author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00581848	chr1:9189367	1	9189367	GPR157	Island	-0.0012	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03520085	chr1:9189344	1	9189344	GPR157	Island	-0.0012	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06374766	chr1:9188925	1	9188925	GPR157	Island	-0.0001	0.000011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0016	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.00007	0.0000077	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12271223	chr1:9189272	1	9189272	GPR157	Island	-0.00032	0.000023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18040436	chr1:9189312	1	9189312	GPR157	Island	-0.0018	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18131499	chr1:9189322	1	9189322	GPR157	Island	-0.0012	0.00007	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-0.0094	0.00063	0	None	33450751_Mulder-RH_sex_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.41882	0.00621	3.9e-136	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	0.49316	0.00754	1.2e-133	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	0.13306	0.0023	5.4e-124	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03583311	chr1:9187976	1	9187976	GPR157	North shore	0.39481	0.00828	1e-108	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.24259	0.00759	4.6e-79	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Replication	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	445	1	79	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-	-	9.999999999999999e-51	-	25249537_sex_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.115424	0.00820139	1.0757809999999999e-44	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.111675	0.00820492	6.209714e-42	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.110443	0.00820606	4.798001e-41	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.106511	0.0082096	2.791295e-38	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.09557	0.00586	3.7e-38	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.10065	0.00821464	2.397562e-34	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0946028	0.00821954	1.597736e-30	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0899997	0.00822306	9.012239e-28	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0898604	0.00822317	1.0863020000000001e-27	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	0.00081	None	2.1999999999999997e-25	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0788391	0.00823087	1.13986e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0787435	0.00823093	1.275382e-21	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-1.9	0.2	1.6e-21	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0730396	0.00823452	8.151956999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0729407	0.00823458	9.079462e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0724681	0.00823486	1.516749e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.046	0.00525	4.6e-18	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0706857	0.00823592	1.0195060000000002e-17	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0690589	0.00823686	5.570785e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0687495	0.00823704	7.660869e-17	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0682673	0.00823731	1.25518e-16	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-	-	1.33e-16	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.065971	0.00823858	0.000000000000001257355	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.238237	0.0304188	0.000000000000005083409	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0631654	0.00824008	0.0000000000000189101	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0625862	0.00824039	0.00000000000003262007	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0624937	0.00824043	0.00000000000003556963	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.02457	0.00303	0.000000000000055	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0618782	0.00824075	0.00000000000006310272	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0611176	0.00824114	0.000000000000127161	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg00581848	chr1:9189367	1	9189367	GPR157	Island	-0.011	0.00132	0.00000000000022	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0612249	0.00834534	0.000000000000230888	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0604543	0.00824147	0.0000000000002326801	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.06034	0.00824153	0.0000000000002580426	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0601653	0.00824161	0.0000000000003021393	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.00093207	0.00012626	0.000000000000314	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.060236	0.00827203	0.0000000000003459219	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	0.00051	None	0.00000000000038	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0595674	0.00824191	0.0000000000005166871	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.0586891	0.00824234	0.000000000001125793	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0586834	0.00824234	0.000000000001131476	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.344068	0.0483802	0.000000000001190517	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0583274	0.00824251	0.000000000001546493	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0578415	0.00824275	0.00000000000236188	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0575741	0.00824288	0.000000000002977325	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0575395	0.00824289	0.000000000003067592	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0578732	0.0083494	0.000000000004340077	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20323445	chr1:9189669	1	9189669	GPR157	Island	0.00034	None	0.0000000000057	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0801043	0.0116226	0.000000000005721844	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0567149	0.00824328	0.000000000006221657	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0061	0.00089	0.0000000000082	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0561334	0.00831393	0.0000000000151582	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27178407	chr1:9189213	1	9189213	GPR157	Island	-0.00057	0.000084	0.000000000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.203829	0.0304571	0.00000000002263564	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0548445	0.00824414	0.00000000002982891	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-	-	0.0000000000311	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0546679	0.00824422	0.00000000003449594	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Discovery	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	815	1	70	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-	-	0.0000000000345	-	25249537_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0542885	0.0082444	0.0000000000470673	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0534425	0.00824477	0.00000000009341548	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0534399	0.00824477	0.00000000009361047	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0529623	0.00824498	0.0000000001372111	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0528401	0.00824504	0.0000000001512328	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.009	0.0014	0.00000000017	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0531763	0.00834355	0.0000000001904747	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.189809	0.0305322	0.0000000005194463	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0505578	0.00824601	0.0000000008946767	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.323114	0.0527259	0.000000000908067	None	39706196_Hannah-M.-Smith_bmi_discovery
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-	-	0.00000000108	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0708179	0.0116122	0.00000000109714	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0501444	0.00824618	0.000000001224545	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0509586	0.00839097	0.000000001286223	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0503575	0.00833976	0.000000001595576	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0497907	0.00824633	0.000000001598791	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0497669	0.00824634	0.000000001627587	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg27178407	chr1:9189213	1	9189213	GPR157	Island	1.739718	0.2894	0.00000000185	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0492561	0.00824655	0.000000002384061	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0491778	0.00824658	0.000000002526882	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20323445	chr1:9189669	1	9189669	GPR157	Island	-0.01249	0.00201	0.0000000029	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.04885	0.00824671	0.000000003220766	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0485037	0.00824685	0.000000004154693	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0481257	0.008247	0.000000005474699	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0481072	0.00824701	0.000000005549079	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	-0.01066	0.00175	0.0000000057	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0480065	0.00824705	0.000000005970251	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0479592	0.00824707	0.000000006178636	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0476788	0.00824718	0.000000007566614	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0475903	0.00824722	0.000000008064962	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0667416	0.0116371	0.000000009930227	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0468044	0.00816793	0.00000001022453	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0470754	0.00824742	0.00000001165916	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0469809	0.00824745	0.00000001247055	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0468921	0.00824749	0.00000001328166	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0468747	0.0082475	0.00000001344687	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0466424	0.00824759	0.00000001584936	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.046637	0.00824759	0.00000001590953	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-2.6	0.456	0.000000016	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.265824	0.0471745	0.00000001778703	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0470206	0.00836673	0.00000001944885	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0461618	0.00824777	0.00000002221456	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0461613	0.00824777	0.00000002222286	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0459849	0.00824784	0.00000002513421	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0459773	0.00824784	0.00000002526704	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.045848	0.00824789	0.00000002764427	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0456106	0.00824798	0.00000003258654	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	-0.0451613	0.00824815	0.00000004438903	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	0.0027	None	0.000000046	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.161258	0.0295451	0.00000004877151	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.181389	0.033326	0.00000005313952	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0446786	0.00824833	0.00000006167242	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0450709	0.00833008	0.00000006379439	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg27178407	chr1:9189213	1	9189213	GPR157	Island	0.347634	0.0645	0.0000000716	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0447521	0.00833426	0.00000008009325	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.282384	0.0526983	0.00000008498981	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-2.1	0.385	0.000000088	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0441443	0.00824852	0.00000008840413	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0441058	0.00824854	0.00000009070824	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0440853	0.00824854	0.00000009196496	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0440205	0.00824857	0.00000009603534	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0438388	0.00824863	0.0000001084095	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0437879	0.00824865	0.0000001121479	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.279635	0.0528612	0.0000001238195	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0436234	0.00824871	0.0000001250857	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.043483	0.00824876	0.0000001372638	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.0431628	0.00824888	0.0000001694713	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0430347	0.00824892	0.0000001843174	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0447071	0.0086136	0.0000002127706	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0427739	0.00824901	0.0000002184895	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.042758	0.00824902	0.0000002207686	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-0.0414972	0.00801197	0.0000002255507	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14600023	chr1:9189674	1	9189674	GPR157	Island	0.0014	None	0.00000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.042594	0.00824908	0.0000002455669	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18040436	chr1:9189312	1	9189312	GPR157	Island	-0.004	0.00077	0.00000026	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0485552	0.00944589	0.0000002777583	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0423075	0.00824918	0.0000002954703	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0422107	0.00824921	0.0000003144529	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0420948	0.00824925	0.000000338738	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0420615	0.00824926	0.0000003460358	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0417751	0.00824936	0.0000004154517	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0416676	0.0082494	0.0000004448227	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.00091	0.00018	0.00000048	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.00069417	0.00013724	0.000000498	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	-0.041361	0.00824951	0.0000005400002	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0413424	0.00824951	0.0000005463838	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0411945	0.00824956	0.0000005996463	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0411194	0.00824959	0.000000628591	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0528562	0.010605	0.0000006296039	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0410253	0.00824962	0.000000666738	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-0.0407726	0.00824971	0.0000007805504	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0453976	0.00919098	0.0000007924067	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0406963	0.00824973	0.0000008184343	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0410859	0.00835066	0.0000008744819	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0570633	0.0116109	0.0000008991222	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.037	0.008	0.00000092	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0405016	0.0082498	0.0000009233392	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0042	0.00085	0.00000097	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.0404122	0.00824983	0.0000009757605	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0403963	0.00824983	0.0000009853737	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0403917	0.00824983	0.0000009881558	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.04	0.00818	0.000001	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	0.0047	0.00096	0.000001	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0403312	0.00824985	0.000001025662	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-0.0420206	0.00864894	0.000001195214	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0400354	0.00824995	0.000001229765	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0426339	0.00880268	0.000001290126	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	0.0044	0.00091	0.0000013	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0398427	0.00825002	0.000001383227	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.232953	0.0483807	0.000001484456	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18131499	chr1:9189322	1	9189322	GPR157	Island	-0.0023	0.00047	0.0000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NT5C3L protein levels (SeqId = 19135-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NT5C3L protein levels (SeqId = 19135-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 7-methylguanosine phosphate-specific 5'-nucleotidase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-1	0.208	0.0000016	None	Gadd-DA_nt5c3l_protein_levels__seqid___19135-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0395657	0.00825011	0.000001636356	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.0395045	0.00825013	0.000001697953	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.039427	0.00825015	0.000001779229	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14600023	chr1:9189674	1	9189674	GPR157	Island	0.00039	None	0.0000018	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0393073	0.00825019	0.00000191225	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0421429	0.00886498	0.000002014603	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0392119	0.00825022	0.00000202497	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0391589	0.00825024	0.000002090331	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0395305	0.00833397	0.000002122502	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0549418	0.0116048	0.000002217709	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	0.173963	0.0367688	0.000002247993	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.041863	0.00885423	0.000002288323	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.932143	0.1973	0.0000023	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0416528	0.00884985	0.00000254169	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg18131499	chr1:9189322	1	9189322	GPR157	Island	-0.991788	0.2108	0.00000255	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0387568	0.00823651	0.000002555719	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0450422	0.0096282	0.000002920607	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0385868	0.00825042	0.000002937694	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0383542	0.0082505	0.000003369123	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0382802	0.00825052	0.000003518748	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-0.0381407	0.00825056	0.000003818329	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0494324	0.0107036	0.000003901968	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0380911	0.00825058	0.000003930383	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0420671	0.00913149	0.000004123243	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0380029	0.00825061	0.000004138035	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	0.0379852	0.00825061	0.000004180834	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0536539	0.0116716	0.000004322622	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0866533	0.0188625	0.00000438559	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	None	None	0.0000044	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0378337	0.00825066	0.000004565634	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.210126	0.0458698	0.000004659733	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-0.031	0.00668	0.0000048	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0376447	0.00825072	0.000005093554	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GMPR2 protein levels (SeqId = 19446-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GMPR2 protein levels (SeqId = 19446-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GMP reductase 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.95	0.208	0.0000052	None	Gadd-DA_gmpr2_protein_levels__seqid___19446-1__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	0.0015	None	0.0000055	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0375037	0.00825076	0.000005524774	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0374842	0.00825077	0.00000558723	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0374359	0.00825078	0.000005744257	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	0.00348	0.00075	0.0000059	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0377475	0.00833452	0.000005971413	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0373413	0.00825081	0.000006064721	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00713252	chr1:9188947	1	9188947	GPR157	Island	0.0371734	0.00825086	0.000006676003	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0371397	0.00825181	0.000006822036	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PILRA protein levels (SeqId = 8825-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PILRA protein levels (SeqId = 8825-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Paired immunoglobulin-like type 2 receptor alpha	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.94	0.209	0.0000069	None	Gadd-DA_pilra_protein_levels__seqid___8825-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COL6A5 protein levels (SeqId = 11155-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL6A5 protein levels (SeqId = 11155-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-5(VI) chain	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.93	0.209	0.0000075	None	Gadd-DA_col6a5_protein_levels__seqid___11155-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0429686	0.00960266	0.000007711191	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ENPP6 protein levels (SeqId = 15579-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENPP6 protein levels (SeqId = 15579-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 6	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.93	0.209	0.0000081	None	Gadd-DA_enpp6_protein_levels__seqid___15579-26__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0065	0.0015	0.0000083	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.036785	0.00825098	0.000008324108	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IMPDH1 protein levels (SeqId = 5229-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IMPDH1 protein levels (SeqId = 5229-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inosine-5'-monophosphate dehydrogenase 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.92	0.208	0.0000084	None	Gadd-DA_impdh1_protein_levels__seqid___5229-90__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0015	None	0.0000085	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0371195	0.00836669	0.000009206449	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0365193	0.00825106	0.000009668407	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	1.057844	0.2392	0.00000979	-	27105112_hiv_infection_discovery
Yousefi P	-	26553366	2015-11-09	Sex	PATO_0000047	-	Additional file 1	DNA methylation	Sex	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord Blood	-	111	1	0	Both	Admixed	cg22622886	chr1:9189641	1	9189641	GPR157	Island	0.56177534	0.1271	0.0000099	-	26553366_sex
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0363444	0.00825112	0.00001066395	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0363304	0.00825112	0.00001074771	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0362962	0.00825113	0.00001095495	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM134B protein levels (SeqId = 8556-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM134B protein levels (SeqId = 8556-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Reticulophagy regulator 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.92	0.209	0.000011	None	Gadd-DA_fam134b_protein_levels__seqid___8556-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0510689	0.0116248	0.00001125283	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0367165	0.00837787	0.00001181066	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	-0.0360106	0.00825122	0.00001284128	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.00087	0.0002	0.000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-	-	0.0000132	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0358669	0.00825126	0.00001390442	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BDH2 protein levels (SeqId = 17329-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDH2 protein levels (SeqId = 17329-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3-hydroxybutyrate dehydrogenase type 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.9	0.207	0.000014	None	Gadd-DA_bdh2_protein_levels__seqid___17329-2__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg20323445	chr1:9189669	1	9189669	GPR157	Island	1.13988	0.2627	0.0000143	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-0.0421228	0.00972319	0.00001486089	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0357347	0.0082513	0.00001495553	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-0.0349932	0.0080856	0.00001515733	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SETD2 protein levels (SeqId = 12647-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SETD2 protein levels (SeqId = 12647-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone-lysine N-methyltransferase SETD2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.9	0.208	0.000016	None	Gadd-DA_setd2_protein_levels__seqid___12647-52__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0355613	0.00825135	0.00001644986	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0498304	0.0115849	0.00001708935	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0354305	0.00825139	0.00001766991	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.035824	0.00834361	0.00001769413	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0358519	0.00835131	0.00001774346	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0353653	0.00825141	0.00001830994	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GOLGA7 protein levels (SeqId = 19174-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GOLGA7 protein levels (SeqId = 19174-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Golgin subfamily A member 7	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.89	0.208	0.000019	None	Gadd-DA_golga7_protein_levels__seqid___19174-141__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUSD1 protein levels (SeqId = 9582-93)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUSD1 protein levels (SeqId = 9582-93)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sushi domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.89	0.209	0.00002	None	Gadd-DA_susd1_protein_levels__seqid___9582-93__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB113 protein levels (SeqId = 13374-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB113 protein levels (SeqId = 13374-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 113	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.891	0.209	0.00002	None	Gadd-DA_defb113_protein_levels__seqid___13374-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0356701	0.00836723	0.00002029004	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.045542	0.0106836	0.0000203155	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0355975	0.00835384	0.00002045912	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0455799	0.0107	0.00002058835	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0387828	0.00910499	0.00002061549	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0409385	0.00961887	0.00002093533	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TCEAL3 protein levels (SeqId = 19112-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TCEAL3 protein levels (SeqId = 19112-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription elongation factor A protein-like 3	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.89	0.209	0.000022	None	Gadd-DA_tceal3_protein_levels__seqid___19112-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0349945	0.00825151	0.00002239075	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0349907	0.00825152	0.00002243659	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	0.034986	0.00825152	0.00002249434	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	APEX1 protein levels (SeqId = 9849-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APEX1 protein levels (SeqId = 9849-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-(apurinic or apyrimidinic site) lyase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.88	0.209	0.000023	None	Gadd-DA_apex1_protein_levels__seqid___9849-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TP53I3 protein levels (SeqId = 17748-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TP53I3 protein levels (SeqId = 17748-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Quinone oxidoreductase PIG3	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.88	0.208	0.000023	None	Gadd-DA_tp53i3_protein_levels__seqid___17748-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0762865	0.0180474	0.00002382651	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CCDC51 protein levels (SeqId = 12790-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCDC51 protein levels (SeqId = 12790-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coiled-coil domain-containing protein 51	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.881	0.208	0.000024	None	Gadd-DA_ccdc51_protein_levels__seqid___12790-10__somascan_protein_measurement
Kazmi N	PACE	31230546	2019-06-24	Preeclampsia	EFO_0000668	Meta analysis unadjusted model	Table S5	DNA methylation	Preeclampsia	Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	3460	6	Infants	Both	Unclear	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0272	0.0064	0.000024	None	31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0348554	0.00825155	0.00002413384	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TRDMT1 protein levels (SeqId = 12635-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRDMT1 protein levels (SeqId = 12635-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: tRNA (cytosine(38)-C(5))-methyltransferase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.88	0.208	0.000025	None	Gadd-DA_trdmt1_protein_levels__seqid___12635-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APBB1 protein levels (SeqId = 12822-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APBB1 protein levels (SeqId = 12822-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.88	0.209	0.000026	None	Gadd-DA_apbb1_protein_levels__seqid___12822-34__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0345788	0.00825163	0.00002799267	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEFF1 protein levels (SeqId = 15641-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEFF1 protein levels (SeqId = 15641-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tomoregulin-1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.872	0.209	0.000029	None	Gadd-DA_tmeff1_protein_levels__seqid___15641-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0344358	0.00825167	0.00003020963	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.078148	0.018752	0.00003098058	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0342967	0.00825171	0.00003252613	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	POLH protein levels (SeqId = 10022-207)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	POLH protein levels (SeqId = 10022-207)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA polymerase eta	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.87	0.21	0.000033	None	Gadd-DA_polh_protein_levels__seqid___10022-207__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.0342416	0.00825173	0.00003348952	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.04434	0.010702	0.00003445003	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	0.0341284	0.00825176	0.00003555548	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.00039	0.000095	0.000036	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.85	0.206	0.000036	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0340542	0.00825178	0.00003697297	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-1.5	0.371	0.000037	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.034044	0.00825179	0.00003717302	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0429613	0.010415	0.00003728901	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0340242	0.00825179	0.00003756105	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0340076	0.0082518	0.00003789133	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0340034	0.0082518	0.00003797634	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MECP2 protein levels (SeqId = 19108-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MECP2 protein levels (SeqId = 19108-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Methyl-CpG-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.86	0.209	0.000038	None	Gadd-DA_mecp2_protein_levels__seqid___19108-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00713252	chr1:9188947	1	9188947	GPR157	Island	0.0339761	0.0082518	0.00003852473	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.033968	0.00825181	0.00003868837	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08644511	chr1:9171147	1	9171147	GPR157	Open sea	-0.0339283	0.00825182	0.00003950417	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IMPDH2 protein levels (SeqId = 5250-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IMPDH2 protein levels (SeqId = 5250-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inosine-5'-monophosphate dehydrogenase 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.86	0.209	0.00004	None	Gadd-DA_impdh2_protein_levels__seqid___5250-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0775365	0.0188725	0.00004005005	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4
Anna Ulrich	None	38184627	Dec 5, 2023	Idiopathic/heritable pulmonary arterial hypertension	None	Discovery	None	DNA methylation	Idiopathic/heritable pulmonary arterial hypertension	Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1655	4	Adults	Both	European	cg03583311	chr1:9187976	1	9187976	GPR157	North shore	-13	3.1	0.000041	None	38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	TBX22 protein levels (SeqId = 11146-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBX22 protein levels (SeqId = 11146-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-box transcription factor TBX22	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.856	0.209	0.000041	None	Gadd-DA_tbx22_protein_levels__seqid___11146-4__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20323445	chr1:9189669	1	9189669	GPR157	Island	0.00099	None	0.000041	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0338223	0.00825185	0.0000417606	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0337472	0.00825187	0.00004343496	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0475764	0.0116342	0.00004349024	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR1A1 protein levels (SeqId = 4192-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR1A1 protein levels (SeqId = 4192-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldo-keto reductase family 1 member A1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.85	0.208	0.000044	None	Gadd-DA_akr1a1_protein_levels__seqid___4192-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0340571	0.00834243	0.00004480957	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	APBB2 protein levels (SeqId = 12753-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APBB2 protein levels (SeqId = 12753-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.851	0.209	0.000045	None	Gadd-DA_apbb2_protein_levels__seqid___12753-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACP1 protein levels (SeqId = 3858-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACP1 protein levels (SeqId = 3858-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low molecular weight phosphotyrosine protein phosphatase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.85	0.209	0.000046	None	Gadd-DA_acp1_protein_levels__seqid___3858-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.0335677	0.00825192	0.00004769259	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0335603	0.00825192	0.00004787807	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	-0.0335271	0.00825193	0.00004871029	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC2L protein levels (SeqId = 8242-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC2L protein levels (SeqId = 8242-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 2 member L	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.85	0.209	0.000049	None	Gadd-DA_clec2l_protein_levels__seqid___8242-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0470866	0.0116034	0.00004974945	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF410 protein levels (SeqId = 12843-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF410 protein levels (SeqId = 12843-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 410	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.208	0.00005	None	Gadd-DA_znf410_protein_levels__seqid___12843-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2F protein levels (SeqId = 18213-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2F protein levels (SeqId = 18213-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NEDD8-conjugating enzyme UBE2F	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.85	0.209	0.00005	None	Gadd-DA_ube2f_protein_levels__seqid___18213-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0334619	0.00825195	0.00005038755	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BAG4 protein levels (SeqId = 12844-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BAG4 protein levels (SeqId = 12844-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BAG family molecular chaperone regulator 4	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.85	0.209	0.000051	None	Gadd-DA_bag4_protein_levels__seqid___12844-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.0334284	0.00825196	0.00005126949	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ASIC4 protein levels (SeqId = 6951-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASIC4 protein levels (SeqId = 6951-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acid-sensing ion channel 4	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.844	0.209	0.000052	None	Gadd-DA_asic4_protein_levels__seqid___6951-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	0.0333704	0.00825197	0.00005283233	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GRAP protein levels (SeqId = 12820-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRAP protein levels (SeqId = 12820-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GRB2-related adapter protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.209	0.000053	None	Gadd-DA_grap_protein_levels__seqid___12820-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	WFDC13 protein levels (SeqId = 9345-436)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WFDC13 protein levels (SeqId = 9345-436)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WAP four-disulfide core domain protein 13	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.208	0.000053	None	Gadd-DA_wfdc13_protein_levels__seqid___9345-436__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19863456	chr1:9186001	1	9186001	GPR157	North shelf	0.0333614	0.00825198	0.00005307854	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.043174	0.0106873	0.00005377704	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.195954	0.0485389	0.00005435986	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0332965	0.00825199	0.0000548861	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PBRM1 protein levels (SeqId = 12518-289)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PBRM1 protein levels (SeqId = 12518-289)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein polybromo-1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.209	0.000056	None	Gadd-DA_pbrm1_protein_levels__seqid___12518-289__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	0.0332229	0.00825201	0.00005700916	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HRASLS2 protein levels (SeqId = 7822-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HRASLS2 protein levels (SeqId = 7822-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: HRAS-like suppressor 2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.209	0.000058	None	Gadd-DA_hrasls2_protein_levels__seqid___7822-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0331739	0.00825203	0.00005846553	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0331635	0.00825203	0.00005877886	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCD5 protein levels (SeqId = 12517-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCD5 protein levels (SeqId = 12517-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Programmed cell death protein 5	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.208	0.000059	None	Gadd-DA_pdcd5_protein_levels__seqid___12517-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGB2 protein levels (SeqId = 12750-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGB2 protein levels (SeqId = 12750-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin beta-2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.84	0.209	0.000059	None	Gadd-DA_itgb2_protein_levels__seqid___12750-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20284891	chr1:9182171	1	9182171	GPR157	Open sea	-0.033129	0.00825204	0.00005983095	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10108591	chr1:9190516	1	9190516	GPR157	South shore	0.18291	0.0455867	0.00006037112	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGF protein levels (SeqId = 16758-96)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGF protein levels (SeqId = 16758-96)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.208	0.000062	None	Gadd-DA_hdgf_protein_levels__seqid___16758-96__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0330355	0.00825206	0.00006277147	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0380015	0.00949689	0.0000632596	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0330187	0.00825207	0.00006331454	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CTGF protein levels (SeqId = 2975-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTGF protein levels (SeqId = 2975-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Connective tissue growth factor	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.208	0.000064	None	Gadd-DA_ctgf_protein_levels__seqid___2975-19__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14076	1	Adults (18-65y)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.022	0.00548	0.000064	None	Robert-F-Hillary_Incident_COPD_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	LOXL3 protein levels (SeqId = 15427-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LOXL3 protein levels (SeqId = 15427-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysyl oxidase homolog 3	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.209	0.000065	None	Gadd-DA_loxl3_protein_levels__seqid___15427-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TREML1 protein levels (SeqId = 11147-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREML1 protein levels (SeqId = 11147-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trem-like transcript 1 protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.208	0.000065	None	Gadd-DA_treml1_protein_levels__seqid___11147-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SSB protein levels (SeqId = 13526-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SSB protein levels (SeqId = 13526-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lupus La protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.833	0.209	0.000065	None	Gadd-DA_ssb_protein_levels__seqid___13526-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22622886	chr1:9189641	1	9189641	GPR157	Island	-0.0392508	0.00982759	0.00006530167	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0329499	0.00825209	0.00006558214	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST14 protein levels (SeqId = 7262-191)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST14 protein levels (SeqId = 7262-191)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 14	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.209	0.000067	None	Gadd-DA_chst14_protein_levels__seqid___7262-191__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0463196	0.0116154	0.00006701945	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ABHD12 protein levels (SeqId = 7825-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ABHD12 protein levels (SeqId = 7825-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysophosphatidylserine lipase ABHD12	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.209	0.000069	None	Gadd-DA_abhd12_protein_levels__seqid___7825-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25003147	chr1:9187683	1	9187683	GPR157	North shore	-0.0333018	0.00836633	0.00006911336	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0328296	0.00825212	0.00006973598	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PDGFD protein levels (SeqId = 9341-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDGFD protein levels (SeqId = 9341-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet-derived growth factor D	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.208	0.00007	None	Gadd-DA_pdgfd_protein_levels__seqid___9341-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	0.0328004	0.00825213	0.00007078079	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PPA1 protein levels (SeqId = 5021-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPA1 protein levels (SeqId = 5021-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inorganic pyrophosphatase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.83	0.209	0.000071	None	Gadd-DA_ppa1_protein_levels__seqid___5021-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	-0.0327638	0.00825214	0.00007211333	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0745407	0.0187888	0.00007304031	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17940013	chr1:9188688	1	9188688	GPR157	Island	-0.0327257	0.00825215	0.00007352255	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.0327257	0.00825215	0.0000735229	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12383675	chr1:9171487	1	9171487	GPR157	Open sea	0.0326916	0.00825216	0.0000748069	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MTRF1L protein levels (SeqId = 11134-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTRF1L protein levels (SeqId = 11134-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptide chain release factor 1-like, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.821	0.208	0.000077	None	Gadd-DA_mtrf1l_protein_levels__seqid___11134-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PMP2 protein levels (SeqId = 15422-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMP2 protein levels (SeqId = 15422-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myelin P2 protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.208	0.000077	None	Gadd-DA_pmp2_protein_levels__seqid___15422-12__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	-0.032612	0.00825218	0.00007788793	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CRIM1 protein levels (SeqId = 8699-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRIM1 protein levels (SeqId = 8699-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich motor neuron 1 protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000078	None	Gadd-DA_crim1_protein_levels__seqid___8699-43__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TREML2 protein levels (SeqId = 5736-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREML2 protein levels (SeqId = 5736-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trem-like transcript 2 protein	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000078	None	Gadd-DA_treml2_protein_levels__seqid___5736-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MRPL32 protein levels (SeqId = 7982-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRPL32 protein levels (SeqId = 7982-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 39S ribosomal protein L32, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000082	None	Gadd-DA_mrpl32_protein_levels__seqid___7982-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PNP protein levels (SeqId = 15435-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNP protein levels (SeqId = 15435-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Purine nucleoside phosphorylase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000082	None	Gadd-DA_pnp_protein_levels__seqid___15435-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OTUB2 protein levels (SeqId = 12493-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OTUB2 protein levels (SeqId = 12493-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin thioesterase OTUB2	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.208	0.000083	None	Gadd-DA_otub2_protein_levels__seqid___12493-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AFAP1L1 protein levels (SeqId = 9889-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AFAP1L1 protein levels (SeqId = 9889-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Actin filament-associated protein 1-like 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.21	0.000084	None	Gadd-DA_afap1l1_protein_levels__seqid___9889-42__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	-0.0339445	0.00863308	0.00008466231	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	BDNF protein levels (SeqId = 2421-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDNF protein levels (SeqId = 2421-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Brain-derived neurotrophic factor	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.818	0.208	0.000085	None	Gadd-DA_bdnf_protein_levels__seqid___2421-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	B3GALTL protein levels (SeqId = 5727-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B3GALTL protein levels (SeqId = 5727-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,3-glucosyltransferase	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000085	None	Gadd-DA_b3galtl_protein_levels__seqid___5727-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SAP30 protein levels (SeqId = 12888-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SAP30 protein levels (SeqId = 12888-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone deacetylase complex subunit SAP30	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000086	None	Gadd-DA_sap30_protein_levels__seqid___12888-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF134 protein levels (SeqId = 12787-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF134 protein levels (SeqId = 12787-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 134	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.21	0.000086	None	Gadd-DA_znf134_protein_levels__seqid___12787-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINB8 protein levels (SeqId = 19130-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINB8 protein levels (SeqId = 19130-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serpin B8	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.209	0.000092	None	Gadd-DA_serpinb8_protein_levels__seqid___19130-81__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14855124	chr1:9180023	1	9180023	GPR157	Open sea	0.0415376	0.0106211	0.00009238668	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	COX5B protein levels (SeqId = 7887-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COX5B protein levels (SeqId = 7887-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytochrome c oxidase subunit 5B, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.82	0.21	0.000094	None	Gadd-DA_cox5b_protein_levels__seqid___7887-57__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16121109	chr1:9165791	1	9165791	GPR157	Open sea	0.0322181	0.00825229	0.00009498076	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FLT1 protein levels (SeqId = 16315-105)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLT1 protein levels (SeqId = 16315-105)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vascular endothelial growth factor receptor 1	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.81	0.209	0.000095	None	Gadd-DA_flt1_protein_levels__seqid___16315-105__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17156765	chr1:9175961	1	9175961	GPR157	Open sea	-0.0328194	0.00840923	0.00009551795	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	EHD4 protein levels (SeqId = 11421-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EHD4 protein levels (SeqId = 11421-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: EH domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.81	0.209	0.000096	None	Gadd-DA_ehd4_protein_levels__seqid___11421-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13358044	chr1:9173270	1	9173270	GPR157	Open sea	0.0321689	0.0082523	0.00009735071	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HDGF protein levels (SeqId = 8953-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDGF protein levels (SeqId = 8953-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatoma-derived growth factor	774	1	Adults (18-65 years)	Both	European	cg12132894	chr1:9189111	1	9189111	GPR157	Island	-0.81	0.209	0.000099	None	Gadd-DA_hdgf_protein_levels__seqid___8953-47__somascan_protein_measurement