author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.0023 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.014 0.0015 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore -0.0036 0.00028 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0039 0.00038 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0097 0.00034 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.037 0.0019 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore -0.0022 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.0026 0.0002 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0049 0.00028 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.019 0.0018 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island -0.0037 0.00044 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore 0.0018 0.00021 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0018 0.00016 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 0.41974 0.00397 8e-173 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore 0.60196 0.00605 7.400000000000001e-168 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore 0.55346 0.00615 1.4e-159 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore 0.48081 0.00621 2.4e-147 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.51848 0.00679 4.1e-146 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08203284 chr7:27171528 7 27171528 HOXA4 South shore 0.44671 0.00598 2.1e-144 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06888121 chr7:27169068 7 27169068 HOXA4 North shore 0.49357 0.00698 6.3e-140 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15624376 chr7:27171391 7 27171391 HOXA4 South shore 0.50299 0.00754 3.3e-135 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03982801 chr7:27168688 7 27168688 HOXA4 North shore 0.38093 0.00574 6.8e-135 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore 0.44274 0.00721 1.3e-128 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.61773 0.01015 6.4e-128 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.35623 0.00649 9.9e-120 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore - - 7.38e-117 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.3866 0.00742 1.4e-115 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore - - 4.8600000000000006e-110 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.30804 0.00648 1.9e-108 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.27384 0.00606 1.5e-104 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg08203284 chr7:27171528 7 27171528 HOXA4 South shore - - 2.11e-77 - 23526956_clear_cell_renal_carcinoma Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.33188 0.01083 4.4e-76 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06942814 chr7:27170819 7 27170819 HOXA4 South shore 0.243 0.00824 2e-73 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island 0.28603 0.00995 1.1e-71 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island 0.2725 0.00975 9.699999999999999e-70 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.22824 0.00834 2.4e-68 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island 0.20054 0.00733 2.5e-68 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16651126 chr7:27170552 7 27170552 HOXA4 Island 0.2548 0.00943 1.7e-67 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island 0.27248 0.01071 1.3999999999999999e-63 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island 0.30608 0.01224 1.8999999999999998e-62 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore - - 3.67e-62 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore 0.22892 0.00925 8.899999999999999e-62 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02022102 chr7:27168609 7 27168609 HOXA4 North shore 0.10039 0.00415 2.2000000000000002e-60 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.2275 0.00952 1.5e-59 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore 0.18617 0.0078 1.6000000000000002e-59 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03724423 chr7:27170755 7 27170755 HOXA4 South shore 0.19183 0.00816 1.6e-58 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08203284 chr7:27171528 7 27171528 HOXA4 South shore 0.0012 None 5.9e-57 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04321618 chr7:27170880 7 27170880 HOXA4 South shore 0.17218 0.00759 2.2e-56 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore - - 3.4099999999999996e-54 - 23526956_clear_cell_renal_carcinoma Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore 0.14609 0.00677 2.1999999999999997e-53 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore - - 6.45e-53 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore 0.16843 0.00798 4.8e-52 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 1.14e-49 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island - - 3.22e-46 - 28056824_age_4_vs_age_0 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg02022102 chr7:27168609 7 27168609 HOXA4 North shore - - 1.6499999999999998e-42 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg15624376 chr7:27171391 7 27171391 HOXA4 South shore - - 9.63e-40 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore - - 8.06e-34 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore - - 1.6300000000000002e-32 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg16651126 chr7:27170552 7 27170552 HOXA4 Island - - 1.8e-29 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island - - 3.51e-29 - 23526956_clear_cell_renal_carcinoma Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore - - 1.04e-28 - 28056824_age_4_vs_age_0 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 1.66e-28 - 23526956_clear_cell_renal_carcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg22997113 chr7:27170241 7 27170241 HOXA4 Island - - 4.21e-26 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg09574499 chr7:27168962 7 27168962 HOXA4 North shore - - 1.13e-25 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg19142026 chr7:27170394 7 27170394 HOXA4 Island - - 1.5e-25 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore 0.0017 None 3.1e-25 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg06888121 chr7:27169068 7 27169068 HOXA4 North shore 1.28092 0.08797 4.79e-25 - 25282492_fetal_vs_adult_liver Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore 0.0025 None 2.1e-24 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg07317062 chr7:27170388 7 27170388 HOXA4 Island - - 8.11e-24 - 24500968_pancreatic_ductal_adenocarcinoma Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg21367811 chr7:27169136 7 27169136 HOXA4 North shore 1.69474 0.12221 9.41e-24 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg09574499 chr7:27168962 7 27168962 HOXA4 North shore 1.72218 0.13072 1.97e-22 - 25282492_fetal_vs_adult_liver Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg25967031 chr7:27171203 7 27171203 HOXA4 South shore - - 1.29e-21 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08203284 chr7:27171528 7 27171528 HOXA4 South shore 0.0036 None 2.2e-21 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg14042889 chr7:27169208 7 27169208 HOXA4 North shore 1.49859 0.12024 4.7e-21 - 25282492_fetal_vs_adult_liver Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island - - 7.18e-21 - 28056824_age_4_vs_age_0 Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg14042889 chr7:27169208 7 27169208 HOXA4 North shore - - 1.77e-20 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg14359292 chr7:27170892 7 27170892 HOXA4 South shore - - 2.05e-20 - 24500968_pancreatic_ductal_adenocarcinoma Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 7.7e-20 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg04317399 chr7:27170313 7 27170313 HOXA4 Island - - 2.93e-18 - 24500968_pancreatic_ductal_adenocarcinoma Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11410718 chr7:27170412 7 27170412 HOXA4 Island None None 3.7e-18 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg21367811 chr7:27169136 7 27169136 HOXA4 North shore - - 4.88e-18 - 24500968_pancreatic_ductal_adenocarcinoma Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg06942814 chr7:27170819 7 27170819 HOXA4 South shore -1.62556 0.15366 2.69e-17 - 25282492_fetal_vs_adult_liver Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg07317062 chr7:27170388 7 27170388 HOXA4 Island None None 7.1e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.0017 0.0002 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg14359292 chr7:27170892 7 27170892 HOXA4 South shore None None 3.3e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg24169822 chr7:27170994 7 27170994 HOXA4 South shore None None 4.9e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg17457637 chr7:27170717 7 27170717 HOXA4 South shore None None 8.1e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg19142026 chr7:27170394 7 27170394 HOXA4 Island None None 0.0000000000000019 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg11410718 chr7:27170412 7 27170412 HOXA4 Island - - 0.00000000000000396 - 24500968_pancreatic_ductal_adenocarcinoma Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.4580091 0.058329 0.000000000000004089 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg25952581 chr7:27170961 7 27170961 HOXA4 South shore None None 0.0000000000000043 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.0073 0.0008 0.0000000000000052 None 33564054_Kashima-K_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.011 0.0014 0.00000000000002 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg22997113 chr7:27170241 7 27170241 HOXA4 Island None None 0.000000000000051 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg20161965 chr7:27171401 7 27171401 HOXA4 South shore 0.0045 0.00053 0.000000000000068 None 33564054_Kashima-K_gestational_age Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg22997113 chr7:27170241 7 27170241 HOXA4 Island -1.27356 0.14456 0.00000000000011 - 25282492_fetal_vs_adult_liver Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06942814 chr7:27170819 7 27170819 HOXA4 South shore 0.0016 0.00021 0.00000000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 0.000000000000158 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.0017 0.00023 0.00000000000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.019 0.0026 0.00000000000026 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg06942814 chr7:27170819 7 27170819 HOXA4 South shore None None 0.00000000000091 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg16651126 chr7:27170552 7 27170552 HOXA4 Island None None 0.0000000000038 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore 0.008 None 0.0000000000066 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg04321618 chr7:27170880 7 27170880 HOXA4 South shore None None 0.0000000000087 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0074 0.0011 0.000000000013 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore 0.4819438 0.0715413 0.00000000001622 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0556972 0.00829575 0.00000000001963967 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.055266 0.00824395 0.00000000002104545 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 0.0550388 0.00824406 0.00000000002540694 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore 0.0053 None 0.000000000028 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg04317399 chr7:27170313 7 27170313 HOXA4 Island None None 0.000000000037 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore -0.009 0.0014 0.000000000076 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore 0.0529624 0.00824498 0.0000000001371952 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg06888121 chr7:27169068 7 27169068 HOXA4 North shore -1.604004 0.2503 0.000000000148 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06888121 chr7:27169068 7 27169068 HOXA4 North shore 0.0015 None 0.00000000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0523505 0.00824525 0.0000000002228484 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03982801 chr7:27168688 7 27168688 HOXA4 North shore -0.00052 0.000082 0.00000000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0054 0.00079 0.00000000048 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0496455 0.00799695 0.0000000005509101 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.07 0.011 0.00000000062 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.011 0.0016 0.0000000013 None 33564054_Kashima-K_gestational_age Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg15624376 chr7:27171391 7 27171391 HOXA4 South shore 0.0034 0.00052 0.0000000013 None 33564054_Kashima-K_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0098 0.0016 0.0000000016 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0493603 0.00824651 0.000000002206136 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.0943323 0.0157712 0.000000002254742 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.00056114 9.37e-05 0.00000000287 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Koestler DC - 23868178 2013-07-19 Right vs left colon adenomas EFO_0005406 Basic model Table S1 DNA methylation Right vs left colon adenomas Age and sex Beta values - Illumina HumanMethylation450 Colon adenoma Methylation beta values were logit transformed prior to analysis 135 1 60 Both None cg08203284 chr7:27171528 7 27171528 HOXA4 South shore -0.67 0.1141 0.00000000425 - 23868178_right_vs_left_colon_adenomas_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0479446 0.00831255 0.000000008196617 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore -0.00085 0.00015 0.0000000085 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore -0.0094 0.0016 0.000000011 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore 0.0015 0.00026 0.000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16651126 chr7:27170552 7 27170552 HOXA4 Island 0.0026 None 0.000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore 0.0034 None 0.000000019 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore -0.0013 0.00024 0.000000022 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0472846 0.00851448 0.00000002849861 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island 0.0018 None 0.000000029 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0456732 0.00824796 0.00000003120689 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore -0.0083 0.0015 0.000000035 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore 0.031 0.006 0.000000038 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.00453 0.00082 0.000000039 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore 0.039 0.007 0.000000041 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg16651126 chr7:27170552 7 27170552 HOXA4 Island 0.076 0.014 0.000000043 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.0451705 0.00824814 0.00000004410863 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Bozack PRISM 34569420 Oct 22, 2021 Infant sex PATO_0001894 Placenta Supplementary table 9 DNA methylation Infant sex Cell composition (reference free), Batch effects, Ancestry (genomic PCs) M values None Illumina HumanMethylation450 Placenta None 229 1 Infants Both European, African, Other cg02706018 chr7:27168780 7 27168780 HOXA4 North shore None None 0.000000045 None 34569420_Bozack_infant_sex_placenta Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 8.2 None 0.000000046 None 34044884_Inkster-A_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore 0.0017 None 0.000000047 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0449179 0.00824824 0.0000000524154 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.0092 0.0017 0.000000055 - 27651444_smoking_current_vs_never_smoking Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.00922 0.0017 0.000000055 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0448188 0.00824827 0.00000005607115 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island - - 0.000000057 - 26500701_sex_kora_f4 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore -1.634902 0.3017 0.00000006 - 27105112_hiv_infection_discovery Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg03724423 chr7:27170755 7 27170755 HOXA4 South shore 0.042 0.008 0.000000066 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore 0.001 None 0.000000086 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.021 0.00386 0.000000097 None Robert-F-Hillary_Incident_COPD_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.192087 0.0360334 0.00000009901065 None 39706196_Hannah-M.-Smith_bmi_discovery Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg02022102 chr7:27168609 7 27168609 HOXA4 North shore -0.00895 0.0017 0.000000104 - 23334450_rheumatoid_arthritis Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.00100363 0.00018773 0.00000011 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0437762 0.00824866 0.0000001130248 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08657492 chr7:27170832 7 27170832 HOXA4 South shore None None 0.00000012 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore 0.0018 None 0.00000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.00086827 0.00016297 0.000000121 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14359292 chr7:27170892 7 27170892 HOXA4 South shore None None 0.00000016 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Zhang L ROSMAP, Mt. Sinai, London, Gasparoni 33902726 04-26-2021 Braak stage EFO_0000249 Males Table S3 DNA methylation Braak stage Age, Cell composition (reference based), Batch effects, M values None Illumina HumanMethylation450 Prefrontal cortex None 388 4 Geriatrics Males Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.17 0.033 0.00000017 None 33902726_Zhang-L_braak_stage_males Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25952581 chr7:27170961 7 27170961 HOXA4 South shore None None 0.00000017 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0420171 0.00807136 0.0000001958761 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0428941 0.00824897 0.0000002020385 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg03724423 chr7:27170755 7 27170755 HOXA4 South shore 0.3632012 0.0700435 0.0000002156 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06888121 chr7:27169068 7 27169068 HOXA4 North shore -0.0011 0.00021 0.00000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08657492 chr7:27170832 7 27170832 HOXA4 South shore None None 0.00000023 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island -0.0015 0.00028 0.00000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25952581 chr7:27170961 7 27170961 HOXA4 South shore None None 0.00000023 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg20171892 chr7:27169584 7 27169584 HOXA4 Island -0.2052554 0.0399537 0.0000002787 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg08203284 chr7:27171528 7 27171528 HOXA4 South shore 0.0012 0.00023 0.00000028 None 33564054_Kashima-K_gestational_age Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island 0.055 0.011 0.00000029 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore 0.0021 None 0.00000029 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0422429 0.0082492 0.000000308018 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24169822 chr7:27170994 7 27170994 HOXA4 South shore None None 0.00000031 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island -0.0011 0.00021 0.00000032 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0421274 0.00824924 0.0000003317254 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island 0.074 0.015 0.00000036 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17591595 chr7:27171051 7 27171051 HOXA4 South shore None None 0.00000037 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.00053151 0.00010431 0.000000412 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0416653 0.0082494 0.0000004454757 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06942814 chr7:27170819 7 27170819 HOXA4 South shore None None 0.00000045 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0416011 0.00824942 0.0000004639709 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 0.0415145 0.00824945 0.0000004901265 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.0414745 0.00824947 0.0000005026722 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore -0.3156007 0.0628254 0.0000005075 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0413463 0.00824951 0.000000545033 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24169822 chr7:27170994 7 27170994 HOXA4 South shore None None 0.00000056 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08657492 chr7:27170832 7 27170832 HOXA4 South shore None None 0.00000062 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island - - 0.000000632 - 26500701_sex_kora_f4 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.032 0.007 0.00000064 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island - - 0.000000642 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0410193 0.00824962 0.0000006692135 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0409963 0.00824963 0.0000006789304 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island -0.174181 0.0350621 0.0000006833858 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.016 0.00332 0.00000071 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore -1.542154 0.3112 0.00000072 - 27105112_hiv_infection_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06942814 chr7:27170819 7 27170819 HOXA4 South shore None None 0.00000073 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0408273 0.00824969 0.0000007544255 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0407995 0.0082497 0.0000007675722 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06942814 chr7:27170819 7 27170819 HOXA4 South shore None None 0.00000085 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0405994 0.00824976 0.0000008691369 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg23884241 chr7:27169957 7 27169957 HOXA4 Island None None 0.00000087 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0400004 0.00816087 0.0000009613016 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg23884241 chr7:27169957 7 27169957 HOXA4 Island None None 0.000001 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore 0.0404165 0.00827137 0.000001038238 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg03982801 chr7:27168688 7 27168688 HOXA4 North shore 5.1 None 0.0000011 None 34044884_Inkster-A_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04321618 chr7:27170880 7 27170880 HOXA4 South shore 0.0018 None 0.0000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03724423 chr7:27170755 7 27170755 HOXA4 South shore None None 0.0000013 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg21367811 chr7:27169136 7 27169136 HOXA4 North shore 0.033 0.007 0.0000013 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25952581 chr7:27170961 7 27170961 HOXA4 South shore None None 0.0000013 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0399146 0.00824999 0.000001323905 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.039524 0.00816935 0.000001324278 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0047 0.001 0.0000014 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0398193 0.00825002 0.000001403047 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03724423 chr7:27170755 7 27170755 HOXA4 South shore None None 0.0000015 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03724423 chr7:27170755 7 27170755 HOXA4 South shore None None 0.0000016 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0408495 0.0085306 0.000001696043 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24169822 chr7:27170994 7 27170994 HOXA4 South shore None None 0.0000017 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg04321618 chr7:27170880 7 27170880 HOXA4 South shore None None 0.0000018 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.0034 None 0.0000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.3451247 0.0724283 0.000001888 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14359292 chr7:27170892 7 27170892 HOXA4 South shore None None 0.0000019 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg04321618 chr7:27170880 7 27170880 HOXA4 South shore None None 0.000002 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08203284 chr7:27171528 7 27171528 HOXA4 South shore -0.0005 0.00011 0.000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0389593 0.00819746 0.000002027137 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19142026 chr7:27170394 7 27170394 HOXA4 Island None None 0.0000022 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island -0.0390704 0.00825027 0.0000022039 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0390254 0.00825028 0.000002263961 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore - - 0.00000228 - 26500701_sex_kora_f4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore - - 0.00000232 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0377954 0.00800903 0.000002390846 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.017 0.00372 0.0000028 None Robert-F-Hillary_Incident_COPD_Basic_model Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg16651126 chr7:27170552 7 27170552 HOXA4 Island - - 0.0000029 - 26500701_sex_kora_f4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14359292 chr7:27170892 7 27170892 HOXA4 South shore - - 0.0000032 - 26500701_sex_kora_f4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14359292 chr7:27170892 7 27170892 HOXA4 South shore None None 0.0000034 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0380612 0.0082243 0.000003725659 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore -0.0381128 0.00825057 0.000003880939 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 3.9 None 0.000004 None 34044884_Inkster-A_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.0379303 0.00823273 0.00000411437 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0379518 0.00825062 0.000004262982 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0379003 0.00825064 0.000004392495 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0378599 0.00825065 0.000004496649 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore 0.0022 None 0.0000045 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 0.0378417 0.00825066 0.000004544491 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore None None 0.0000046 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.037903 0.00829329 0.000004909418 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg22997113 chr7:27170241 7 27170241 HOXA4 Island 3.7 None 0.000005 None 34044884_Inkster-A_sex_discovery Cardenas A Project Viva 31300640 Jul 12, 2019 Bronchodilator Response (BDR) GO_0097366 None Supplementary Data 4 DNA methylation Bronchodilator Response (BDR) Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values % change in FEV1 Illumina HumanMethylationEPIC nasal epithelium None 454 1 Children Both Other cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.14 0.0304 0.0000053 SE manually calculated 31300640_Cardenas-A_bronchodilator_response__bdr_ Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island 0.0027 None 0.0000058 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore 0.025 0.005 0.0000058 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0373018 0.00825083 0.000006203727 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0372972 0.00825083 0.00000621993 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.00447 0.00099 0.0000064 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore 0.034 0.007 0.0000068 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0371156 0.00825088 0.00000689998 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0019 0.00041 0.0000071 None 33450751_Mulder-RH_age_sex_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg04321618 chr7:27170880 7 27170880 HOXA4 South shore None None 0.0000072 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11015251 chr7:27170554 7 27170554 HOXA4 Island None None 0.0000074 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0369701 0.00825093 0.00000749534 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island -0.0368315 0.00826264 0.000008349868 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore - - 0.00000858 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04317399 chr7:27170313 7 27170313 HOXA4 Island -0.0367649 0.00826382 0.000008694687 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.0011 0.00024 0.0000088 None 33450751_Mulder-RH_age_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0366067 0.00823811 0.000008912555 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg04321618 chr7:27170880 7 27170880 HOXA4 South shore - - 0.00000933 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0473214 0.0107046 0.000009896271 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg04321618 chr7:27170880 7 27170880 HOXA4 South shore 3.1 None 0.00001 None 34044884_Inkster-A_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04321618 chr7:27170880 7 27170880 HOXA4 South shore -0.006 0.0014 0.00001 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Koestler DC - 23868178 2013-07-19 Right vs left colon adenomas EFO_0005406 Fully adjusted model Table S1 DNA methylation Right vs left colon adenomas Age, sex, smoking status, colon polyp size and alcohol consumption Beta values - Illumina HumanMethylation450 Colon adenomas Methylation beta values were logit transformed prior to analysis 135 1 60 Both None cg08203284 chr7:27171528 7 27171528 HOXA4 South shore -0.67 0.1519 0.0000103 - 23868178_right_vs_left_colon_adenomas_fully_adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0367369 0.00832807 0.00001035281 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.036657 0.00831146 0.00001039056 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.0363885 0.0082511 0.00001040377 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.0363669 0.00825111 0.00001053069 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island -0.0362966 0.00825113 0.00001095226 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.0362747 0.00825114 0.00001108694 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.0362501 0.00825114 0.00001124022 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore 0.0358871 0.00818818 0.00001179794 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore 0.0361566 0.00825117 0.00001184147 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island -0.0361368 0.00825118 0.0000119726 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06888121 chr7:27169068 7 27169068 HOXA4 North shore 0.0045 None 0.000012 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.032 0.00739 0.000012 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.157803 0.0361257 0.00001260203 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.0359988 0.00825122 0.00001292564 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.027 0.006 0.000013 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14042889 chr7:27169208 7 27169208 HOXA4 North shore -0.0051 0.0012 0.000013 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Zhang L ROSMAP, Mt. Sinai, London, Gasparoni 33902726 04-26-2021 Braak stage EFO_0000249 Females Table S3 DNA methylation Braak stage Age, Cell composition (reference based), Batch effects, M values None Illumina HumanMethylation450 Prefrontal cortex None 642 4 Geriatrics Females Unclear cg16651126 chr7:27170552 7 27170552 HOXA4 Island 0.13 0.03 0.000013 None 33902726_Zhang-L_braak_stage_females Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19142026 chr7:27170394 7 27170394 HOXA4 Island None None 0.000013 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.035954 0.00825123 0.00001325057 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore -0.0077 0.0018 0.000015 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg06942814 chr7:27170819 7 27170819 HOXA4 South shore 2.7 None 0.000016 None 34044884_Inkster-A_sex_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0098 0.00226 0.000016 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.04 0.009 0.000017 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22997113 chr7:27170241 7 27170241 HOXA4 Island 0.0349287 0.00816199 0.00001885557 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11015251 chr7:27170554 7 27170554 HOXA4 Island None None 0.000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11015251 chr7:27170554 7 27170554 HOXA4 Island None None 0.000019 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.026 0.006 0.00002 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16651126 chr7:27170552 7 27170552 HOXA4 Island None None 0.00002 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0351928 0.00825146 0.00002011156 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0351813 0.00825146 0.00002023808 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15624376 chr7:27171391 7 27171391 HOXA4 South shore 0.0365215 0.00856769 0.00002032417 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg11227540 chr7:27169510 7 27169510 HOXA4 North shore -0.1559165 0.0366101 0.00002055 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0342337 0.00807992 0.00002280229 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0349402 0.00825153 0.00002305698 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.035279 0.00834352 0.00002368757 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Zhang L ROSMAP, Mt. Sinai, London, Gasparoni 33902726 04-26-2021 Braak stage EFO_0000249 Females Table S3 DNA methylation Braak stage Age, Cell composition (reference based), Batch effects, M values None Illumina HumanMethylation450 Prefrontal cortex None 642 4 Geriatrics Females Unclear cg11015251 chr7:27170554 7 27170554 HOXA4 Island 0.128 0.03 0.000024 None 33902726_Zhang-L_braak_stage_females Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island - - 0.0000244 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0348311 0.00825156 0.00002445152 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.0349815 0.00828859 0.00002452941 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island -0.0347748 0.00824554 0.00002486072 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore -0.0349529 0.00829367 0.00002519367 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17457637 chr7:27170717 7 27170717 HOXA4 South shore None None 0.000026 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island -0.034651 0.00824513 0.00002654248 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore -0.0348308 0.00829308 0.00002685121 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11227540 chr7:27169510 7 27169510 HOXA4 North shore -0.0346511 0.00825161 0.00002693084 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore 0.023 0.005 0.000027 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0346302 0.00825162 0.0000272342 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0348777 0.00831343 0.00002740596 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore - - 0.0000279 - 26500701_sex_kora_f4 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.024 0.006 0.000028 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02022102 chr7:27168609 7 27168609 HOXA4 North shore 0.17892 0.0427582 0.00002872694 None 39706196_Hannah-M.-Smith_bmi_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg23884241 chr7:27169957 7 27169957 HOXA4 Island None None 0.00003 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.03449 0.00828689 0.00003172837 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02706018 chr7:27168780 7 27168780 HOXA4 North shore 0.0343344 0.0082517 0.0000318824 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0345576 0.00831148 0.00003231394 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0346048 0.00832347 0.00003235801 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore -0.0342233 0.00824041 0.00003298451 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.0345075 0.00831948 0.00003375761 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore 0.005 None 0.000034 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.0343794 0.00829443 0.00003419105 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore -0.0341493 0.00824142 0.00003437901 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore -0.0341098 0.00825177 0.00003590452 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09574499 chr7:27168962 7 27168962 HOXA4 North shore 0.011 0.0026 0.000036 None 33450751_Mulder-RH_sex_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17591595 chr7:27171051 7 27171051 HOXA4 South shore None None 0.000037 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19142026 chr7:27170394 7 27170394 HOXA4 Island None None 0.000037 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.0339474 0.00824729 0.0000387298 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15624376 chr7:27171391 7 27171391 HOXA4 South shore -0.0049 0.0012 0.000039 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.0332662 0.00809053 0.00003948246 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0338797 0.0082404 0.00003953905 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island 0.033892 0.00825183 0.00004026459 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0340597 0.00829692 0.00004063243 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03724423 chr7:27170755 7 27170755 HOXA4 South shore 0.0015 None 0.000043 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island 0.0024 None 0.000043 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17591595 chr7:27171051 7 27171051 HOXA4 South shore None None 0.000044 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island -0.0336141 0.00823911 0.00004530954 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16651126 chr7:27170552 7 27170552 HOXA4 Island None None 0.000046 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island -0.0335504 0.00823932 0.00004685918 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island -0.0335786 0.00825192 0.00004742393 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island -0.0335486 0.00825192 0.0000481701 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore -0.0335167 0.00825193 0.00004897523 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0335108 0.00825193 0.000049125 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0336783 0.00830058 0.00004989 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0334541 0.00825195 0.00005059131 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 COL18A1 protein levels (SeqId = 2201-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL18A1 protein levels (SeqId = 2201-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(XVIII) chain 774 1 Adults (18-65 years) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island -0.31 0.077 0.000051 None Gadd-DA_col18a1_protein_levels__seqid___2201-17__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0333945 0.00825197 0.00005217791 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore 0.0333525 0.00825198 0.0000533218 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.0333307 0.00825198 0.00005392645 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20161965 chr7:27171401 7 27171401 HOXA4 South shore -0.001 0.00025 0.000054 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.033299 0.00825199 0.00005481763 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0335578 0.0083189 0.00005513305 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.0335413 0.00832439 0.0000562317 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore 0.0334875 0.00831931 0.00005719625 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore -0.0332044 0.00825202 0.00005755489 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island -0.0078 0.0019 0.000058 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.033167 0.00825203 0.00005867528 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17457637 chr7:27170717 7 27170717 HOXA4 South shore -0.0331541 0.00825203 0.00005906377 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore -0.0331497 0.00825203 0.00005919897 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0334366 0.00832649 0.0000595662 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island -0.0330589 0.00823467 0.00005984394 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17457637 chr7:27170717 7 27170717 HOXA4 South shore None None 0.00006 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0329937 0.00822444 0.00006059168 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg03724423 chr7:27170755 7 27170755 HOXA4 South shore - - 0.0000606 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg20171892 chr7:27169584 7 27169584 HOXA4 Island -0.132749 0.0331084 0.00006108003 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0327089 0.00816655 0.00006226448 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore -0.0331204 0.00827236 0.00006265404 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg11410718 chr7:27170412 7 27170412 HOXA4 Island 1.3 None 0.000064 None 34044884_Inkster-A_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.0329897 0.00825208 0.00006426213 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25952581 chr7:27170961 7 27170961 HOXA4 South shore -0.0329905 0.00825649 0.00006481572 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07317062 chr7:27170388 7 27170388 HOXA4 Island -0.008 0.002 0.000065 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0086 0.0021 0.000065 - 27651444_smoking_current_vs_never_smoking Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island -0.0089 0.0022 0.000065 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg00562553 chr7:27169740 7 27169740 HOXA4 Island 0.014 0.00353 0.000066 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg24169822 chr7:27170994 7 27170994 HOXA4 South shore - - 0.0000687 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island -0.0327898 0.00823991 0.00006942712 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19142026 chr7:27170394 7 27170394 HOXA4 Island -0.0327769 0.00823923 0.00006978724 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11410718 chr7:27170412 7 27170412 HOXA4 Island 0.0327807 0.00825213 0.00007149543 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg17457637 chr7:27170717 7 27170717 HOXA4 South shore None None 0.000072 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15196806 chr7:27171213 7 27171213 HOXA4 South shore 0.0327255 0.00825215 0.00007352965 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg17132446 chr7:27169342 7 27169342 HOXA4 North shore 0.11125 0.0280548 0.00007353443 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore 0.0324034 0.00817225 0.0000737284 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg08657492 chr7:27170832 7 27170832 HOXA4 South shore -0.0670611 0.0169626 0.000077318 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0325964 0.00825218 0.00007850693 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.8 0.203 0.000079 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.00008 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11015251 chr7:27170554 7 27170554 HOXA4 Island -0.0325395 0.00824741 0.00008002885 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.0314951 0.00798442 0.00008031425 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CLEC11A protein levels (SeqId = 4500-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLEC11A protein levels (SeqId = 4500-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-type lectin domain family 11 member A 774 1 Adults (18-65 years) Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island -0.44 0.113 0.000081 None Gadd-DA_clec11a_protein_levels__seqid___4500-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0325326 0.0082522 0.00008108008 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore -0.0327239 0.00830836 0.00008231532 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09799676 chr7:27169586 7 27169586 HOXA4 Island 0.0324517 0.00825617 0.00008512172 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.000086 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11227540 chr7:27169510 7 27169510 HOXA4 North shore -0.032311 0.00822602 0.00008608215 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island 0.0320919 0.00817208 0.00008639879 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg23884241 chr7:27169957 7 27169957 HOXA4 Island -0.0881146 0.0224558 0.00008744323 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg00562553 chr7:27169740 7 27169740 HOXA4 Island None None 0.000091 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg11908057 chr7:27171154 7 27171154 HOXA4 South shore -0.0245 0.0063 0.000091 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11908057 chr7:27171154 7 27171154 HOXA4 South shore 0.0322905 0.00825227 0.00009159577 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11227540 chr7:27169510 7 27169510 HOXA4 North shore 0.0998503 0.0255319 0.00009234221 None 39706196_Hannah-M.-Smith_bmi_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg17591595 chr7:27171051 7 27171051 HOXA4 South shore - - 0.0000955 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11227540 chr7:27169510 7 27169510 HOXA4 North shore -0.0968639 0.0248467 0.00009715236 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore 0.0323827 0.00831125 0.00009812857 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25967031 chr7:27171203 7 27171203 HOXA4 South shore -0.0323827 0.00831253 0.00009837129 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2