author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0055 0.00027 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0017 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0021 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.022 0.0023 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea -0.014 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26538529 chr2:222437130 2 222437130 EPHA4 Island 0.00048 None 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26538529 chr2:222437130 2 222437130 EPHA4 Island 0.0014 None 1.3e-176 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea -0.62789 0.00687 8.4e-161 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea 0.54895 0.0072 5.3e-146 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19245120 chr2:222411535 2 222411535 EPHA4 Open sea 0.57774 0.00805 3.7e-141 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.62704 0.00903 1.7999999999999998e-138 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.44524 0.00745 1.9e-126 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.3972 0.00698 1.5e-122 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.26775 0.00494 9.800000000000001e-119 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.30555 0.00679 2.6e-104 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.2317 0.00552 4.8e-99 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05736236 chr2:222435214 2 222435214 EPHA4 North shore 0.00079 None 7.1e-95 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05736236 chr2:222435214 2 222435214 EPHA4 North shore -0.1368 0.00403 2.5999999999999997e-83 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea 0.08728 0.00261 3.1e-82 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16786808 chr2:222434497 2 222434497 EPHA4 North shore -0.29717 0.00899 1.9000000000000002e-81 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.24633 0.0084 4.6000000000000004e-73 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.16439 0.00583 2.3e-70 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18527574 chr2:222434303 2 222434303 EPHA4 North shore -0.20098 0.0076 4.1e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea - - 1.86e-65 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea - - 2.3e-61 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.130996 0.00818542 3.6778639999999996e-57 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.128614 0.008188 3.772795e-55 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.120274 0.00819663 2.0960839999999998e-48 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.112548 0.00820411 1.441928e-42 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.108532 0.0082078 1.0891820000000001e-39 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.104995 0.00821094 3.055442e-37 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.0991808 0.00821586 2.14121e-33 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea - - 2.37e-33 - 23526956_clear_cell_renal_carcinoma Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea -1.37175 0.08302 1.45e-28 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0896407 0.00822333 1.457728e-27 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.0894796 0.00822345 1.8076380000000002e-27 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0864217 0.00822568 9.968897e-26 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0861074 0.00822591 1.493605e-25 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0849458 0.00822673 6.570433e-25 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea -1.55308 0.11346 2.0499999999999999e-23 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.078003 0.00823141 3.0314099999999998e-21 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2600689 (gene symbol: EPHA4) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2600689 (gene symbol: EPHA4) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea None None 6.8e-21 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2600689__gene_symbol__epha4__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea - - 2.88e-20 - 24500968_pancreatic_ductal_adenocarcinoma Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19484328 chr2:222342867 2 222342867 EPHA4 Open sea 0.02271 0.00222 6.4e-20 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0748174 0.00823343 1.1459909999999999e-19 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea - - 1.45e-19 - 24500968_pancreatic_ductal_adenocarcinoma Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.26657 0.0305 2.37e-18 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0753323 0.00875233 8.245828e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.070846 0.00823582 8.605775e-18 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0702724 0.00823616 1.5752640000000002e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 2.5 0.29 3.2e-17 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg13231700 chr2:222435709 2 222435709 EPHA4 North shore 0.02991 0.0036 4.55e-17 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0712013 0.00869301 2.811379e-16 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05736236 chr2:222435214 2 222435214 EPHA4 North shore 0.00046 0.000057 6.7e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0706102 0.00873895 6.981914e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0664121 0.00823834 8.125779e-16 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0913458 0.0113343 8.267384e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.319836 0.0397438 8.968447e-16 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea -0.001 0.00013 0.0000000000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.236935 0.0295702 0.000000000000001190336 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.403401 0.0503983 0.000000000000001273667 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea -1.31313 0.13648 0.0000000000000024 - 25282492_fetal_vs_adult_liver Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13231700 chr2:222435709 2 222435709 EPHA4 North shore -0.0011 0.00013 0.0000000000000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18527574 chr2:222434303 2 222434303 EPHA4 North shore -0.034 0.0043 0.0000000000000033 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.064744 0.00823925 0.00000000000000417309 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0645649 0.00823934 0.000000000000004962751 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01446950 chr2:222435351 2 222435351 EPHA4 North shore -0.01554 0.00183 0.000000000000006 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea None None 0.0000000000000078 None 31789449_Dugue-P-A_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.063888 0.0082397 0.000000000000009511399 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.028 0.0037 0.000000000000012 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0633465 0.00823999 0.00000000000001592913 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 1.9 0.255 0.000000000000027 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.062749 0.0082403 0.00000000000002799726 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0625313 0.00824041 0.00000000000003434168 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0625263 0.00824042 0.00000000000003450333 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0622753 0.00824055 0.00000000000004362291 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10517814 chr2:222436149 2 222436149 EPHA4 Island 0.0124 0.00152 0.000000000000047 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0620896 0.00824064 0.00000000000005185619 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0620308 0.00824067 0.0000000000000547679 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0612523 0.00824107 0.0000000000001123931 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0612461 0.00824107 0.0000000000001130324 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.061167 0.00824111 0.0000000000001215353 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05736236 chr2:222435214 2 222435214 EPHA4 North shore 0.002 None 0.00000000000014 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.011 0.0015 0.00000000000015 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0608493 0.00824127 0.0000000000001624931 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.3005 0.0412 0.000000000000286 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.06022 0.00824159 0.0000000000002875828 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0601836 0.0082416 0.0000000000002971825 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0600168 0.00824169 0.0000000000003453617 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea -0.0005 0.000069 0.00000000000069 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0590579 0.00824216 0.0000000000008129294 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.36201 0.0505822 0.0000000000008568471 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0589712 0.0082422 0.0000000000008777235 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.217118 0.0303653 0.000000000000901071 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0588841 0.00824224 0.0000000000009479563 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0587985 0.00824229 0.000000000001022355 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0583769 0.00824249 0.000000000001480859 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0579951 0.00824267 0.000000000002066586 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0022 None 0.0000000000022 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.00586 0.00083 0.0000000000022 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0685111 0.00978783 0.000000000002677899 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.389113 0.0558281 0.000000000003287747 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24372550 chr2:222437040 2 222437040 EPHA4 Island 0.00032 0.000046 0.0000000000039 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0604333 0.00870851 0.000000000004097773 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.000043 0.0000062 0.0000000000041 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0568491 0.00824322 0.000000000005548891 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0563917 0.00824343 0.000000000008186974 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0559764 0.00824363 0.00000000001162283 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea 0.0087 0.0013 0.000000000012 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0883417 0.013022 0.00000000001213332 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0555687 0.00824381 0.00000000001635578 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16786808 chr2:222434497 2 222434497 EPHA4 North shore -0.035 0.0052 0.000000000018 None 33450751_Mulder-RH_sex_discovery Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg05736236 chr2:222435214 2 222435214 EPHA4 North shore -0.017 0.00232 0.000000000022 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0773673 0.0115979 0.0000000000263483 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.054777 0.00824418 0.00000000003153461 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -2.3 0.345 0.000000000033 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0546343 0.00824424 0.00000000003546038 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16786808 chr2:222434497 2 222434497 EPHA4 North shore -0.0542591 0.00824441 0.00000000004821217 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.00078631 0.00011834 0.0000000000488 - 27717397_gestational_age_ultrasoundestimated_gestational_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.199953 0.0304418 0.00000000005232278 None 39706196_Hannah-M.-Smith_body_fat_discovery Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.042 0.0057 0.000000000057 None 32795589_Kyung-WK_eosinophilia_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -1.4 0.217 0.000000000063 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0536909 0.00824466 0.00000000007646902 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0536309 0.00824469 0.00000000008025974 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0560851 0.00868484 0.0000000001095687 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea -0.026 0.00368 0.00000000012 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0530664 0.00824494 0.0000000001262705 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24372550 chr2:222437040 2 222437040 EPHA4 Island 0.00918 0.00136 0.00000000015 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg01446950 chr2:222435351 2 222435351 EPHA4 North shore 0.00902 0.0014 0.000000000175 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0526486 0.00824512 0.000000000176073 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.0526339 0.00824513 0.0000000001781245 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.0525846 0.00824515 0.0000000001852245 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0520389 0.00824538 0.0000000002846888 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 1.9 0.295 0.0000000003 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08728892 chr2:222437081 2 222437081 EPHA4 Island -0.00005 0.0000079 0.00000000031 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0517556 0.00824551 0.0000000003552797 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea None None 0.00000000045 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0514312 0.00824564 0.0000000004571802 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0512435 0.00824572 0.0000000005286042 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.051191 0.00824575 0.0000000005504931 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0587519 0.00946891 0.0000000005627076 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02700328 chr2:222432475 2 222432475 EPHA4 North shelf 0.02917 0.00448 0.00000000061 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10517814 chr2:222436149 2 222436149 EPHA4 Island 0.00036 0.000058 0.00000000066 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0718849 0.0116795 0.0000000007714164 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg02700328 chr2:222432475 2 222432475 EPHA4 North shelf - - 0.000000000792 - 26857698_primary_sjogrens_syndrome_whole_blood Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0694409 0.0113802 0.000000001074492 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0076 0.0012 0.0000000011 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea -0.0501958 0.00824616 0.000000001177879 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea - - 0.00000000155 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0497936 0.00824633 0.00000000159527 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0496406 0.00824639 0.000000001789289 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0520931 0.00868906 0.000000002079409 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island 0.00781 0.0013 0.00000000216 - 23334450_rheumatoid_arthritis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.0097 0.0016 0.0000000022 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0574475 0.00964194 0.000000002610614 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0486451 0.0082468 0.000000003745144 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0485064 0.00824685 0.000000004146293 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0011 None 0.0000000045 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0483914 0.0082469 0.000000004510531 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0483757 0.0082469 0.000000004562583 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0482274 0.00824696 0.000000005084185 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0481362 0.008247 0.00000000543314 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0479101 0.00824709 0.000000006402008 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0479065 0.00824709 0.00000000641914 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0474774 0.00824726 0.000000008746789 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0671997 0.0116737 0.000000008759814 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea 0.0011 0.00019 0.0000000088 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.00079882 0.00013803 0.00000000939 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.047318 0.00824732 0.000000009805274 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0750637 0.0130877 0.000000009917444 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0552829 0.00964026 0.000000009967456 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0471944 0.00824737 0.00000001071064 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0471043 0.00824741 0.00000001142193 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0468933 0.00824749 0.00000001327087 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0663441 0.0116884 0.00000001404451 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_4 Yang BZ - 23332324 2013-02-01 Child abuse - - Appendix B DNA methylation Child abuse Sex, age and ethnicity Beta values - Illumina HumanMethylation450 Saliva - 192 1 10 Both European,African,Admixed,Other cg05736236 chr2:222435214 2 222435214 EPHA4 North shore - - 0.000000015 - 23332324_child_abuse Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.055 0.00896 0.000000015 None 32795589_Kyung-WK_eosinophilia_discovery Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg08787401 chr2:222383520 2 222383520 EPHA4 Open sea -0.1591 0.0281 0.0000000158 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0466208 0.00824759 0.00000001609269 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0464833 0.00824765 0.00000001772984 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg08728892 chr2:222437081 2 222437081 EPHA4 Island 0.00442 8e-04 0.0000000193 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.0462463 0.00824774 0.00000002094029 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0531863 0.00948603 0.00000002098208 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0461965 0.00824776 0.00000002168269 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0495969 0.00888138 0.00000002387199 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0496384 0.00889903 0.00000002476532 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.045987 0.00824784 0.0000000250975 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0458999 0.00824787 0.00000002666418 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0644615 0.0115897 0.00000002713992 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.046 0.00759 0.00000003 None 32795589_Kyung-WK_eosinophilia_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.019 0.0034 0.000000032 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0490314 0.00887465 0.00000003353232 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23317907 chr2:222437071 2 222437071 EPHA4 Island -0.00007 0.000013 0.000000034 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0455411 0.00824801 0.00000003418842 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0453584 0.00824807 0.00000003877293 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.166913 0.0303599 0.00000003899708 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0637571 0.0115987 0.00000003928853 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0453127 0.00824809 0.00000004001035 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.045243 0.00824812 0.00000004197151 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0461359 0.00841737 0.00000004298323 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.240355 0.0440302 0.00000004857669 None 39706196_Hannah-M.-Smith_bmi_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -1.8 0.336 0.000000054 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -2.4 0.447 0.000000057 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01446950 chr2:222435351 2 222435351 EPHA4 North shore 0.00016 0.000029 0.000000059 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0624394 0.0115309 0.00000006227267 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.052109 0.00965621 0.00000006903928 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15808558 chr2:222437611 2 222437611 EPHA4 Island 0.0002 0.000037 0.000000071 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.013 0.0025 0.000000073 None 33450751_Mulder-RH_sex_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0036 0.00063 0.000000077 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0443496 0.00824845 0.00000007701614 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Shah S - 25249537 2014-09-23 Sex PATO_0000047 Replication Table S3 DNA methylation Sex Smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 445 1 79 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea - - 0.0000000778 - 25249537_sex_replication Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00081574 chr2:222437836 2 222437836 EPHA4 Island 0.00788 0.00141 0.000000078 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.044313 0.00824846 0.00000007893385 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.053254 0.00991447 0.00000007934731 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg08625382 chr2:222437387 2 222437387 EPHA4 Island 0.01072 0.002 0.0000000806 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0441831 0.00824851 0.00000008612895 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0441765 0.00824851 0.00000008651607 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0440432 0.00824856 0.00000009459415 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.212939 0.0398996 0.00000009569244 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0440068 0.00824857 0.00000009692245 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0439927 0.00824858 0.00000009783958 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.043987 0.00824858 0.00000009820934 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0530324 0.00994732 0.00000009894267 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0439508 0.00824859 0.000000100614 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0467106 0.00878825 0.0000001081485 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0462627 0.00870445 0.0000001083185 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 RAMP3 protein levels (SeqId = 15437-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAMP3 protein levels (SeqId = 15437-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor activity-modifying protein 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.6 0.114 0.00000011 None Gadd-DA_ramp3_protein_levels__seqid___15437-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0437761 0.00824866 0.0000001130316 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.016 0.003 0.000000118 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.273229 0.0517893 0.0000001337852 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0610744 0.0115902 0.0000001387339 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg05499262 chr2:222437089 2 222437089 EPHA4 Island 0.00419 8e-04 0.000000139 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0434478 0.00824877 0.0000001404907 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0457446 0.00868575 0.000000140921 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0433589 0.00824881 0.000000148979 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.060561 0.0115858 0.0000001744758 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Shah S - 25249537 2014-09-23 Sex PATO_0000047 Discovery Table S3 DNA methylation Sex Smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 815 1 70 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea - - 0.00000018 - 25249537_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0429491 0.00824895 0.000000194921 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.051 0.0099 0.00000023 None Robert-F-Hillary_Incident_COPD_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.00084 None 0.00000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0436288 0.00844312 0.0000002405095 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0484408 0.00937518 0.0000002411102 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0674862 0.0130667 0.0000002439333 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0447771 0.00868034 0.0000002522501 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0584862 0.0113637 0.0000002684829 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0067 0.0013 0.00000027 - 27651444_smoking_current_vs_never_smoking Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26538529 chr2:222437130 2 222437130 EPHA4 Island 0.00405 0.00076 0.00000027 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0424311 0.00824914 0.0000002728459 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0423117 0.00824918 0.0000002946796 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -1.1 0.214 0.00000031 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0067 0.0013 0.00000032 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13231700 chr2:222435709 2 222435709 EPHA4 North shore 0.01098 0.00207 0.00000032 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 FTL protein levels (SeqId = 15324-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTL protein levels (SeqId = 15324-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin light chain 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -1.09 0.214 0.00000032 None Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KRT7 protein levels (SeqId = 11383-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT7 protein levels (SeqId = 11383-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type II cytoskeletal 7 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.58 0.114 0.00000034 None Gadd-DA_krt7_protein_levels__seqid___11383-41__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0452987 0.00890096 0.0000003640481 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0592747 0.0116773 0.0000003900274 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0587214 0.0115757 0.0000003967451 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 HS3ST3B1 protein levels (SeqId = 6986-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HS3ST3B1 protein levels (SeqId = 6986-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.58 0.114 0.00000042 None Gadd-DA_hs3st3b1_protein_levels__seqid___6986-17__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0417313 0.00824938 0.0000004271826 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.032 0.00628 0.00000043 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0417201 0.00824938 0.00000043024 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0661439 0.0131006 0.0000004496516 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea None None 0.00000053 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0582564 0.0116174 0.0000005377178 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0413542 0.00824951 0.000000542311 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0413306 0.00824952 0.0000005504537 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0579342 0.0115693 0.0000005576051 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0412866 0.00824953 0.0000005659032 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0411011 0.00824959 0.0000006358396 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0410892 0.0082496 0.000000640564 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0410158 0.00824962 0.0000006706968 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 C20orf173 protein levels (SeqId = 7046-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C20orf173 protein levels (SeqId = 7046-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C20orf173 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.56 0.114 0.00000073 None Gadd-DA_c20orf173_protein_levels__seqid___7046-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HOGA1 protein levels (SeqId = 10024-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HOGA1 protein levels (SeqId = 10024-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.56 0.114 0.00000082 None Gadd-DA_hoga1_protein_levels__seqid___10024-44__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0406864 0.00824973 0.000000823503 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0459793 0.00932661 0.0000008317128 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.191128 0.0389333 0.0000009232492 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0404648 0.00824981 0.0000009445918 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27132396 chr2:222438339 2 222438339 EPHA4 Island 0.00037 0.000076 0.000001 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0402663 0.00824988 0.000001067444 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0401778 0.0082499 0.000001127059 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.0401221 0.00824992 0.000001166216 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.040024 0.00824996 0.000001238382 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0633957 0.0130692 0.000001242568 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0399766 0.00824997 0.000001274749 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg08625382 chr2:222437387 2 222437387 EPHA4 Island - - 0.00000128 - 26500701_sex_kora_f3 Gadd DA Generation Scotland 35945220 31/07/2022 SYN3 protein levels (SeqId = 7199-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYN3 protein levels (SeqId = 7199-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synapsin-3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.55 0.114 0.0000013 None Gadd-DA_syn3_protein_levels__seqid___7199-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0479204 0.00990433 0.000001322689 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0432474 0.00894352 0.000001340853 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0449607 0.00932228 0.000001428867 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.270024 0.0559969 0.000001432482 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0558567 0.0115852 0.000001440025 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.039741 0.00825005 0.000001471457 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0559107 0.0116398 0.000001575474 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ADAM10 protein levels (SeqId = 8654-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAM10 protein levels (SeqId = 8654-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.55 0.114 0.0000016 None Gadd-DA_adam10_protein_levels__seqid___8654-13__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.039562 0.00825011 0.000001640017 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0408318 0.00851495 0.00000164018 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0461474 0.00962938 0.000001664534 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0395111 0.00825012 0.000001691227 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.025 0.00526 0.0000018 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0394022 0.00825016 0.000001806102 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0394001 0.00825016 0.000001808378 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0393746 0.00825017 0.000001836354 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0393392 0.00825018 0.000001875877 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0393228 0.00825019 0.000001894446 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10517814 chr2:222436149 2 222436149 EPHA4 Island 0.00036 None 0.000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0392053 0.00825022 0.000002032969 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0525088 0.0110611 0.000002082375 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 MUC1 protein levels (SeqId = 9176-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MUC1 protein levels (SeqId = 9176-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mucin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.54 0.114 0.0000021 None Gadd-DA_muc1_protein_levels__seqid___9176-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0422715 0.00891334 0.000002130822 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.039112 0.00825025 0.000002149822 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.00016136 3.41e-05 0.00000217 - 27843151_alcohol_consumption_per_day_european_ancestry Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.264401 0.0558268 0.000002196012 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.053 0.01129 0.0000022 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0032 0.00065 0.0000023 None 33564054_Kashima-K_gestational_age Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea None None 0.0000023 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0413846 0.00875657 0.00000230971 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0389387 0.00825031 0.000002384199 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.0135 0.0029 0.0000024 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0374755 0.0079436 0.000002407309 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.014 0.003 0.00000241 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.011 0.002 0.00000247 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Gadd DA Generation Scotland 35945220 31/07/2022 CPD protein levels (SeqId = 7917-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPD protein levels (SeqId = 7917-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase D 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.53 0.114 0.0000025 None Gadd-DA_cpd_protein_levels__seqid___7917-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DHX38 protein levels (SeqId = 13645-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DHX38 protein levels (SeqId = 13645-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.53 0.114 0.0000025 None Gadd-DA_dhx38_protein_levels__seqid___13645-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.0387997 0.00825035 0.000002589692 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0451469 0.00960972 0.000002650502 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0386906 0.00825039 0.000002762798 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0416396 0.00889527 0.00000287899 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0385982 0.00825042 0.000002917957 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 C9 protein levels (SeqId = 3060-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C9 protein levels (SeqId = 3060-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement component C9 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.99 0.211 0.000003 None Gadd-DA_c9_protein_levels__seqid___3060-43__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0384902 0.00825045 0.00000311004 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0543816 0.0116754 0.000003224288 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.223121 0.0479747 0.000003330771 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19245120 chr2:222411535 2 222411535 EPHA4 Open sea 0.014 0.0031 0.0000034 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 LRTM2 protein levels (SeqId = 8906-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRTM2 protein levels (SeqId = 8906-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat and transmembrane domain-containing protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.53 0.11 0.0000034 None Gadd-DA_lrtm2_protein_levels__seqid___8906-60__somascan_protein_measurement Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea - - 0.00000341 - 26500701_sex_kora_f3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0412698 0.00889041 0.000003479412 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island 0.00024 0.000052 0.0000035 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.053759 0.0115869 0.000003520351 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0459224 0.00990684 0.000003592763 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0381616 0.00825056 0.000003771778 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27132396 chr2:222438339 2 222438339 EPHA4 Island 0.0023 0.0005 0.0000039 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 BTG2 protein levels (SeqId = 11325-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BTG2 protein levels (SeqId = 11325-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein BTG2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000039 None Gadd-DA_btg2_protein_levels__seqid___11325-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0410452 0.00888938 0.000003920142 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0380939 0.00825058 0.000003923984 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.044 0.0096 0.000004 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 EGLN1 protein levels (SeqId = 9901-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EGLN1 protein levels (SeqId = 9901-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Egl nine homolog 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.000004 None Gadd-DA_egln1_protein_levels__seqid___9901-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island 0.0389377 0.00844142 0.000004008503 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.00438 0.00095 0.0000041 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.040073 0.00869962 0.000004133666 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.014 0.003 0.0000042 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Gadd DA Generation Scotland 35945220 31/07/2022 ANGPTL1 protein levels (SeqId = 9092-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANGPTL1 protein levels (SeqId = 9092-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Angiopoietin-related protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000043 None Gadd-DA_angptl1_protein_levels__seqid___9092-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0379046 0.00825064 0.000004381517 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 C3orf18 protein levels (SeqId = 6994-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C3orf18 protein levels (SeqId = 6994-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C3orf18 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000044 None Gadd-DA_c3orf18_protein_levels__seqid___6994-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDIA4 protein levels (SeqId = 7146-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDIA4 protein levels (SeqId = 7146-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase A4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000044 None Gadd-DA_pdia4_protein_levels__seqid___7146-16__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02700328 chr2:222432475 2 222432475 EPHA4 North shelf -0.011 0.0025 0.0000045 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 VSTM4 protein levels (SeqId = 7242-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VSTM4 protein levels (SeqId = 7242-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: V-set and transmembrane domain-containing protein 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000045 None Gadd-DA_vstm4_protein_levels__seqid___7242-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0378315 0.00825066 0.000004571486 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.202203 0.0441422 0.000004666359 None 39706196_Hannah-M.-Smith_body_fat_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.0079 0.0016 0.0000047 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea 0.0377805 0.00825068 0.000004708567 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0506188 0.0110601 0.000004762503 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0013 None 0.0000048 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 PF4V1 protein levels (SeqId = 5663-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PF4V1 protein levels (SeqId = 5663-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet factor 4 variant 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.114 0.0000048 None Gadd-DA_pf4v1_protein_levels__seqid___5663-18__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0377402 0.00825069 0.00000481999 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0377326 0.00825069 0.00000484107 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0447807 0.00979471 0.000004872017 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 CD3E protein levels (SeqId = 18870-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD3E protein levels (SeqId = 18870-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-cell surface glycoprotein CD3 epsilon chain 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.52 0.113 0.0000049 None Gadd-DA_cd3e_protein_levels__seqid___18870-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.053006 0.0116061 0.00000498585 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06301161 chr2:222302347 2 222302347 EPHA4 Open sea -0.0376619 0.00825071 0.000005042976 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0396575 0.00870868 0.000005311063 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea -0.0375236 0.00825076 0.000005461713 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0375105 0.00825076 0.000005503038 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.058848 0.0129476 0.00000553523 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.0374409 0.00825078 0.000005727845 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10871883 chr2:222290943 2 222290943 EPHA4 Open sea -0.179446 0.0395509 0.000005742269 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0510602 0.0112601 0.000005816911 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17846785 chr2:222436499 2 222436499 EPHA4 Island -0.000085 0.000019 0.000006 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 IL10RA protein levels (SeqId = 10344-334) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL10RA protein levels (SeqId = 10344-334) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-10 receptor subunit alpha 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.000006 None Gadd-DA_il10ra_protein_levels__seqid___10344-334__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0403023 0.00890398 0.000006049153 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ST8SIA2 protein levels (SeqId = 7920-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST8SIA2 protein levels (SeqId = 7920-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-2,8-sialyltransferase 8B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.0000063 None Gadd-DA_st8sia2_protein_levels__seqid___7920-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SERPINA12 protein levels (SeqId = 6551-94) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPINA12 protein levels (SeqId = 6551-94) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serpin A12 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.113 0.0000064 None Gadd-DA_serpina12_protein_levels__seqid___6551-94__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.235016 0.0521364 0.000006595732 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0391601 0.00869602 0.000006744759 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0433371 0.0096339 0.00000689937 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0420322 0.00935344 0.000007051042 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18527574 chr2:222434303 2 222434303 EPHA4 North shore -0.0370069 0.00825092 0.000007340521 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ACLY protein levels (SeqId = 12700-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACLY protein levels (SeqId = 12700-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATP-citrate synthase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.0000074 None Gadd-DA_acly_protein_levels__seqid___12700-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RERG protein levels (SeqId = 17822-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RERG protein levels (SeqId = 17822-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related and estrogen-regulated growth inhibitor 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.0000078 None Gadd-DA_rerg_protein_levels__seqid___17822-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIAA0319L protein levels (SeqId = 13698-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA0319L protein levels (SeqId = 13698-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dyslexia-associated protein KIAA0319-like protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.11 0.0000078 None Gadd-DA_kiaa0319l_protein_levels__seqid___13698-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0513329 0.0114785 0.000007804824 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 INSL6 protein levels (SeqId = 5754-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 INSL6 protein levels (SeqId = 5754-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like peptide INSL6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.11 0.0000079 None Gadd-DA_insl6_protein_levels__seqid___5754-76__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0368761 0.00825096 0.00000790605 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0368733 0.00825096 0.000007918645 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HTR2A protein levels (SeqId = 13556-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HTR2A protein levels (SeqId = 13556-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 5-hydroxytryptamine receptor 2A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.000008 None Gadd-DA_htr2a_protein_levels__seqid___13556-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.038713 0.00867012 0.000008062555 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea -0.61 0.138 0.0000082 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.039 0.00883 0.0000082 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19484328 chr2:222342867 2 222342867 EPHA4 Open sea -0.0004 0.00009 0.0000083 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0392139 0.00879768 0.000008361519 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 UBD protein levels (SeqId = 17772-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBD protein levels (SeqId = 17772-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin D 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.0000084 None Gadd-DA_ubd_protein_levels__seqid___17772-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0367498 0.00825099 0.000008491522 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0076 0.0017 0.0000086 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 RELB protein levels (SeqId = 11464-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RELB protein levels (SeqId = 11464-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription factor RelB 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.0000087 None Gadd-DA_relb_protein_levels__seqid___11464-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COA3 protein levels (SeqId = 7888-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COA3 protein levels (SeqId = 7888-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytochrome c oxidase assembly factor 3 homolog, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.51 0.114 0.0000088 None Gadd-DA_coa3_protein_levels__seqid___7888-58__somascan_protein_measurement Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg16786808 chr2:222434497 2 222434497 EPHA4 North shore 0.018 0.004 0.00000884 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Gadd DA Generation Scotland 35945220 31/07/2022 SPTLC2 protein levels (SeqId = 7267-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPTLC2 protein levels (SeqId = 7267-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine palmitoyltransferase 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.0000089 None Gadd-DA_sptlc2_protein_levels__seqid___7267-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CEACAM19 protein levels (SeqId = 7048-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CEACAM19 protein levels (SeqId = 7048-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carcinoembryonic antigen-related cell adhesion molecule 19 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.0000091 None Gadd-DA_ceacam19_protein_levels__seqid___7048-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PCDHB1 protein levels (SeqId = 9941-70) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PCDHB1 protein levels (SeqId = 9941-70) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protocadherin beta-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.0000092 None Gadd-DA_pcdhb1_protein_levels__seqid___9941-70__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0366008 0.00825104 0.000009235444 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.044027 0.00992739 0.000009278229 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Battram T ARIES None 2020-08-20 18:2 linoleic acid EFO_0006807 None None DNA methylation 18:2 linoleic acid Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 672 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.23 0.051 0.0000095 None Battram-T_18_2_linoleic_acid Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08787401 chr2:222383520 2 222383520 EPHA4 Open sea -0.00713 0.00157 0.0000095 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.0374011 0.00844642 0.000009577937 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 SEPTIN10 protein levels (SeqId = 12690-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SEPTIN10 protein levels (SeqId = 12690-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Septin-10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.0000096 None Gadd-DA_septin10_protein_levels__seqid___12690-33__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.190609 0.0430595 0.000009626826 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.036503 0.00825107 0.000009757384 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0364956 0.00825107 0.000009797798 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.0439158 0.00992872 0.000009799207 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09980780 chr2:222294689 2 222294689 EPHA4 Open sea -0.036495 0.00825107 0.000009801114 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0364944 0.00825107 0.000009804627 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.038473 0.00869845 0.0000098054 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10871883 chr2:222290943 2 222290943 EPHA4 Open sea -0.175274 0.0396426 0.000009868666 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0368199 0.00832858 0.000009899088 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0392214 0.00887265 0.000009919076 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Battram T GEO 27886173 2020-09-15 Ulcerative colitis EFO_0000729 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Ulcerative colitis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 163 1 Adults Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0383 0.00838 0.00001 None 27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Gadd DA Generation Scotland 35945220 31/07/2022 NPPB protein levels (SeqId = 16751-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPPB protein levels (SeqId = 16751-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Natriuretic peptides B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.00001 None Gadd-DA_nppb_protein_levels__seqid___16751-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SERF2 protein levels (SeqId = 18274-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERF2 protein levels (SeqId = 18274-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small EDRK-rich factor 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.00001 None Gadd-DA_serf2_protein_levels__seqid___18274-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACADS protein levels (SeqId = 17393-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACADS protein levels (SeqId = 17393-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.00001 None Gadd-DA_acads_protein_levels__seqid___17393-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HK1 protein levels (SeqId = 13131-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HK1 protein levels (SeqId = 13131-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hexokinase-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.00001 None Gadd-DA_hk1_protein_levels__seqid___13131-5__somascan_protein_measurement Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.013 0.003 0.0000108 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02700328 chr2:222432475 2 222432475 EPHA4 North shelf -0.0017 0.00038 0.000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.00038 None 0.000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T ARIES None 2020-08-20 Omega 6 fatty acids EFO_0005680 None None DNA methylation Omega 6 fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 672 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.194 0.044 0.000011 None Battram-T_omega_6_fatty_acids Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.0132 0.003 0.000011 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.079 0.0181 0.000011 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27132396 chr2:222438339 2 222438339 EPHA4 Island 0.00858 0.0019 0.000011 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 CDKN3 protein levels (SeqId = 14178-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDKN3 protein levels (SeqId = 14178-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinase inhibitor 3 774 1 Adults (18-65 years) Both European cg02754631 chr2:222290791 2 222290791 EPHA4 Open sea -0.63 0.144 0.000011 None Gadd-DA_cdkn3_protein_levels__seqid___14178-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANXA8 protein levels (SeqId = 18290-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANXA8 protein levels (SeqId = 18290-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Annexin A8 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_anxa8_protein_levels__seqid___18290-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SERF1A protein levels (SeqId = 7842-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERF1A protein levels (SeqId = 7842-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small EDRK-rich factor 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_serf1a_protein_levels__seqid___7842-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL1RAPL2 protein levels (SeqId = 5082-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL1RAPL2 protein levels (SeqId = 5082-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: X-linked interleukin-1 receptor accessory protein-like 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_il1rapl2_protein_levels__seqid___5082-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MSR1 protein levels (SeqId = 11207-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MSR1 protein levels (SeqId = 11207-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Macrophage scavenger receptor types I and II 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_msr1_protein_levels__seqid___11207-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RMI1 protein levels (SeqId = 13926-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RMI1 protein levels (SeqId = 13926-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RecQ-mediated genome instability protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_rmi1_protein_levels__seqid___13926-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSMB5 protein levels (SeqId = 12580-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMB5 protein levels (SeqId = 12580-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome subunit beta type-5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.113 0.000011 None Gadd-DA_psmb5_protein_levels__seqid___12580-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMIM13 protein levels (SeqId = 13452-113) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMIM13 protein levels (SeqId = 13452-113) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small integral membrane protein 13 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_smim13_protein_levels__seqid___13452-113__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKAP7 protein levels (SeqId = 18399-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKAP7 protein levels (SeqId = 18399-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: A-kinase anchor protein 7 isoforms alpha and beta 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000011 None Gadd-DA_akap7_protein_levels__seqid___18399-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0362382 0.00825115 0.00001131531 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0381367 0.00868356 0.00001131876 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea -0.0362099 0.00825116 0.00001149512 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0391086 0.00891329 0.00001153665 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.0361974 0.00825116 0.00001157568 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19831186 chr2:222312142 2 222312142 EPHA4 Open sea 0.0365284 0.00833152 0.00001171385 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08625382 chr2:222437387 2 222437387 EPHA4 Island -0.00904 0.00201 0.000012 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19484328 chr2:222342867 2 222342867 EPHA4 Open sea 0.0038 0.00086 0.000012 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ECE1 protein levels (SeqId = 8767-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ECE1 protein levels (SeqId = 8767-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endothelin-converting enzyme 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000012 None Gadd-DA_ece1_protein_levels__seqid___8767-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD200R1L protein levels (SeqId = 8980-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD200R1L protein levels (SeqId = 8980-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cell surface glycoprotein CD200 receptor 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.11 0.000012 None Gadd-DA_cd200r1l_protein_levels__seqid___8980-19__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0360763 0.0082512 0.00001238222 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0360311 0.00825121 0.00001269659 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0360099 0.00825122 0.00001284632 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea 0.028 0.0064 0.000013 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 TRIL protein levels (SeqId = 6527-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TRIL protein levels (SeqId = 6527-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: TLR4 interactor with leucine rich repeats 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000013 None Gadd-DA_tril_protein_levels__seqid___6527-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RFNG protein levels (SeqId = 7203-125) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RFNG protein levels (SeqId = 7203-125) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,3-N-acetylglucosaminyltransferase radical fringe 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.5 0.114 0.000013 None Gadd-DA_rfng_protein_levels__seqid___7203-125__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NRBP1 protein levels (SeqId = 12616-45) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NRBP1 protein levels (SeqId = 12616-45) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear receptor-binding protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.494 0.114 0.000013 None Gadd-DA_nrbp1_protein_levels__seqid___12616-45__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLC3A1 protein levels (SeqId = 9000-177) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLC3A1 protein levels (SeqId = 9000-177) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neutral and basic amino acid transport protein rBAT 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000013 None Gadd-DA_slc3a1_protein_levels__seqid___9000-177__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0387696 0.00889622 0.00001321575 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0358881 0.00825125 0.00001374277 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0358806 0.00825125 0.00001379945 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10517814 chr2:222436149 2 222436149 EPHA4 Island 0.0012 None 0.000014 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.035 0.00794 0.000014 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 ANP32A protein levels (SeqId = 13073-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANP32A protein levels (SeqId = 13073-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acidic leucine-rich nuclear phosphoprotein 32 family member A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000014 None Gadd-DA_anp32a_protein_levels__seqid___13073-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DGCR2 protein levels (SeqId = 8055-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DGCR2 protein levels (SeqId = 8055-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integral membrane protein DGCR2/IDD 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.494 0.114 0.000014 None Gadd-DA_dgcr2_protein_levels__seqid___8055-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TCL1A protein levels (SeqId = 17210-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TCL1A protein levels (SeqId = 17210-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-cell leukemia/lymphoma protein 1A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000014 None Gadd-DA_tcl1a_protein_levels__seqid___17210-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0386979 0.00891071 0.00001415931 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0357976 0.00825128 0.00001444642 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.035746 0.00825129 0.00001486287 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island 0.0366814 0.00846742 0.00001486979 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16786808 chr2:222434497 2 222434497 EPHA4 North shore -0.0357397 0.0082513 0.00001491486 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ACHE protein levels (SeqId = 15553-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACHE protein levels (SeqId = 15553-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acetylcholinesterase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000015 None Gadd-DA_ache_protein_levels__seqid___15553-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FATE1 protein levels (SeqId = 7740-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FATE1 protein levels (SeqId = 7740-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fetal and adult testis-expressed transcript protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000015 None Gadd-DA_fate1_protein_levels__seqid___7740-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ABCC6 protein levels (SeqId = 8935-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ABCC6 protein levels (SeqId = 8935-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Multidrug resistance-associated protein 6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000015 None Gadd-DA_abcc6_protein_levels__seqid___8935-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 OLFM3 protein levels (SeqId = 10643-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OLFM3 protein levels (SeqId = 10643-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Noelin-3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000015 None Gadd-DA_olfm3_protein_levels__seqid___10643-16__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0356847 0.00825131 0.0000153729 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01446950 chr2:222435351 2 222435351 EPHA4 North shore 0.0359922 0.00833698 0.00001590753 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.168466 0.0390286 0.00001594161 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0403771 0.00935544 0.00001599997 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 TNFSF4 protein levels (SeqId = 2839-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFSF4 protein levels (SeqId = 2839-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor ligand superfamily member 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_tnfsf4_protein_levels__seqid___2839-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GKN1 protein levels (SeqId = 15374-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GKN1 protein levels (SeqId = 15374-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gastrokine-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_gkn1_protein_levels__seqid___15374-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL25A1 protein levels (SeqId = 7006-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL25A1 protein levels (SeqId = 7006-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(XXV) chain 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_col25a1_protein_levels__seqid___7006-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NR1H4 protein levels (SeqId = 8946-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NR1H4 protein levels (SeqId = 8946-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bile acid receptor 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_nr1h4_protein_levels__seqid___8946-38__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAT5B protein levels (SeqId = 16551-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAT5B protein levels (SeqId = 16551-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal transducer and activator of transcription 5B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_stat5b_protein_levels__seqid___16551-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGB protein levels (SeqId = 18890-227) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGB protein levels (SeqId = 18890-227) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibrinogen beta chain 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000016 None Gadd-DA_fgb_protein_levels__seqid___18890-227__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SIGLEC8 protein levels (SeqId = 7864-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIGLEC8 protein levels (SeqId = 7864-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialic acid-binding Ig-like lectin 8 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.11 0.000016 None Gadd-DA_siglec8_protein_levels__seqid___7864-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0355857 0.00825134 0.0000162315 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.0355742 0.00825135 0.00001633401 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0355256 0.00825136 0.00001677488 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LILRA4 protein levels (SeqId = 8299-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LILRA4 protein levels (SeqId = 8299-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte immunoglobulin-like receptor subfamily A member 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000017 None Gadd-DA_lilra4_protein_levels__seqid___8299-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPC protein levels (SeqId = 11429-80) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPC protein levels (SeqId = 11429-80) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoproteins C1/C2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000017 None Gadd-DA_hnrnpc_protein_levels__seqid___11429-80__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0412837 0.00960064 0.00001718212 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.0354314 0.00825139 0.00001766197 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.042499 0.00990218 0.00001783036 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_3 Domingo-Relloso A Strong Heart Study 32484362 2020-06-02 Smoking EFO_0004318, EFO_0005671, EFO_0006527 Current vs never Table S2 DNA methylation Smoking Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs) M Values None Illumina HumanMethylationEPIC Whole blood None 2325 1 Adults Both Unclear cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.047 0.011 0.000018 None 32484362_Domingo-Relloso-A_smoking_current_vs_never Gadd DA Generation Scotland 35945220 31/07/2022 NAALADL1 protein levels (SeqId = 17505-125) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAALADL1 protein levels (SeqId = 17505-125) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aminopeptidase NAALADL1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000018 None Gadd-DA_naaladl1_protein_levels__seqid___17505-125__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FREM2 protein levels (SeqId = 7246-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FREM2 protein levels (SeqId = 7246-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: FRAS1-related extracellular matrix protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000018 None Gadd-DA_frem2_protein_levels__seqid___7246-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0559945 0.0130682 0.00001840857 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0355243 0.00829207 0.0000184629 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.01 0.002 0.0000185 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16786808 chr2:222434497 2 222434497 EPHA4 North shore -0.0353263 0.00825142 0.00001870319 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T ARIES None 2020-08-20 Saturated fatty acids EFO_0005110 None None DNA methylation Saturated fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 669 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.151 0.035 0.000019 None Battram-T_saturated_fatty_acids Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.00476 0.00111 0.000019 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 SPR protein levels (SeqId = 9287-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPR protein levels (SeqId = 9287-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sepiapterin reductase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_spr_protein_levels__seqid___9287-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CANX protein levels (SeqId = 8834-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CANX protein levels (SeqId = 8834-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calnexin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.486 0.114 0.000019 None Gadd-DA_canx_protein_levels__seqid___8834-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMEM230 protein levels (SeqId = 11542-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM230 protein levels (SeqId = 11542-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein 230 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_tmem230_protein_levels__seqid___11542-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TSNARE1 protein levels (SeqId = 7069-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TSNARE1 protein levels (SeqId = 7069-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: t-SNARE domain-containing protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_tsnare1_protein_levels__seqid___7069-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FHL1 protein levels (SeqId = 16814-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FHL1 protein levels (SeqId = 16814-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Four and a half LIM domains protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.113 0.000019 None Gadd-DA_fhl1_protein_levels__seqid___16814-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PVRL2 protein levels (SeqId = 6245-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PVRL2 protein levels (SeqId = 6245-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nectin-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_pvrl2_protein_levels__seqid___6245-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCAR protein levels (SeqId = 4987-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCAR protein levels (SeqId = 4987-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Immunoglobulin alpha Fc receptor 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_fcar_protein_levels__seqid___4987-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FARS2 protein levels (SeqId = 13941-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FARS2 protein levels (SeqId = 13941-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phenylalanine--tRNA ligase, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.000019 None Gadd-DA_fars2_protein_levels__seqid___13941-82__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0362266 0.00847824 0.00001941705 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.056052 0.0131263 0.00001965111 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0352316 0.00825145 0.00001969257 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Battram T ARIES None 2020-08-20 Polyunsaturated fatty acids EFO_0005110 None None DNA methylation Polyunsaturated fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 673 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.167 0.039 0.00002 None Battram-T_polyunsaturated_fatty_acids Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14652038 chr2:222343519 2 222343519 EPHA4 Open sea 0.00092 0.00022 0.00002 None 33450751_Mulder-RH_age_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 HSPA6 protein levels (SeqId = 13672-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPA6 protein levels (SeqId = 13672-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock 70 kDa protein 6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.00002 None Gadd-DA_hspa6_protein_levels__seqid___13672-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SIGLEC11 protein levels (SeqId = 8913-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIGLEC11 protein levels (SeqId = 8913-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialic acid-binding Ig-like lectin 11 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.00002 None Gadd-DA_siglec11_protein_levels__seqid___8913-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KLK9 protein levels (SeqId = 5758-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLK9 protein levels (SeqId = 5758-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kallikrein-9 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.00002 None Gadd-DA_klk9_protein_levels__seqid___5758-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KCNG4 protein levels (SeqId = 13525-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KCNG4 protein levels (SeqId = 13525-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Potassium voltage-gated channel subfamily G member 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.49 0.114 0.00002 None Gadd-DA_kcng4_protein_levels__seqid___13525-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C4orf32 protein levels (SeqId = 9490-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C4orf32 protein levels (SeqId = 9490-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein FAM241A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.00002 None Gadd-DA_c4orf32_protein_levels__seqid___9490-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HMGA1 protein levels (SeqId = 16536-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMGA1 protein levels (SeqId = 16536-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: High mobility group protein HMG-I/HMG-Y 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.00002 None Gadd-DA_hmga1_protein_levels__seqid___16536-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS15 protein levels (SeqId = 3189-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS15 protein levels (SeqId = 3189-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Enteropeptidase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.11 0.00002 None Gadd-DA_tmprss15_protein_levels__seqid___3189-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCNA1 protein levels (SeqId = 15319-226) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCNA1 protein levels (SeqId = 15319-226) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-A1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.00002 None Gadd-DA_ccna1_protein_levels__seqid___15319-226__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.862564 0.2023 0.0000201 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0351567 0.00825147 0.00002050924 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.041075 0.00964281 0.00002060283 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.187432 0.0440107 0.00002066414 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island 0.0351301 0.00825148 0.00002080729 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.00028 0.000065 0.000021 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 HS3ST4 protein levels (SeqId = 8998-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HS3ST4 protein levels (SeqId = 8998-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000021 None Gadd-DA_hs3st4_protein_levels__seqid___8998-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TGM4 protein levels (SeqId = 18933-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TGM4 protein levels (SeqId = 18933-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein-glutamine gamma-glutamyltransferase 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000021 None Gadd-DA_tgm4_protein_levels__seqid___18933-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYNN protein levels (SeqId = 12455-48) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYNN protein levels (SeqId = 12455-48) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myoneurin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000021 None Gadd-DA_mynn_protein_levels__seqid___12455-48__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZPBP protein levels (SeqId = 8635-283) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZPBP protein levels (SeqId = 8635-283) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zona pellucida-binding protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000021 None Gadd-DA_zpbp_protein_levels__seqid___8635-283__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSMA1 protein levels (SeqId = 7880-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMA1 protein levels (SeqId = 7880-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome subunit alpha type-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000021 None Gadd-DA_psma1_protein_levels__seqid___7880-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23317907 chr2:222437071 2 222437071 EPHA4 Island -0.0350996 0.00825148 0.00002115369 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.138573 0.0325868 0.00002125223 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0483129 0.0113647 0.00002139919 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0557361 0.013116 0.00002155989 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 SUSD3 protein levels (SeqId = 5752-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUSD3 protein levels (SeqId = 5752-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sushi domain-containing protein 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.113 0.000022 None Gadd-DA_susd3_protein_levels__seqid___5752-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DEFB110 protein levels (SeqId = 8340-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB110 protein levels (SeqId = 8340-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 110 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000022 None Gadd-DA_defb110_protein_levels__seqid___8340-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRPF6 protein levels (SeqId = 9581-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRPF6 protein levels (SeqId = 9581-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pre-mRNA-processing factor 6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000022 None Gadd-DA_prpf6_protein_levels__seqid___9581-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MACROD1 protein levels (SeqId = 13653-335) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MACROD1 protein levels (SeqId = 13653-335) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribose glycohydrolase MACROD1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000022 None Gadd-DA_macrod1_protein_levels__seqid___13653-335__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MCM6 protein levels (SeqId = 9897-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MCM6 protein levels (SeqId = 9897-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA replication licensing factor MCM6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000022 None Gadd-DA_mcm6_protein_levels__seqid___9897-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0349992 0.00825151 0.00002233481 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0378224 0.00891788 0.00002236984 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0349921 0.00825152 0.00002241978 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 KIF16B protein levels (SeqId = 11672-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIF16B protein levels (SeqId = 11672-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kinesin-like protein KIF16B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000023 None Gadd-DA_kif16b_protein_levels__seqid___11672-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD4 protein levels (SeqId = 3143-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD4 protein levels (SeqId = 3143-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-cell surface glycoprotein CD4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.113 0.000023 None Gadd-DA_cd4_protein_levels__seqid___3143-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LRFN1 protein levels (SeqId = 7910-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRFN1 protein levels (SeqId = 7910-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat and fibronectin type III domain-containing protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000023 None Gadd-DA_lrfn1_protein_levels__seqid___7910-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SFRP2 protein levels (SeqId = 7751-121) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SFRP2 protein levels (SeqId = 7751-121) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Secreted frizzled-related protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000023 None Gadd-DA_sfrp2_protein_levels__seqid___7751-121__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0376276 0.00889198 0.00002334117 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0490096 0.0115926 0.00002375723 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0492514 0.0116529 0.00002387447 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0394285 0.00932952 0.0000239095 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 RBM19 protein levels (SeqId = 11468-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBM19 protein levels (SeqId = 11468-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable RNA-binding protein 19 774 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.488 0.115 0.000024 None Gadd-DA_rbm19_protein_levels__seqid___11468-15__somascan_protein_measurement Hoang Agricultural Lung Health Study 34516295 Sep 13, 2021 ddt EFO_0007886 discovery 10.5281/zenodo.5156585 DNA methylation ddt Age, Smoking, Cell composition (reference based), residence,asthma Beta values None Illumina HumanMethylationEPIC whole blood None 1140 1 Adults Males European cg09980780 chr2:222294689 2 222294689 EPHA4 Open sea -0.00174 0.00041 0.000024 None 34516295_Hoang_ddt_discovery Gadd DA Generation Scotland 35945220 31/07/2022 CHST11 protein levels (SeqId = 7779-86) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHST11 protein levels (SeqId = 7779-86) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carbohydrate sulfotransferase 11 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000024 None Gadd-DA_chst11_protein_levels__seqid___7779-86__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FBL protein levels (SeqId = 13994-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FBL protein levels (SeqId = 13994-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: rRNA 2'-O-methyltransferase fibrillarin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000024 None Gadd-DA_fbl_protein_levels__seqid___13994-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SULT2B1 protein levels (SeqId = 17209-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SULT2B1 protein levels (SeqId = 17209-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sulfotransferase family cytosolic 2B member 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.113 0.000024 None Gadd-DA_sult2b1_protein_levels__seqid___17209-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PXDNL protein levels (SeqId = 11324-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PXDNL protein levels (SeqId = 11324-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxidasin-like protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000024 None Gadd-DA_pxdnl_protein_levels__seqid___11324-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGFR3 protein levels (SeqId = 3809-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGFR3 protein levels (SeqId = 3809-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor receptor 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000024 None Gadd-DA_fgfr3_protein_levels__seqid___3809-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0348636 0.00825155 0.00002402767 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0376742 0.00892967 0.00002468702 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.203648 0.0482911 0.00002487226 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 LDOC1 protein levels (SeqId = 8378-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LDOC1 protein levels (SeqId = 8378-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein LDOC1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000025 None Gadd-DA_ldoc1_protein_levels__seqid___8378-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0364672 0.00865678 0.00002540034 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.035694 0.00848306 0.00002595397 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3 Battram T GEO 23792949 2020-09-15 Ethnicity EFO_0001799 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE39672. Compared European and African samples from HapMap (CEU and YRI) None DNA methylation Ethnicity Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Lymphoblasts None 133 1 Adults Both European, African cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.171 0.0389 0.000026 None 23792949_Battram-T_ethnicity_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse39672__compared_european_and_african_samples_from_hapmap__ceu_and_yri_ Gadd DA Generation Scotland 35945220 31/07/2022 ZWILCH protein levels (SeqId = 18302-204) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZWILCH protein levels (SeqId = 18302-204) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein zwilch homolog 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000026 None Gadd-DA_zwilch_protein_levels__seqid___18302-204__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCRL3 protein levels (SeqId = 4440-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCRL3 protein levels (SeqId = 4440-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fc receptor-like protein 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000026 None Gadd-DA_fcrl3_protein_levels__seqid___4440-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MGAT4A protein levels (SeqId = 9392-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MGAT4A protein levels (SeqId = 9392-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000026 None Gadd-DA_mgat4a_protein_levels__seqid___9392-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NGRN protein levels (SeqId = 7153-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NGRN protein levels (SeqId = 7153-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neugrin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000026 None Gadd-DA_ngrn_protein_levels__seqid___7153-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0347166 0.00825159 0.00002600261 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25272554 chr2:222437075 2 222437075 EPHA4 Island -0.00088 0.00021 0.000027 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 FAM171B protein levels (SeqId = 8786-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM171B protein levels (SeqId = 8786-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein FAM171B 774 1 Adults (18-65 years) Both European cg24139506 chr2:222298497 2 222298497 EPHA4 Open sea 0.34 0.081 0.000027 None Gadd-DA_fam171b_protein_levels__seqid___8786-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EPHA10 protein levels (SeqId = 5076-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EPHA10 protein levels (SeqId = 5076-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ephrin type-A receptor 10 774 1 Adults (18-65 years) Both European cg24139506 chr2:222298497 2 222298497 EPHA4 Open sea 0.34 0.081 0.000027 None Gadd-DA_epha10_protein_levels__seqid___5076-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDH11 protein levels (SeqId = 7763-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDH11 protein levels (SeqId = 7763-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cadherin-11 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000027 None Gadd-DA_cdh11_protein_levels__seqid___7763-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ST6GALNAC2 protein levels (SeqId = 7823-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST6GALNAC2 protein levels (SeqId = 7823-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000027 None Gadd-DA_st6galnac2_protein_levels__seqid___7823-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DDX25 protein levels (SeqId = 13984-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DDX25 protein levels (SeqId = 13984-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATP-dependent RNA helicase DDX25 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.477 0.114 0.000027 None Gadd-DA_ddx25_protein_levels__seqid___13984-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EMID1 protein levels (SeqId = 9547-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EMID1 protein levels (SeqId = 9547-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: EMI domain-containing protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.11 0.000027 None Gadd-DA_emid1_protein_levels__seqid___9547-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0346246 0.00825162 0.00002731589 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg19831186 chr2:222312142 2 222312142 EPHA4 Open sea 0.131224 0.0312961 0.00002766151 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ASTL protein levels (SeqId = 7993-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASTL protein levels (SeqId = 7993-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Astacin-like metalloendopeptidase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000028 None Gadd-DA_astl_protein_levels__seqid___7993-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZNF415 protein levels (SeqId = 12811-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF415 protein levels (SeqId = 12811-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 415 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.11 0.000028 None Gadd-DA_znf415_protein_levels__seqid___12811-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B4GALT3 protein levels (SeqId = 6921-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B4GALT3 protein levels (SeqId = 6921-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,4-galactosyltransferase 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000028 None Gadd-DA_b4galt3_protein_levels__seqid___6921-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.0355207 0.00848046 0.00002823958 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0372568 0.00890045 0.00002856397 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0547377 0.0130792 0.00002867252 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0391342 0.00935356 0.00002882391 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PI15 protein levels (SeqId = 5745-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PI15 protein levels (SeqId = 5745-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidase inhibitor 15 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.48 0.114 0.000029 None Gadd-DA_pi15_protein_levels__seqid___5745-64__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0355011 0.00849537 0.00002946575 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0344713 0.00825166 0.00002964369 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CELA3B protein levels (SeqId = 6357-83) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CELA3B protein levels (SeqId = 6357-83) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chymotrypsin-like elastase family member 3B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00003 None Gadd-DA_cela3b_protein_levels__seqid___6357-83__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LTA protein levels (SeqId = 4703-87) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LTA protein levels (SeqId = 4703-87) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lymphotoxin-alpha 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00003 None Gadd-DA_lta_protein_levels__seqid___4703-87__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACPL2 protein levels (SeqId = 6079-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACPL2 protein levels (SeqId = 6079-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 2-phosphoxylose phosphatase 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00003 None Gadd-DA_acpl2_protein_levels__seqid___6079-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ERLIN1 protein levels (SeqId = 8776-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERLIN1 protein levels (SeqId = 8776-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Erlin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00003 None Gadd-DA_erlin1_protein_levels__seqid___8776-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.0355278 0.00852379 0.00003089483 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 C2orf40 protein levels (SeqId = 6362-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C2orf40 protein levels (SeqId = 6362-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Augurin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000031 None Gadd-DA_c2orf40_protein_levels__seqid___6362-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CEBPA protein levels (SeqId = 18874-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CEBPA protein levels (SeqId = 18874-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CCAAT/enhancer-binding protein alpha 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.113 0.000031 None Gadd-DA_cebpa_protein_levels__seqid___18874-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCCIP protein levels (SeqId = 18304-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCCIP protein levels (SeqId = 18304-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BRCA2 and CDKN1A-interacting protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.474 0.114 0.000031 None Gadd-DA_bccip_protein_levels__seqid___18304-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RSPO1 protein levels (SeqId = 6240-70) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RSPO1 protein levels (SeqId = 6240-70) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: R-spondin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.474 0.114 0.000031 None Gadd-DA_rspo1_protein_levels__seqid___6240-70__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPNMB protein levels (SeqId = 8606-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPNMB protein levels (SeqId = 8606-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane glycoprotein NMB 774 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 1.16 0.279 0.000031 None Gadd-DA_gpnmb_protein_levels__seqid___8606-39__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island -0.0353432 0.00848533 0.00003128422 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.034362 0.0082517 0.00003141792 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0547799 0.0131581 0.00003155818 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.89 0.214 0.000032 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPR135 protein levels (SeqId = 11465-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPR135 protein levels (SeqId = 11465-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: G-protein coupled receptor 135 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000032 None Gadd-DA_gpr135_protein_levels__seqid___11465-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0483959 0.0116439 0.00003252414 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0482737 0.0116151 0.00003255457 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0342792 0.00825172 0.00003283006 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 COX4I2 protein levels (SeqId = 7850-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COX4I2 protein levels (SeqId = 7850-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000033 None Gadd-DA_cox4i2_protein_levels__seqid___7850-1__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea -0.031 0.00749 0.000035 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 IL36B protein levels (SeqId = 14149-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL36B protein levels (SeqId = 14149-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-36 beta 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000035 None Gadd-DA_il36b_protein_levels__seqid___14149-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23611672 chr2:222367424 2 222367424 EPHA4 Open sea -0.0341455 0.00825176 0.00003523507 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08965464 chr2:222436985 2 222436985 EPHA4 Island -0.035032 0.00846875 0.00003544274 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0368075 0.00890066 0.00003563612 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0341219 0.00825176 0.0000356765 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HBD protein levels (SeqId = 6992-67) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HBD protein levels (SeqId = 6992-67) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hemoglobin subunit delta 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000036 None Gadd-DA_hbd_protein_levels__seqid___6992-67__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD58 protein levels (SeqId = 10938-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD58 protein levels (SeqId = 10938-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lymphocyte function-associated antigen 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000036 None Gadd-DA_cd58_protein_levels__seqid___10938-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 P2RX6 protein levels (SeqId = 7233-73) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 P2RX6 protein levels (SeqId = 7233-73) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: P2X purinoceptor 6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000037 None Gadd-DA_p2rx6_protein_levels__seqid___7233-73__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.0340425 0.00825179 0.00003720139 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0340414 0.00825179 0.00003722309 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01446950 chr2:222435351 2 222435351 EPHA4 North shore 0.0342542 0.00831197 0.00003791848 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg09980780 chr2:222294689 2 222294689 EPHA4 Open sea 0.029 0.00712 0.000038 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 CLEC4D protein levels (SeqId = 7752-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLEC4D protein levels (SeqId = 7752-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-type lectin domain family 4 member D 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000038 None Gadd-DA_clec4d_protein_levels__seqid___7752-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0339853 0.0082518 0.00003833901 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0366028 0.00889086 0.00003861037 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Battram T ARIES None 2020-08-20 Cholesterol esters in medium LDL EFO_0008589 None None DNA methylation Cholesterol esters in medium LDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.83 0.2 0.000039 None Battram-T_cholesterol_esters_in_medium_ldl Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg08787401 chr2:222383520 2 222383520 EPHA4 Open sea 0.145561 0.0354118 0.00003964676 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0527544 0.0128395 0.00003999681 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 DNAI1 protein levels (SeqId = 11396-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAI1 protein levels (SeqId = 11396-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dynein intermediate chain 1, axonemal 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00004 None Gadd-DA_dnai1_protein_levels__seqid___11396-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PFKFB3 protein levels (SeqId = 12456-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PFKFB3 protein levels (SeqId = 12456-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00004 None Gadd-DA_pfkfb3_protein_levels__seqid___12456-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2A protein levels (SeqId = 17743-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2A protein levels (SeqId = 17743-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00004 None Gadd-DA_ube2a_protein_levels__seqid___17743-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SCARA3 protein levels (SeqId = 11292-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCARA3 protein levels (SeqId = 11292-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Scavenger receptor class A member 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.00004 None Gadd-DA_scara3_protein_levels__seqid___11292-13__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25272554 chr2:222437075 2 222437075 EPHA4 Island 0.00013 None 0.000041 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 APOL3 protein levels (SeqId = 16823-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOL3 protein levels (SeqId = 16823-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein L3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000041 None Gadd-DA_apol3_protein_levels__seqid___16823-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITM2A protein levels (SeqId = 7765-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITM2A protein levels (SeqId = 7765-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integral membrane protein 2A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000041 None Gadd-DA_itm2a_protein_levels__seqid___7765-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZP4 protein levels (SeqId = 7766-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZP4 protein levels (SeqId = 7766-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zona pellucida sperm-binding protein 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000041 None Gadd-DA_zp4_protein_levels__seqid___7766-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHI3L2 protein levels (SeqId = 9383-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHI3L2 protein levels (SeqId = 9383-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chitinase-3-like protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.114 0.000041 None Gadd-DA_chi3l2_protein_levels__seqid___9383-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COLEC10 protein levels (SeqId = 6558-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COLEC10 protein levels (SeqId = 6558-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collectin-10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.47 0.113 0.000041 None Gadd-DA_colec10_protein_levels__seqid___6558-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.0403632 0.00983763 0.00004101418 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10871883 chr2:222290943 2 222290943 EPHA4 Open sea 0.0338561 0.00825184 0.00004102782 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0338548 0.00825184 0.00004105741 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0366896 0.00894536 0.00004126592 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3 Battram T ARIES None 2020-08-20 Concentration of very small VLDL particles EFO_0008317 None None DNA methylation Concentration of very small VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -13000000 None 0.000042 None Battram-T_concentration_of_very_small_vldl_particles Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25272554 chr2:222437075 2 222437075 EPHA4 Island 0.0337839 0.00825186 0.00004260919 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.0069 0.0017 0.000043 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 CD72 protein levels (SeqId = 7009-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD72 protein levels (SeqId = 7009-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: B-cell differentiation antigen CD72 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000043 None Gadd-DA_cd72_protein_levels__seqid___7009-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RABEPK protein levels (SeqId = 13599-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RABEPK protein levels (SeqId = 13599-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rab9 effector protein with kelch motifs 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000043 None Gadd-DA_rabepk_protein_levels__seqid___13599-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0342557 0.00837963 0.00004374715 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SCN2B protein levels (SeqId = 8353-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCN2B protein levels (SeqId = 8353-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sodium channel subunit beta-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.113 0.000044 None Gadd-DA_scn2b_protein_levels__seqid___8353-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCNA2 protein levels (SeqId = 15574-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCNA2 protein levels (SeqId = 15574-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-A2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000044 None Gadd-DA_ccna2_protein_levels__seqid___15574-37__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0467637 0.0114472 0.0000442829 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.029 0.00703 0.000045 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 CTSC protein levels (SeqId = 3178-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTSC protein levels (SeqId = 3178-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dipeptidyl peptidase 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000045 None Gadd-DA_ctsc_protein_levels__seqid___3178-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSPA1L protein levels (SeqId = 12041-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPA1L protein levels (SeqId = 12041-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock 70 kDa protein 1-like 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000045 None Gadd-DA_hspa1l_protein_levels__seqid___12041-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0473393 0.0116046 0.0000454008 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA2 protein levels (SeqId = 5756-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA2 protein levels (SeqId = 5756-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000046 None Gadd-DA_pappa2_protein_levels__seqid___5756-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITGB5 protein levels (SeqId = 7755-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITGB5 protein levels (SeqId = 7755-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integrin beta-5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000046 None Gadd-DA_itgb5_protein_levels__seqid___7755-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITGA5 protein levels (SeqId = 6932-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITGA5 protein levels (SeqId = 6932-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integrin alpha-5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000046 None Gadd-DA_itga5_protein_levels__seqid___6932-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.03631 0.00891386 0.0000465692 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0336018 0.00825191 0.00004685553 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.005 0.0012 0.000047 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 DSC1 protein levels (SeqId = 10882-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DSC1 protein levels (SeqId = 10882-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Desmocollin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000047 None Gadd-DA_dsc1_protein_levels__seqid___10882-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHST14 protein levels (SeqId = 7262-191) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHST14 protein levels (SeqId = 7262-191) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carbohydrate sulfotransferase 14 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000047 None Gadd-DA_chst14_protein_levels__seqid___7262-191__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02754631 chr2:222290791 2 222290791 EPHA4 Open sea 0.0335829 0.00825191 0.00004731912 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0335633 0.00825192 0.00004780209 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0048 0.0012 0.000048 - 27651444_smoking_current_vs_never_smoking Gadd DA Generation Scotland 35945220 31/07/2022 B3GNT6 protein levels (SeqId = 7082-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B3GNT6 protein levels (SeqId = 7082-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.11 0.000048 None Gadd-DA_b3gnt6_protein_levels__seqid___7082-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC15 protein levels (SeqId = 7197-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC15 protein levels (SeqId = 7197-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 15 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000048 None Gadd-DA_dnajc15_protein_levels__seqid___7197-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF148 protein levels (SeqId = 7742-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF148 protein levels (SeqId = 7742-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RING finger protein 148 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000048 None Gadd-DA_rnf148_protein_levels__seqid___7742-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HEPACAM2 protein levels (SeqId = 9116-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HEPACAM2 protein levels (SeqId = 9116-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: HEPACAM family member 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000048 None Gadd-DA_hepacam2_protein_levels__seqid___9116-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03258293 chr2:222384727 2 222384727 EPHA4 Open sea 0.0402377 0.00989822 0.0000482539 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg16786808 chr2:222434497 2 222434497 EPHA4 North shore 0.01 0.0024 0.000049 None 33564054_Kashima-K_gestational_age Gadd DA Generation Scotland 35945220 31/07/2022 NRSN1 protein levels (SeqId = 11654-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NRSN1 protein levels (SeqId = 11654-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neurensin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000049 None Gadd-DA_nrsn1_protein_levels__seqid___11654-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCPG1 protein levels (SeqId = 8889-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCPG1 protein levels (SeqId = 8889-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cell cycle progression protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000049 None Gadd-DA_ccpg1_protein_levels__seqid___8889-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSG6 protein levels (SeqId = 6456-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSG6 protein levels (SeqId = 6456-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pregnancy-specific beta-1-glycoprotein 6 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000049 None Gadd-DA_psg6_protein_levels__seqid___6456-17__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.981671 0.2419 0.0000494 - 27105112_hiv_infection_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ZHX1 protein levels (SeqId = 12751-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZHX1 protein levels (SeqId = 12751-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc fingers and homeoboxes protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.00005 None Gadd-DA_zhx1_protein_levels__seqid___12751-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIAA1324L protein levels (SeqId = 8363-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA1324L protein levels (SeqId = 8363-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UPF0577 protein KIAA1324-like 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.00005 None Gadd-DA_kiaa1324l_protein_levels__seqid___8363-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB17 protein levels (SeqId = 11118-107) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB17 protein levels (SeqId = 11118-107) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-17 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000051 None Gadd-DA_rab17_protein_levels__seqid___11118-107__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRAS protein levels (SeqId = 18297-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRAS protein levels (SeqId = 18297-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein M-Ras 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000051 None Gadd-DA_mras_protein_levels__seqid___18297-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0468655 0.0115723 0.00005152387 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg16786808 chr2:222434497 2 222434497 EPHA4 North shore 0.0159 0.0039 0.000052 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg16786808 chr2:222434497 2 222434497 EPHA4 North shore 0.016 0.004 0.0000522 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Gadd DA Generation Scotland 35945220 31/07/2022 NISCH protein levels (SeqId = 12738-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NISCH protein levels (SeqId = 12738-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nischarin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000053 None Gadd-DA_nisch_protein_levels__seqid___12738-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BMPR2 protein levels (SeqId = 4862-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMPR2 protein levels (SeqId = 4862-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein receptor type-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000053 None Gadd-DA_bmpr2_protein_levels__seqid___4862-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPH1 protein levels (SeqId = 14309-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPH1 protein levels (SeqId = 14309-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein H 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000053 None Gadd-DA_hnrnph1_protein_levels__seqid___14309-8__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea -0.0095 0.0024 0.000054 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 CAMP protein levels (SeqId = 9384-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CAMP protein levels (SeqId = 9384-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cathelicidin antimicrobial peptide 774 1 Adults (18-65 years) Both European cg07916307 chr2:222288068 2 222288068 EPHA4 Open sea 0.55 0.135 0.000054 None Gadd-DA_camp_protein_levels__seqid___9384-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GORAB protein levels (SeqId = 7247-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GORAB protein levels (SeqId = 7247-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RAB6-interacting golgin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000054 None Gadd-DA_gorab_protein_levels__seqid___7247-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LSM4 protein levels (SeqId = 16854-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LSM4 protein levels (SeqId = 16854-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: U6 snRNA-associated Sm-like protein LSm4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000054 None Gadd-DA_lsm4_protein_levels__seqid___16854-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PECAM1 protein levels (SeqId = 2695-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PECAM1 protein levels (SeqId = 2695-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet endothelial cell adhesion molecule 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000054 None Gadd-DA_pecam1_protein_levels__seqid___2695-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITPKA protein levels (SeqId = 13473-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITPKA protein levels (SeqId = 13473-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inositol-trisphosphate 3-kinase A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.11 0.000054 None Gadd-DA_itpka_protein_levels__seqid___13473-55__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0487097 0.0120612 0.0000540571 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.046108 0.0114212 0.00005439835 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0333028 0.00825199 0.0000547094 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Battram T ARIES None 2020-08-20 Total lipids in very small VLDL EFO_0004529 None None DNA methylation Total lipids in very small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.86 0.21 0.000055 None Battram-T_total_lipids_in_very_small_vldl Gadd DA Generation Scotland 35945220 31/07/2022 PTX3 protein levels (SeqId = 6447-73) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTX3 protein levels (SeqId = 6447-73) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pentraxin-related protein PTX3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000055 None Gadd-DA_ptx3_protein_levels__seqid___6447-73__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PCDHB2 protein levels (SeqId = 10748-216) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PCDHB2 protein levels (SeqId = 10748-216) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protocadherin beta-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000055 None Gadd-DA_pcdhb2_protein_levels__seqid___10748-216__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DEFB135 protein levels (SeqId = 6411-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB135 protein levels (SeqId = 6411-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 135 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000055 None Gadd-DA_defb135_protein_levels__seqid___6411-58__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0352611 0.00874236 0.00005526471 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea 0.0332732 0.008252 0.0000555499 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TXNIP protein levels (SeqId = 11682-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNIP protein levels (SeqId = 11682-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin-interacting protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000056 None Gadd-DA_txnip_protein_levels__seqid___11682-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 H2AFZ protein levels (SeqId = 4163-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 H2AFZ protein levels (SeqId = 4163-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone H2A.Z 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000056 None Gadd-DA_h2afz_protein_levels__seqid___4163-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NPPB protein levels (SeqId = 3723-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPPB protein levels (SeqId = 3723-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Natriuretic peptides B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.113 0.000056 None Gadd-DA_nppb_protein_levels__seqid___3723-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0506899 0.0125886 0.00005686129 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0332234 0.00825201 0.00005699546 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FLT1 protein levels (SeqId = 16315-105) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FLT1 protein levels (SeqId = 16315-105) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vascular endothelial growth factor receptor 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000057 None Gadd-DA_flt1_protein_levels__seqid___16315-105__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF43 protein levels (SeqId = 14120-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF43 protein levels (SeqId = 14120-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RNF43 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.457 0.114 0.000057 None Gadd-DA_rnf43_protein_levels__seqid___14120-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BAG3 protein levels (SeqId = 10078-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAG3 protein levels (SeqId = 10078-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BAG family molecular chaperone regulator 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000057 None Gadd-DA_bag3_protein_levels__seqid___10078-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0459915 0.0114242 0.00005707134 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0465968 0.0115803 0.00005755533 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06301161 chr2:222302347 2 222302347 EPHA4 Open sea -0.0332043 0.00825202 0.00005756044 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0375471 0.00933473 0.00005791978 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PMEPA1 protein levels (SeqId = 6936-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PMEPA1 protein levels (SeqId = 6936-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein TMEPAI 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000058 None Gadd-DA_pmepa1_protein_levels__seqid___6936-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TAC4 protein levels (SeqId = 6468-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TAC4 protein levels (SeqId = 6468-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tachykinin-4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000058 None Gadd-DA_tac4_protein_levels__seqid___6468-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TACSTD2 protein levels (SeqId = 14034-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TACSTD2 protein levels (SeqId = 14034-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor-associated calcium signal transducer 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000058 None Gadd-DA_tacstd2_protein_levels__seqid___14034-22__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19831186 chr2:222312142 2 222312142 EPHA4 Open sea 0.0331864 0.00825202 0.00005809266 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.0331858 0.00825202 0.0000581091 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg00692780 chr2:222434778 2 222434778 EPHA4 North shore 0.0067 0.0016 0.000059 None 33564054_Kashima-K_gestational_age Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg16786808 chr2:222434497 2 222434497 EPHA4 North shore 0.013 0.003 0.000059 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Gadd DA Generation Scotland 35945220 31/07/2022 PAXIP1 protein levels (SeqId = 12894-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAXIP1 protein levels (SeqId = 12894-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PAX-interacting protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000059 None Gadd-DA_paxip1_protein_levels__seqid___12894-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZBTB33 protein levels (SeqId = 12785-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZBTB33 protein levels (SeqId = 12785-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcriptional regulator Kaiso 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.456 0.114 0.00006 None Gadd-DA_zbtb33_protein_levels__seqid___12785-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DEFB107A protein levels (SeqId = 6399-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB107A protein levels (SeqId = 6399-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 107 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.00006 None Gadd-DA_defb107a_protein_levels__seqid___6399-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSF2RB protein levels (SeqId = 11137-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSF2RB protein levels (SeqId = 11137-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytokine receptor common subunit beta 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.00006 None Gadd-DA_csf2rb_protein_levels__seqid___11137-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPR protein levels (SeqId = 13512-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPR protein levels (SeqId = 13512-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein R 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.00006 None Gadd-DA_hnrnpr_protein_levels__seqid___13512-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13029853 chr2:222418040 2 222418040 EPHA4 Open sea -0.0330952 0.00825205 0.00006087894 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.033092 0.00825205 0.00006097926 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 USP28 protein levels (SeqId = 19562-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 USP28 protein levels (SeqId = 19562-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin carboxyl-terminal hydrolase 28 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.46 0.114 0.000061 None Gadd-DA_usp28_protein_levels__seqid___19562-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0330623 0.00825206 0.00006191539 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 C1GALT1C1 protein levels (SeqId = 5735-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C1GALT1C1 protein levels (SeqId = 5735-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C1GALT1-specific chaperone 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000062 None Gadd-DA_c1galt1c1_protein_levels__seqid___5735-54__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.035728 0.00892082 0.00006231983 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10871883 chr2:222290943 2 222290943 EPHA4 Open sea -0.160669 0.0401313 0.00006265084 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 GRAP2 protein levels (SeqId = 16074-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRAP2 protein levels (SeqId = 16074-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GRB2-related adapter protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000063 None Gadd-DA_grap2_protein_levels__seqid___16074-12__somascan_protein_measurement Battram T ARIES None 2020-08-20 Total cholesterol in small VLDL EFO_0004574 None None DNA methylation Total cholesterol in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -1.43 0.36 0.000064 None Battram-T_total_cholesterol_in_small_vldl Gadd DA Generation Scotland 35945220 31/07/2022 CD207 protein levels (SeqId = 3361-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD207 protein levels (SeqId = 3361-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-type lectin domain family 4 member K 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000064 None Gadd-DA_cd207_protein_levels__seqid___3361-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DKKL1 protein levels (SeqId = 16309-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DKKL1 protein levels (SeqId = 16309-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dickkopf-like protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000064 None Gadd-DA_dkkl1_protein_levels__seqid___16309-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNGT2 protein levels (SeqId = 10917-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNGT2 protein levels (SeqId = 10917-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000064 None Gadd-DA_gngt2_protein_levels__seqid___10917-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UTS2 protein levels (SeqId = 6020-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UTS2 protein levels (SeqId = 6020-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Urotensin-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.113 0.000064 None Gadd-DA_uts2_protein_levels__seqid___6020-52__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0392376 0.00981539 0.00006431176 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.035514 0.00888756 0.00006475834 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea -0.0329653 0.00825208 0.00006506805 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea 0.0439329 0.0110023 0.00006554122 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00692780 chr2:222434778 2 222434778 EPHA4 North shore -0.0329481 0.00825209 0.00006564443 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 POTEG protein levels (SeqId = 7960-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POTEG protein levels (SeqId = 7960-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: POTE ankyrin domain family member G 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000066 None Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement Battram T ARIES None 2020-08-20 Phospholipids in medium LDL EFO_0004639 None None DNA methylation Phospholipids in medium LDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -2.6 0.64 0.000067 None Battram-T_phospholipids_in_medium_ldl Gadd DA Generation Scotland 35945220 31/07/2022 RELT protein levels (SeqId = 14112-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RELT protein levels (SeqId = 14112-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor receptor superfamily member 19L 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.113 0.000067 None Gadd-DA_relt_protein_levels__seqid___14112-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CUL9 protein levels (SeqId = 12991-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CUL9 protein levels (SeqId = 12991-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cullin-9 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000067 None Gadd-DA_cul9_protein_levels__seqid___12991-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TCP11 protein levels (SeqId = 8334-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TCP11 protein levels (SeqId = 8334-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-complex protein 11 homolog 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000067 None Gadd-DA_tcp11_protein_levels__seqid___8334-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPIG protein levels (SeqId = 18449-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIG protein levels (SeqId = 18449-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase G 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000067 None Gadd-DA_ppig_protein_levels__seqid___18449-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2C protein levels (SeqId = 12556-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2C protein levels (SeqId = 12556-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 C 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000067 None Gadd-DA_ube2c_protein_levels__seqid___12556-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23317907 chr2:222437071 2 222437071 EPHA4 Island -0.0327804 0.00822058 0.00006706738 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0386839 0.00970724 0.00006779208 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Battram T ARIES None 2020-08-20 Phospholipids in very small VLDL EFO_0004639 None None DNA methylation Phospholipids in very small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -2.6 0.66 0.000068 None Battram-T_phospholipids_in_very_small_vldl Battram T ARIES None 2020-08-20 Total cholesterol in VLDL EFO_0004574 None None DNA methylation Total cholesterol in VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 681 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.46 0.115 0.000068 None Battram-T_total_cholesterol_in_vldl Gadd DA Generation Scotland 35945220 31/07/2022 IGFLR1 protein levels (SeqId = 7244-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGFLR1 protein levels (SeqId = 7244-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: IGF-like family receptor 1 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.85 0.214 0.000068 None Gadd-DA_igflr1_protein_levels__seqid___7244-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 QRFP protein levels (SeqId = 6463-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QRFP protein levels (SeqId = 6463-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Orexigenic neuropeptide QRFP 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000068 None Gadd-DA_qrfp_protein_levels__seqid___6463-59__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19831186 chr2:222312142 2 222312142 EPHA4 Open sea 0.0328915 0.00826168 0.00006889628 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Battram T ARIES None 2020-08-20 LDL cholesterol EFO_0004195 fasting None DNA methylation LDL cholesterol Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 692 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.134 0.034 0.000069 None Battram-T_ldl_cholesterol_fasting Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.0027 None 0.000069 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 CRIPT protein levels (SeqId = 19294-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRIPT protein levels (SeqId = 19294-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cysteine-rich PDZ-binding protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000069 None Gadd-DA_cript_protein_levels__seqid___19294-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SIGLEC15 protein levels (SeqId = 10847-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIGLEC15 protein levels (SeqId = 10847-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialic acid-binding Ig-like lectin 15 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000069 None Gadd-DA_siglec15_protein_levels__seqid___10847-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF3 protein levels (SeqId = 7894-155) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF3 protein levels (SeqId = 7894-155) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000069 None Gadd-DA_fgf3_protein_levels__seqid___7894-155__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ENTPD1 protein levels (SeqId = 3182-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ENTPD1 protein levels (SeqId = 3182-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000069 None Gadd-DA_entpd1_protein_levels__seqid___3182-38__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea 0.0328337 0.00825212 0.00006959135 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0384333 0.00966077 0.00006974748 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea -0.032826 0.00825212 0.0000698663 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 NPM1 protein levels (SeqId = 8870-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPM1 protein levels (SeqId = 8870-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nucleophosmin 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.11 0.00007 None Gadd-DA_npm1_protein_levels__seqid___8870-38__somascan_protein_measurement Battram T ARIES None 2020-08-20 Cholesterol esters in small LDL EFO_0008589 None None DNA methylation Cholesterol esters in small LDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -1.3 0.33 0.000071 None Battram-T_cholesterol_esters_in_small_ldl Gadd DA Generation Scotland 35945220 31/07/2022 SERPINI2 protein levels (SeqId = 7117-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPINI2 protein levels (SeqId = 7117-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serpin I2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000071 None Gadd-DA_serpini2_protein_levels__seqid___7117-21__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0075 0.0019 0.000072 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 CD38 protein levels (SeqId = 11513-92) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD38 protein levels (SeqId = 11513-92) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.451 0.114 0.000072 None Gadd-DA_cd38_protein_levels__seqid___11513-92__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KCNE5 protein levels (SeqId = 8756-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KCNE5 protein levels (SeqId = 8756-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Potassium voltage-gated channel subfamily E regulatory beta subunit 5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000072 None Gadd-DA_kcne5_protein_levels__seqid___8756-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 JPH4 protein levels (SeqId = 9111-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 JPH4 protein levels (SeqId = 9111-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Junctophilin-4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000072 None Gadd-DA_jph4_protein_levels__seqid___9111-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0327429 0.00825214 0.0000728829 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0327221 0.00825215 0.00007365546 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TMEM38B protein levels (SeqId = 9509-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM38B protein levels (SeqId = 9509-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trimeric intracellular cation channel type B 774 1 Adults (18-65 years) Both European cg18527574 chr2:222434303 2 222434303 EPHA4 North shore 0.32 0.081 0.000074 None Gadd-DA_tmem38b_protein_levels__seqid___9509-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CALN1 protein levels (SeqId = 10933-107) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CALN1 protein levels (SeqId = 10933-107) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcium-binding protein 8 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_caln1_protein_levels__seqid___10933-107__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STX1B protein levels (SeqId = 6966-144) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STX1B protein levels (SeqId = 6966-144) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Syntaxin-1B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_stx1b_protein_levels__seqid___6966-144__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LCN1 protein levels (SeqId = 11708-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LCN1 protein levels (SeqId = 11708-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lipocalin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.451 0.114 0.000074 None Gadd-DA_lcn1_protein_levels__seqid___11708-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PARP1 protein levels (SeqId = 10534-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PARP1 protein levels (SeqId = 10534-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Poly [ADP-ribose] polymerase 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_parp1_protein_levels__seqid___10534-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B4GALT5 protein levels (SeqId = 10425-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B4GALT5 protein levels (SeqId = 10425-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,4-galactosyltransferase 5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.113 0.000074 None Gadd-DA_b4galt5_protein_levels__seqid___10425-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACVR2A protein levels (SeqId = 19208-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACVR2A protein levels (SeqId = 19208-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activin receptor type-2A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_acvr2a_protein_levels__seqid___19208-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTPN9 protein levels (SeqId = 12633-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTPN9 protein levels (SeqId = 12633-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tyrosine-protein phosphatase non-receptor type 9 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_ptpn9_protein_levels__seqid___12633-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BMP8B protein levels (SeqId = 15668-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMP8B protein levels (SeqId = 15668-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein 8B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_bmp8b_protein_levels__seqid___15668-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF24 protein levels (SeqId = 9583-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF24 protein levels (SeqId = 9583-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RING finger protein 24 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000074 None Gadd-DA_rnf24_protein_levels__seqid___9583-17__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08787401 chr2:222383520 2 222383520 EPHA4 Open sea -0.0002 0.000051 0.000075 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 GOSR1 protein levels (SeqId = 7805-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GOSR1 protein levels (SeqId = 7805-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Golgi SNAP receptor complex member 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000075 None Gadd-DA_gosr1_protein_levels__seqid___7805-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD70 protein levels (SeqId = 5807-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD70 protein levels (SeqId = 5807-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CD70 antigen 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000075 None Gadd-DA_cd70_protein_levels__seqid___5807-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNFSF13B protein levels (SeqId = 3059-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFSF13B protein levels (SeqId = 3059-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor ligand superfamily member 13B 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000075 None Gadd-DA_tnfsf13b_protein_levels__seqid___3059-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea 0.0326714 0.00825216 0.00007557708 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Xu C-J MAKI 34473906 2021-09-02 RSV immunoprophylaxis in infancy None None None DNA methylation RSV immunoprophylaxis in infancy Age, Sex, Smoking, Surrogate variables M values None Illumina HumanMethylationEPIC nasal epithelium None 274 1 Children Both European cg24139506 chr2:222298497 2 222298497 EPHA4 Open sea -0.233 0.059 0.000076 None 34473906_Xu-C-J_rsv_immunoprophylaxis_in_infancy Gadd DA Generation Scotland 35945220 31/07/2022 CNTNAP5 protein levels (SeqId = 9044-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNTNAP5 protein levels (SeqId = 9044-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Contactin-associated protein-like 5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000076 None Gadd-DA_cntnap5_protein_levels__seqid___9044-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRAMD1C protein levels (SeqId = 8336-267) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRAMD1C protein levels (SeqId = 8336-267) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein Aster-C 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000076 None Gadd-DA_gramd1c_protein_levels__seqid___8336-267__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0326353 0.00825217 0.00007697214 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 RAG1 protein levels (SeqId = 11311-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAG1 protein levels (SeqId = 11311-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: V(D)J recombination-activating protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000077 None Gadd-DA_rag1_protein_levels__seqid___11311-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VPS28 protein levels (SeqId = 17155-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VPS28 protein levels (SeqId = 17155-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vacuolar protein sorting-associated protein 28 homolog 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000077 None Gadd-DA_vps28_protein_levels__seqid___17155-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0457683 0.011574 0.00007708554 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13364311 chr2:222333289 2 222333289 EPHA4 Open sea 0.0326648 0.00826314 0.00007751571 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0326139 0.00825218 0.00007781374 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.0912715 0.0230959 0.00007784069 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Battram T ARIES None 2020-08-20 Free cholesterol in very small VLDL EFO_0008591 None None DNA methylation Free cholesterol in very small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -5 1.26 0.000078 None Battram-T_free_cholesterol_in_very_small_vldl Gadd DA Generation Scotland 35945220 31/07/2022 FAM174A protein levels (SeqId = 6597-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM174A protein levels (SeqId = 6597-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Membrane protein FAM174A 774 1 Adults (18-65 years) Both European cg01536875 chr2:222291194 2 222291194 EPHA4 Open sea 0.68 0.172 0.000079 None Gadd-DA_fam174a_protein_levels__seqid___6597-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MMP14 protein levels (SeqId = 5002-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MMP14 protein levels (SeqId = 5002-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Matrix metalloproteinase-14 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.448 0.114 0.000079 None Gadd-DA_mmp14_protein_levels__seqid___5002-76__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0325837 0.00825219 0.00007901095 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06301161 chr2:222302347 2 222302347 EPHA4 Open sea -0.0325831 0.00825219 0.00007903531 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14963027 chr2:222385883 2 222385883 EPHA4 Open sea -0.0325778 0.00825219 0.00007924894 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0325776 0.00825219 0.0000792573 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0375441 0.00951527 0.00007994836 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0352728 0.00893998 0.00007999856 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CD247 protein levels (SeqId = 15567-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD247 protein levels (SeqId = 15567-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-cell surface glycoprotein CD3 zeta chain 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.00008 None Gadd-DA_cd247_protein_levels__seqid___15567-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIK3C2A protein levels (SeqId = 14028-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIK3C2A protein levels (SeqId = 14028-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.113 0.00008 None Gadd-DA_pik3c2a_protein_levels__seqid___14028-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 S100A10 protein levels (SeqId = 15318-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 S100A10 protein levels (SeqId = 15318-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein S100-A10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000081 None Gadd-DA_s100a10_protein_levels__seqid___15318-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANKRD1 protein levels (SeqId = 15361-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANKRD1 protein levels (SeqId = 15361-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ankyrin repeat domain-containing protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.448 0.114 0.000081 None Gadd-DA_ankrd1_protein_levels__seqid___15361-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNFSF11 protein levels (SeqId = 14061-48) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFSF11 protein levels (SeqId = 14061-48) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor ligand superfamily member 11 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000081 None Gadd-DA_tnfsf11_protein_levels__seqid___14061-48__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0325117 0.00825221 0.00008194016 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 STX2 protein levels (SeqId = 7738-299) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STX2 protein levels (SeqId = 7738-299) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Syntaxin-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000082 None Gadd-DA_stx2_protein_levels__seqid___7738-299__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.051828 0.0131634 0.00008278851 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 MMP16 protein levels (SeqId = 9719-145) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MMP16 protein levels (SeqId = 9719-145) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Matrix metalloproteinase-16 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000083 None Gadd-DA_mmp16_protein_levels__seqid___9719-145__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MTPAP protein levels (SeqId = 9028-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTPAP protein levels (SeqId = 9028-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Poly(A) RNA polymerase, mitochondrial 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000083 None Gadd-DA_mtpap_protein_levels__seqid___9028-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GAL3ST1 protein levels (SeqId = 8696-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAL3ST1 protein levels (SeqId = 8696-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galactosylceramide sulfotransferase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000083 None Gadd-DA_gal3st1_protein_levels__seqid___8696-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTS protein levels (SeqId = 12014-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTS protein levels (SeqId = 12014-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 6-pyruvoyl tetrahydrobiopterin synthase 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.448 0.114 0.000083 None Gadd-DA_pts_protein_levels__seqid___12014-19__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0446989 0.0113564 0.00008323209 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Lung Cancer None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Lung Cancer Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18364 1 Adults (18-65y) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.014 0.00368 0.000084 None Robert-F-Hillary_Incident_Lung_Cancer_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 GADD45GIP1 protein levels (SeqId = 9302-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GADD45GIP1 protein levels (SeqId = 9302-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth arrest and DNA damage-inducible proteins-interacting protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000084 None Gadd-DA_gadd45gip1_protein_levels__seqid___9302-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EVL protein levels (SeqId = 11656-110) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EVL protein levels (SeqId = 11656-110) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ena/VASP-like protein 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000084 None Gadd-DA_evl_protein_levels__seqid___11656-110__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.0324541 0.00825222 0.00008435775 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea -0.032441 0.00825223 0.00008491837 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Battram T ARIES None 2020-08-20 Triglycerides in very small VLDL EFO_0004530 None None DNA methylation Triglycerides in very small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 680 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -3 0.76 0.000085 None Battram-T_triglycerides_in_very_small_vldl Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25183214 chr2:222360426 2 222360426 EPHA4 Open sea 0.0004 None 0.000085 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 LILRA5 protein levels (SeqId = 7787-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LILRA5 protein levels (SeqId = 7787-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte immunoglobulin-like receptor subfamily A member 5 774 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.84 0.214 0.000086 None Gadd-DA_lilra5_protein_levels__seqid___7787-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FUT2 protein levels (SeqId = 9121-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FUT2 protein levels (SeqId = 9121-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galactoside 2-alpha-L-fucosyltransferase 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000086 None Gadd-DA_fut2_protein_levels__seqid___9121-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CYTH2 protein levels (SeqId = 12533-135) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CYTH2 protein levels (SeqId = 12533-135) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytohesin-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000086 None Gadd-DA_cyth2_protein_levels__seqid___12533-135__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0456398 0.0116193 0.00008607336 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 IFNG protein levels (SeqId = 15346-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFNG protein levels (SeqId = 15346-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon gamma 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000087 None Gadd-DA_ifng_protein_levels__seqid___15346-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLA2G2C protein levels (SeqId = 8850-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLA2G2C protein levels (SeqId = 8850-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Putative inactive group IIC secretory phospholipase A2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000087 None Gadd-DA_pla2g2c_protein_levels__seqid___8850-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLTC protein levels (SeqId = 13711-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLTC protein levels (SeqId = 13711-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Clathrin heavy chain 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000087 None Gadd-DA_cltc_protein_levels__seqid___13711-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00335735 chr2:222355484 2 222355484 EPHA4 Open sea -0.0323924 0.00825224 0.00008702117 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HRK protein levels (SeqId = 8008-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HRK protein levels (SeqId = 8008-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activator of apoptosis harakiri 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000088 None Gadd-DA_hrk_protein_levels__seqid___8008-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SEMA6C protein levels (SeqId = 7202-107) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SEMA6C protein levels (SeqId = 7202-107) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Semaphorin-6C 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.11 0.000089 None Gadd-DA_sema6c_protein_levels__seqid___7202-107__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRB7 protein levels (SeqId = 11281-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRB7 protein levels (SeqId = 11281-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth factor receptor-bound protein 7 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000089 None Gadd-DA_grb7_protein_levels__seqid___11281-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCL2L2 protein levels (SeqId = 13097-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCL2L2 protein levels (SeqId = 13097-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bcl-2-like protein 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.445 0.114 0.000089 None Gadd-DA_bcl2l2_protein_levels__seqid___13097-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SCARF2 protein levels (SeqId = 9925-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCARF2 protein levels (SeqId = 9925-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Scavenger receptor class F member 2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000089 None Gadd-DA_scarf2_protein_levels__seqid___9925-56__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CUL1 protein levels (SeqId = 17797-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CUL1 protein levels (SeqId = 17797-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cullin-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.000089 None Gadd-DA_cul1_protein_levels__seqid___17797-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10517814 chr2:222436149 2 222436149 EPHA4 Island -0.0337939 0.00862356 0.00008940241 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_4 Battram T ARIES None 2020-08-20 Total lipids in medium LDL EFO_0004529 None None DNA methylation Total lipids in medium LDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.49 0.125 0.00009 None Battram-T_total_lipids_in_medium_ldl Gadd DA Generation Scotland 35945220 31/07/2022 RAET1G protein levels (SeqId = 18927-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAET1G protein levels (SeqId = 18927-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UL-16 binding protein 5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.445 0.114 0.00009 None Gadd-DA_raet1g_protein_levels__seqid___18927-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C19orf18 protein levels (SeqId = 9445-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C19orf18 protein levels (SeqId = 9445-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C19orf18 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.45 0.114 0.00009 None Gadd-DA_c19orf18_protein_levels__seqid___9445-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SOS1 protein levels (SeqId = 9923-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SOS1 protein levels (SeqId = 9923-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Son of sevenless homolog 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.113 0.00009 None Gadd-DA_sos1_protein_levels__seqid___9923-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCNB2 protein levels (SeqId = 18208-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCNB2 protein levels (SeqId = 18208-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: G2/mitotic-specific cyclin-B2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.00009 None Gadd-DA_ccnb2_protein_levels__seqid___18208-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09556138 chr2:222285320 2 222285320 EPHA4 Open sea -0.0323175 0.00825226 0.00009036213 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg10835083 chr2:222395101 2 222395101 EPHA4 Open sea 0.00059119 0.00015043 0.0000904 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Battram T ARIES None 2020-08-20 Remnant cholesterol (non-HDL, non-LDL -cholesterol) CHEBI_16113 None None DNA methylation Remnant cholesterol (non-HDL, non-LDL -cholesterol) Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.27 0.07 0.000091 None Battram-T_remnant_cholesterol__non-hdl__non-ldl_-cholesterol_ Gadd DA Generation Scotland 35945220 31/07/2022 TOM1L1 protein levels (SeqId = 13652-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TOM1L1 protein levels (SeqId = 13652-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: TOM1-like protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.445 0.114 0.000091 None Gadd-DA_tom1l1_protein_levels__seqid___13652-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0452685 0.0115665 0.0000912765 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22888848 chr2:222320536 2 222320536 EPHA4 Open sea 0.0322837 0.00825227 0.00009191127 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MAD2L1 protein levels (SeqId = 15313-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAD2L1 protein levels (SeqId = 15313-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitotic spindle assembly checkpoint protein MAD2A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000092 None Gadd-DA_mad2l1_protein_levels__seqid___15313-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea 0.0412185 0.0105396 0.00009239016 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 LRRN1 protein levels (SeqId = 11293-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRRN1 protein levels (SeqId = 11293-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat neuronal protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000093 None Gadd-DA_lrrn1_protein_levels__seqid___11293-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITM2C protein levels (SeqId = 9523-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITM2C protein levels (SeqId = 9523-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integral membrane protein 2C 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000093 None Gadd-DA_itm2c_protein_levels__seqid___9523-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKAA1 protein levels (SeqId = 5183-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKAA1 protein levels (SeqId = 5183-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 5'-AMP-activated protein kinase subunit beta-1|5'-AMP-activated protein kinase catalytic subunit alpha-1|5'-AMP-activated protein kinase subunit gamma-1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.444 0.114 0.000093 None Gadd-DA_prkaa1_protein_levels__seqid___5183-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRLR protein levels (SeqId = 5114-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRLR protein levels (SeqId = 5114-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prolactin receptor 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000093 None Gadd-DA_prlr_protein_levels__seqid___5114-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMURF2 protein levels (SeqId = 13985-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMURF2 protein levels (SeqId = 13985-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase SMURF2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000093 None Gadd-DA_smurf2_protein_levels__seqid___13985-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0322518 0.00825228 0.00009339035 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea 0.0322415 0.00825228 0.00009387561 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TAF10 protein levels (SeqId = 18270-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TAF10 protein levels (SeqId = 18270-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription initiation factor TFIID subunit 10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.113 0.000094 None Gadd-DA_taf10_protein_levels__seqid___18270-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LRRC74A protein levels (SeqId = 8389-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRRC74A protein levels (SeqId = 8389-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat-containing protein 74A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000094 None Gadd-DA_lrrc74a_protein_levels__seqid___8389-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea 0.0322365 0.00825228 0.00009410993 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Fernandez-Jimenez N Pregnancy And Childhood Epigenetics (PACE) None None maternal pre-pregnancy body mass index EFO_0004340 inverse variance-weighted fixed effects meta-analysis https://doi.org/10.5281/zenodo.7314534 DNA methylation maternal pre-pregnancy body mass index Maternal age, parity, maternal education, maternal smoking Beta values kg/m2 Illumina HumanMethylation450 Placenta None 2631 10 Infants Both European, Unclear cg05736236 chr2:222435214 2 222435214 EPHA4 North shore 0.0014 0.00036 0.000095 None Fernandez-Jimenez-N_maternal_pre-pregnancy_body_mass_index_inverse_variance-weighted_fixed_effects_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 SGTB protein levels (SeqId = 18837-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SGTB protein levels (SeqId = 18837-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small glutamine-rich tetratricopeptide repeat-containing protein beta 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000095 None Gadd-DA_sgtb_protein_levels__seqid___18837-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.032207 0.00825229 0.00009551495 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03776464 chr2:222436947 2 222436947 EPHA4 Island 0.0322065 0.00825229 0.00009553671 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T ARIES None 2020-08-20 Esterified cholesterol EFO_0008589 None None DNA methylation Esterified cholesterol Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 673 1 Adults Females European cg05499262 chr2:222437089 2 222437089 EPHA4 Island -0.177 0.045 0.000096 None Battram-T_esterified_cholesterol Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0321837 0.00825229 0.00009663469 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 IFNA2 protein levels (SeqId = 3497-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFNA2 protein levels (SeqId = 3497-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon alpha-2 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000097 None Gadd-DA_ifna2_protein_levels__seqid___3497-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NXPH3 protein levels (SeqId = 6054-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NXPH3 protein levels (SeqId = 6054-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neurexophilin-3 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000097 None Gadd-DA_nxph3_protein_levels__seqid___6054-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KPNA1 protein levels (SeqId = 19587-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KPNA1 protein levels (SeqId = 19587-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Importin subunit alpha-5 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000097 None Gadd-DA_kpna1_protein_levels__seqid___19587-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22475763 chr2:222309041 2 222309041 EPHA4 Open sea -0.0321757 0.0082523 0.00009701945 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg24372550 chr2:222437040 2 222437040 EPHA4 Island 0.133802 0.0343274 0.00009740392 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01269952 chr2:222420472 2 222420472 EPHA4 Open sea 0.0382999 0.00982877 0.00009793968 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ITIH3 protein levels (SeqId = 7145-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITIH3 protein levels (SeqId = 7145-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inter-alpha-trypsin inhibitor heavy chain H3 774 1 Adults (18-65 years) Both European cg09004195 chr2:222323493 2 222323493 EPHA4 Open sea 0.71 0.182 0.000098 None Gadd-DA_itih3_protein_levels__seqid___7145-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADCYAP1 protein levels (SeqId = 8446-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADCYAP1 protein levels (SeqId = 8446-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pituitary adenylate cyclase-activating polypeptide 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000098 None Gadd-DA_adcyap1_protein_levels__seqid___8446-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 OCIAD1 protein levels (SeqId = 16802-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OCIAD1 protein levels (SeqId = 16802-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: OCIA domain-containing protein 1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000098 None Gadd-DA_ociad1_protein_levels__seqid___16802-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSNK2A2 protein levels (SeqId = 13681-173) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSNK2A2 protein levels (SeqId = 13681-173) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Casein kinase II subunit alpha' 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000098 None Gadd-DA_csnk2a2_protein_levels__seqid___13681-173__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21273862 chr2:222384688 2 222384688 EPHA4 Open sea -0.0321537 0.0082523 0.0000980932 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0321491 0.0082523 0.00009831981 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13772414 chr2:222383060 2 222383060 EPHA4 Open sea -0.0453257 0.0116358 0.0000984813 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PSMD10 protein levels (SeqId = 18385-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMD10 protein levels (SeqId = 18385-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 26S proteasome non-ATPase regulatory subunit 10 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000099 None Gadd-DA_psmd10_protein_levels__seqid___18385-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HS3ST4 protein levels (SeqId = 19370-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HS3ST4 protein levels (SeqId = 19370-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 4 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000099 None Gadd-DA_hs3st4_protein_levels__seqid___19370-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS11A protein levels (SeqId = 7231-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS11A protein levels (SeqId = 7231-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 11A 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000099 None Gadd-DA_tmprss11a_protein_levels__seqid___7231-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHEK1 protein levels (SeqId = 2853-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHEK1 protein levels (SeqId = 2853-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase Chk1 774 1 Adults (18-65 years) Both European cg25058917 chr2:222440185 2 222440185 EPHA4 South shore 0.44 0.114 0.000099 None Gadd-DA_chek1_protein_levels__seqid___2853-68__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03850035 chr2:222367110 2 222367110 EPHA4 Open sea -0.0336358 0.0086379 0.00009905261 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03055587 chr2:222384636 2 222384636 EPHA4 Open sea -0.0321327 0.00825231 0.00009912903 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1