author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00136105 chr12:102224911 12 102224911 GNPTAB South shore -0.00018 0.00002 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0051 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0031 0.00026 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08157318 chr12:102224140 12 102224140 GNPTAB North shore -0.0023 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12395649 chr12:102144460 12 102144460 GNPTAB Open sea -0.0028 0.00033 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0019 0.00014 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore -0.0014 0.00016 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf 0.54558 0.00781 5.3e-139 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore 0.52384 0.00772 1.3e-136 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.49258 0.00781 9.999999999999999e-131 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24032890 chr12:102139493 12 102139493 GNPTAB Open sea 0.52925 0.00942 1.4e-121 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.152991 0.00815937 1.549031e-77 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.1424 0.00508 5.8e-70 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.122553 0.00819433 3.3438999999999997e-50 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg12395649 chr12:102144460 12 102144460 GNPTAB Open sea 0.06228 0.00332 1.9e-45 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.108665 0.00820768 8.783192e-40 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.100699 0.0082146 2.226132e-34 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0975418 0.0082172 2.370565e-32 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0889114 0.00822387 3.848339e-27 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0868366 0.00822538 5.833324e-26 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3428671 (gene symbol: SYCP3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3428671 (gene symbol: SYCP3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 2.2999999999999997e-24 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3428671__gene_symbol__sycp3__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0833451 0.00822784 4.896499e-24 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore - - 4.41e-21 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea 0.02575 0.00245 9e-21 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0751535 0.00823322 7.866532e-20 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0744291 0.00823367 1.7661849999999998e-19 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0727311 0.0082347 1.140411e-18 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0723423 0.00823494 1.737746e-18 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0707717 0.00823587 9.309552e-18 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.06983 0.00823642 2.5029250000000003e-17 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0687143 0.00823706 7.943138e-17 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0661809 0.00823847 0.000000000000001021915 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13138088 chr12:102224849 12 102224849 GNPTAB South shore -0.000085 0.000011 0.0000000000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg00136105 chr12:102224911 12 102224911 GNPTAB South shore 0.01369 0.0018 0.0000000000000336 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0617777 0.0082408 0.00000000000006925664 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea - - 0.000000000000163 - 26500701_sex_kora_f4 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.07295 0.0099 0.000000000000194 - 25650246_gestational_age Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg13138088 chr12:102224849 12 102224849 GNPTAB South shore 0.00845 0.0012 0.000000000000355 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0598161 0.00824179 0.0000000000004135842 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08157318 chr12:102224140 12 102224140 GNPTAB North shore -0.02801 0.00362 0.00000000000053 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0594379 0.00824197 0.0000000000005800044 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06554542 chr12:102224375 12 102224375 GNPTAB Island 0.0003 0.000042 0.00000000000097 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg23541617 chr12:102225335 12 102225335 GNPTAB South shore 0.0064 0.0008 0.000000000001 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0587839 0.00824229 0.000000000001035562 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg10697784 chr12:102222181 12 102222181 GNPTAB North shelf -0.02375 0.0033 0.00000000000104 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0578233 0.00824276 0.000000000002399486 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.031 0.00439 0.0000000000032 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0574219 0.00824295 0.00000000000339502 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0573132 0.008243 0.000000000003728097 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.059694 0.00860914 0.000000000004268321 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0549985 0.00824407 0.0000000000262679 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0549792 0.00824408 0.00000000002668978 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.054978 0.00824408 0.00000000002671561 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0572973 0.0086041 0.00000000002849055 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0545827 0.00824426 0.00000000003699656 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea -0.286197 0.0432494 0.00000000003758712 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0055 0.00077 0.000000000098 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0530666 0.00824494 0.0000000001262566 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0529793 0.00824498 0.0000000001353572 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0550987 0.00860641 0.0000000001579683 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore -0.0517698 0.0082455 0.0000000003513655 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0517383 0.00824551 0.0000000003600872 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.051683 0.00824554 0.0000000003759414 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0513332 0.00824569 0.0000000004932083 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0513057 0.0082457 0.0000000005038235 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea 0.0011 None 0.00000000059 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.051094 0.00824579 0.00000000059322 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0510101 0.00824582 0.0000000006327752 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00025343 4.1e-05 0.000000000639 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0530466 0.00862341 0.0000000007876374 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.050602 0.00824599 0.0000000008649707 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0505944 0.008246 0.0000000008700436 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0525672 0.00859148 0.0000000009684697 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0503619 0.00824609 0.000000001038502 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0671569 0.0110609 0.000000001298233 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0500476 0.00824622 0.000000001317536 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0497666 0.00824634 0.000000001628001 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0514837 0.00864099 0.000000002610589 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0488586 0.00824671 0.00000000320031 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0505433 0.00862611 0.000000004746684 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00096 0.00016 0.0000000053 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17472390 chr12:102224465 12 102224465 GNPTAB Island 0.00038 0.000066 0.0000000068 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg12395649 chr12:102144460 12 102144460 GNPTAB Open sea -0.02995 0.0053 0.0000000119 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0468278 0.00824751 0.00000001390122 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.046776 0.00824753 0.00000001442134 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.000000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0463709 0.00824769 0.00000001918774 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0461579 0.00824777 0.00000002227603 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0479996 0.0085861 0.0000000230612 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.0455387 0.00824801 0.00000003424604 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0017 None 0.000000035 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0472199 0.00857054 0.0000000365787 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0452929 0.0082481 0.00000004055898 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08157318 chr12:102224140 12 102224140 GNPTAB North shore -0.00898 0.00164 0.000000042 None 33279932_Li-M_schizophrenia_main Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.023 0.00389 0.000000049 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea -0.0447135 0.00824831 0.000000060229 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea -0.0467894 0.00863319 0.00000006064011 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.00000007 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0521475 0.00969883 0.00000007703527 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10697784 chr12:102222181 12 102222181 GNPTAB North shelf 0.01478 0.00266 0.000000087 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0439951 0.00824858 0.00000009767851 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0439762 0.00824858 0.00000009892481 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0464956 0.00877024 0.000000116507 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0437274 0.00824867 0.000000116749 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0434545 0.00824877 0.000000139867 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0434268 0.00824878 0.0000001424533 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea 0.23362 0.0444681 0.0000001508775 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0433263 0.00824882 0.000000152203 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0432475 0.00824885 0.0000001603022 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.006 0.0011 0.00000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.043123 0.00824889 0.00000017396 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0453092 0.00878525 0.000000253639 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0424381 0.00824913 0.0000002716195 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.00000028 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.045157 0.00879213 0.0000002841403 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.00000038 None 31789449_Dugue-P-A_alcohol_consumption_replication Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08157318 chr12:102224140 12 102224140 GNPTAB North shore None None 0.00000038 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0988531 0.0194718 0.0000003887138 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0417657 0.00824937 0.0000004179374 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.023 0.00464 0.00000042 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0433376 0.00860157 0.0000004751665 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.04429 0.00880104 0.0000004902004 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0440987 0.00878289 0.0000005201429 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0413222 0.00824952 0.0000005533596 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.041305 0.00824953 0.0000005593913 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0412794 0.00824953 0.0000005684847 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12395649 chr12:102144460 12 102144460 GNPTAB Open sea 0.0022 None 0.00000063 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0410481 0.00824961 0.0000006572916 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.0408714 0.00824967 0.0000007339544 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0424535 0.00857594 0.0000007492228 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0408166 0.00824969 0.0000007594505 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0407564 0.00824971 0.0000007884509 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea - - 0.000000796 - 26500701_sex_metaanalysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0059 0.0012 0.00000088 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf 0.0427662 0.00879507 0.000001171034 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0400019 0.00824996 0.000001255251 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0394744 0.00825014 0.000001729135 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0394612 0.00825014 0.000001742911 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.008 0.0017 0.0000018 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea 0.212489 0.0445762 0.000001886368 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0408544 0.00859967 0.000002046391 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Parkinson's Disease None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Parkinson's Disease Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14364 1 Adults (18-65y) Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore -0.0071 0.0015 0.0000024 None Robert-F-Hillary_Incident_Parkinson's_Disease_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0401857 0.0085892 0.00000291383 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore -0.0385582 0.00825043 0.00000298774 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0639995 0.0137014 0.000003023857 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.0000031 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0409459 0.00878411 0.00000316897 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0400412 0.00861459 0.00000337973 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.00054299 0.00011676 0.00000373 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03812242 chr12:102186032 12 102186032 GNPTAB Open sea 0.0381333 0.00825057 0.000003834815 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0380907 0.00825058 0.00000393138 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.038047 0.00825059 0.000004032916 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0405165 0.00879786 0.000004154075 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg23541617 chr12:102225335 12 102225335 GNPTAB South shore None None 0.0000045 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0378073 0.00825067 0.000004636024 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08157318 chr12:102224140 12 102224140 GNPTAB North shore -0.0377545 0.00825068 0.000004780189 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0377059 0.0082507 0.000004916575 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0626857 0.0137261 0.000004990167 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.75 0.165 0.000005 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea 0.036 0.00779 0.0000051 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea -0.0375793 0.00825074 0.000005289212 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea 0.0374005 0.00825079 0.000005862261 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.00056189 0.00012346 0.00000595 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0373283 0.00825082 0.000006110086 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf 0.0399803 0.00884661 0.000006253533 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.037225 0.00825085 0.000006482396 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10697784 chr12:102222181 12 102222181 GNPTAB North shelf 0.0058 0.0013 0.0000065 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0376629 0.00838163 0.0000070597 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Dunn E ARIES 30905381 2019-01-21 Neighhorhood Disadvantage None Adversity was experienced between ages 1.5 years and 7 years old Table S3 DNA methylation Neighhorhood Disadvantage Ancestry (other), birth weight, maternal age, socioeconomic position, number of previous maternal pregnancies Beta Values None Illumina HumanMethylation450 Leukocytes None 774 1 Children Both Unclear cg13138088 chr12:102224849 12 102224849 GNPTAB South shore None None 0.0000073 very early childhood (age 1.75) 30905381_Dunn-E_neighhorhood_disadvantage_adversity_was_experienced_between_ages_1_5_years_and_7_years_old Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24032890 chr12:102139493 12 102139493 GNPTAB Open sea -0.0014 0.00031 0.0000073 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24032890 chr12:102139493 12 102139493 GNPTAB Open sea 0.014 0.003 0.0000075 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03812242 chr12:102186032 12 102186032 GNPTAB Open sea 0.0372119 0.00830698 0.000007535273 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0505318 0.0113251 0.000008183626 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03812242 chr12:102186032 12 102186032 GNPTAB Open sea 0.190739 0.0427608 0.000008224122 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25056195 chr12:102224470 12 102224470 GNPTAB Island 0.13987 0.0314052 0.000008489312 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 SMPD1 protein levels (SeqId = 10818-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMPD1 protein levels (SeqId = 10818-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sphingomyelin phosphodiesterase 774 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.6 0.135 0.0000091 None Gadd-DA_smpd1_protein_levels__seqid___10818-36__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0365018 0.00825107 0.00000976395 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.036475 0.00825108 0.000009911647 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0363496 0.00825112 0.00001063308 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.26354 0.0599135 0.00001095671 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 EDAR protein levels (SeqId = 2977-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EDAR protein levels (SeqId = 2977-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor receptor superfamily member EDAR 774 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.62 0.141 0.000011 None Gadd-DA_edar_protein_levels__seqid___2977-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0611341 0.0139054 0.00001108285 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0361579 0.00825117 0.00001183302 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea 1.9 0.432 0.000013 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02423661 chr12:102191730 12 102191730 GNPTAB Open sea -0.225838 0.0519567 0.00001389832 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.000014 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea 0.033 0.00767 0.000015 None Robert-F-Hillary_Incident_COPD_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0048 0.0011 0.000015 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf -0.0356948 0.00825131 0.00001528733 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0486024 0.0112532 0.00001577802 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18741549 chr12:102160736 12 102160736 GNPTAB Open sea -0.176456 0.0408895 0.00001601663 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27136130 chr12:102173158 12 102173158 GNPTAB Open sea -0.0357403 0.00830147 0.00001678444 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0352852 0.00820835 0.00001729171 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0353633 0.00825141 0.00001832991 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0352713 0.00825143 0.00001927245 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore -0.0352702 0.00825143 0.00001928302 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0352679 0.00825144 0.00001930782 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0352611 0.00825144 0.00001937944 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02423661 chr12:102191730 12 102191730 GNPTAB Open sea 0.0349483 0.00819263 0.00002004137 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23541617 chr12:102225335 12 102225335 GNPTAB South shore 0.0350666 0.00825149 0.0000215358 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24032890 chr12:102139493 12 102139493 GNPTAB Open sea -0.0087 0.002 0.000022 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0350086 0.00825151 0.0000222211 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.036977 0.00871864 0.00002237428 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 IL10RA protein levels (SeqId = 8104-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL10RA protein levels (SeqId = 8104-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-10 receptor subunit alpha 774 1 Adults (18-65 years) Both European cg06449573 chr12:102153611 12 102153611 GNPTAB Open sea 0.61 0.144 0.000024 None Gadd-DA_il10ra_protein_levels__seqid___8104-21__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.034771 0.00825158 0.00002525457 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0587975 0.0139649 0.00002564603 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0346975 0.0082516 0.00002627006 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Pain (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Pain (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 18413 1 Adults (18-65y) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea 0.19 0.046 0.000027 None Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea -0.0363165 0.00865124 0.0000271061 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea 0.0345917 0.00825163 0.00002780038 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27136130 chr12:102173158 12 102173158 GNPTAB Open sea -0.0346132 0.00828497 0.00002960038 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Wilson LE The Normal Breast Study 30938765 2019-02-14 Alcohol Consumption EFO_0004329, EFO_0007878 replication in breast tissue Table 5 DNA methylation Alcohol Consumption Age, breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based) M Values drinks per week Illumina HumanMethylation450 Whole blood, breast tissue Discovery P-value not reported 171 1 Adults Females Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.00003 None 30938765_Wilson-LE_alcohol_consumption_replication_in_breast_tissue Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0344442 0.00825167 0.00003007568 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0360736 0.00864302 0.00003013873 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0344245 0.00825168 0.00003039103 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SERPINA3 protein levels (SeqId = 4153-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPINA3 protein levels (SeqId = 4153-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1-antichymotrypsin 774 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.76 0.184 0.000031 None Gadd-DA_serpina3_protein_levels__seqid___4153-11__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg00651106 chr12:102191003 12 102191003 GNPTAB Open sea 0.038 0.00918 0.000032 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0470244 0.0113072 0.00003217547 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Wilson LE Sister Study 30938765 2019-02-14 Alcohol Consumption EFO_0004329, EFO_0007878 replication Web Table 1 DNA methylation Alcohol Consumption Age, breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based) M Values drinks per week Illumina HumanMethylation450 Whole blood Discovery P-value not reported 187 1 Adults Females Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.000033 None 30938765_Wilson-LE_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03812242 chr12:102186032 12 102186032 GNPTAB Open sea 0.0342403 0.00827332 0.00003513177 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0362693 0.00877715 0.00003612378 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20203297 chr12:102221075 12 102221075 GNPTAB North shelf 0.0340579 0.00825178 0.00003690131 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea 0.0379116 0.00918569 0.00003691637 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0362463 0.00878388 0.00003704376 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.0340241 0.00825179 0.00003756485 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0355133 0.00861644 0.00003783706 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.033977 0.0082518 0.00003850686 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea 0.0339585 0.00825181 0.0000388817 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0339252 0.00825182 0.00003956898 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0339023 0.00825183 0.00004004722 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0398264 0.00972482 0.00004238279 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0450441 0.0110152 0.00004350481 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12395649 chr12:102144460 12 102144460 GNPTAB Open sea 0.013 0.0032 0.000044 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02423661 chr12:102191730 12 102191730 GNPTAB Open sea 0.0335983 0.00825191 0.00004694133 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0383192 0.00945218 0.00005060775 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg03812242 chr12:102186032 12 102186032 GNPTAB Open sea -0.168795 0.0416711 0.00005128542 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0333977 0.00825197 0.0000520914 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0333091 0.00825199 0.0000545316 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea 0.0332719 0.008252 0.00005558887 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18059 1 Adults (18-65y) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea 0.078 0.0195 0.000056 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0339009 0.00843392 0.0000585906 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00518 0.00129 0.000059 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea 0.0330592 0.00825206 0.00006201529 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg23541617 chr12:102225335 12 102225335 GNPTAB South shore 0.006 0.002 0.0000633 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0330191 0.00825207 0.00006330262 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Battram T GEO 23334450 2020-09-15 Rheumatoid arthritis EFO_0000685 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861 None DNA methylation Rheumatoid arthritis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 689 1 Adults Both European cg10697784 chr12:102222181 12 102222181 GNPTAB North shelf -0.0113 0.00283 0.000066 None 23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea 0.0329142 0.0082521 0.00006679112 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea None None 0.000068 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea -0.0328612 0.00825211 0.00006862353 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0328236 0.00825212 0.00006994996 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea 0.081 0.0203 0.00007 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea 0.0327999 0.00825213 0.00007079871 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GRAP2 protein levels (SeqId = 16074-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRAP2 protein levels (SeqId = 16074-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GRB2-related adapter protein 2 774 1 Adults (18-65 years) Both European cg00136105 chr12:102224911 12 102224911 GNPTAB South shore 0.47 0.118 0.000077 None Gadd-DA_grap2_protein_levels__seqid___16074-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0326267 0.00825218 0.00007730852 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.032598 0.00825218 0.00007844096 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea 0.0325339 0.0082522 0.00008102916 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14600011 chr12:102213475 12 102213475 GNPTAB Open sea 0.0324537 0.00825222 0.00008437384 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02244234 chr12:102183148 12 102183148 GNPTAB Open sea 0.0324035 0.00825224 0.0000865353 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0323316 0.00825225 0.00008972597 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.0344462 0.00879211 0.00008974865 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12340037 chr12:102193720 12 102193720 GNPTAB Open sea -0.0546654 0.0139639 0.00009090199 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea -0.0322892 0.00825227 0.00009165429 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03756485 chr12:102218837 12 102218837 GNPTAB Open sea 0.034103 0.00871869 0.0000921449 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0322736 0.00825227 0.00009237552 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0335936 0.00860374 0.000094828 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02221130 chr12:102167960 12 102167960 GNPTAB Open sea -0.0322182 0.00825229 0.00009497754 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08067349 chr12:102187313 12 102187313 GNPTAB Open sea -0.0335303 0.00860597 0.00009816082 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17214456 chr12:102216984 12 102216984 GNPTAB Open sea -0.0321244 0.00825231 0.00009954149 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1