author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0028 0.00014 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05463307 chr6:138729779 6 138729779 HEBP2 South shelf -0.0017 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10780112 chr6:138725213 6 138725213 HEBP2 Island 0.00065 0.000072 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0012 0.00012 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21317795 chr6:138725205 6 138725205 HEBP2 Island -0.000074 0.0000071 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.22028 0.00425 3.2e-115 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.15856 0.00361 1.7e-102 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.133707 0.00818244 1.698047e-59 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03863486 chr6:138724410 6 138724410 HEBP2 North shore 0.08999 0.00384 2.1000000000000002e-58 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.123348 0.00819352 7.753084999999999e-51 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.121901 0.008195 1.101398e-49 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.11624 0.0082006 2.621626e-45 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.113391 0.00820332 3.473483e-43 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05463307 chr6:138729779 6 138729779 HEBP2 South shelf 0.04618 0.0027 1.7e-40 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.108993 0.00820738 5.1541e-40 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2927722 (gene symbol: HEBP2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2927722 (gene symbol: HEBP2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03863486 chr6:138724410 6 138724410 HEBP2 North shore None None 6.1e-40 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2927722__gene_symbol__hebp2__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0013 None 7.2e-39 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.102072 0.00821345 2.791263e-35 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0958795 0.00821853 2.606559e-31 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0941343 0.00821991 3.089342e-30 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0930281 0.00822077 1.446115e-29 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.396066 0.0354424 6.794925e-29 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.419587 0.0387393 3.001698e-27 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0857393 0.00822617 2.39342e-25 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0852206 0.00822653 4.636174e-25 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0825751 0.00822837 1.2695060000000001e-23 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0801399 0.00823002 2.4375450000000003e-22 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0014 None 1.4e-21 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.331812 0.0355622 1.178534e-20 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.363743 0.0390246 1.28984e-20 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0757525 0.00823285 4.007138e-20 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0729542 0.00823457 8.947306e-19 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0699641 0.00823634 2.175855e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0682366 0.00823733 1.295121e-16 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.068076 0.00823742 1.525276e-16 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0675859 0.00823769 2.507071e-16 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0672445 0.00823788 3.53688e-16 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0663083 0.0082384 9.006911e-16 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.065718 0.00823872 0.000000000000001613199 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0651065 0.00823905 0.000000000000002934538 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.280273 0.0354785 0.000000000000002960197 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0830816 0.0107516 0.00000000000001169066 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0631603 0.00824009 0.00000000000001900112 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0624537 0.00824045 0.00000000000003692846 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0614734 0.00824096 0.00000000000009171522 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.060992 0.0082412 0.0000000000001426495 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0607641 0.00824131 0.0000000000001756035 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg25649261 chr6:138725556 6 138725556 HEBP2 Island 2.468698 0.3429 0.000000000000607 - 27105112_hiv_infection_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.041 0.00565 0.00000000000068 None Robert-F-Hillary_Incident_COPD_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.273806 0.0389247 0.000000000002078554 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.263301 0.037738 0.000000000003117486 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0572842 0.00824301 0.000000000003822424 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25367318 chr6:138725211 6 138725211 HEBP2 Island 0.0005 0.000072 0.000000000004 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0570237 0.00824314 0.000000000004779928 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0567012 0.00824329 0.000000000006294552 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 1.6 0.229 0.0000000000064 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.042 0.00605 0.0000000000065 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0555225 0.00824384 0.00000000001699963 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0553706 0.0082439 0.00000000001929207 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12850810 chr6:138725007 6 138725007 HEBP2 Island 0.00037 0.000056 0.000000000025 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0550083 0.00824407 0.00000000002605559 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0537741 0.00824463 0.00000000007149671 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0534853 0.00824475 0.00000000009025454 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.223106 0.034429 0.00000000009396571 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0061 0.00094 0.000000000095 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.053205 0.00824488 0.0000000001130287 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2927722 (gene symbol: HEBP2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2927722 (gene symbol: HEBP2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg17388039 chr6:138726184 6 138726184 HEBP2 Island None None 0.00000000012 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2927722__gene_symbol__hebp2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0521216 0.00824535 0.0000000002668216 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0518667 0.00824546 0.0000000003257568 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0516535 0.00824555 0.0000000003846837 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0513967 0.00824566 0.000000000469564 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0505136 0.00824603 0.00000000092527 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0499209 0.00824628 0.000000001449603 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0498559 0.0082463 0.000000001522294 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0650041 0.0107734 0.000000001640357 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0497308 0.00824636 0.000000001672386 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0497282 0.00824636 0.000000001675652 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0496333 0.0082464 0.000000001799128 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03863486 chr6:138724410 6 138724410 HEBP2 North shore 0.0055 0.00091 0.0000000018 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0496219 0.0082464 0.000000001814649 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0488084 0.00824673 0.000000003321118 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0626291 0.0107472 0.000000005744458 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.186033 0.0323902 0.000000009428951 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0471112 0.0082474 0.00000001136549 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17171485 chr6:138725799 6 138725799 HEBP2 Island 0.00022 0.00004 0.000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.070277 0.0125264 0.00000002056386 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0477424 0.00852659 0.00000002191572 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0460582 0.00824781 0.00000002388214 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.223635 0.0407299 0.00000004060394 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10780112 chr6:138725213 6 138725213 HEBP2 Island 0.0025 0.00047 0.000000056 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0444096 0.00824843 0.00000007396801 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0667356 0.0124066 0.00000007603912 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18261461 chr6:138725231 6 138725231 HEBP2 Island -0.000041 0.0000076 0.000000096 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0439023 0.00824861 0.0000001039212 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0438513 0.00824863 0.0000001075124 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0434584 0.00824877 0.0000001395133 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0649813 0.0124038 0.0000001638339 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CST1 protein levels (SeqId = 5459-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST1 protein levels (SeqId = 5459-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-SN 774 1 Adults (18-65 years) Both European cg01808433 chr6:138724723 6 138724723 HEBP2 Island 0.73 0.139 0.00000019 None Gadd-DA_cst1_protein_levels__seqid___5459-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0428737 0.00824898 0.0000002047458 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0428161 0.008249 0.0000002125734 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0428154 0.008249 0.0000002126713 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Cardenas A Project Viva 31300640 Jul 12, 2019 allergic asthma MONDO_0004784 None Supplementary Data 3 DNA methylation allergic asthma Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values None Illumina HumanMethylationEPIC nasal epithelium None 277 1 Children Both Other cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 6.79 1.279 0.00000023 SE manually calculated 31300640_Cardenas-A_allergic_asthma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0426504 0.00824906 0.0000002367417 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0422178 0.00824921 0.0000003130334 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0547709 0.0107306 0.0000003364276 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25367318 chr6:138725211 6 138725211 HEBP2 Island 0.0024 0.00047 0.00000034 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0420375 0.00824927 0.0000003514003 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0521173 0.0102452 0.000000368277 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0634899 0.0124879 0.0000003738731 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.166584 0.033014 0.0000004560533 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0413809 0.0082495 0.0000005332781 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0413731 0.0082495 0.0000005358909 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0411966 0.00824956 0.0000005988424 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0411131 0.00824959 0.0000006310466 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0409585 0.00824964 0.0000006951426 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0559206 0.0113379 0.0000008221313 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.00033201 6.72e-05 0.000000892 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.040515 0.00824979 0.0000009157606 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0528259 0.0107605 0.0000009240887 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2 Cardenas A Project Viva 31300640 Jul 12, 2019 fractional exhaled nitric oxide (FeNO) EFO_0005536 None Supplementary Data 2 DNA methylation fractional exhaled nitric oxide (FeNO) Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values ppb Illumina HumanMethylationEPIC nasal epithelium None 517 1 Children Both Other cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 5.12 1.031 0.00000093 SE manually calculated 31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_ Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 1.2 0.236 0.00000094 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0404524 0.00824981 0.0000009518703 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03863486 chr6:138724410 6 138724410 HEBP2 North shore -0.00066 0.00013 0.00000098 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25649261 chr6:138725556 6 138725556 HEBP2 Island -0.000057 0.000012 0.00000098 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0607277 0.012466 0.00000111923 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0401287 0.00824992 0.00000116151 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0401221 0.00824992 0.000001166259 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0400509 0.00824995 0.000001218196 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0400492 0.00824995 0.000001219485 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0398406 0.00825002 0.000001385021 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0397342 0.00825005 0.000001477559 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0397127 0.00825006 0.00000149695 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0585676 0.0121754 0.000001521696 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg03863486 chr6:138724410 6 138724410 HEBP2 North shore -0.00042959 8.89e-05 0.00000153 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12850810 chr6:138725007 6 138725007 HEBP2 Island 0.0017 0.00037 0.0000018 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -1.2 0.258 0.000002 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0392068 0.00825022 0.000002031114 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0390156 0.00825028 0.000002277326 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0389338 0.00825031 0.000002391075 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.038898 0.00825032 0.000002442589 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0388596 0.00825034 0.000002499104 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05463307 chr6:138729779 6 138729779 HEBP2 South shelf 0.0039 None 0.0000026 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05463307 chr6:138729779 6 138729779 HEBP2 South shelf 0.0011 None 0.0000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0385799 0.00825042 0.000002949773 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0384984 0.00825045 0.00000309499 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0384399 0.00825047 0.000003203677 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea 0.0383963 0.00825048 0.000003286898 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0541663 0.011641 0.000003298924 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0383621 0.00825049 0.000003353634 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.109348 0.0235518 0.000003461617 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0500739 0.010804 0.000003604203 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.162113 0.0350063 0.0000036652 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0382072 0.00825054 0.000003672661 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0493652 0.0107297 0.000004244253 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0379438 0.00825063 0.000004282827 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0378787 0.00825065 0.000004448047 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0378614 0.00825065 0.000004492725 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg05167232 chr6:138725317 6 138725317 HEBP2 Island 1.314847 0.2867 0.0000045 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0377145 0.0082507 0.000004892061 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0376852 0.00825071 0.000004975707 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17388039 chr6:138726184 6 138726184 HEBP2 Island None None 0.0000051 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0376367 0.00825072 0.000005116944 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0375289 0.00825076 0.000005445266 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.158372 0.0349622 0.000005943085 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Sharp GC - 25855720 2015-08-01 Maternal underweight EFO_0005936 Birth Additional file 1 DNA methylation Maternal underweight Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 601 1 0 Both European cg01808433 chr6:138724723 6 138724723 HEBP2 Island 0.01109 0.00245 0.00000597 - 25855720_maternal_underweight_birth Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.052984 0.0117055 0.000006046527 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0373303 0.00825082 0.000006103225 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0370268 0.00825091 0.000007257779 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0370016 0.00825092 0.000007362335 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0367076 0.00825101 0.000008695957 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.181932 0.0410064 0.000009192566 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0364615 0.00825108 0.000009987244 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17171485 chr6:138725799 6 138725799 HEBP2 Island 0.00025 None 0.00001 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0364395 0.00825109 0.00001011133 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.044851 0.0101891 0.00001080921 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.17448 0.0397014 0.00001114984 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0362257 0.00825115 0.00001139466 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0361691 0.00825117 0.00001175956 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0361219 0.00825118 0.00001207191 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.153001 0.0349909 0.00001234927 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg27521250 chr6:138724600 6 138724600 HEBP2 North shore 0.138824 0.031916 0.00001370861 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0358866 0.00825125 0.00001375384 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0358228 0.00825127 0.00001424721 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0039 0.0009 0.000015 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg03863486 chr6:138724410 6 138724410 HEBP2 North shore -0.00044122 0.00010146 0.000015 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0356691 0.00825132 0.00001550521 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0356143 0.00825133 0.00001597895 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0355267 0.00825136 0.00001676474 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0354925 0.00825137 0.00001708192 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.057359 0.0133983 0.00001871838 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01808433 chr6:138724723 6 138724723 HEBP2 Island 0.00449 0.00102 0.000019 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0352942 0.00825143 0.00001903367 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0458843 0.0107482 0.00001975755 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg05463307 chr6:138729779 6 138729779 HEBP2 South shelf -0.0019 0.00043 0.00002 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0351632 0.00825147 0.00002043716 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01808433 chr6:138724723 6 138724723 HEBP2 Island -0.000061 0.000014 0.000021 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0360283 0.0085041 0.00002283324 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0348428 0.00825156 0.00002429825 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0348378 0.00825156 0.00002436454 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0347956 0.00825157 0.00002492298 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0358803 0.00851954 0.0000255168 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0347461 0.00825159 0.00002559443 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0493407 0.0117235 0.00002583752 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.045 0.01062 0.000027 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0475805 0.0113547 0.00002801195 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0344845 0.00825166 0.000029437 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.133994 0.0320845 0.00002976725 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0355875 0.00852146 0.00002981136 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.034446 0.00825167 0.00003004621 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.146325 0.0350727 0.00003033511 None 39706196_Hannah-M.-Smith_body_fat_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.03 0.00713 0.000033 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0485628 0.0117088 0.00003379611 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.137055 0.0330976 0.00003475412 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0341693 0.00825175 0.0000347949 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island 0.0341027 0.00825177 0.00003603935 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0340861 0.00825177 0.00003635621 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.044356 0.0107502 0.00003710766 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0554367 0.0134533 0.00003798369 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03863486 chr6:138724410 6 138724410 HEBP2 North shore None None 0.000038 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0441091 0.0107931 0.00004397191 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.033673 0.00825189 0.00004515018 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0475535 0.0116648 0.0000459289 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17171485 chr6:138725799 6 138725799 HEBP2 Island 0.00071 None 0.000046 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 SLTM protein levels (SeqId = 8320-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLTM protein levels (SeqId = 8320-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SAFB-like transcription modulator 774 1 Adults (18-65 years) Both European cg01808433 chr6:138724723 6 138724723 HEBP2 Island 0.56 0.139 0.000047 None Gadd-DA_sltm_protein_levels__seqid___8320-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0438671 0.0107945 0.00004852063 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0334925 0.00825194 0.00004959211 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 QPCT protein levels (SeqId = 7849-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QPCT protein levels (SeqId = 7849-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaminyl-peptide cyclotransferase 774 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.63 0.156 0.000053 None Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0434756 0.0107563 0.00005329408 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0435502 0.0107774 0.00005351968 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0332355 0.00825201 0.00005664247 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.130684 0.0324801 0.00005758382 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0501817 0.0124928 0.00005927637 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0331124 0.00825204 0.00006034303 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0467346 0.0116585 0.00006137647 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island 0.0330623 0.00825206 0.00006191619 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0330418 0.00825206 0.0000625712 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0466534 0.0116575 0.0000631192 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0329483 0.00825209 0.00006563882 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.0327656 0.00825214 0.00007204641 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15266580 chr6:138725069 6 138725069 HEBP2 Island 0.141731 0.0357314 0.00007319237 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21317795 chr6:138725205 6 138725205 HEBP2 Island 0.0326221 0.00825218 0.0000774887 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore 0.0326083 0.00825218 0.00007803388 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02939918 chr6:138726163 6 138726163 HEBP2 Island -0.0446184 0.011294 0.00007831011 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P13671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P13671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0324863 0.00825221 0.00008299736 P13671 41361833_Josephine_Robertson_P13671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.0461738 0.0117362 0.00008382723 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25753411 chr6:138727287 6 138727287 HEBP2 South shore -0.0424258 0.0107935 0.00008509457 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17388039 chr6:138726184 6 138726184 HEBP2 Island -0.003 0.00076 0.000086 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore -0.0334418 0.00853217 0.00008913572 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SERPINA3 protein levels (SeqId = 2879-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPINA3 protein levels (SeqId = 2879-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1-antichymotrypsin 774 1 Adults (18-65 years) Both European cg21619059 chr6:138724628 6 138724628 HEBP2 Island -0.67 0.17 0.00009 None Gadd-DA_serpina3_protein_levels__seqid___2879-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22053008 chr6:138731376 6 138731376 HEBP2 Open sea -0.0489871 0.0125208 0.00009177174 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15886977 chr6:138726707 6 138726707 HEBP2 South shore 0.128669 0.0329981 0.00009684237 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery