author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.164386 0.00814425 2.190888e-89 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.13912 0.00817628 2.623698e-64 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.138022 0.00817755 2.5787179999999996e-63 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.125996 0.00819077 5.543993e-53 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.116033 0.0082008 3.753523e-45 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3404530 (gene symbol: CLEC12A) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3404530 (gene symbol: CLEC12A) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea None None 8.7e-37 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3404530__gene_symbol__clec12a__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.101545 0.00821389 6.217764e-35 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0985119 0.00821641 5.740033e-33 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0962265 0.00821826 1.5857070000000001e-31 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0899528 0.0082231 9.598055e-28 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.08008 0.00823006 2.6184840000000003e-22 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea -0.03694 0.00337 4.3e-22 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0791496 0.00823067 7.90565e-22 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0778823 0.00823149 3.488254e-21 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.014 0.00115 8.5e-21 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.073224 0.00823441 6.665096999999999e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0731658 0.00823444 7.103383999999999e-19 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0724148 0.00823489 1.606728e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0721309 0.00823506 2.182697e-18 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0719808 0.00823515 2.565307e-18 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0716204 0.00823537 3.775593e-18 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0690504 0.00823686 5.619849000000001e-17 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0685936 0.00823712 8.990746e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.067969 0.00823748 1.700629e-16 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3404549 (gene symbol: CLEC12B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3404549 (gene symbol: CLEC12B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea None None 1.9e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3404549__gene_symbol__clec12b__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0668527 0.0082381 5.238335e-16 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0646369 0.00823931 0.000000000000004629224 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0632089 0.00824006 0.00000000000001814742 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0630436 0.00824015 0.00000000000002121581 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.042 0.00476 0.000000000000022 None 32795589_Kyung-WK_atopy_discovery Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.041 0.00475 0.000000000000069 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0616872 0.00824085 0.0000000000000752998 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3404530 (gene symbol: CLEC12A) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3404530 (gene symbol: CLEC12A) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea None None 0.00000000000017 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3404530__gene_symbol__clec12a__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.013 0.0018 0.00000000000041 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0596638 0.00824186 0.0000000000004740642 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0587051 0.00824233 0.00000000000111001 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04725405 chr12:10127367 12 10127367 CLEC12A Open sea 0.0015 None 0.0000000000016 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0581135 0.00824262 0.000000000001864091 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0576868 0.00824282 0.000000000002700831 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0573789 0.00824297 0.000000000003523342 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0566544 0.00824331 0.000000000006550667 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0557476 0.00824373 0.00000000001408293 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0539491 0.00824455 0.0000000000620427 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.03539 0.00517 0.0000000001 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0529318 0.008245 0.0000000001405871 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0524902 0.00824519 0.0000000001995904 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0523697 0.00824524 0.0000000002194958 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0517071 0.00824553 0.0000000003689728 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0516351 0.00824556 0.0000000003902416 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Knijnenburg None 30833390 Mar 19, 2019 very early preterm birth (<28 weeks) EFO_0003917 discovery Supplementary dataset 10 DNA methylation very early preterm birth (<28 weeks) Age, Ancestry (genomic PCs), time since birth M values None Illumina HumanMethylation450 whole blood None 784 1 Adults Females Admixed cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.39 0.062 0.00000000077 None 30833390_Knijnenburg_very_early_preterm_birth___28_weeks__discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0507201 0.00824594 0.0000000007903441 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0503979 0.00824608 0.000000001010449 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0016 0.00027 0.0000000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0488672 0.00824671 0.000000003180154 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0484887 0.00824686 0.000000004200531 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0481986 0.00824698 0.000000005192001 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0471634 0.00824738 0.00000001095049 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0468187 0.00824752 0.00000001399113 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0458503 0.00824789 0.00000002760073 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0458011 0.00824791 0.00000002855817 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0453707 0.00824807 0.00000003844705 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg11748728 chr12:10132541 12 10132541 CLEC12A Open sea -0.018 0.00308 0.000000044 None 32795589_Kyung-WK_atopy_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.07 0.01284 0.000000046 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.044822 0.00824827 0.00000005594871 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0794298 0.0148042 0.00000008201253 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.044187 0.00824851 0.00000008590857 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0438067 0.00824865 0.0000001107553 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg04725405 chr12:10127367 12 10127367 CLEC12A Open sea -0.02248 0.0042 0.000000118 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.043549 0.00824874 0.0000001314002 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0433714 0.0082488 0.0000001477497 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.00090094 0.00017103 0.000000167 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0431196 0.00824889 0.0000001743435 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0766188 0.0146702 0.0000001787043 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0430647 0.00824891 0.0000001807322 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 1.6 0.307 0.00000021 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0426862 0.00824905 0.0000002313073 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0423129 0.00824918 0.0000002944528 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0420792 0.00824926 0.0000003421467 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0418088 0.00824935 0.0000004066267 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.037 0.00731 0.00000041 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0417027 0.00824939 0.0000004350218 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0415776 0.00824943 0.0000004709247 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0408401 0.00824968 0.0000007484124 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0407389 0.00824972 0.0000007970661 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0405564 0.00824978 0.0000008926104 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0401311 0.00824992 0.000001159835 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0399973 0.00824996 0.000001258737 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0015 None 0.0000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0704293 0.0145504 0.0000013091 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0394405 0.00825015 0.000001764875 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.07007 0.0146861 0.000001849261 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0393403 0.00825018 0.000001874651 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.070188 0.0147431 0.000001947396 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Reese SE PACE 30579849 2018-12-21 Asthma EFO_0000270 Meta-analysis with DNAm measured in children Table 2 Asthma DNA methylation Batch effects, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 2862 9 Children Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea -8.8 1.9 0.0000021 None 30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04725405 chr12:10127367 12 10127367 CLEC12A Open sea 0.0389825 0.0082503 0.000002322696 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0388381 0.00825034 0.00000253128 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.120442 0.0256122 0.000002593126 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0391386 0.00835341 0.00000281998 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0399173 0.00856821 0.000003208976 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0383255 0.00825051 0.000003426431 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04725405 chr12:10127367 12 10127367 CLEC12A Open sea 0.008 0.0017 0.0000041 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea 0.0378784 0.00825065 0.000004448665 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0378775 0.00825065 0.000004451133 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.193063 0.0420666 0.000004475154 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.037746 0.00825069 0.000004803688 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.066397 0.0145352 0.000004963906 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea None None 0.0000059 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.065206 0.0144031 0.000006023717 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.077 0.017 0.0000063 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0370154 0.00825091 0.000007304777 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11588802 chr12:10113604 12 10113604 CLEC12A Open sea 0.0400058 0.0089559 0.000007992464 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.036786 0.00825098 0.000008319453 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0371109 0.00833036 0.00000845561 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0365687 0.00825105 0.000009403649 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0438606 0.0099594 0.00001070557 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0367288 0.00837022 0.00001151814 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0367835 0.00838757 0.00001165404 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01304461 chr12:10103711 12 10103711 CLEC12A Open sea -0.096585 0.02205 0.00001193597 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0358913 0.00825125 0.00001371781 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11588802 chr12:10113604 12 10113604 CLEC12A Open sea 0.035813 0.00824344 0.00001405787 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0407599 0.00939836 0.00001454584 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.176098 0.040989 0.00001746314 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0365434 0.00853612 0.00001872115 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0351441 0.00825147 0.00002064975 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0350372 0.0082515 0.00002188015 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0350276 0.0082515 0.00002199368 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0361724 0.00853529 0.00002269164 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0362365 0.00855551 0.00002294757 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0347548 0.00825158 0.00002547445 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0352097 0.00837749 0.00002650824 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.0359776 0.00859079 0.00002831625 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.0344681 0.00825167 0.00002969511 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LTA protein levels (SeqId = 3505-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LTA protein levels (SeqId = 3505-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta 774 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.83 0.199 0.00003 None Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea -0.0344462 0.00825167 0.00003004222 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.034378 0.00825169 0.00003115282 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11588802 chr12:10113604 12 10113604 CLEC12A Open sea 0.148016 0.0356087 0.00003243614 None 39706196_Hannah-M.-Smith_bmi_discovery Eze Inkenna SCSAP, LHDA 32484729 2020-06-01 Particulate matter air pollution EFO_0007908, EFO_0008255 None Table S6 DNA methylation Particulate matter air pollution Age, sex, educational attainment, smoking, passive smoking, alcohol, fruit intake, vegetable intake, body mass index, exercise level, asthma status, batch effects, cell composition (reference free), socioeconomic position, greenness index Beta Values None Illumina HumanMethylation450 Whole blood None 1389 1 Adults Both Unclear cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0198 0.00476 0.000033 None 32484729_Eze-Inkenna_particulate_matter_air_pollution Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.0342225 0.00825174 0.00003382905 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FCER2 protein levels (SeqId = 3291-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCER2 protein levels (SeqId = 3291-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor 774 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea 0.82 0.198 0.000034 None Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0387674 0.00938581 0.00003641016 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0340609 0.00825178 0.00003684384 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11588802 chr12:10113604 12 10113604 CLEC12A Open sea 0.0340106 0.00824456 0.00003724221 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_2 Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model3_Adolescence None DNA methylation Maternal education at the time of pregnancy Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Gestational age, offspring BMI, offspring smoking Beta values years of schooling Illumina HumanMethylation450 Whole blood Illumina HumanMethylationEPIC was also used for some cohorts 2740 None Children Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea -0.00066 0.00016 0.000038 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model3_adolescence Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea 0.0339313 0.00825182 0.00003944097 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.034259 0.00838649 0.00004430777 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea 0.0335669 0.00825192 0.00004771384 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea 0.033561 0.00825192 0.000047861 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Cardenas A Project Viva 31300640 Jul 12, 2019 allergic asthma MONDO_0004784 None Supplementary Data 3 DNA methylation allergic asthma Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values None Illumina HumanMethylationEPIC nasal epithelium None 277 1 Children Both Other cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea -2.51 0.61 0.000051 SE manually calculated 31300640_Cardenas-A_allergic_asthma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0338336 0.00835849 0.00005196235 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg25837258 chr12:10102605 12 10102605 CLEC12A Open sea -0.184927 0.0457301 0.00005279536 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea 0.0333088 0.00825199 0.00005453871 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea 0.0330366 0.00825206 0.00006273574 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01304461 chr12:10103711 12 10103711 CLEC12A Open sea 0.0877372 0.0219325 0.00006356374 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11588802 chr12:10113604 12 10113604 CLEC12A Open sea 0.0327865 0.00825213 0.00007128361 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0576658 0.0145211 0.00007186254 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PAIP1 protein levels (SeqId = 12430-78) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAIP1 protein levels (SeqId = 12430-78) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyadenylate-binding protein-interacting protein 1 774 1 Adults (18-65 years) Both European cg11748728 chr12:10132541 12 10132541 CLEC12A Open sea -0.32 0.081 0.000075 None Gadd-DA_paip1_protein_levels__seqid___12430-78__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea 0.0365517 0.00923163 0.00007549295 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13233583 chr12:10126938 12 10126938 CLEC12A Open sea -0.0585015 0.0147967 0.00007731681 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10223809 chr12:10103550 12 10103550 CLEC12A Open sea -0.0370348 0.00937123 0.0000778734 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01293277 chr12:10123440 12 10123440 CLEC12A Open sea -0.0325365 0.0082522 0.00008092162 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11905488 chr12:10123604 12 10123604 CLEC12A Open sea 0.0325011 0.00825221 0.0000823798 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03014680 chr12:10122522 12 10122522 CLEC12A Open sea -0.0324944 0.00825221 0.00008266016 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TRAPPC5 protein levels (SeqId = 8671-378) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TRAPPC5 protein levels (SeqId = 8671-378) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trafficking protein particle complex subunit 5 774 1 Adults (18-65 years) Both European cg11748728 chr12:10132541 12 10132541 CLEC12A Open sea -0.32 0.081 0.000083 None Gadd-DA_trappc5_protein_levels__seqid___8671-378__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNMT3L protein levels (SeqId = 19142-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNMT3L protein levels (SeqId = 19142-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA (cytosine-5)-methyltransferase 3-like 774 1 Adults (18-65 years) Both European cg11748728 chr12:10132541 12 10132541 CLEC12A Open sea -0.31 0.081 0.000095 None Gadd-DA_dnmt3l_protein_levels__seqid___19142-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BMPR2 protein levels (SeqId = 4862-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMPR2 protein levels (SeqId = 4862-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein receptor type-2 774 1 Adults (18-65 years) Both European cg11748728 chr12:10132541 12 10132541 CLEC12A Open sea -0.31 0.081 0.000097 None Gadd-DA_bmpr2_protein_levels__seqid___4862-63__somascan_protein_measurement