author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.00092	0.000087	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	-0.00079	0.000093	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13121120	chr11:61584721	11	61584721	FADS1	Island	-0.00012	0.000014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.00085	0.00009	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.27649	0.00347	1.1000000000000001e-149	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13121120	chr11:61584721	11	61584721	FADS1	Island	-0.12445	0.00362	3.2e-84	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.06004	0.00314	1.8e-46	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	-0.0396	0.00215	1.8000000000000002e-44	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.03835	0.00232	9.599999999999999e-39	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-	-	1.44e-35	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.00092	None	1.6999999999999998e-31	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16328381	chr11:61568095	11	61568095	FADS1	Open sea	0.02718	0.00198	2.3000000000000002e-30	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	2.559	0.18199	4.07e-24	-	25282492_fetal_vs_adult_liver
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg07689907	chr11:61582574	11	61582574	FADS1	Island	None	None	1.6000000000000002e-22	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3375545__gene_symbol__fads1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.0801771	0.00822999	2.33152e-22	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.00078	None	1.8e-17	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07709195	chr11:61586015	11	61586015	FADS1	South shore	0.03331	0.00364	8.1e-17	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.02066	0.00226	9.1e-17	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.371369	0.0457565	5.11349e-16	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02085160	chr11:61584616	11	61584616	FADS1	Island	0.000074	None	0.0000000000000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.0635662	0.00823987	0.00000000000001292945	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.364213	0.0477022	0.00000000000002366907	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.0582387	0.00824256	0.000000000001671146	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg25837350	chr11:61584442	11	61584442	FADS1	Island	0.03216	0.0047	0.00000000000864	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0562929	0.00824348	0.000000000008900369	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.0544607	0.00824432	0.00000000004088772	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	-0.0543304	0.00824438	0.00000000004548413	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.0536875	0.00824466	0.00000000007667852	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	main	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.00194	0.0003	0.000000000086	None	33279932_Li-M_schizophrenia_main
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	-0.0535422	0.00824473	0.00000000008621097	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0006	0.000093	0.00000000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-	-	0.000000000469	-	26857698_primary_sjogrens_syndrome_whole_blood
Petersen A-K	KORA F4	24014485	2013-09-06	M02730_gamma-glutamylglutamine	EFO_0004727, EFO_0004725	no snps model	Table S2	M02730_gamma-glutamylglutamine	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	24	0.23	0.00000000084	None	24014485_Petersen-A-K_m02730_gamma-glutamylglutamine_no_snps_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13121120	chr11:61584721	11	61584721	FADS1	Island	0.0001	None	0.00000000096	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0496265	0.0082464	0.000000001808289	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0495695	0.00824642	0.000000001887099	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26256748	chr11:61572476	11	61572476	FADS1	Open sea	-0.23511	0.0395818	0.000000002904628	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.172292	0.0291727	0.000000003568918	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Alvizi L	-	28550290	2017-05-26	Non-syndromic cleft lip and palate	EFO_0003959, HP_0000175	Discovery	Table S1	Non-syndromic cleft lip and palate	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	-	126	1	6	Both	European,Other	cg25837350	chr11:61584442	11	61584442	FADS1	Island	-	-	0.00000000435	-	28550290_nonsyndromic_cleft_lip_and_palate_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25448062	chr11:61580118	11	61580118	FADS1	North shelf	0.00079	None	0.0000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0482601	0.00824695	0.000000004964243	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06405978	chr11:61584654	11	61584654	FADS1	Island	-0.000086	0.000015	0.0000000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0477101	0.00824717	0.000000007397717	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.0475563	0.00824723	0.000000008264627	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.219445	0.0387626	0.00000001525151	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0466274	0.00824759	0.00000001601822	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	adjusted for cell composition	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg06985934	chr11:61584717	11	61584717	FADS1	Island	None	None	0.000000026	None	33279932_Li-M_schizophrenia_adjusted_for_cell_composition
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.0459339	0.00824786	0.00000002604274	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.00012668	2.28e-05	0.0000000348	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg07709195	chr11:61586015	11	61586015	FADS1	South shore	-	-	0.0000000362	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0452687	0.00824811	0.00000004123734	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0032	0.0006	0.000000067	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0023	None	0.00000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Spiers H	-	25650246	2015-02-03	Sex	PATO_0000047	-	Additional file 3	DNA methylation	Sex	Gestational age and technical covariates	Beta values	-	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg05168842	chr11:61584319	11	61584319	FADS1	Island	-0.01102136	0.0021	0.000000112	-	25650246_sex
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25448062	chr11:61580118	11	61580118	FADS1	North shelf	-0.01209	0.0022	0.00000012	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	-0.0436371	0.00824871	0.0000001239544	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0436266	0.00824871	0.0000001248202	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0432496	0.00824885	0.00000016008	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0431692	0.00824887	0.0000001687642	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02085160	chr11:61584616	11	61584616	FADS1	Island	-0.000047	0.000009	0.00000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	-0.299071	0.0572779	0.0000001795292	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.042427	0.00824914	0.0000002735631	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.244848	0.0479179	0.0000003258666	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	-0.328962	0.0648566	0.0000003972317	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0422888	0.00834507	0.0000004079288	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0416617	0.0082494	0.0000004464937	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.0410223	0.00824962	0.0000006679751	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	-0.00007	0.000014	0.00000077	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0404235	0.00824982	0.0000009689991	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	-0.0420967	0.00862216	0.000001059134	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.221974	0.045671	0.000001181856	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0400587	0.00824994	0.000001212406	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg05168842	chr11:61584319	11	61584319	FADS1	Island	-1.241555	0.2603	0.00000185	-	27105112_hiv_infection_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	1.222123	0.2564	0.00000187	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0391655	0.00825024	0.000002081996	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	-0.0391544	0.00825024	0.000002095934	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.03896	0.0082503	0.000002354137	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0388516	0.00825034	0.00000251095	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16688137	chr11:61575219	11	61575219	FADS1	Open sea	0.0388293	0.00825034	0.0000025445	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02085160	chr11:61584616	11	61584616	FADS1	Island	0.00021	None	0.0000027	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	-0.0386017	0.00825042	0.000002912042	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIF protein levels (SeqId = 5248-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIF protein levels (SeqId = 5248-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.56	0.122	0.0000038	None	Gadd-DA_ppif_protein_levels__seqid___5248-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0381155	0.00825057	0.000003874989	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0379843	0.00825061	0.000004183007	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10931343	chr11:61572170	11	61572170	FADS1	Open sea	-0.231845	0.0504888	0.000004419482	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0351704	0.00767391	0.000004618674	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0389259	0.00861243	0.000006239965	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0372424	0.00825084	0.000006418031	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.037716	0.00835736	0.000006444297	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0367336	0.008251	0.000008569457	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0383059	0.00861574	0.000008811023	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0366549	0.00825102	0.000008958558	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.0024	None	0.0000093	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16688137	chr11:61575219	11	61575219	FADS1	Open sea	0.0368402	0.0083103	0.000009357497	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07709195	chr11:61586015	11	61586015	FADS1	South shore	-0.0082	0.0019	0.000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0362515	0.00825114	0.00001123174	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PDIA5 protein levels (SeqId = 5593-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDIA5 protein levels (SeqId = 5593-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase A5	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.53	0.121	0.000013	None	Gadd-DA_pdia5_protein_levels__seqid___5593-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10049260	chr11:61572247	11	61572247	FADS1	Open sea	0.0341987	0.00785777	0.00001356864	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16688137	chr11:61575219	11	61575219	FADS1	Open sea	-0.197923	0.0457284	0.00001511149	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0359789	0.008332	0.00001583677	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg25448062	chr11:61580118	11	61580118	FADS1	North shelf	-0.72	0.168	0.000023	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	-0.0347814	0.00825158	0.00002511312	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CS protein levels (SeqId = 18309-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CS protein levels (SeqId = 18309-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Citrate synthase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.51	0.121	0.000027	None	Gadd-DA_cs_protein_levels__seqid___18309-18__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11606466	chr11:61580877	11	61580877	FADS1	North shore	0.00028	None	0.000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	-0.0344036	0.00825168	0.00003073086	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.110988	0.0266771	0.00003191423	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	-0.0342994	0.00825171	0.00003247989	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HARS protein levels (SeqId = 17450-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HARS protein levels (SeqId = 17450-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histidine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.5	0.122	0.000034	None	Gadd-DA_hars_protein_levels__seqid___17450-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACOT13 protein levels (SeqId = 17675-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACOT13 protein levels (SeqId = 17675-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acyl-coenzyme A thioesterase 13	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.5	0.122	0.000035	None	Gadd-DA_acot13_protein_levels__seqid___17675-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	A1CF protein levels (SeqId = 12423-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	A1CF protein levels (SeqId = 12423-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: APOBEC1 complementation factor	774	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.9	0.217	0.000036	None	Gadd-DA_a1cf_protein_levels__seqid___12423-38__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16688137	chr11:61575219	11	61575219	FADS1	Open sea	0.0341124	0.00827298	0.00003754659	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SH3GL3 protein levels (SeqId = 18318-98)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SH3GL3 protein levels (SeqId = 18318-98)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endophilin-A3	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.5	0.121	0.000038	None	Gadd-DA_sh3gl3_protein_levels__seqid___18318-98__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0338403	0.00825184	0.00004136952	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SH3GL2 protein levels (SeqId = 12499-108)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SH3GL2 protein levels (SeqId = 12499-108)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endophilin-A1	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.5	0.121	0.000043	None	Gadd-DA_sh3gl2_protein_levels__seqid___12499-108__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Estimated degree of fatty acid unsaturation	EFO_0005110	None	None	DNA methylation	Estimated degree of fatty acid unsaturation	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	672	1	Adults	Females	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	2.03	0.49	0.000043	None	Battram-T_estimated_degree_of_fatty_acid_unsaturation
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0336754	0.00825189	0.00004509304	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDT2 protein levels (SeqId = 16583-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDT2 protein levels (SeqId = 16583-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000048	None	Gadd-DA_nudt2_protein_levels__seqid___16583-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0357609	0.0088139	0.00004989578	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DOK2 protein levels (SeqId = 19578-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DOK2 protein levels (SeqId = 19578-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Docking protein 2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000051	None	Gadd-DA_dok2_protein_levels__seqid___19578-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0333883	0.00825197	0.00005234416	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRPSAP2 protein levels (SeqId = 19150-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRPSAP2 protein levels (SeqId = 19150-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoribosyl pyrophosphate synthase-associated protein 2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.122	0.000053	None	Gadd-DA_prpsap2_protein_levels__seqid___19150-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	0.0500195	0.0123748	0.00005325691	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0495193	0.0122522	0.00005334655	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	GRB2 protein levels (SeqId = 5464-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRB2 protein levels (SeqId = 5464-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Growth factor receptor-bound protein 2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.122	0.000056	None	Gadd-DA_grb2_protein_levels__seqid___5464-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DARS2 protein levels (SeqId = 12395-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DARS2 protein levels (SeqId = 12395-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aspartate--tRNA ligase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.122	0.000056	None	Gadd-DA_dars2_protein_levels__seqid___12395-86__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09462826	chr11:61584773	11	61584773	FADS1	South shore	0.0332521	0.00825201	0.00005615864	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	-0.0332458	0.00825201	0.00005634055	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LYN protein levels (SeqId = 3381-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LYN protein levels (SeqId = 3381-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein kinase Lyn	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000057	None	Gadd-DA_lyn_protein_levels__seqid___3381-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	0.0324248	0.0080567	0.00005736425	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	EHMT2 protein levels (SeqId = 5843-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EHMT2 protein levels (SeqId = 5843-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone-lysine N-methyltransferase EHMT2	774	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.87	0.217	0.000059	None	Gadd-DA_ehmt2_protein_levels__seqid___5843-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPP3CA protein levels (SeqId = 4903-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPP3CA protein levels (SeqId = 4903-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcineurin subunit B type 1|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.00006	None	Gadd-DA_ppp3ca_protein_levels__seqid___4903-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MDH2 protein levels (SeqId = 15534-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDH2 protein levels (SeqId = 15534-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Malate dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000061	None	Gadd-DA_mdh2_protein_levels__seqid___15534-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDAC2 protein levels (SeqId = 18897-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDAC2 protein levels (SeqId = 18897-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone deacetylase 2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000062	None	Gadd-DA_hdac2_protein_levels__seqid___18897-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	-0.0330463	0.00825206	0.00006242466	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SYTL4 protein levels (SeqId = 9090-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYTL4 protein levels (SeqId = 9090-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synaptotagmin-like protein 4	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.121	0.000063	None	Gadd-DA_sytl4_protein_levels__seqid___9090-9__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25448062	chr11:61580118	11	61580118	FADS1	North shelf	0.17642	0.044098	0.00006343753	None	39706196_Hannah-M.-Smith_bmi_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	HADH protein levels (SeqId = 17739-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HADH protein levels (SeqId = 17739-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.49	0.122	0.000064	None	Gadd-DA_hadh_protein_levels__seqid___17739-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16328381	chr11:61568095	11	61568095	FADS1	Open sea	0.0329795	0.00825208	0.00006459976	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FAF2 protein levels (SeqId = 9738-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAF2 protein levels (SeqId = 9738-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: FAS-associated factor 2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.000065	None	Gadd-DA_faf2_protein_levels__seqid___9738-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNRNPF protein levels (SeqId = 9764-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNRNPF protein levels (SeqId = 9764-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heterogeneous nuclear ribonucleoprotein F	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000069	None	Gadd-DA_hnrnpf_protein_levels__seqid___9764-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16213375	chr11:61584727	11	61584727	FADS1	Island	-0.0338857	0.00852164	0.00007029239	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	METAP1 protein levels (SeqId = 3210-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	METAP1 protein levels (SeqId = 3210-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Methionine aminopeptidase 1	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.000071	None	Gadd-DA_metap1_protein_levels__seqid___3210-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PGK1 protein levels (SeqId = 5020-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGK1 protein levels (SeqId = 5020-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate kinase 1	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000074	None	Gadd-DA_pgk1_protein_levels__seqid___5020-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAT3 protein levels (SeqId = 10346-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAT3 protein levels (SeqId = 10346-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal transducer and activator of transcription 3	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.000074	None	Gadd-DA_stat3_protein_levels__seqid___10346-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDX1 protein levels (SeqId = 3855-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDX1 protein levels (SeqId = 3855-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxiredoxin-1	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.000075	None	Gadd-DA_prdx1_protein_levels__seqid___3855-56__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07689907	chr11:61582574	11	61582574	FADS1	Island	0.0342635	0.00865035	0.0000750094	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	KPNB1 protein levels (SeqId = 3887-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KPNB1 protein levels (SeqId = 3887-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Importin subunit beta-1	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000076	None	Gadd-DA_kpnb1_protein_levels__seqid___3887-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.0326477	0.00825217	0.00007649301	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HSD17B10 protein levels (SeqId = 4217-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSD17B10 protein levels (SeqId = 4217-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3-hydroxyacyl-CoA dehydrogenase type-2	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.00008	None	Gadd-DA_hsd17b10_protein_levels__seqid___4217-49__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16688137	chr11:61575219	11	61575219	FADS1	Open sea	0.185271	0.0469917	0.00008091088	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.0335018	0.00850169	0.00008165163	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Sharp GC	-	25855720	2015-08-01	Maternal underweight	EFO_0005936	Birth	Additional file 1	DNA methylation	Maternal underweight	Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	601	1	0	Both	European	cg06405978	chr11:61584654	11	61584654	FADS1	Island	0.00982	0.0025	0.0000837	-	25855720_maternal_underweight_birth
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0329063	0.00836532	0.00008404761	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	EFHA1 protein levels (SeqId = 6226-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFHA1 protein levels (SeqId = 6226-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium uptake protein 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.121	0.000085	None	Gadd-DA_efha1_protein_levels__seqid___6226-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRC59 protein levels (SeqId = 19163-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRC59 protein levels (SeqId = 19163-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat-containing protein 59	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000086	None	Gadd-DA_lrrc59_protein_levels__seqid___19163-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UNC45A protein levels (SeqId = 13082-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UNC45A protein levels (SeqId = 13082-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein unc-45 homolog A	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000088	None	Gadd-DA_unc45a_protein_levels__seqid___13082-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2I protein levels (SeqId = 2877-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2I protein levels (SeqId = 2877-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SUMO-conjugating enzyme UBC9	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000089	None	Gadd-DA_ube2i_protein_levels__seqid___2877-3__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Ratio of diacylglycerol to triglycerides	CHEBI_86980, CHEBI_85694, CHEBI_85693, CHEBI_85701, EFO_0004530	None	None	DNA methylation	Ratio of diacylglycerol to triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	644	1	Adults	Females	European	cg16328381	chr11:61568095	11	61568095	FADS1	Open sea	-16	3.9	0.000089	None	Battram-T_ratio_of_diacylglycerol_to_triglycerides
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10515671	chr11:61585899	11	61585899	FADS1	South shore	0.033101	0.00845149	0.00009021729	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	AKT1 protein levels (SeqId = 3392-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKT1 protein levels (SeqId = 3392-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RAC-gamma serine/threonine-protein kinase	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.48	0.122	0.000092	None	Gadd-DA_akt1_protein_levels__seqid___3392-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TRIP10 protein levels (SeqId = 17676-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRIP10 protein levels (SeqId = 17676-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cdc42-interacting protein 4	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.47	0.122	0.000094	None	Gadd-DA_trip10_protein_levels__seqid___17676-13__somascan_protein_measurement
Sammallahti S	PACE	None	None	Maternal anxiety during pregnancy	EFO_0005230, EFO_0002950	Meta-analysis using EPIC-only sites	None	DNA methylation	Maternal anxiety during pregnancy	Sex, Cell composition (reference based), Batch effects, Ancestry (other), Socio-economic position, maternal age	Beta Values	None	Illumina MethylationEPIC	Cord blood	Only EPIC-specific sites (which are available on the Illumina EPIC, but not the Illumina 450k array) were included in this meta-analysis	1221	4	Infants	Both	European, African, Admixed	cg04929437	chr11:61575417	11	61575417	FADS1	Open sea	None	None	0.0000953	None	Sammallahti-S_maternal_anxiety_during_pregnancy_meta-analysis_using_epic-only_sites
Gadd DA	Generation Scotland	35945220	31/07/2022	IDH3G protein levels (SeqId = 19275-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IDH3G protein levels (SeqId = 19275-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg06985934	chr11:61584717	11	61584717	FADS1	Island	0.47	0.122	0.000096	None	Gadd-DA_idh3g_protein_levels__seqid___19275-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06422145	chr11:61579991	11	61579991	FADS1	North shelf	-0.0309994	0.00796082	0.00009904441	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25448062	chr11:61580118	11	61580118	FADS1	North shelf	0.0321157	0.00825231	0.00009997768	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1