author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.00078	0.000076	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0015	0.000093	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.0012	0.0001	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10868875	chr11:61596307	11	61596307	FADS2	Island	0.0004	None	2.4999999999999997e-222	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0015	None	1.2e-144	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.144131	0.00817036	6.173779e-69	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.141279	0.00817376	2.793218e-66	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.0013	None	7e-66	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	FAw3toFA	None	Meta-analysis	Table S2	DNA methylation	FAw3toFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Ratio of omega-3 fatty acids to total fatty acids	5414	4	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	1.7	0.11	3.2000000000000004e-48	None	33413638_Gomez-Alonso-MDC_faw3tofa_meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.11099	0.00562	3.5e-48	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.119327	0.00819758	1.14273e-47	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.116729	0.00820013	1.1195560000000001e-45	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.115835	0.00820099	5.289365e-45	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.11943	0.00663	3.6e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.10818	0.00820812	1.9272960000000002e-39	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0526	0.00322	3.1000000000000004e-38	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.10388	0.0082119	1.73747e-36	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10868875	chr11:61596307	11	61596307	FADS2	Island	0.0014	None	2.2e-35	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.102038	0.00821348	2.9412e-35	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-1.95668	0.09925	7.61e-34	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0962962	0.0082182	1.4346e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0953551	0.00821895	5.505596e-31	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0931894	0.00822064	1.156016e-29	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.00078	None	2.0000000000000002e-29	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Petersen A-K	KORA F4	24014485	2013-09-06	M02730_gamma-glutamylglutamine	EFO_0004727, EFO_0004725	no snps model	Table S2	M02730_gamma-glutamylglutamine	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	470	0.24	9.400000000000001e-28	None	24014485_Petersen-A-K_m02730_gamma-glutamylglutamine_no_snps_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.39098	0.0363338	6.349675e-27	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0880151	0.00822453	1.2551569999999999e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.10519	0.00995027	5.0084619999999996e-26	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0865832	0.00822556	8.093788e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0863688	0.00822572	1.067143e-25	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0978986	0.00935459	1.533781e-25	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0977261	0.00934839	1.730263e-25	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.366261	0.0353024	3.786377e-25	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	FAw3toFA	None	Meta-analysis	Table S2	DNA methylation	FAw3toFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Ratio of omega-3 fatty acids to total fatty acids	5414	4	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	1.5	0.14	4.8e-25	None	33413638_Gomez-Alonso-MDC_faw3tofa_meta-analysis
Petersen A-K	KORA F4	24014485	2013-09-06	M33084_ADSGEGDFXAEGGGVR*	EFO_0004727, EFO_0004725	no snps model	Table S2	M33084_ADSGEGDFXAEGGGVR*	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	11	0.11	1.0000000000000001e-24	None	24014485_Petersen-A-K_m33084_adsgegdfxaegggvr__no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0843485	0.00822715	1.396505e-24	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.358163	0.0354215	5.686045e-24	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0822113	0.00822862	1.9850940000000002e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	FAw3	EFO_0010119	Meta-analysis	Table S2	DNA methylation	FAw3	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Omega-3 fatty acids	5414	4	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	1.47	0.15	3.2000000000000003e-23	None	33413638_Gomez-Alonso-MDC_faw3_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0811319	0.00822935	7.392290000000001e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0809506	0.00822947	9.20382e-23	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.25118	0.0256356	1.304612e-22	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	None	None	2.4e-21	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3375545__gene_symbol__fads1__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	-0.01571	0.00147	2.9e-21	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0778942	0.00823148	3.440213e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.226481	0.0240764	5.708736e-21	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.03353	0.00318	8.5e-21	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.336202	0.036238	1.922898e-20	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0763556	0.00823247	2.020952e-20	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M33084_ADSGEGDFXAEGGGVR*	EFO_0004727, EFO_0004725	no snps model	Table S2	M33084_ADSGEGDFXAEGGGVR*	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	70	0.2	2e-19	None	24014485_Petersen-A-K_m33084_adsgegdfxaegggvr__no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0836913	0.00932544	3.1862189999999995e-19	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0726434	0.00823476	1.2543190000000001e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0718286	0.00823524	3.020652e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0712309	0.0082356	5.720505e-18	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0707176	0.0082359	9.857248e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.28435	0.0332	1.03e-17	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0699913	0.00823632	2.114768e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0694875	0.00823661	3.5749510000000004e-17	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0699071	0.00831739	4.670758e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0753084	0.00896028	4.6809810000000006e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0029	None	7e-17	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0693636	0.0083296	8.990827000000001e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.184299	0.0222208	1.170694e-16	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.044	0.00446	1.3e-16	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	0.00055	0.000067	2.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0675094	0.00823774	2.708632e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0672671	0.00823787	3.457192e-16	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	FAw3	EFO_0010119	Meta-analysis	Table S2	DNA methylation	FAw3	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Omega-3 fatty acids	5414	4	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	1.59	0.2	6.4e-16	None	33413638_Gomez-Alonso-MDC_faw3_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0717208	0.00891569	9.331945e-16	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0659552	0.00823859	0.000000000000001277134	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0659294	0.00823861	0.000000000000001310068	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0655637	0.00823881	0.000000000000001877164	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0652686	0.00823897	0.000000000000002505532	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07591205	chr11:61633557	11	61633557	FADS2	Open sea	0.00076	None	0.0000000000000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0646658	0.00823929	0.00000000000000450138	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0644348	0.00823941	0.000000000000005626767	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0641269	0.00823958	0.000000000000007566088	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.238098	0.0307591	0.00000000000001039925	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-1.9	0.242	0.000000000000014	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0633641	0.00823998	0.0000000000000156656	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0632386	0.00824005	0.0000000000000176448	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg19610905	chr11:61596333	11	61596333	FADS2	Island	None	None	0.000000000000019	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3375545__gene_symbol__fads1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.063066	0.00824014	0.00000000000002077184	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0630491	0.00824014	0.00000000000002110519	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.229149	0.0300384	0.00000000000002490567	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0625544	0.0082404	0.00000000000003360501	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0624251	0.00824047	0.00000000000003792649	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.348447	0.0460072	0.00000000000003798593	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-1.27	0.168	0.000000000000042	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.071288	0.0094284	0.0000000000000423744	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M02730_gamma-glutamylglutamine	EFO_0004727, EFO_0004725	no snps model	Table S2	M02730_gamma-glutamylglutamine	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	11	0.14	0.000000000000044	None	24014485_Petersen-A-K_m02730_gamma-glutamylglutamine_no_snps_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.294501	0.0390083	0.00000000000004567883	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0619288	0.00824072	0.00000000000006020727	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.00103456	0.00013611	0.0000000000000643	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.25285	0.0337914	0.0000000000000763161	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.15691	0.0210634	0.00000000000009795348	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0608012	0.0082413	0.0000000000001697679	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0606447	0.00824137	0.0000000000001957594	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.060632	0.00824138	0.0000000000001980274	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0605067	0.00824144	0.0000000000002218837	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0604489	0.00824147	0.0000000000002338248	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0601354	0.00824163	0.0000000000003104033	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.060001	0.0082417	0.0000000000003503052	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0674837	0.00927153	0.0000000000003544653	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.141596	0.0194834	0.0000000000003809738	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0594491	0.00824197	0.0000000000005742133	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0592536	0.00824206	0.0000000000006833469	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0588538	0.00824226	0.0000000000009736452	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0680409	0.00957339	0.000000000001238012	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0584361	0.00824246	0.000000000001406041	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0580863	0.00824263	0.000000000001908836	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0580335	0.00824266	0.000000000001998625	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0579176	0.00824271	0.000000000002210714	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0579117	0.00824271	0.000000000002222027	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0577866	0.00824277	0.000000000002477012	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.031	0.00382	0.0000000000025	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0577548	0.00824279	0.000000000002546257	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Alvizi L	-	28550290	2017-05-26	Non-syndromic cleft lip and palate	EFO_0003959, HP_0000175	Discovery	Table S1	Non-syndromic cleft lip and palate	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	-	126	1	6	Both	European,Other	cg14911132	chr11:61596755	11	61596755	FADS2	South shore	-	-	0.00000000000363	-	28550290_nonsyndromic_cleft_lip_and_palate_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.286491	0.0411911	0.00000000000364106	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0573141	0.008243	0.000000000003725384	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0019	0.00027	0.0000000000045	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0570681	0.00824312	0.000000000004601424	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0605142	0.00875943	0.000000000005101474	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0566505	0.00824331	0.000000000006572434	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg19610905	chr11:61596333	11	61596333	FADS2	Island	-	-	0.0000000000089	-	24500968_pancreatic_ductal_adenocarcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0584019	0.00858632	0.00000000001073611	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-	-	0.0000000000122	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0580727	0.008583	0.00000000001373946	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0569266	0.00845017	0.00000000001680067	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.055446	0.00824387	0.00000000001811829	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0553123	0.00823074	0.00000000001881574	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0550376	0.00824406	0.00000000002543142	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.056325	0.00844253	0.00000000002621352	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.00088142	0.00013128	0.0000000000309	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0547712	0.00824418	0.0000000000316852	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0609012	0.0091678	0.00000000003183178	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	DHA	CHEBI_36005	Meta-analysis	Table S2	DNA methylation	DHA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	22:6, docosahexaenoic acid	5414	4	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	1.56	0.23	0.000000000033	None	33413638_Gomez-Alonso-MDC_dha_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0547166	0.0082442	0.00000000003314128	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0544066	0.00824434	0.00000000004273628	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0543593	0.00824436	0.0000000000444244	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0540934	0.00824448	0.00000000005518017	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	0.181051	0.0276181	0.00000000005694246	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0539372	0.00824455	0.00000000006264377	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0539102	0.00824456	0.00000000006403337	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0538992	0.00824457	0.0000000000646066	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	DHAtoFA	None	Meta-analysis	Table S2	DNA methylation	DHAtoFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Ratio of 22:6 docosahexaenoic acid to total fatty acids	5414	4	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	1.77	0.271	0.000000000065	None	33413638_Gomez-Alonso-MDC_dhatofa_meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0012	0.00018	0.000000000067	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0537606	0.00824463	0.00000000007228008	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05698098	chr11:61595494	11	61595494	FADS2	Island	-0.00051	0.000078	0.000000000082	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	-0.01426	0.00208	0.000000000085	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.119783	0.0184448	0.00000000008566958	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0615953	0.009488	0.00000000008747677	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0534568	0.00824477	0.00000000009234363	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0533849	0.0082448	0.0000000000978412	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0532858	0.00824484	0.000000000105937	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0624205	0.0096621	0.0000000001077649	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0617233	0.00955465	0.0000000001079826	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	1.5	0.236	0.00000000014	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0528968	0.00824501	0.0000000001445626	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg06781209	chr11:61594997	11	61594997	FADS2	Island	None	None	0.00000000018	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3375545__gene_symbol__fads1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0525905	0.00824515	0.000000000184365	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0610538	0.00958579	0.0000000001956836	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0516531	0.00815327	0.000000000243856	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0602927	0.00954551	0.0000000002755509	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.213224	0.0338848	0.0000000003196463	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0518871	0.00824545	0.0000000003206074	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0517175	0.00824552	0.0000000003659917	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0580925	0.00927643	0.0000000003897316	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.13694	0.0219	0.000000000399	-	25650246_gestational_age
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	DHAtoFA	None	Meta-analysis	Table S2	DNA methylation	DHAtoFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Ratio of 22:6 docosahexaenoic acid to total fatty acids	5414	4	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	1.56	0.249	0.00000000041	None	33413638_Gomez-Alonso-MDC_dhatofa_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0582807	0.00935556	0.0000000004806392	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-1.04	0.168	0.0000000006	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Petersen A-K	KORA F4	24014485	2013-09-06	M32492_caprylate_8:0	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32492_caprylate_8:0	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	5.2	0.13	0.00000000061	None	24014485_Petersen-A-K_m32492_caprylate_8_0_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0508308	0.0082459	0.0000000007261801	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23760165	chr11:61595485	11	61595485	FADS2	Island	-0.000081	0.000013	0.00000000078	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Petersen A-K	KORA F4	24014485	2013-09-06	M33084_ADSGEGDFXAEGGGVR*	EFO_0004727, EFO_0004725	no snps model	Table S2	M33084_ADSGEGDFXAEGGGVR*	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	5	0.13	0.00000000081	None	24014485_Petersen-A-K_m33084_adsgegdfxaegggvr__no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0504141	0.00824607	0.000000000998103	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0583797	0.00957844	0.00000000112245	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0575704	0.00944702	0.000000001128665	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0582296	0.00957245	0.000000001208594	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0580715	0.0095485	0.00000000121832	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0500654	0.00824622	0.000000001299919	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0498998	0.00824629	0.00000000147282	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.052632	0.00869782	0.000000001472957	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.04987	0.0082463	0.000000001506273	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0498493	0.00824631	0.000000001529934	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0587484	0.00972986	0.000000001598636	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0525059	0.00869724	0.000000001607225	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-	-	0.00000000164	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.049432	0.00824648	0.00000000209139	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0500004	0.00834278	0.000000002105	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0493687	0.0082465	0.000000002192438	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0493596	0.00824651	0.000000002207354	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0497331	0.00834178	0.000000002550157	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.04895	0.00824667	0.000000002991488	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0487309	0.00824676	0.000000003516107	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0546527	0.00926639	0.000000003761585	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.04861	0.00824681	0.000000003843053	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0514149	0.00875015	0.000000004297324	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0484561	0.00824687	0.000000004301953	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.0026	None	0.0000000047	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0482582	0.00824695	0.000000004971198	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.048233	0.00824696	0.000000005063631	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0594111	0.0101592	0.000000005080531	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.240015	0.0410836	0.000000005241647	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0481643	0.00824699	0.000000005323146	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0481129	0.00824701	0.000000005525933	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0479778	0.00824706	0.000000006095603	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3375545 (gene symbol: FADS1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	None	None	0.0000000062	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3375545__gene_symbol__fads1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0476029	0.00824721	0.000000007991977	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg10868875	chr11:61596307	11	61596307	FADS2	Island	-	-	0.00000000833	-	24500968_pancreatic_ductal_adenocarcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.052804	0.00920141	0.000000009729849	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0473206	0.00824732	0.000000009787162	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.148708	0.0260032	0.00000001089297	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0470855	0.00824741	0.00000001157552	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0519138	0.00910174	0.00000001194849	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0544296	0.00956344	0.00000001283974	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0468581	0.0082475	0.00000001360591	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.152638	0.0268837	0.00000001386926	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.0497508	0.00879794	0.00000001589235	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	0.0025	0.00044	0.000000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0464324	0.00824767	0.00000001837628	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0462107	0.00824775	0.00000002146797	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0461417	0.00824778	0.00000002252923	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0467131	0.00835111	0.00000002263381	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0460731	0.0082478	0.00000002363545	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0458616	0.00824788	0.00000002738417	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0510979	0.00919072	0.00000002749177	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.178751	0.0321548	0.00000002749932	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.045811	0.0082479	0.00000002836297	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08707306	chr11:61621828	11	61621828	FADS2	Open sea	-0.249146	0.0448741	0.00000002861647	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.243543	0.0438802	0.00000002893699	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.209596	0.03782	0.00000003032647	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.014	0.00236	0.000000032	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0456005	0.00824798	0.00000003281513	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0552225	0.0100256	0.00000003687989	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0454233	0.00824805	0.00000003708098	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0453397	0.00824808	0.00000003927516	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0500134	0.00910731	0.00000004050036	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0452645	0.00824811	0.00000004135746	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0615243	0.0112121	0.00000004148546	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0513289	0.00935723	0.00000004191743	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.022	0.00368	0.000000042	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0451978	0.00824813	0.00000004329218	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0451725	0.00824814	0.00000004404955	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10069985	chr11:61619019	11	61619019	FADS2	Open sea	-0.0451054	0.00824817	0.00000004611794	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.155779	0.0285265	0.00000004800439	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	0.0604281	0.0110828	0.00000005036922	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0449644	0.00824822	0.00000005077935	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0449622	0.00824822	0.00000005085553	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.239657	0.0440449	0.00000005360565	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14911132	chr11:61596755	11	61596755	FADS2	South shore	0.00054	None	0.000000054	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0506127	0.00932416	0.00000005785496	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0446468	0.00824834	0.00000006301232	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0444699	0.0082484	0.00000007101938	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0504642	0.0093744	0.00000007430327	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0510826	0.00949989	0.00000007682121	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0478638	0.00896002	0.00000009333716	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0439175	0.00824861	0.000000102876	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00264176	chr11:61612775	11	61612775	FADS2	Open sea	-0.185283	0.0348543	0.0000001073663	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0438822	0.00826793	0.0000001127446	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02563962	chr11:61595550	11	61595550	FADS2	Island	0.00039	0.000074	0.00000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0436362	0.00824871	0.000000124033	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0429195	0.00813225	0.0000001326896	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0493892	0.00937116	0.0000001381052	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0434294	0.00824878	0.0000001422059	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.224962	0.042883	0.0000001572197	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0432308	0.00824885	0.0000001620754	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.240175	0.0458876	0.0000001677343	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0431776	0.00824887	0.0000001678362	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.0541542	0.0103509	0.000000170138	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-3.25	0.614	0.00000018	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0474979	0.00912157	0.0000001942958	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0963451	0.0185116	0.0000001965485	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0467984	0.00902041	0.0000002153338	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0427811	0.00824901	0.0000002174694	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.0427095	0.00827948	0.000000252212	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0425267	0.0082491	0.0000002565022	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.04264	0.00827967	0.0000002639079	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-1	0.195	0.00000028	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0423284	0.00824917	0.0000002915261	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0422997	0.00824918	0.0000002969655	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.66	0.13	0.00000032	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0421155	0.00824925	0.0000003342755	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.219612	0.0430411	0.0000003387632	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.140768	0.0276313	0.000000353085	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0468769	0.00920435	0.0000003569848	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0468174	0.00919556	0.0000003600259	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.085	0.0167	0.00000038	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0418113	0.00824935	0.0000004059925	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10069985	chr11:61619019	11	61619019	FADS2	Open sea	-0.0418003	0.00824936	0.0000004088311	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0420882	0.00831937	0.0000004264191	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.170955	0.0337947	0.0000004266159	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0416709	0.0082494	0.0000004438754	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0470432	0.00931601	0.0000004477916	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07999042	chr11:61598930	11	61598930	FADS2	South shelf	-0.00826	0.00158	0.00000047	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0415691	0.00824943	0.0000004734721	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-1.2	0.248	0.00000049	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.041155	0.00817802	0.0000004901421	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0481891	0.00958689	0.0000005052441	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19852225	chr11:61621805	11	61621805	FADS2	Open sea	0.0449249	0.00894442	0.0000005155621	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.184393	0.0367308	0.0000005215456	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22295169	chr11:61615526	11	61615526	FADS2	Open sea	0.0414109	0.00824949	0.0000005232751	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0413661	0.0082495	0.0000005382896	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0477791	0.00953485	0.0000005477991	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0479467	0.00957001	0.0000005503395	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0411811	0.00822034	0.0000005516207	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.0412544	0.00824954	0.0000005774874	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0412369	0.00824955	0.0000005838691	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0473731	0.00948926	0.0000006035252	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0466167	0.0093519	0.000000627575	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0410703	0.00824961	0.0000006482279	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0394905	0.00794231	0.0000006695512	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0409776	0.00824964	0.0000006869155	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0408929	0.00824967	0.0000007242115	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.143568	0.0289735	0.0000007292345	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.18155	0.0366476	0.0000007341216	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0467675	0.00944933	0.0000007531147	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0408188	0.00824969	0.0000007584281	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0408094	0.00824969	0.0000007628854	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0425439	0.00860786	0.0000007799862	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0419382	0.00849242	0.0000007967137	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22295169	chr11:61615526	11	61615526	FADS2	Open sea	-0.231153	0.046819	0.0000007996529	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.18701	0.0379352	0.0000008306762	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0018	None	0.00000089	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.022	0.00457	0.0000009	None	Robert-F-Hillary_Incident_COPD_Basic_model
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-3.57	0.718	0.00000092	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.150469	0.0306856	0.0000009492347	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0404567	0.00824981	0.0000009493454	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07999042	chr11:61598930	11	61598930	FADS2	South shelf	-0.209731	0.0428097	0.0000009708693	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0404131	0.00824983	0.0000009751906	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0403472	0.00824985	0.000001015624	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0403415	0.00824985	0.000001019221	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0468317	0.00958253	0.000001033638	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0456002	0.00935386	0.000001099366	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0401974	0.0082499	0.000001113612	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0454959	0.00934876	0.000001147614	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0396121	0.00817461	0.000001274247	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0399773	0.00824997	0.000001274274	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.128271	0.0265296	0.000001342268	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	-0.0398596	0.00825001	0.000001369053	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Ma J	CHARGE	32525743	2020-08-01	Healthy eating	EFO_0002755	European meta-analysis	Table 1	DNA methylation	Healthy eating	Age, sex, energy intake, cell composition (reference based), batch effects	Beta values	Alternative Healthy Eating Index	Illumina HumanMethylation450	Whole blood, CD4+ T-cells, CD14+ monocytes	See supplement of paper for details on diet scores	6662	5	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.003	0.001	0.0000015	None	32525743_Ma-J_healthy_eating_european_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0562654	0.0117	0.00000153182	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0399456	0.00831674	0.000001578275	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.0396038	0.00825009	0.000001599086	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0395952	0.0082501	0.000001607391	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0395305	0.00825012	0.000001671528	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10069985	chr11:61619019	11	61619019	FADS2	Open sea	-0.0428544	0.00894389	0.000001671817	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0395299	0.00825012	0.000001672112	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0394882	0.00825013	0.000001714798	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0558893	0.011697	0.000001786885	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0476011	0.00996474	0.000001796975	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0089	0.0019	0.0000018	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0393515	0.00825018	0.000001861994	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.021	0.00432	0.0000019	None	Robert-F-Hillary_Incident_COPD_Basic_model
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.00056333	0.00011763	0.00000191	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02563962	chr11:61595550	11	61595550	FADS2	Island	0.0023	0.00048	0.000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-4.28	0.881	0.000002	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.86	0.181	0.000002	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0393794	0.00828109	0.000002000019	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	-0.0392135	0.00825022	0.000002022932	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.00016	0.000033	0.0000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0433466	0.00914439	0.000002154773	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0438306	0.00925326	0.000002191846	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10069985	chr11:61619019	11	61619019	FADS2	Open sea	-0.0393503	0.00831211	0.000002220922	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.12432	0.0262921	0.000002280466	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0433359	0.00918291	0.000002389738	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0389143	0.00825032	0.000002419053	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0388581	0.00825034	0.000002501374	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0502729	0.0107508	0.00000294836	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0438153	0.00937358	0.000002975216	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0392667	0.00840321	0.000002997285	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00614641	chr11:61596405	11	61596405	FADS2	Island	0.00066	None	0.0000032	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.043507	0.00934242	0.000003237812	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10069985	chr11:61619019	11	61619019	FADS2	Open sea	-0.0386463	0.00830326	0.000003278397	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.0382521	0.00825053	0.000003577315	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg05816884	chr11:61595492	11	61595492	FADS2	Island	0.1467496	0.0317116	0.000003699	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0602439	0.0130207	0.000003745869	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0416581	0.00900956	0.000003800697	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0410261	0.00888312	0.000003899471	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0381024	0.00825058	0.00000390465	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.038085	0.00825058	0.000003944433	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0380524	0.00825059	0.000004020322	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.03843	0.00833591	0.00000405725	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.032	0.00689	0.0000041	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0379113	0.00825064	0.000004364444	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0418912	0.0091197	0.000004395259	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.037883	0.00825064	0.00000443688	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0378801	0.00825065	0.000004444237	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0437275	0.00956141	0.000004839628	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0436837	0.00956256	0.000004959367	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0416117	0.00910906	0.000004960084	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0423818	0.00927911	0.000004977419	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0375657	0.00825074	0.000005331032	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0425271	0.0093516	0.000005470146	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02563962	chr11:61595550	11	61595550	FADS2	Island	0.0374859	0.00825077	0.000005581749	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0374559	0.00825078	0.000005678606	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0374543	0.00825078	0.00000568404	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KLC1 protein levels (SeqId = 12656-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLC1 protein levels (SeqId = 12656-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kinesin light chain 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	1	0.221	0.0000057	None	Gadd-DA_klc1_protein_levels__seqid___12656-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	0.0374197	0.00825079	0.000005798053	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07731404	chr11:61622317	11	61622317	FADS2	Open sea	0.175172	0.0386719	0.000005946649	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.121663	0.0268719	0.00000600771	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0373509	0.00825081	0.000006031477	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.037328	0.00825082	0.000006111281	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0372482	0.00825084	0.000006397022	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0372276	0.00825085	0.000006472667	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.121518	0.0269546	0.000006579099	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0422234	0.00937001	0.000006650028	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	0.0499646	0.0111112	0.000006944422	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.115366	0.0256828	0.000007101019	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0370534	0.0082509	0.000007148776	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.037022	0.00825091	0.000007277614	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0370031	0.00825092	0.000007356316	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0369792	0.00825092	0.000007456832	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.00089	0.0002	0.0000075	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	DHA	CHEBI_36005	Meta-analysis	Table S2	DNA methylation	DHA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	22:6, docosahexaenoic acid	5414	4	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	1.68	0.37	0.0000076	None	33413638_Gomez-Alonso-MDC_dha_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0395692	0.00884388	0.000007727987	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07731404	chr11:61622317	11	61622317	FADS2	Open sea	0.173245	0.0387611	0.000007888236	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0431366	0.0096515	0.000007902131	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0426969	0.0095544	0.000007924198	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.058757	0.013169	0.000008188846	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0368138	0.00825097	0.000008189599	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	UnSat	None	Meta-analysis	Table S2	DNA methylation	UnSat	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Estimated degree of unsaturation	5414	4	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.31	0.07	0.0000082	None	33413638_Gomez-Alonso-MDC_unsat_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0368098	0.00825098	0.000008208055	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0417013	0.00936779	0.000008587975	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0475868	0.0106988	0.000008736848	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0366945	0.00825101	0.000008760673	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0364418	0.00819642	0.000008809963	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.038718	0.00871157	0.000008877101	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0366076	0.00825104	0.000009200063	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0402787	0.00908634	0.000009365339	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	0.042652	0.00963023	0.000009537146	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0415082	0.00938237	0.000009756092	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0025	0.00057	0.0000098	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg22295169	chr11:61615526	11	61615526	FADS2	Open sea	-0.217336	0.0491956	0.00001002939	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0366134	0.00828934	0.00001008335	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0394642	0.00894223	0.00001025628	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0445094	0.0100862	0.00001027287	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.042352	0.00959794	0.00001028607	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	0.0363732	0.00825111	0.00001049365	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0422498	0.00958741	0.00001056573	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0363451	0.00825112	0.00001065995	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0365517	0.00830126	0.00001074462	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	-0.0363076	0.00825113	0.00001088565	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.0376119	0.00855178	0.00001099542	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CNPY3 protein levels (SeqId = 17327-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNPY3 protein levels (SeqId = 17327-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein canopy homolog 3	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.98	0.222	0.000011	None	Gadd-DA_cnpy3_protein_levels__seqid___17327-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0420071	0.00957546	0.00001157506	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0391777	0.00894043	0.00001183666	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0505899	0.0115666	0.00001229524	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	-0.0364417	0.00833192	0.00001229755	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0364223	0.00832858	0.00001232967	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.0360789	0.0082512	0.00001236377	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	-0.0360493	0.0082512	0.0000125691	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0360389	0.00825121	0.00001264165	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	0.0360375	0.00825121	0.00001265162	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0409414	0.00938223	0.00001287488	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	0.0378969	0.00868813	0.00001298057	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.022	0.00506	0.000013	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0408629	0.00937199	0.00001308855	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0374655	0.00860431	0.0000134414	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.037884	0.00870749	0.00001365981	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0358012	0.00822915	0.00001367245	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Cardenas A	Project Viva	31300640	Jul 12, 2019	current asthma	MONDO_0004979	None	Table 3, Supplementary Data 1	DNA methylation	current asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	463	1	Children	Both	Other	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-2.79	0.635	0.000014	None	31300640_Cardenas-A_current_asthma
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0690177	0.0158845	0.00001400863	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	-0.130964	0.0301742	0.00001430809	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0364346	0.00839851	0.00001445977	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.038883	0.00896681	0.00001458537	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	DOK2 protein levels (SeqId = 14246-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DOK2 protein levels (SeqId = 14246-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Docking protein 2	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.96	0.221	0.000015	None	Gadd-DA_dok2_protein_levels__seqid___14246-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0357074	0.00825131	0.00001518217	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	allergic asthma	MONDO_0004784	None	Supplementary Data 3	DNA methylation	allergic asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	277	1	Children	Both	Other	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-3.46	0.787	0.000016	SE manually calculated	31300640_Cardenas-A_allergic_asthma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0385068	0.00892327	0.00001604142	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0436627	0.0101192	0.00001607592	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0386075	0.00895149	0.00001621317	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0355795	0.00825134	0.00001628652	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0386376	0.00896604	0.00001648152	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.00429	0.001	0.000017	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.121828	0.0283766	0.0000176999	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0413884	0.00964296	0.00001781443	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	GATM protein levels (SeqId = 18188-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GATM protein levels (SeqId = 18188-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycine amidinotransferase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.95	0.222	0.000018	None	Gadd-DA_gatm_protein_levels__seqid___18188-12__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.040216	0.00937863	0.0000181404	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg07591205	chr11:61633557	11	61633557	FADS2	Open sea	-0.983716	0.23	0.0000189	-	27105112_hiv_infection_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.027	0.00634	0.000019	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	LMAN2L protein levels (SeqId = 8013-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LMAN2L protein levels (SeqId = 8013-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: VIP36-like protein	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.95	0.222	0.000019	None	Gadd-DA_lman2l_protein_levels__seqid___8013-9__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.14047	0.0328406	0.00001901036	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.03526	0.00825144	0.00001939095	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.10237	0.0240095	0.00002020291	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0399819	0.00937791	0.00002025884	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0351771	0.00825146	0.00002028364	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	-0.0472958	0.0111056	0.00002068621	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.113282	0.0266264	0.00002105648	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0351039	0.00825148	0.00002110521	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.035095	0.00825149	0.00002120707	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.0352919	0.00829851	0.00002124212	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0350414	0.0082515	0.00002183073	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKAA2 protein levels (SeqId = 5245-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKAA2 protein levels (SeqId = 5245-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 5'-AMP-activated protein kinase subunit beta-2|5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase subunit gamma-1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.94	0.221	0.000022	None	Gadd-DA_prkaa2_protein_levels__seqid___5245-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.035013	0.00825151	0.00002216857	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0349672	0.00825152	0.00002272358	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg02563962	chr11:61595550	11	61595550	FADS2	Island	0.138913	0.0329	0.0000236	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0384005	0.00908576	0.00002388385	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB113 protein levels (SeqId = 13374-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB113 protein levels (SeqId = 13374-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 113	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.939	0.222	0.000024	None	Gadd-DA_defb113_protein_levels__seqid___13374-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0366236	0.00867295	0.00002428102	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0359053	0.0085107	0.00002470377	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FLII protein levels (SeqId = 12677-164)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLII protein levels (SeqId = 12677-164)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein flightless-1 homolog	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.93	0.221	0.000025	None	Gadd-DA_flii_protein_levels__seqid___12677-164__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0347872	0.00825157	0.00002503574	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.078847	0.01871	0.00002519641	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.0364596	0.00865136	0.00002520311	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.194215	0.0461057	0.00002539021	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0347369	0.00825159	0.00002572032	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0347026	0.0082516	0.00002619778	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0346933	0.0082516	0.00002632924	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0346697	0.00825161	0.00002666327	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.194335	0.0462565	0.00002667203	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.124315	0.0296346	0.00002743193	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	PGAM1 protein levels (SeqId = 3896-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGAM1 protein levels (SeqId = 3896-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate mutase 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.93	0.222	0.000028	None	Gadd-DA_pgam1_protein_levels__seqid___3896-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0415959	0.00992999	0.00002819327	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0479226	0.0114431	0.00002831987	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0344102	0.00822759	0.00002902672	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0402009	0.00961399	0.00002912767	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0344793	0.00825166	0.00002951725	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0344694	0.00825167	0.00002967399	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	-0.0344675	0.00825167	0.00002970413	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0344531	0.00825167	0.0000299327	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RMDN1 protein levels (SeqId = 7096-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RMDN1 protein levels (SeqId = 7096-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulator of microtubule dynamics protein 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.93	0.222	0.00003	None	Gadd-DA_rmdn1_protein_levels__seqid___7096-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0344415	0.00825167	0.00003011745	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.0406621	0.0097489	0.00003050921	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0343994	0.00825168	0.00003080035	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0365214	0.00877965	0.00003203674	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	0.034308	0.00825171	0.00003233192	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0387739	0.00934118	0.00003330964	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0342456	0.00825173	0.00003341799	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.0346456	0.00837301	0.00003526628	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0341399	0.00825176	0.00003533947	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0341346	0.00825176	0.00003543878	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0387125	0.00935984	0.00003553506	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23713032	chr11:61629366	11	61629366	FADS2	Open sea	-0.16221	0.0392285	0.00003565293	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.033	0.00805	0.000036	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	TARS protein levels (SeqId = 18186-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TARS protein levels (SeqId = 18186-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Threonine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.92	0.222	0.000036	None	Gadd-DA_tars_protein_levels__seqid___18186-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	0.0340899	0.00825177	0.00003628482	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22796604	chr11:61602232	11	61602232	FADS2	Open sea	-0.0391219	0.00947884	0.00003690966	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB4A protein levels (SeqId = 16883-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB4A protein levels (SeqId = 16883-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-4A	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.92	0.222	0.000037	None	Gadd-DA_rab4a_protein_levels__seqid___16883-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLC30A5 protein levels (SeqId = 9594-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLC30A5 protein levels (SeqId = 9594-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc transporter 5	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.91	0.221	0.000037	None	Gadd-DA_slc30a5_protein_levels__seqid___9594-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0340112	0.00825179	0.00003781905	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0339389	0.00825181	0.00003928574	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0372196	0.00905411	0.00003964435	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22295169	chr11:61615526	11	61615526	FADS2	Open sea	-0.201523	0.0490355	0.0000397859	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	0.03535	0.00863132	0.00004234298	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0405455	0.00990194	0.00004249873	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0337788	0.00825186	0.0000427219	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PGAM2 protein levels (SeqId = 15524-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGAM2 protein levels (SeqId = 15524-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate mutase 2	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.909	0.222	0.000043	None	Gadd-DA_pgam2_protein_levels__seqid___15524-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACAT2 protein levels (SeqId = 17341-89)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACAT2 protein levels (SeqId = 17341-89)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acetyl-CoA acetyltransferase, cytosolic	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.9	0.221	0.000044	None	Gadd-DA_acat2_protein_levels__seqid___17341-89__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HIBCH protein levels (SeqId = 12396-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HIBCH protein levels (SeqId = 12396-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.91	0.222	0.000044	None	Gadd-DA_hibch_protein_levels__seqid___12396-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MESDC2 protein levels (SeqId = 15299-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MESDC2 protein levels (SeqId = 15299-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: LRP chaperone MESD	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.91	0.222	0.000044	None	Gadd-DA_mesdc2_protein_levels__seqid___15299-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.53	0.13	0.000044	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0371787	0.00909858	0.00004408059	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.0343354	0.00840649	0.00004442648	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0336915	0.00825188	0.00004471461	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LST1 protein levels (SeqId = 9531-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LST1 protein levels (SeqId = 9531-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte-specific transcript 1 protein	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.9	0.222	0.000045	None	Gadd-DA_lst1_protein_levels__seqid___9531-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0341361	0.00836818	0.00004541415	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0336135	0.00825191	0.00004657064	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.01587	0.00381	0.000047	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	ARIES	None	2020-08-20	Ratio of 18:2 linoleic acid to total fatty acids	EFO_0006807, EFO_0005110	None	None	DNA methylation	Ratio of 18:2 linoleic acid to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	-0.044	0.0107	0.000047	None	Battram-T_ratio_of_18_2_linoleic_acid_to_total_fatty_acids
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0382458	0.00939485	0.00004707041	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	-0.0335645	0.00825192	0.00004777378	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	-0.0335534	0.00825192	0.00004804957	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0335277	0.00825193	0.00004869465	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP7 protein levels (SeqId = 9288-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP7 protein levels (SeqId = 9288-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP7	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.9	0.222	0.000051	None	Gadd-DA_fkbp7_protein_levels__seqid___9288-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	-0.0334135	0.00825196	0.00005166541	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.03792	0.0093658	0.00005175102	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	STX12 protein levels (SeqId = 10418-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STX12 protein levels (SeqId = 10418-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntaxin-12	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.9	0.221	0.000052	None	Gadd-DA_stx12_protein_levels__seqid___10418-36__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	-0.033378	0.00825197	0.00005262372	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	-0.0333712	0.00825197	0.00005280827	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05698098	chr11:61595494	11	61595494	FADS2	Island	0.0333468	0.00825198	0.00005347889	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNL4B protein levels (SeqId = 15316-262)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNL4B protein levels (SeqId = 15316-262)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin-like protein 4B	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000056	None	Gadd-DA_txnl4b_protein_levels__seqid___15316-262__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FIBP protein levels (SeqId = 19169-88)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FIBP protein levels (SeqId = 19169-88)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acidic fibroblast growth factor intracellular-binding protein	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000056	None	Gadd-DA_fibp_protein_levels__seqid___19169-88__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CHIT1 protein levels (SeqId = 3600-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHIT1 protein levels (SeqId = 3600-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chitotriosidase-1	774	1	Adults (18-65 years)	Both	European	cg14911132	chr11:61596755	11	61596755	FADS2	South shore	-0.82	0.204	0.000057	None	Gadd-DA_chit1_protein_levels__seqid___3600-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPHK1 protein levels (SeqId = 4294-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPHK1 protein levels (SeqId = 4294-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sphingosine kinase 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000057	None	Gadd-DA_sphk1_protein_levels__seqid___4294-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.0338233	0.00840205	0.00005711602	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0331916	0.00825202	0.00005793553	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CASP3 protein levels (SeqId = 3593-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CASP3 protein levels (SeqId = 3593-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Caspase-3	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000058	None	Gadd-DA_casp3_protein_levels__seqid___3593-72__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0384296	0.00956088	0.00005862163	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	G3BP2 protein levels (SeqId = 9831-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	G3BP2 protein levels (SeqId = 9831-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras GTPase-activating protein-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000059	None	Gadd-DA_g3bp2_protein_levels__seqid___9831-12__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.100409	0.0249912	0.00005900539	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	-0.0364487	0.00907703	0.00005961779	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB3D protein levels (SeqId = 19379-154)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB3D protein levels (SeqId = 19379-154)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-3D	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.00006	None	Gadd-DA_rab3d_protein_levels__seqid___19379-154__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EZR protein levels (SeqId = 9753-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EZR protein levels (SeqId = 9753-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ezrin	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.00006	None	Gadd-DA_ezr_protein_levels__seqid___9753-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAK4 protein levels (SeqId = 13719-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAK4 protein levels (SeqId = 13719-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase PAK 4	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.00006	None	Gadd-DA_pak4_protein_levels__seqid___13719-19__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.114052	0.0284223	0.00006025474	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0331149	0.00825204	0.00006026702	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0331007	0.00825205	0.00006070885	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.0330589	0.00825206	0.00006202308	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0330402	0.00825206	0.00006262015	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0330336	0.00825207	0.00006283311	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0330091	0.00825207	0.00006362612	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	0.0717484	0.0179447	0.00006406418	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0329836	0.00825208	0.00006446321	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	0.0329814	0.00825208	0.00006453454	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	-0.0329646	0.00825208	0.00006509317	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMD11 protein levels (SeqId = 13572-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMD11 protein levels (SeqId = 13572-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 26S proteasome non-ATPase regulatory subunit 11	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.22	0.000066	None	Gadd-DA_psmd11_protein_levels__seqid___13572-43__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.149667	0.0375133	0.00006642707	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	MAX protein levels (SeqId = 12411-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAX protein levels (SeqId = 12411-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein max	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.221	0.000067	None	Gadd-DA_max_protein_levels__seqid___12411-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MARK3 protein levels (SeqId = 9747-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MARK3 protein levels (SeqId = 9747-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAP/microtubule affinity-regulating kinase 3	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.89	0.222	0.000067	None	Gadd-DA_mark3_protein_levels__seqid___9747-48__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SCARF1 protein levels (SeqId = 5129-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCARF1 protein levels (SeqId = 5129-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Scavenger receptor class F member 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.222	0.000067	None	Gadd-DA_scarf1_protein_levels__seqid___5129-12__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Breast Cancer (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Breast Cancer (Self-report)	Age, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	10650	1	Adults (18-65y)	Females	European	cg00614641	chr11:61596405	11	61596405	FADS2	Island	-0.058	0.0145	0.000068	None	Robert-F-Hillary_Prevalent_Breast_Cancer_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGFRP3 protein levels (SeqId = 18899-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGFRP3 protein levels (SeqId = 18899-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor-related protein 3	774	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.52	0.131	0.000068	None	Gadd-DA_hdgfrp3_protein_levels__seqid___18899-82__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0328528	0.00825211	0.00006891726	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0463624	0.0116529	0.00006964753	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB32 protein levels (SeqId = 17778-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB32 protein levels (SeqId = 17778-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-32	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.222	0.00007	None	Gadd-DA_rab32_protein_levels__seqid___17778-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	-0.0328142	0.00825213	0.00007028505	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	-0.0328046	0.00825213	0.00007062889	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RPS6KA3 protein levels (SeqId = 3469-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPS6KA3 protein levels (SeqId = 3469-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosomal protein S6 kinase alpha-3	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.221	0.000071	None	Gadd-DA_rps6ka3_protein_levels__seqid___3469-74__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0343334	0.00864341	0.00007154923	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	BNIP3L protein levels (SeqId = 7835-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BNIP3L protein levels (SeqId = 7835-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.222	0.000072	None	Gadd-DA_bnip3l_protein_levels__seqid___7835-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0369915	0.00932027	0.00007254102	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	NAA10 protein levels (SeqId = 17854-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAA10 protein levels (SeqId = 17854-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-alpha-acetyltransferase 10	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.222	0.000073	None	Gadd-DA_naa10_protein_levels__seqid___17854-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0327149	0.00825215	0.00007392786	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05816884	chr11:61595492	11	61595492	FADS2	Island	0.0326816	0.00824456	0.00007404611	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.147719	0.0372719	0.00007422041	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0327009	0.00825216	0.00007445507	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SHC1 protein levels (SeqId = 5272-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHC1 protein levels (SeqId = 5272-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SHC-transforming protein 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.88	0.221	0.000076	None	Gadd-DA_shc1_protein_levels__seqid___5272-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23017530	chr11:61625377	11	61625377	FADS2	Open sea	0.0326572	0.00825217	0.00007612317	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20896974	chr11:61595983	11	61595983	FADS2	Island	-0.0326505	0.00825217	0.00007638139	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	-0.112593	0.0284582	0.00007638408	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.0377861	0.00955341	0.00007681462	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20250926	chr11:61627671	11	61627671	FADS2	Open sea	0.0316427	0.0080003	0.00007683567	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0375775	0.00950151	0.00007692931	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19610905	chr11:61596333	11	61596333	FADS2	Island	0.00022	None	0.000077	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06781209	chr11:61594997	11	61594997	FADS2	Island	0.0326276	0.00825218	0.00007727451	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0326264	0.00825218	0.0000773236	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25324164	chr11:61598330	11	61598330	FADS2	South shore	-0.0417106	0.0105508	0.00007744239	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0815279	0.0206345	0.00007810056	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg02213369	chr11:61608075	11	61608075	FADS2	Open sea	-0.153753	0.0389303	0.00007863147	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.104069	0.0263716	0.00007969946	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	0.0322761	0.00817958	0.00007986016	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	-0.0325579	0.00825219	0.00008005229	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14911132	chr11:61596755	11	61596755	FADS2	South shore	-0.0325512	0.0082522	0.00008032079	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0325348	0.0082522	0.0000809912	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	OPHN1 protein levels (SeqId = 12591-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OPHN1 protein levels (SeqId = 12591-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oligophrenin-1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.22	0.000082	None	Gadd-DA_ophn1_protein_levels__seqid___12591-27__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19481605	chr11:61596812	11	61596812	FADS2	South shore	0.0765572	0.0194348	0.00008206559	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0367024	0.00931913	0.00008240747	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Sharp GC	-	25855720	2015-08-01	Maternal underweight	EFO_0005936	Birth	Additional file 1	DNA methylation	Maternal underweight	Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	601	1	0	Both	European	cg25303599	chr11:61595807	11	61595807	FADS2	Island	0.00999	0.00254	0.0000836	-	25855720_maternal_underweight_birth
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	0.0324684	0.00825222	0.00008375187	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14562930	chr11:61595050	11	61595050	FADS2	Island	-0.0324679	0.00825222	0.0000837752	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	0.0458965	0.0116665	0.00008390968	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CLINT1 protein levels (SeqId = 11659-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLINT1 protein levels (SeqId = 11659-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Clathrin interactor 1	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.221	0.000084	None	Gadd-DA_clint1_protein_levels__seqid___11659-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC5 protein levels (SeqId = 11212-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC5 protein levels (SeqId = 11212-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.874	0.222	0.000084	None	Gadd-DA_txndc5_protein_levels__seqid___11212-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21409469	chr11:61594769	11	61594769	FADS2	North shore	0.0324572	0.00825222	0.0000842253	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21709803	chr11:61594965	11	61594965	FADS2	North shore	-0.0026	0.00065	0.000085	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ADH6 protein levels (SeqId = 18206-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADH6 protein levels (SeqId = 18206-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alcohol dehydrogenase 6	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000085	None	Gadd-DA_adh6_protein_levels__seqid___18206-18__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08093537	chr11:61595225	11	61595225	FADS2	Island	0.0940406	0.0239252	0.00008504552	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.0350463	0.0089188	0.00008551785	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ACYP2 protein levels (SeqId = 12812-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACYP2 protein levels (SeqId = 12812-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acylphosphatase-2	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000088	None	Gadd-DA_acyp2_protein_levels__seqid___12812-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMPO protein levels (SeqId = 8265-225)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMPO protein levels (SeqId = 8265-225)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lamina-associated polypeptide 2, isoforms beta/gamma	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000088	None	Gadd-DA_tmpo_protein_levels__seqid___8265-225__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08281583	chr11:61595223	11	61595223	FADS2	Island	0.0752753	0.019195	0.00008827899	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0366591	0.00935039	0.00008873265	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PNKP protein levels (SeqId = 13657-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNKP protein levels (SeqId = 13657-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bifunctional polynucleotide phosphatase/kinase	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000089	None	Gadd-DA_pnkp_protein_levels__seqid___13657-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TOLLIP protein levels (SeqId = 13963-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TOLLIP protein levels (SeqId = 13963-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Toll-interacting protein	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000089	None	Gadd-DA_tollip_protein_levels__seqid___13963-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NPLOC4 protein levels (SeqId = 12993-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPLOC4 protein levels (SeqId = 12993-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear protein localization protein 4 homolog	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000089	None	Gadd-DA_nploc4_protein_levels__seqid___12993-21__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Kidney Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Kidney Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18000	1	Adults (18-65y)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.016	0.004	0.00009	None	Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	KIT protein levels (SeqId = 2475-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIT protein levels (SeqId = 2475-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mast/stem cell growth factor receptor Kit	774	1	Adults (18-65 years)	Both	European	cg01556593	chr11:61609179	11	61609179	FADS2	Open sea	-0.66	0.168	0.00009	None	Gadd-DA_kit_protein_levels__seqid___2475-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VPS24 protein levels (SeqId = 12508-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VPS24 protein levels (SeqId = 12508-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Charged multivesicular body protein 3	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.00009	None	Gadd-DA_vps24_protein_levels__seqid___12508-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01400685	chr11:61598025	11	61598025	FADS2	South shore	0.0324493	0.00828683	0.00009052422	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19852225	chr11:61621805	11	61621805	FADS2	Open sea	-0.194115	0.0496003	0.0000912881	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	PEX14 protein levels (SeqId = 8300-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PEX14 protein levels (SeqId = 8300-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxisomal membrane protein PEX14	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.87	0.222	0.000092	None	Gadd-DA_pex14_protein_levels__seqid___8300-82__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0372378	0.00952424	0.00009279196	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.034	0.00882	0.000094	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21029357	chr11:61601062	11	61601062	FADS2	Open sea	0.0322288	0.00825228	0.00009447752	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07005513	chr11:61595956	11	61595956	FADS2	Island	-0.0331773	0.00849769	0.00009493206	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA1279 protein levels (SeqId = 12956-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA1279 protein levels (SeqId = 12956-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: KIF1-binding protein	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.86	0.222	0.000095	None	Gadd-DA_kiaa1279_protein_levels__seqid___12956-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00603274	chr11:61596626	11	61596626	FADS2	Island	-0.0322149	0.00825229	0.00009513534	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	VAV1 protein levels (SeqId = 5275-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAV1 protein levels (SeqId = 5275-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proto-oncogene vav	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.86	0.221	0.000096	None	Gadd-DA_vav1_protein_levels__seqid___5275-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDGFD protein levels (SeqId = 17140-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDGFD protein levels (SeqId = 17140-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet-derived growth factor D	774	1	Adults (18-65 years)	Both	European	cg13764085	chr11:61607741	11	61607741	FADS2	Open sea	0.76	0.195	0.000097	None	Gadd-DA_pdgfd_protein_levels__seqid___17140-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB6B protein levels (SeqId = 14271-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB6B protein levels (SeqId = 14271-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-6B	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.86	0.221	0.000097	None	Gadd-DA_rab6b_protein_levels__seqid___14271-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STX4 protein levels (SeqId = 10668-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STX4 protein levels (SeqId = 10668-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntaxin-4	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.86	0.221	0.000097	None	Gadd-DA_stx4_protein_levels__seqid___10668-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13299762	chr11:61594708	11	61594708	FADS2	North shore	-0.0321605	0.0082523	0.00009776085	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	0.0362087	0.00929172	0.00009787565	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDX3 protein levels (SeqId = 8358-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDX3 protein levels (SeqId = 8358-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin-dependent peroxide reductase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg08380661	chr11:61592206	11	61592206	FADS2	North shelf	0.86	0.222	0.000098	None	Gadd-DA_prdx3_protein_levels__seqid___8358-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11250194	chr11:61601937	11	61601937	FADS2	Open sea	-0.0331644	0.00851379	0.00009848349	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3