author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0017	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.012	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.149599	0.00816366	3.51126e-74	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.141899	0.00816841	6.320122e-67	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.143124	0.00824511	7.908961e-67	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.141607	0.00817337	1.389555e-66	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.140233	0.00819442	5.059759e-65	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.138152	0.00816467	1.270094e-63	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.138197	0.00817735	1.7923029999999997e-63	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.138611	0.00820405	1.937682e-63	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.136826	0.00819096	4.548575e-62	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.128329	0.00832827	3.731277e-53	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.125493	0.0081913	1.4285240000000002e-52	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.124896	0.00820779	6.82375e-52	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.123614	0.00823389	1.4361249999999999e-50	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.121973	0.00819492	9.65095e-50	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	-0.12974	0.00645	3.1999999999999996e-49	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.11545	0.00616	2.3e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	1.04	0.078	4.9e-40	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	1.19	0.091	6.2e-39	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	1.01	0.079	5.8e-38	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	1.17	0.091	2.1e-37	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	1	0.079	4e-37	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	1.16	0.091	4.4e-37	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0996856	0.00821545	1.012865e-33	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	1.35	0.113	6.400000000000001e-33	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	1.35	0.113	9.999999999999999e-33	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	1.33	0.113	7.500000000000001e-32	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.120382	0.0106367	1.4245860000000002e-29	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	1.25681	0.08145	1.2400000000000001e-26	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0879922	0.00822455	1.293438e-26	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	1.30155	0.09408	1.0799999999999999e-23	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0948578	0.00951159	2.377985e-23	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.04993	0.00454	4e-22	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	2.14	0.225	1.7e-21	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0784802	0.00823111	1.736804e-21	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	2.14	0.226	2.3e-21	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0903418	0.00952925	2.9123219999999998e-21	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0901687	0.00975263	2.656934e-20	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	2.07	0.225	3.6e-20	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGFRP3 protein levels (SeqId = 18899-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGFRP3 protein levels (SeqId = 18899-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor-related protein 3	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.7	0.079	7.7e-19	None	Gadd-DA_hdgfrp3_protein_levels__seqid___18899-82__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGFRP3 protein levels (SeqId = 18899-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGFRP3 protein levels (SeqId = 18899-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor-related protein 3	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.81	0.092	1.5e-18	None	Gadd-DA_hdgfrp3_protein_levels__seqid___18899-82__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0708108	0.00823585	8.932596e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0704781	0.00823604	1.2689440000000002e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.069617	0.00823654	3.124812e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0692908	0.00823673	4.383709e-17	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0743104	0.00895814	1.176635e-16	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0723277	0.00897738	8.44129e-16	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0656095	0.00823878	0.000000000000001794643	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGFRP3 protein levels (SeqId = 18899-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGFRP3 protein levels (SeqId = 18899-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor-related protein 3	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.9	0.114	0.0000000000000026	None	Gadd-DA_hdgfrp3_protein_levels__seqid___18899-82__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	-0.02134	0.00251	0.0000000000000048	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	-0.0082	0.0011	0.000000000000066	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.00095	None	0.000000000000095	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0606428	0.00824138	0.0000000000001960888	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0013	0.00019	0.00000000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0583236	0.00824252	0.000000000001551547	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.057791	0.00824277	0.000000000002467533	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF3 protein levels (SeqId = 4840-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF3 protein levels (SeqId = 4840-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulocyte colony-stimulating factor	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.551	0.079	0.0000000000031	None	Gadd-DA_csf3_protein_levels__seqid___4840-73__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF3 protein levels (SeqId = 4840-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF3 protein levels (SeqId = 4840-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulocyte colony-stimulating factor	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.638	0.092	0.0000000000035	None	Gadd-DA_csf3_protein_levels__seqid___4840-73__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0567713	0.00824326	0.000000000005929601	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0561682	0.00824354	0.00000000000988908	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0561456	0.00824355	0.0000000000100795	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF3 protein levels (SeqId = 4840-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF3 protein levels (SeqId = 4840-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulocyte colony-stimulating factor	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.762	0.113	0.000000000017	None	Gadd-DA_csf3_protein_levels__seqid___4840-73__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	1.65	0.245	0.000000000019	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0541955	0.00824444	0.00000000005077822	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0530218	0.00824496	0.0000000001308513	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.0024	None	0.00000000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0522543	0.00824529	0.0000000002403867	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.03	0.00422	0.00000000027	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0502045	0.00824616	0.000000001170149	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0495669	0.00824642	0.000000001890808	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0487032	0.00824677	0.000000003588591	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.048278	0.00824694	0.000000004899967	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Walker R	Generation Scotland	33397400	2021-01-04	APOE e2 vs e4	EFO_0007659	Meta-analysis	Table 1	DNA methylation	APOE e2 vs e4	age, sex, smoking, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3587	1	Adults	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	-0.053	0.0091	0.0000000058	Effect direction is relative to carriers of the e2 allele	33397400_Walker-R_apoe_e2_vs_e4_meta-analysis
Walker R	Generation Scotland	33397400	2021-01-04	APOE e2 vs e4	EFO_0007659	Meta-analysis	Table 1	DNA methylation	APOE e2 vs e4	age, sex, smoking, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3587	1	Adults	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.046	0.008	0.0000000058	Effect direction is relative to carriers of the e2 allele	33397400_Walker-R_apoe_e2_vs_e4_meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.01701	0.0028	0.0000000066	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0477312	0.00824716	0.000000007286275	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0473784	0.0082473	0.000000009389851	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	-0.0469354	0.00819242	0.00000001029305	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0472281	0.00824736	0.00000001045597	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	1.29	0.226	0.000000011	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	1.28	0.225	0.000000014	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGFRP3 protein levels (SeqId = 18899-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGFRP3 protein levels (SeqId = 18899-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor-related protein 3	774	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	1.29	0.227	0.000000015	None	Gadd-DA_hdgfrp3_protein_levels__seqid___18899-82__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	1.39	0.246	0.000000016	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0465627	0.00824762	0.00000001676655	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0465229	0.00824763	0.00000001724245	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	1.39	0.247	0.000000018	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	-0.0461727	0.00820843	0.00000001888751	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	1.25	0.226	0.000000031	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.045515	0.00824801	0.0000000348111	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	-0.0446154	0.00810391	0.00000003744774	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0452782	0.0082481	0.0000000409708	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0451126	0.00824817	0.00000004589263	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	-0.0443055	0.00824846	0.00000007933359	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0442146	0.0082485	0.00000008432929	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0438849	0.00824862	0.0000001051346	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.042839	0.00824899	0.0000002094268	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.230266	0.0453134	0.0000003780962	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.0021	None	0.00000041	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.0411447	0.00817369	0.0000004865683	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	-0.00055	0.00011	0.00000056	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0412244	0.00824955	0.0000005884768	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0409535	0.00824964	0.0000006973404	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0409279	0.00824965	0.0000007085573	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRTM4 protein levels (SeqId = 6572-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRTM4 protein levels (SeqId = 6572-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane neuronal protein 4	774	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.389	0.079	0.00000084	None	Gadd-DA_lrrtm4_protein_levels__seqid___6572-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.040373	0.00824984	0.0000009996235	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0402523	0.00824988	0.000001076706	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0741361	0.0152622	0.000001201118	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0399449	0.00824998	0.000001299672	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.0392691	0.00814624	0.000001446189	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.00077	0.00016	0.0000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 8971-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 8971-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1	774	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	1.19	0.248	0.0000016	None	Gadd-DA_nrxn1_protein_levels__seqid___8971-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0740424	0.0155086	0.000001820916	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.038239	0.00808621	0.000002278231	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRTM4 protein levels (SeqId = 6572-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRTM4 protein levels (SeqId = 6572-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane neuronal protein 4	774	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.433	0.092	0.0000023	None	Gadd-DA_lrrtm4_protein_levels__seqid___6572-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL26 protein levels (SeqId = 16760-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL26 protein levels (SeqId = 16760-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-26	774	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	1.17	0.249	0.0000025	None	Gadd-DA_il26_protein_levels__seqid___16760-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	-0.0386829	0.00825039	0.000002775363	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRTM4 protein levels (SeqId = 6572-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRTM4 protein levels (SeqId = 6572-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane neuronal protein 4	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.53	0.113	0.0000028	None	Gadd-DA_lrrtm4_protein_levels__seqid___6572-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0386279	0.00825041	0.000002867138	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0386095	0.00825042	0.000002898599	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS7B protein levels (SeqId = 12384-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS7B protein levels (SeqId = 12384-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 7b	774	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	1.17	0.25	0.0000029	None	Gadd-DA_cops7b_protein_levels__seqid___12384-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.0384784	0.00825046	0.000003131722	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0383607	0.00825049	0.000003356344	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.0011	0.00024	0.0000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.0380676	0.00825059	0.000003984876	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	-0.0375154	0.00816764	0.000004401844	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.228852	0.0506892	0.000006377746	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0372369	0.00825085	0.000006438202	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0372044	0.00825086	0.000006558988	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	-0.036462	0.00810219	0.000006839294	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Zhao N	1989 CLUE II cohort	34008478	12-01-2020	lung cancer	None	None	Supplemental Table 1	lung cancer	DNA methylation	Age, Sex, Smoking, Body mass index, batch effects, pack-years based smoking methylation score, cell composition (reference based)	None	Other	Illumina HumanMethylationEPIC	whole blood	208 cases and 222 controls. Results are given as logOR corresponding to each 1% increase of methylation beta value	430	1	Adults	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.235	0.0529	0.0000089	None	34008478_Zhao-N_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0516126	0.0117125	0.00001057357	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.0412596	0.00939246	0.00001126631	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0362258	0.00825115	0.00001139393	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0507702	0.0115774	0.0000116642	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	-0.0351428	0.00807928	0.0000137213	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0506175	0.0117515	0.00001663091	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0497198	0.0115993	0.0000182705	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.035276	0.00825143	0.00001922265	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF3 protein levels (SeqId = 4840-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF3 protein levels (SeqId = 4840-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulocyte colony-stimulating factor	774	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	0.958	0.227	0.000025	None	Gadd-DA_csf3_protein_levels__seqid___4840-73__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0496871	0.011818	0.00002633861	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0658498	0.0156734	0.0000266866	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Zhao N	CLUE I, CLUE II	34008478	05-31-2021	Lung cancer	MONDO_0008903	smoking score unadjusted	Supplementary Table 2	Lung cancer	DNA methylation	Age, Sex, Smoking, Batch effects, Body mass index, cell composition (reference based)	None	Beta values	Illumina HumanMethylationEPIC	whole blood	even though they adjust for smoking status, they dont adjust for smoking status score like their other EWAS	430	1	Adults	Both	European	cg27436184	chr19:45449006	19	45449006	APOC2	Open sea	0.219	0.0522	0.000027	None	34008478_Zhao-N_lung_cancer_smoking_score_unadjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.048562	0.0117826	0.00003784853	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	-0.0338397	0.00825184	0.00004138314	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	0.0337844	0.00825186	0.00004259815	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0634745	0.0155243	0.00004360739	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0333984	0.00825197	0.00005207136	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	-0.0333785	0.00825197	0.00005260931	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13119609	chr19:45449297	19	45449297	APOC2	Open sea	-0.0332793	0.008252	0.0000553757	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0358478	0.00891063	0.00005773963	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	0.0330397	0.00825206	0.00006263572	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0358487	0.00896927	0.00006450854	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.0328977	0.0082521	0.00006735553	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25746394	chr19:45450501	19	45450501	APOC2	Open sea	-0.0326269	0.00825218	0.00007730353	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09555818	chr19:45449301	19	45449301	APOC2	Open sea	0.0326006	0.00825218	0.00007833864	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.032507	0.00825221	0.00008213755	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10169327	chr19:45448959	19	45448959	APOC2	Open sea	-0.178306	0.0454308	0.00008714302	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	-0.0323794	0.00825224	0.00008759284	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CAMP protein levels (SeqId = 9384-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAMP protein levels (SeqId = 9384-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cathelicidin antimicrobial peptide	774	1	Adults (18-65 years)	Both	European	cg01958934	chr19:45449099	19	45449099	APOC2	Open sea	0.44	0.113	0.000089	None	Gadd-DA_camp_protein_levels__seqid___9384-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20090143	chr19:45452003	19	45452003	APOC2	Open sea	0.0321777	0.0082523	0.00009692288	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1