author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0025 0.00016 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0062 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.016 0.001 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.15904 0.00294 1.2e-118 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg24058132 chr14:88459866 14 88459866 GALC South shore - - 1.1100000000000001e-100 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13789423 chr14:88455546 14 88455546 GALC North shelf 0.29541 0.00691 2.5e-100 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.160197 0.00814994 6.312961e-85 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.151328 0.00816149 6.98834e-76 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.134681 0.00818135 2.39336e-60 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.132301 0.00818399 2.802697e-58 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.131114 0.00818529 2.912613e-57 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.130605 0.00818585 7.912652e-57 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.128279 0.00818836 7.187043000000001e-55 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.123123 0.00819375 1.173329e-50 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.120724 0.00819618 9.324004e-49 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.114682 0.0082021 3.8512639999999995e-44 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.112243 0.0082044 2.404669e-42 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.109719 0.00820672 1.576455e-40 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.108304 0.008208 1.575389e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.10532 0.00821065 1.835892e-37 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.102295 0.00821326 1.987707e-35 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.100546 0.00821473 2.804163e-34 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0985404 0.00821639 5.5046430000000004e-33 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 Monocytes Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values years Illumina HumanMethylation450 Monocytes - 1264 1 60 Both European,African,Admixed cg24058132 chr14:88459866 14 88459866 GALC South shore - - 6.299999999999999e-31 - 25404168_age_monocytes Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0942595 0.00821981 2.590862e-30 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0896352 0.00822334 1.4685020000000001e-27 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0894471 0.00822348 1.8876390000000002e-27 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0861794 0.00822585 1.361704e-25 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0818852 0.00822884 2.9584e-23 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0813405 0.00822921 5.741644e-23 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0811657 0.00822933 7.095667e-23 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0811257 0.00822936 7.447719000000001e-23 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0804177 0.00822983 1.747674e-22 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0799186 0.00823016 3.174683e-22 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0017 None 5.5e-22 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0785986 0.00823103 1.511715e-21 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0785518 0.00823106 1.596969e-21 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01035038 chr14:88459686 14 88459686 GALC Island -0.01604 0.0015 3e-21 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg07416546 chr14:88460351 14 88460351 GALC South shore -0.031 0.00255 3.2e-21 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.076863 0.00823215 1.131494e-20 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0759113 0.00823275 3.34808e-20 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.04 0.00347 4.9e-20 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0731455 0.00823445 7.26252e-19 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.072066 0.0082351 2.340628e-18 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0719449 0.00823518 2.666185e-18 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0716506 0.00823535 3.655577e-18 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05601096 chr14:88461031 14 88461031 GALC South shore -0.01961 0.00209 1.7e-17 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3575103 (gene symbol: GALC) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3575103 (gene symbol: GALC) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 2.5e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3575103__gene_symbol__galc__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0690709 0.00823685 5.502624e-17 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0689954 0.0082369 5.948254e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0688488 0.00823698 6.917173000000001e-17 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0679821 0.00823747 1.678138e-16 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0674966 0.00823774 2.743773e-16 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0664407 0.00823833 7.89788e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0657454 0.00823871 0.00000000000000157028 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0646766 0.00823928 0.000000000000004454687 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0645529 0.00823935 0.000000000000005020498 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0645146 0.00823937 0.000000000000005209675 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0643651 0.00823945 0.000000000000006017297 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.0641567 0.00823956 0.000000000000007352612 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0639205 0.00823969 0.0000000000000092203 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0638239 0.00823974 0.00000000000001011298 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg07416546 chr14:88460351 14 88460351 GALC South shore -0.011 0.00124 0.000000000000013 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0633659 0.00823998 0.00000000000001563882 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0631697 0.00824008 0.00000000000001883209 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0628741 0.00824024 0.00000000000002489031 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0626792 0.00824034 0.00000000000002989617 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.019 0.00218 0.000000000000037 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0615226 0.00824093 0.00000000000008765108 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0613389 0.00824102 0.0000000000001038028 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -1.11 0.149 0.00000000000013 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.00039 0.000053 0.00000000000014 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0609862 0.0082412 0.000000000000143398 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.060838 0.00824128 0.0000000000001641759 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.041 0.00555 0.0000000000002 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0603613 0.00824152 0.0000000000002531175 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0602481 0.00824157 0.0000000000002803858 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.047 0.00643 0.0000000000003 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.0601002 0.00824165 0.000000000000320402 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.060081 0.00824166 0.0000000000003259693 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0600721 0.00824166 0.0000000000003285983 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0600213 0.00824169 0.0000000000003439923 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0599969 0.0082417 0.0000000000003516128 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0598927 0.00824175 0.0000000000003861131 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0597558 0.00824182 0.0000000000004365648 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea 0.0592748 0.00824205 0.0000000000006706108 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0591828 0.0082421 0.0000000000007276802 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0589071 0.00824223 0.0000000000009289367 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0580853 0.00824263 0.000000000001910558 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0580095 0.00824267 0.000000000002040829 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.258389 0.0367529 0.000000000002131667 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0579484 0.0082427 0.00000000000215232 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0578538 0.00824274 0.000000000002336716 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg05601096 chr14:88461031 14 88461031 GALC South shore -0.02309 0.0033 0.00000000000297 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0573741 0.00824297 0.000000000003537833 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0571494 0.00824308 0.000000000004291623 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -0.0592093 0.00857312 0.000000000005175789 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0566356 0.00824332 0.000000000006656295 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0566144 0.00824333 0.000000000006777271 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.056605 0.00824333 0.000000000006831459 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0564073 0.00824343 0.000000000008079652 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -0.0561603 0.00824354 0.000000000009955546 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.250987 0.0370388 0.00000000001272368 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -1.01 0.15 0.00000000002 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0551026 0.00824403 0.00000000002409984 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -0.0562666 0.00848913 0.00000000003519726 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04052570 chr14:88459528 14 88459528 GALC Island 0.01177 0.00168 0.000000000039 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0542901 0.00824439 0.00000000004700492 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0539907 0.00824453 0.0000000000599852 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0539368 0.00824455 0.00000000006266653 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0534454 0.00824477 0.00000000009320062 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0527569 0.00824507 0.0000000001615673 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0526373 0.00824513 0.0000000001776491 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.052264 0.00824529 0.0000000002385664 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0519886 0.00824541 0.000000000296143 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.051818 0.00824548 0.0000000003384 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0517977 0.00824549 0.0000000003437992 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0517693 0.0082455 0.0000000003514965 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.0517128 0.00824552 0.0000000003673262 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18103730 chr14:88458917 14 88458917 GALC North shore 0.01141 0.00174 0.00000000044 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0513218 0.00824569 0.0000000004975817 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.0512425 0.00824572 0.0000000005290195 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0512185 0.00824573 0.0000000005389201 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0793376 0.0128564 0.0000000006961698 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.050884 0.00824588 0.000000000697112 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05956531 chr14:88407098 14 88407098 GALC Open sea 0.0508606 0.00824589 0.000000000709737 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0581285 0.00942456 0.0000000007107828 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0782578 0.0127499 0.0000000008575285 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0505404 0.00824602 0.0000000009066057 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0505118 0.00824603 0.0000000009265682 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0505106 0.00824603 0.0000000009273776 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20583141 chr14:88461098 14 88461098 GALC South shore -0.02375 0.00369 0.00000000097 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000000012 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0501296 0.00824619 0.000000001238413 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0499647 0.00824626 0.000000001402599 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.031 0.00508 0.0000000015 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.049812 0.00824632 0.000000001573444 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0497861 0.00824633 0.000000001604298 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0497097 0.00824636 0.000000001698991 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg25377313 chr14:88456098 14 88456098 GALC North shelf -0.017 0.00261 0.000000002 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.0494183 0.00824648 0.000000002112881 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0492699 0.00824654 0.000000002359792 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0091 0.0015545 0.0000000024 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.067104 0.0112629 0.000000002612755 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0534833 0.00899507 0.00000000281287 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0529078 0.00901635 0.000000004506247 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0481493 0.008247 0.000000005381517 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08837308 chr14:88459688 14 88459688 GALC Island 0.00031 0.000053 0.0000000054 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.04808 0.00824702 0.000000005659918 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05956531 chr14:88407098 14 88407098 GALC Open sea 0.0480407 0.00824704 0.000000005823872 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.047886 0.0082471 0.000000006515116 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg04052570 chr14:88459528 14 88459528 GALC Island 0.155268 0.0269112 0.000000008071632 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26245531 chr14:88459216 14 88459216 GALC Island -0.000053 0.0000092 0.0000000082 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0475261 0.00824724 0.000000008445959 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0473477 0.00824731 0.000000009598894 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0539045 0.00943697 0.00000001137863 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0488304 0.00855819 0.00000001181144 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0469974 0.00824745 0.00000001232516 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0468911 0.00824749 0.00000001329195 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0468837 0.00824749 0.0000000133618 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 RAD51L3 protein levels (SeqId = 12554-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAD51L3 protein levels (SeqId = 12554-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA repair protein RAD51 homolog 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.78 0.138 0.000000016 None Gadd-DA_rad51l3_protein_levels__seqid___12554-10__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20583141 chr14:88461098 14 88461098 GALC South shore 0.0016 0.00028 0.000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.046385 0.00824768 0.00000001899859 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 1.7 0.302 0.000000019 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.0463252 0.00824771 0.00000001981283 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0462501 0.00824774 0.00000002088355 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0462216 0.00824775 0.00000002130507 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.071493 0.0127623 0.0000000215827 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0460215 0.00824782 0.00000002450091 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg14084312 chr14:88459488 14 88459488 GALC Island 0.00291 0.00053 0.00000003 None 33279932_Li-M_schizophrenia_main Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01822938 chr14:88456162 14 88456162 GALC North shelf 0.203077 0.0368063 0.00000003488547 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0454052 0.00824806 0.00000003754492 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0453344 0.00824808 0.00000003941846 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0451681 0.00824814 0.00000004418169 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0449701 0.00824822 0.00000005058221 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 EGFL6 protein levels (SeqId = 17454-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EGFL6 protein levels (SeqId = 17454-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Epidermal growth factor-like protein 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.75 0.139 0.000000054 None Gadd-DA_egfl6_protein_levels__seqid___17454-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.0446433 0.00824834 0.00000006316151 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0597087 0.0110776 0.00000007153982 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0443977 0.00824843 0.00000007456281 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0442926 0.00824847 0.00000008002506 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0442616 0.00824848 0.00000008171242 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04052570 chr14:88459528 14 88459528 GALC Island 0.0031 0.00059 0.00000011 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0437714 0.00824866 0.0000001133837 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0437659 0.00824866 0.0000001138016 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0437093 0.00824868 0.0000001181584 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FAHD1 protein levels (SeqId = 17819-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAHD1 protein levels (SeqId = 17819-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acylpyruvase FAHD1, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.73 0.139 0.00000012 None Gadd-DA_fahd1_protein_levels__seqid___17819-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0435841 0.00824873 0.0000001283863 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0435018 0.00824876 0.000000135567 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0434915 0.00824876 0.0000001364944 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJB14 protein levels (SeqId = 8053-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJB14 protein levels (SeqId = 8053-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily B member 14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.73 0.139 0.00000014 None Gadd-DA_dnajb14_protein_levels__seqid___8053-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GCDH protein levels (SeqId = 19258-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GCDH protein levels (SeqId = 19258-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaryl-CoA dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.73 0.139 0.00000014 None Gadd-DA_gcdh_protein_levels__seqid___19258-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0433764 0.0082488 0.0000001472659 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.104028 0.0198677 0.0000001663155 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0662008 0.0126478 0.0000001680253 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 TOR1AIP1 protein levels (SeqId = 10606-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TOR1AIP1 protein levels (SeqId = 10606-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Torsin-1A-interacting protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.73 0.139 0.00000017 None Gadd-DA_tor1aip1_protein_levels__seqid___10606-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACSF2 protein levels (SeqId = 17466-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACSF2 protein levels (SeqId = 17466-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acyl-CoA synthetase family member 2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.72 0.139 0.00000018 None Gadd-DA_acsf2_protein_levels__seqid___17466-72__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0672306 0.0129231 0.0000001994177 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0675227 0.0129793 0.0000001994519 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.037 0.00721 0.00000024 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0463688 0.00898948 0.0000002526934 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PGM2 protein levels (SeqId = 18330-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PGM2 protein levels (SeqId = 18330-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoglucomutase-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.71 0.138 0.00000026 None Gadd-DA_pgm2_protein_levels__seqid___18330-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTK2B protein levels (SeqId = 8918-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTK2B protein levels (SeqId = 8918-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein-tyrosine kinase 2-beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.72 0.139 0.00000027 None Gadd-DA_ptk2b_protein_levels__seqid___8918-64__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0424335 0.00824913 0.0000002724321 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LEMD1 protein levels (SeqId = 8040-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LEMD1 protein levels (SeqId = 8040-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: LEM domain-containing protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.714 0.139 0.00000028 None Gadd-DA_lemd1_protein_levels__seqid___8040-9__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.214006 0.0416654 0.0000002832561 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.0423215 0.00824917 0.000000292821 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0423184 0.00824918 0.0000002934092 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14084312 chr14:88459488 14 88459488 GALC Island 0.141652 0.0276345 0.0000002991555 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.042235 0.0082492 0.0000003095914 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg14084312 chr14:88459488 14 88459488 GALC Island None None 0.00000032 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0421362 0.00824924 0.0000003298723 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PRDX3 protein levels (SeqId = 8358-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRDX3 protein levels (SeqId = 8358-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin-dependent peroxide reductase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.71 0.139 0.00000034 None Gadd-DA_prdx3_protein_levels__seqid___8358-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0420659 0.00824926 0.0000003450537 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14084312 chr14:88459488 14 88459488 GALC Island 0.00038 0.000074 0.00000035 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0419805 0.00824929 0.0000003644423 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PDHX protein levels (SeqId = 18319-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDHX protein levels (SeqId = 18319-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyruvate dehydrogenase protein X component, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.71 0.139 0.00000037 None Gadd-DA_pdhx_protein_levels__seqid___18319-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRPEL1 protein levels (SeqId = 7113-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRPEL1 protein levels (SeqId = 7113-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GrpE protein homolog 1, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.71 0.139 0.00000038 None Gadd-DA_grpel1_protein_levels__seqid___7113-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ASNA1 protein levels (SeqId = 13620-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASNA1 protein levels (SeqId = 13620-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATPase ASNA1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.71 0.139 0.00000039 None Gadd-DA_asna1_protein_levels__seqid___13620-10__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.187864 0.0370315 0.0000003954573 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ABHD10 protein levels (SeqId = 17370-186) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ABHD10 protein levels (SeqId = 17370-186) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mycophenolic acid acyl-glucuronide esterase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.7 0.139 0.0000004 None Gadd-DA_abhd10_protein_levels__seqid___17370-186__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.160941 0.0318938 0.0000004551208 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 TACO1 protein levels (SeqId = 9257-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TACO1 protein levels (SeqId = 9257-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Translational activator of cytochrome c oxidase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.7 0.139 0.00000046 None Gadd-DA_taco1_protein_levels__seqid___9257-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIAA0040 protein levels (SeqId = 14603-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA0040 protein levels (SeqId = 14603-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein KIAA0040 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.7 0.139 0.00000047 None Gadd-DA_kiaa0040_protein_levels__seqid___14603-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GATM protein levels (SeqId = 18188-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GATM protein levels (SeqId = 18188-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycine amidinotransferase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.7 0.139 0.0000005 None Gadd-DA_gatm_protein_levels__seqid___18188-12__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18103730 chr14:88458917 14 88458917 GALC North shore 0.0016 None 0.0000005 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 UFM1 protein levels (SeqId = 3836-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UFM1 protein levels (SeqId = 3836-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-fold modifier 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.7 0.139 0.00000051 None Gadd-DA_ufm1_protein_levels__seqid___3836-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0414342 0.00824948 0.0000005156243 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0413897 0.0082495 0.0000005303391 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.0451898 0.00901854 0.0000005484475 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0412588 0.00823607 0.0000005519866 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0413121 0.00824952 0.0000005568916 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000006 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.179385 0.0360298 0.000000645685 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 PTP4A2 protein levels (SeqId = 11699-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTP4A2 protein levels (SeqId = 11699-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein tyrosine phosphatase type IVA 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.139 0.00000067 None Gadd-DA_ptp4a2_protein_levels__seqid___11699-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NIP7 protein levels (SeqId = 12564-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NIP7 protein levels (SeqId = 12564-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 60S ribosome subunit biogenesis protein NIP7 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.139 0.00000073 None Gadd-DA_nip7_protein_levels__seqid___12564-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRAT protein levels (SeqId = 12637-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRAT protein levels (SeqId = 12637-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carnitine O-acetyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.138 0.00000073 None Gadd-DA_crat_protein_levels__seqid___12637-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CASS4 protein levels (SeqId = 12855-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CASS4 protein levels (SeqId = 12855-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cas scaffolding protein family member 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.139 0.00000076 None Gadd-DA_cass4_protein_levels__seqid___12855-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HINT2 protein levels (SeqId = 5612-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HINT2 protein levels (SeqId = 5612-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histidine triad nucleotide-binding protein 2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.139 0.00000078 None Gadd-DA_hint2_protein_levels__seqid___5612-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BID protein levels (SeqId = 5798-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BID protein levels (SeqId = 5798-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BH3-interacting domain death agonist 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.69 0.139 0.0000008 None Gadd-DA_bid_protein_levels__seqid___5798-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0444305 0.00900781 0.0000008209848 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 MTIF3 protein levels (SeqId = 7852-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTIF3 protein levels (SeqId = 7852-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Translation initiation factor IF-3, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.00000085 None Gadd-DA_mtif3_protein_levels__seqid___7852-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HEXIM1 protein levels (SeqId = 15596-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HEXIM1 protein levels (SeqId = 15596-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein HEXIM1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.138 0.00000085 None Gadd-DA_hexim1_protein_levels__seqid___15596-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0406235 0.00824976 0.0000008562456 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18103730 chr14:88458917 14 88458917 GALC North shore 0.00047 None 0.00000086 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 DDOST protein levels (SeqId = 17161-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DDOST protein levels (SeqId = 17161-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.00000087 None Gadd-DA_ddost_protein_levels__seqid___17161-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0405432 0.00824978 0.0000008998815 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0404649 0.00824981 0.0000009445004 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0557331 0.0113708 0.0000009616136 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 NSFL1C protein levels (SeqId = 4250-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NSFL1C protein levels (SeqId = 4250-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NSFL1 cofactor p47 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.677 0.138 0.00000097 None Gadd-DA_nsfl1c_protein_levels__seqid___4250-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DRG1 protein levels (SeqId = 17849-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DRG1 protein levels (SeqId = 17849-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Developmentally-regulated GTP-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.000001 None Gadd-DA_drg1_protein_levels__seqid___17849-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPCPD1 protein levels (SeqId = 12786-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPCPD1 protein levels (SeqId = 12786-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycerophosphocholine phosphodiesterase GPCPD1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.000001 None Gadd-DA_gpcpd1_protein_levels__seqid___12786-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMEM106A protein levels (SeqId = 10499-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM106A protein levels (SeqId = 10499-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein 106A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.138 0.0000011 None Gadd-DA_tmem106a_protein_levels__seqid___10499-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF4H protein levels (SeqId = 5885-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF4H protein levels (SeqId = 5885-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 4H 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.0000011 None Gadd-DA_eif4h_protein_levels__seqid___5885-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IDI1 protein levels (SeqId = 17712-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IDI1 protein levels (SeqId = 17712-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Isopentenyl-diphosphate Delta-isomerase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.0000011 None Gadd-DA_idi1_protein_levels__seqid___17712-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KPNB1 protein levels (SeqId = 3887-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KPNB1 protein levels (SeqId = 3887-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Importin subunit beta-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.0000011 None Gadd-DA_kpnb1_protein_levels__seqid___3887-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPE protein levels (SeqId = 12646-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPE protein levels (SeqId = 12646-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribulose-phosphate 3-epimerase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.0000011 None Gadd-DA_rpe_protein_levels__seqid___12646-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore 0.040161 0.00824991 0.000001138743 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJB11 protein levels (SeqId = 7110-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJB11 protein levels (SeqId = 7110-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily B member 11 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.68 0.139 0.0000012 None Gadd-DA_dnajb11_protein_levels__seqid___7110-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0549149 0.0113217 0.000001244817 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0399994 0.00824996 0.00000125714 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADH6 protein levels (SeqId = 18206-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH6 protein levels (SeqId = 18206-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000013 None Gadd-DA_adh6_protein_levels__seqid___18206-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DLX4 protein levels (SeqId = 11910-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DLX4 protein levels (SeqId = 11910-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homeobox protein DLX-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000013 None Gadd-DA_dlx4_protein_levels__seqid___11910-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0399236 0.00824999 0.000001316711 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg24058132 chr14:88459866 14 88459866 GALC South shore - - 0.00000138 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.044141 0.00914171 0.00000138934 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 DTYMK protein levels (SeqId = 19504-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DTYMK protein levels (SeqId = 19504-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thymidylate kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000014 None Gadd-DA_dtymk_protein_levels__seqid___19504-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RTN4IP1 protein levels (SeqId = 18180-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RTN4IP1 protein levels (SeqId = 18180-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Reticulon-4-interacting protein 1, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000014 None Gadd-DA_rtn4ip1_protein_levels__seqid___18180-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2G1 protein levels (SeqId = 17158-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2G1 protein levels (SeqId = 17158-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 G1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000014 None Gadd-DA_ube2g1_protein_levels__seqid___17158-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDT16L1 protein levels (SeqId = 12497-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDT16L1 protein levels (SeqId = 12497-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tudor-interacting repair regulator protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000014 None Gadd-DA_nudt16l1_protein_levels__seqid___12497-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0398146 0.00825002 0.000001407085 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.179175 0.0371479 0.00000142413 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0397278 0.00825005 0.000001483268 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FAM162A protein levels (SeqId = 6531-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM162A protein levels (SeqId = 6531-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein FAM162A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000015 None Gadd-DA_fam162a_protein_levels__seqid___6531-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYL12B protein levels (SeqId = 19122-47) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYL12B protein levels (SeqId = 19122-47) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myosin regulatory light chain 12B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000015 None Gadd-DA_myl12b_protein_levels__seqid___19122-47__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.054 0.01131 0.0000015 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0443392 0.00922578 0.000001554979 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 LMAN2L protein levels (SeqId = 8013-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LMAN2L protein levels (SeqId = 8013-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: VIP36-like protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000016 None Gadd-DA_lman2l_protein_levels__seqid___8013-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PANK3 protein levels (SeqId = 12658-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PANK3 protein levels (SeqId = 12658-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pantothenate kinase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000016 None Gadd-DA_pank3_protein_levels__seqid___12658-72__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC10 protein levels (SeqId = 8297-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC10 protein levels (SeqId = 8297-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 10 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.67 0.139 0.0000016 None Gadd-DA_dnajc10_protein_levels__seqid___8297-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMAP1 protein levels (SeqId = 11649-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMAP1 protein levels (SeqId = 11649-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stromal membrane-associated protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.138 0.0000016 None Gadd-DA_smap1_protein_levels__seqid___11649-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DKK4 protein levels (SeqId = 3365-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DKK4 protein levels (SeqId = 3365-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dickkopf-related protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000017 None Gadd-DA_dkk4_protein_levels__seqid___3365-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B4GALT7 protein levels (SeqId = 7806-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B4GALT7 protein levels (SeqId = 7806-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,4-galactosyltransferase 7 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000018 None Gadd-DA_b4galt7_protein_levels__seqid___7806-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPHK1 protein levels (SeqId = 4294-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPHK1 protein levels (SeqId = 4294-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sphingosine kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000018 None Gadd-DA_sphk1_protein_levels__seqid___4294-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NACA protein levels (SeqId = 3854-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NACA protein levels (SeqId = 3854-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nascent polypeptide-associated complex subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.138 0.0000019 None Gadd-DA_naca_protein_levels__seqid___3854-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIP4K2A protein levels (SeqId = 12697-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIP4K2A protein levels (SeqId = 12697-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000019 None Gadd-DA_pip4k2a_protein_levels__seqid___12697-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LCK protein levels (SeqId = 4560-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LCK protein levels (SeqId = 4560-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tyrosine-protein kinase Lck 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000019 None Gadd-DA_lck_protein_levels__seqid___4560-34__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0392904 0.0082502 0.000001931742 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0392474 0.00825021 0.000001982193 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CPXM1 protein levels (SeqId = 6255-74) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPXM1 protein levels (SeqId = 6255-74) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable carboxypeptidase X1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_cpxm1_protein_levels__seqid___6255-74__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KPNA6 protein levels (SeqId = 13969-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KPNA6 protein levels (SeqId = 13969-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Importin subunit alpha-7 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_kpna6_protein_levels__seqid___13969-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CA13 protein levels (SeqId = 3420-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CA13 protein levels (SeqId = 3420-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carbonic anhydrase 13 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_ca13_protein_levels__seqid___3420-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAT3 protein levels (SeqId = 10346-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAT3 protein levels (SeqId = 10346-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal transducer and activator of transcription 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_stat3_protein_levels__seqid___10346-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDE5A protein levels (SeqId = 5256-86) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDE5A protein levels (SeqId = 5256-86) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: cGMP-specific 3',5'-cyclic phosphodiesterase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_pde5a_protein_levels__seqid___5256-86__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKACA protein levels (SeqId = 3466-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKACA protein levels (SeqId = 3466-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: cAMP-dependent protein kinase catalytic subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.000002 None Gadd-DA_prkaca_protein_levels__seqid___3466-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0391739 0.00825023 0.000002071525 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJB1 protein levels (SeqId = 3852-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJB1 protein levels (SeqId = 3852-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily B member 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000021 None Gadd-DA_dnajb1_protein_levels__seqid___3852-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IDH3G protein levels (SeqId = 19275-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IDH3G protein levels (SeqId = 19275-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000021 None Gadd-DA_idh3g_protein_levels__seqid___19275-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DEF6 protein levels (SeqId = 14090-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEF6 protein levels (SeqId = 14090-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Differentially expressed in FDCP 6 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000021 None Gadd-DA_def6_protein_levels__seqid___14090-23__somascan_protein_measurement Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 T cells Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values Years Illumina HumanMethylation450 T cells - 227 1 - Missing None cg24058132 chr14:88459866 14 88459866 GALC South shore - - 0.0000021 - 25404168_age_t_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0615541 0.0129852 0.000002153721 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 FKBP6 protein levels (SeqId = 12529-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FKBP6 protein levels (SeqId = 12529-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000022 None Gadd-DA_fkbp6_protein_levels__seqid___12529-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL15 protein levels (SeqId = 19568-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL15 protein levels (SeqId = 19568-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-15 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000022 None Gadd-DA_il15_protein_levels__seqid___19568-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSMD4 protein levels (SeqId = 13568-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMD4 protein levels (SeqId = 13568-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 26S proteasome non-ATPase regulatory subunit 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000022 None Gadd-DA_psmd4_protein_levels__seqid___13568-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24457814 chr14:88454549 14 88454549 GALC Open sea -0.0390723 0.00825027 0.000002201493 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0390247 0.00825028 0.000002264962 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 APLP2 protein levels (SeqId = 10627-87) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APLP2 protein levels (SeqId = 10627-87) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Amyloid-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.138 0.0000023 None Gadd-DA_aplp2_protein_levels__seqid___10627-87__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPG21 protein levels (SeqId = 11122-97) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPG21 protein levels (SeqId = 11122-97) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Maspardin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000023 None Gadd-DA_spg21_protein_levels__seqid___11122-97__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSD17B10 protein levels (SeqId = 4217-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSD17B10 protein levels (SeqId = 4217-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-hydroxyacyl-CoA dehydrogenase type-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000023 None Gadd-DA_hsd17b10_protein_levels__seqid___4217-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ASMTL protein levels (SeqId = 10089-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASMTL protein levels (SeqId = 10089-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000023 None Gadd-DA_asmtl_protein_levels__seqid___10089-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0389928 0.00825029 0.000002308517 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0665366 0.014081 0.000002319519 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea 0.0389368 0.00825031 0.000002386884 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC19 protein levels (SeqId = 4545-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC19 protein levels (SeqId = 4545-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitochondrial import inner membrane translocase subunit TIM14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000024 None Gadd-DA_dnajc19_protein_levels__seqid___4545-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPS6KA3 protein levels (SeqId = 3469-74) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS6KA3 protein levels (SeqId = 3469-74) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribosomal protein S6 kinase alpha-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.138 0.0000024 None Gadd-DA_rps6ka3_protein_levels__seqid___3469-74__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FKBP14 protein levels (SeqId = 9340-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FKBP14 protein levels (SeqId = 9340-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.66 0.139 0.0000024 None Gadd-DA_fkbp14_protein_levels__seqid___9340-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACADVL protein levels (SeqId = 19262-219) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACADVL protein levels (SeqId = 19262-219) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000024 None Gadd-DA_acadvl_protein_levels__seqid___19262-219__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.00051 0.00011 0.0000025 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 SARS2 protein levels (SeqId = 12348-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SARS2 protein levels (SeqId = 12348-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine--tRNA ligase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000025 None Gadd-DA_sars2_protein_levels__seqid___12348-46__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TBCE protein levels (SeqId = 11211-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TBCE protein levels (SeqId = 11211-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tubulin-specific chaperone E 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.138 0.0000025 None Gadd-DA_tbce_protein_levels__seqid___11211-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCDC50 protein levels (SeqId = 12399-194) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCDC50 protein levels (SeqId = 12399-194) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coiled-coil domain-containing protein 50 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.654 0.139 0.0000025 None Gadd-DA_ccdc50_protein_levels__seqid___12399-194__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HIBCH protein levels (SeqId = 12396-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HIBCH protein levels (SeqId = 12396-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000026 None Gadd-DA_hibch_protein_levels__seqid___12396-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANXA6 protein levels (SeqId = 5335-73) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANXA6 protein levels (SeqId = 5335-73) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Annexin A6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000026 None Gadd-DA_anxa6_protein_levels__seqid___5335-73__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPCS protein levels (SeqId = 17843-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPCS protein levels (SeqId = 17843-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphopantothenate--cysteine ligase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000027 None Gadd-DA_ppcs_protein_levels__seqid___17843-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NIT2 protein levels (SeqId = 17808-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NIT2 protein levels (SeqId = 17808-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Omega-amidase NIT2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000027 None Gadd-DA_nit2_protein_levels__seqid___17808-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMPO protein levels (SeqId = 8265-225) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPO protein levels (SeqId = 8265-225) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lamina-associated polypeptide 2, isoforms beta/gamma 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000027 None Gadd-DA_tmpo_protein_levels__seqid___8265-225__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea 0.0387201 0.00825038 0.000002714884 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FAM150B protein levels (SeqId = 6284-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM150B protein levels (SeqId = 6284-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ALK and LTK ligand 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000028 None Gadd-DA_fam150b_protein_levels__seqid___6284-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IFIT3 protein levels (SeqId = 13642-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFIT3 protein levels (SeqId = 13642-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon-induced protein with tetratricopeptide repeats 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.138 0.0000028 None Gadd-DA_ifit3_protein_levels__seqid___13642-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TFAM protein levels (SeqId = 9952-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TFAM protein levels (SeqId = 9952-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription factor A, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000028 None Gadd-DA_tfam_protein_levels__seqid___9952-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PA2G4 protein levels (SeqId = 4258-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PA2G4 protein levels (SeqId = 4258-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proliferation-associated protein 2G4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000028 None Gadd-DA_pa2g4_protein_levels__seqid___4258-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GMPR2 protein levels (SeqId = 19446-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GMPR2 protein levels (SeqId = 19446-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GMP reductase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000029 None Gadd-DA_gmpr2_protein_levels__seqid___19446-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C11orf68 protein levels (SeqId = 8307-47) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C11orf68 protein levels (SeqId = 8307-47) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UPF0696 protein C11orf68 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000029 None Gadd-DA_c11orf68_protein_levels__seqid___8307-47__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PAK4 protein levels (SeqId = 13719-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAK4 protein levels (SeqId = 13719-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase PAK 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000029 None Gadd-DA_pak4_protein_levels__seqid___13719-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAP2K1 protein levels (SeqId = 2864-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAP2K1 protein levels (SeqId = 2864-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000029 None Gadd-DA_map2k1_protein_levels__seqid___2864-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRB10 protein levels (SeqId = 11358-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRB10 protein levels (SeqId = 11358-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth factor receptor-bound protein 10 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.138 0.0000029 None Gadd-DA_grb10_protein_levels__seqid___11358-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05956531 chr14:88407098 14 88407098 GALC Open sea -0.0385526 0.00825043 0.000002997724 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 UBLCP1 protein levels (SeqId = 19124-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBLCP1 protein levels (SeqId = 19124-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-like domain-containing CTD phosphatase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.000003 None Gadd-DA_ublcp1_protein_levels__seqid___19124-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NFE2L1 protein levels (SeqId = 11154-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NFE2L1 protein levels (SeqId = 11154-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endoplasmic reticulum membrane sensor NFE2L1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.000003 None Gadd-DA_nfe2l1_protein_levels__seqid___11154-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDE11A protein levels (SeqId = 5252-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDE11A protein levels (SeqId = 5252-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.000003 None Gadd-DA_pde11a_protein_levels__seqid___5252-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PEX14 protein levels (SeqId = 8300-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PEX14 protein levels (SeqId = 8300-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxisomal membrane protein PEX14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.000003 None Gadd-DA_pex14_protein_levels__seqid___8300-82__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBL4A protein levels (SeqId = 11490-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBL4A protein levels (SeqId = 11490-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-like protein 4A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.138 0.000003 None Gadd-DA_ubl4a_protein_levels__seqid___11490-42__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DUT protein levels (SeqId = 9995-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DUT protein levels (SeqId = 9995-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000031 None Gadd-DA_dut_protein_levels__seqid___9995-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea -0.0384877 0.00825045 0.000003114658 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0384815 0.00825046 0.000003125979 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AGFG1 protein levels (SeqId = 11681-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGFG1 protein levels (SeqId = 11681-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Arf-GAP domain and FG repeat-containing protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000032 None Gadd-DA_agfg1_protein_levels__seqid___11681-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PGK1 protein levels (SeqId = 5020-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PGK1 protein levels (SeqId = 5020-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoglycerate kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000032 None Gadd-DA_pgk1_protein_levels__seqid___5020-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HRAS protein levels (SeqId = 18900-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HRAS protein levels (SeqId = 18900-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GTPase HRas 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000032 None Gadd-DA_hras_protein_levels__seqid___18900-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACAT2 protein levels (SeqId = 17341-89) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACAT2 protein levels (SeqId = 17341-89) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acetyl-CoA acetyltransferase, cytosolic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.138 0.0000032 None Gadd-DA_acat2_protein_levels__seqid___17341-89__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0383991 0.00825048 0.000003281481 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AHCYL1 protein levels (SeqId = 12652-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AHCYL1 protein levels (SeqId = 12652-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: S-adenosylhomocysteine hydrolase-like protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000033 None Gadd-DA_ahcyl1_protein_levels__seqid___12652-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDC protein levels (SeqId = 8887-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDC protein levels (SeqId = 8887-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear migration protein nudC 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000033 None Gadd-DA_nudc_protein_levels__seqid___8887-21__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0437862 0.00942252 0.000003397669 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Cardenas A Project Viva 31300640 Jul 12, 2019 fractional exhaled nitric oxide (FeNO) EFO_0005536 None Supplementary Data 2 DNA methylation fractional exhaled nitric oxide (FeNO) Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values ppb Illumina HumanMethylationEPIC nasal epithelium None 517 1 Children Both Other cg04738877 chr14:88459963 14 88459963 GALC South shore -2.25 0.48 0.0000035 SE manually calculated 31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_ Gadd DA Generation Scotland 35945220 31/07/2022 HSPE1 protein levels (SeqId = 17150-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPE1 protein levels (SeqId = 17150-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 10 kDa heat shock protein, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000035 None Gadd-DA_hspe1_protein_levels__seqid___17150-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPI protein levels (SeqId = 4272-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPI protein levels (SeqId = 4272-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glucose-6-phosphate isomerase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.65 0.139 0.0000035 None Gadd-DA_gpi_protein_levels__seqid___4272-46__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPK10 protein levels (SeqId = 15418-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPK10 protein levels (SeqId = 15418-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitogen-activated protein kinase 10 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000035 None Gadd-DA_mapk10_protein_levels__seqid___15418-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SHC1 protein levels (SeqId = 16043-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SHC1 protein levels (SeqId = 16043-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SHC-transforming protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000035 None Gadd-DA_shc1_protein_levels__seqid___16043-30__somascan_protein_measurement Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000035 None 31789449_Dugue-P-A_alcohol_consumption_replication Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.037 0.00804 0.0000035 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0382878 0.00825052 0.000003503223 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PIN4 protein levels (SeqId = 12718-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIN4 protein levels (SeqId = 12718-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000036 None Gadd-DA_pin4_protein_levels__seqid___12718-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAFG protein levels (SeqId = 19281-86) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAFG protein levels (SeqId = 19281-86) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription factor MafG 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000036 None Gadd-DA_mafg_protein_levels__seqid___19281-86__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MESDC2 protein levels (SeqId = 15299-102) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MESDC2 protein levels (SeqId = 15299-102) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: LRP chaperone MESD 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000036 None Gadd-DA_mesdc2_protein_levels__seqid___15299-102__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0381982 0.00825055 0.000003692065 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TMX3 protein levels (SeqId = 5654-70) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMX3 protein levels (SeqId = 5654-70) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase TMX3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.645 0.139 0.0000037 None Gadd-DA_tmx3_protein_levels__seqid___5654-70__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PMVK protein levels (SeqId = 12450-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PMVK protein levels (SeqId = 12450-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphomevalonate kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.644 0.139 0.0000037 None Gadd-DA_pmvk_protein_levels__seqid___12450-42__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NMT1 protein levels (SeqId = 5196-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NMT1 protein levels (SeqId = 5196-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycylpeptide N-tetradecanoyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000037 None Gadd-DA_nmt1_protein_levels__seqid___5196-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 G3BP2 protein levels (SeqId = 9831-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 G3BP2 protein levels (SeqId = 9831-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras GTPase-activating protein-binding protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_g3bp2_protein_levels__seqid___9831-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CAB39 protein levels (SeqId = 17757-86) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CAB39 protein levels (SeqId = 17757-86) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcium-binding protein 39 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_cab39_protein_levels__seqid___17757-86__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPBP protein levels (SeqId = 16765-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPBP protein levels (SeqId = 16765-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet basic protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_ppbp_protein_levels__seqid___16765-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FXR1 protein levels (SeqId = 13076-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FXR1 protein levels (SeqId = 13076-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fragile X mental retardation syndrome-related protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_fxr1_protein_levels__seqid___13076-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB32 protein levels (SeqId = 17778-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB32 protein levels (SeqId = 17778-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-32 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_rab32_protein_levels__seqid___17778-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VTA1 protein levels (SeqId = 4209-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VTA1 protein levels (SeqId = 4209-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vacuolar protein sorting-associated protein VTA1 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000038 None Gadd-DA_vta1_protein_levels__seqid___4209-60__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0381244 0.00825057 0.0000038547 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0381207 0.00825057 0.000003863036 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg08837308 chr14:88459688 14 88459688 GALC Island 0.158057 0.0342129 0.000003867006 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 GABARAPL2 protein levels (SeqId = 12494-99) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GABARAPL2 protein levels (SeqId = 12494-99) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gamma-aminobutyric acid receptor-associated protein-like 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000039 None Gadd-DA_gabarapl2_protein_levels__seqid___12494-99__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CARS protein levels (SeqId = 14098-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CARS protein levels (SeqId = 14098-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cysteine--tRNA ligase, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000039 None Gadd-DA_cars_protein_levels__seqid___14098-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PABPN1 protein levels (SeqId = 8921-139) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PABPN1 protein levels (SeqId = 8921-139) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyadenylate-binding protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000039 None Gadd-DA_pabpn1_protein_levels__seqid___8921-139__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIN1 protein levels (SeqId = 15474-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIN1 protein levels (SeqId = 15474-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000039 None Gadd-DA_pin1_protein_levels__seqid___15474-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.87 0.188 0.0000039 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UNC45A protein levels (SeqId = 13082-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UNC45A protein levels (SeqId = 13082-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein unc-45 homolog A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.000004 None Gadd-DA_unc45a_protein_levels__seqid___13082-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKCI protein levels (SeqId = 3379-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKCI protein levels (SeqId = 3379-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein kinase C iota type 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.000004 None Gadd-DA_prkci_protein_levels__seqid___3379-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ISOC1 protein levels (SeqId = 9816-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ISOC1 protein levels (SeqId = 9816-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Isochorismatase domain-containing protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.000004 None Gadd-DA_isoc1_protein_levels__seqid___9816-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CACNB4 protein levels (SeqId = 11130-158) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CACNB4 protein levels (SeqId = 11130-158) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Voltage-dependent L-type calcium channel subunit beta-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000041 None Gadd-DA_cacnb4_protein_levels__seqid___11130-158__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF4G2 protein levels (SeqId = 4230-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF4G2 protein levels (SeqId = 4230-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 4 gamma 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000041 None Gadd-DA_eif4g2_protein_levels__seqid___4230-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTGES2 protein levels (SeqId = 18458-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTGES2 protein levels (SeqId = 18458-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prostaglandin E synthase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000041 None Gadd-DA_ptges2_protein_levels__seqid___18458-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TREML1 protein levels (SeqId = 9329-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TREML1 protein levels (SeqId = 9329-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trem-like transcript 1 protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.138 0.0000041 None Gadd-DA_treml1_protein_levels__seqid___9329-28__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0379872 0.00825061 0.000004175918 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.98 0.213 0.0000042 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BOLA3 protein levels (SeqId = 5980-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BOLA3 protein levels (SeqId = 5980-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BolA-like protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000042 None Gadd-DA_bola3_protein_levels__seqid___5980-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNPNAT1 protein levels (SeqId = 13954-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNPNAT1 protein levels (SeqId = 13954-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glucosamine 6-phosphate N-acetyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000042 None Gadd-DA_gnpnat1_protein_levels__seqid___13954-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 USO1 protein levels (SeqId = 13639-101) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 USO1 protein levels (SeqId = 13639-101) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: General vesicular transport factor p115 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000042 None Gadd-DA_uso1_protein_levels__seqid___13639-101__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLC30A5 protein levels (SeqId = 9594-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLC30A5 protein levels (SeqId = 9594-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc transporter 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.138 0.0000042 None Gadd-DA_slc30a5_protein_levels__seqid___9594-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNX4 protein levels (SeqId = 3903-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNX4 protein levels (SeqId = 3903-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sorting nexin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000042 None Gadd-DA_snx4_protein_levels__seqid___3903-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAD23B protein levels (SeqId = 12522-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAD23B protein levels (SeqId = 12522-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UV excision repair protein RAD23 homolog B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000043 None Gadd-DA_rad23b_protein_levels__seqid___12522-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDCD3 protein levels (SeqId = 4254-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDCD3 protein levels (SeqId = 4254-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NudC domain-containing protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000043 None Gadd-DA_nudcd3_protein_levels__seqid___4254-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNAJB4 protein levels (SeqId = 18884-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJB4 protein levels (SeqId = 18884-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily B member 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000044 None Gadd-DA_dnajb4_protein_levels__seqid___18884-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACOT13 protein levels (SeqId = 17675-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACOT13 protein levels (SeqId = 17675-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acyl-coenzyme A thioesterase 13 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000045 None Gadd-DA_acot13_protein_levels__seqid___17675-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH6A1 protein levels (SeqId = 19136-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH6A1 protein levels (SeqId = 19136-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000045 None Gadd-DA_aldh6a1_protein_levels__seqid___19136-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COX5A protein levels (SeqId = 18226-148) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COX5A protein levels (SeqId = 18226-148) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytochrome c oxidase subunit 5A, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000045 None Gadd-DA_cox5a_protein_levels__seqid___18226-148__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GSTK1 protein levels (SeqId = 13474-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSTK1 protein levels (SeqId = 13474-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione S-transferase kappa 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000045 None Gadd-DA_gstk1_protein_levels__seqid___13474-40__somascan_protein_measurement Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0026 0.00054 0.0000046 None 33564054_Kashima-K_gestational_age Gadd DA Generation Scotland 35945220 31/07/2022 PDCD6IP protein levels (SeqId = 18174-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDCD6IP protein levels (SeqId = 18174-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Programmed cell death 6-interacting protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000046 None Gadd-DA_pdcd6ip_protein_levels__seqid___18174-79__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0378039 0.00825067 0.000004645264 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LRPAP1 protein levels (SeqId = 3640-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRPAP1 protein levels (SeqId = 3640-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-2-macroglobulin receptor-associated protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000047 None Gadd-DA_lrpap1_protein_levels__seqid___3640-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APOBEC3G protein levels (SeqId = 13930-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOBEC3G protein levels (SeqId = 13930-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA dC->dU-editing enzyme APOBEC-3G 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000047 None Gadd-DA_apobec3g_protein_levels__seqid___13930-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RANBP1 protein levels (SeqId = 18191-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RANBP1 protein levels (SeqId = 18191-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ran-specific GTPase-activating protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000047 None Gadd-DA_ranbp1_protein_levels__seqid___18191-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DPY30 protein levels (SeqId = 13943-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DPY30 protein levels (SeqId = 13943-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein dpy-30 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000047 None Gadd-DA_dpy30_protein_levels__seqid___13943-38__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UFC1 protein levels (SeqId = 3405-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UFC1 protein levels (SeqId = 3405-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-fold modifier-conjugating enzyme 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000047 None Gadd-DA_ufc1_protein_levels__seqid___3405-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SHMT2 protein levels (SeqId = 12691-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SHMT2 protein levels (SeqId = 12691-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine hydroxymethyltransferase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000047 None Gadd-DA_shmt2_protein_levels__seqid___12691-44__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0377705 0.00825068 0.000004735947 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PPIH protein levels (SeqId = 12449-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIH protein levels (SeqId = 12449-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase H 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000048 None Gadd-DA_ppih_protein_levels__seqid___12449-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MTRF1L protein levels (SeqId = 11134-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTRF1L protein levels (SeqId = 11134-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptide chain release factor 1-like, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000048 None Gadd-DA_mtrf1l_protein_levels__seqid___11134-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNM2 protein levels (SeqId = 11572-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNM2 protein levels (SeqId = 11572-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dynamin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000048 None Gadd-DA_dnm2_protein_levels__seqid___11572-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SHC1 protein levels (SeqId = 5272-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SHC1 protein levels (SeqId = 5272-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SHC-transforming protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000049 None Gadd-DA_shc1_protein_levels__seqid___5272-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FAM49B protein levels (SeqId = 19176-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM49B protein levels (SeqId = 19176-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein FAM49B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.0000049 None Gadd-DA_fam49b_protein_levels__seqid___19176-27__somascan_protein_measurement Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.00023162 5.07e-05 0.00000498 - 27843151_alcohol_consumption_per_day_european_ancestry Gadd DA Generation Scotland 35945220 31/07/2022 MAX protein levels (SeqId = 12411-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAX protein levels (SeqId = 12411-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein max 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.000005 None Gadd-DA_max_protein_levels__seqid___12411-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNRPG protein levels (SeqId = 19276-124) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNRPG protein levels (SeqId = 19276-124) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small nuclear ribonucleoprotein G 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.64 0.139 0.000005 None Gadd-DA_snrpg_protein_levels__seqid___19276-124__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSNK2A1 protein levels (SeqId = 5225-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSNK2A1 protein levels (SeqId = 5225-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Casein kinase II subunit beta|Casein kinase II subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.000005 None Gadd-DA_csnk2a1_protein_levels__seqid___5225-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0376659 0.00825071 0.000005031587 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0594108 0.0130177 0.000005062788 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 COL4A3BP protein levels (SeqId = 13535-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL4A3BP protein levels (SeqId = 13535-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen type IV alpha-3-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000051 None Gadd-DA_col4a3bp_protein_levels__seqid___13535-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAT6 protein levels (SeqId = 10372-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAT6 protein levels (SeqId = 10372-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal transducer and activator of transcription 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.632 0.139 0.0000051 None Gadd-DA_stat6_protein_levels__seqid___10372-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EPS15L1 protein levels (SeqId = 4212-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EPS15L1 protein levels (SeqId = 4212-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Epidermal growth factor receptor substrate 15-like 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000051 None Gadd-DA_eps15l1_protein_levels__seqid___4212-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0376263 0.00825072 0.000005147806 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0504476 0.0110662 0.000005188865 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPM protein levels (SeqId = 12783-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPM protein levels (SeqId = 12783-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein M 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000053 None Gadd-DA_hnrnpm_protein_levels__seqid___12783-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CBL protein levels (SeqId = 12016-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBL protein levels (SeqId = 12016-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase CBL 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000053 None Gadd-DA_cbl_protein_levels__seqid___12016-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACE2 protein levels (SeqId = 2805-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACE2 protein levels (SeqId = 2805-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Angiotensin-converting enzyme 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000053 None Gadd-DA_ace2_protein_levels__seqid___2805-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPBP protein levels (SeqId = 2790-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPBP protein levels (SeqId = 2790-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet basic protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000053 None Gadd-DA_ppbp_protein_levels__seqid___2790-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMAD1 protein levels (SeqId = 9838-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMAD1 protein levels (SeqId = 9838-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mothers against decapentaplegic homolog 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000054 None Gadd-DA_smad1_protein_levels__seqid___9838-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 OLA1 protein levels (SeqId = 12659-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OLA1 protein levels (SeqId = 12659-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Obg-like ATPase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000054 None Gadd-DA_ola1_protein_levels__seqid___12659-13__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0380062 0.00835941 0.000005497811 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 NME1 protein levels (SeqId = 5909-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NME1 protein levels (SeqId = 5909-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nucleoside diphosphate kinase A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000055 None Gadd-DA_nme1_protein_levels__seqid___5909-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TIAL1 protein levels (SeqId = 19131-184) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TIAL1 protein levels (SeqId = 19131-184) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nucleolysin TIAR 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000055 None Gadd-DA_tial1_protein_levels__seqid___19131-184__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HTRA2 protein levels (SeqId = 3317-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HTRA2 protein levels (SeqId = 3317-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine protease HTRA2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000056 None Gadd-DA_htra2_protein_levels__seqid___3317-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0374631 0.00825078 0.000005655244 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SAR1A protein levels (SeqId = 17726-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SAR1A protein levels (SeqId = 17726-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GTP-binding protein SAR1a 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000057 None Gadd-DA_sar1a_protein_levels__seqid___17726-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CILP protein levels (SeqId = 5717-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CILP protein levels (SeqId = 5717-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cartilage intermediate layer protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000057 None Gadd-DA_cilp_protein_levels__seqid___5717-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIAA1279 protein levels (SeqId = 12956-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA1279 protein levels (SeqId = 12956-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: KIF1-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000057 None Gadd-DA_kiaa1279_protein_levels__seqid___12956-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDAC2 protein levels (SeqId = 18897-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDAC2 protein levels (SeqId = 18897-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone deacetylase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000058 None Gadd-DA_hdac2_protein_levels__seqid___18897-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TSG101 protein levels (SeqId = 13044-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TSG101 protein levels (SeqId = 13044-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor susceptibility gene 101 protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000058 None Gadd-DA_tsg101_protein_levels__seqid___13044-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2F protein levels (SeqId = 18213-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2F protein levels (SeqId = 18213-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NEDD8-conjugating enzyme UBE2F 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000058 None Gadd-DA_ube2f_protein_levels__seqid___18213-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSMA6 protein levels (SeqId = 3860-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMA6 protein levels (SeqId = 3860-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome subunit alpha type-6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000059 None Gadd-DA_psma6_protein_levels__seqid___3860-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NFU1 protein levels (SeqId = 7770-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NFU1 protein levels (SeqId = 7770-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.629 0.139 0.000006 None Gadd-DA_nfu1_protein_levels__seqid___7770-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPOCK1 protein levels (SeqId = 5490-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPOCK1 protein levels (SeqId = 5490-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Testican-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.000006 None Gadd-DA_spock1_protein_levels__seqid___5490-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRPL21 protein levels (SeqId = 8942-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRPL21 protein levels (SeqId = 8942-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 39S ribosomal protein L21, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.000006 None Gadd-DA_mrpl21_protein_levels__seqid___8942-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAP1GDS1 protein levels (SeqId = 14106-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAP1GDS1 protein levels (SeqId = 14106-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rap1 GTPase-GDP dissociation stimulator 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.000006 None Gadd-DA_rap1gds1_protein_levels__seqid___14106-46__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDC42 protein levels (SeqId = 9840-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDC42 protein levels (SeqId = 9840-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cell division control protein 42 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.000006 None Gadd-DA_cdc42_protein_levels__seqid___9840-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0373349 0.00825082 0.000006086965 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 NXF1 protein levels (SeqId = 12453-161) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NXF1 protein levels (SeqId = 12453-161) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear RNA export factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000061 None Gadd-DA_nxf1_protein_levels__seqid___12453-161__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FMR1 protein levels (SeqId = 7713-102) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FMR1 protein levels (SeqId = 7713-102) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synaptic functional regulator FMR1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.138 0.0000062 None Gadd-DA_fmr1_protein_levels__seqid___7713-102__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LANCL1 protein levels (SeqId = 13986-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LANCL1 protein levels (SeqId = 13986-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione S-transferase LANCL1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000062 None Gadd-DA_lancl1_protein_levels__seqid___13986-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SH3BP2 protein levels (SeqId = 7769-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH3BP2 protein levels (SeqId = 7769-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SH3 domain-binding protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000062 None Gadd-DA_sh3bp2_protein_levels__seqid___7769-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C6orf89 protein levels (SeqId = 10885-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C6orf89 protein levels (SeqId = 10885-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bombesin receptor-activated protein C6orf89 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000062 None Gadd-DA_c6orf89_protein_levels__seqid___10885-36__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLEKHA1 protein levels (SeqId = 12459-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLEKHA1 protein levels (SeqId = 12459-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pleckstrin homology domain-containing family A member 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.138 0.0000062 None Gadd-DA_plekha1_protein_levels__seqid___12459-13__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0372993 0.00825083 0.000006212369 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CNP protein levels (SeqId = 6609-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNP protein levels (SeqId = 6609-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000063 None Gadd-DA_cnp_protein_levels__seqid___6609-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KDELC2 protein levels (SeqId = 8296-117) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KDELC2 protein levels (SeqId = 8296-117) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein O-glucosyltransferase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000063 None Gadd-DA_kdelc2_protein_levels__seqid___8296-117__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDPK1 protein levels (SeqId = 4460-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDPK1 protein levels (SeqId = 4460-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-phosphoinositide-dependent protein kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000063 None Gadd-DA_pdpk1_protein_levels__seqid___4460-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSNK1G2 protein levels (SeqId = 12653-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSNK1G2 protein levels (SeqId = 12653-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Casein kinase I isoform gamma-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000063 None Gadd-DA_csnk1g2_protein_levels__seqid___12653-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARL6IP5 protein levels (SeqId = 13503-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARL6IP5 protein levels (SeqId = 13503-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PRA1 family protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000064 None Gadd-DA_arl6ip5_protein_levels__seqid___13503-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB3D protein levels (SeqId = 19379-154) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB3D protein levels (SeqId = 19379-154) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-3D 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000064 None Gadd-DA_rab3d_protein_levels__seqid___19379-154__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 QDPR protein levels (SeqId = 11257-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QDPR protein levels (SeqId = 11257-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dihydropteridine reductase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000064 None Gadd-DA_qdpr_protein_levels__seqid___11257-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STIP1 protein levels (SeqId = 5489-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STIP1 protein levels (SeqId = 5489-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stress-induced-phosphoprotein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000065 None Gadd-DA_stip1_protein_levels__seqid___5489-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GDI1 protein levels (SeqId = 16810-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDI1 protein levels (SeqId = 16810-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rab GDP dissociation inhibitor alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000066 None Gadd-DA_gdi1_protein_levels__seqid___16810-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 YEATS4 protein levels (SeqId = 17474-106) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 YEATS4 protein levels (SeqId = 17474-106) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: YEATS domain-containing protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000066 None Gadd-DA_yeats4_protein_levels__seqid___17474-106__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLOD2 protein levels (SeqId = 6923-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLOD2 protein levels (SeqId = 6923-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000066 None Gadd-DA_plod2_protein_levels__seqid___6923-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RMDN1 protein levels (SeqId = 7096-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RMDN1 protein levels (SeqId = 7096-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Regulator of microtubule dynamics protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000066 None Gadd-DA_rmdn1_protein_levels__seqid___7096-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PABPC4 protein levels (SeqId = 12603-87) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PABPC4 protein levels (SeqId = 12603-87) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyadenylate-binding protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000067 None Gadd-DA_pabpc4_protein_levels__seqid___12603-87__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FBXL4 protein levels (SeqId = 9951-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FBXL4 protein levels (SeqId = 9951-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: F-box/LRR-repeat protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000069 None Gadd-DA_fbxl4_protein_levels__seqid___9951-36__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MTHFSD protein levels (SeqId = 19129-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTHFSD protein levels (SeqId = 19129-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methenyltetrahydrofolate synthase domain-containing protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000069 None Gadd-DA_mthfsd_protein_levels__seqid___19129-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NMI protein levels (SeqId = 17512-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NMI protein levels (SeqId = 17512-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: N-myc-interactor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000069 None Gadd-DA_nmi_protein_levels__seqid___17512-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0371154 0.00825088 0.000006900843 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HEXIM2 protein levels (SeqId = 14205-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HEXIM2 protein levels (SeqId = 14205-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein HEXIM2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.000007 None Gadd-DA_hexim2_protein_levels__seqid___14205-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ERP29 protein levels (SeqId = 13728-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERP29 protein levels (SeqId = 13728-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endoplasmic reticulum resident protein 29 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000071 None Gadd-DA_erp29_protein_levels__seqid___13728-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZFYVE27 protein levels (SeqId = 9102-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZFYVE27 protein levels (SeqId = 9102-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protrudin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.63 0.139 0.0000072 None Gadd-DA_zfyve27_protein_levels__seqid___9102-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLEC4G protein levels (SeqId = 10781-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLEC4G protein levels (SeqId = 10781-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-type lectin domain family 4 member G 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000072 None Gadd-DA_clec4g_protein_levels__seqid___10781-19__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0370341 0.00825091 0.000007227661 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0370008 0.00825092 0.000007365614 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 INPP5B protein levels (SeqId = 12641-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 INPP5B protein levels (SeqId = 12641-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Type II inositol 1,4,5-trisphosphate 5-phosphatase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000074 None Gadd-DA_inpp5b_protein_levels__seqid___12641-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDHD3 protein levels (SeqId = 19482-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDHD3 protein levels (SeqId = 19482-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Haloacid dehalogenase-like hydrolase domain-containing protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000075 None Gadd-DA_hdhd3_protein_levels__seqid___19482-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PEAR1 protein levels (SeqId = 8892-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PEAR1 protein levels (SeqId = 8892-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet endothelial aggregation receptor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000075 None Gadd-DA_pear1_protein_levels__seqid___8892-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IGBP1 protein levels (SeqId = 12358-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGBP1 protein levels (SeqId = 12358-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Immunoglobulin-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000075 None Gadd-DA_igbp1_protein_levels__seqid___12358-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0369557 0.00825093 0.000007556983 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC17 protein levels (SeqId = 14655-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC17 protein levels (SeqId = 14655-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 17 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000076 None Gadd-DA_dnajc17_protein_levels__seqid___14655-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARHGEF1 protein levels (SeqId = 13976-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGEF1 protein levels (SeqId = 13976-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho guanine nucleotide exchange factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000076 None Gadd-DA_arhgef1_protein_levels__seqid___13976-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CUL1 protein levels (SeqId = 17797-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CUL1 protein levels (SeqId = 17797-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cullin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000076 None Gadd-DA_cul1_protein_levels__seqid___17797-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPK14 protein levels (SeqId = 5007-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPK14 protein levels (SeqId = 5007-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitogen-activated protein kinase 14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000076 None Gadd-DA_mapk14_protein_levels__seqid___5007-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH3B1 protein levels (SeqId = 12940-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH3B1 protein levels (SeqId = 12940-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldehyde dehydrogenase family 3 member B1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000077 None Gadd-DA_aldh3b1_protein_levels__seqid___12940-35__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ATOX1 protein levels (SeqId = 19233-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ATOX1 protein levels (SeqId = 19233-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Copper transport protein ATOX1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.624 0.139 0.0000077 None Gadd-DA_atox1_protein_levels__seqid___19233-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ASCC1 protein levels (SeqId = 10647-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASCC1 protein levels (SeqId = 10647-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activating signal cointegrator 1 complex subunit 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000078 None Gadd-DA_ascc1_protein_levels__seqid___10647-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDKN2D protein levels (SeqId = 12376-85) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDKN2D protein levels (SeqId = 12376-85) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinase 4 inhibitor D 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000079 None Gadd-DA_cdkn2d_protein_levels__seqid___12376-85__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CAMK4 protein levels (SeqId = 18904-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CAMK4 protein levels (SeqId = 18904-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcium/calmodulin-dependent protein kinase type IV 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000079 None Gadd-DA_camk4_protein_levels__seqid___18904-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RANBP3 protein levels (SeqId = 14037-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RANBP3 protein levels (SeqId = 14037-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ran-binding protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.138 0.000008 None Gadd-DA_ranbp3_protein_levels__seqid___14037-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SYT17 protein levels (SeqId = 9110-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYT17 protein levels (SeqId = 9110-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synaptotagmin-17 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000081 None Gadd-DA_syt17_protein_levels__seqid___9110-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14480637 chr14:88455413 14 88455413 GALC North shelf 0.0368227 0.00825097 0.000008148557 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0368166 0.00825097 0.000008176843 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ISG15 protein levels (SeqId = 14151-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ISG15 protein levels (SeqId = 14151-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-like protein ISG15 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000082 None Gadd-DA_isg15_protein_levels__seqid___14151-4__somascan_protein_measurement Cardenas A Project Viva 31300640 Jul 12, 2019 current asthma MONDO_0004979 None Table 3, Supplementary Data 1 DNA methylation current asthma Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values None Illumina HumanMethylationEPIC nasal epithelium None 463 1 Children Both Other cg04738877 chr14:88459963 14 88459963 GALC South shore -1.67 0.37 0.0000083 None 31300640_Cardenas-A_current_asthma Gadd DA Generation Scotland 35945220 31/07/2022 RPS6KB1 protein levels (SeqId = 15608-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS6KB1 protein levels (SeqId = 15608-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribosomal protein S6 kinase beta-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000083 None Gadd-DA_rps6kb1_protein_levels__seqid___15608-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PHF3 protein levels (SeqId = 11544-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PHF3 protein levels (SeqId = 11544-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PHD finger protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.138 0.0000083 None Gadd-DA_phf3_protein_levels__seqid___11544-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRK protein levels (SeqId = 4976-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRK protein levels (SeqId = 4976-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adapter molecule crk 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000083 None Gadd-DA_crk_protein_levels__seqid___4976-57__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0977446 0.0219319 0.000008383924 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 NAPA protein levels (SeqId = 4292-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAPA protein levels (SeqId = 4292-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-soluble NSF attachment protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000084 None Gadd-DA_napa_protein_levels__seqid___4292-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPAB protein levels (SeqId = 8894-80) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPAB protein levels (SeqId = 8894-80) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein A/B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000084 None Gadd-DA_hnrnpab_protein_levels__seqid___8894-80__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CENPW protein levels (SeqId = 8864-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CENPW protein levels (SeqId = 8864-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Centromere protein W 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000084 None Gadd-DA_cenpw_protein_levels__seqid___8864-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CKS1B protein levels (SeqId = 12530-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CKS1B protein levels (SeqId = 12530-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinases regulatory subunit 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000084 None Gadd-DA_cks1b_protein_levels__seqid___12530-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RDX protein levels (SeqId = 18373-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RDX protein levels (SeqId = 18373-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Radixin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000085 None Gadd-DA_rdx_protein_levels__seqid___18373-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARFIP1 protein levels (SeqId = 13488-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARFIP1 protein levels (SeqId = 13488-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Arfaptin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.138 0.0000085 None Gadd-DA_arfip1_protein_levels__seqid___13488-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0367467 0.008251 0.00000850637 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PLCB1 protein levels (SeqId = 11354-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLCB1 protein levels (SeqId = 11354-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000086 None Gadd-DA_plcb1_protein_levels__seqid___11354-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF4 protein levels (SeqId = 4123-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF4 protein levels (SeqId = 4123-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.606 0.136 0.0000086 None Gadd-DA_fgf4_protein_levels__seqid___4123-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SELP protein levels (SeqId = 4154-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SELP protein levels (SeqId = 4154-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: P-selectin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000086 None Gadd-DA_selp_protein_levels__seqid___4154-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DARS2 protein levels (SeqId = 12395-86) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DARS2 protein levels (SeqId = 12395-86) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aspartate--tRNA ligase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000086 None Gadd-DA_dars2_protein_levels__seqid___12395-86__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0367197 0.008251 0.000008636801 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SNRPA protein levels (SeqId = 12678-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNRPA protein levels (SeqId = 12678-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: U1 small nuclear ribonucleoprotein A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000087 None Gadd-DA_snrpa_protein_levels__seqid___12678-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ERH protein levels (SeqId = 11614-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERH protein levels (SeqId = 11614-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Enhancer of rudimentary homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000087 None Gadd-DA_erh_protein_levels__seqid___11614-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VPS4A protein levels (SeqId = 11476-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VPS4A protein levels (SeqId = 11476-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vacuolar protein sorting-associated protein 4A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000087 None Gadd-DA_vps4a_protein_levels__seqid___11476-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 G6PD protein levels (SeqId = 19297-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 G6PD protein levels (SeqId = 19297-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glucose-6-phosphate 1-dehydrogenase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000088 None Gadd-DA_g6pd_protein_levels__seqid___19297-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BRSK2 protein levels (SeqId = 9790-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BRSK2 protein levels (SeqId = 9790-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase BRSK2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000088 None Gadd-DA_brsk2_protein_levels__seqid___9790-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD68 protein levels (SeqId = 18922-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD68 protein levels (SeqId = 18922-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Macrosialin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.616 0.139 0.0000088 None Gadd-DA_cd68_protein_levels__seqid___18922-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2V2 protein levels (SeqId = 18165-181) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2V2 protein levels (SeqId = 18165-181) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 variant 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000088 None Gadd-DA_ube2v2_protein_levels__seqid___18165-181__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0366763 0.00825102 0.00000885099 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AKR1A1 protein levels (SeqId = 4192-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR1A1 protein levels (SeqId = 4192-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldo-keto reductase family 1 member A1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.000009 None Gadd-DA_akr1a1_protein_levels__seqid___4192-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLD3 protein levels (SeqId = 10948-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLD3 protein levels (SeqId = 10948-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phospholipase D3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.138 0.0000091 None Gadd-DA_pld3_protein_levels__seqid___10948-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APBB2 protein levels (SeqId = 12753-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APBB2 protein levels (SeqId = 12753-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.618 0.139 0.0000092 None Gadd-DA_apbb2_protein_levels__seqid___12753-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPF protein levels (SeqId = 9764-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPF protein levels (SeqId = 9764-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein F 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000092 None Gadd-DA_hnrnpf_protein_levels__seqid___9764-79__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0418012 0.00942321 0.000009231883 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 FIBP protein levels (SeqId = 19169-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FIBP protein levels (SeqId = 19169-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acidic fibroblast growth factor intracellular-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000093 None Gadd-DA_fibp_protein_levels__seqid___19169-88__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C10orf54 protein levels (SeqId = 14123-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C10orf54 protein levels (SeqId = 14123-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: V-type immunoglobulin domain-containing suppressor of T-cell activation 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.0000094 None Gadd-DA_c10orf54_protein_levels__seqid___14123-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLXDC2 protein levels (SeqId = 11342-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLXDC2 protein levels (SeqId = 11342-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Plexin domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.138 0.0000094 None Gadd-DA_plxdc2_protein_levels__seqid___11342-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF4B protein levels (SeqId = 14675-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF4B protein levels (SeqId = 14675-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 4B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.0000095 None Gadd-DA_eif4b_protein_levels__seqid___14675-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMAD2 protein levels (SeqId = 10364-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMAD2 protein levels (SeqId = 10364-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mothers against decapentaplegic homolog 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.0000095 None Gadd-DA_smad2_protein_levels__seqid___10364-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIP4K2B protein levels (SeqId = 18232-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIP4K2B protein levels (SeqId = 18232-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.0000096 None Gadd-DA_pip4k2b_protein_levels__seqid___18232-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0502388 0.0113532 0.000009710414 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ID2 protein levels (SeqId = 15403-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ID2 protein levels (SeqId = 15403-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA-binding protein inhibitor ID-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.614 0.139 0.0000098 None Gadd-DA_id2_protein_levels__seqid___15403-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF3J protein levels (SeqId = 13497-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF3J protein levels (SeqId = 13497-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 3 subunit J 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.00001 None Gadd-DA_eif3j_protein_levels__seqid___13497-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TEX29 protein levels (SeqId = 10557-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TEX29 protein levels (SeqId = 10557-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Testis-expressed protein 29 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.62 0.139 0.00001 None Gadd-DA_tex29_protein_levels__seqid___10557-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PYGL protein levels (SeqId = 11441-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PYGL protein levels (SeqId = 11441-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycogen phosphorylase, liver form 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_pygl_protein_levels__seqid___11441-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNUPN protein levels (SeqId = 17765-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNUPN protein levels (SeqId = 17765-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Snurportin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_snupn_protein_levels__seqid___17765-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STMN2 protein levels (SeqId = 10900-272) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STMN2 protein levels (SeqId = 10900-272) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stathmin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_stmn2_protein_levels__seqid___10900-272__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAR protein levels (SeqId = 10085-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAR protein levels (SeqId = 10085-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Steroidogenic acute regulatory protein, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_star_protein_levels__seqid___10085-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACBD6 protein levels (SeqId = 10075-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACBD6 protein levels (SeqId = 10075-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acyl-CoA-binding domain-containing protein 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_acbd6_protein_levels__seqid___10075-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAP2K3 protein levels (SeqId = 6151-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAP2K3 protein levels (SeqId = 6151-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_map2k3_protein_levels__seqid___6151-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TAF15 protein levels (SeqId = 16865-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TAF15 protein levels (SeqId = 16865-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: TATA-binding protein-associated factor 2N 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_taf15_protein_levels__seqid___16865-62__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AMPD2 protein levels (SeqId = 18403-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AMPD2 protein levels (SeqId = 18403-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: AMP deaminase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_ampd2_protein_levels__seqid___18403-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMIM9 protein levels (SeqId = 8888-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMIM9 protein levels (SeqId = 8888-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small integral membrane protein 9 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_smim9_protein_levels__seqid___8888-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIF23 protein levels (SeqId = 5228-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIF23 protein levels (SeqId = 5228-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kinesin-like protein KIF23 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_kif23_protein_levels__seqid___5228-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GHRH protein levels (SeqId = 16293-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GHRH protein levels (SeqId = 16293-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Somatoliberin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.00001 None Gadd-DA_ghrh_protein_levels__seqid___16293-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.036448 0.00825109 0.00001006313 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HPSE protein levels (SeqId = 5604-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HPSE protein levels (SeqId = 5604-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparanase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_hpse_protein_levels__seqid___5604-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITSN1 protein levels (SeqId = 14070-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITSN1 protein levels (SeqId = 14070-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Intersectin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_itsn1_protein_levels__seqid___14070-56__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2E1 protein levels (SeqId = 14326-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2E1 protein levels (SeqId = 14326-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 E1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_ube2e1_protein_levels__seqid___14326-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2V1 protein levels (SeqId = 11626-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2V1 protein levels (SeqId = 11626-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 variant 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_ube2v1_protein_levels__seqid___11626-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBXN4 protein levels (SeqId = 9997-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBXN4 protein levels (SeqId = 9997-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UBX domain-containing protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_ubxn4_protein_levels__seqid___9997-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNAJB2 protein levels (SeqId = 11438-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJB2 protein levels (SeqId = 11438-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily B member 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_dnajb2_protein_levels__seqid___11438-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARHGAP1 protein levels (SeqId = 9815-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGAP1 protein levels (SeqId = 9815-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho GTPase-activating protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_arhgap1_protein_levels__seqid___9815-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDHD2 protein levels (SeqId = 13472-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDHD2 protein levels (SeqId = 13472-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Haloacid dehalogenase-like hydrolase domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_hdhd2_protein_levels__seqid___13472-35__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIK3CA protein levels (SeqId = 3390-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIK3CA protein levels (SeqId = 3390-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|Phosphatidylinositol 3-kinase regulatory subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_pik3ca_protein_levels__seqid___3390-72__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 USP15 protein levels (SeqId = 19161-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 USP15 protein levels (SeqId = 19161-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin carboxyl-terminal hydrolase 15 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_usp15_protein_levels__seqid___19161-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKAA2 protein levels (SeqId = 5245-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKAA2 protein levels (SeqId = 5245-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 5'-AMP-activated protein kinase subunit beta-2|5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase subunit gamma-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_prkaa2_protein_levels__seqid___5245-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SIRT3 protein levels (SeqId = 17495-141) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIRT3 protein levels (SeqId = 17495-141) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_sirt3_protein_levels__seqid___17495-141__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRE11A protein levels (SeqId = 11319-106) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRE11A protein levels (SeqId = 11319-106) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Double-strand break repair protein MRE11 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_mre11a_protein_levels__seqid___11319-106__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CFL1 protein levels (SeqId = 4203-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFL1 protein levels (SeqId = 4203-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cofilin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_cfl1_protein_levels__seqid___4203-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IST1 protein levels (SeqId = 12434-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IST1 protein levels (SeqId = 12434-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: IST1 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000011 None Gadd-DA_ist1_protein_levels__seqid___12434-25__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.223048 0.0508113 0.00001141651 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07695256 chr14:88459742 14 88459742 GALC South shore 0.176465 0.0402245 0.00001156112 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04052570 chr14:88459528 14 88459528 GALC Island 0.0004 0.00009 0.000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 PAPSS1 protein levels (SeqId = 14007-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPSS1 protein levels (SeqId = 14007-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_papss1_protein_levels__seqid___14007-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FEV protein levels (SeqId = 12740-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FEV protein levels (SeqId = 12740-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein FEV 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_fev_protein_levels__seqid___12740-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MANF protein levels (SeqId = 9223-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MANF protein levels (SeqId = 9223-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mesencephalic astrocyte-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_manf_protein_levels__seqid___9223-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SEPHS1 protein levels (SeqId = 14083-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SEPHS1 protein levels (SeqId = 14083-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Selenide, water dikinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_sephs1_protein_levels__seqid___14083-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TCF4 protein levels (SeqId = 19144-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TCF4 protein levels (SeqId = 19144-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription factor 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_tcf4_protein_levels__seqid___19144-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GZMK protein levels (SeqId = 9545-156) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMK protein levels (SeqId = 9545-156) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme K 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TBL2 protein levels (SeqId = 11227-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TBL2 protein levels (SeqId = 11227-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transducin beta-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_tbl2_protein_levels__seqid___11227-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TSSC4 protein levels (SeqId = 18181-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TSSC4 protein levels (SeqId = 18181-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein TSSC4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_tssc4_protein_levels__seqid___18181-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHMP2A protein levels (SeqId = 17728-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHMP2A protein levels (SeqId = 17728-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Charged multivesicular body protein 2a 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_chmp2a_protein_levels__seqid___17728-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CACYBP protein levels (SeqId = 12432-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CACYBP protein levels (SeqId = 12432-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcyclin-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_cacybp_protein_levels__seqid___12432-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MCL1 protein levels (SeqId = 10396-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MCL1 protein levels (SeqId = 10396-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Induced myeloid leukemia cell differentiation protein Mcl-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_mcl1_protein_levels__seqid___10396-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TTL protein levels (SeqId = 13973-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTL protein levels (SeqId = 13973-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tubulin--tyrosine ligase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.607 0.139 0.000012 None Gadd-DA_ttl_protein_levels__seqid___13973-62__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRKL protein levels (SeqId = 9877-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRKL protein levels (SeqId = 9877-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Crk-like protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_crkl_protein_levels__seqid___9877-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NAPG protein levels (SeqId = 17773-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAPG protein levels (SeqId = 17773-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gamma-soluble NSF attachment protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_napg_protein_levels__seqid___17773-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ST6GAL1 protein levels (SeqId = 6035-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST6GAL1 protein levels (SeqId = 6035-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-galactoside alpha-2,6-sialyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_st6gal1_protein_levels__seqid___6035-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPP3R1 protein levels (SeqId = 15545-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPP3R1 protein levels (SeqId = 15545-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcineurin subunit B type 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_ppp3r1_protein_levels__seqid___15545-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BRICD5 protein levels (SeqId = 6612-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BRICD5 protein levels (SeqId = 6612-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BRICHOS domain-containing protein 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_bricd5_protein_levels__seqid___6612-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MANBA protein levels (SeqId = 6382-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MANBA protein levels (SeqId = 6382-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-mannosidase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_manba_protein_levels__seqid___6382-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB5A protein levels (SeqId = 17205-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB5A protein levels (SeqId = 17205-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-5A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_rab5a_protein_levels__seqid___17205-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APP protein levels (SeqId = 3171-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APP protein levels (SeqId = 3171-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Amyloid-beta precursor protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_app_protein_levels__seqid___3171-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARHGAP5 protein levels (SeqId = 14748-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGAP5 protein levels (SeqId = 14748-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho GTPase-activating protein 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_arhgap5_protein_levels__seqid___14748-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDC2 protein levels (SeqId = 3422-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDC2 protein levels (SeqId = 3422-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinase 1|G2/mitotic-specific cyclin-B1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.607 0.139 0.000012 None Gadd-DA_cdc2_protein_levels__seqid___3422-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSP90AA1 protein levels (SeqId = 2625-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSP90AA1 protein levels (SeqId = 2625-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock protein HSP 90-alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000012 None Gadd-DA_hsp90aa1_protein_levels__seqid___2625-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.0627746 0.0143576 0.00001238351 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0360744 0.0082512 0.00001239463 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0394349 0.00902899 0.0000126487 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore -0.03602 0.00825121 0.00001277492 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AIP protein levels (SeqId = 3839-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AIP protein levels (SeqId = 3839-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: AH receptor-interacting protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_aip_protein_levels__seqid___3839-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDCD5 protein levels (SeqId = 12517-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDCD5 protein levels (SeqId = 12517-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Programmed cell death protein 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_pdcd5_protein_levels__seqid___12517-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNRC6B protein levels (SeqId = 9808-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNRC6B protein levels (SeqId = 9808-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trinucleotide repeat-containing gene 6B protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_tnrc6b_protein_levels__seqid___9808-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARL3 protein levels (SeqId = 12571-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARL3 protein levels (SeqId = 12571-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-like protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_arl3_protein_levels__seqid___12571-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF41 protein levels (SeqId = 13411-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF41 protein levels (SeqId = 13411-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase NRDP1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.609 0.139 0.000013 None Gadd-DA_rnf41_protein_levels__seqid___13411-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HADH protein levels (SeqId = 17739-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HADH protein levels (SeqId = 17739-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_hadh_protein_levels__seqid___17739-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBQLN4 protein levels (SeqId = 12720-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBQLN4 protein levels (SeqId = 12720-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquilin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_ubqln4_protein_levels__seqid___12720-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EDC4 protein levels (SeqId = 13066-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EDC4 protein levels (SeqId = 13066-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Enhancer of mRNA-decapping protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_edc4_protein_levels__seqid___13066-42__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDT3 protein levels (SeqId = 12796-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDT3 protein levels (SeqId = 12796-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Diphosphoinositol polyphosphate phosphohydrolase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_nudt3_protein_levels__seqid___12796-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSPA9 protein levels (SeqId = 13492-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPA9 protein levels (SeqId = 13492-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stress-70 protein, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_hspa9_protein_levels__seqid___13492-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYDGF protein levels (SeqId = 9248-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYDGF protein levels (SeqId = 9248-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myeloid-derived growth factor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_mydgf_protein_levels__seqid___9248-36__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MTHFS protein levels (SeqId = 14107-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTHFS protein levels (SeqId = 14107-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 5-formyltetrahydrofolate cyclo-ligase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_mthfs_protein_levels__seqid___14107-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FLRT3 protein levels (SeqId = 9128-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FLRT3 protein levels (SeqId = 9128-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat transmembrane protein FLRT3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_flrt3_protein_levels__seqid___9128-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPOCK3 protein levels (SeqId = 9906-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPOCK3 protein levels (SeqId = 9906-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Testican-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_spock3_protein_levels__seqid___9906-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCL2A1 protein levels (SeqId = 3413-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCL2A1 protein levels (SeqId = 3413-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bcl-2-related protein A1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_bcl2a1_protein_levels__seqid___3413-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXNDC12 protein levels (SeqId = 19334-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNDC12 protein levels (SeqId = 19334-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin domain-containing protein 12 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_txndc12_protein_levels__seqid___19334-62__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACP1 protein levels (SeqId = 3858-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACP1 protein levels (SeqId = 3858-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low molecular weight phosphotyrosine protein phosphatase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000013 None Gadd-DA_acp1_protein_levels__seqid___3858-5__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg21274300 chr14:88459745 14 88459745 GALC South shore 3.4 0.786 0.000013 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea 0.0359881 0.00825122 0.00001300251 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21274300 chr14:88459745 14 88459745 GALC South shore 0.152167 0.0348923 0.00001301968 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13190415 chr14:88437623 14 88437623 GALC Open sea 0.0359734 0.00825123 0.00001310921 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0399781 0.00918918 0.00001367058 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0358556 0.00825126 0.00001399168 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AP2A2 protein levels (SeqId = 13621-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AP2A2 protein levels (SeqId = 13621-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: AP-2 complex subunit alpha-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_ap2a2_protein_levels__seqid___13621-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRPS2 protein levels (SeqId = 18329-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRPS2 protein levels (SeqId = 18329-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribose-phosphate pyrophosphokinase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000014 None Gadd-DA_prps2_protein_levels__seqid___18329-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CFC1 protein levels (SeqId = 3294-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFC1 protein levels (SeqId = 3294-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cryptic protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000014 None Gadd-DA_cfc1_protein_levels__seqid___3294-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SYF2 protein levels (SeqId = 19438-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYF2 protein levels (SeqId = 19438-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pre-mRNA-splicing factor SYF2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_syf2_protein_levels__seqid___19438-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BLVRA protein levels (SeqId = 11382-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BLVRA protein levels (SeqId = 11382-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Biliverdin reductase A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.61 0.139 0.000014 None Gadd-DA_blvra_protein_levels__seqid___11382-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 YWHAB protein levels (SeqId = 14156-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 YWHAB protein levels (SeqId = 14156-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 14-3-3 protein beta/alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_ywhab_protein_levels__seqid___14156-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 WWP1 protein levels (SeqId = 11307-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WWP1 protein levels (SeqId = 11307-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NEDD4-like E3 ubiquitin-protein ligase WWP1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.138 0.000014 None Gadd-DA_wwp1_protein_levels__seqid___11307-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANGPT1 protein levels (SeqId = 2811-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANGPT1 protein levels (SeqId = 2811-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Angiopoietin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_angpt1_protein_levels__seqid___2811-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FOXM1 protein levels (SeqId = 10056-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FOXM1 protein levels (SeqId = 10056-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Forkhead box protein M1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_foxm1_protein_levels__seqid___10056-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 XRCC6 protein levels (SeqId = 2835-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 XRCC6 protein levels (SeqId = 2835-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: X-ray repair cross-complementing protein 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_xrcc6_protein_levels__seqid___2835-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDIA5 protein levels (SeqId = 5593-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDIA5 protein levels (SeqId = 5593-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase A5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.138 0.000014 None Gadd-DA_pdia5_protein_levels__seqid___5593-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCDC134 protein levels (SeqId = 15300-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCDC134 protein levels (SeqId = 15300-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coiled-coil domain-containing protein 134 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_ccdc134_protein_levels__seqid___15300-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RASA1 protein levels (SeqId = 5481-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RASA1 protein levels (SeqId = 5481-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras GTPase-activating protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_rasa1_protein_levels__seqid___5481-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 INPP5E protein levels (SeqId = 11370-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 INPP5E protein levels (SeqId = 11370-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 72 kDa inositol polyphosphate 5-phosphatase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_inpp5e_protein_levels__seqid___11370-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARL6 protein levels (SeqId = 18415-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARL6 protein levels (SeqId = 18415-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-like protein 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000014 None Gadd-DA_arl6_protein_levels__seqid___18415-16__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0949867 0.0219073 0.00001461758 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0371835 0.00858629 0.00001497113 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 TMEFF1 protein levels (SeqId = 15641-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEFF1 protein levels (SeqId = 15641-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tomoregulin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.603 0.139 0.000015 None Gadd-DA_tmeff1_protein_levels__seqid___15641-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TAPBP protein levels (SeqId = 12378-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TAPBP protein levels (SeqId = 12378-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tapasin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_tapbp_protein_levels__seqid___12378-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCL5 protein levels (SeqId = 5480-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCL5 protein levels (SeqId = 5480-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-C motif chemokine 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_ccl5_protein_levels__seqid___5480-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPT1 protein levels (SeqId = 9244-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPT1 protein levels (SeqId = 9244-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Palmitoyl-protein thioesterase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_ppt1_protein_levels__seqid___9244-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLEC1B protein levels (SeqId = 4332-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLEC1B protein levels (SeqId = 4332-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-type lectin domain family 1 member B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_clec1b_protein_levels__seqid___4332-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DLG2 protein levels (SeqId = 19620-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DLG2 protein levels (SeqId = 19620-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Disks large homolog 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_dlg2_protein_levels__seqid___19620-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SH3GL3 protein levels (SeqId = 18318-98) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH3GL3 protein levels (SeqId = 18318-98) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endophilin-A3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_sh3gl3_protein_levels__seqid___18318-98__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RSPO2 protein levels (SeqId = 4566-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RSPO2 protein levels (SeqId = 4566-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: R-spondin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_rspo2_protein_levels__seqid___4566-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRR16 protein levels (SeqId = 10621-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRR16 protein levels (SeqId = 10621-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein Largen 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_prr16_protein_levels__seqid___10621-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COMMD9 protein levels (SeqId = 17683-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COMMD9 protein levels (SeqId = 17683-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: COMM domain-containing protein 9 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_commd9_protein_levels__seqid___17683-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TARBP2 protein levels (SeqId = 12781-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TARBP2 protein levels (SeqId = 12781-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RISC-loading complex subunit TARBP2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.138 0.000015 None Gadd-DA_tarbp2_protein_levels__seqid___12781-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PAWR protein levels (SeqId = 9565-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAWR protein levels (SeqId = 9565-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PRKC apoptosis WT1 regulator protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000015 None Gadd-DA_pawr_protein_levels__seqid___9565-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0482732 0.0111596 0.00001530595 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0370537 0.00857054 0.00001546714 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CASP3 protein levels (SeqId = 3593-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CASP3 protein levels (SeqId = 3593-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Caspase-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_casp3_protein_levels__seqid___3593-72__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DDX19A protein levels (SeqId = 18813-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DDX19A protein levels (SeqId = 18813-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATP-dependent RNA helicase DDX19A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_ddx19a_protein_levels__seqid___18813-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STARD5 protein levels (SeqId = 17383-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STARD5 protein levels (SeqId = 17383-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: StAR-related lipid transfer protein 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.598 0.139 0.000016 None Gadd-DA_stard5_protein_levels__seqid___17383-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ENAH protein levels (SeqId = 9757-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ENAH protein levels (SeqId = 9757-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein enabled homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_enah_protein_levels__seqid___9757-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPK9 protein levels (SeqId = 15604-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPK9 protein levels (SeqId = 15604-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitogen-activated protein kinase 9 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_mapk9_protein_levels__seqid___15604-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARL5A protein levels (SeqId = 18414-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARL5A protein levels (SeqId = 18414-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-like protein 5A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_arl5a_protein_levels__seqid___18414-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF2B1 protein levels (SeqId = 10080-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF2B1 protein levels (SeqId = 10080-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Translation initiation factor eIF-2B subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_eif2b1_protein_levels__seqid___10080-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SKIL protein levels (SeqId = 14670-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SKIL protein levels (SeqId = 14670-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ski-like protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_skil_protein_levels__seqid___14670-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UFD1L protein levels (SeqId = 17411-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UFD1L protein levels (SeqId = 17411-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin recognition factor in ER-associated degradation protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_ufd1l_protein_levels__seqid___17411-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NPLOC4 protein levels (SeqId = 12993-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPLOC4 protein levels (SeqId = 12993-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear protein localization protein 4 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_nploc4_protein_levels__seqid___12993-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BAG4 protein levels (SeqId = 12844-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAG4 protein levels (SeqId = 12844-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BAG family molecular chaperone regulator 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_bag4_protein_levels__seqid___12844-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC30 protein levels (SeqId = 7866-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC30 protein levels (SeqId = 7866-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 30, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_dnajc30_protein_levels__seqid___7866-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB14 protein levels (SeqId = 14283-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB14 protein levels (SeqId = 14283-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-14 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_rab14_protein_levels__seqid___14283-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB1B protein levels (SeqId = 19278-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB1B protein levels (SeqId = 19278-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-1B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000016 None Gadd-DA_rab1b_protein_levels__seqid___19278-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB6B protein levels (SeqId = 14271-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB6B protein levels (SeqId = 14271-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-6B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.138 0.000017 None Gadd-DA_rab6b_protein_levels__seqid___14271-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HS3ST3A1 protein levels (SeqId = 8268-98) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HS3ST3A1 protein levels (SeqId = 8268-98) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_hs3st3a1_protein_levels__seqid___8268-98__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BMX protein levels (SeqId = 3414-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMX protein levels (SeqId = 3414-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytoplasmic tyrosine-protein kinase BMX 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_bmx_protein_levels__seqid___3414-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VAV3 protein levels (SeqId = 9830-109) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VAV3 protein levels (SeqId = 9830-109) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide exchange factor VAV3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_vav3_protein_levels__seqid___9830-109__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SBDS protein levels (SeqId = 3866-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SBDS protein levels (SeqId = 3866-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribosome maturation protein SBDS 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_sbds_protein_levels__seqid___3866-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPBP protein levels (SeqId = 4544-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPBP protein levels (SeqId = 4544-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet basic protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_ppbp_protein_levels__seqid___4544-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ELK1 protein levels (SeqId = 10006-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ELK1 protein levels (SeqId = 10006-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ETS domain-containing protein Elk-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_elk1_protein_levels__seqid___10006-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACTN1 protein levels (SeqId = 9843-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACTN1 protein levels (SeqId = 9843-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-actinin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_actn1_protein_levels__seqid___9843-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BPNT1 protein levels (SeqId = 17814-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BPNT1 protein levels (SeqId = 17814-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3'(2'),5'-bisphosphate nucleotidase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_bpnt1_protein_levels__seqid___17814-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 REXO2 protein levels (SeqId = 13590-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 REXO2 protein levels (SeqId = 13590-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oligoribonuclease, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000017 None Gadd-DA_rexo2_protein_levels__seqid___13590-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0354895 0.00825137 0.00001710938 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0354889 0.00825137 0.00001711497 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25377313 chr14:88456098 14 88456098 GALC North shelf 0.0354775 0.00825137 0.00001722229 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0406271 0.00945841 0.00001755517 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg10122474 chr14:88459471 14 88459471 GALC Island -0.589746 0.1374 0.0000177 - 27105112_hiv_infection_neutrophils Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.217406 0.0506507 0.00001778005 None 39706196_Hannah-M.-Smith_glucose_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 POR protein levels (SeqId = 2731-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POR protein levels (SeqId = 2731-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADPH--cytochrome P450 reductase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_por_protein_levels__seqid___2731-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDOA protein levels (SeqId = 5864-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOA protein levels (SeqId = 5864-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_aldoa_protein_levels__seqid___5864-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 S100A5 protein levels (SeqId = 15303-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 S100A5 protein levels (SeqId = 15303-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein S100-A5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_s100a5_protein_levels__seqid___15303-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKT1 protein levels (SeqId = 15627-83) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKT1 protein levels (SeqId = 15627-83) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RAC-alpha serine/threonine-protein kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_akt1_protein_levels__seqid___15627-83__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TIMM50 protein levels (SeqId = 7743-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TIMM50 protein levels (SeqId = 7743-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitochondrial import inner membrane translocase subunit TIM50 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_timm50_protein_levels__seqid___7743-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSMG3 protein levels (SeqId = 12729-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSMG3 protein levels (SeqId = 12729-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome assembly chaperone 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.138 0.000018 None Gadd-DA_psmg3_protein_levels__seqid___12729-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYCBP protein levels (SeqId = 19250-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYCBP protein levels (SeqId = 19250-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: c-Myc-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_mycbp_protein_levels__seqid___19250-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SYK protein levels (SeqId = 11378-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYK protein levels (SeqId = 11378-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tyrosine-protein kinase SYK 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_syk_protein_levels__seqid___11378-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NMT2 protein levels (SeqId = 17821-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NMT2 protein levels (SeqId = 17821-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycylpeptide N-tetradecanoyltransferase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000018 None Gadd-DA_nmt2_protein_levels__seqid___17821-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NAP1L4 protein levels (SeqId = 19188-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAP1L4 protein levels (SeqId = 19188-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nucleosome assembly protein 1-like 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000018 None Gadd-DA_nap1l4_protein_levels__seqid___19188-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MADCAM1 protein levels (SeqId = 11258-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MADCAM1 protein levels (SeqId = 11258-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mucosal addressin cell adhesion molecule 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.597 0.139 0.000018 None Gadd-DA_madcam1_protein_levels__seqid___11258-41__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.054985 0.0128242 0.00001817582 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0367325 0.00856995 0.00001829185 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0353172 0.00825142 0.00001879698 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 BCAT2 protein levels (SeqId = 19365-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCAT2 protein levels (SeqId = 19365-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Branched-chain-amino-acid aminotransferase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000019 None Gadd-DA_bcat2_protein_levels__seqid___19365-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SUMO2 protein levels (SeqId = 19555-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUMO2 protein levels (SeqId = 19555-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small ubiquitin-related modifier 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000019 None Gadd-DA_sumo2_protein_levels__seqid___19555-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPBP protein levels (SeqId = 17165-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPBP protein levels (SeqId = 17165-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet basic protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000019 None Gadd-DA_ppbp_protein_levels__seqid___17165-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CYB5R2 protein levels (SeqId = 19143-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CYB5R2 protein levels (SeqId = 19143-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADH-cytochrome b5 reductase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000019 None Gadd-DA_cyb5r2_protein_levels__seqid___19143-38__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFNB3 protein levels (SeqId = 2514-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFNB3 protein levels (SeqId = 2514-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ephrin-B3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000019 None Gadd-DA_efnb3_protein_levels__seqid___2514-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C11orf94 protein levels (SeqId = 8383-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C11orf94 protein levels (SeqId = 8383-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C11orf94 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.6 0.139 0.000019 None Gadd-DA_c11orf94_protein_levels__seqid___8383-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAMBP protein levels (SeqId = 19187-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAMBP protein levels (SeqId = 19187-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: STAM-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000019 None Gadd-DA_stambp_protein_levels__seqid___19187-21__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0352338 0.00825144 0.00001966846 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01822938 chr14:88456162 14 88456162 GALC North shelf 0.157468 0.0369036 0.00001991523 None 39706196_Hannah-M.-Smith_body_fat_discovery Gadd DA Generation Scotland 35945220 31/07/2022 SULT1A3 protein levels (SeqId = 13944-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SULT1A3 protein levels (SeqId = 13944-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sulfotransferase 1A3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_sult1a3_protein_levels__seqid___13944-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SH2D1A protein levels (SeqId = 4567-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH2D1A protein levels (SeqId = 4567-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SH2 domain-containing protein 1A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_sh2d1a_protein_levels__seqid___4567-82__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B3GALT1 protein levels (SeqId = 9541-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B3GALT1 protein levels (SeqId = 9541-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,3-galactosyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_b3galt1_protein_levels__seqid___9541-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FAF2 protein levels (SeqId = 9738-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAF2 protein levels (SeqId = 9738-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: FAS-associated factor 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.138 0.00002 None Gadd-DA_faf2_protein_levels__seqid___9738-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GHRL protein levels (SeqId = 6518-85) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GHRL protein levels (SeqId = 6518-85) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Appetite-regulating hormone 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.138 0.00002 None Gadd-DA_ghrl_protein_levels__seqid___6518-85__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANGPT4 protein levels (SeqId = 2500-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANGPT4 protein levels (SeqId = 2500-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Angiopoietin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.594 0.139 0.00002 None Gadd-DA_angpt4_protein_levels__seqid___2500-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APEX1 protein levels (SeqId = 9849-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APEX1 protein levels (SeqId = 9849-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA-(apurinic or apyrimidinic site) lyase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_apex1_protein_levels__seqid___9849-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPIL1 protein levels (SeqId = 9884-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIL1 protein levels (SeqId = 9884-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase-like 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_ppil1_protein_levels__seqid___9884-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SUMO3 protein levels (SeqId = 14623-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUMO3 protein levels (SeqId = 14623-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small ubiquitin-related modifier 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_sumo3_protein_levels__seqid___14623-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF3G protein levels (SeqId = 11454-87) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF3G protein levels (SeqId = 11454-87) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 3 subunit G 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_eif3g_protein_levels__seqid___11454-87__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BNIP3L protein levels (SeqId = 7835-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BNIP3L protein levels (SeqId = 7835-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.00002 None Gadd-DA_bnip3l_protein_levels__seqid___7835-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PACAP protein levels (SeqId = 16322-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PACAP protein levels (SeqId = 16322-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Marginal zone B- and B1-cell-specific protein 774 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.72 0.168 0.00002 None Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CST1 protein levels (SeqId = 5459-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST1 protein levels (SeqId = 5459-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-SN 774 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -0.64 0.15 0.00002 None Gadd-DA_cst1_protein_levels__seqid___5459-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.0381549 0.00894482 0.00002006285 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0351823 0.00825146 0.00002022678 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0485042 0.0113764 0.00002024517 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 HIPK3 protein levels (SeqId = 19329-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HIPK3 protein levels (SeqId = 19329-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homeodomain-interacting protein kinase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_hipk3_protein_levels__seqid___19329-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 N6AMT1 protein levels (SeqId = 11096-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 N6AMT1 protein levels (SeqId = 11096-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methyltransferase N6AMT1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_n6amt1_protein_levels__seqid___11096-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SDSL protein levels (SeqId = 17777-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SDSL protein levels (SeqId = 17777-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine dehydratase-like 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_sdsl_protein_levels__seqid___17777-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RHOG protein levels (SeqId = 12540-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RHOG protein levels (SeqId = 12540-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho-related GTP-binding protein RhoG 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_rhog_protein_levels__seqid___12540-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PNPO protein levels (SeqId = 17804-102) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PNPO protein levels (SeqId = 17804-102) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyridoxine-5'-phosphate oxidase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_pnpo_protein_levels__seqid___17804-102__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TP53 protein levels (SeqId = 6123-69) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TP53 protein levels (SeqId = 6123-69) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cellular tumor antigen p53 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_tp53_protein_levels__seqid___6123-69__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKT2 protein levels (SeqId = 5360-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKT2 protein levels (SeqId = 5360-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RAC-beta serine/threonine-protein kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_akt2_protein_levels__seqid___5360-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITPKA protein levels (SeqId = 13473-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITPKA protein levels (SeqId = 13473-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inositol-trisphosphate 3-kinase A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.14 0.000021 None Gadd-DA_itpka_protein_levels__seqid___13473-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADRBK1 protein levels (SeqId = 3347-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADRBK1 protein levels (SeqId = 3347-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-adrenergic receptor kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_adrbk1_protein_levels__seqid___3347-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPP2R1A protein levels (SeqId = 12621-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPP2R1A protein levels (SeqId = 12621-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_ppp2r1a_protein_levels__seqid___12621-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BAGE2 protein levels (SeqId = 6294-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAGE2 protein levels (SeqId = 6294-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: B melanoma antigen 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_bage2_protein_levels__seqid___6294-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TPI1 protein levels (SeqId = 4309-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TPI1 protein levels (SeqId = 4309-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Triosephosphate isomerase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_tpi1_protein_levels__seqid___4309-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDLIM1 protein levels (SeqId = 11428-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDLIM1 protein levels (SeqId = 11428-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PDZ and LIM domain protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_pdlim1_protein_levels__seqid___11428-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DCI protein levels (SeqId = 19367-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DCI protein levels (SeqId = 19367-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Enoyl-CoA delta isomerase 1, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000021 None Gadd-DA_dci_protein_levels__seqid___19367-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLPP protein levels (SeqId = 17196-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLPP protein levels (SeqId = 17196-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATP-dependent Clp protease proteolytic subunit, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.592 0.139 0.000021 None Gadd-DA_clpp_protein_levels__seqid___17196-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0365171 0.00858239 0.00002104524 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GP6 protein levels (SeqId = 3194-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GP6 protein levels (SeqId = 3194-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet glycoprotein VI 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000022 None Gadd-DA_gp6_protein_levels__seqid___3194-36__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BAD protein levels (SeqId = 5870-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAD protein levels (SeqId = 5870-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bcl2-associated agonist of cell death 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000022 None Gadd-DA_bad_protein_levels__seqid___5870-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMOD2 protein levels (SeqId = 12853-112) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMOD2 protein levels (SeqId = 12853-112) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tropomodulin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.583 0.137 0.000022 None Gadd-DA_tmod2_protein_levels__seqid___12853-112__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF5 protein levels (SeqId = 2612-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF5 protein levels (SeqId = 2612-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.138 0.000022 None Gadd-DA_eif5_protein_levels__seqid___2612-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZADH2 protein levels (SeqId = 17345-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZADH2 protein levels (SeqId = 17345-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prostaglandin reductase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.589 0.139 0.000022 None Gadd-DA_zadh2_protein_levels__seqid___17345-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SH3BGRL2 protein levels (SeqId = 19113-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH3BGRL2 protein levels (SeqId = 19113-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SH3 domain-binding glutamic acid-rich-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000022 None Gadd-DA_sh3bgrl2_protein_levels__seqid___19113-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MOBKL1A protein levels (SeqId = 19177-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MOBKL1A protein levels (SeqId = 19177-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MOB kinase activator 1B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000022 None Gadd-DA_mobkl1a_protein_levels__seqid___19177-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMEM59L protein levels (SeqId = 9959-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM59L protein levels (SeqId = 9959-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein 59-like 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000022 None Gadd-DA_tmem59l_protein_levels__seqid___9959-60__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.19358 0.0456063 0.00002201324 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0350199 0.00825151 0.00002208647 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ARRB1 protein levels (SeqId = 12643-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARRB1 protein levels (SeqId = 12643-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-arrestin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_arrb1_protein_levels__seqid___12643-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAC2 protein levels (SeqId = 18950-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAC2 protein levels (SeqId = 18950-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related C3 botulinum toxin substrate 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_rac2_protein_levels__seqid___18950-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZYX protein levels (SeqId = 13632-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZYX protein levels (SeqId = 13632-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zyxin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_zyx_protein_levels__seqid___13632-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SGK3 protein levels (SeqId = 10042-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SGK3 protein levels (SeqId = 10042-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase Sgk3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.589 0.139 0.000023 None Gadd-DA_sgk3_protein_levels__seqid___10042-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RRM2B protein levels (SeqId = 8925-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RRM2B protein levels (SeqId = 8925-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribonucleoside-diphosphate reductase subunit M2 B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_rrm2b_protein_levels__seqid___8925-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IRAK4 protein levels (SeqId = 18162-167) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IRAK4 protein levels (SeqId = 18162-167) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-1 receptor-associated kinase 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_irak4_protein_levels__seqid___18162-167__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSP90AB1 protein levels (SeqId = 5467-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSP90AB1 protein levels (SeqId = 5467-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock protein HSP 90-beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_hsp90ab1_protein_levels__seqid___5467-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NAA10 protein levels (SeqId = 17854-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAA10 protein levels (SeqId = 17854-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: N-alpha-acetyltransferase 10 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.588 0.139 0.000023 None Gadd-DA_naa10_protein_levels__seqid___17854-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARPP19 protein levels (SeqId = 4963-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARPP19 protein levels (SeqId = 4963-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: cAMP-regulated phosphoprotein 19 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_arpp19_protein_levels__seqid___4963-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AIF1 protein levels (SeqId = 2849-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AIF1 protein levels (SeqId = 2849-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Allograft inflammatory factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000023 None Gadd-DA_aif1_protein_levels__seqid___2849-49__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14084312 chr14:88459488 14 88459488 GALC Island 0.0021 0.00049 0.000023 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 KIT protein levels (SeqId = 2475-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIT protein levels (SeqId = 2475-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mast/stem cell growth factor receptor Kit 774 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore -0.64 0.15 0.000023 None Gadd-DA_kit_protein_levels__seqid___2475-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0349369 0.00825153 0.00002309744 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0349361 0.00825153 0.00002310776 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0541899 0.0128006 0.00002315898 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.0349031 0.00825154 0.00002352267 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0348993 0.00825154 0.00002357016 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0348857 0.00825155 0.00002374423 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PDIA6 protein levels (SeqId = 5650-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDIA6 protein levels (SeqId = 5650-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase A6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_pdia6_protein_levels__seqid___5650-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSPC159 protein levels (SeqId = 18236-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPC159 protein levels (SeqId = 18236-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galectin-related protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_hspc159_protein_levels__seqid___18236-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL9A1 protein levels (SeqId = 6631-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL9A1 protein levels (SeqId = 6631-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(IX) chain 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.586 0.139 0.000024 None Gadd-DA_col9a1_protein_levels__seqid___6631-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPKAPK2 protein levels (SeqId = 3820-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPKAPK2 protein levels (SeqId = 3820-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MAP kinase-activated protein kinase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_mapkapk2_protein_levels__seqid___3820-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL23A1 protein levels (SeqId = 4543-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL23A1 protein levels (SeqId = 4543-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(XXIII) chain 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000024 None Gadd-DA_col23a1_protein_levels__seqid___4543-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FLRT1 protein levels (SeqId = 4547-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FLRT1 protein levels (SeqId = 4547-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat transmembrane protein FLRT1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_flrt1_protein_levels__seqid___4547-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KLK15 protein levels (SeqId = 6491-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLK15 protein levels (SeqId = 6491-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kallikrein-15 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_klk15_protein_levels__seqid___6491-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2M protein levels (SeqId = 19111-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2M protein levels (SeqId = 19111-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NEDD8-conjugating enzyme Ubc12 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_ube2m_protein_levels__seqid___19111-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PABPC3 protein levels (SeqId = 10447-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PABPC3 protein levels (SeqId = 10447-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyadenylate-binding protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000024 None Gadd-DA_pabpc3_protein_levels__seqid___10447-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SH3GLB2 protein levels (SeqId = 18222-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH3GLB2 protein levels (SeqId = 18222-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endophilin-B2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000024 None Gadd-DA_sh3glb2_protein_levels__seqid___18222-34__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0348349 0.00825156 0.00002440229 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0380787 0.00902093 0.00002445232 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0348071 0.00825157 0.00002476924 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.034795 0.00825157 0.00002493097 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0544021 0.0129016 0.00002493963 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 UBE3A protein levels (SeqId = 11226-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE3A protein levels (SeqId = 11226-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-protein ligase E3A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000025 None Gadd-DA_ube3a_protein_levels__seqid___11226-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PGR protein levels (SeqId = 15693-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PGR protein levels (SeqId = 15693-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Progesterone receptor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000025 None Gadd-DA_pgr_protein_levels__seqid___15693-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COCH protein levels (SeqId = 7227-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COCH protein levels (SeqId = 7227-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cochlin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.137 0.000025 None Gadd-DA_coch_protein_levels__seqid___7227-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DKK2 protein levels (SeqId = 15678-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DKK2 protein levels (SeqId = 15678-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dickkopf-related protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000025 None Gadd-DA_dkk2_protein_levels__seqid___15678-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL2RG protein levels (SeqId = 2634-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL2RG protein levels (SeqId = 2634-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytokine receptor common subunit gamma 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000025 None Gadd-DA_il2rg_protein_levels__seqid___2634-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ELAVL1 protein levels (SeqId = 11592-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ELAVL1 protein levels (SeqId = 11592-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ELAV-like protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000025 None Gadd-DA_elavl1_protein_levels__seqid___11592-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HSP90B1 protein levels (SeqId = 6393-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSP90B1 protein levels (SeqId = 6393-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endoplasmin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000025 None Gadd-DA_hsp90b1_protein_levels__seqid___6393-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 WFDC13 protein levels (SeqId = 9345-436) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WFDC13 protein levels (SeqId = 9345-436) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: WAP four-disulfide core domain protein 13 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000025 None Gadd-DA_wfdc13_protein_levels__seqid___9345-436__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.034742 0.00825159 0.00002565069 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PARK2 protein levels (SeqId = 13013-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PARK2 protein levels (SeqId = 13013-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase parkin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000026 None Gadd-DA_park2_protein_levels__seqid___13013-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFHA1 protein levels (SeqId = 6226-69) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFHA1 protein levels (SeqId = 6226-69) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcium uptake protein 2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000026 None Gadd-DA_efha1_protein_levels__seqid___6226-69__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ROCK2 protein levels (SeqId = 13654-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ROCK2 protein levels (SeqId = 13654-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho-associated protein kinase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000026 None Gadd-DA_rock2_protein_levels__seqid___13654-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ST3GAL2 protein levels (SeqId = 6281-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST3GAL2 protein levels (SeqId = 6281-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000026 None Gadd-DA_st3gal2_protein_levels__seqid___6281-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SRC protein levels (SeqId = 15433-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SRC protein levels (SeqId = 15433-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proto-oncogene tyrosine-protein kinase Src 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000026 None Gadd-DA_src_protein_levels__seqid___15433-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DERL1 protein levels (SeqId = 13393-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DERL1 protein levels (SeqId = 13393-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Derlin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000026 None Gadd-DA_derl1_protein_levels__seqid___13393-46__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACADM protein levels (SeqId = 17333-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACADM protein levels (SeqId = 17333-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000026 None Gadd-DA_acadm_protein_levels__seqid___17333-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRDX1 protein levels (SeqId = 3855-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRDX1 protein levels (SeqId = 3855-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxiredoxin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000026 None Gadd-DA_prdx1_protein_levels__seqid___3855-56__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBQLN2 protein levels (SeqId = 19121-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBQLN2 protein levels (SeqId = 19121-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquilin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000026 None Gadd-DA_ubqln2_protein_levels__seqid___19121-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LGALS13 protein levels (SeqId = 19147-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LGALS13 protein levels (SeqId = 19147-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galactoside-binding soluble lectin 13 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000026 None Gadd-DA_lgals13_protein_levels__seqid___19147-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0346667 0.00825161 0.00002670705 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PNKP protein levels (SeqId = 13657-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PNKP protein levels (SeqId = 13657-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bifunctional polynucleotide phosphatase/kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_pnkp_protein_levels__seqid___13657-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BRD4 protein levels (SeqId = 10043-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BRD4 protein levels (SeqId = 10043-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bromodomain-containing protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.583 0.139 0.000027 None Gadd-DA_brd4_protein_levels__seqid___10043-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DBI protein levels (SeqId = 16919-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DBI protein levels (SeqId = 16919-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acyl-CoA-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.59 0.139 0.000027 None Gadd-DA_dbi_protein_levels__seqid___16919-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDC37 protein levels (SeqId = 3879-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDC37 protein levels (SeqId = 3879-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hsp90 co-chaperone Cdc37 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_cdc37_protein_levels__seqid___3879-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL20 protein levels (SeqId = 4138-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL20 protein levels (SeqId = 4138-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-20 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000027 None Gadd-DA_il20_protein_levels__seqid___4138-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TWF1 protein levels (SeqId = 12871-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TWF1 protein levels (SeqId = 12871-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Twinfilin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_twf1_protein_levels__seqid___12871-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SCARF1 protein levels (SeqId = 5129-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCARF1 protein levels (SeqId = 5129-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Scavenger receptor class F member 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_scarf1_protein_levels__seqid___5129-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DTD1 protein levels (SeqId = 19194-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DTD1 protein levels (SeqId = 19194-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: D-aminoacyl-tRNA deacylase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_dtd1_protein_levels__seqid___19194-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NDUFV2 protein levels (SeqId = 7748-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NDUFV2 protein levels (SeqId = 7748-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000027 None Gadd-DA_ndufv2_protein_levels__seqid___7748-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.0346196 0.00825162 0.00002738849 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17865849 chr14:88457175 14 88457175 GALC North shore 0.0346069 0.00825163 0.00002757427 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SH3GL2 protein levels (SeqId = 12499-108) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SH3GL2 protein levels (SeqId = 12499-108) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endophilin-A1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_sh3gl2_protein_levels__seqid___12499-108__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPN1 protein levels (SeqId = 10490-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPN1 protein levels (SeqId = 10490-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_rpn1_protein_levels__seqid___10490-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VEGFC protein levels (SeqId = 3132-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VEGFC protein levels (SeqId = 3132-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vascular endothelial growth factor C 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.583 0.139 0.000028 None Gadd-DA_vegfc_protein_levels__seqid___3132-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CTBP1 protein levels (SeqId = 11217-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTBP1 protein levels (SeqId = 11217-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-terminal-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_ctbp1_protein_levels__seqid___11217-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LRRC59 protein levels (SeqId = 19163-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRRC59 protein levels (SeqId = 19163-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat-containing protein 59 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_lrrc59_protein_levels__seqid___19163-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DKK1 protein levels (SeqId = 3535-84) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DKK1 protein levels (SeqId = 3535-84) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dickkopf-related protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000028 None Gadd-DA_dkk1_protein_levels__seqid___3535-84__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDK1 protein levels (SeqId = 5227-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDK1 protein levels (SeqId = 5227-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_pdk1_protein_levels__seqid___5227-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITGA2B protein levels (SeqId = 19574-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITGA2B protein levels (SeqId = 19574-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integrin alpha-IIb|Integrin beta-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_itga2b_protein_levels__seqid___19574-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SSU72 protein levels (SeqId = 13566-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SSU72 protein levels (SeqId = 13566-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_ssu72_protein_levels__seqid___13566-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STUB1 protein levels (SeqId = 11350-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STUB1 protein levels (SeqId = 11350-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase CHIP 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_stub1_protein_levels__seqid___11350-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CYTH4 protein levels (SeqId = 12746-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CYTH4 protein levels (SeqId = 12746-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytohesin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000028 None Gadd-DA_cyth4_protein_levels__seqid___12746-4__somascan_protein_measurement Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0005 0.00012 0.000028 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Gadd DA Generation Scotland 35945220 31/07/2022 ARHGAP25 protein levels (SeqId = 11333-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGAP25 protein levels (SeqId = 11333-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho GTPase-activating protein 25 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000029 None Gadd-DA_arhgap25_protein_levels__seqid___11333-82__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPTLC1 protein levels (SeqId = 7886-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPTLC1 protein levels (SeqId = 7886-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine palmitoyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.000029 None Gadd-DA_sptlc1_protein_levels__seqid___7886-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPL12 protein levels (SeqId = 19183-164) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPL12 protein levels (SeqId = 19183-164) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 60S ribosomal protein L12 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000029 None Gadd-DA_rpl12_protein_levels__seqid___19183-164__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDC42BPB protein levels (SeqId = 3629-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDC42BPB protein levels (SeqId = 3629-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase MRCK beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000029 None Gadd-DA_cdc42bpb_protein_levels__seqid___3629-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LYZL2 protein levels (SeqId = 6377-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LYZL2 protein levels (SeqId = 6377-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysozyme-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000029 None Gadd-DA_lyzl2_protein_levels__seqid___6377-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2I protein levels (SeqId = 2877-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2I protein levels (SeqId = 2877-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SUMO-conjugating enzyme UBC9 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000029 None Gadd-DA_ube2i_protein_levels__seqid___2877-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0344636 0.00825167 0.00002976555 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Cardenas A Project Viva 31300640 Jul 12, 2019 allergic asthma MONDO_0004784 None Supplementary Data 3 DNA methylation allergic asthma Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values None Illumina HumanMethylationEPIC nasal epithelium None 277 1 Children Both Other cg04738877 chr14:88459963 14 88459963 GALC South shore -2.29 0.54 0.00003 SE manually calculated 31300640_Cardenas-A_allergic_asthma Gadd DA Generation Scotland 35945220 31/07/2022 TTC1 protein levels (SeqId = 9864-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC1 protein levels (SeqId = 9864-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_ttc1_protein_levels__seqid___9864-38__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 G3BP1 protein levels (SeqId = 19266-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 G3BP1 protein levels (SeqId = 19266-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras GTPase-activating protein-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_g3bp1_protein_levels__seqid___19266-35__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNTA1 protein levels (SeqId = 19274-80) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNTA1 protein levels (SeqId = 19274-80) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1-syntrophin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_snta1_protein_levels__seqid___19274-80__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSMD1 protein levels (SeqId = 9598-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSMD1 protein levels (SeqId = 9598-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CUB and sushi domain-containing protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_csmd1_protein_levels__seqid___9598-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDT2 protein levels (SeqId = 16583-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDT2 protein levels (SeqId = 16583-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_nudt2_protein_levels__seqid___16583-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDLBP protein levels (SeqId = 13570-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDLBP protein levels (SeqId = 13570-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vigilin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.138 0.00003 None Gadd-DA_hdlbp_protein_levels__seqid___13570-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PAFAH1B2 protein levels (SeqId = 2642-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAFAH1B2 protein levels (SeqId = 2642-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet-activating factor acetylhydrolase IB subunit beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_pafah1b2_protein_levels__seqid___2642-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PKN1 protein levels (SeqId = 12562-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PKN1 protein levels (SeqId = 12562-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase N1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.00003 None Gadd-DA_pkn1_protein_levels__seqid___12562-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PARK7 protein levels (SeqId = 19523-215) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PARK7 protein levels (SeqId = 19523-215) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein/nucleic acid deglycase DJ-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000031 None Gadd-DA_park7_protein_levels__seqid___19523-215__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PKM2 protein levels (SeqId = 4240-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PKM2 protein levels (SeqId = 4240-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyruvate kinase PKM 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000031 None Gadd-DA_pkm2_protein_levels__seqid___4240-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 USP8 protein levels (SeqId = 13450-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 USP8 protein levels (SeqId = 13450-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin carboxyl-terminal hydrolase 8 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000031 None Gadd-DA_usp8_protein_levels__seqid___13450-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCL27 protein levels (SeqId = 2192-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCL27 protein levels (SeqId = 2192-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-C motif chemokine 27 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000031 None Gadd-DA_ccl27_protein_levels__seqid___2192-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DGCR14 protein levels (SeqId = 11356-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DGCR14 protein levels (SeqId = 11356-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Splicing factor ESS-2 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000031 None Gadd-DA_dgcr14_protein_levels__seqid___11356-19__somascan_protein_measurement Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0649872 0.0156217 0.00003181 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0343317 0.0082517 0.00003192753 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0464983 0.0111764 0.00003194857 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.212758 0.0511436 0.00003197666 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC16 protein levels (SeqId = 10454-99) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC16 protein levels (SeqId = 10454-99) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 16 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_dnajc16_protein_levels__seqid___10454-99__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PECR protein levels (SeqId = 17776-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PECR protein levels (SeqId = 17776-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxisomal trans-2-enoyl-CoA reductase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_pecr_protein_levels__seqid___17776-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APRT protein levels (SeqId = 10088-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APRT protein levels (SeqId = 10088-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenine phosphoribosyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_aprt_protein_levels__seqid___10088-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MED4 protein levels (SeqId = 14021-81) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MED4 protein levels (SeqId = 14021-81) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mediator of RNA polymerase II transcription subunit 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.14 0.000032 None Gadd-DA_med4_protein_levels__seqid___14021-81__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNTB1 protein levels (SeqId = 9078-207) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNTB1 protein levels (SeqId = 9078-207) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1-syntrophin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_sntb1_protein_levels__seqid___9078-207__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PACSIN1 protein levels (SeqId = 12676-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PACSIN1 protein levels (SeqId = 12676-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein kinase C and casein kinase substrate in neurons protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_pacsin1_protein_levels__seqid___12676-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PURB protein levels (SeqId = 18300-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PURB protein levels (SeqId = 18300-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcriptional activator protein Pur-beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_purb_protein_levels__seqid___18300-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CBX3 protein levels (SeqId = 18868-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBX3 protein levels (SeqId = 18868-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chromobox protein homolog 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_cbx3_protein_levels__seqid___18868-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSMD2 protein levels (SeqId = 9971-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSMD2 protein levels (SeqId = 9971-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CUB and sushi domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_csmd2_protein_levels__seqid___9971-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PGLS protein levels (SeqId = 17799-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PGLS protein levels (SeqId = 17799-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 6-phosphogluconolactonase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000032 None Gadd-DA_pgls_protein_levels__seqid___17799-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.78 0.188 0.000032 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0459997 0.0110623 0.0000322554 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0817394 0.0196777 0.00003286932 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore -0.0342708 0.00825172 0.00003297532 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 DAPK1 protein levels (SeqId = 13955-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DAPK1 protein levels (SeqId = 13955-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Death-associated protein kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.576 0.139 0.000033 None Gadd-DA_dapk1_protein_levels__seqid___13955-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TRIP10 protein levels (SeqId = 17676-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TRIP10 protein levels (SeqId = 17676-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cdc42-interacting protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_trip10_protein_levels__seqid___17676-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PCNP protein levels (SeqId = 17769-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PCNP protein levels (SeqId = 17769-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PEST proteolytic signal-containing nuclear protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_pcnp_protein_levels__seqid___17769-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDIA3 protein levels (SeqId = 4719-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDIA3 protein levels (SeqId = 4719-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase A3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_pdia3_protein_levels__seqid___4719-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AREG protein levels (SeqId = 2970-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AREG protein levels (SeqId = 2970-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Amphiregulin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_areg_protein_levels__seqid___2970-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AGO3 protein levels (SeqId = 15323-112) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGO3 protein levels (SeqId = 15323-112) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein argonaute-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_ago3_protein_levels__seqid___15323-112__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TARS protein levels (SeqId = 18186-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TARS protein levels (SeqId = 18186-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Threonine--tRNA ligase, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_tars_protein_levels__seqid___18186-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TESC protein levels (SeqId = 12831-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TESC protein levels (SeqId = 12831-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calcineurin B homologous protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000033 None Gadd-DA_tesc_protein_levels__seqid___12831-21__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25377313 chr14:88456098 14 88456098 GALC North shelf -0.262614 0.063264 0.00003323999 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0342217 0.00825174 0.00003384412 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FER protein levels (SeqId = 4220-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FER protein levels (SeqId = 4220-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tyrosine-protein kinase Fer 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_fer_protein_levels__seqid___4220-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRB2 protein levels (SeqId = 5464-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRB2 protein levels (SeqId = 5464-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth factor receptor-bound protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_grb2_protein_levels__seqid___5464-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SDF2L1 protein levels (SeqId = 6990-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SDF2L1 protein levels (SeqId = 6990-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stromal cell-derived factor 2-like protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_sdf2l1_protein_levels__seqid___6990-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSME1 protein levels (SeqId = 5918-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSME1 protein levels (SeqId = 5918-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome activator complex subunit 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_psme1_protein_levels__seqid___5918-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF16 protein levels (SeqId = 4393-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF16 protein levels (SeqId = 4393-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 16 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_fgf16_protein_levels__seqid___4393-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FKBP4 protein levels (SeqId = 17722-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FKBP4 protein levels (SeqId = 17722-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_fkbp4_protein_levels__seqid___17722-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GMFG protein levels (SeqId = 13062-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GMFG protein levels (SeqId = 13062-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glia maturation factor gamma 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000034 None Gadd-DA_gmfg_protein_levels__seqid___13062-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore -0.0341996 0.00825174 0.00003424226 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0341786 0.00825175 0.00003462503 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HSPB1 protein levels (SeqId = 11103-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPB1 protein levels (SeqId = 11103-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock protein beta-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.574 0.139 0.000035 None Gadd-DA_hspb1_protein_levels__seqid___11103-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DLX3 protein levels (SeqId = 11422-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DLX3 protein levels (SeqId = 11422-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homeobox protein DLX-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000035 None Gadd-DA_dlx3_protein_levels__seqid___11422-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UGT1A1 protein levels (SeqId = 17702-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UGT1A1 protein levels (SeqId = 17702-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UDP-glucuronosyltransferase 1-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000035 None Gadd-DA_ugt1a1_protein_levels__seqid___17702-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKCQ protein levels (SeqId = 3817-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKCQ protein levels (SeqId = 3817-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein kinase C theta type 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000035 None Gadd-DA_prkcq_protein_levels__seqid___3817-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNAI3 protein levels (SeqId = 12650-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNAI3 protein levels (SeqId = 12650-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide-binding protein G(k) subunit alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.14 0.000035 None Gadd-DA_gnai3_protein_levels__seqid___12650-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPRE2 protein levels (SeqId = 16856-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPRE2 protein levels (SeqId = 16856-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Microtubule-associated protein RP/EB family member 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000035 None Gadd-DA_mapre2_protein_levels__seqid___16856-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRVI1 protein levels (SeqId = 8255-34) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRVI1 protein levels (SeqId = 8255-34) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein MRVI1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000035 None Gadd-DA_mrvi1_protein_levels__seqid___8255-34__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF114 protein levels (SeqId = 9957-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF114 protein levels (SeqId = 9957-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RNF114 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000035 None Gadd-DA_rnf114_protein_levels__seqid___9957-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARPC3 protein levels (SeqId = 13573-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARPC3 protein levels (SeqId = 13573-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Actin-related protein 2/3 complex subunit 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000035 None Gadd-DA_arpc3_protein_levels__seqid___13573-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0358495 0.00867295 0.00003592864 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 NME2 protein levels (SeqId = 4249-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NME2 protein levels (SeqId = 4249-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nucleoside diphosphate kinase B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000036 None Gadd-DA_nme2_protein_levels__seqid___4249-64__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CETN2 protein levels (SeqId = 13078-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CETN2 protein levels (SeqId = 13078-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Centrin-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.58 0.139 0.000036 None Gadd-DA_cetn2_protein_levels__seqid___13078-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VAV1 protein levels (SeqId = 5275-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VAV1 protein levels (SeqId = 5275-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proto-oncogene vav 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000036 None Gadd-DA_vav1_protein_levels__seqid___5275-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDXP protein levels (SeqId = 3897-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDXP protein levels (SeqId = 3897-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyridoxal phosphate phosphatase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000036 None Gadd-DA_pdxp_protein_levels__seqid___3897-61__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22748363 chr14:88459682 14 88459682 GALC Island 0.034095 0.00825177 0.00003618589 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0409288 0.00991517 0.00003681268 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.88 0.214 0.000037 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKCA protein levels (SeqId = 2644-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKCA protein levels (SeqId = 2644-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein kinase C alpha type 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_prkca_protein_levels__seqid___2644-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPIE protein levels (SeqId = 5238-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIE protein levels (SeqId = 5238-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase E 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_ppie_protein_levels__seqid___5238-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDXK protein levels (SeqId = 11098-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDXK protein levels (SeqId = 11098-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyridoxal kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_pdxk_protein_levels__seqid___11098-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LCMT1 protein levels (SeqId = 4237-70) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LCMT1 protein levels (SeqId = 4237-70) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine carboxyl methyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_lcmt1_protein_levels__seqid___4237-70__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GSK3A protein levels (SeqId = 3441-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSK3A protein levels (SeqId = 3441-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycogen synthase kinase-3 alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_gsk3a_protein_levels__seqid___3441-64__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FAM175B protein levels (SeqId = 8945-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAM175B protein levels (SeqId = 8945-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BRISC complex subunit Abraxas 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000037 None Gadd-DA_fam175b_protein_levels__seqid___8945-7__somascan_protein_measurement Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26245531 chr14:88459216 14 88459216 GALC Island 0.00458 0.00108 0.000037 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0382872 0.00928879 0.00003778832 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 STAT1 protein levels (SeqId = 10370-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAT1 protein levels (SeqId = 10370-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal transducer and activator of transcription 1-alpha/beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_stat1_protein_levels__seqid___10370-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NUDT9 protein levels (SeqId = 9482-110) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NUDT9 protein levels (SeqId = 9482-110) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribose pyrophosphatase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_nudt9_protein_levels__seqid___9482-110__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HMG20B protein levels (SeqId = 11551-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMG20B protein levels (SeqId = 11551-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_hmg20b_protein_levels__seqid___11551-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPIF protein levels (SeqId = 5248-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIF protein levels (SeqId = 5248-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_ppif_protein_levels__seqid___5248-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GGA1 protein levels (SeqId = 13594-158) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GGA1 protein levels (SeqId = 13594-158) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-binding protein GGA1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_gga1_protein_levels__seqid___13594-158__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AGO1 protein levels (SeqId = 15312-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGO1 protein levels (SeqId = 15312-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein argonaute-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_ago1_protein_levels__seqid___15312-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXNDC5 protein levels (SeqId = 11212-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNDC5 protein levels (SeqId = 11212-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin domain-containing protein 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.574 0.139 0.000038 None Gadd-DA_txndc5_protein_levels__seqid___11212-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AASDHPPT protein levels (SeqId = 17320-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AASDHPPT protein levels (SeqId = 17320-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_aasdhppt_protein_levels__seqid___17320-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ERP44 protein levels (SeqId = 6064-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERP44 protein levels (SeqId = 6064-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endoplasmic reticulum resident protein 44 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_erp44_protein_levels__seqid___6064-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LECT1 protein levels (SeqId = 9928-125) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LECT1 protein levels (SeqId = 9928-125) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte cell-derived chemotaxin 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000038 None Gadd-DA_lect1_protein_levels__seqid___9928-125__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0339604 0.00825181 0.00003884291 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ZNF41 protein levels (SeqId = 10003-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF41 protein levels (SeqId = 10003-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 41 774 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore -0.68 0.165 0.000039 None Gadd-DA_znf41_protein_levels__seqid___10003-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TYK2 protein levels (SeqId = 5260-80) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TYK2 protein levels (SeqId = 5260-80) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Non-receptor tyrosine-protein kinase TYK2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_tyk2_protein_levels__seqid___5260-80__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANXA4 protein levels (SeqId = 17164-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANXA4 protein levels (SeqId = 17164-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Annexin A4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_anxa4_protein_levels__seqid___17164-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXNL4B protein levels (SeqId = 15316-262) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNL4B protein levels (SeqId = 15316-262) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin-like protein 4B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_txnl4b_protein_levels__seqid___15316-262__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDYN protein levels (SeqId = 19638-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDYN protein levels (SeqId = 19638-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proenkephalin-B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000039 None Gadd-DA_pdyn_protein_levels__seqid___19638-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPK1 protein levels (SeqId = 3115-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPK1 protein levels (SeqId = 3115-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitogen-activated protein kinase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_mapk1_protein_levels__seqid___3115-64__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GDI2 protein levels (SeqId = 2647-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDI2 protein levels (SeqId = 2647-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rab GDP dissociation inhibitor beta 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_gdi2_protein_levels__seqid___2647-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDRG1 protein levels (SeqId = 12593-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDRG1 protein levels (SeqId = 12593-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: p53 and DNA damage-regulated protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_pdrg1_protein_levels__seqid___12593-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DYNLL2 protein levels (SeqId = 11493-169) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DYNLL2 protein levels (SeqId = 11493-169) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dynein light chain 2, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_dynll2_protein_levels__seqid___11493-169__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DPP7 protein levels (SeqId = 8346-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DPP7 protein levels (SeqId = 8346-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dipeptidyl peptidase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_dpp7_protein_levels__seqid___8346-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDE5A protein levels (SeqId = 16805-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDE5A protein levels (SeqId = 16805-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: cGMP-specific 3',5'-cyclic phosphodiesterase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000039 None Gadd-DA_pde5a_protein_levels__seqid___16805-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0407566 0.00990876 0.00003923532 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPDL protein levels (SeqId = 10852-114) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPDL protein levels (SeqId = 10852-114) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein D-like 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.00004 None Gadd-DA_hnrnpdl_protein_levels__seqid___10852-114__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ULBP2 protein levels (SeqId = 3082-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ULBP2 protein levels (SeqId = 3082-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UL16-binding protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.00004 None Gadd-DA_ulbp2_protein_levels__seqid___3082-9__somascan_protein_measurement Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg24058132 chr14:88459866 14 88459866 GALC South shore -0.00342 0.00083 0.00004 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 ALKBH3 protein levels (SeqId = 18401-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALKBH3 protein levels (SeqId = 18401-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_alkbh3_protein_levels__seqid___18401-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NSF protein levels (SeqId = 13992-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NSF protein levels (SeqId = 13992-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vesicle-fusing ATPase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_nsf_protein_levels__seqid___13992-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPKAPK3 protein levels (SeqId = 3822-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPKAPK3 protein levels (SeqId = 3822-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MAP kinase-activated protein kinase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_mapkapk3_protein_levels__seqid___3822-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DDR1 protein levels (SeqId = 4122-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DDR1 protein levels (SeqId = 4122-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Epithelial discoidin domain-containing receptor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000041 None Gadd-DA_ddr1_protein_levels__seqid___4122-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KPNA4 protein levels (SeqId = 12698-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KPNA4 protein levels (SeqId = 12698-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Importin subunit alpha-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000041 None Gadd-DA_kpna4_protein_levels__seqid___12698-72__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GOT1 protein levels (SeqId = 4912-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GOT1 protein levels (SeqId = 4912-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aspartate aminotransferase, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_got1_protein_levels__seqid___4912-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IRF3 protein levels (SeqId = 17151-84) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IRF3 protein levels (SeqId = 17151-84) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon regulatory factor 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_irf3_protein_levels__seqid___17151-84__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBM17 protein levels (SeqId = 17391-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBM17 protein levels (SeqId = 17391-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Splicing factor 45 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_rbm17_protein_levels__seqid___17391-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNFAIP8 protein levels (SeqId = 12563-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFAIP8 protein levels (SeqId = 12563-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor alpha-induced protein 8 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000041 None Gadd-DA_tnfaip8_protein_levels__seqid___12563-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0338439 0.00825184 0.00004129163 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 STX4 protein levels (SeqId = 10668-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STX4 protein levels (SeqId = 10668-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Syntaxin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000042 None Gadd-DA_stx4_protein_levels__seqid___10668-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ING1 protein levels (SeqId = 3888-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ING1 protein levels (SeqId = 3888-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inhibitor of growth protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000042 None Gadd-DA_ing1_protein_levels__seqid___3888-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PARVA protein levels (SeqId = 13434-172) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PARVA protein levels (SeqId = 13434-172) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-parvin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000042 None Gadd-DA_parva_protein_levels__seqid___13434-172__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANXA1 protein levels (SeqId = 4960-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANXA1 protein levels (SeqId = 4960-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Annexin A1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000042 None Gadd-DA_anxa1_protein_levels__seqid___4960-72__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0460284 0.0112343 0.00004205663 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0463003 0.0113009 0.00004207181 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 HOMER2 protein levels (SeqId = 12685-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HOMER2 protein levels (SeqId = 12685-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homer protein homolog 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.564 0.138 0.000043 None Gadd-DA_homer2_protein_levels__seqid___12685-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRPSAP2 protein levels (SeqId = 19150-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRPSAP2 protein levels (SeqId = 19150-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoribosyl pyrophosphate synthase-associated protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000043 None Gadd-DA_prpsap2_protein_levels__seqid___19150-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMED2 protein levels (SeqId = 10761-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMED2 protein levels (SeqId = 10761-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane emp24 domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000043 None Gadd-DA_tmed2_protein_levels__seqid___10761-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BTNL8 protein levels (SeqId = 9026-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BTNL8 protein levels (SeqId = 9026-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Butyrophilin-like protein 8 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000043 None Gadd-DA_btnl8_protein_levels__seqid___9026-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FIS1 protein levels (SeqId = 17746-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FIS1 protein levels (SeqId = 17746-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitochondrial fission 1 protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000043 None Gadd-DA_fis1_protein_levels__seqid___17746-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TK2 protein levels (SeqId = 19114-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TK2 protein levels (SeqId = 19114-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thymidine kinase 2, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000044 None Gadd-DA_tk2_protein_levels__seqid___19114-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NPL protein levels (SeqId = 19496-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPL protein levels (SeqId = 19496-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: N-acetylneuraminate lyase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000044 None Gadd-DA_npl_protein_levels__seqid___19496-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HGS protein levels (SeqId = 13644-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HGS protein levels (SeqId = 13644-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hepatocyte growth factor-regulated tyrosine kinase substrate 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000044 None Gadd-DA_hgs_protein_levels__seqid___13644-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FKBP2 protein levels (SeqId = 9339-204) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FKBP2 protein levels (SeqId = 9339-204) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000044 None Gadd-DA_fkbp2_protein_levels__seqid___9339-204__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TOR1AIP2 protein levels (SeqId = 10553-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TOR1AIP2 protein levels (SeqId = 10553-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Torsin-1A-interacting protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.138 0.000044 None Gadd-DA_tor1aip2_protein_levels__seqid___10553-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CEL protein levels (SeqId = 9796-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CEL protein levels (SeqId = 9796-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bile salt-activated lipase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000044 None Gadd-DA_cel_protein_levels__seqid___9796-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.0349638 0.00855757 0.00004417551 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 POGLUT1 protein levels (SeqId = 6467-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POGLUT1 protein levels (SeqId = 6467-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein O-glucosyltransferase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_poglut1_protein_levels__seqid___6467-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPM1D protein levels (SeqId = 11315-148) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPM1D protein levels (SeqId = 11315-148) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein phosphatase 1D 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_ppm1d_protein_levels__seqid___11315-148__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 OVCA2 protein levels (SeqId = 17697-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OVCA2 protein levels (SeqId = 17697-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Esterase OVCA2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_ovca2_protein_levels__seqid___17697-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APBB3 protein levels (SeqId = 13589-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APBB3 protein levels (SeqId = 13589-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_apbb3_protein_levels__seqid___13589-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EIF5A protein levels (SeqId = 5888-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EIF5A protein levels (SeqId = 5888-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Eukaryotic translation initiation factor 5A-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_eif5a_protein_levels__seqid___5888-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VPS24 protein levels (SeqId = 12508-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VPS24 protein levels (SeqId = 12508-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Charged multivesicular body protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000045 None Gadd-DA_vps24_protein_levels__seqid___12508-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.045945 0.0112663 0.00004564405 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 EPB41 protein levels (SeqId = 4706-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EPB41 protein levels (SeqId = 4706-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein 4.1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000046 None Gadd-DA_epb41_protein_levels__seqid___4706-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXNRD1 protein levels (SeqId = 13967-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNRD1 protein levels (SeqId = 13967-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin reductase 1, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000046 None Gadd-DA_txnrd1_protein_levels__seqid___13967-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 THRA protein levels (SeqId = 12527-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 THRA protein levels (SeqId = 12527-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thyroid hormone receptor alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000046 None Gadd-DA_thra_protein_levels__seqid___12527-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PNP protein levels (SeqId = 15435-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PNP protein levels (SeqId = 15435-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Purine nucleoside phosphorylase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000046 None Gadd-DA_pnp_protein_levels__seqid___15435-4__somascan_protein_measurement Cardenas A Project Viva 31300640 Jul 12, 2019 allergic asthma MONDO_0004784 None Supplementary Data 3 DNA methylation allergic asthma Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values None Illumina HumanMethylationEPIC nasal epithelium None 277 1 Children Both Other cg18322600 chr14:88455060 14 88455060 GALC Open sea -2.79 0.674 0.000046 SE manually calculated 31300640_Cardenas-A_allergic_asthma Gadd DA Generation Scotland 35945220 31/07/2022 POLR2K protein levels (SeqId = 19134-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POLR2K protein levels (SeqId = 19134-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA-directed RNA polymerases I, II, and III subunit RPABC4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000047 None Gadd-DA_polr2k_protein_levels__seqid___19134-66__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLIC4 protein levels (SeqId = 15314-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLIC4 protein levels (SeqId = 15314-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chloride intracellular channel protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000047 None Gadd-DA_clic4_protein_levels__seqid___15314-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KARS protein levels (SeqId = 19249-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KARS protein levels (SeqId = 19249-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysine--tRNA ligase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000047 None Gadd-DA_kars_protein_levels__seqid___19249-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GGPS1 protein levels (SeqId = 17786-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GGPS1 protein levels (SeqId = 17786-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Geranylgeranyl pyrophosphate synthase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.566 0.139 0.000047 None Gadd-DA_ggps1_protein_levels__seqid___17786-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CAND1 protein levels (SeqId = 13937-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CAND1 protein levels (SeqId = 13937-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cullin-associated NEDD8-dissociated protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000047 None Gadd-DA_cand1_protein_levels__seqid___13937-75__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0335579 0.00825192 0.00004793769 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 POLE3 protein levels (SeqId = 19170-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POLE3 protein levels (SeqId = 19170-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA polymerase epsilon subunit 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000048 None Gadd-DA_pole3_protein_levels__seqid___19170-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SIAE protein levels (SeqId = 9263-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIAE protein levels (SeqId = 9263-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialate O-acetylesterase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000048 None Gadd-DA_siae_protein_levels__seqid___9263-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EXOSC8 protein levels (SeqId = 18909-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EXOSC8 protein levels (SeqId = 18909-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Exosome complex component RRP43 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.000048 None Gadd-DA_exosc8_protein_levels__seqid___18909-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLAMF7 protein levels (SeqId = 5487-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLAMF7 protein levels (SeqId = 5487-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SLAM family member 7 774 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.69 0.169 0.000048 None Gadd-DA_slamf7_protein_levels__seqid___5487-7__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.027 0.00654 0.000048 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.046367 0.0114039 0.00004809723 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CTGF protein levels (SeqId = 2975-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTGF protein levels (SeqId = 2975-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Connective tissue growth factor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000049 None Gadd-DA_ctgf_protein_levels__seqid___2975-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CLINT1 protein levels (SeqId = 11659-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLINT1 protein levels (SeqId = 11659-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Clathrin interactor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000049 None Gadd-DA_clint1_protein_levels__seqid___11659-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAP2K2 protein levels (SeqId = 3628-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAP2K2 protein levels (SeqId = 3628-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.00005 None Gadd-DA_map2k2_protein_levels__seqid___3628-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCL2L2 protein levels (SeqId = 13097-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCL2L2 protein levels (SeqId = 13097-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bcl-2-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.563 0.139 0.00005 None Gadd-DA_bcl2l2_protein_levels__seqid___13097-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GGA3 protein levels (SeqId = 11683-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GGA3 protein levels (SeqId = 11683-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-binding protein GGA3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.00005 None Gadd-DA_gga3_protein_levels__seqid___11683-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VRK1 protein levels (SeqId = 12553-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VRK1 protein levels (SeqId = 12553-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase VRK1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.00005 None Gadd-DA_vrk1_protein_levels__seqid___12553-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CSH1 protein levels (SeqId = 13103-125) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSH1 protein levels (SeqId = 13103-125) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chorionic somatomammotropin hormone 2|Chorionic somatomammotropin hormone 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.57 0.139 0.00005 None Gadd-DA_csh1_protein_levels__seqid___13103-125__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0450836 0.0111207 0.0000506069 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ISCU protein levels (SeqId = 7201-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ISCU protein levels (SeqId = 7201-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000051 None Gadd-DA_iscu_protein_levels__seqid___7201-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RIPPLY1 protein levels (SeqId = 9767-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RIPPLY1 protein levels (SeqId = 9767-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein ripply1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000051 None Gadd-DA_ripply1_protein_levels__seqid___9767-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MDM1 protein levels (SeqId = 7898-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MDM1 protein levels (SeqId = 7898-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear protein MDM1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.565 0.139 0.000051 None Gadd-DA_mdm1_protein_levels__seqid___7898-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH1A3 protein levels (SeqId = 9835-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH1A3 protein levels (SeqId = 9835-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldehyde dehydrogenase family 1 member A3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000051 None Gadd-DA_aldh1a3_protein_levels__seqid___9835-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HPRT1 protein levels (SeqId = 19290-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HPRT1 protein levels (SeqId = 19290-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hypoxanthine-guanine phosphoribosyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000051 None Gadd-DA_hprt1_protein_levels__seqid___19290-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea 0.0334262 0.00825196 0.00005132675 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore 0.0334233 0.00825196 0.00005140557 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05956531 chr14:88407098 14 88407098 GALC Open sea 0.033402 0.00825196 0.00005197467 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ARHGDIB protein levels (SeqId = 9846-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGDIB protein levels (SeqId = 9846-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho GDP-dissociation inhibitor 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000052 None Gadd-DA_arhgdib_protein_levels__seqid___9846-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AGAP2 protein levels (SeqId = 14291-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGAP2 protein levels (SeqId = 14291-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000052 None Gadd-DA_agap2_protein_levels__seqid___14291-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IMPDH2 protein levels (SeqId = 5250-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IMPDH2 protein levels (SeqId = 5250-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inosine-5'-monophosphate dehydrogenase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000052 None Gadd-DA_impdh2_protein_levels__seqid___5250-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore -0.0356674 0.00881775 0.00005260161 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 DENR protein levels (SeqId = 19287-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DENR protein levels (SeqId = 19287-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Density-regulated protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000053 None Gadd-DA_denr_protein_levels__seqid___19287-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BTC protein levels (SeqId = 13088-397) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BTC protein levels (SeqId = 13088-397) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probetacellulin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000053 None Gadd-DA_btc_protein_levels__seqid___13088-397__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AHSA1 protein levels (SeqId = 11633-89) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AHSA1 protein levels (SeqId = 11633-89) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activator of 90 kDa heat shock protein ATPase homolog 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000053 None Gadd-DA_ahsa1_protein_levels__seqid___11633-89__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PURA protein levels (SeqId = 12537-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PURA protein levels (SeqId = 12537-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcriptional activator protein Pur-alpha 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000053 None Gadd-DA_pura_protein_levels__seqid___12537-88__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0333538 0.00825198 0.00005328635 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21274300 chr14:88459745 14 88459745 GALC South shore 0.140633 0.0347967 0.00005332961 None 39706196_Hannah-M.-Smith_bmi_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 RBBP6 protein levels (SeqId = 9887-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBBP6 protein levels (SeqId = 9887-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RBBP6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000054 None Gadd-DA_rbbp6_protein_levels__seqid___9887-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFNB1 protein levels (SeqId = 13104-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFNB1 protein levels (SeqId = 13104-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ephrin-B1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000054 None Gadd-DA_efnb1_protein_levels__seqid___13104-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COMMD7 protein levels (SeqId = 2823-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COMMD7 protein levels (SeqId = 2823-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: COMM domain-containing protein 7 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000054 None Gadd-DA_commd7_protein_levels__seqid___2823-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B3GALTL protein levels (SeqId = 5727-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B3GALTL protein levels (SeqId = 5727-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,3-glucosyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000054 None Gadd-DA_b3galtl_protein_levels__seqid___5727-35__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDGFD protein levels (SeqId = 17140-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDGFD protein levels (SeqId = 17140-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet-derived growth factor D 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000054 None Gadd-DA_pdgfd_protein_levels__seqid___17140-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARHGAP1 protein levels (SeqId = 11955-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARHGAP1 protein levels (SeqId = 11955-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rho GTPase-activating protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000055 None Gadd-DA_arhgap1_protein_levels__seqid___11955-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MTHFD1 protein levels (SeqId = 12575-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTHFD1 protein levels (SeqId = 12575-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-1-tetrahydrofolate synthase, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_mthfd1_protein_levels__seqid___12575-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAC1 protein levels (SeqId = 2870-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAC1 protein levels (SeqId = 2870-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related C3 botulinum toxin substrate 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_rac1_protein_levels__seqid___2870-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARF1 protein levels (SeqId = 19239-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARF1 protein levels (SeqId = 19239-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_arf1_protein_levels__seqid___19239-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL6 protein levels (SeqId = 4673-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL6 protein levels (SeqId = 4673-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_il6_protein_levels__seqid___4673-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MARK3 protein levels (SeqId = 9747-48) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MARK3 protein levels (SeqId = 9747-48) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MAP/microtubule affinity-regulating kinase 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_mark3_protein_levels__seqid___9747-48__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EZR protein levels (SeqId = 9753-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EZR protein levels (SeqId = 9753-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ezrin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_ezr_protein_levels__seqid___9753-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TOLLIP protein levels (SeqId = 13963-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TOLLIP protein levels (SeqId = 13963-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Toll-interacting protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_tollip_protein_levels__seqid___13963-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LST1 protein levels (SeqId = 9531-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LST1 protein levels (SeqId = 9531-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte-specific transcript 1 protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_lst1_protein_levels__seqid___9531-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DTD2 protein levels (SeqId = 18280-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DTD2 protein levels (SeqId = 18280-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: D-aminoacyl-tRNA deacylase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000056 None Gadd-DA_dtd2_protein_levels__seqid___18280-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05956531 chr14:88407098 14 88407098 GALC Open sea -0.0332378 0.00825201 0.00005657536 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 UBASH3B protein levels (SeqId = 12558-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBASH3B protein levels (SeqId = 12558-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-associated and SH3 domain-containing protein B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000057 None Gadd-DA_ubash3b_protein_levels__seqid___12558-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 WWOX protein levels (SeqId = 17724-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WWOX protein levels (SeqId = 17724-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: WW domain-containing oxidoreductase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000058 None Gadd-DA_wwox_protein_levels__seqid___17724-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPRE1 protein levels (SeqId = 12469-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPRE1 protein levels (SeqId = 12469-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Microtubule-associated protein RP/EB family member 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000058 None Gadd-DA_mapre1_protein_levels__seqid___12469-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TREML1 protein levels (SeqId = 11147-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TREML1 protein levels (SeqId = 11147-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trem-like transcript 1 protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000058 None Gadd-DA_treml1_protein_levels__seqid___11147-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CIRBP protein levels (SeqId = 12724-81) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CIRBP protein levels (SeqId = 12724-81) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cold-inducible RNA-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000058 None Gadd-DA_cirbp_protein_levels__seqid___12724-81__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ISM1 protein levels (SeqId = 8355-80) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ISM1 protein levels (SeqId = 8355-80) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Isthmin-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000058 None Gadd-DA_ism1_protein_levels__seqid___8355-80__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NHEJ1 protein levels (SeqId = 11351-233) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NHEJ1 protein levels (SeqId = 11351-233) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Non-homologous end-joining factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000058 None Gadd-DA_nhej1_protein_levels__seqid___11351-233__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0521305 0.0129621 0.00005805057 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 0.11308 0.028144 0.00005896602 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 DOK2 protein levels (SeqId = 14246-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DOK2 protein levels (SeqId = 14246-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Docking protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.138 0.000059 None Gadd-DA_dok2_protein_levels__seqid___14246-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKT1 protein levels (SeqId = 3392-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKT1 protein levels (SeqId = 3392-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RAC-gamma serine/threonine-protein kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000059 None Gadd-DA_akt1_protein_levels__seqid___3392-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB13 protein levels (SeqId = 19282-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB13 protein levels (SeqId = 19282-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-13 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000059 None Gadd-DA_rab13_protein_levels__seqid___19282-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCER2 protein levels (SeqId = 3291-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCER2 protein levels (SeqId = 3291-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor 774 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.66 0.165 0.000059 None Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARL1 protein levels (SeqId = 12392-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARL1 protein levels (SeqId = 12392-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor-like protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.557 0.139 0.00006 None Gadd-DA_arl1_protein_levels__seqid___12392-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CGB2 protein levels (SeqId = 6213-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CGB2 protein levels (SeqId = 6213-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Choriogonadotropin subunit beta variant 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.556 0.139 0.00006 None Gadd-DA_cgb2_protein_levels__seqid___6213-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.0331199 0.00825204 0.0000601116 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADSSL1 protein levels (SeqId = 13998-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADSSL1 protein levels (SeqId = 13998-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenylosuccinate synthetase isozyme 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.557 0.139 0.000061 None Gadd-DA_adssl1_protein_levels__seqid___13998-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RHOA protein levels (SeqId = 9855-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RHOA protein levels (SeqId = 9855-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transforming protein RhoA 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000061 None Gadd-DA_rhoa_protein_levels__seqid___9855-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB5B protein levels (SeqId = 19222-124) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB5B protein levels (SeqId = 19222-124) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-5B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000062 None Gadd-DA_rab5b_protein_levels__seqid___19222-124__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ANXA7 protein levels (SeqId = 14203-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ANXA7 protein levels (SeqId = 14203-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Annexin A7 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000062 None Gadd-DA_anxa7_protein_levels__seqid___14203-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SYT4 protein levels (SeqId = 17355-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYT4 protein levels (SeqId = 17355-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synaptotagmin-4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.557 0.139 0.000062 None Gadd-DA_syt4_protein_levels__seqid___17355-56__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0377343 0.00941978 0.00006209723 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0378578 0.00945518 0.00006260734 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 UBC protein levels (SeqId = 6647-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBC protein levels (SeqId = 6647-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyubiquitin-C 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000063 None Gadd-DA_ubc_protein_levels__seqid___6647-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RQCD1 protein levels (SeqId = 8975-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RQCD1 protein levels (SeqId = 8975-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CCR4-NOT transcription complex subunit 9 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000063 None Gadd-DA_rqcd1_protein_levels__seqid___8975-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLC26A7 protein levels (SeqId = 13979-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLC26A7 protein levels (SeqId = 13979-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Anion exchange transporter 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.557 0.139 0.000063 None Gadd-DA_slc26a7_protein_levels__seqid___13979-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXLNA protein levels (SeqId = 15698-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXLNA protein levels (SeqId = 15698-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-taxilin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000063 None Gadd-DA_txlna_protein_levels__seqid___15698-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.051704 0.0129268 0.00006371741 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 BAG2 protein levels (SeqId = 19228-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAG2 protein levels (SeqId = 19228-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BAG family molecular chaperone regulator 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.554 0.138 0.000064 None Gadd-DA_bag2_protein_levels__seqid___19228-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADM protein levels (SeqId = 7922-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADM protein levels (SeqId = 7922-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADM 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000064 None Gadd-DA_adm_protein_levels__seqid___7922-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PEBP1 protein levels (SeqId = 4276-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PEBP1 protein levels (SeqId = 4276-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylethanolamine-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000064 None Gadd-DA_pebp1_protein_levels__seqid___4276-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0329868 0.00825208 0.00006435696 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.0329716 0.00825208 0.00006485902 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PPP1CC protein levels (SeqId = 19295-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPP1CC protein levels (SeqId = 19295-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000065 None Gadd-DA_ppp1cc_protein_levels__seqid___19295-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITPA protein levels (SeqId = 18916-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITPA protein levels (SeqId = 18916-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inosine triphosphate pyrophosphatase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000065 None Gadd-DA_itpa_protein_levels__seqid___18916-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFS protein levels (SeqId = 12572-236) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFS protein levels (SeqId = 12572-236) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Embryonal Fyn-associated substrate 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000065 None Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25377313 chr14:88456098 14 88456098 GALC North shelf 0.03302 0.00826811 0.00006538017 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore -0.0329419 0.00825209 0.0000658516 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 RAB2A protein levels (SeqId = 16857-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB2A protein levels (SeqId = 16857-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-2A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000066 None Gadd-DA_rab2a_protein_levels__seqid___16857-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MAPK12 protein levels (SeqId = 5005-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAPK12 protein levels (SeqId = 5005-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitogen-activated protein kinase 12 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.56 0.139 0.000066 None Gadd-DA_mapk12_protein_levels__seqid___5005-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MOB1A protein levels (SeqId = 12426-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MOB1A protein levels (SeqId = 12426-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MOB kinase activator 1A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.554 0.139 0.000066 None Gadd-DA_mob1a_protein_levels__seqid___12426-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BDNF protein levels (SeqId = 2421-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BDNF protein levels (SeqId = 2421-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Brain-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.553 0.139 0.000066 None Gadd-DA_bdnf_protein_levels__seqid___2421-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RIPK2 protein levels (SeqId = 8970-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RIPK2 protein levels (SeqId = 8970-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor-interacting serine/threonine-protein kinase 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000067 None Gadd-DA_ripk2_protein_levels__seqid___8970-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GCA protein levels (SeqId = 12594-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GCA protein levels (SeqId = 12594-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Grancalcin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000067 None Gadd-DA_gca_protein_levels__seqid___12594-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNAI1 protein levels (SeqId = 19271-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNAI1 protein levels (SeqId = 19271-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide-binding protein G(i) subunit alpha-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.554 0.139 0.000068 None Gadd-DA_gnai1_protein_levels__seqid___19271-64__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IFNL1 protein levels (SeqId = 4396-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFNL1 protein levels (SeqId = 4396-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon lambda-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000068 None Gadd-DA_ifnl1_protein_levels__seqid___4396-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ISL1 protein levels (SeqId = 11549-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ISL1 protein levels (SeqId = 11549-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin gene enhancer protein ISL-1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.553 0.139 0.000068 None Gadd-DA_isl1_protein_levels__seqid___11549-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACLY protein levels (SeqId = 12700-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACLY protein levels (SeqId = 12700-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ATP-citrate synthase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000068 None Gadd-DA_acly_protein_levels__seqid___12700-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NCK2 protein levels (SeqId = 13615-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NCK2 protein levels (SeqId = 13615-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytoplasmic protein NCK2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000068 None Gadd-DA_nck2_protein_levels__seqid___13615-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPS4X protein levels (SeqId = 9758-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS4X protein levels (SeqId = 9758-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 40S ribosomal protein S4, X isoform 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000068 None Gadd-DA_rps4x_protein_levels__seqid___9758-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FATE1 protein levels (SeqId = 7740-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FATE1 protein levels (SeqId = 7740-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fetal and adult testis-expressed transcript protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000069 None Gadd-DA_fate1_protein_levels__seqid___7740-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VPS26A protein levels (SeqId = 19293-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VPS26A protein levels (SeqId = 19293-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vacuolar protein sorting-associated protein 26A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000069 None Gadd-DA_vps26a_protein_levels__seqid___19293-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HINT1 protein levels (SeqId = 5900-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HINT1 protein levels (SeqId = 5900-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histidine triad nucleotide-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000069 None Gadd-DA_hint1_protein_levels__seqid___5900-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL4A3BP protein levels (SeqId = 13950-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL4A3BP protein levels (SeqId = 13950-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen type IV alpha-3-binding protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000069 None Gadd-DA_col4a3bp_protein_levels__seqid___13950-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCER2 protein levels (SeqId = 3291-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCER2 protein levels (SeqId = 3291-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor 774 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.71 0.178 0.000069 None Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.0328501 0.00825212 0.00006901025 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TBCB protein levels (SeqId = 17686-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TBCB protein levels (SeqId = 17686-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tubulin-folding cofactor B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.00007 None Gadd-DA_tbcb_protein_levels__seqid___17686-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPS27A protein levels (SeqId = 2846-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS27A protein levels (SeqId = 2846-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-40S ribosomal protein S27a 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.00007 None Gadd-DA_rps27a_protein_levels__seqid___2846-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAD23A protein levels (SeqId = 10058-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAD23A protein levels (SeqId = 10058-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UV excision repair protein RAD23 homolog A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.00007 None Gadd-DA_rad23a_protein_levels__seqid___10058-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.0328138 0.00825213 0.00007030077 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 WSCD2 protein levels (SeqId = 6274-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WSCD2 protein levels (SeqId = 6274-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: WSC domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000071 None Gadd-DA_wscd2_protein_levels__seqid___6274-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF6 protein levels (SeqId = 4130-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF6 protein levels (SeqId = 4130-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000071 None Gadd-DA_fgf6_protein_levels__seqid___4130-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMAD4 protein levels (SeqId = 12022-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMAD4 protein levels (SeqId = 12022-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mothers against decapentaplegic homolog 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000071 None Gadd-DA_smad4_protein_levels__seqid___12022-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARID3A protein levels (SeqId = 3875-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARID3A protein levels (SeqId = 3875-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: AT-rich interactive domain-containing protein 3A 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000072 None Gadd-DA_arid3a_protein_levels__seqid___3875-62__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16679708 chr14:88460078 14 88460078 GALC South shore -0.0394267 0.00993174 0.00007228642 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15731755 chr14:88459269 14 88459269 GALC Island 0.0327559 0.00825214 0.0000724033 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ULBP3 protein levels (SeqId = 2747-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ULBP3 protein levels (SeqId = 2747-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UL16-binding protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000073 None Gadd-DA_ulbp3_protein_levels__seqid___2747-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPM1L protein levels (SeqId = 7187-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPM1L protein levels (SeqId = 7187-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein phosphatase 1L 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000073 None Gadd-DA_ppm1l_protein_levels__seqid___7187-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HOMER1 protein levels (SeqId = 19229-92) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HOMER1 protein levels (SeqId = 19229-92) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homer protein homolog 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.547 0.138 0.000074 None Gadd-DA_homer1_protein_levels__seqid___19229-92__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLXNA4 protein levels (SeqId = 19560-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLXNA4 protein levels (SeqId = 19560-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Plexin-A4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000074 None Gadd-DA_plxna4_protein_levels__seqid___19560-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LAP3 protein levels (SeqId = 13959-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LAP3 protein levels (SeqId = 13959-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytosol aminopeptidase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000074 None Gadd-DA_lap3_protein_levels__seqid___13959-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DOK1 protein levels (SeqId = 16831-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DOK1 protein levels (SeqId = 16831-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Docking protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000074 None Gadd-DA_dok1_protein_levels__seqid___16831-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 VIP protein levels (SeqId = 3522-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VIP protein levels (SeqId = 3522-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: VIP peptides 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000075 None Gadd-DA_vip_protein_levels__seqid___3522-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAB2B protein levels (SeqId = 19253-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAB2B protein levels (SeqId = 19253-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein Rab-2B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.552 0.139 0.000075 None Gadd-DA_rab2b_protein_levels__seqid___19253-82__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD47 protein levels (SeqId = 6653-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD47 protein levels (SeqId = 6653-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte surface antigen CD47 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000075 None Gadd-DA_cd47_protein_levels__seqid___6653-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ULBP1 protein levels (SeqId = 3081-70) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ULBP1 protein levels (SeqId = 3081-70) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UL16-binding protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000076 None Gadd-DA_ulbp1_protein_levels__seqid___3081-70__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MLEC protein levels (SeqId = 6285-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MLEC protein levels (SeqId = 6285-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Malectin 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000076 None Gadd-DA_mlec_protein_levels__seqid___6285-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CROT protein levels (SeqId = 13929-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CROT protein levels (SeqId = 13929-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxisomal carnitine O-octanoyltransferase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.138 0.000076 None Gadd-DA_crot_protein_levels__seqid___13929-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPX7 protein levels (SeqId = 8345-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPX7 protein levels (SeqId = 8345-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione peroxidase 7 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000077 None Gadd-DA_gpx7_protein_levels__seqid___8345-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 JMJD6 protein levels (SeqId = 18322-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 JMJD6 protein levels (SeqId = 18322-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000077 None Gadd-DA_jmjd6_protein_levels__seqid___18322-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NT5C protein levels (SeqId = 12560-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NT5C protein levels (SeqId = 12560-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 5'(3')-deoxyribonucleotidase, cytosolic type 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000078 None Gadd-DA_nt5c_protein_levels__seqid___12560-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDGFRP2 protein levels (SeqId = 4553-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDGFRP2 protein levels (SeqId = 4553-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hepatoma-derived growth factor-related protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000078 None Gadd-DA_hdgfrp2_protein_levels__seqid___4553-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRRF protein levels (SeqId = 12355-223) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRRF protein levels (SeqId = 12355-223) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribosome-recycling factor, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000079 None Gadd-DA_mrrf_protein_levels__seqid___12355-223__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNX5 protein levels (SeqId = 18327-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNX5 protein levels (SeqId = 18327-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sorting nexin-5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.138 0.000079 None Gadd-DA_snx5_protein_levels__seqid___18327-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MRPL52 protein levels (SeqId = 7123-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MRPL52 protein levels (SeqId = 7123-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 39S ribosomal protein L52, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000079 None Gadd-DA_mrpl52_protein_levels__seqid___7123-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RUVBL1 protein levels (SeqId = 12365-108) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RUVBL1 protein levels (SeqId = 12365-108) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RuvB-like 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000079 None Gadd-DA_ruvbl1_protein_levels__seqid___12365-108__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg07416546 chr14:88460351 14 88460351 GALC South shore 1.2 0.315 0.000079 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0512894 0.0129987 0.00007993138 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 MAMDC2 protein levels (SeqId = 6119-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAMDC2 protein levels (SeqId = 6119-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MAM domain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.00008 None Gadd-DA_mamdc2_protein_levels__seqid___6119-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CST2 protein levels (SeqId = 4324-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST2 protein levels (SeqId = 4324-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-SA 774 1 Adults (18-65 years) Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.74 0.188 0.00008 None Gadd-DA_cst2_protein_levels__seqid___4324-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COPS2 protein levels (SeqId = 14029-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COPS2 protein levels (SeqId = 14029-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: COP9 signalosome complex subunit 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000081 None Gadd-DA_cops2_protein_levels__seqid___14029-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.0439482 0.011151 0.00008145211 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07622712 chr14:88461259 14 88461259 GALC South shore -0.0444386 0.0112803 0.00008203837 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04052570 chr14:88459528 14 88459528 GALC Island -0.0332988 0.00845657 0.00008267446 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 L3MBTL2 protein levels (SeqId = 12708-91) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 L3MBTL2 protein levels (SeqId = 12708-91) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lethal(3)malignant brain tumor-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000083 None Gadd-DA_l3mbtl2_protein_levels__seqid___12708-91__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NCR2 protein levels (SeqId = 2734-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NCR2 protein levels (SeqId = 2734-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Natural cytotoxicity triggering receptor 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000083 None Gadd-DA_ncr2_protein_levels__seqid___2734-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore 0.0860442 0.021864 0.00008343206 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 HNRNPD protein levels (SeqId = 18348-89) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HNRNPD protein levels (SeqId = 18348-89) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heterogeneous nuclear ribonucleoprotein D0 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000084 None Gadd-DA_hnrnpd_protein_levels__seqid___18348-89__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MDH1 protein levels (SeqId = 3853-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MDH1 protein levels (SeqId = 3853-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Malate dehydrogenase, cytoplasmic 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000085 None Gadd-DA_mdh1_protein_levels__seqid___3853-56__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SNX8 protein levels (SeqId = 6925-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SNX8 protein levels (SeqId = 6925-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sorting nexin-8 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.138 0.000085 None Gadd-DA_snx8_protein_levels__seqid___6925-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MLF1 protein levels (SeqId = 17820-170) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MLF1 protein levels (SeqId = 17820-170) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myeloid leukemia factor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000086 None Gadd-DA_mlf1_protein_levels__seqid___17820-170__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARAF protein levels (SeqId = 12583-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARAF protein levels (SeqId = 12583-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase A-Raf 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000086 None Gadd-DA_araf_protein_levels__seqid___12583-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DDX6 protein levels (SeqId = 12869-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DDX6 protein levels (SeqId = 12869-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable ATP-dependent RNA helicase DDX6 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000086 None Gadd-DA_ddx6_protein_levels__seqid___12869-68__somascan_protein_measurement Cardenas A Project Viva 31300640 Jul 12, 2019 fractional exhaled nitric oxide (FeNO) EFO_0005536 None Supplementary Data 2 DNA methylation fractional exhaled nitric oxide (FeNO) Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values ppb Illumina HumanMethylationEPIC nasal epithelium None 517 1 Children Both Other cg18322600 chr14:88455060 14 88455060 GALC Open sea -1.98 0.5 0.000086 SE manually calculated 31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_ Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05601096 chr14:88461031 14 88461031 GALC South shore 0.0324147 0.00825223 0.00008605087 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01035038 chr14:88459686 14 88459686 GALC Island 0.129506 0.0329924 0.00008693331 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 METAP1 protein levels (SeqId = 3210-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 METAP1 protein levels (SeqId = 3210-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methionine aminopeptidase 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.138 0.000087 None Gadd-DA_metap1_protein_levels__seqid___3210-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SEZ6L2 protein levels (SeqId = 3867-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SEZ6L2 protein levels (SeqId = 3867-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Seizure 6-like protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000087 None Gadd-DA_sez6l2_protein_levels__seqid___3867-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CNOT1 protein levels (SeqId = 13482-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNOT1 protein levels (SeqId = 13482-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CCR4-NOT transcription complex subunit 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.138 0.000088 None Gadd-DA_cnot1_protein_levels__seqid___13482-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCAR3 protein levels (SeqId = 12634-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCAR3 protein levels (SeqId = 12634-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Breast cancer anti-estrogen resistance protein 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000088 None Gadd-DA_bcar3_protein_levels__seqid___12634-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPS3 protein levels (SeqId = 5026-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS3 protein levels (SeqId = 5026-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 40S ribosomal protein S3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.000089 None Gadd-DA_rps3_protein_levels__seqid___5026-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0369782 0.00943632 0.00008942821 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ADK protein levels (SeqId = 19207-119) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADK protein levels (SeqId = 19207-119) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenosine kinase 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.00009 None Gadd-DA_adk_protein_levels__seqid___19207-119__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 STAU2 protein levels (SeqId = 12970-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAU2 protein levels (SeqId = 12970-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Double-stranded RNA-binding protein Staufen homolog 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.55 0.139 0.00009 None Gadd-DA_stau2_protein_levels__seqid___12970-35__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0369585 0.00943604 0.00009015975 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ARF4 protein levels (SeqId = 18408-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARF4 protein levels (SeqId = 18408-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000091 None Gadd-DA_arf4_protein_levels__seqid___18408-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CABLES2 protein levels (SeqId = 7105-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CABLES2 protein levels (SeqId = 7105-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CDK5 and ABL1 enzyme substrate 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.14 0.000091 None Gadd-DA_cables2_protein_levels__seqid___7105-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21274300 chr14:88459745 14 88459745 GALC South shore 0.0322986 0.00825226 0.00009122574 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 UBE2L3 protein levels (SeqId = 3874-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2L3 protein levels (SeqId = 3874-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 L3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000092 None Gadd-DA_ube2l3_protein_levels__seqid___3874-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CDKN1A protein levels (SeqId = 18291-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDKN1A protein levels (SeqId = 18291-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinase inhibitor 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000092 None Gadd-DA_cdkn1a_protein_levels__seqid___18291-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore -0.077449 0.0198108 0.00009293292 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 UBE2D2 protein levels (SeqId = 18842-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2D2 protein levels (SeqId = 18842-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 D2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000093 None Gadd-DA_ube2d2_protein_levels__seqid___18842-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04738877 chr14:88459963 14 88459963 GALC South shore 0.0322474 0.00825228 0.0000936005 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ST13 protein levels (SeqId = 18387-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST13 protein levels (SeqId = 18387-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hsc70-interacting protein 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000094 None Gadd-DA_st13_protein_levels__seqid___18387-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CUL4B protein levels (SeqId = 13743-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CUL4B protein levels (SeqId = 13743-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cullin-4B 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000094 None Gadd-DA_cul4b_protein_levels__seqid___13743-56__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAG1 protein levels (SeqId = 11311-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAG1 protein levels (SeqId = 11311-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: V(D)J recombination-activating protein 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000094 None Gadd-DA_rag1_protein_levels__seqid___11311-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CTRC protein levels (SeqId = 5626-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTRC protein levels (SeqId = 5626-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chymotrypsin-C 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000094 None Gadd-DA_ctrc_protein_levels__seqid___5626-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CS protein levels (SeqId = 18309-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CS protein levels (SeqId = 18309-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Citrate synthase, mitochondrial 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000094 None Gadd-DA_cs_protein_levels__seqid___18309-18__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18322600 chr14:88455060 14 88455060 GALC Open sea -0.159549 0.0408457 0.00009412566 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19827 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P19827 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17192520 chr14:88461468 14 88461468 GALC South shore -0.0862525 0.0220808 0.0000941686 P19827 41361833_Josephine_Robertson_P19827_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 BAG1 protein levels (SeqId = 17195-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BAG1 protein levels (SeqId = 17195-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: BAG family molecular chaperone regulator 1 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000095 None Gadd-DA_bag1_protein_levels__seqid___17195-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GCLM protein levels (SeqId = 18214-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GCLM protein levels (SeqId = 18214-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutamate--cysteine ligase regulatory subunit 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000095 None Gadd-DA_gclm_protein_levels__seqid___18214-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EHD4 protein levels (SeqId = 11421-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EHD4 protein levels (SeqId = 11421-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: EH domain-containing protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000095 None Gadd-DA_ehd4_protein_levels__seqid___11421-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRDM4 protein levels (SeqId = 12779-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRDM4 protein levels (SeqId = 12779-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PR domain zinc finger protein 4 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000096 None Gadd-DA_prdm4_protein_levels__seqid___12779-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADH5 protein levels (SeqId = 11369-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH5 protein levels (SeqId = 11369-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase class-3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000096 None Gadd-DA_adh5_protein_levels__seqid___11369-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PFDN5 protein levels (SeqId = 4271-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PFDN5 protein levels (SeqId = 4271-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prefoldin subunit 5 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000096 None Gadd-DA_pfdn5_protein_levels__seqid___4271-75__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACYP2 protein levels (SeqId = 12812-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACYP2 protein levels (SeqId = 12812-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acylphosphatase-2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000097 None Gadd-DA_acyp2_protein_levels__seqid___12812-25__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03495202 chr14:88457365 14 88457365 GALC North shore 0.0321667 0.0082523 0.00009746131 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GDNF protein levels (SeqId = 5822-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDNF protein levels (SeqId = 5822-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glial cell line-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.138 0.000098 None Gadd-DA_gdnf_protein_levels__seqid___5822-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BRD2 protein levels (SeqId = 15372-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BRD2 protein levels (SeqId = 15372-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bromodomain-containing protein 2 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000098 None Gadd-DA_brd2_protein_levels__seqid___15372-43__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTP4A3 protein levels (SeqId = 19231-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTP4A3 protein levels (SeqId = 19231-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein tyrosine phosphatase type IVA 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000098 None Gadd-DA_ptp4a3_protein_levels__seqid___19231-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CEACAM3 protein levels (SeqId = 8999-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CEACAM3 protein levels (SeqId = 8999-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carcinoembryonic antigen-related cell adhesion molecule 3 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000099 None Gadd-DA_ceacam3_protein_levels__seqid___8999-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SUGT1 protein levels (SeqId = 17818-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUGT1 protein levels (SeqId = 17818-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein SGT1 homolog 774 1 Adults (18-65 years) Both European cg10122474 chr14:88459471 14 88459471 GALC Island -0.54 0.139 0.000099 None Gadd-DA_sugt1_protein_levels__seqid___17818-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TCL1A protein levels (SeqId = 17210-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TCL1A protein levels (SeqId = 17210-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-cell leukemia/lymphoma protein 1A 774 1 Adults (18-65 years) Both European cg10055685 chr14:88461489 14 88461489 GALC South shore 0.64 0.165 0.000099 None Gadd-DA_tcl1a_protein_levels__seqid___17210-2__somascan_protein_measurement