author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea -0.0018 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08651124 chr1:23519990 1 23519990 HTR1D Open sea -0.00089 0.000048 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11811391 chr1:23520083 1 23520083 HTR1D Open sea -0.0014 0.000068 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20678835 chr1:23521332 1 23521332 HTR1D Open sea 0.0028 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20678835 chr1:23521332 1 23521332 HTR1D Open sea -0.011 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24466277 chr1:23519622 1 23519622 HTR1D Open sea -0.0026 0.00028 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20887241 chr1:23522636 1 23522636 HTR1D Open sea 0.30822 0.00528 1.4000000000000002e-124 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea 0.30744 0.00679 9.799999999999998e-105 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11953164 chr1:23521307 1 23521307 HTR1D Open sea 0.25838 0.0062 2.1e-98 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08872493 chr1:23521417 1 23521417 HTR1D Open sea 0.22728 0.00682 5.8e-82 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20678835 chr1:23521332 1 23521332 HTR1D Open sea 0.14868 0.00476 2.2e-77 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04974804 chr1:23521815 1 23521815 HTR1D Open sea 0.15141 0.00616 2.5e-61 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11811391 chr1:23520083 1 23520083 HTR1D Open sea 0.00078 None 2.9e-54 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea 0.04179 0.00312 2.5e-29 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea 0.00087 None 4.0000000000000003e-28 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11811391 chr1:23520083 1 23520083 HTR1D Open sea 0.0024 None 1.9e-23 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08651124 chr1:23519990 1 23519990 HTR1D Open sea 0.00042 None 3e-21 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24466277 chr1:23519622 1 23519622 HTR1D Open sea 0.0027 None 6.3e-19 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea 0.0717472 0.00823529 3.296223e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08651124 chr1:23519990 1 23519990 HTR1D Open sea 0.0014 None 0.0000000000000034 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea 0.0015 None 0.000000000000008 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15484742 chr1:23519884 1 23519884 HTR1D Open sea 0.0016 0.00021 0.0000000000000082 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea -0.00067 0.000089 0.000000000000037 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea 0.0027 None 0.00000000000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20887241 chr1:23522636 1 23522636 HTR1D Open sea -0.00072 0.00011 0.000000000059 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02052721 chr1:23518539 1 23518539 HTR1D Open sea 0.00071 None 0.00000000042 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24466277 chr1:23519622 1 23519622 HTR1D Open sea 0.0077 None 0.00000000064 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea 0.0488624 0.00824671 0.000000003191389 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea -0.0468859 0.00824749 0.00000001334048 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg11811391 chr1:23520083 1 23520083 HTR1D Open sea -1.487107 0.2645 0.0000000189 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04974804 chr1:23521815 1 23521815 HTR1D Open sea -0.002 0.00039 0.00000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11811391 chr1:23520083 1 23520083 HTR1D Open sea -0.0021 0.00042 0.00000039 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04974804 chr1:23521815 1 23521815 HTR1D Open sea -0.013 0.0025 0.00000056 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.0097 0.002 0.0000014 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.01 0.002 0.00000143 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg20678835 chr1:23521332 1 23521332 HTR1D Open sea 0.077718 0.0166739 0.000003146 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08651124 chr1:23519990 1 23519990 HTR1D Open sea -0.0014 0.00031 0.0000041 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Green BB - 26771251 2016-08-01 Arsenic exposure OBI_0002416 Placenta Table S2 DNA methylation Arsenic exposure Offspring sex, maternal age, gestational age and cell counts Beta values mug/kg Illumina HumanMethylation450 Placenta Arsenic exposure was measured in the placenta 285 1 31.5 Females European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea 0.0033 0.00072 0.0000045 - 26771251_arsenic_exposure_placenta Lu X Lifelines DEEP 32916427 2020-09-09 MiBP None None ST8 DNA methylation MiBP Age, Sex, body mass index, cell composition (reference based), batch effects Beta Values ng/24h Illumina HumanMethylation450 Whole blood The trait is a phthalate metabolite 622 1 Adults Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea -0.0174 0.00383 0.0000057 None 32916427_Lu-X_mibp Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg15484742 chr1:23519884 1 23519884 HTR1D Open sea -0.00054 0.00012 0.0000084 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Gadd DA Generation Scotland 35945220 31/07/2022 BMP1 protein levels (SeqId = 3348-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMP1 protein levels (SeqId = 3348-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein 1 774 1 Adults (18-65 years) Both European cg15484742 chr1:23519884 1 23519884 HTR1D Open sea -0.43 0.096 0.0000085 None Gadd-DA_bmp1_protein_levels__seqid___3348-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea -0.0364941 0.00825107 0.000009805999 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11953164 chr1:23521307 1 23521307 HTR1D Open sea 0.00065 0.00015 0.000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea 0.0042 None 0.000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.009 0.002 0.0000171 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea 0.0348655 0.00825155 0.00002400418 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00023024 chr1:23521272 1 23521272 HTR1D Open sea -0.135253 0.0322302 0.00002724585 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea 0.0344021 0.00825168 0.00003075623 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ALDH5A1 protein levels (SeqId = 17792-158) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH5A1 protein levels (SeqId = 17792-158) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Succinate-semialdehyde dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg15484742 chr1:23519884 1 23519884 HTR1D Open sea -0.4 0.096 0.000032 None Gadd-DA_aldh5a1_protein_levels__seqid___17792-158__somascan_protein_measurement Fragoso-Bargas Nicolas EPIPREG (Epigenetics in pregnancy) 39844050 Jan 22, 2025 Moderate physical activity EFO:0000001 discovery None DNA methylation Moderate physical activity Age,Smoking,Cell composition (reference based) M values hours/day Illumina HumanMethylationEPIC Whole blood analysis of pregnant women (gestational week 28) 353 1 Adults (18-65 years) Females European,South Asian cg08651124 chr1:23519990 1 23519990 HTR1D Open sea 0.04006548 0.009647216 0.0000415 None 39844050_Fragoso-Bargas-Nicolas_moderate_physical_activity_discovery Gadd DA Generation Scotland 35945220 31/07/2022 C16orf54 protein levels (SeqId = 12394-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C16orf54 protein levels (SeqId = 12394-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein C16orf54 774 1 Adults (18-65 years) Both European cg07328145 chr1:23520820 1 23520820 HTR1D Open sea 1.12 0.276 0.000047 None Gadd-DA_c16orf54_protein_levels__seqid___12394-53__somascan_protein_measurement Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg15484742 chr1:23519884 1 23519884 HTR1D Open sea -0.00047 0.00012 0.00005 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Fernandez-Jimenez N Pregnancy And Childhood Epigenetics (PACE) None None maternal pre-pregnancy body mass index EFO_0004340 inverse variance-weighted fixed effects meta-analysis https://doi.org/10.5281/zenodo.7314534 DNA methylation maternal pre-pregnancy body mass index Maternal age, parity, maternal education, maternal smoking Beta values kg/m2 Illumina HumanMethylation450 Placenta None 2631 10 Infants Both European, Unclear cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.00092 0.00023 0.000051 None Fernandez-Jimenez-N_maternal_pre-pregnancy_body_mass_index_inverse_variance-weighted_fixed_effects_meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08651124 chr1:23519990 1 23519990 HTR1D Open sea -0.00422 0.00102 0.000053 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24466277 chr1:23519622 1 23519622 HTR1D Open sea -0.007 0.0017 0.000055 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg21536328 chr1:23522665 1 23522665 HTR1D Open sea -0.132228 0.0327912 0.00005542528 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.0209 0.00506 0.000061 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13270062 chr1:23521688 1 23521688 HTR1D Open sea 0.0329903 0.00825208 0.0000642415 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08872493 chr1:23521417 1 23521417 HTR1D Open sea -0.0082 0.0021 0.00007 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04974804 chr1:23521815 1 23521815 HTR1D Open sea 0.02 0.0051 0.000072 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 PSME2 protein levels (SeqId = 17694-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSME2 protein levels (SeqId = 17694-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteasome activator complex subunit 2 774 1 Adults (18-65 years) Both European cg11953164 chr1:23521307 1 23521307 HTR1D Open sea 0.45 0.115 0.000085 None Gadd-DA_psme2_protein_levels__seqid___17694-32__somascan_protein_measurement