author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12972275	chr4:122722461	4	122722461	EXOSC9	Island	-0.0013	0.000098	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06713675	chr4:122721982	4	122721982	EXOSC9	North shore	-0.18561	0.01302	5.9e-32	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02832245	chr4:122722866	4	122722866	EXOSC9	South shore	0.0006	None	8.8e-31	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02832245	chr4:122722866	4	122722866	EXOSC9	South shore	0.01668	0.00124	2.1e-29	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.306082	0.0316102	4.0518740000000003e-22	None	39706196_Hannah-M.-Smith_bmi_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2741768 (gene symbol: EXOSC9)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2741768 (gene symbol: EXOSC9)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg06713675	chr4:122721982	4	122721982	EXOSC9	North shore	None	None	4.5e-18	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2741768__gene_symbol__exosc9__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01578398	chr4:122722532	4	122722532	EXOSC9	Island	0.00035	None	0.0000000000000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.24524	0.0317136	0.0000000000000110811	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0628821	0.00824023	0.00000000000002470418	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13958093	chr4:122722370	4	122722370	EXOSC9	Island	-0.00016	0.000021	0.0000000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0635103	0.00871893	0.0000000000003400968	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	-0.05842	0.00758	0.00000000000066	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0578716	0.00824273	0.000000000002300879	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0575224	0.00870622	0.00000000004055931	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	0.0529439	0.00824499	0.0000000001392411	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24271100	chr4:122722383	4	122722383	EXOSC9	Island	-0.00015	0.000023	0.00000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.197342	0.0316355	0.0000000004535324	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.051366	0.00824567	0.0000000004808398	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0507302	0.00824594	0.0000000007842776	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.049089	0.00824662	0.000000002699056	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0509463	0.00871366	0.000000005120475	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0474646	0.00824727	0.000000008827178	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Umbilical artery	Supplementary table 10	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	Umbilical artery	None	229	1	Infants	Both	European, African, Other	cg06713675	chr4:122721982	4	122721982	EXOSC9	North shore	None	None	0.00000001	None	34569420_Bozack_infant_sex_umbilical_artery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.046884	0.00824749	0.00000001335847	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0466066	0.0082476	0.00000001625511	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg24271100	chr4:122722383	4	122722383	EXOSC9	Island	0.00824	0.0015	0.0000000603	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0439551	0.00824859	0.0000001003269	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0433451	0.00824881	0.0000001503378	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0429603	0.00824895	0.0000001935028	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	1.7	0.32	0.0000002	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg06713675	chr4:122721982	4	122721982	EXOSC9	North shore	-	-	0.000000227	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	0.0422419	0.0082492	0.0000003082151	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0421347	0.00824924	0.000000330176	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	0.0421044	0.00824925	0.0000003366602	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06713675	chr4:122721982	4	122721982	EXOSC9	North shore	-0.042	0.0082	0.00000036	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21703586	chr4:122722613	4	122722613	EXOSC9	Island	-0.000043	0.0000085	0.0000004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	0.228348	0.0453214	0.0000004741475	None	39706196_Hannah-M.-Smith_bmi_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.032	0.00646	0.00000055	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0446016	0.00914539	0.000001088683	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0401459	0.00824992	0.000001149378	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0420671	0.00871033	0.000001382099	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.147954	0.0308169	0.000001590758	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0392698	0.0082502	0.000001955802	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0409693	0.00868528	0.000002414424	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0408686	0.00867714	0.000002500927	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19748678	chr4:122722346	4	122722346	EXOSC9	Island	-0.00021	0.000045	0.0000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0408474	0.00871242	0.000002778205	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.038538	0.00825044	0.000003023656	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.03849	0.00825045	0.00000311041	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ZPLD1 protein levels (SeqId = 5590-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZPLD1 protein levels (SeqId = 5590-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zona pellucida-like domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.288	0.063	0.0000053	None	Gadd-DA_zpld1_protein_levels__seqid___5590-11__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	0.206728	0.0454313	0.00000539229	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg12972275	chr4:122722461	4	122722461	EXOSC9	Island	-0.698275	0.1547	0.0000064	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0403942	0.00910583	0.000009227982	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0363884	0.0082511	0.00001040431	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0383632	0.00870996	0.00001067719	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CLCA2 protein levels (SeqId = 8950-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLCA2 protein levels (SeqId = 8950-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-activated chloride channel regulator 2	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.28	0.063	0.000011	None	Gadd-DA_clca2_protein_levels__seqid___8950-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OSM protein levels (SeqId = 14063-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OSM protein levels (SeqId = 14063-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oncostatin-M	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.28	0.063	0.000012	None	Gadd-DA_osm_protein_levels__seqid___14063-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0377356	0.00871591	0.00001504367	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11133001	chr4:122722982	4	122722982	EXOSC9	South shore	0.00903	0.00204	0.000016	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12972275	chr4:122722461	4	122722461	EXOSC9	Island	-0.0028	0.00066	0.000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	1.8	0.426	0.000016	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0356107	0.00825133	0.00001601048	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0354335	0.00825139	0.00001764087	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19671926	chr4:122722719	4	122722719	EXOSC9	Island	0.00314	0.00071	0.000018	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	NDUFB11 protein levels (SeqId = 7747-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDUFB11 protein levels (SeqId = 7747-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.27	0.063	0.000022	None	Gadd-DA_ndufb11_protein_levels__seqid___7747-47__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01578398	chr4:122722532	4	122722532	EXOSC9	Island	0.0350063	0.00825151	0.00002224869	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DIXDC1 protein levels (SeqId = 13441-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DIXDC1 protein levels (SeqId = 13441-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dixin	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.27	0.063	0.000025	None	Gadd-DA_dixdc1_protein_levels__seqid___13441-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0344974	0.00825166	0.00002923486	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0344168	0.00825168	0.00003051618	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	-0.0342789	0.00825172	0.00003283459	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0341776	0.00825175	0.00003464206	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MASP1 protein levels (SeqId = 3605-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MASP1 protein levels (SeqId = 3605-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mannan-binding lectin serine protease 1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.000035	None	Gadd-DA_masp1_protein_levels__seqid___3605-77__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	-0.0340777	0.00825178	0.0000365185	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SATB1 protein levels (SeqId = 13511-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SATB1 protein levels (SeqId = 13511-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-binding protein SATB1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.000038	None	Gadd-DA_satb1_protein_levels__seqid___13511-29__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0357961	0.00870164	0.00003914618	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	COA3 protein levels (SeqId = 7888-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COA3 protein levels (SeqId = 7888-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.00004	None	Gadd-DA_coa3_protein_levels__seqid___7888-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SDF2 protein levels (SeqId = 15333-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDF2 protein levels (SeqId = 15333-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 2	774	1	Adults (18-65 years)	Both	European	cg05635388	chr4:122721892	4	122721892	EXOSC9	North shore	0.17	0.041	0.00004	None	Gadd-DA_sdf2_protein_levels__seqid___15333-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0356424	0.00870693	0.00004270689	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0337775	0.00825186	0.00004275163	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg25969212	chr4:122722590	4	122722590	EXOSC9	Island	0.168933	0.0414	0.0000453	-	27105112_hiv_infection_neutrophils
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC11 protein levels (SeqId = 9783-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC11 protein levels (SeqId = 9783-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily C member 11	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.000046	None	Gadd-DA_dnajc11_protein_levels__seqid___9783-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BATF protein levels (SeqId = 19227-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BATF protein levels (SeqId = 19227-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Basic leucine zipper transcriptional factor ATF-like	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.000046	None	Gadd-DA_batf_protein_levels__seqid___19227-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NFATC4 protein levels (SeqId = 11560-76)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NFATC4 protein levels (SeqId = 11560-76)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear factor of activated T-cells, cytoplasmic 4	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.26	0.063	0.000047	None	Gadd-DA_nfatc4_protein_levels__seqid___11560-76__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SORCS2 protein levels (SeqId = 4569-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SORCS2 protein levels (SeqId = 4569-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: VPS10 domain-containing receptor SorCS2	774	1	Adults (18-65 years)	Both	European	cg14670597	chr4:122722336	4	122722336	EXOSC9	Island	-0.49	0.121	0.000048	None	Gadd-DA_sorcs2_protein_levels__seqid___4569-52__somascan_protein_measurement
Portales-Casamar E	-	27358653	2016-06-29	Fetal alcohol spectrum disorder	NCIT_C92780	-	Table S1	DNA methylation	Fetal alcohol spectrum disorder	Technical covariates	M values	-	Illumina HumanMethylation450	Buccal	-	206	1	11.4	Both	European,Other	cg01578398	chr4:122722532	4	122722532	EXOSC9	Island	-	-	0.0000486	-	27358653_fetal_alcohol_spectrum_disorder
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01578398	chr4:122722532	4	122722532	EXOSC9	Island	0.00086	None	0.000057	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.0332014	0.00825202	0.00005764538	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0331863	0.00825202	0.00005809435	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KCNN1 protein levels (SeqId = 13539-131)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KCNN1 protein levels (SeqId = 13539-131)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small conductance calcium-activated potassium channel protein 1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.00006	None	Gadd-DA_kcnn1_protein_levels__seqid___13539-131__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DMBT1 protein levels (SeqId = 19212-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DMBT1 protein levels (SeqId = 19212-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Deleted in malignant brain tumors 1 protein	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000062	None	Gadd-DA_dmbt1_protein_levels__seqid___19212-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FOXC2 protein levels (SeqId = 14051-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOXC2 protein levels (SeqId = 14051-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Forkhead box protein C2	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.252	0.063	0.000068	None	Gadd-DA_foxc2_protein_levels__seqid___14051-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18061379	chr4:122725854	4	122725854	EXOSC9	South shelf	-0.0328538	0.00825211	0.00006888048	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	THOC1 protein levels (SeqId = 9875-107)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THOC1 protein levels (SeqId = 9875-107)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: THO complex subunit 1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.251	0.063	0.000074	None	Gadd-DA_thoc1_protein_levels__seqid___9875-107__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SDF2 protein levels (SeqId = 15333-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDF2 protein levels (SeqId = 15333-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 2	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000075	None	Gadd-DA_sdf2_protein_levels__seqid___15333-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	0.0326558	0.00825217	0.00007617669	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17539492	chr4:122721218	4	122721218	EXOSC9	North shore	-0.032544	0.0082522	0.00008061321	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TAC4 protein levels (SeqId = 6468-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAC4 protein levels (SeqId = 6468-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tachykinin-4	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000081	None	Gadd-DA_tac4_protein_levels__seqid___6468-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNMT3L protein levels (SeqId = 19142-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNMT3L protein levels (SeqId = 19142-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA (cytosine-5)-methyltransferase 3-like	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000087	None	Gadd-DA_dnmt3l_protein_levels__seqid___19142-39__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02832245	chr4:122722866	4	122722866	EXOSC9	South shore	-0.0336023	0.00856083	0.00008708128	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRTM1 protein levels (SeqId = 19360-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRTM1 protein levels (SeqId = 19360-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane neuronal protein 1	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000088	None	Gadd-DA_lrrtm1_protein_levels__seqid___19360-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP20 protein levels (SeqId = 15419-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP20 protein levels (SeqId = 15419-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Matrix metalloproteinase-20	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000088	None	Gadd-DA_mmp20_protein_levels__seqid___15419-15__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19748678	chr4:122722346	4	122722346	EXOSC9	Island	-0.889582	0.227	0.0000889	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	CD200 protein levels (SeqId = 5112-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD200 protein levels (SeqId = 5112-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: OX-2 membrane glycoprotein	774	1	Adults (18-65 years)	Both	European	cg11979875	chr4:122721721	4	122721721	EXOSC9	North shore	0.25	0.063	0.000096	None	Gadd-DA_cd200_protein_levels__seqid___5112-73__somascan_protein_measurement
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg05635388	chr4:122721892	4	122721892	EXOSC9	North shore	0.2101976	0.0538903	0.000096	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Gadd DA	Generation Scotland	35945220	31/07/2022	OSM protein levels (SeqId = 14063-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OSM protein levels (SeqId = 14063-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oncostatin-M	774	1	Adults (18-65 years)	Both	European	cg05635388	chr4:122721892	4	122721892	EXOSC9	North shore	0.16	0.041	0.000098	None	Gadd-DA_osm_protein_levels__seqid___14063-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16012408	chr4:122725530	4	122725530	EXOSC9	South shelf	0.0345847	0.00888043	0.00009884228	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2