author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island 0.0021 0.00011 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore 0.0037 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.017 0.0011 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.022 0.0019 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore 0.0021 0.00021 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.013 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore -0.003 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0084 0.00025 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.031 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island 0.0019 0.000098 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.29456 0.00495 3.6e-126 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 2.2600000000000003e-123 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island 0.10748 0.00214 7.2e-113 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore 0.24998 0.00555 2e-104 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island 0.13475 0.0031 9.299999999999999e-102 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore - - 3.8700000000000005e-70 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13779795 chr9:139943636 9 139943636 ENTPD2 Island 0.10809 0.00472 5.4e-57 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island - - 1.8299999999999997e-54 - 23526956_clear_cell_renal_carcinoma Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.11598 0.0055 5.2e-52 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island 0.0013 None 1.4e-50 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore 0.06155 0.00356 4.0999999999999996e-41 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 1.0100000000000001e-27 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0807259 0.00822962 1.206745e-22 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island 0.16209 0.01471 3.2000000000000003e-22 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3195174 (gene symbol: MAN1B1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3195174 (gene symbol: MAN1B1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg14024893 chr9:139943146 9 139943146 ENTPD2 Island None None 3.2e-20 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3195174__gene_symbol__man1b1__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0722792 0.00823337 1.832613e-18 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0716407 0.00820872 2.883431e-18 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.071623 0.0082462 4.161687e-18 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0714274 0.00823548 4.639741e-18 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.24065 0.0283 1.73e-17 - 25650246_gestational_age Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17018517 chr9:139947922 9 139947922 ENTPD2 Island 0.02257 0.00247 8.8e-17 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.02 0.0025 4.4e-16 None 33450751_Mulder-RH_sex_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.03248 0.00367 5.7e-16 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.253264 0.0320121 0.000000000000002687449 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore - - 0.0000000000000326 - 26500701_sex_kora_f4 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.15417 0.0204 0.0000000000000365 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.060679 0.00824136 0.0000000000001897377 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0599233 0.00824173 0.0000000000003756485 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0602746 0.00830412 0.0000000000004113697 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0591873 0.0082421 0.000000000000724782 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0571066 0.00829526 0.000000000006045132 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0566284 0.00824332 0.000000000006697202 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0563689 0.00824344 0.000000000008346075 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg17018517 chr9:139947922 9 139947922 ENTPD2 Island 0.13992 0.0206 0.000000000011 - 25650246_gestational_age Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore 0.15079 0.0225 0.0000000000204 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0543431 0.00824437 0.00000000004501348 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore - - 0.0000000000495 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0544369 0.00829438 0.00000000005446742 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0535898 0.00824471 0.00000000008296855 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.013 0.0021 0.00000000035 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.0087 0.0014 0.00000000043 None 33450751_Mulder-RH_sex_discovery Shah S - 25249537 2014-09-23 Sex PATO_0000047 Replication Table S3 DNA methylation Sex Smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 445 1 79 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 0.000000000442 - 25249537_sex_replication Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.006 0.00097 0.00000000061 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0508239 0.0082459 0.0000000007300133 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island - - 0.000000000839 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0503658 0.00824609 0.000000001035355 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0499155 0.00830982 0.00000000193679 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0049 0.00076 0.0000000026 None 33564054_Kashima-K_gestational_age Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg25483003 chr9:139948856 9 139948856 ENTPD2 Island 0.025 0.00389 0.0000000047 None 32795589_Kyung-WK_eosinophilia_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.0054 0.00093 0.0000000089 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0466414 0.00812202 0.000000009508974 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.00060964 0.00010681 0.0000000148 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Bozack PRISM 34569420 Oct 22, 2021 Infant sex PATO_0001894 Cord blood Supplementary table 8 DNA methylation Infant sex Cell composition (reference free), Batch effects, Ancestry (other) M values None Illumina HumanMethylation450 cord blood None 179 1 Infants Both European, African, Other cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore None None 0.000000019 None 34569420_Bozack_infant_sex_cord_blood Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13779795 chr9:139943636 9 139943636 ENTPD2 Island 0.011 0.0019 0.000000022 None 33450751_Mulder-RH_sex_discovery Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg13247581 chr9:139948584 9 139948584 ENTPD2 Island 0.00349 6e-04 0.0000000282 - 23334450_rheumatoid_arthritis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore - - 0.0000000306 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.175887 0.031943 0.00000003714933 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Shah S - 25249537 2014-09-23 Sex PATO_0000047 Discovery Table S3 DNA methylation Sex Smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 815 1 70 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 0.0000000418 - 25249537_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.044716 0.00824831 0.00000006012787 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island 0.00078 None 0.000000068 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.178267 0.0330812 0.00000007186222 None 39706196_Hannah-M.-Smith_body_fat_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island 0.0039 0.00073 0.000000086 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.176131 0.0330061 0.00000009604966 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0439311 0.00831765 0.0000001298439 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island -0.004 0.00077 0.00000013 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13588040 chr9:139943864 9 139943864 ENTPD2 South shore 0.02471 0.00451 0.00000013 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0430547 0.00824892 0.0000001819199 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.0427525 0.00824902 0.0000002215601 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore None None 0.00000024 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.042372 0.00824916 0.000000283445 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.0423298 0.00830744 0.0000003523194 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore None None 0.00000052 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0415557 0.00828005 0.0000005261168 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0413053 0.00824953 0.0000005592869 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0413823 0.00833002 0.0000006846388 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0409655 0.00824964 0.0000006921317 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0391844 0.00794258 0.0000008167181 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0406498 0.00824975 0.0000008423832 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0390282 0.00796539 0.0000009699781 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0404081 0.00824983 0.000000978251 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.039544 0.0082941 0.000001881134 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 0.00000204 - 26500701_sex_kora_f3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17018517 chr9:139947922 9 139947922 ENTPD2 Island 0.004 0.00083 0.0000021 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0394458 0.0083191 0.000002140391 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0375846 0.00799871 0.000002640293 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.0386502 0.0082504 0.000002829555 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.0377444 0.00810707 0.00000325658 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0384723 0.00829453 0.000003543691 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore None None 0.000004 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore - - 0.00000445 - 26500701_sex_metaanalysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore None None 0.0000045 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.150756 0.0329877 0.000004909068 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07357 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07357 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0377055 0.0082507 0.000004917724 P07357 41361833_Josephine_Robertson_P07357_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07357 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07357 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0377942 0.00829173 0.000005204673 P07357 41361833_Josephine_Robertson_P07357_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07357 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07357 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0376377 0.00826485 0.000005307174 P07357 41361833_Josephine_Robertson_P07357_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07357 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07357 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14024893 chr9:139943146 9 139943146 ENTPD2 Island -0.0375412 0.00826532 0.000005616261 P07357 41361833_Josephine_Robertson_P07357_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0373331 0.00825082 0.000006093268 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore None None 0.0000066 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0373973 0.00831193 0.000006872436 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.037413 0.00831795 0.00000691652 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0374187 0.0083207 0.000006942674 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0360656 0.00803743 0.00000727122 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore -0.259543 0.0580851 0.000007931315 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore None None 0.0000088 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.00023169 5.25e-05 0.00001 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore -0.0363979 0.0082511 0.00001034956 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore 0.0362977 0.00825113 0.00001094598 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.0362183 0.00825115 0.00001144149 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0364014 0.00830316 0.0000117306 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.0029 0.00066 0.000013 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore - - 0.0000143 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0360057 0.00831466 0.00001498378 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 C1QTNF5 protein levels (SeqId = 7810-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C1QTNF5 protein levels (SeqId = 7810-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement C1q tumor necrosis factor-related protein 5 774 1 Adults (18-65 years) Both European cg08099672 chr9:139944162 9 139944162 ENTPD2 South shore 0.51 0.119 0.000017 None Gadd-DA_c1qtnf5_protein_levels__seqid___7810-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0345747 0.00807102 0.00001848902 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore 0.0046 0.001 0.000021 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0351004 0.00825148 0.00002114491 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0350608 0.00827336 0.0000227101 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0351845 0.00831762 0.00002349852 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0348039 0.00825157 0.00002481263 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island -0.0045 0.0011 0.000025 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore -0.0347671 0.00825158 0.00002530765 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0344603 0.00825167 0.00002981856 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.0343862 0.0082509 0.00003096248 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.034293 0.00823836 0.00003164344 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.0343197 0.00824883 0.00003192845 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.00048433 0.00011611 0.0000328 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0343395 0.00829476 0.00003493903 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island -0.0355998 0.00861414 0.00003604871 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.034366 0.00833007 0.00003719243 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0341669 0.00829171 0.00003799428 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.0333143 0.00809725 0.00003905306 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore -0.0062 0.0015 0.000045 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0336675 0.00825189 0.00004527962 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island 0.999059 0.2461 0.0000491 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0334437 0.00825195 0.00005086426 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SERPING1 protein levels (SeqId = 4479-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPING1 protein levels (SeqId = 4479-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Plasma protease C1 inhibitor 774 1 Adults (18-65 years) Both European cg13247581 chr9:139948584 9 139948584 ENTPD2 Island 0.57 0.141 0.000054 None Gadd-DA_serping1_protein_levels__seqid___4479-14__somascan_protein_measurement Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.00475 0.00118 0.000055 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 KRT20 protein levels (SeqId = 12975-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT20 protein levels (SeqId = 12975-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type I cytoskeletal 20 774 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore 1.14 0.284 0.000058 None Gadd-DA_krt20_protein_levels__seqid___12975-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0331608 0.00825203 0.00005886103 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14044120 chr9:139949577 9 139949577 ENTPD2 South shore -0.033106 0.00825205 0.00006054409 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.0330963 0.00825205 0.00006084613 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14136372 chr9:139946201 9 139946201 ENTPD2 North shore 0.0330783 0.00825205 0.00006141056 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04823796 chr9:139948927 9 139948927 ENTPD2 Island -0.0344988 0.00864026 0.00006561714 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 QPCT protein levels (SeqId = 7849-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QPCT protein levels (SeqId = 7849-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaminyl-peptide cyclotransferase 774 1 Adults (18-65 years) Both European cg00708215 chr9:139946509 9 139946509 ENTPD2 North shore 1.11 0.282 0.00008 None Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13981310 chr9:139949063 9 139949063 ENTPD2 South shore -0.0319249 0.00809351 0.00008033841 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0328568 0.00833374 0.00008097073 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13779795 chr9:139943636 9 139943636 ENTPD2 Island 0.0324606 0.00826508 0.00008624866 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 CMPK1 protein levels (SeqId = 18243-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CMPK1 protein levels (SeqId = 18243-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UMP-CMP kinase 774 1 Adults (18-65 years) Both European cg17018517 chr9:139947922 9 139947922 ENTPD2 Island 0.59 0.151 0.00009 None Gadd-DA_cmpk1_protein_levels__seqid___18243-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25483003 chr9:139948856 9 139948856 ENTPD2 Island -0.0324351 0.00830265 0.00009402799 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13779795 chr9:139943636 9 139943636 ENTPD2 Island 0.0322225 0.00825228 0.00009477232 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore -0.0324912 0.00832511 0.00009551598 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14295062 chr9:139949108 9 139949108 ENTPD2 South shore 0.81 0.208 0.000096 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model