	0.000004559319	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0378241	0.00825066	0.000004591271	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00777636	chr1:6446216	1	6446216	ACOT7	Open sea	-0.000091	0.00002	0.0000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0421359	0.0091979	0.000004664881	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12564995	chr1:6360121	1	6360121	ACOT7	Open sea	-0.037786	0.00825068	0.00000469377	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0377843	0.00825068	0.000004698386	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0377636	0.00825068	0.000004754958	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0444797	0.00971876	0.000004762842	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.1041575	0.0228057	0.000004944	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.0394575	0.00863952	0.000004985638	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00506442	chr1:6340054	1	6340054	ACOT7	Island	0.190021	0.041611	0.000004990879	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.152256	0.0333445	0.000004999765	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannon E	-	27572077	2016-08-30	Schizophrenia	EFO_0000692	Phase 1	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	675	1	-	Missing	European	cg03961030	chr1:6333796	1	6333796	ACOT7	Open sea	-0.009184	0.002012	0.00000502	-	27572077_schizophrenia_phase_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.0383521	0.00840425	0.000005073825	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0376479	0.00825072	0.000005084138	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.0376441	0.00825072	0.000005095091	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0406608	0.00891736	0.000005163233	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.037448	0.00822336	0.000005309672	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0440162	0.00966869	0.000005345045	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.17304	0.0380242	0.000005381226	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0391155	0.00860314	0.000005494162	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0374979	0.00825076	0.000005543149	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0399559	0.00879194	0.000005547694	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0374953	0.00825077	0.000005551445	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.043862	0.00965303	0.000005567406	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0441771	0.00972408	0.000005588412	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0438662	0.00965963	0.000005638229	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg25706257	chr1:6390530	1	6390530	ACOT7	Open sea	-1.082535	0.2386	0.00000569	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.037443	0.00825078	0.000005721038	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.231153	0.0509588	0.000005767901	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0374281	0.00825079	0.000005770153	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	0.0042	None	0.0000058	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0438273	0.00967141	0.00000589906	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23544381	chr1:6412458	1	6412458	ACOT7	Open sea	-0.0373837	0.0082508	0.000005919	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11654006	chr1:6324428	1	6324428	ACOT7	South shelf	0.00094	None	0.000006	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21781706	chr1:6438350	1	6438350	ACOT7	Open sea	-0.00993	0.00213	0.000006	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26896160	chr1:6454004	1	6454004	ACOT7	Island	-0.0379121	0.00837489	0.000006033389	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0373154	0.00825082	0.00000615562	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only adjusted for cell counts	Table E8	Total serum IgE	DNA methylation	Age, sex, asthma, cell counts and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-4.43	0.98	0.00000617	-	28069425_total_serum_ige_puerto_ricans_only_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	-0.0384289	0.00849926	0.000006190241	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0372853	0.00825083	0.000006262558	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.0372838	0.00825083	0.000006268037	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0400943	0.00888079	0.000006389549	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.038	0.00832	0.0000064	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.0372389	0.00825084	0.000006431136	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.071077	0.0157574	0.000006511393	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0394931	0.00875715	0.000006538918	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18324862	chr1:6328955	1	6328955	ACOT7	Open sea	-0.00069	0.00015	0.0000067	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0371651	0.00825087	0.000006707806	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.038596	0.00857774	0.000006862136	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	-0.0394258	0.00876364	0.000006886383	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0528884	0.011761	0.000006947603	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-3.36	0.74	0.000007	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0436498	0.00971426	0.000007064043	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.042	0.00939	0.0000071	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0370635	0.0082509	0.000007107632	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.206696	0.0460687	0.000007280823	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0535967	0.0119482	0.000007320577	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0369892	0.00825092	0.000007414453	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0396193	0.00884007	0.000007458218	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	0.162263	0.0362103	0.000007473062	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0369701	0.00825093	0.000007495478	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.036965	0.00825093	0.000007516977	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0369625	0.00825093	0.00000752793	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0448014	0.010006	0.000007611433	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0433888	0.00969072	0.000007614341	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0369332	0.00825094	0.00000765399	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0369264	0.00825094	0.000007683464	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0369131	0.00825094	0.00000774172	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11257164	chr1:6384147	1	6384147	ACOT7	Open sea	0.0369199	0.00825521	0.000007796014	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-0.0368938	0.00825095	0.000007826878	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg02328793	chr1:6446234	1	6446234	ACOT7	Open sea	1.226129	0.2744	0.00000785	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	-0.0377577	0.00844847	0.000007911188	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.0375395	0.00840014	0.000007920948	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0525746	0.0117753	0.000008073101	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0368311	0.00825097	0.000008109767	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0368277	0.00825097	0.000008125441	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.036823	0.00825097	0.000008147053	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.0391427	0.00877312	0.000008192918	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0539746	0.0121063	0.000008318638	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	0.037548	0.00842401	0.000008363151	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0367757	0.00825099	0.000008368066	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0045	None	0.0000085	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.0371962	0.00835358	0.000008541542	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-1.25	0.278	0.0000086	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0519106	0.0116679	0.00000869047	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0366696	0.00825102	0.00000888462	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0366676	0.00825102	0.000008894486	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0381491	0.00858653	0.000008940309	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0383101	0.00863195	0.000009138575	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0365627	0.00825105	0.000009435635	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0365611	0.00825105	0.000009444247	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0365549	0.00825105	0.000009477162	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0431096	0.00973209	0.000009507906	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.00010399	2.35e-05	0.00000964	-	27843151_alcohol_consumption_per_day_african_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0470796	0.0106372	0.000009671341	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Battram T	GEO	27993549	2020-09-15	Total body naevus count	EFO_0000625	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE90124	None	DNA methylation	Total body naevus count	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Skin	None	318	1	Adults	Both	European	cg25706257	chr1:6390530	1	6390530	ACOT7	Open sea	0.0002	0.000044	0.0000098	None	27993549_Battram-T_total_body_naevus_count_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse90124
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0429923	0.00972478	0.000009899664	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0364678	0.00825108	0.000009951838	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0364595	0.00825108	0.000009998334	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0047	0.0011	0.00001	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0364302	0.00825109	0.00001016367	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0364282	0.00825109	0.00001017531	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.163878	0.037137	0.00001026369	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0363867	0.0082511	0.00001041475	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0375171	0.00850991	0.00001047658	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0380289	0.00862762	0.00001051619	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0363662	0.00825111	0.00001053446	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0363415	0.00825112	0.00001068116	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	-0.036827	0.00836291	0.00001072168	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	0.0370433	0.00841328	0.00001075419	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0363257	0.00825112	0.0000107762	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0428175	0.00972723	0.00001081079	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.049999	0.011359	0.0000108163	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0378324	0.00859605	0.0000108447	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03961030	chr1:6333796	1	6333796	ACOT7	Open sea	-0.170432	0.0387363	0.00001089686	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13209388	chr1:6355060	1	6355060	ACOT7	Open sea	-0.03036	0.00673	0.000011	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	glyphosate	CHEBI_27744	discovery	10.5281/zenodo.5156585	DNA methylation	glyphosate	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	592	1	Adults	Males	European	cg25370592	chr1:6454097	1	6454097	ACOT7	Island	0.00041	0.000093	0.000011	None	34516295_Hoang_glyphosate_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0443335	0.0100841	0.00001108385	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18167466	chr1:6390473	1	6390473	ACOT7	Open sea	-0.129117	0.0293785	0.00001114268	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.036243	0.00825115	0.00001128532	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Everson TM	-	26292806	2015-08-21	High serum immunoglobulin E	EFO_0004579	-	Table 5	High serum immunoglobulin E	DNA methylation	Sex and cell counts	-	M values	Illumina HumanMethylation450	Whole blood	-	144	1	18	Both	European	cg09249800	chr1:6341287	1	6341287	ACOT7	Island	-1.959	0.4462	0.0000113	-	26292806_high_serum_immunoglobulin_e
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.03624	0.00825115	0.0000113042	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.0362336	0.00825115	0.00001134462	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.0363205	0.00828239	0.00001166479	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0516271	0.0117746	0.0000117007	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0378015	0.00862335	0.00001175335	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0499984	0.0114107	0.00001185697	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0361439	0.00825118	0.00001192523	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.0021	None	0.000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.214437	0.0489762	0.00001202586	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26250989	chr1:6333502	1	6333502	ACOT7	Open sea	-0.195825	0.0447615	0.00001221945	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.0360841	0.00825119	0.00001232828	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0516114	0.0118133	0.00001257217	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	-0.0360344	0.00825121	0.00001267287	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.0362881	0.00831341	0.00001279892	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0439723	0.0100759	0.00001285146	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0692196	0.0158632	0.00001288579	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27316808	chr1:6453995	1	6453995	ACOT7	Island	0.123959	0.0284191	0.000012969	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0072	0.0016	0.000013	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-2.45	0.553	0.000013	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Cardenas A	Project Viva	31300640	Jul 12, 2019	current asthma	MONDO_0004979	None	Table 3, Supplementary Data 1	DNA methylation	current asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	463	1	Children	Both	Other	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-1.65	0.374	0.000013	None	31300640_Cardenas-A_current_asthma
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.220116	0.0504757	0.00001302862	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.126432	0.0289984	0.00001308388	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0359524	0.00825123	0.00001326251	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0375096	0.00861205	0.0000133675	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0401175	0.00921642	0.00001353004	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16429975	chr1:6445632	1	6445632	ACOT7	Open sea	0.0359137	0.00825125	0.00001354896	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21156684	chr1:6411612	1	6411612	ACOT7	Open sea	0.17266	0.0396827	0.00001362791	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0359015	0.00825125	0.00001364084	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0358835	0.00825125	0.00001377714	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0411233	0.00945626	0.00001378164	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14671927	chr1:6415103	1	6415103	ACOT7	Open sea	-0.136842	0.03147	0.00001379153	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0379125	0.0087196	0.00001383385	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	0.0358668	0.00825126	0.00001390527	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24599624	chr1:6378146	1	6378146	ACOT7	Open sea	-0.00039	0.000089	0.000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	DES protein levels (SeqId = 12030-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DES protein levels (SeqId = 12030-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmin	774	1	Adults (18-65 years)	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	-0.73	0.168	0.000014	None	Gadd-DA_des_protein_levels__seqid___12030-82__somascan_protein_measurement
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model3	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, diabetes, hypertension, hypercholesterolemia	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	506	2	Adults	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	1	0.23	0.000014	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0358518	0.00825126	0.00001402103	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0421936	0.00971089	0.0000140226	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0419402	0.00965293	0.00001403315	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0358299	0.00825127	0.00001419147	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.0371769	0.00856315	0.00001424652	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0589707	0.0135872	0.00001433254	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0358051	0.00825128	0.00001438667	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0357938	0.00825128	0.00001447664	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0357782	0.00825129	0.00001460186	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0421228	0.00972043	0.00001477787	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0357433	0.0082513	0.00001488532	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.035727	0.0082513	0.00001501896	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0357119	0.0082513	0.00001514484	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05824903	chr1:6360355	1	6360355	ACOT7	Open sea	-0.181358	0.0419076	0.00001515766	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0356881	0.00825131	0.00001534392	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.0356657	0.00825132	0.00001553435	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02726752	chr1:6446795	1	6446795	ACOT7	Open sea	-0.0356433	0.00825133	0.00001572665	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0356428	0.00825133	0.00001573077	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0379819	0.00879357	0.00001575712	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0356265	0.00825133	0.00001587231	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.267929	0.0620589	0.00001587556	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	0.134809	0.0312299	0.00001592924	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0356167	0.00825133	0.00001595784	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15654590	chr1:6394298	1	6394298	ACOT7	Open sea	0.0356137	0.00825133	0.0000159843	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	-1.3	0.296	0.000016	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.043	0.00996	0.000016	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0356061	0.00825134	0.00001605104	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.0355925	0.00825134	0.00001617099	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0355925	0.00825134	0.0000161711	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07345250	chr1:6403279	1	6403279	ACOT7	Open sea	0.0355839	0.00825134	0.00001624753	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	0.0355321	0.00825136	0.00001671518	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.035531	0.00825136	0.00001672532	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	0.155984	0.0362402	0.00001685316	None	39706196_Hannah-M.-Smith_bmi_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.85	0.199	0.000017	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	-9.1	2.1	0.000017	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	0.00047	0.00011	0.000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Cardenas A	Project Viva	31300640	Jul 12, 2019	current asthma	MONDO_0004979	None	Table 3, Supplementary Data 1	DNA methylation	current asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	463	1	Children	Both	Other	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-3.49	0.803	0.000017	None	31300640_Cardenas-A_current_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0438438	0.0101918	0.00001704775	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.0354849	0.00825137	0.00001715235	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0354755	0.00825137	0.00001724065	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	-0.151359	0.0352082	0.00001724943	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18222440	chr1:6366658	1	6366658	ACOT7	Open sea	-0.0354723	0.00825138	0.0000172716	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.0569875	0.0132563	0.00001727492	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.208322	0.0484647	0.00001729637	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0374922	0.00872845	0.00001755048	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0354257	0.00825139	0.00001771706	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0354242	0.00825139	0.00001773132	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0368429	0.008583	0.00001777721	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0404825	0.00943353	0.00001787379	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0354057	0.00825139	0.0000179114	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg24563804	chr1:6452882	1	6452882	ACOT7	Island	0.00043	0.0001	0.000018	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Current vs never smoking meta-analysis in European samples	Table S1	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	912	5	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	None	None	0.000018	None	33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0428732	0.0100028	0.00001829732	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.035361	0.00825141	0.00001835294	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	-0.0353571	0.00825141	0.00001839198	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	-0.0353565	0.00825141	0.00001839823	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.0353535	0.00825141	0.00001842828	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0364458	0.00851549	0.00001881337	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0353134	0.00825142	0.00001883533	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	0.149483	0.0349383	0.00001891788	None	39706196_Hannah-M.-Smith_bmi_discovery
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	None	None	0.000019	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0352946	0.00825143	0.00001902966	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0352542	0.00825144	0.00001945157	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.0364136	0.00852489	0.00001954382	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0506584	0.0118617	0.00001960449	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.0352316	0.00825145	0.00001969239	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0367489	0.00860882	0.00001978011	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0431297	0.010104	0.000019797	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.208889	0.0489394	0.00001979936	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0390619	0.00915575	0.00001999227	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0026	0.00058	0.00002	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	CST1 protein levels (SeqId = 5459-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CST1 protein levels (SeqId = 5459-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cystatin-SN	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.33	0.077	0.00002	None	Gadd-DA_cst1_protein_levels__seqid___5459-33__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.034	0.00788	0.00002	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-1.13	0.265	0.00002	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26163576	chr1:6397707	1	6397707	ACOT7	Open sea	0.198219	0.0464675	0.00002002887	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0351729	0.00825146	0.00002033044	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.043346	0.0101703	0.00002038648	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15529056	chr1:6417482	1	6417482	ACOT7	Open sea	0.0348661	0.0081816	0.00002043022	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0676262	0.0158746	0.00002056767	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.0351493	0.00825147	0.00002059145	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15654590	chr1:6394298	1	6394298	ACOT7	Open sea	-0.0351429	0.00825147	0.00002066355	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0567454	0.0133252	0.00002070843	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.041256	0.00968932	0.00002076564	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0351154	0.00825148	0.00002097346	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KLHL7 protein levels (SeqId = 12625-138)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLHL7 protein levels (SeqId = 12625-138)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kelch-like protein 7	774	1	Adults (18-65 years)	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	0.7	0.165	0.000021	None	Gadd-DA_klhl7_protein_levels__seqid___12625-138__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.042	0.00979	0.000021	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0371021	0.00872236	0.00002115986	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0576734	0.0135675	0.00002142802	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.204794	0.0481925	0.00002153125	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0372715	0.00877298	0.00002165877	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Kaushal A	-	28558807	2017-05-30	Utero arsenic exposure	EFO_0004880	Discovery	Additional file 6	DNA methylation	Maternal urinary arsenic level	Offspring sex, urinary creatinine, maternal age, maternal pre-pregnancy body mass index, maternal education, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	64	1	0	Both	East Asian	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	-0.62	0.146	0.0000218	-	28558807_utero_arsenic_exposure_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	0.186438	0.0439062	0.00002184712	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0350288	0.0082515	0.00002197978	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	-0.0350253	0.00825151	0.00002202161	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0672163	0.0158598	0.0000226739	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0363554	0.00857984	0.00002276002	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	-0.154215	0.0363965	0.00002276067	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC4C protein levels (SeqId = 9094-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC4C protein levels (SeqId = 9094-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 4 member C	774	1	Adults (18-65 years)	Both	European	cg00425213	chr1:6446095	1	6446095	ACOT7	Open sea	0.83	0.196	0.000023	None	Gadd-DA_clec4c_protein_levels__seqid___9094-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPY protein levels (SeqId = 4588-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPY protein levels (SeqId = 4588-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pancreatic prohormone	774	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	0.87	0.205	0.000023	None	Gadd-DA_ppy_protein_levels__seqid___4588-1__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.229287	0.0541541	0.0000230733	None	39706196_Hannah-M.-Smith_glucose_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10859280	chr1:6419094	1	6419094	ACOT7	Open sea	0.122159	0.0288805	0.00002350194	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0499385	0.01181	0.00002366914	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0365593	0.00864598	0.00002367124	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0465588	0.0110139	0.00002379822	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0498502	0.0117929	0.00002381305	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.034873	0.00825155	0.00002390641	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.22	0.0512	0.000024	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.034858	0.00825155	0.00002410043	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0422272	0.00999693	0.00002414341	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	-0.0425445	0.0100738	0.00002422277	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	-0.034847	0.00825156	0.0000242435	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-0.0360595	0.00854768	0.00002472637	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	0.0350409	0.00830674	0.00002475494	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0348036	0.00825157	0.00002481583	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0347918	0.00825157	0.00002497426	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.15	0.272	0.000025	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15654590	chr1:6394298	1	6394298	ACOT7	Open sea	0.164368	0.0390074	0.00002524324	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0347522	0.00825158	0.00002551052	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0347521	0.00825158	0.00002551133	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0403408	0.00958039	0.00002560191	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0349043	0.00829351	0.00002584544	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	-0.0347252	0.00825159	0.00002588256	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0347	0.0082516	0.00002623435	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0346987	0.0082516	0.00002625259	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.0346952	0.0082516	0.0000263024	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	0.0346479	0.00825161	0.00002697657	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	0.0023	None	0.000027	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	-0.00066	0.00016	0.000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24563804	chr1:6452882	1	6452882	ACOT7	Island	0.0033	0.00079	0.000027	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0355006	0.00846247	0.00002744006	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0346108	0.00825162	0.00002751692	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0477566	0.0113902	0.00002771764	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0345946	0.00825163	0.0000277573	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0345933	0.00825163	0.0000277763	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02957924	chr1:6366307	1	6366307	ACOT7	Open sea	-0.00055	0.00013	0.000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CAST protein levels (SeqId = 3026-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAST protein levels (SeqId = 3026-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calpastatin	774	1	Adults (18-65 years)	Both	European	cg12493116	chr1:6408192	1	6408192	ACOT7	Open sea	-0.48	0.114	0.000028	None	Gadd-DA_cast_protein_levels__seqid___3026-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0345745	0.00825164	0.00002805668	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.160144	0.0382276	0.00002813094	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.14387	0.0343448	0.00002815966	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0345615	0.00825164	0.00002825156	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0461123	0.011013	0.00002842345	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	0.0345347	0.00825165	0.00002865831	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11714702	chr1:6362473	1	6362473	ACOT7	Open sea	-0.00318	0.00074	0.000029	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	None	None	0.000029	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	-0.034502	0.00825166	0.00002916363	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0345009	0.00825166	0.00002918094	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0344885	0.00825166	0.00002937356	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0426043	0.0102033	0.0000299008	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.042827	0.0102583	0.00002998712	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08886676	chr1:6328827	1	6328827	ACOT7	Open sea	0.01245	0.00291	0.00003	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	1.8	0.411	0.00003	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0566442	0.0135702	0.00003008339	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0477612	0.0114469	0.00003031323	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.036762	0.00881497	0.0000305804	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0343992	0.00825169	0.00003080387	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00425213	chr1:6446095	1	6446095	ACOT7	Open sea	-0.00062	0.00015	0.000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0179	0.00417	0.000031	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-	-	0.0000315	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0343552	0.0082517	0.00003153189	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16176825	chr1:6392154	1	6392154	ACOT7	Open sea	-0.188638	0.0453199	0.00003164293	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04354126	chr1:6338812	1	6338812	ACOT7	North shore	-0.183898	0.0442062	0.00003197102	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	COVID-19 Severity (Hospitalisation)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	COVID-19 Severity (Hospitalisation)	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	4232	1	Adults (18-65y)	Both	European	cg00425213	chr1:6446095	1	6446095	ACOT7	Open sea	-0.072	0.0172	0.000032	None	Robert-F-Hillary_COVID-19_Severity_(Hospitalisation)_Fully-adjusted_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.042	0.0101	0.000032	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-3.98	0.941	0.000032	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0457437	0.0109976	0.00003208788	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0343122	0.00825171	0.00003225935	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0366574	0.00881856	0.00003244949	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.0342993	0.00825171	0.00003248084	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0413076	0.00993931	0.00003257298	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02957924	chr1:6366307	1	6366307	ACOT7	Open sea	-0.141919	0.0341583	0.00003271299	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.034274	0.00825172	0.00003292031	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Kazmi N	PACE	31230546	2019-06-24	Hypertensive disorders of pregnancy	MONDO_0024664, EFO_0000537, EFO_0000668	Meta analysis unadjusted model	Table S3	DNA methylation	Hypertensive disorders of pregnancy	None	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	5242	10	Infants	Both	Unclear	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0064	0.0015	0.000033	None	31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-1.77	0.423	0.000033	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.0342517	0.00825173	0.00003331136	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	0.0342448	0.00825173	0.00003343293	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0451619	0.0108837	0.00003351128	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0342255	0.00825173	0.00003377598	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0342005	0.00825174	0.00003422574	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0440881	0.0106397	0.00003436169	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0388157	0.00936912	0.00003448161	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	-0.0341757	0.00825175	0.0000346779	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	-0.0341672	0.00825175	0.00003483314	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.0363818	0.00878728	0.0000348824	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.035708	0.00862521	0.00003493215	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.0346266	0.00836496	0.00003500317	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0341455	0.00825176	0.00003523479	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24420884	chr1:6414538	1	6414538	ACOT7	Open sea	0.0341265	0.00825176	0.00003559045	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	0.0341251	0.00825176	0.00003561629	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0341215	0.00825176	0.00003568423	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0341215	0.00825176	0.00003568479	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.03412	0.00825176	0.00003571241	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.049204	0.0119025	0.0000358618	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0400872	0.00969733	0.00003587417	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	0.0023	0.00056	0.000036	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	-0.0046	0.0011	0.000036	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CST2 protein levels (SeqId = 4324-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CST2 protein levels (SeqId = 4324-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cystatin-SA	774	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.32	0.077	0.000036	None	Gadd-DA_cst2_protein_levels__seqid___4324-33__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	0.0017	None	0.000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25370592	chr1:6454097	1	6454097	ACOT7	Island	-0.000093	0.000023	0.000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0488075	0.0118113	0.00003611696	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0505857	0.0122492	0.00003652007	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0340726	0.00825178	0.00003661581	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.045	0.01088	0.000037	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27316808	chr1:6453995	1	6453995	ACOT7	Island	0.0016	0.00038	0.000037	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.0340469	0.00825178	0.00003711618	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	0.034043	0.00825179	0.00003719224	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0470186	0.0114006	0.00003740507	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06820287	chr1:6381947	1	6381947	ACOT7	Open sea	0.0342988	0.00831991	0.00003768552	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0484525	0.0117542	0.00003774325	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0342386	0.00830638	0.00003777289	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	-0.0344395	0.00835575	0.00003782268	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	0.144314	0.0350196	0.00003790537	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-1.09	0.263	0.000038	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0352842	0.00856296	0.00003800208	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0352795	0.0085622	0.00003803357	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16743939	chr1:6411335	1	6411335	ACOT7	Open sea	0.0339979	0.0082518	0.000038085	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0339725	0.00825181	0.00003859707	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0648547	0.0157544	0.0000386593	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0339596	0.00825181	0.0000388599	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	THSD1 protein levels (SeqId = 5621-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THSD1 protein levels (SeqId = 5621-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thrombospondin type-1 domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	-0.73	0.176	0.000039	None	Gadd-DA_thsd1_protein_levels__seqid___5621-64__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21781706	chr1:6438350	1	6438350	ACOT7	Open sea	-0.0053	0.0013	0.000039	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	-0.0339416	0.00825181	0.00003922943	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0339299	0.00825182	0.00003947133	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0340779	0.00828989	0.00003964742	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0485854	0.0118199	0.00003970046	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03630917	chr1:6410741	1	6410741	ACOT7	Open sea	0.169991	0.0413588	0.00003972101	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16176825	chr1:6392154	1	6392154	ACOT7	Open sea	-0.033909	0.00825182	0.00003990602	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Zhao N	1989 CLUE II cohort	34008478	12-01-2020	lung cancer	None	None	Supplemental Table 1	lung cancer	DNA methylation	Age, Sex, Smoking, Body mass index, batch effects, pack-years based smoking methylation score, cell composition (reference based)	None	Other	Illumina HumanMethylationEPIC	whole blood	208 cases and 222 controls. Results are given as logOR corresponding to each 1% increase of methylation beta value	430	1	Adults	Both	European	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	0.252	0.0614	0.00004	None	34008478_Zhao-N_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.041216	0.0100376	0.0000404475	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0338722	0.00825183	0.00004068343	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	0.87324	0.2129	0.0000409	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06661083	chr1:6383902	1	6383902	ACOT7	Open sea	0.0338615	0.00825184	0.00004091257	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09106198	chr1:6366590	1	6366590	ACOT7	Open sea	0.002	None	0.000041	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	-0.0085	0.0021	0.000041	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.034213	0.00833908	0.00004105043	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.0338515	0.00825184	0.00004112835	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0353736	0.00862378	0.00004120471	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06820287	chr1:6381947	1	6381947	ACOT7	Open sea	0.0340913	0.00831118	0.00004120608	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	-0.033845	0.00825184	0.00004126822	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0967558	0.0236071	0.00004157	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0338308	0.00825185	0.00004157698	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0338278	0.00825185	0.00004164128	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848865	chr1:6324897	1	6324897	ACOT7	South shelf	0.00064	None	0.000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11654006	chr1:6324428	1	6324428	ACOT7	South shelf	0.0029	None	0.000042	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17429065	chr1:6453910	1	6453910	ACOT7	Island	0.00028	None	0.000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0365275	0.00891488	0.00004201323	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-0.240651	0.0587638	0.00004236974	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0501275	0.0122434	0.00004258323	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	0.0337833	0.00825186	0.00004262216	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	0.0343241	0.00838777	0.00004296492	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg07906050	chr1:6377509	1	6377509	ACOT7	Open sea	-3.03	0.734	0.000043	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0353324	0.00863582	0.00004311216	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.034739	0.00849343	0.00004334907	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08937813	chr1:6334700	1	6334700	ACOT7	Open sea	-0.0341504	0.00835688	0.00004402697	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0337175	0.00825188	0.00004411251	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.039376	0.00963871	0.00004427358	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	0.0347498	0.00851287	0.00004488191	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03915541	chr1:6340443	1	6340443	ACOT7	North shore	-0.0335086	0.00821002	0.0000449958	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0026	0.00062	0.000045	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	PRCP protein levels (SeqId = 5722-78)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRCP protein levels (SeqId = 5722-78)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysosomal Pro-X carboxypeptidase	774	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.73	0.178	0.000045	None	Gadd-DA_prcp_protein_levels__seqid___5722-78__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0637685	0.0156249	0.00004503946	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10859280	chr1:6419094	1	6419094	ACOT7	Open sea	-0.0340624	0.00834914	0.00004532227	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.035276	0.00864713	0.00004537004	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15180351	chr1:6385101	1	6385101	ACOT7	Open sea	-0.173567	0.0425694	0.00004576171	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0336356	0.0082519	0.00004603883	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26163576	chr1:6397707	1	6397707	ACOT7	Open sea	-0.0336354	0.0082519	0.00004604189	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0351899	0.00863355	0.00004606989	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0336311	0.0082519	0.00004614577	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24599624	chr1:6378146	1	6378146	ACOT7	Open sea	-0.0337954	0.00829766	0.00004667814	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.189576	0.046577	0.00004718617	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	-0.0335819	0.00825191	0.00004734352	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0335632	0.00825192	0.00004780542	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0351076	0.00863185	0.00004782806	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.0335524	0.00825192	0.00004807533	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08937813	chr1:6334700	1	6334700	ACOT7	Open sea	-0.0340738	0.00838025	0.00004808476	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.047959	0.0118044	0.00004873473	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0335168	0.00825193	0.00004897066	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LEFTY2 protein levels (SeqId = 15503-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LEFTY2 protein levels (SeqId = 15503-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Left-right determination factor 2	774	1	Adults (18-65 years)	Both	European	cg03630917	chr1:6410741	1	6410741	ACOT7	Open sea	0.93	0.228	0.000049	None	Gadd-DA_lefty2_protein_levels__seqid___15503-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26163576	chr1:6397707	1	6397707	ACOT7	Open sea	-0.0335103	0.00825193	0.00004913662	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.0334779	0.00825194	0.00004997173	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.033464	0.00825195	0.00005033092	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0410231	0.0101181	0.00005051583	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.033445	0.00825195	0.00005082886	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.00095	None	0.000051	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02328793	chr1:6446234	1	6446234	ACOT7	Open sea	0.00083	None	0.000051	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPING1 protein levels (SeqId = 4479-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPING1 protein levels (SeqId = 4479-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plasma protease C1 inhibitor	774	1	Adults (18-65 years)	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.52	0.128	0.000051	None	Gadd-DA_serping1_protein_levels__seqid___4479-14__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0334375	0.00825195	0.00005102667	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0334367	0.00825195	0.00005104956	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0408833	0.0100934	0.00005137458	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24871821	chr1:6398680	1	6398680	ACOT7	Open sea	0.034435	0.00850197	0.00005142976	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11078128	chr1:6336743	1	6336743	ACOT7	North shelf	-0.033407	0.00825196	0.00005184039	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	1.4	0.331	0.000052	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	0.025	0.00613	0.000052	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0333996	0.00825196	0.00005203856	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20162711	chr1:6371366	1	6371366	ACOT7	Open sea	0.0333982	0.00825197	0.00005207767	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	0.0333821	0.00825197	0.00005251347	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	0.134414	0.0332406	0.00005284772	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0348699	0.00862467	0.00005303112	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0333466	0.00825198	0.00005348671	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0348435	0.00862265	0.00005351213	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0333225	0.00825199	0.00005415491	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09106198	chr1:6366590	1	6366590	ACOT7	Open sea	-0.172481	0.0427456	0.00005481119	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0332981	0.00825199	0.00005484082	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0588629	0.0145891	0.00005494659	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3506-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3506-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg09507999	chr1:6399450	1	6399450	ACOT7	Open sea	-0.85	0.211	0.000055	None	Gadd-DA_lta_protein_levels__seqid___3506-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08679807	chr1:6338594	1	6338594	ACOT7	North shore	0.0325869	0.00807842	0.00005515564	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	-0.0338385	0.008389	0.00005518857	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0332775	0.008252	0.00005542829	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	-0.0332774	0.008252	0.00005543081	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0478958	0.0118796	0.0000556417	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	0.0476323	0.0118149	0.00005569449	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.8	0.199	0.000056	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	ATP1B4 protein levels (SeqId = 9933-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ATP1B4 protein levels (SeqId = 9933-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein ATP1B4	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.1	0.274	0.000056	None	Gadd-DA_atp1b4_protein_levels__seqid___9933-49__somascan_protein_measurement
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-1.05	0.26	0.000056	4807	31197173_Liu-J_fasting_glucose_base_plus_bmi
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25165880	chr1:6454326	1	6454326	ACOT7	South shore	0.0075	0.0019	0.000056	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0348216	0.0086409	0.00005609301	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0332501	0.00825201	0.00005621833	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0390888	0.00971078	0.00005718765	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.105611	0.0262399	0.00005725748	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0476553	0.0118409	0.00005735084	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10770046	chr1:6446787	1	6446787	ACOT7	Open sea	-0.125702	0.0312359	0.00005738146	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0382093	0.00949494	0.00005746316	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	-0.03394	0.00843686	0.00005779254	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.180929	0.0449805	0.00005784391	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	IL1R2 protein levels (SeqId = 14133-93)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL1R2 protein levels (SeqId = 14133-93)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-1 receptor type 2	774	1	Adults (18-65 years)	Both	European	cg04354126	chr1:6338812	1	6338812	ACOT7	North shore	0.93	0.231	0.000059	None	Gadd-DA_il1r2_protein_levels__seqid___14133-93__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.1	0.274	0.000059	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDKN3 protein levels (SeqId = 14178-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDKN3 protein levels (SeqId = 14178-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase inhibitor 3	774	1	Adults (18-65 years)	Both	European	cg16733136	chr1:6404058	1	6404058	ACOT7	Open sea	-0.71	0.177	0.000059	None	Gadd-DA_cdkn3_protein_levels__seqid___14178-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.034408	0.0085669	0.00005939129	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0387637	0.00965422	0.00005969013	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ENTPD2 protein levels (SeqId = 18887-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENTPD2 protein levels (SeqId = 18887-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 2	774	1	Adults (18-65 years)	Both	European	cg02995045	chr1:6419906	1	6419906	ACOT7	Open sea	0.66	0.164	0.00006	None	Gadd-DA_entpd2_protein_levels__seqid___18887-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0331222	0.00825204	0.00006004174	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05127153	chr1:6452942	1	6452942	ACOT7	Island	-0.145742	0.0363153	0.00006014445	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.033118	0.00825204	0.00006017163	P00748	41361833_Josephine_Robertson_P00748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0331029	0.00825205	0.00006063895	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.0334969	0.00835096	0.00006072351	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.033083	0.00825205	0.00006126105	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0473105	0.0118014	0.00006130519	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0330791	0.00825205	0.00006138377	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0345554	0.0086206	0.00006141802	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	0.0346313	0.00864067	0.00006155396	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0400443	0.00999247	0.00006168234	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18148314	chr1:6425319	1	6425319	ACOT7	Open sea	-0.0615217	0.0153548	0.00006187974	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10210448	chr1:6342435	1	6342435	ACOT7	South shore	0.001	None	0.000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0330573	0.00825206	0.00006207422	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0387348	0.00967432	0.00006261889	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	0.005	0.001	0.0000628	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0330176	0.00825207	0.0000633498	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0347147	0.00867814	0.00006358693	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	-0.149334	0.0373364	0.00006368925	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.133703	0.0334326	0.0000638149	None	39706196_Hannah-M.-Smith_glucose_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	0.028	0.00704	0.000064	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13549940	chr1:6390053	1	6390053	ACOT7	Open sea	0.0329841	0.00825208	0.00006444655	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16434449	chr1:6412541	1	6412541	ACOT7	Open sea	-0.0329784	0.00825208	0.00006463346	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24927687	chr1:6336519	1	6336519	ACOT7	North shelf	-0.0329708	0.00825208	0.00006488655	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0385235	0.00964211	0.00006491872	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0329673	0.00825208	0.00006500339	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0329483	0.00825209	0.00006563605	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0329432	0.00825209	0.00006580821	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-0.0058	0.0014	0.000066	None	33450751_Mulder-RH_sex_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	-0.225044	0.0564	0.0000664	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0406525	0.0101913	0.00006668958	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19838859	chr1:6328861	1	6328861	ACOT7	Open sea	0.0329135	0.0082521	0.00006681497	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0372786	0.0093475	0.00006693191	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0404922	0.0101538	0.00006699012	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09106198	chr1:6366590	1	6366590	ACOT7	Open sea	-0.00702	0.00172	0.000067	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16034168	chr1:6336711	1	6336711	ACOT7	North shelf	0.00048	0.00012	0.000067	None	33450751_Mulder-RH_age_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	-0.0328987	0.0082521	0.00006732166	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.24086	0.0604194	0.00006732713	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00506442	chr1:6340054	1	6340054	ACOT7	Island	0.166264	0.0417123	0.00006747772	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0473568	0.0118814	0.00006758369	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-0.0333503	0.00836793	0.00006766889	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0377549	0.00947484	0.00006787548	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0340459	0.00855209	0.00006895583	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16064510	chr1:6412515	1	6412515	ACOT7	Open sea	0.0331654	0.00833155	0.00006904169	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0311951	0.00783882	0.00006937475	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.042283	0.0106252	0.00006939165	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.0545216	0.0137017	0.00006948823	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.0328348	0.00825212	0.00006955325	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0385537	0.00968959	0.00006957549	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02065192	chr1:6421414	1	6421414	ACOT7	Open sea	0.0328308	0.00825212	0.00006969307	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	-0.0328297	0.00825212	0.0000697317	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0342405	0.00860916	0.0000700613	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.24159	0.0607777	0.00007065544	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09273516	chr1:6454339	1	6454339	ACOT7	South shore	0.0328003	0.00825213	0.00007078572	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04309375	chr1:6363886	1	6363886	ACOT7	Open sea	0.0013	None	0.000071	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0327937	0.00825213	0.00007102446	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.0327918	0.00825213	0.00007109065	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0383331	0.00964705	0.00007114502	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0350805	0.00883073	0.00007144646	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0468698	0.0118081	0.0000724286	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080913	chr1:6328733	1	6328733	ACOT7	Open sea	0.0339483	0.00855641	0.00007295083	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05824903	chr1:6360355	1	6360355	ACOT7	Open sea	-0.0327358	0.00825215	0.00007314674	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11346669	chr1:6342159	1	6342159	ACOT7	South shore	-0.0045	0.0011	0.000074	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg10935026	chr1:6434560	1	6434560	ACOT7	Open sea	0.041	0.01031	0.000074	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PLXND1 protein levels (SeqId = 19561-216)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLXND1 protein levels (SeqId = 19561-216)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plexin-D1	774	1	Adults (18-65 years)	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.7	0.177	0.000074	None	Gadd-DA_plxnd1_protein_levels__seqid___19561-216__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	-0.0348241	0.0087857	0.0000741398	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23095988	chr1:6445804	1	6445804	ACOT7	Open sea	-0.0330002	0.00832581	0.00007417487	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.20128	0.0508058	0.00007468534	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0326875	0.00825216	0.00007496197	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0326862	0.00825216	0.00007501369	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	-0.0326803	0.00825216	0.00007523879	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.01	0.0026	0.000076	None	33450751_Mulder-RH_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	LAG3 protein levels (SeqId = 9950-229)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAG3 protein levels (SeqId = 9950-229)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte activation gene 3 protein	774	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	-1.09	0.276	0.000077	None	Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0326281	0.00825218	0.00007725394	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24599624	chr1:6378146	1	6378146	ACOT7	Open sea	-0.0326258	0.00825218	0.00007734467	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.0326177	0.00825218	0.00007766409	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0348753	0.00882436	0.0000778121	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PROC protein levels (SeqId = 2961-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PROC protein levels (SeqId = 2961-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vitamin K-dependent protein C	774	1	Adults (18-65 years)	Both	European	cg22346119	chr1:6453452	1	6453452	ACOT7	Island	-0.82	0.207	0.000078	None	Gadd-DA_proc_protein_levels__seqid___2961-1__somascan_protein_measurement
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg14879885	chr1:6341901	1	6341901	ACOT7	South shore	-2.07	0.52	0.000078	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	0.0326082	0.00825218	0.0000780396	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	0.0326029	0.00825218	0.00007824716	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	0.0420655	0.0106484	0.0000783847	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0348063	0.00881207	0.00007856775	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0334061	0.0084576	0.00007857331	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03499017	chr1:6445893	1	6445893	ACOT7	Open sea	-0.0370882	0.00939321	0.0000790428	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	-0.0365746	0.00927441	0.00008063844	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16293838	chr1:6330521	1	6330521	ACOT7	Open sea	-0.0517225	0.0131161	0.00008070154	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0394568	0.0100064	0.0000807939	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12576213	chr1:6374235	1	6374235	ACOT7	Open sea	0.0325388	0.0082522	0.00008082668	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	0.0338726	0.00859338	0.00008127985	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05786314	chr1:6452096	1	6452096	ACOT7	North shore	0.0401612	0.0101891	0.00008132484	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12740725	chr1:6342888	1	6342888	ACOT7	South shore	0.033795	0.00857462	0.00008142424	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13066938	chr1:6341140	1	6341140	ACOT7	Island	0.0341163	0.0086596	0.00008195702	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0404724	0.010273	0.00008196757	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0466029	0.0118301	0.00008208015	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15724772	chr1:6373534	1	6373534	ACOT7	Open sea	0.0324982	0.00825221	0.00008250076	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0395119	0.0100334	0.00008253363	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0466024	0.0118347	0.00008262656	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0337773	0.00857989	0.00008295685	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15529056	chr1:6417482	1	6417482	ACOT7	Open sea	-0.0335192	0.00851727	0.00008343001	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	-1.94	0.489	0.000084	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09513469	chr1:6421502	1	6421502	ACOT7	Open sea	-0.0324593	0.00825222	0.00008413548	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06407172	chr1:6445916	1	6445916	ACOT7	Open sea	0.0324581	0.00825222	0.00008418966	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0324485	0.00825222	0.00008459684	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg08389628	chr1:6388849	1	6388849	ACOT7	Open sea	0.028	0.00713	0.000085	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0324366	0.00825223	0.00008510428	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05912063	chr1:6419081	1	6419081	ACOT7	Open sea	0.034397	0.00875236	0.00008532766	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	0.0324182	0.00825223	0.0000858986	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMB4 protein levels (SeqId = 18340-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMB4 protein levels (SeqId = 18340-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit beta type-4	774	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-1.18	0.301	0.000086	None	Gadd-DA_psmb4_protein_levels__seqid___18340-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLPI protein levels (SeqId = 4413-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLPI protein levels (SeqId = 4413-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Antileukoproteinase	774	1	Adults (18-65 years)	Both	European	cg24698846	chr1:6406803	1	6406803	ACOT7	Open sea	-0.87	0.223	0.000086	None	Gadd-DA_slpi_protein_levels__seqid___4413-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26048493	chr1:6354272	1	6354272	ACOT7	Open sea	-0.0464321	0.0118222	0.00008621379	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12082302	chr1:6421246	1	6421246	ACOT7	Open sea	0.0324094	0.00825223	0.00008627913	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	0.0039	0.001	0.000087	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0467531	0.0119132	0.00008731898	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16306654	chr1:6419767	1	6419767	ACOT7	Open sea	0.0394004	0.0100415	0.00008757445	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24599624	chr1:6378146	1	6378146	ACOT7	Open sea	-0.032217	0.008213	0.00008796546	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17429065	chr1:6453910	1	6453910	ACOT7	Island	0.0422124	0.010763	0.00008821473	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.136099	0.0347089	0.00008846875	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.0323524	0.00825225	0.00008879183	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	0.0350535	0.00894199	0.0000889135	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0323491	0.00825225	0.00008893691	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SPOCK3 protein levels (SeqId = 9906-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPOCK3 protein levels (SeqId = 9906-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Testican-3	774	1	Adults (18-65 years)	Both	European	cg23230478	chr1:6360620	1	6360620	ACOT7	Open sea	-0.53	0.134	0.000089	None	Gadd-DA_spock3_protein_levels__seqid___9906-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	-0.0333044	0.00849652	0.00008903772	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11699125	chr1:6341327	1	6341327	ACOT7	Island	-0.0323465	0.00825225	0.00008905545	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09533740	chr1:6351416	1	6351416	ACOT7	Open sea	-0.0323421	0.00825225	0.00008925237	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.0323366	0.00825225	0.0000895007	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10859280	chr1:6419094	1	6419094	ACOT7	Open sea	-0.113638	0.0290136	0.00009011249	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19056927	chr1:6445909	1	6445909	ACOT7	Open sea	0.150155	0.0383474	0.00009051275	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10976772	chr1:6390595	1	6390595	ACOT7	Open sea	0.034101	0.00871108	0.00009093802	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	0.04093	0.0104556	0.00009095224	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	APOA1 protein levels (SeqId = 2750-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOA1 protein levels (SeqId = 2750-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein A-I	774	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-1.18	0.301	0.000091	None	Gadd-DA_apoa1_protein_levels__seqid___2750-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	0.0324935	0.00830228	0.00009126421	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05045598	chr1:6418521	1	6418521	ACOT7	Open sea	-0.0367274	0.00938622	0.00009160437	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	-0.0447742	0.0114453	0.00009193965	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14992217	chr1:6363562	1	6363562	ACOT7	Open sea	0.0081	0.0021	0.000092	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27090679	chr1:6420963	1	6420963	ACOT7	Open sea	0.0322772	0.00825227	0.00009220986	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08611694	chr1:6419112	1	6419112	ACOT7	Open sea	0.0362	0.00925854	0.00009274774	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18324862	chr1:6328955	1	6328955	ACOT7	Open sea	0.0316358	0.00809189	0.00009287866	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08937813	chr1:6334700	1	6334700	ACOT7	Open sea	-0.0322544	0.00825228	0.00009326934	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27029120	chr1:6454543	1	6454543	ACOT7	South shore	0.032243	0.00825228	0.00009380427	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (south asians)	Supplementary Table 4	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (south asians)	162	1	Adults (18-65 years)	Females	South Asian	cg23780021	chr1:6413795	1	6413795	ACOT7	Open sea	0.083098326	0.020649842	0.0000939	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(south_asians)
Gadd DA	Generation Scotland	35945220	31/07/2022	EPO protein levels (SeqId = 5813-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPO protein levels (SeqId = 5813-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Erythropoietin	774	1	Adults (18-65 years)	Both	European	cg10219223	chr1:6420713	1	6420713	ACOT7	Open sea	1.07	0.273	0.000094	None	Gadd-DA_epo_protein_levels__seqid___5813-58__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00821310	chr1:6420733	1	6420733	ACOT7	Open sea	-0.0322383	0.00825228	0.00009402424	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10375954	chr1:6419608	1	6419608	ACOT7	Open sea	-0.0322322	0.00825228	0.0000943134	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21156684	chr1:6411612	1	6411612	ACOT7	Open sea	-0.150616	0.0385787	0.00009490704	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10163234	chr1:6445901	1	6445901	ACOT7	Open sea	0.0322189	0.00825228	0.0000949464	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	-0.0322171	0.00825229	0.00009502858	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25029657	chr1:6355008	1	6355008	ACOT7	Open sea	-0.0322012	0.00825229	0.00009579268	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04179431	chr1:6419108	1	6419108	ACOT7	Open sea	-0.165147	0.0423262	0.00009585462	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg25345603	chr1:6450174	1	6450174	ACOT7	North shelf	-1.6	0.418	0.000096	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07514368	chr1:6382250	1	6382250	ACOT7	Open sea	0.0321965	0.00825229	0.0000960158	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02641839	chr1:6420826	1	6420826	ACOT7	Open sea	-0.0321959	0.00825229	0.00009604428	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26976553	chr1:6418944	1	6418944	ACOT7	Open sea	-0.0321929	0.00825229	0.00009618805	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21220721	chr1:6341230	1	6341230	ACOT7	Island	-0.0321461	0.0082523	0.00009847031	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25855436	chr1:6445975	1	6445975	ACOT7	Open sea	0.0321318	0.00825231	0.00009917595	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02568911	chr1:6453807	1	6453807	ACOT7	Island	0.0319214	0.0081984	0.00009920231	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25931201	chr1:6350405	1	6350405	ACOT7	Open sea	0.0323983	0.00832261	0.00009952764	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09887323	chr1:6348460	1	6348460	ACOT7	Open sea	0.0343546	0.00882675	0.00009982113	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3