author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	0.0026	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-0.013	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-0.043	0.0021	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	0.00071	0.000072	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.0012	0.000081	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886711	chr12:48399180	12	48399180	COL2A1	Island	-0.019	0.0018	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	0.0042	0.00021	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-0.016	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-0.058	0.0028	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	-0.0011	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.029	0.002	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	0.0015	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.022	0.0016	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22861561	chr12:48397730	12	48397730	COL2A1	North shore	0.0012	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06118478	chr12:48389984	12	48389984	COL2A1	Open sea	0.54622	0.00666	6.1e-152	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15108410	chr12:48375673	12	48375673	COL2A1	Open sea	0.40084	0.00576	1.2e-138	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.34656	0.00582	3.5e-126	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19451673	chr12:48398730	12	48398730	COL2A1	Island	-0.20092	0.00377	1.7e-117	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.23318	0.00526	4.2e-103	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-0.25132	0.00579	1.7e-101	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08886711	chr12:48399180	12	48399180	COL2A1	Island	-0.1694	0.00467	3.5e-88	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-0.11685	0.00333	1e-85	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	0.05049	0.00156	6.1e-80	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22861561	chr12:48397730	12	48397730	COL2A1	North shore	0.11147	0.00357	2.1e-77	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13565575	chr12:48397568	12	48397568	COL2A1	North shore	-0.09493	0.00309	2.7e-76	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05342945	chr12:48394962	12	48394962	COL2A1	North shore	0.03945	0.00149	4.5000000000000003e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13554901	chr12:48396630	12	48396630	COL2A1	North shore	0.00037	None	1.2999999999999999e-61	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07561017	chr12:48398056	12	48398056	COL2A1	Island	0.00057	None	3.2e-61	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19426944	chr12:48397225	12	48397225	COL2A1	North shore	0.00033	None	6.9e-56	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-2.10055	0.05668	4.5299999999999994e-55	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24011408	chr12:48396354	12	48396354	COL2A1	North shore	0.08783	0.00403	6.4e-54	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01291404	chr12:48397872	12	48397872	COL2A1	North shore	0.02626	0.00126	3.4e-51	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.00036	None	4.1e-51	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17054969	chr12:48398374	12	48398374	COL2A1	Island	0.00013	None	5.4e-46	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18719723	chr12:48395490	12	48395490	COL2A1	Island	0.02253	0.0012	1.3e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13565575	chr12:48397568	12	48397568	COL2A1	North shore	0.0005	None	2.9999999999999998e-40	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15465823	chr12:48382534	12	48382534	COL2A1	Open sea	0.03285	0.00205	2.8e-37	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-2.3413	0.11356	3.0400000000000003e-35	-	25282492_fetal_vs_adult_liver
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.00017	None	1.3e-34	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08715466	chr12:48391776	12	48391776	COL2A1	North shelf	-0.02715	0.00185	3e-33	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.02675	0.00185	1.4e-32	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19426944	chr12:48397225	12	48397225	COL2A1	North shore	-0.02626	0.00185	7.999999999999999e-32	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-1.40758	0.08383	4.95e-29	-	25282492_fetal_vs_adult_liver
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-	-	5.750000000000001e-29	-	26500701_sex_kora_f4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19451673	chr12:48398730	12	48398730	COL2A1	Island	0.00036	None	3.7e-28	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	0.00068	None	4.9e-25	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-	-	2.4399999999999999e-23	-	26500701_sex_kora_f4
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-	-	8.100000000000001e-22	-	26500701_sex_kora_f4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	-0.01433	0.00144	4.1e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.00069	None	1.9e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	0.02399	0.00251	6.1e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg06118478	chr12:48389984	12	48389984	COL2A1	Open sea	-0.52871	0.0632	5.96e-17	-	25650246_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	COL2A1 protein levels (SeqId = 18875-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL2A1 protein levels (SeqId = 18875-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-1(II) chain	774	1	Adults (18-65 years)	Both	European	cg23881939	chr12:48391054	12	48391054	COL2A1	Open sea	-0.21	0.025	1.3e-16	None	Gadd-DA_col2a1_protein_levels__seqid___18875-125__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20255775	chr12:48398370	12	48398370	COL2A1	Island	0.00013	None	0.0000000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Replication	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	445	1	79	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-	-	0.00000000000000244	-	25249537_sex_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19451673	chr12:48398730	12	48398730	COL2A1	Island	0.0003	0.000038	0.0000000000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-	-	0.00000000000000385	-	26500701_sex_kora_f4
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3453120 (gene symbol: ZNF641)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3453120 (gene symbol: ZNF641)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg24011408	chr12:48396354	12	48396354	COL2A1	North shore	None	None	0.0000000000000056	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3453120__gene_symbol__znf641__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06118478	chr12:48389984	12	48389984	COL2A1	Open sea	-0.00078	0.0001	0.000000000000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-	-	0.0000000000000367	-	26500701_sex_kora_f3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13554901	chr12:48396630	12	48396630	COL2A1	North shore	0.00095	None	0.000000000000039	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07561017	chr12:48398056	12	48398056	COL2A1	Island	0.0013	None	0.00000000000017	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13554901	chr12:48396630	12	48396630	COL2A1	North shore	0.01427	0.00181	0.00000000000023	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg08886711	chr12:48399180	12	48399180	COL2A1	Island	-	-	0.000000000000331	-	26500701_sex_kora_f4
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-	-	0.00000000000206	-	26500701_sex_kora_f3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.00078	None	0.0000000000024	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.00052	None	0.0000000000037	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19066141	chr12:48395868	12	48395868	COL2A1	Island	0.00942	0.00129	0.0000000000062	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg07561017	chr12:48398056	12	48398056	COL2A1	Island	-	-	0.000000000014	-	23526956_clear_cell_renal_carcinoma
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-	-	0.0000000000363	-	26500701_sex_kora_f3
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	main	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.00469	0.00071	0.000000000038	None	33279932_Li-M_schizophrenia_main
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01291404	chr12:48397872	12	48397872	COL2A1	North shore	0.00043	None	0.000000000041	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05342945	chr12:48394962	12	48394962	COL2A1	North shore	0.00059	None	0.000000000056	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19451673	chr12:48398730	12	48398730	COL2A1	Island	0.01161	0.0018	0.000000000125	-	23334450_rheumatoid_arthritis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.00914	0.00135	0.00000000016	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	adjusted for cell composition	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	None	None	0.00000000025	None	33279932_Li-M_schizophrenia_adjusted_for_cell_composition
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19426944	chr12:48397225	12	48397225	COL2A1	North shore	0.01238	0.002	0.000000000347	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886711	chr12:48399180	12	48399180	COL2A1	Island	0.0011	0.00017	0.00000000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Cord blood	Supplementary table 8	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	cord blood	None	179	1	Infants	Both	European, African, Other	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	None	None	0.00000000042	None	34569420_Bozack_infant_sex_cord_blood
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg17054969	chr12:48398374	12	48398374	COL2A1	Island	-	-	0.000000000484	-	24500968_pancreatic_ductal_adenocarcinoma
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg20255775	chr12:48398370	12	48398370	COL2A1	Island	-	-	0.000000000599	-	24500968_pancreatic_ductal_adenocarcinoma
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg07561017	chr12:48398056	12	48398056	COL2A1	Island	1.702219	0.2752	0.000000000617	-	27105112_hiv_infection_discovery
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	0.11822	0.0193	0.00000000082	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	-0.258362	0.0420956	0.0000000008556916	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.00978	0.00164125	0.00000000127	-	28811542_age
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-	-	0.00000000129	-	26500701_sex_kora_f3
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Cord blood	Supplementary table 8	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	cord blood	None	179	1	Infants	Both	European, African, Other	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	None	None	0.000000002	None	34569420_Bozack_infant_sex_cord_blood
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	0.1459	0.0245	0.0000000026	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	0.257648	0.0432878	0.000000002700286	None	39706196_Hannah-M.-Smith_bmi_discovery
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Cord blood	Supplementary table 8	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	cord blood	None	179	1	Infants	Both	European, African, Other	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	None	None	0.000000005	None	34569420_Bozack_infant_sex_cord_blood
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08715466	chr12:48391776	12	48391776	COL2A1	North shelf	0.00073	None	0.0000000055	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22861561	chr12:48397730	12	48397730	COL2A1	North shore	0.0011	None	0.000000006	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Discovery	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	815	1	70	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-	-	0.00000000771	-	25249537_sex_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	1.420737	0.247	0.00000000882	-	27105112_hiv_infection_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13330524	chr12:48395720	12	48395720	COL2A1	Island	0.007	0.00117	0.000000011	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Cord blood	Supplementary table 8	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	cord blood	None	179	1	Infants	Both	European, African, Other	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	None	None	0.000000018	None	34569420_Bozack_infant_sex_cord_blood
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Replication	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	445	1	79	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-	-	0.0000000198	-	25249537_sex_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19451673	chr12:48398730	12	48398730	COL2A1	Island	0.001	None	0.000000021	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	0.0012	None	0.000000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01291404	chr12:48397872	12	48397872	COL2A1	North shore	0.00032	0.000058	0.000000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	0.0019	None	0.000000046	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	-0.0448249	0.00824827	0.00000005583978	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19066141	chr12:48395868	12	48395868	COL2A1	Island	0.00982	0.0018	0.0000000697	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00360679	chr12:48374327	12	48374327	COL2A1	Open sea	0.0441323	0.00824853	0.00000008911263	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	0.11095	0.0208	0.000000102	-	25650246_gestational_age
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg15418534	chr12:48392797	12	48392797	COL2A1	North shelf	-0.022	0.00421	0.00000013	None	Robert-F-Hillary_Incident_COPD_Basic_model
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Replication	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	445	1	79	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-	-	0.000000137	-	25249537_sex_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.0021	None	0.00000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08886711	chr12:48399180	12	48399180	COL2A1	Island	0.0013	None	0.00000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00130004	chr12:48385408	12	48385408	COL2A1	Open sea	-0.22169	0.0421727	0.0000001482995	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	0.00093	0.00018	0.00000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19426944	chr12:48397225	12	48397225	COL2A1	North shore	0.0009	None	0.00000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	0.001	0.0002	0.00000027	None	33450751_Mulder-RH_age_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0424095	0.00824914	0.0000002766776	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COL2A1 protein levels (SeqId = 18875-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL2A1 protein levels (SeqId = 18875-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-1(II) chain	774	1	Adults (18-65 years)	Both	European	cg18233424	chr12:48384159	12	48384159	COL2A1	Open sea	0.63	0.124	0.0000003	None	Gadd-DA_col2a1_protein_levels__seqid___18875-125__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0420147	0.00824928	0.000000356565	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Yang BZ	-	23332324	2013-02-01	Child abuse	-	-	Appendix B	DNA methylation	Child abuse	Sex, age and ethnicity	Beta values	-	Illumina HumanMethylation450	Saliva	-	192	1	10	Both	European,African,Admixed,Other	cg18719723	chr12:48395490	12	48395490	COL2A1	Island	-	-	0.000000359	-	23332324_child_abuse
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Discovery	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	815	1	70	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-	-	0.000000432	-	25249537_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	COL2A1 protein levels (SeqId = 18875-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL2A1 protein levels (SeqId = 18875-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-1(II) chain	774	1	Adults (18-65 years)	Both	European	cg15505953	chr12:48383223	12	48383223	COL2A1	Open sea	1	0.199	0.00000045	None	Gadd-DA_col2a1_protein_levels__seqid___18875-125__somascan_protein_measurement
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.00028	0.000055	0.00000048	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	-0.0415419	0.00824944	0.0000004816933	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg20255775	chr12:48398370	12	48398370	COL2A1	Island	1.391968	0.278	0.000000552	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00360679	chr12:48374327	12	48374327	COL2A1	Open sea	0.0413938	0.00843133	0.0000009228237	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	-0.040499	0.0082498	0.0000009248244	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00360679	chr12:48374327	12	48374327	COL2A1	Open sea	0.0412561	0.00843529	0.00000101447	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0403093	0.00824986	0.000001039607	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.0052	0.0011	0.0000011	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	-0.0401359	0.00824992	0.00000115642	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-1.251579	0.2602	0.00000152	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	0.0395192	0.00825012	0.00000168295	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13565575	chr12:48397568	12	48397568	COL2A1	North shore	0.00099	None	0.0000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Discovery	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	815	1	70	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-	-	0.00000197	-	25249537_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	0.205869	0.0432701	0.000001973197	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	Meta-analysis	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1999	3	35.7	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-	-	0.00000278	-	26500701_sex_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0384951	0.00825045	0.000003101016	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	0.201974	0.0434042	0.00000329019	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg02165500	chr12:48378581	12	48378581	COL2A1	Open sea	-0.96	0.207	0.0000033	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05342945	chr12:48394962	12	48394962	COL2A1	North shore	0.0017	None	0.0000036	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17054969	chr12:48398374	12	48398374	COL2A1	Island	0.00034	None	0.0000039	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PLEKHA7 protein levels (SeqId = 12731-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLEKHA7 protein levels (SeqId = 12731-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pleckstrin homology domain-containing family A member 7	774	1	Adults (18-65 years)	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.83	0.18	0.0000042	None	Gadd-DA_plekha7_protein_levels__seqid___12731-12__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00102405	chr12:48382339	12	48382339	COL2A1	Open sea	-0.0378991	0.00825064	0.000004395554	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RSPO2 protein levels (SeqId = 8409-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RSPO2 protein levels (SeqId = 8409-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: R-spondin-2	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.77	0.168	0.0000045	None	Gadd-DA_rspo2_protein_levels__seqid___8409-3__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg13554901	chr12:48396630	12	48396630	COL2A1	North shore	1.353463	0.2954	0.00000463	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	POTEG protein levels (SeqId = 7960-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	POTEG protein levels (SeqId = 7960-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: POTE ankyrin domain family member G	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.77	0.169	0.0000048	None	Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg22861561	chr12:48397730	12	48397730	COL2A1	North shore	-0.02	0.00447	0.0000051	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	0.0375173	0.00825076	0.000005481644	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg20255775	chr12:48398370	12	48398370	COL2A1	Island	0.192592	0.0425	0.00000571	-	27105112_hiv_infection_neutrophils
Gadd DA	Generation Scotland	35945220	31/07/2022	LRP8 protein levels (SeqId = 3323-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRP8 protein levels (SeqId = 3323-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low-density lipoprotein receptor-related protein 8	774	1	Adults (18-65 years)	Both	European	cg24011408	chr12:48396354	12	48396354	COL2A1	North shore	-0.65	0.144	0.000006	None	Gadd-DA_lrp8_protein_levels__seqid___3323-37__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02165500	chr12:48378581	12	48378581	COL2A1	Open sea	-0.164971	0.0366586	0.000006831389	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ICOSLG protein levels (SeqId = 5061-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICOSLG protein levels (SeqId = 5061-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ICOS ligand	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.75	0.169	0.0000079	None	Gadd-DA_icoslg_protein_levels__seqid___5061-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	0.0368451	0.00825097	0.000008046046	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Paulina Jedynak	EDEN French birth cohort	34523531	Aug 21, 2021	Pregnancy exposure to Triclosan	CHEBI_33853	Adjusted for cell composition	EDEN French birth cohort	DNA methylation	Pregnancy exposure to Triclosan	Age, Smoking, Batch effects, Education, Cell composition (reference based), center of recruitment, parity, season of conception	Beta values	None	Illumina HumanMethylation450	Placenta	None	202	1	Infants (< 4 years)	Males	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	0.0043	0.00097	0.0000084	None	34523531_Paulina-Jedynak_pregnancy_exposure_to_triclosan_adjusted_for_cell_composition
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg12235144	chr12:48398329	12	48398329	COL2A1	Island	1.204109	0.2714	0.00000912	-	27105112_hiv_infection_discovery
Paulina Jedynak	EDEN French birth cohort	34523531	Aug 21, 2021	Pregnancy exposure to Triclosan	CHEBI_33853	Unadjusted for cell counts	EDEN French birth cohort	DNA methylation	Pregnancy exposure to Triclosan	Age, Smoking, Batch effects, Education, center of recruitment, parity, season of conception	Beta values	None	Illumina HumanMethylation450	Placenta	None	202	1	Infants (< 4 years)	Males	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	0.0053	0.0012	0.0000098	None	34523531_Paulina-Jedynak_pregnancy_exposure_to_triclosan_unadjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.0365339	0.00836028	0.00001251366	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TAX1BP1 protein levels (SeqId = 12721-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAX1BP1 protein levels (SeqId = 12721-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tax1-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.74	0.169	0.000013	None	Gadd-DA_tax1bp1_protein_levels__seqid___12721-4__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	0.002	0.00047	0.000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.0359924	0.0083018	0.00001464073	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15465823	chr12:48382534	12	48382534	COL2A1	Open sea	-0.0357583	0.00825129	0.00001476239	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19426944	chr12:48397225	12	48397225	COL2A1	North shore	-1.095359	0.254	0.0000162	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	0.0044	0.001	0.000017	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0371835	0.00871513	0.00001997692	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CUL9 protein levels (SeqId = 12991-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CUL9 protein levels (SeqId = 12991-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cullin-9	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.72	0.169	0.00002	None	Gadd-DA_cul9_protein_levels__seqid___12991-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CNTN2 protein levels (SeqId = 3296-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNTN2 protein levels (SeqId = 3296-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Contactin-2	774	1	Adults (18-65 years)	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.769	0.18	0.00002	None	Gadd-DA_cntn2_protein_levels__seqid___3296-92__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130004	chr12:48385408	12	48385408	COL2A1	Open sea	-0.0351123	0.00825148	0.0000210085	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08715466	chr12:48391776	12	48391776	COL2A1	North shelf	0.0023	None	0.000022	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	FCER2 protein levels (SeqId = 3291-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCER2 protein levels (SeqId = 3291-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor	774	1	Adults (18-65 years)	Both	European	cg02165500	chr12:48378581	12	48378581	COL2A1	Open sea	-0.87	0.206	0.000022	None	Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.035023	0.00825151	0.00002204901	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0363756	0.00863133	0.0000251981	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	0.00068	None	0.000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Yousefi P	-	26553366	2015-11-09	Sex	PATO_0000047	-	Additional file 1	DNA methylation	Sex	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord Blood	-	111	1	0	Both	Admixed	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	0.54012168	0.1288	0.0000274	-	26553366_sex
Gadd DA	Generation Scotland	35945220	31/07/2022	PGK1 protein levels (SeqId = 5020-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGK1 protein levels (SeqId = 5020-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate kinase 1	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.7	0.168	0.000028	None	Gadd-DA_pgk1_protein_levels__seqid___5020-50__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00130004	chr12:48385408	12	48385408	COL2A1	Open sea	0.180115	0.0431336	0.00002984574	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.0344493	0.00825167	0.00002999269	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	0.0346568	0.00830586	0.00003029102	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.0022	0.00052	0.000032	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCD6 protein levels (SeqId = 19488-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCD6 protein levels (SeqId = 19488-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Programmed cell death protein 6	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.7	0.168	0.000032	None	Gadd-DA_pdcd6_protein_levels__seqid___19488-1__somascan_protein_measurement
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	0.006	0.002	0.0000321	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0344561	0.00831576	0.00003440129	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	-0.0340812	0.00825177	0.0000364516	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0342759	0.00831818	0.00003799539	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07650504	chr12:48397055	12	48397055	COL2A1	North shore	0.033933	0.00825182	0.00003940663	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	WDR5 protein levels (SeqId = 17760-128)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WDR5 protein levels (SeqId = 17760-128)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WD repeat-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.69	0.169	0.00004	None	Gadd-DA_wdr5_protein_levels__seqid___17760-128__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.0329898	0.00803256	0.00004029859	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	0.0342973	0.00835275	0.00004045731	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	COVID-19 Severity (Hospitalisation)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	COVID-19 Severity (Hospitalisation)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	5246	1	Adults (18-65y)	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	0.042	0.0103	0.000042	None	Robert-F-Hillary_COVID-19_Severity_(Hospitalisation)_Basic_model
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg12235144	chr12:48398329	12	48398329	COL2A1	Island	0.190731	0.0466	0.0000423	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0340082	0.00832287	0.00004409844	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22861561	chr12:48397730	12	48397730	COL2A1	North shore	0.0031	None	0.000046	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	MRAS protein levels (SeqId = 18297-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRAS protein levels (SeqId = 18297-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein M-Ras	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.69	0.169	0.000047	None	Gadd-DA_mras_protein_levels__seqid___18297-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18233424	chr12:48384159	12	48384159	COL2A1	Open sea	0.0338368	0.00832581	0.00004847328	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15505953	chr12:48383223	12	48383223	COL2A1	Open sea	0.0335313	0.00825193	0.00004860409	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKCB protein levels (SeqId = 5475-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKCB protein levels (SeqId = 5475-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein kinase C beta type	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.000049	None	Gadd-DA_prkcb_protein_levels__seqid___5475-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PLS1 protein levels (SeqId = 12737-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLS1 protein levels (SeqId = 12737-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plastin-1	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.00005	None	Gadd-DA_pls1_protein_levels__seqid___12737-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SVIP protein levels (SeqId = 18285-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SVIP protein levels (SeqId = 18285-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small VCP/p97-interacting protein	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.169	0.000051	None	Gadd-DA_svip_protein_levels__seqid___18285-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CA8 protein levels (SeqId = 11390-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CA8 protein levels (SeqId = 11390-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbonic anhydrase-related protein	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.000051	None	Gadd-DA_ca8_protein_levels__seqid___11390-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PACSIN3 protein levels (SeqId = 14674-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACSIN3 protein levels (SeqId = 14674-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein kinase C and casein kinase substrate in neurons protein 3	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.000051	None	Gadd-DA_pacsin3_protein_levels__seqid___14674-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	-0.0361942	0.00894433	0.00005223148	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	BMPR2 protein levels (SeqId = 4862-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BMPR2 protein levels (SeqId = 4862-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone morphogenetic protein receptor type-2	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.000053	None	Gadd-DA_bmpr2_protein_levels__seqid___4862-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKT2 protein levels (SeqId = 14685-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKT2 protein levels (SeqId = 14685-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RAC-beta serine/threonine-protein kinase	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.169	0.000053	None	Gadd-DA_akt2_protein_levels__seqid___14685-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15001729	chr12:48383493	12	48383493	COL2A1	Open sea	-0.0336399	0.00832707	0.00005376421	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	KIF23 protein levels (SeqId = 5228-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIF23 protein levels (SeqId = 5228-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kinesin-like protein KIF23	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.169	0.000054	None	Gadd-DA_kif23_protein_levels__seqid___5228-25__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02165500	chr12:48378581	12	48378581	COL2A1	Open sea	-0.0328223	0.00813095	0.00005448215	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15505953	chr12:48383223	12	48383223	COL2A1	Open sea	-0.0332677	0.008252	0.00005570919	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0334283	0.00829357	0.00005590901	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CDH15 protein levels (SeqId = 5410-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDH15 protein levels (SeqId = 5410-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cadherin-15	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.169	0.000056	None	Gadd-DA_cdh15_protein_levels__seqid___5410-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GALNT10 protein levels (SeqId = 7003-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GALNT10 protein levels (SeqId = 7003-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polypeptide N-acetylgalactosaminyltransferase 10	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.68	0.168	0.000056	None	Gadd-DA_galnt10_protein_levels__seqid___7003-4__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00130004	chr12:48385408	12	48385408	COL2A1	Open sea	0.174099	0.0432339	0.00005675861	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06899218	chr12:48395281	12	48395281	COL2A1	North shore	-0.0332306	0.00825201	0.00005678556	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	-0.0332138	0.00825202	0.00005727821	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0351554	0.00875554	0.00005968624	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15418534	chr12:48392797	12	48392797	COL2A1	North shelf	-0.0335442	0.00835746	0.00006007484	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	HSPH1 protein levels (SeqId = 17704-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSPH1 protein levels (SeqId = 17704-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heat shock protein 105 kDa	774	1	Adults (18-65 years)	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.72	0.178	0.000061	None	Gadd-DA_hsph1_protein_levels__seqid___17704-74__somascan_protein_measurement
Sharp GC	-	25855720	2015-08-01	Maternal underweight	EFO_0005936	Birth	Additional file 1	DNA methylation	Maternal underweight	Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	601	1	0	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.01706	0.00426	0.0000612	-	25855720_maternal_underweight_birth
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPKAPK2 protein levels (SeqId = 3820-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPKAPK2 protein levels (SeqId = 3820-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAP kinase-activated protein kinase 2	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.67	0.168	0.000062	None	Gadd-DA_mapkapk2_protein_levels__seqid___3820-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ISG15 protein levels (SeqId = 14151-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISG15 protein levels (SeqId = 14151-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like protein ISG15	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.67	0.168	0.000062	None	Gadd-DA_isg15_protein_levels__seqid___14151-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	0.0328844	0.00825211	0.00006781411	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0331603	0.00832945	0.00006893075	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	S100Z protein levels (SeqId = 18928-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	S100Z protein levels (SeqId = 18928-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein S100-Z	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.669	0.168	0.000071	None	Gadd-DA_s100z_protein_levels__seqid___18928-10__somascan_protein_measurement
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg18233424	chr12:48384159	12	48384159	COL2A1	Open sea	0.1007846	0.0253935	0.0000722	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.0330759	0.00834897	0.00007478046	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	3.5	0.886	0.000075	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	NAA10 protein levels (SeqId = 17854-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAA10 protein levels (SeqId = 17854-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-alpha-acetyltransferase 10	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.664	0.168	0.000075	None	Gadd-DA_naa10_protein_levels__seqid___17854-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11698204	chr12:48382445	12	48382445	COL2A1	Open sea	-0.0353809	0.00894065	0.00007615669	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	BTK protein levels (SeqId = 19202-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTK protein levels (SeqId = 19202-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein kinase BTK	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.168	0.000078	None	Gadd-DA_btk_protein_levels__seqid___19202-10__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15108410	chr12:48375673	12	48375673	COL2A1	Open sea	-0.161876	0.0410073	0.00007927374	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ADAM19 protein levels (SeqId = 8948-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADAM19 protein levels (SeqId = 8948-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 19	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.169	0.000081	None	Gadd-DA_adam19_protein_levels__seqid___8948-13__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Leg bone mineral content	EFO_0007621	None	None	DNA methylation	Leg bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	-0.00083	0.00021	0.000081	None	Battram-T_leg_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Leg bone mass	EFO_0004512	None	None	DNA methylation	Leg bone mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg15791105	chr12:48367161	12	48367161	COL2A1	Open sea	-0.00083	0.00021	0.000081	None	Battram-T_leg_bone_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	0.0342343	0.00868808	0.00008173371	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	RANBP1 protein levels (SeqId = 18191-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RANBP1 protein levels (SeqId = 18191-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ran-specific GTPase-activating protein	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.167	0.000083	None	Gadd-DA_ranbp1_protein_levels__seqid___18191-23__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02553284	chr12:48396670	12	48396670	COL2A1	North shore	-0.032474	0.00825222	0.00008351715	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19601035	chr12:48399140	12	48399140	COL2A1	North shore	-0.0463279	0.0117754	0.00008382939	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.0326839	0.00831737	0.00008547755	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FGFRL1 protein levels (SeqId = 6237-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGFRL1 protein levels (SeqId = 6237-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroblast growth factor receptor-like 1	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.17	0.000087	None	Gadd-DA_fgfrl1_protein_levels__seqid___6237-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10502244	chr12:48399295	12	48399295	COL2A1	Island	-0.0342358	0.00872211	0.00008706414	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.0323645	0.00825225	0.00008825395	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NCR3 protein levels (SeqId = 3003-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCR3 protein levels (SeqId = 3003-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Natural cytotoxicity triggering receptor 3	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.168	0.000089	None	Gadd-DA_ncr3_protein_levels__seqid___3003-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	XRCC4 protein levels (SeqId = 9886-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	XRCC4 protein levels (SeqId = 9886-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA repair protein XRCC4	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.169	0.00009	None	Gadd-DA_xrcc4_protein_levels__seqid___9886-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ATP4B protein levels (SeqId = 9994-217)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ATP4B protein levels (SeqId = 9994-217)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Potassium-transporting ATPase subunit beta	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.169	0.00009	None	Gadd-DA_atp4b_protein_levels__seqid___9994-217__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FCRL1 protein levels (SeqId = 5728-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCRL1 protein levels (SeqId = 5728-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fc receptor-like protein 1	774	1	Adults (18-65 years)	Both	European	cg02165500	chr12:48378581	12	48378581	COL2A1	Open sea	-0.81	0.207	0.00009	None	Gadd-DA_fcrl1_protein_levels__seqid___5728-60__somascan_protein_measurement
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	Meta-analysis	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1999	3	35.7	Both	European	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	-	-	0.0000901	-	26500701_sex_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	0.0323037	0.00825226	0.00009099068	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	STX8 protein levels (SeqId = 10903-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STX8 protein levels (SeqId = 10903-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntaxin-8	774	1	Adults (18-65 years)	Both	European	cg12120327	chr12:48398535	12	48398535	COL2A1	Island	0.7	0.178	0.000091	None	Gadd-DA_stx8_protein_levels__seqid___10903-50__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17054969	chr12:48398374	12	48398374	COL2A1	Island	-0.000045	0.000012	0.000091	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18990042	chr12:48399169	12	48399169	COL2A1	Island	-0.0326744	0.00835891	0.00009312301	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg03495195	chr12:48396862	12	48396862	COL2A1	North shore	-0.001	0.00026	0.000095	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Gadd DA	Generation Scotland	35945220	31/07/2022	BTN3A3 protein levels (SeqId = 17692-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTN3A3 protein levels (SeqId = 17692-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Butyrophilin subfamily 3 member A3	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.65	0.168	0.000095	None	Gadd-DA_btn3a3_protein_levels__seqid___17692-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10661313	chr12:48371427	12	48371427	COL2A1	Open sea	-0.036538	0.009364	0.00009584119	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF1 protein levels (SeqId = 3738-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF1 protein levels (SeqId = 3738-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage colony-stimulating factor 1	774	1	Adults (18-65 years)	Both	European	cg11721803	chr12:48398380	12	48398380	COL2A1	Island	0.66	0.169	0.000097	None	Gadd-DA_csf1_protein_levels__seqid___3738-54__somascan_protein_measurement
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg01906695	chr12:48399493	12	48399493	COL2A1	South shore	0.007	0.002	0.0000977	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns