author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.005 0.00032 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea -0.017 0.0017 0 None 33450751_Mulder-RH_sex_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.53618 0.00665 1.4e-150 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22420756 chr9:19028063 9 19028063 FAM154A Island 0.30083 0.00404 3.6e-144 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea 0.23812 0.00501 1.9e-108 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.29022 0.00619 1.7e-107 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3200648 (gene symbol: PLIN2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3200648 (gene symbol: PLIN2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01403030 chr9:19026479 9 19026479 FAM154A North shore None None 1.4999999999999998e-68 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3200648__gene_symbol__plin2__meta-analysis Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -1.85745 0.09072 5.03e-35 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0844545 0.00822707 1.222002e-24 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0704518 0.00823606 1.304614e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0693249 0.00823671 4.2316050000000005e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22420756 chr9:19028063 9 19028063 FAM154A Island -0.0014 0.00017 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg18043195 chr9:19033231 9 19033231 FAM154A Open sea 0.0074 0.00083 0.000000000000023 None 33564054_Kashima-K_gestational_age Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg22937320 chr9:19032778 9 19032778 FAM154A Open sea 0.0073 0.00087 0.00000000000018 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0585524 0.00824241 0.000000000001269591 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.78777559 0.1166 0.0000000000143 - 25888029_ageing Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13707189 chr9:19028399 9 19028399 FAM154A South shore 0.0024 None 0.000000000087 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0527307 0.00824508 0.0000000001649675 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18043195 chr9:19033231 9 19033231 FAM154A Open sea -0.0079 0.0012 0.00000000019 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg13707189 chr9:19028399 9 19028399 FAM154A South shore -0.03207 0.0053 0.00000000191 - 23334450_rheumatoid_arthritis Xu Z Sister Study 30989176 2019-04-15 breast cancer EFO_0000305 Case vs Control Discovery Supplementary Table 1 DNA methylation breast cancer cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2443 1 Adults Females European cg13707189 chr9:19028399 9 19028399 FAM154A South shore -1.4 0.245 0.000000013 None 30989176_Xu-Z_breast_cancer_case_vs_control_discovery Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg13707189 chr9:19028399 9 19028399 FAM154A South shore -0.00931 0.00165 0.000000016 None 33279932_Li-M_schizophrenia_main Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0453861 0.00824806 0.00000003804332 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg13707189 chr9:19028399 9 19028399 FAM154A South shore None None 0.000000053 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0447392 0.0082483 0.00000005918873 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea - - 0.0000000916 - 26500701_sex_metaanalysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea - - 0.0000000976 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.043859 0.00824863 0.0000001069644 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea -0.0062 0.0012 0.0000003 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0412224 0.00824955 0.0000005892367 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0404562 0.00824981 0.0000009496276 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0401295 0.00824992 0.000001160951 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0466242 0.0096487 0.000001364177 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0039 0.00077 0.0000014 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0394079 0.00825016 0.000001799863 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 T cells Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values Years Illumina HumanMethylation450 T cells - 227 1 - Missing None cg01403030 chr9:19026479 9 19026479 FAM154A North shore - - 0.00000217 - 25404168_age_t_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0388657 0.00825033 0.000002490038 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0386873 0.00825039 0.000002768168 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01403030 chr9:19026479 9 19026479 FAM154A North shore None None 0.0000037 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 2.4 0.51 0.000004 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0375573 0.00825075 0.000005356959 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.036548 0.00825106 0.000009513684 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.00025989 5.85e-05 0.00000996 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22420756 chr9:19028063 9 19028063 FAM154A Island 0.0011 None 0.000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13709720 chr9:19028020 9 19028020 FAM154A Island -0.00077 0.00018 0.000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea 0.0011 None 0.000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.0420007 0.00963812 0.00001322896 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg18043195 chr9:19033231 9 19033231 FAM154A Open sea 0.00031225 7.16e-05 0.0000142 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.1467835 0.0339423 0.00001529 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0355633 0.00825135 0.00001643187 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.131869 0.030659 0.0000170849 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0353751 0.0082514 0.00001821219 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13709720 chr9:19028020 9 19028020 FAM154A Island 0.0011 None 0.00002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.0351295 0.00825148 0.00002081405 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0392981 0.00962343 0.00004458038 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01403030 chr9:19026479 9 19026479 FAM154A North shore None None 0.000046 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01403030 chr9:19026479 9 19026479 FAM154A North shore None None 0.000049 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Battram T ARIES None 2020-08-20 Ratio of triglycerides to phosphoglycerides EFO_0004530, FMA_85433 None None DNA methylation Ratio of triglycerides to phosphoglycerides Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 663 1 Adults Females European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.61 0.151 0.000055 None Battram-T_ratio_of_triglycerides_to_phosphoglycerides Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.033543 0.00833498 0.0000574159 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea 0.00029886 7.41e-05 0.0000593 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.0331227 0.00825204 0.00006002551 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore -0.0330226 0.00825207 0.00006318937 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea 0.0330117 0.00825207 0.00006354374 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18043195 chr9:19033231 9 19033231 FAM154A Open sea -0.0071 0.0018 0.000069 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0309971 0.00780477 0.00007174555 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14553740 chr9:18976715 9 18976715 FAM154A Open sea -0.03277 0.00825214 0.00007188547 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg22937320 chr9:19032778 9 19032778 FAM154A Open sea -0.1022317 0.0258736 0.00007776 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18043195 chr9:19033231 9 19033231 FAM154A Open sea 0.158918 0.0406819 0.0000940505 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0325323 0.00835033 0.0000982555 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01403030 chr9:19026479 9 19026479 FAM154A North shore 0.0023 None 0.000099 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect