author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.0057 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf -0.0037 0.00029 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf -0.028 0.0033 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf -0.0016 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf -0.0013 0.00011 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf -0.038 0.0036 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf -0.018 0.0018 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24819266 chr10:35893624 10 35893624 GJD4 North shelf -0.0021 0.00016 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24819266 chr10:35893624 10 35893624 GJD4 North shelf 0.39859 0.00687 3.8e-124 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf 0.18249 0.00536 1.7e-83 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10258719 chr10:35896405 10 35896405 GJD4 North shore 0.09696 0.00363 9.2e-67 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.09815 0.00369 2.2e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf 0.10957 0.00512 7.099999999999999e-53 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf - - 9.01e-51 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16742003 chr10:35894207 10 35894207 GJD4 North shelf 0.08352 0.00448 4.3e-45 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25281042 chr10:35897304 10 35897304 GJD4 Island 0.0832 0.00491 4.8e-40 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg08541962 chr10:35894321 10 35894321 GJD4 North shelf -1.79312 0.07833 1.3799999999999999e-38 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg20732198 chr10:35894310 10 35894310 GJD4 North shelf -1.4691 0.07532 1.6200000000000002e-33 - 25282492_fetal_vs_adult_liver Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg12630277 chr10:35894012 10 35894012 GJD4 North shelf -0.0585 0.00401 5.7e-33 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg10258719 chr10:35896405 10 35896405 GJD4 North shore 1.40976 0.08932 2.9e-27 - 25282492_fetal_vs_adult_liver Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.0166 0.0019122 1.96e-18 - 28811542_age Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf -0.02944 0.00306 3.5e-18 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.02 0.0025 0.0000000000000076 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf 0.012 0.0015 0.000000000000012 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg12630277 chr10:35894012 10 35894012 GJD4 North shelf - - 0.0000000000000141 - 28056824_age_4_vs_age_0 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16742003 chr10:35894207 10 35894207 GJD4 North shelf 0.0018 None 0.00000000000032 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12630277 chr10:35894012 10 35894012 GJD4 North shelf -0.0016 0.00022 0.00000000000034 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf 0.0012 None 0.0000000000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18826070 chr10:35897822 10 35897822 GJD4 South shore -0.0011 0.00016 0.0000000000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10258719 chr10:35896405 10 35896405 GJD4 North shore -0.012 0.0019 0.00000000013 None 33450751_Mulder-RH_sex_discovery Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf - - 0.000000000172 - 28056824_age_4_vs_age_0 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16742003 chr10:35894207 10 35894207 GJD4 North shelf 0.0012 0.00019 0.00000000038 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.001 0.00016 0.00000000045 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg18826070 chr10:35897822 10 35897822 GJD4 South shore -1.693746 0.2732 0.000000000568 - 27105112_hiv_infection_discovery Yang BZ - 23332324 2013-02-01 Child abuse - - Appendix B DNA methylation Child abuse Sex, age and ethnicity Beta values - Illumina HumanMethylation450 Saliva - 192 1 10 Both European,African,Admixed,Other cg18826070 chr10:35897822 10 35897822 GJD4 South shore - - 0.000000001 - 23332324_child_abuse Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf -0.0372 0.00583 0.0000000026 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf -0.0268 0.00425 0.0000000035 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02483554 chr10:35894194 10 35894194 GJD4 North shelf -0.0088 0.0015 0.00000001 None 33450751_Mulder-RH_sex_discovery Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf -0.0397 0.00656 0.000000012 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf - - 0.0000000284 - 26857698_primary_sjogrens_syndrome_whole_blood Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf -0.0272 0.00463 0.000000031 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24819266 chr10:35893624 10 35893624 GJD4 North shelf 0.0013 None 0.000000052 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf -0.004 0.00073 0.000000053 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16981024 chr10:35896654 10 35896654 GJD4 Island 0.03267 0.00594 0.00000012 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf 0.0331 0.00609 0.00000015 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16742003 chr10:35894207 10 35894207 GJD4 North shelf -0.011 0.0021 0.00000017 None 33450751_Mulder-RH_sex_discovery Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg16981024 chr10:35896654 10 35896654 GJD4 Island None None 0.00000021 None 34584077_Jenny-van-Dongen_monozygotic_twinning Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf 0.0331 0.00619 0.00000022 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf -0.00085 0.00016 0.00000028 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf 0.0215 0.00406 0.00000029 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg12630277 chr10:35894012 10 35894012 GJD4 North shelf 6 None 0.00000045 None 34044884_Inkster-A_sex_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf - - 0.000000498 - 26500701_sex_kora_f4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14187335 chr10:35896950 10 35896950 GJD4 Island 0.02791 0.00542 0.00000063 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg14187335 chr10:35896950 10 35896950 GJD4 Island None None 0.0000013 None 34584077_Jenny-van-Dongen_monozygotic_twinning Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg08541962 chr10:35894321 10 35894321 GJD4 North shelf - - 0.00000208 - 26500701_sex_kora_f4 Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf 0.0209 0.00457 0.0000082 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf -0.156951 0.0354241 0.000009453488 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09931939 chr10:35894295 10 35894295 GJD4 North shelf 0.0036 None 0.000016 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf 0.0178 0.00404 0.000016 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf - - 0.0000305 - 26500701_sex_kora_f4 Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf 0.0091 0.0021 0.000031 None 34427971_Tan-Q_age_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf 0.0022 None 0.000039 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 CSF2RB protein levels (SeqId = 11137-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSF2RB protein levels (SeqId = 11137-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytokine receptor common subunit beta 774 1 Adults (18-65 years) Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf -0.64 0.155 0.000041 None Gadd-DA_csf2rb_protein_levels__seqid___11137-43__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25281042 chr10:35897304 10 35897304 GJD4 Island 0.00059 0.00014 0.000041 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 OLFM3 protein levels (SeqId = 10643-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OLFM3 protein levels (SeqId = 10643-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Noelin-3 774 1 Adults (18-65 years) Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf -0.64 0.155 0.000042 None Gadd-DA_olfm3_protein_levels__seqid___10643-16__somascan_protein_measurement Odintsova VV Netherlands Twin Register 31744183 2019-11-17 Breastfeeding duration EFO_0006864 Discovery, adjusted model, only children younger than 10 Table S15 DNA methylation Breastfeeding duration Sex, age, cell composition (reference based), batch effects, socioeconomic position, maternal smoking, maternal age, maternal body mass index at pregnancy, gestational age Beta Values None Illumina HumanMethylationEPIC Buccal cells duration split into 6 categories 517 1 Children Both European cg16981024 chr10:35896654 10 35896654 GJD4 Island 0.00423 0.001 0.000043 None 31744183_Odintsova-VV_breastfeeding_duration_discovery__adjusted_model__only_children_younger_than_10 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf 0.0058 0.0014 0.000046 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf -0.147392 0.036234 0.00004767377 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10258719 chr10:35896405 10 35896405 GJD4 North shore 0.0048 0.0012 0.000048 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18026141 chr10:35893451 10 35893451 GJD4 North shelf -0.03349 0.00825194 0.00004965834 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg23900225 chr10:35894222 10 35894222 GJD4 North shelf - - 0.000052 - 26500701_sex_kora_f4 Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS11B protein levels (SeqId = 10895-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS11B protein levels (SeqId = 10895-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 11B 774 1 Adults (18-65 years) Both European cg10133248 chr10:35893437 10 35893437 GJD4 North shelf -0.62 0.155 0.00006 None Gadd-DA_tmprss11b_protein_levels__seqid___10895-28__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12630277 chr10:35894012 10 35894012 GJD4 North shelf 0.006 0.0015 0.000064 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16742003 chr10:35894207 10 35894207 GJD4 North shelf 0.0048 0.0012 0.000068 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg00168942 chr10:35894430 10 35894430 GJD4 North shelf - - 0.0000753 - 26500701_sex_kora_f4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20732198 chr10:35894310 10 35894310 GJD4 North shelf -0.0012 0.00032 0.000076 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14187335 chr10:35896950 10 35896950 GJD4 Island 0.0322226 0.00825228 0.00009476887 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24819266 chr10:35893624 10 35893624 GJD4 North shelf 0.0034 None 0.000095 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect