author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.0016	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0018	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0071	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.021	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0022	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0024	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.13033	0.00415	9.9e-78	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.2637	0.01079	5.3e-61	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.126119	0.00819064	4.396175e-53	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.112688	0.00820398	1.137712e-42	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.04115	0.00239	5.9e-41	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0928907	0.00822087	1.7494730000000002e-29	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	-	-	2.97e-29	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0921346	0.00822145	4.9648320000000004e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0517	0.00398	3.8000000000000005e-28	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0869737	0.00822528	4.883657e-26	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0022	None	7.599999999999999e-24	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0818599	0.00822886	3.0514150000000005e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0749951	0.00823332	9.394741999999999e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0718224	0.00823525	3.041102e-18	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	0.01887	0.00196	4.1e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	None	None	0.000000000000017	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3945651__gene_symbol__apobec3g__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0631541	0.00824009	0.00000000000001911213	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0629945	0.00824017	0.00000000000002222191	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0616981	0.00824084	0.00000000000007454496	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0614918	0.00824095	0.00000000000009017624	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0605707	0.00824141	0.0000000000002093551	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0014	None	0.00000000000054	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0593659	0.00824201	0.0000000000006184172	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0583912	0.00824248	0.000000000001462407	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0577328	0.0082428	0.000000000002595333	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.055862	0.00824368	0.00000000001279518	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.041	0.00539	0.000000000013	None	32795589_Kyung-WK_eosinophilia_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	None	None	0.000000000043	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3945651__gene_symbol__apobec3g__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.04156	0.00596	0.000000000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0539847	0.00824453	0.000000000060274	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.053837	0.0082446	0.00000000006794793	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0537271	0.00824465	0.00000000007426249	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3945651 (gene symbol: APOBEC3G)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	None	None	0.000000000083	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3945651__gene_symbol__apobec3g__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0530941	0.00824493	0.0000000001235093	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0525102	0.00824518	0.0000000001964588	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.051869	0.00824546	0.0000000003251905	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	random effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.87	0.139	0.00000000048	None	33646943_Hannon-E_schizophrenia_random_effects_meta-analysis
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	fixed effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.87	0.139	0.00000000048	None	33646943_Hannon-E_schizophrenia_fixed_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0513573	0.00824568	0.0000000004841176	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0512954	0.0082457	0.0000000005078578	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0511738	0.00824575	0.0000000005578364	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0508962	0.00824587	0.0000000006906166	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0506658	0.00824597	0.0000000008238652	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0499421	0.00824627	0.000000001426635	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.0009	None	0.0000000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0489825	0.00824666	0.000000002920435	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-1.7	0.29	0.0000000031	4807	31197173_Liu-J_fasting_glucose_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0469911	0.00824745	0.00000001238	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0468086	0.00824752	0.00000001409174	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0461238	0.00824778	0.0000000228127	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0460319	0.00824782	0.00000002432373	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0459847	0.00824784	0.00000002513722	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0493322	0.00891471	0.0000000318737	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.230422	0.041837	0.00000003689327	None	39706196_Hannah-M.-Smith_bmi_discovery
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-1.62	0.3	0.000000046	4807	31197173_Liu-J_fasting_glucose_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0450666	0.00824818	0.00000004735935	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0448273	0.00824827	0.0000000557484	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0438832	0.00824862	0.0000001052508	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0432775	0.00824884	0.0000001571751	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.282576	0.0547988	0.0000002542338	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0414645	0.00811625	0.0000003282455	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0420354	0.00824927	0.0000003518784	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0412875	0.00824953	0.0000005655876	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0444792	0.00890856	0.0000006017564	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0408346	0.00824968	0.0000007509784	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0408213	0.00824969	0.0000007572433	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.292974	0.0596578	0.0000009144039	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in medium LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.022	0.0044	0.000001	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_medium_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0586978	0.0120064	0.000001024979	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	-0.0401236	0.00824992	0.000001165173	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	0.138275	0.0284998	0.000001233574	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0399826	0.00824997	0.00000127013	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in medium LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.053	0.0108	0.0000013	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_medium_ldl
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0023	0.00045	0.0000013	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0636106	0.0131734	0.00000138798	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in small LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	679	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.058	0.0118	0.0000014	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_small_ldl
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	-0.139144	0.0292753	0.000002020716	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0391985	0.00825023	0.000002041311	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0390479	0.00825027	0.000002233743	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.038974	0.0082503	0.000002334524	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in small LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.0199	0.0042	0.0000027	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_small_ldl
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	-0.136127	0.0292092	0.000003179256	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0384202	0.00825048	0.000003240958	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in small LDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	679	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.031	0.0067	0.000004	None	Battram-T_phospholipids_to_total_lipids_ratio_in_small_ldl
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.00449	0.00098	0.0000042	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0378185	0.00825066	0.000004606074	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	-0.0378901	0.00833375	0.000005495854	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PILRA protein levels (SeqId = 10816-150)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PILRA protein levels (SeqId = 10816-150)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Paired immunoglobulin-like type 2 receptor alpha	774	1	Adults (18-65 years)	Both	European	cg09357205	chr22:39491903	22	39491903	APOBEC3H	Open sea	-1.29	0.284	0.0000055	None	Gadd-DA_pilra_protein_levels__seqid___10816-150__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-1.4	0.315	0.0000066	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0531092	0.0117939	0.000006748996	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.037094	0.00825089	0.00000698542	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0370773	0.00825089	0.000007052104	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0400196	0.00890742	0.000007081592	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0369215	0.00825094	0.000007704918	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08999478	chr22:39492065	22	39492065	APOBEC3H	Open sea	-0.0368752	0.00825096	0.000007909808	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-	-	0.0000081	-	26500701_sex_kora_f4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.230679	0.0517409	0.000008310794	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0367607	0.00825099	0.000008439473	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.245613	0.0551649	0.000008546848	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.186746	0.0419456	0.000008556319	None	39706196_Hannah-M.-Smith_body_fat_discovery
Battram T	ARIES	None	2020-08-20	LDL cholesterol	EFO_0004195	fasting	None	DNA methylation	LDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	692	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.144	0.032	0.0000091	None	Battram-T_ldl_cholesterol_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0561023	0.0127477	0.00001085325	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in medium LDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.038	0.0085	0.000012	None	Battram-T_phospholipids_to_total_lipids_ratio_in_medium_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0360335	0.00825121	0.0000126796	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0360312	0.00825121	0.00001269595	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in large LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.039	0.0089	0.000014	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0358491	0.00825126	0.00001404203	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0358196	0.00825127	0.00001427172	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.031	0.00728	0.000016	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	GIP protein levels (SeqId = 16292-288)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GIP protein levels (SeqId = 16292-288)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gastric inhibitory polypeptide	774	1	Adults (18-65 years)	Both	European	cg09357205	chr22:39491903	22	39491903	APOBEC3H	Open sea	-1.27	0.295	0.000016	None	Gadd-DA_gip_protein_levels__seqid___16292-288__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08999478	chr22:39492065	22	39492065	APOBEC3H	Open sea	0.0356081	0.00825134	0.00001603333	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0355949	0.00825134	0.00001614932	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0355705	0.00825135	0.00001636744	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	0.0355699	0.00825135	0.00001637235	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.035322	0.00821063	0.00001703729	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.035445	0.00825138	0.00001753072	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0514854	0.0120158	0.00001840572	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0501461	0.0117731	0.00002062762	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0350701	0.00825149	0.00002149413	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters in small LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	1.36	0.32	0.000022	None	Battram-T_cholesterol_esters_in_small_ldl
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in small LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.026	0.006	0.000022	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_small_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0350045	0.00825151	0.00002227035	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol in medium LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.69	0.161	0.000023	None	Battram-T_total_cholesterol_in_medium_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	-0.0508466	0.0120308	0.00002389188	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Total lipids in medium LDL	EFO_0004529	None	None	DNA methylation	Total lipids in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.52	0.121	0.000024	None	Battram-T_total_lipids_in_medium_ldl
Battram T	ARIES	None	2020-08-20	Cholesterol esters in medium LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.84	0.2	0.000024	None	Battram-T_cholesterol_esters_in_medium_ldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in small LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	1.12	0.26	0.000025	None	Battram-T_total_cholesterol_in_small_ldl
Battram T	ARIES	None	2020-08-20	Total lipids in small LDL	EFO_0004529	None	None	DNA methylation	Total lipids in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.83	0.2	0.000027	None	Battram-T_total_lipids_in_small_ldl
Battram T	ARIES	None	2020-08-20	Phospholipids in large LDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	1.55	0.37	0.000032	None	Battram-T_phospholipids_in_large_ldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.21	0.051	0.000033	None	Battram-T_total_cholesterol_in_ldl
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.033	0.00786	0.000033	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26124861	chr22:39496944	22	39496944	APOBEC3H	Open sea	0.0343778	0.00828655	0.00003363558	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0486456	0.0117421	0.00003449502	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Concentration of medium LDL particles	EFO_0004611	None	None	DNA methylation	Concentration of medium LDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	None	None	0.000036	None	Battram-T_concentration_of_medium_ldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26124861	chr22:39496944	22	39496944	APOBEC3H	Open sea	0.0342365	0.00829035	0.00003652781	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in medium LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.028	0.0067	0.000038	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_ldl
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	1.2	0.294	0.000039	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.213142	0.0518638	0.00003980963	None	39706196_Hannah-M.-Smith_body_fat_discovery
Battram T	ARIES	None	2020-08-20	Total lipids in large LDL	EFO_0004529	None	None	DNA methylation	Total lipids in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.32	0.076	0.000041	None	Battram-T_total_lipids_in_large_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.03381	0.00825185	0.00004203103	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0337684	0.00825186	0.00004295674	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Neumann A	ALSPAC, GENR, INMA, NEST, PREDO	33184255	2020-11-12	ADHD	EFO_0003888	At birth	Supplementary data adhd_birth_results	ADHD	DNA methylation	maternal age, education level, smoking, gestational age, sex, cell composition (reference based)	ADHD score	Beta Values	Illumina HumanMethylation450	Cord Blood	None	2477	5	Infants	Both	European, African	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-2.569	0.612	0.000043	None	33184255_Neumann-A_adhd_at_birth
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0046	0.0011	0.000043	-	27651444_smoking_current_vs_never_smoking
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large LDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.56	0.137	0.000044	None	Battram-T_cholesterol_esters_in_large_ldl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.00087	None	0.000044	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CNPY3 protein levels (SeqId = 17327-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNPY3 protein levels (SeqId = 17327-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein canopy homolog 3	774	1	Adults (18-65 years)	Both	European	cg09357205	chr22:39491903	22	39491903	APOBEC3H	Open sea	-1.2	0.295	0.000049	None	Gadd-DA_cnpy3_protein_levels__seqid___17327-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0334781	0.00825194	0.00004996467	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol in large LDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	0.43	0.105	0.00005	None	Battram-T_total_cholesterol_in_large_ldl
Battram T	ARIES	None	2020-08-20	Phospholipids in medium LDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	2.5	0.62	0.000055	None	Battram-T_phospholipids_in_medium_ldl
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.299678	0.0743	0.000055	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0481499	0.0119581	0.0000568879	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in large LDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	-0.069	0.017	0.000058	None	Battram-T_phospholipids_to_total_lipids_ratio_in_large_ldl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24515575	chr22:39492303	22	39492303	APOBEC3H	Open sea	0.003	0.00074	0.00006	None	33450751_Mulder-RH_sex_discovery
Battram T	ARIES	None	2020-08-20	Concentration of small LDL particles	EFO_0004611	None	None	DNA methylation	Concentration of small LDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	None	None	0.000064	None	Battram-T_concentration_of_small_ldl_particles
Battram T	ARIES	None	2020-08-20	Concentration of large LDL particles	EFO_0004611	None	None	DNA methylation	Concentration of large LDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	None	None	0.000065	None	Battram-T_concentration_of_large_ldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0327204	0.00825215	0.00007371956	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol in medium LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	3.6	0.91	0.000078	None	Battram-T_free_cholesterol_in_medium_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	-0.0326019	0.00825218	0.00007828676	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18696237	chr22:39491975	22	39491975	APOBEC3H	Open sea	0.0325969	0.00825218	0.00007848766	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09135399	chr22:39493114	22	39493114	APOBEC3H	Open sea	0.0328677	0.00835085	0.00008328606	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	-0.0324658	0.00825222	0.00008386159	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17972162	chr22:39496387	22	39496387	APOBEC3H	Open sea	0.0349402	0.00889996	0.00008680506	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Phospholipids in small LDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	3.8	0.97	0.000087	None	Battram-T_phospholipids_in_small_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06229674	chr22:39492189	22	39492189	APOBEC3H	Open sea	0.0462423	0.0117854	0.00008759536	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Phospholipids in very small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	2.5	0.64	0.000092	None	Battram-T_phospholipids_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Free cholesterol in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03582215	chr22:39499750	22	39499750	APOBEC3H	Open sea	1.7	0.44	0.000092	None	Battram-T_free_cholesterol_in_large_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24424889	chr22:39494175	22	39494175	APOBEC3H	Open sea	-0.0321503	0.0082523	0.00009826386	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1