author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01669108 chr11:65646791 11 65646791 CTSW Open sea -0.0019 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18410078 chr11:65647288 11 65647288 CTSW Open sea -0.50608 0.00804 1.2000000000000002e-130 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08416661 chr11:65647279 11 65647279 CTSW Open sea -0.32727 0.00522 2.8e-130 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19792802 chr11:65647270 11 65647270 CTSW Open sea -0.30846 0.00667 2.5e-106 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18410078 chr11:65647288 11 65647288 CTSW Open sea 0.0012 None 3.9e-79 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea -0.19996 0.00658 1.6e-75 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg08416661 chr11:65647279 11 65647279 CTSW Open sea None None 2.6e-65 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01669108 chr11:65646791 11 65646791 CTSW Open sea None None 6.1e-64 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01669108 chr11:65646791 11 65646791 CTSW Open sea -0.03856 0.00248 6.2e-36 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg18410078 chr11:65647288 11 65647288 CTSW Open sea None None 5.9e-35 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0983339 0.00821656 7.454186e-33 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg23483894 chr11:65646612 11 65646612 CTSW Open sea None None 3.6e-26 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0856794 0.00822621 2.584014e-25 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg25470561 chr11:65646656 11 65646656 CTSW Open sea None None 3.4999999999999997e-25 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg19792802 chr11:65647270 11 65647270 CTSW Open sea - - 3.6e-25 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0744395 0.00823366 1.745762e-19 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08416661 chr11:65647279 11 65647279 CTSW Open sea 0.00038 None 1.3e-17 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23483894 chr11:65646612 11 65646612 CTSW Open sea -0.0015 0.00019 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea - - 0.00000000000000215 - 28056824_age_4_vs_age_0 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3335697 (gene symbol: CTSW) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03887787 chr11:65647532 11 65647532 CTSW Open sea None None 0.000000000000016 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3335697__gene_symbol__ctsw__meta-analysis Witt S None 32080920 02-02-2020 alcohol withdrawal recovery None discovery Table S1 DNA methylation alcohol withdrawal recovery Age, Smoking, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylationEPIC whole blood two weeks after vs active withdrawal 99 1 Adults Males European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 1.7 0.203 0.00000000000047 None 32080920_Witt-S_alcohol_withdrawal_recovery_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0577391 0.0082428 0.000000000002581112 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.044 0.00636 0.0000000000078 None Robert-F-Hillary_Incident_COPD_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.239318 0.0358546 0.00000000002548752 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea -0.0011 0.00017 0.000000000034 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23483894 chr11:65646612 11 65646612 CTSW Open sea -0.01168 0.0017 0.000000000091 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23483894 chr11:65646612 11 65646612 CTSW Open sea 0.0014 None 0.000000000098 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea -0.222831 0.0350197 0.000000000202539 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0523175 0.00824526 0.0000000002287267 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0518756 0.00824545 0.0000000003234995 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18410078 chr11:65647288 11 65647288 CTSW Open sea 0.0024 None 0.00000000048 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0506213 0.00824599 0.0000000008523698 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0494263 0.00824648 0.0000000021003 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0482296 0.00824696 0.000000005076131 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea 0.0063 0.0011 0.0000000052 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.047242 0.00824735 0.0000000103529 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0471865 0.00824737 0.00000001077114 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19792802 chr11:65647270 11 65647270 CTSW Open sea 0.00016 None 0.000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea -0.0011 0.0002 0.000000025 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0452267 0.00824812 0.00000004244295 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.043532 0.00824874 0.0000001328895 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22178971 chr11:65645955 11 65645955 CTSW Open sea 0.0428295 0.008249 0.0000002107271 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea 0.0013 None 0.00000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08416661 chr11:65647279 11 65647279 CTSW Open sea 0.0012 None 0.00000028 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea 0.178423 0.0359779 0.0000007143756 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0909834 0.0186561 0.000001089191 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0390022 0.00825029 0.000002295508 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea -0.0384382 0.00825047 0.000003206724 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0381505 0.00825056 0.000003796435 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0380214 0.0082506 0.000004093684 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea 0.16274 0.0360647 0.000006450373 None 39706196_Hannah-M.-Smith_body_fat_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25470561 chr11:65646656 11 65646656 CTSW Open sea 0.004 None 0.0000078 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.163347 0.0366597 0.0000084116 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0412289 0.00930093 0.000009370422 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0402286 0.00912605 0.0000105019 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22178971 chr11:65645955 11 65645955 CTSW Open sea -0.260331 0.0591294 0.00001075368 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea -0.0357092 0.00825131 0.00001516719 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0820132 0.0189601 0.00001531395 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0354746 0.00825137 0.00001724931 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23483894 chr11:65646612 11 65646612 CTSW Open sea 0.0041 None 0.000024 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22178971 chr11:65645955 11 65645955 CTSW Open sea 0.0344255 0.00825168 0.00003037486 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22178971 chr11:65645955 11 65645955 CTSW Open sea -0.183253 0.0441241 0.00003294407 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01669108 chr11:65646791 11 65646791 CTSW Open sea 0.0011 None 0.000034 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 25424692 2020-09-15 Smoking EFO_0004318, EFO_0005671, EFO_0006527 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers None DNA methylation Smoking Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 442 1 Adults Both European cg01669108 chr11:65646791 11 65646791 CTSW Open sea -0.0085 0.00206 0.000043 None 25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers Battram T ARIES None 2020-08-20 Phospholipids to total lipids ratio in IDL EFO_0004639 None None DNA methylation Phospholipids to total lipids ratio in IDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 672 1 Adults Females European cg25470561 chr11:65646656 11 65646656 CTSW Open sea 0.197 0.048 0.000049 None Battram-T_phospholipids_to_total_lipids_ratio_in_idl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0377218 0.00928786 0.00004903098 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0332929 0.00825199 0.0000549905 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.03 0.0075 0.000057 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03887787 chr11:65647532 11 65647532 CTSW Open sea -0.0330148 0.00825207 0.00006344123 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.252177 0.0630887 0.00006435418 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0370521 0.00927918 0.00006555192 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea -0.0366024 0.0092479 0.00007596217 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg12476381 chr11:65649203 11 65649203 CTSW Open sea 0.99 0.249 0.000076 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCER2 protein levels (SeqId = 3291-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCER2 protein levels (SeqId = 3291-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor 774 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.71 0.18 0.00008 None Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0324116 0.00825223 0.00008618405 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 NTS protein levels (SeqId = 7857-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NTS protein levels (SeqId = 7857-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neurotensin/neuromedin N 774 1 Adults (18-65 years) Both European cg23483894 chr11:65646612 11 65646612 CTSW Open sea 0.813 0.207 0.000088 None Gadd-DA_nts_protein_levels__seqid___7857-22__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15229926 chr11:65648571 11 65648571 CTSW Open sea 0.0363021 0.00928555 0.00009289366 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg01669108 chr11:65646791 11 65646791 CTSW Open sea -0.0003029 7.72e-05 0.0000934 - 27717397_gestational_age_ultrasoundestimated_gestational_age Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01669108 chr11:65646791 11 65646791 CTSW Open sea None None 0.000096 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery