author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0085 0.00034 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.02 0.0019 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0068 0.00026 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10894512 chr10:90712478 10 90712478 ACTA2 Open sea 0.53211 0.00771 5.399999999999999e-138 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09990481 chr10:90712684 10 90712684 ACTA2 Open sea 0.3848 0.00565 6.399999999999999e-137 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03221266 chr10:90712732 10 90712732 ACTA2 Open sea 0.45781 0.00751 4.9e-128 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19015961 chr10:90712748 10 90712748 ACTA2 Open sea 0.33144 0.00578 4.1e-123 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.29858 0.00539 1.7e-120 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07436807 chr10:90712767 10 90712767 ACTA2 Open sea 0.25466 0.00651 9.9e-94 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07216529 chr10:90712739 10 90712739 ACTA2 Open sea 0.21715 0.0057 1.0999999999999999e-91 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea - - 1.81e-88 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26479099 chr10:90712948 10 90712948 ACTA2 Open sea 0.06762 0.00246 1.6e-68 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.139198 0.00817619 2.2309399999999997e-64 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea - - 2.25e-55 - 28056824_age_4_vs_age_0 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 3.12576 0.10711 1.0399999999999999e-46 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.110978 0.00820557 1.980285e-41 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.0049 None 2.7e-37 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg15940800 chr10:90725603 10 90725603 ACTA2 Open sea - - 1.6800000000000002e-35 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea - - 2.73e-34 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0939614 0.00822004 3.936642e-30 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0828159 0.00822821 9.433325e-24 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0788382 0.00823087 1.1410109999999999e-21 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.08144 0.00767 4.7e-21 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 3.4 0.388 5.7e-18 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0702509 0.00823617 1.611201e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0692089 0.00823677 4.7711860000000007e-17 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10894512 chr10:90712478 10 90712478 ACTA2 Open sea -0.00066 0.000082 6.7e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.28568 0.0354766 8.626147e-16 None 39706196_Hannah-M.-Smith_bmi_discovery Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3299504 (gene symbol: ACTA2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3299504 (gene symbol: ACTA2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea None None 0.000000000000014 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3299504__gene_symbol__acta2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0634086 0.00823996 0.00000000000001501779 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.056 0.00739 0.000000000000032 None Robert-F-Hillary_Incident_COPD_Basic_model Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0142 0.00190518 0.0000000000000455 - 28811542_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.267958 0.0355661 0.00000000000005159901 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0601714 0.00824161 0.0000000000003004821 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10211081 chr10:90713603 10 90713603 ACTA2 Open sea -0.0012 0.00017 0.00000000000091 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0574858 0.00824292 0.000000000003212998 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.024 0.0031 0.000000000014 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0551643 0.008244 0.00000000002289844 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0548493 0.00824414 0.00000000002971133 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0545878 0.00824426 0.00000000003684028 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0539535 0.00824455 0.00000000006182209 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0073 0.00112 0.000000000072 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.053485 0.00824475 0.00000000009027205 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.047 0.00727 0.0000000001 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0531284 0.00824491 0.0000000001201723 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.228043 0.035473 0.000000000132123 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.052132 0.00824534 0.0000000002646349 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.052046 0.00825224 0.000000000292844 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0514208 0.00824565 0.0000000004608698 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea -0.0519744 0.00834696 0.0000000004891953 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0692915 0.0111304 0.0000000004932763 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0513216 0.00824569 0.0000000004976423 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10211081 chr10:90713603 10 90713603 ACTA2 Open sea 0.0012 None 0.00000000063 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea -0.0510013 0.00824583 0.000000000637083 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.050987 0.00824583 0.0000000006441419 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.068448 0.0111752 0.0000000009301832 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -1.7 0.277 0.0000000012 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0498354 0.00824631 0.000000001545985 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0497718 0.00824634 0.000000001621588 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07436807 chr10:90712767 10 90712767 ACTA2 Open sea -0.00051 0.000086 0.0000000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0493954 0.00824649 0.000000002149144 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0488288 0.00824672 0.000000003271443 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0487819 0.00824674 0.000000003386524 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0484829 0.00824686 0.000000004218543 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.199546 0.0339856 0.000000004393887 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.048014 0.00824705 0.000000005937784 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0477367 0.00824716 0.000000007257381 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0476619 0.00825644 0.000000007959582 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.047682 0.00826897 0.000000008262337 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 2.4 0.413 0.0000000083 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0474687 0.00824726 0.000000008801305 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15940800 chr10:90725603 10 90725603 ACTA2 Open sea -0.00071 0.00012 0.00000001 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.01 0.0018 0.000000012 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0638763 0.0112585 0.00000001424497 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.046341 0.00819604 0.00000001596138 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0465155 0.00824763 0.00000001733332 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.210025 0.0373379 0.00000001883904 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26479099 chr10:90712948 10 90712948 ACTA2 Open sea 0.00085 None 0.000000022 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0620838 0.0111258 0.00000002445674 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg10894512 chr10:90712478 10 90712478 ACTA2 Open sea -0.01056 0.0019 0.0000000272 - 23334450_rheumatoid_arthritis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea -0.0954832 0.0171918 0.0000000283349 None 39706196_Hannah-M.-Smith_bmi_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea - - 0.0000000326 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0455206 0.00824801 0.00000003467505 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0448015 0.00824828 0.00000005673642 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0444963 0.00824839 0.00000006976487 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0444923 0.0082484 0.00000006995075 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0442636 0.00824848 0.00000008160234 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0441188 0.00824853 0.00000008992368 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07216529 chr10:90712739 10 90712739 ACTA2 Open sea 0.00052 None 0.000000099 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0438579 0.00823612 0.0000001024068 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0435243 0.00824875 0.0000001335662 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0431842 0.00824887 0.0000001671135 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0431031 0.0082489 0.0000001762387 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.04295 0.00824895 0.0000001947998 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0428767 0.00824898 0.0000002043478 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0094 0.0018 0.00000021 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0578953 0.0111628 0.0000002172029 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0427597 0.00824902 0.0000002205208 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.0427187 0.00824903 0.0000002264801 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.0425844 0.00824908 0.0000002470924 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0426149 0.00826736 0.0000002574742 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.031 0.00603 0.00000026 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0423747 0.00828135 0.0000003145516 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.042131 0.00824924 0.00000033096 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.0421043 0.0082497 0.0000003371671 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.042093 0.00824925 0.0000003391153 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -1.8 0.356 0.00000042 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0417253 0.00824938 0.0000004287976 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0418419 0.00827879 0.0000004376153 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea -0.180425 0.0357777 0.0000004628417 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.18703 0.0371041 0.0000004685285 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0415578 0.00824944 0.0000004768808 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0415068 0.00824946 0.0000004925064 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 African ancestry Table S6 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 Whole blood - 2423 3 56 Both African cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -6.33e-05 1.26e-05 0.000000508 - 27843151_alcohol_consumption_per_day_african_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0413996 0.00824949 0.0000005270289 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.214262 0.0433688 0.0000007866584 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0399783 0.00811623 0.0000008496677 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.0421825 0.00861253 0.0000009794501 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0403705 0.00824984 0.000001001138 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0548975 0.0112477 0.000001067696 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.040242 0.00824988 0.000001083504 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0402428 0.00826574 0.000001135457 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0400757 0.00824994 0.000001199855 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0400057 0.00824996 0.000001252324 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.150628 0.0310863 0.000001274097 None 39706196_Hannah-M.-Smith_bmi_discovery Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg10245319 chr10:90728242 10 90728242 ACTA2 Open sea 0.142139 0.0294443 0.000001383 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0398289 0.00828672 0.000001552318 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15950761 chr10:90739926 10 90739926 ACTA2 Open sea -0.00039 0.00008 0.0000016 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.167379 0.0349058 0.000001638845 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0394264 0.00825015 0.000001779962 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CRTAM protein levels (SeqId = 7968-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRTAM protein levels (SeqId = 7968-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytotoxic and regulatory T-cell molecule 774 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.8 0.167 0.0000019 None Gadd-DA_crtam_protein_levels__seqid___7968-15__somascan_protein_measurement Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea None None 0.0000021 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea -0.0378597 0.00798585 0.000002148299 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0391438 0.00825992 0.000002167827 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0390735 0.00825027 0.000002199884 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.00055 0.00012 0.0000023 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0389112 0.00825032 0.000002423503 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0388272 0.00825035 0.000002547758 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0524815 0.0111701 0.00000264623 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea -0.0386621 0.0082504 0.000002809731 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0386396 0.00825041 0.000002847367 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0386047 0.00825042 0.000002906817 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.16228 0.0347671 0.000003068625 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0385084 0.00825045 0.000003076927 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.049729 0.0106735 0.000003203484 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0523867 0.0112505 0.000003246038 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0522486 0.0112422 0.000003388659 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0382453 0.00825053 0.000003591603 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0382435 0.00825053 0.0000035953 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0511717 0.0110519 0.000003685498 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0381301 0.00825057 0.000003841913 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Agha G CHARGE 31424985 2019-08-19 Myocardial infarction EFO_0000612 Meta analysis Table 2 Myocardial infarction DNA methylation Age, sex, body mass index, smoking, education, cell composition (reference based), ancestry (other), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 10923 8 Adults Both European cg07436807 chr10:90712767 10 90712767 ACTA2 Open sea -0.78 0.169 0.0000041 None 31424985_Agha-G_myocardial_infarction_meta_analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0379442 0.00827096 0.000004520016 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0377033 0.00822661 0.000004619432 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0377782 0.00825068 0.000004714909 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.0376631 0.00825071 0.000005039725 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0376501 0.00825072 0.000005077504 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.0375401 0.00823833 0.000005236598 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0375909 0.00825074 0.000005254132 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0504546 0.0110748 0.000005260269 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0375353 0.00825075 0.000005425094 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.1380261 0.0303538 0.000005435 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Gadd DA Generation Scotland 35945220 31/07/2022 GZMK protein levels (SeqId = 9545-156) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMK protein levels (SeqId = 9545-156) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme K 774 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.76 0.167 0.0000059 None Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0373579 0.00825081 0.000006007298 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0025 0.00053 0.0000062 None 33564054_Kashima-K_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10211081 chr10:90713603 10 90713603 ACTA2 Open sea 0.0073 0.0016 0.0000063 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.050611 0.0112053 0.000006330205 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0371434 0.00823767 0.000006564668 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.0371804 0.00825086 0.000006649532 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0371396 0.00825088 0.000006806044 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0370636 0.00825423 0.00000716787 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0502586 0.0111974 0.000007229585 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0369627 0.00825093 0.000007527059 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea -0.036945 0.00825093 0.000007602896 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0369442 0.00825093 0.000007606635 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.037481 0.00837821 0.000007747953 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0368281 0.00825097 0.000008123682 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea -0.0368854 0.00827003 0.000008251855 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0364105 0.0082511 0.0000102768 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0362566 0.00825114 0.0000111997 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0492243 0.0112219 0.0000116026 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0482655 0.0111641 0.00001547515 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea -0.0356368 0.00824383 0.00001550485 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 CD4+ T-cells Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 CD4+ T-cells - 60 1 46.5 Males European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.267667 0.062 0.0000156 None 27105112_hiv_infection_cd4_tcells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.0355512 0.00822826 0.00001566157 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0356091 0.00825134 0.00001602435 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.00059542 0.00013746 0.0000162 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0484311 0.0112343 0.00001635762 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0355294 0.00825516 0.00001689056 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0354636 0.00826352 0.00001785401 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.048206 0.0112332 0.00001787071 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg10211081 chr10:90713603 10 90713603 ACTA2 Open sea -1.014657 0.237 0.0000185 - 27105112_hiv_infection_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.129239 0.0302521 0.00001946483 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0352011 0.00825145 0.0000200208 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0352735 0.00827608 0.00002037763 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09822170 chr10:90734584 10 90734584 ACTA2 Open sea 0.035146 0.00826024 0.00002104955 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.184418 0.0434106 0.00002165896 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg09990481 chr10:90712684 10 90712684 ACTA2 Open sea -0.171899 0.0405663 0.00002271543 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0004919 0.00011567 0.000023 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.034937 0.00825153 0.00002309624 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0349673 0.00826105 0.00002322073 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.034919 0.00825154 0.00002332181 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0349185 0.00825154 0.00002332828 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.155129 0.0367345 0.00002423382 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0348057 0.00825157 0.00002478874 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26479099 chr10:90712948 10 90712948 ACTA2 Open sea -0.00051 0.00012 0.000025 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.026 0.00618 0.000026 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0346667 0.00825161 0.0000267061 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15950761 chr10:90739926 10 90739926 ACTA2 Open sea -0.007 0.00163 0.000027 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0468643 0.0111694 0.00002735441 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.01 0.00242 0.000029 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0471125 0.0112651 0.0000290409 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0469138 0.0112416 0.00003020616 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Lung Cancer None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Lung Cancer Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18364 1 Adults (18-65y) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.016 0.00395 0.000031 None Robert-F-Hillary_Incident_Lung_Cancer_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07216529 chr10:90712739 10 90712739 ACTA2 Open sea -0.00031 0.000074 0.000032 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0998468 0.0240226 0.00003234 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.152599 0.0367065 0.00003236019 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.046574 0.0112054 0.00003251317 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea -0.0347549 0.00837372 0.00003336714 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Battram T ARIES None 2020-08-20 Weight EFO_0004338 None None DNA methylation Weight Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values kg Illumina HumanMethylation450 Whole blood None 714 1 Adults Females European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.0084 0.00202 0.000035 None Battram-T_weight Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.0461556 0.0111881 0.00003721261 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0340219 0.00825179 0.00003760817 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0340826 0.00828812 0.00003939987 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0339659 0.00828078 0.00004122046 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea 0.0337636 0.00825186 0.00004306293 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0332805 0.008186 0.00004817233 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09248698 chr10:90722382 10 90722382 ACTA2 Open sea 0.0390473 0.00961341 0.0000489585 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0333712 0.00828209 0.0000562213 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0332476 0.00825201 0.00005629025 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0332979 0.00826929 0.00005685188 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.0330385 0.00822452 0.00005922048 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea None None 0.00006 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0330456 0.00825206 0.00006244862 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10211081 chr10:90713603 10 90713603 ACTA2 Open sea 0.0037 None 0.000063 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0329883 0.00825208 0.00006430925 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea -0.0329202 0.0082521 0.00006658817 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09248698 chr10:90722382 10 90722382 ACTA2 Open sea 0.0337433 0.00846177 0.00006702953 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09990481 chr10:90712684 10 90712684 ACTA2 Open sea 0.0327043 0.00821293 0.00006865409 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0439807 0.0110476 0.00006894858 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0328103 0.00825213 0.00007042582 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09248698 chr10:90722382 10 90722382 ACTA2 Open sea 0.0336273 0.00845941 0.00007067703 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea -0.0327967 0.00825213 0.00007091589 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea None None 0.000073 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0319834 0.00806737 0.00007388516 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.0445638 0.0112423 0.00007406943 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.044022 0.0111362 0.0000775203 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19335412 chr10:90694875 10 90694875 ACTA2 Open sea -0.0443407 0.0112262 0.00007859862 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17133119 chr10:90746801 10 90746801 ACTA2 North shelf 0.0325514 0.0082522 0.00008031451 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.032994 0.00836867 0.00008098979 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Battram T ARIES None 2020-08-20 Total body mass EFO_0004338 None None DNA methylation Total body mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 704 1 Adults Females European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.0000082 0.0000021 0.000086 None Battram-T_total_body_mass Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.043712 0.0111552 0.00008949237 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0436868 0.0111534 0.00009009615 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0323071 0.00825226 0.00009083501 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0322791 0.00825227 0.00009212366 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27571617 chr10:90728300 10 90728300 ACTA2 Open sea 0.03227 0.00825227 0.0000925439 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0323351 0.00827054 0.00009283819 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0322614 0.00825227 0.00009294192 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea -0.0438336 0.0112174 0.00009361367 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Battram T ARIES None 2020-08-20 Total tissue mass None None None DNA methylation Total tissue mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 704 1 Adults Females European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.0000083 0.0000021 0.000095 None Battram-T_total_tissue_mass Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00551526 chr10:90739149 10 90739149 ACTA2 Open sea 0.032216 0.00825229 0.0000950848 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17967429 chr10:90711500 10 90711500 ACTA2 Open sea 0.0331202 0.00849517 0.00009713709 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.0321594 0.0082523 0.00009781772 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea 0.043559 0.0111781 0.00009790396 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02169357 chr10:90720523 10 90720523 ACTA2 Open sea -0.050971 0.0130847 0.000098453 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_4 Battram T ARIES None 2020-08-20 Gynoid total mass EFO_0004338 None None DNA methylation Gynoid total mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 705 1 Adults Females European cg03755566 chr10:90695563 10 90695563 ACTA2 Open sea 0.000052 0.000013 0.000099 None Battram-T_gynoid_total_mass