author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.00041	0.000048	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15735287	chr7:155090783	7	155090783	INSIG1	South shore	0.00053	0.000061	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17927917	chr7:155089006	7	155089006	INSIG1	Island	0.00057	0.00005	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.0021	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	0.014	0.0011	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-	-	6.15e-73	-	28056824_age_4_vs_age_0
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	2.87056	0.07721	3.4999999999999995e-55	-	25282492_fetal_vs_adult_liver
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg04811098	chr7:155088454	7	155088454	INSIG1	North shore	2.17962	0.10129	1.34e-36	-	25282492_fetal_vs_adult_liver
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3033209 (gene symbol: INSIG1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3033209 (gene symbol: INSIG1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	None	None	1.1000000000000001e-30	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3033209__gene_symbol__insig1__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04811098	chr7:155088454	7	155088454	INSIG1	North shore	0.05897	0.00474	1.9e-26	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21054968	chr7:155089542	7	155089542	INSIG1	Island	0.00022	None	1.7e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.07795	0.00852	8.3e-17	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12140867	chr7:155100546	7	155100546	INSIG1	Open sea	0.00081	None	0.0000000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg07673263	chr7:155090849	7	155090849	INSIG1	South shore	0.00879	0.0013	0.0000000000116	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15735287	chr7:155090783	7	155090783	INSIG1	South shore	0.0026	0.00039	0.000000000028	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg21528729	chr7:155095191	7	155095191	INSIG1	Open sea	-0.0525	0.00763	0.000000000062	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3033209 (gene symbol: INSIG1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3033209 (gene symbol: INSIG1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg21528729	chr7:155095191	7	155095191	INSIG1	Open sea	None	None	0.000000000063	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3033209__gene_symbol__insig1__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15735287	chr7:155090783	7	155090783	INSIG1	South shore	0.00809	0.00127	0.0000000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.0589	0.00935	0.0000000016	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.000087	0.000015	0.000000003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg04811098	chr7:155088454	7	155088454	INSIG1	North shore	0.25584	0.0432	0.00000000321	-	25650246_gestational_age
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg23053008	chr7:155094291	7	155094291	INSIG1	Open sea	-	-	0.00000000727	-	26857698_primary_sjogrens_syndrome_whole_blood
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg21528729	chr7:155095191	7	155095191	INSIG1	Open sea	0.0376	0.00615	0.0000000096	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07491203	chr7:155089714	7	155089714	INSIG1	Island	0.00612	0.00102	0.00000001	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.0017	0.0003	0.000000012	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24669129	chr7:155089712	7	155089712	INSIG1	Island	0.00435	0.00074	0.000000016	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg04811098	chr7:155088454	7	155088454	INSIG1	North shore	-0.00046757	8.22e-05	0.0000000165	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18100653	chr7:155089030	7	155089030	INSIG1	Island	0.00023	0.000041	0.000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23053008	chr7:155094291	7	155094291	INSIG1	Open sea	0.02625	0.00449	0.000000021	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.196696	0.0351052	0.00000002136671	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17927917	chr7:155089006	7	155089006	INSIG1	Island	0.0018	0.00032	0.000000027	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	-0.000057	0.00001	0.00000003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	0.0554	0.00944	0.000000031	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg18100653	chr7:155089030	7	155089030	INSIG1	Island	1.547041	0.2799	0.0000000327	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.0449769	0.00824822	0.00000005035049	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20419410	chr7:155089803	7	155089803	INSIG1	Island	-0.000047	0.0000088	0.00000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10301953	chr7:155088322	7	155088322	INSIG1	North shore	0.0425135	0.00824911	0.0000002587067	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.00034	None	0.00000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12140867	chr7:155100546	7	155100546	INSIG1	Open sea	-0.00904	0.00171	0.00000034	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27127927	chr7:155088332	7	155088332	INSIG1	North shore	0.162723	0.0326328	0.0000006205331	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10099105	chr7:155093457	7	155093457	INSIG1	South shelf	0.011	0.0022	0.0000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27127927	chr7:155088332	7	155088332	INSIG1	North shore	-0.162942	0.0340951	0.000001775723	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10099105	chr7:155093457	7	155093457	INSIG1	South shelf	0.0015	0.00032	0.000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12140867	chr7:155100546	7	155100546	INSIG1	Open sea	0.0025	None	0.000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18100653	chr7:155089030	7	155089030	INSIG1	Island	-0.00979	0.00201	0.0000023	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	27886173	2020-09-15	Ulcerative colitis	EFO_0000729	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Ulcerative colitis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	163	1	Adults	Both	European	cg21528729	chr7:155095191	7	155095191	INSIG1	Open sea	-0.0439	0.00893	0.0000024	None	27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10099105	chr7:155093457	7	155093457	INSIG1	South shelf	0.038344	0.0082505	0.000003389541	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27127927	chr7:155088332	7	155088332	INSIG1	North shore	0.155102	0.0333851	0.000003410467	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27127927	chr7:155088332	7	155088332	INSIG1	North shore	0.154264	0.0332695	0.000003563291	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Soloman O	-	28556291	2017-01-09	Prenatal phthalate exposure	CHEBI_26092	13 weeks gestation	Table S2	DNA methylation	Prenatal phthalate exposure	Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates	M values	mug/l	Illumina HumanMethylation450	Cord blood	Regression coefficients are per 10-fold increase in phthalate	321	1	0	Both	Admixed	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	0.43621308	0.094676	0.00000408	MEOHP	28556291_prenatal_phthalate_exposure_13_weeks_gestation
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg04811098	chr7:155088454	7	155088454	INSIG1	North shore	-0.00039832	8.61e-05	0.00000422	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.001	None	0.0000045	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23053008	chr7:155094291	7	155094291	INSIG1	Open sea	-0.0093	0.002	0.000005	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27600497	chr7:155091023	7	155091023	INSIG1	South shore	-0.00014	0.000031	0.0000075	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12979992	chr7:155100559	7	155100559	INSIG1	Open sea	0.15632	0.0351727	0.000008870638	None	39706196_Hannah-M.-Smith_bmi_discovery
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function decline	EFO_0004312, EFO_0003892	Discovery. FVC. Lung function decline in this paper is defined as a decrease in FVC between visits.	Table S1	Lung function decline	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg24669129	chr7:155089712	7	155089712	INSIG1	Island	1.781	0.4069	0.000012	None	30343628_Carmona-JJ_lung_function_decline_discovery__fvc__lung_function_decline_in_this_paper_is_defined_as_a_decrease_in_fvc_between_visits_
Gadd DA	Generation Scotland	35945220	31/07/2022	GSS protein levels (SeqId = 15526-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSS protein levels (SeqId = 15526-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione synthetase	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.62	0.142	0.000013	None	Gadd-DA_gss_protein_levels__seqid___15526-33__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12979992	chr7:155100559	7	155100559	INSIG1	Open sea	0.0018	None	0.000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17927917	chr7:155089006	7	155089006	INSIG1	Island	0.00096	None	0.000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.0357777	0.00830975	0.00001676856	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Soloman O	-	28556291	2017-01-09	Prenatal phthalate exposure	CHEBI_26092	Average of measurements at 13 weeks and 26 weeks gestation	Table S2	DNA methylation	Prenatal phthalate exposure	Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates	M values	mug/l	Illumina HumanMethylation450	Cord blood	Regression coefficients are per 10-fold increase in phthalate	336	1	0	Both	Admixed	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	0.54276809	0.126576	0.000018	MEOHP	28556291_prenatal_phthalate_exposure_average_of_measurements_at_13_weeks_and_26_weeks_gestation
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17927917	chr7:155089006	7	155089006	INSIG1	Island	0.0350208	0.00825151	0.00002207466	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.0351953	0.00830879	0.00002290197	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	GSR protein levels (SeqId = 19273-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSR protein levels (SeqId = 19273-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione reductase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.6	0.142	0.000023	None	Gadd-DA_gsr_protein_levels__seqid___19273-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01269469	chr7:155090211	7	155090211	INSIG1	Island	0.034844	0.00825156	0.0000242833	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15735287	chr7:155090783	7	155090783	INSIG1	South shore	0.0346175	0.00825162	0.00002741877	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14076	1	Adults (18-65y)	Both	European	cg10099105	chr7:155093457	7	155093457	INSIG1	South shelf	-0.013	0.00307	0.000032	None	Robert-F-Hillary_Incident_COPD_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	IFIT3 protein levels (SeqId = 13642-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFIT3 protein levels (SeqId = 13642-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon-induced protein with tetratricopeptide repeats 3	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.57	0.141	0.000061	None	Gadd-DA_ifit3_protein_levels__seqid___13642-90__somascan_protein_measurement
Soloman O	-	28556291	2017-01-09	Prenatal phthalate exposure	CHEBI_26092	13 weeks gestation	Table S2	DNA methylation	Prenatal phthalate exposure	Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates	M values	mug/l	Illumina HumanMethylation450	Cord blood	Regression coefficients are per 10-fold increase in phthalate	321	1	0	Both	Admixed	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	0.39520472	0.098711	0.0000624	MEHHP	28556291_prenatal_phthalate_exposure_13_weeks_gestation
Soloman O	-	28556291	2017-01-09	Prenatal phthalate exposure	CHEBI_26092	Average of measurements at 13 weeks and 26 weeks gestation	Table S2	DNA methylation	Prenatal phthalate exposure	Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates	M values	mug/l	Illumina HumanMethylation450	Cord blood	Regression coefficients are per 10-fold increase in phthalate	336	1	0	Both	Admixed	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	0.60193981	0.150693	0.0000648	Sum DEHP	28556291_prenatal_phthalate_exposure_average_of_measurements_at_13_weeks_and_26_weeks_gestation
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	mesotrione	None	discovery	10.5281/zenodo.5156585	DNA methylation	mesotrione	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1059	1	Adults	Males	European	cg21054968	chr7:155089542	7	155089542	INSIG1	Island	-0.00365	0.00092	0.000073	None	34516295_Hoang_mesotrione_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg21054968	chr7:155089542	7	155089542	INSIG1	Island	-0.970262	0.2451	0.0000754	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ARMC5 protein levels (SeqId = 8785-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARMC5 protein levels (SeqId = 8785-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Armadillo repeat-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.56	0.142	0.000079	None	Gadd-DA_armc5_protein_levels__seqid___8785-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GSN protein levels (SeqId = 4775-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSN protein levels (SeqId = 4775-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gelsolin	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.56	0.142	0.000081	None	Gadd-DA_gsn_protein_levels__seqid___4775-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC11A protein levels (SeqId = 4500-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC11A protein levels (SeqId = 4500-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 11 member A	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.56	0.142	0.000081	None	Gadd-DA_clec11a_protein_levels__seqid___4500-50__somascan_protein_measurement
Battram T	GEO	27886173	2020-09-15	Ulcerative colitis	EFO_0000729	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Ulcerative colitis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	163	1	Adults	Both	European	cg21341645	chr7:155091523	7	155091523	INSIG1	South shore	-0.0409	0.01007	0.000081	None	27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Soloman O	-	28556291	2017-01-09	Prenatal phthalate exposure	CHEBI_26092	Average of measurements at 13 weeks and 26 weeks gestation	Table S2	DNA methylation	Prenatal phthalate exposure	Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates	M values	mug/l	Illumina HumanMethylation450	Cord blood	Regression coefficients are per 10-fold increase in phthalate	336	1	0	Both	Admixed	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	0.5242073	0.133279	0.0000838	MEHHP	28556291_prenatal_phthalate_exposure_average_of_measurements_at_13_weeks_and_26_weeks_gestation
Gadd DA	Generation Scotland	35945220	31/07/2022	ITIH3 protein levels (SeqId = 7145-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITIH3 protein levels (SeqId = 7145-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inter-alpha-trypsin inhibitor heavy chain H3	774	1	Adults (18-65 years)	Both	European	cg01708493	chr7:155089390	7	155089390	INSIG1	Island	-0.72	0.182	0.000087	None	Gadd-DA_itih3_protein_levels__seqid___7145-1__somascan_protein_measurement
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg12140867	chr7:155100546	7	155100546	INSIG1	Open sea	1.1	None	0.000087	None	34044884_Inkster-A_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	BCAR3 protein levels (SeqId = 12634-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BCAR3 protein levels (SeqId = 12634-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Breast cancer anti-estrogen resistance protein 3	774	1	Adults (18-65 years)	Both	European	cg08142860	chr7:155089394	7	155089394	INSIG1	Island	-0.56	0.142	0.000089	None	Gadd-DA_bcar3_protein_levels__seqid___12634-79__somascan_protein_measurement
Battram T	GEO	24559495	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Peripheral blood mononuclear cells	None	111	1	Adults	Females	African	cg15735287	chr7:155090783	7	155090783	INSIG1	South shore	0.0075	0.0018	0.000097	None	24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00974308	chr7:155093304	7	155093304	INSIG1	South shelf	0.0321194	0.00825231	0.0000997895	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1