author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01180046 chr5:96271324 5 96271324 LNPEP Island -0.00021 0.000018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01587550 chr5:96271216 5 96271216 LNPEP Island -0.0002 0.000014 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.0029 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10932427 chr5:96271079 5 96271079 LNPEP Island -0.00016 0.000015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10976376 chr5:96293511 5 96293511 LNPEP Open sea -0.0038 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10936564 chr5:96272218 5 96272218 LNPEP South shore 0.00024 None 4.8e-231 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25467855 chr5:96271197 5 96271197 LNPEP Island 0.00033 None 1.1e-150 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.42076 0.00572 4.5e-143 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10976376 chr5:96293511 5 96293511 LNPEP Open sea -0.30877 0.00555 8.9e-121 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19691163 chr5:96304288 5 96304288 LNPEP Open sea 0.21427 0.0058 1.8e-89 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.2648 0.00809 1.1e-80 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.36394 0.01142 7.8e-79 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2821347 (gene symbol: ERAP2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2821347 (gene symbol: ERAP2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg08175413 chr5:96294187 5 96294187 LNPEP Open sea None None 4.2e-76 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2821347__gene_symbol__erap2__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.16666 0.00549 2.3e-75 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.141664 0.0081733 1.231361e-66 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.126001 0.00819077 5.490404e-53 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.125941 0.00819083 6.146819e-53 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.125925 0.00819085 6.342673e-53 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.123576 0.00819329 5.086483e-51 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.113308 0.0082034 3.999755e-43 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10936564 chr5:96272218 5 96272218 LNPEP South shore 0.00068 None 6e-43 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25467855 chr5:96271197 5 96271197 LNPEP Island 0.00095 None 2.3e-34 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10878230 chr5:96314976 5 96314976 LNPEP Open sea 0.03054 0.00204 3.1000000000000002e-34 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0985675 0.00821637 5.2898790000000004e-33 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0979031 0.00821691 1.400293e-32 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24787830 chr5:96364624 5 96364624 LNPEP Open sea 0.06201 0.00438 1.1e-31 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0935674 0.00822035 6.829915e-30 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0933952 0.00822048 8.681924e-30 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0923031 0.00822132 3.9381210000000004e-29 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0910849 0.00822225 2.082434e-28 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0869781 0.00822528 4.855539e-26 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ERAP2 protein levels (SeqId = 8960-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERAP2 protein levels (SeqId = 8960-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endoplasmic reticulum aminopeptidase 2 774 1 Adults (18-65 years) Both European cg21099238 chr5:96299144 5 96299144 LNPEP Open sea -0.99 0.094 6.6e-26 None Gadd-DA_erap2_protein_levels__seqid___8960-3__somascan_protein_measurement Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2821347 (gene symbol: ERAP2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2821347 (gene symbol: ERAP2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11247817 chr5:96294344 5 96294344 LNPEP Open sea None None 3.4999999999999997e-25 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2821347__gene_symbol__erap2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0849881 0.0082267 6.22776e-25 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0841965 0.00822725 1.690463e-24 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0823452 0.00822853 1.684264e-23 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0821524 0.00822866 2.1337580000000003e-23 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0817559 0.00822893 3.463989e-23 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0783461 0.00823119 2.0318409999999998e-21 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0775894 0.00823168 4.899275e-21 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0770391 0.00823203 9.243817e-21 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0768914 0.00823213 1.095245e-20 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0762457 0.00823254 2.290575e-20 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.074777 0.00823346 1.198824e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0739459 0.00823397 3.0158079999999997e-19 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0736714 0.00823413 4.0809069999999995e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0720676 0.0082351 2.336728e-18 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0712309 0.0082356 5.720632e-18 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.070908 0.00823579 8.059539e-18 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0704326 0.00823607 1.3312480000000001e-17 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0701703 0.00823622 1.7534620000000002e-17 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0699695 0.00823634 2.1636030000000002e-17 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0694572 0.00823663 3.688897e-17 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.069369 0.00823668 4.042498e-17 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0692431 0.00823675 4.605395e-17 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea - - 4.86e-17 - 26857698_primary_sjogrens_syndrome_whole_blood Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0687609 0.00823703 7.571935000000001e-17 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0677641 0.00823759 2.093551e-16 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -2.1 0.265 6e-16 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0657111 0.00823873 0.000000000000001624196 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg01587550 chr5:96271216 5 96271216 LNPEP Island 0.01101 0.0014 0.00000000000000228 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.065365 0.00823891 0.000000000000002280375 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea -0.0648777 0.00823918 0.000000000000003665585 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0644863 0.00823939 0.000000000000005353911 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18920488 chr5:96270961 5 96270961 LNPEP Island 0.01096 0.0013 0.000000000000009 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0639295 0.00823968 0.000000000000009142032 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10976376 chr5:96293511 5 96293511 LNPEP Open sea 0.013 0.0016 0.000000000000017 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0631958 0.00824007 0.00000000000001837278 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0631409 0.0082401 0.00000000000001935163 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0630586 0.00824014 0.0000000000000209163 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11191571 chr5:96271967 5 96271967 LNPEP Island -0.000093 0.000012 0.000000000000033 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18920488 chr5:96270961 5 96270961 LNPEP Island -0.000072 0.0000095 0.000000000000038 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0623526 0.00824051 0.00000000000004058783 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.201131 0.02699 0.00000000000009599516 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22566142 chr5:96298493 5 96298493 LNPEP Open sea None None 0.00000000000019 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0788722 0.0107732 0.0000000000002586037 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0786783 0.0107713 0.0000000000002928143 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0596981 0.00824185 0.0000000000004597329 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.307988 0.0426495 0.0000000000005360665 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0592708 0.00824206 0.0000000000006729735 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.22811 0.0322828 0.000000000001655493 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24787830 chr5:96364624 5 96364624 LNPEP Open sea -0.0015 0.00021 0.0000000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0578912 0.00824272 0.000000000002262059 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.193774 0.0277094 0.000000000002787549 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0574922 0.00824291 0.000000000003195332 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -2.7 0.392 0.0000000000035 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.036 0.0046 0.000000000004 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.081843 0.011794 0.000000000004103121 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0018 None 0.000000000006 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.254215 0.0370443 0.000000000006997771 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg19691163 chr5:96304288 5 96304288 LNPEP Open sea -0.23995 0.035 0.00000000000747 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.056273 0.00824349 0.000000000009051396 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0557947 0.00824371 0.00000000001353879 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0795925 0.0118123 0.00000000001664316 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0551935 0.00824399 0.00000000002235118 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0551902 0.00824399 0.00000000002241244 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0551755 0.00824399 0.00000000002268617 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0550255 0.00824406 0.00000000002568797 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.054915 0.00824411 0.00000000002814386 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.195758 0.0295214 0.00000000003431466 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.032 0.00479 0.000000000035 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0766048 0.0117058 0.00000000006181743 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0536244 0.00824469 0.00000000008068534 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0532104 0.00824487 0.0000000001125399 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg07248814 chr5:96270413 5 96270413 LNPEP North shore 0.01178 0.0018 0.000000000127 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0527926 0.00824506 0.000000000157053 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0524392 0.00824521 0.0000000002077933 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.203304 0.0321748 0.0000000002701686 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.144505 0.0229106 0.000000000290704 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0518226 0.00824548 0.0000000003371826 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0518183 0.00824548 0.0000000003383139 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0517401 0.00824551 0.0000000003595934 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0516036 0.00824557 0.0000000003998973 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.249228 0.0399091 0.0000000004336863 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0729846 0.0117142 0.0000000004778024 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0513577 0.00824568 0.0000000004839611 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.0512938 0.0082457 0.0000000005084562 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0509922 0.00824583 0.0000000006415491 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.16947 0.0276092 0.0000000008520935 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.0504908 0.00824604 0.0000000009415186 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0549352 0.0090456 0.000000001285285 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea -0.0500323 0.00824623 0.000000001332845 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0497335 0.00824635 0.000000001668913 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0562297 0.00936264 0.000000001949393 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0492429 0.00824655 0.000000002407596 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.191542 0.0320881 0.000000002430225 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.253042 0.042395 0.0000000024387 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07248814 chr5:96270413 5 96270413 LNPEP North shore 0.00026 None 0.0000000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22566142 chr5:96298493 5 96298493 LNPEP Open sea None None 0.0000000034 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.217168 0.0368188 0.000000003741186 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0532779 0.00903374 0.000000003767996 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0482859 0.00824694 0.000000004871934 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0481598 0.00824699 0.000000005340775 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0553772 0.00950271 0.000000005744006 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.70669793 0.1215 0.00000000608 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0479684 0.00824707 0.000000006137374 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0479471 0.00824708 0.000000006232931 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0551397 0.00954786 0.000000007847404 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0475285 0.00824724 0.000000008431 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.047354 0.00824731 0.000000009555557 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.047287 0.00824734 0.00000001002502 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0544572 0.00950785 0.00000001038577 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0471791 0.00824738 0.00000001082829 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg03574598 chr5:96271227 5 96271227 LNPEP Island 1.44231 0.2523 0.0000000109 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0540958 0.0094985 0.00000001255975 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0667142 0.0117374 0.0000000134166 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.157391 0.0277444 0.00000001426594 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0465205 0.00824763 0.00000001727155 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0464063 0.00824768 0.00000001871694 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0463233 0.00824771 0.00000001983956 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0533097 0.00949161 0.00000001983999 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.046295 0.00824772 0.00000002023695 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0534182 0.00951761 0.00000002029638 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26182335 chr5:96299932 5 96299932 LNPEP Open sea 0.0462016 0.00824775 0.00000002160444 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0658026 0.0117496 0.00000002176864 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0461084 0.00824779 0.00000002305942 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0460859 0.0082478 0.00000002342446 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0656041 0.0117475 0.00000002384795 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.045932 0.00824786 0.00000002607563 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22755475 chr5:96271822 5 96271822 LNPEP Island 0.00015 0.000027 0.000000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09593402 chr5:96270297 5 96270297 LNPEP North shore 0.00747 0.00129 0.000000028 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10878230 chr5:96314976 5 96314976 LNPEP Open sea -0.00079 0.00014 0.000000028 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0457866 0.00824791 0.00000002884826 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0708103 0.0127942 0.0000000317381 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0526776 0.00953674 0.00000003376825 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0515333 0.00933892 0.00000003484572 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0511952 0.00928666 0.00000003592095 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0454664 0.00824803 0.00000003599734 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03574598 chr5:96271227 5 96271227 LNPEP Island 0.00027 None 0.000000036 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0454095 0.00824805 0.00000003743423 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0514167 0.00934858 0.00000003862667 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.201391 0.0366888 0.00000004093264 None 39706196_Hannah-M.-Smith_glucose_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.23317 0.0425217 0.00000004226921 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0451717 0.00824814 0.00000004407227 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0450354 0.00824819 0.00000004837859 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -1.4 0.248 0.000000049 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.151562 0.0278099 0.00000005107629 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0448855 0.00824825 0.00000005358652 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.200731 0.0369284 0.00000005533121 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0447853 0.00824829 0.00000005736451 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07528772 chr5:96271255 5 96271255 LNPEP Island 0.00019 None 0.000000059 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.044687 0.00824832 0.00000006132017 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.160109 0.0295569 0.00000006141927 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0514556 0.0094993 0.00000006164202 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.00103904 0.00019089 0.0000000649 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.068 0.0126 0.000000072 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0443772 0.00824844 0.00000007559842 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.123079 0.0229357 0.00000008141715 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0442364 0.00824849 0.00000008310547 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04518888 chr5:96271449 5 96271449 LNPEP Island 0.00019 0.000036 0.000000084 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0500519 0.00935731 0.00000008978565 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0629915 0.0118198 0.0000001000379 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0492849 0.0092716 0.0000001078138 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0503951 0.00948692 0.0000001099775 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.043549 0.00824874 0.0000001314023 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0477471 0.00912428 0.0000001691045 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0601125 0.0115217 0.0000001840089 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.048689 0.00934003 0.0000001883985 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg18920488 chr5:96270961 5 96270961 LNPEP Island 1.214426 0.2331 0.00000019 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0614462 0.0117927 0.0000001908618 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0429675 0.00824895 0.0000001925859 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0480709 0.00923627 0.000000197069 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0428933 0.00824897 0.0000002021444 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.208542 0.0402682 0.0000002257769 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0608298 0.0117826 0.0000002466037 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10976376 chr5:96293511 5 96293511 LNPEP Open sea 0.0017 None 0.00000025 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0481349 0.0093335 0.0000002539081 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.00127458 0.00024569 0.000000255 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0424246 0.00824914 0.0000002739949 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0499384 0.00972108 0.0000002825538 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0487679 0.00950066 0.0000002886334 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0470693 0.00919795 0.0000003137339 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0421118 0.00824925 0.0000003350633 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0419868 0.00824929 0.0000003629842 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0419763 0.00824929 0.0000003654313 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.041974 0.0082493 0.000000365958 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0600393 0.0118 0.0000003662076 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0480034 0.00948219 0.0000004188535 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0417523 0.00824937 0.0000004214993 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25467855 chr5:96271197 5 96271197 LNPEP Island -0.00011 0.000021 0.00000045 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.02 0.00398 0.00000047 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0415366 0.00824945 0.0000004833231 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0467648 0.00929985 0.0000005000367 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0414605 0.00824947 0.000000507152 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.046134 0.00920904 0.0000005516527 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0588849 0.0117914 0.0000005985297 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0411879 0.00824957 0.0000006021225 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0087 0.0017 0.00000066 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0410016 0.00824963 0.000000676676 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0472447 0.0095146 0.0000006929645 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0409546 0.00824964 0.0000006968311 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0408657 0.00824967 0.0000007365745 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0408218 0.00824969 0.0000007569904 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07248814 chr5:96270413 5 96270413 LNPEP North shore -0.00018 0.000036 0.00000077 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26182335 chr5:96299932 5 96299932 LNPEP Open sea -0.0708839 0.0143525 0.0000007930574 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0468029 0.0094821 0.0000008065073 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0407102 0.00824973 0.0000008114335 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0013 0.00026 0.00000086 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0457172 0.00929107 0.0000008723739 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0405355 0.00824979 0.0000009041935 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0405249 0.00824979 0.0000009101468 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea -0.040449 0.00824981 0.0000009538628 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0404463 0.00824982 0.0000009554512 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14202472 chr5:96296075 5 96296075 LNPEP Open sea 0.04237 0.00866363 0.000001016179 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0471846 0.00966019 0.000001048201 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0478855 0.0098052 0.0000010522 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0402485 0.00824988 0.000001079239 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0402217 0.00824989 0.0000010971 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.948749 0.1947 0.0000011 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0444507 0.00912134 0.000001109158 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.178565 0.0366896 0.000001143039 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg16189644 chr5:96271684 5 96271684 LNPEP Island -0.215706 0.0444 0.00000119 - 27105112_hiv_infection_neutrophils Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.205981 0.0424161 0.000001206703 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.057281 0.0118119 0.000001250809 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0399933 0.00824997 0.000001261868 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0571684 0.0118114 0.000001310885 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0398675 0.00825001 0.000001362451 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0570008 0.0118391 0.000001489536 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0397025 0.00825006 0.000001506222 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.110447 0.022992 0.000001570517 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0565117 0.0117701 0.000001591875 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0577411 0.0120264 0.000001592818 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.034 0.00699 0.0000016 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0448951 0.00936062 0.000001633223 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14202472 chr5:96296075 5 96296075 LNPEP Open sea -0.107127 0.0223389 0.000001635369 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P69905 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P69905 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0395493 0.00825011 0.000001652617 P69905 41361833_Josephine_Robertson_P69905_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07528772 chr5:96271255 5 96271255 LNPEP Island 0.00062 None 0.0000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0563451 0.0118007 0.000001817035 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0443083 0.00928455 0.000001839263 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0393372 0.00825018 0.000001878156 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03635536 chr5:96271340 5 96271340 LNPEP Island 0.0392824 0.0082502 0.000001941014 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0443246 0.00931709 0.000001980228 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0392254 0.00825022 0.000002008637 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0452624 0.00952003 0.000002008906 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14202472 chr5:96296075 5 96296075 LNPEP Open sea 0.109067 0.0229433 0.000002012648 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0389751 0.0082503 0.000002333007 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg16030703 chr5:96271524 5 96271524 LNPEP Island 0.159912 0.0338719 0.000002363311 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea -0.0389278 0.00825031 0.000002399629 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0388691 0.00825033 0.000002484955 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0388668 0.00825033 0.000002488486 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.038815 0.00825035 0.000002566284 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0446438 0.00950588 0.000002671412 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0387471 0.00825037 0.000002671801 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0387371 0.00825037 0.000002687741 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.143582 0.0306035 0.00000272937 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0386327 0.00825041 0.000002859067 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0553058 0.0118183 0.000002898962 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0385413 0.00825044 0.000003017768 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.038442 0.00825047 0.000003199565 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0383055 0.00825051 0.000003466913 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0382569 0.00825053 0.000003567131 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.038219 0.00825054 0.000003647289 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0382137 0.00825054 0.000003658629 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0380959 0.00825058 0.000003919415 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0380911 0.00825058 0.000003930578 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0437981 0.009495 0.000004007266 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0379716 0.00825062 0.000004214088 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0423727 0.00921489 0.000004295413 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0379257 0.00825063 0.000004328007 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11247817 chr5:96294344 5 96294344 LNPEP Open sea None None 0.0000044 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0378821 0.00825065 0.000004439252 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16189644 chr5:96271684 5 96271684 LNPEP Island 0.0024 0.00051 0.0000045 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0378471 0.00825066 0.0000045303 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03574598 chr5:96271227 5 96271227 LNPEP Island 0.00085 None 0.0000046 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0421615 0.00919939 0.000004619702 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0538329 0.0117729 0.000004855809 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.037683 0.00825071 0.000004981881 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0561086 0.0122869 0.000004998814 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea -0.0376252 0.00825073 0.000005150999 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.01 0.0023 0.0000055 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0375109 0.00825076 0.000005501799 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0375065 0.00825076 0.000005515991 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.04297 0.00946557 0.000005680574 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0440912 0.00972558 0.000005846536 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea -0.0373653 0.00825081 0.000005982033 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0373644 0.00825081 0.000005985015 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0373273 0.00825082 0.000006113582 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.181494 0.0401292 0.000006145183 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.129825 0.0287311 0.000006263926 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.061 0.0135 0.0000063 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0372489 0.00825084 0.000006394432 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0372053 0.00825085 0.000006555517 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0371807 0.00825086 0.000006648305 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22755475 chr5:96271822 5 96271822 LNPEP Island 0.00016 None 0.0000073 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Chronic Kidney Disease None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Chronic Kidney Disease Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18000 1 Adults (18-65y) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.014 0.00302 0.0000074 None Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0369925 0.00825092 0.000007400551 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0435136 0.0097107 0.000007485714 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0434077 0.00972091 0.000008051864 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg09593402 chr5:96270297 5 96270297 LNPEP North shore 0.140111 0.03138 0.000008056262 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0368109 0.00825098 0.000008203163 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0366724 0.00825102 0.000008870448 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0366685 0.00825102 0.000008890104 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0366404 0.00825103 0.000009031892 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0366361 0.00825103 0.000009053698 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.040784 0.00918745 0.000009099622 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0366059 0.00825104 0.000009208838 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0522849 0.0118058 0.000009546695 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0365025 0.00825107 0.000009759789 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.176488 0.0400173 0.00001038517 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0408219 0.00926771 0.00001066566 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0427551 0.00971073 0.00001075852 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0363249 0.00825112 0.00001078101 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0411293 0.00935675 0.00001112029 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0538153 0.0122558 0.00001136131 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0362063 0.00825116 0.00001151809 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0417091 0.0095154 0.00001176928 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0361042 0.00825119 0.00001219153 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01009 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01009 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0360051 0.00825122 0.00001288098 P01009 41361833_Josephine_Robertson_P01009_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0360045 0.00825122 0.00001288469 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LUM protein levels (SeqId = 13114-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LUM protein levels (SeqId = 13114-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lumican 774 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.84 0.192 0.000013 None Gadd-DA_lum_protein_levels__seqid___13114-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0359804 0.00825123 0.00001305846 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14202472 chr5:96296075 5 96296075 LNPEP Open sea -0.035934 0.00825124 0.00001339812 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0404877 0.00932755 0.00001430102 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0358151 0.00825127 0.00001430789 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0513119 0.0118311 0.00001453803 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 IGLL1 protein levels (SeqId = 6485-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGLL1 protein levels (SeqId = 6485-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Immunoglobulin lambda-like polypeptide 1 774 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.56 0.129 0.000015 None Gadd-DA_igll1_protein_levels__seqid___6485-59__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0357152 0.0082513 0.00001511743 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0398726 0.00922661 0.0000156003 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.035654 0.00825132 0.00001563429 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0514966 0.0119314 0.00001598856 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0355182 0.00825136 0.00001684254 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0355151 0.00825136 0.0000168711 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17284325 chr5:96270930 5 96270930 LNPEP Island -0.000033 0.0000076 0.000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0354805 0.00825137 0.00001719416 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0354047 0.0082514 0.00001792062 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.036 0.00842 0.000018 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0353703 0.00825141 0.00001826079 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0353111 0.00825142 0.00001885885 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0407227 0.00952615 0.00001924881 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0352252 0.00825145 0.00001976093 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.039452 0.0092679 0.0000208621 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0350856 0.00825149 0.00002131461 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0403899 0.00950016 0.00002136649 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0398594 0.00938257 0.00002167899 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0350486 0.0082515 0.00002174557 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0350455 0.0082515 0.00002178276 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0377117 0.00887958 0.00002179743 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0349962 0.00825151 0.00002237054 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0349737 0.00825152 0.00002264437 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22566142 chr5:96298493 5 96298493 LNPEP Open sea None None 0.000023 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22755475 chr5:96271822 5 96271822 LNPEP Island 0.0348445 0.00825156 0.00002427601 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.039329 0.0093152 0.00002435755 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0347936 0.00825157 0.00002494943 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TNFRSF17 protein levels (SeqId = 2665-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFRSF17 protein levels (SeqId = 2665-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor receptor superfamily member 17 774 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.6 0.143 0.000025 None Gadd-DA_tnfrsf17_protein_levels__seqid___2665-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0347873 0.00825157 0.00002503403 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.039298 0.00935823 0.00002693225 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0380683 0.00906737 0.00002704131 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0458013 0.0109187 0.00002747567 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.034595 0.00825163 0.00002775089 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0344741 0.00825166 0.00002960011 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0526488 0.0126088 0.00002989616 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0491996 0.0117862 0.0000300598 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26182335 chr5:96299932 5 96299932 LNPEP Open sea 0.0343989 0.00825169 0.00003080809 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea -0.0343938 0.00825169 0.0000308918 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.0382104 0.00920713 0.00003342193 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03574598 chr5:96271227 5 96271227 LNPEP Island 0.0342312 0.00825173 0.000033674 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0342242 0.00825173 0.00003379955 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Fragoso-Bargas Nicolas EPIPREG (Epigenetics in pregnancy) 39844050 Jan 22, 2025 Moderate physical activity EFO:0000001 discovery (step adjusted) None DNA methylation Moderate physical activity Age,Smoking,Cell composition (reference based) M values hours/day Illumina HumanMethylationEPIC Whole blood analysis of pregnant women (gestational week 28) 353 1 Adults (18-65 years) Females European,South Asian cg18920488 chr5:96270961 5 96270961 LNPEP Island -0.090919994 0.021667856 0.0000347 None 39844050_Fragoso-Bargas-Nicolas_moderate_physical_activity_discovery_(step_adjusted) Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea -0.0341557 0.00825175 0.00003504617 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0341534 0.00825175 0.00003508799 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0341523 0.00825175 0.0000351092 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0487887 0.0118107 0.0000363355 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0340832 0.00825177 0.0000364129 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea 0.0340096 0.0082518 0.00003785083 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07248814 chr5:96270413 5 96270413 LNPEP North shore 0.00076 None 0.000038 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0485862 0.0117916 0.00003802686 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0066 0.0016 0.000039 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21099238 chr5:96299144 5 96299144 LNPEP Open sea -0.0339522 0.00825181 0.00003901192 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0339157 0.00825182 0.00003976695 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MAN1C1 protein levels (SeqId = 13427-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAN1C1 protein levels (SeqId = 13427-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC 774 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.53 0.129 0.00004 None Gadd-DA_man1c1_protein_levels__seqid___13427-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0381469 0.0092866 0.00004017184 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0484074 0.011788 0.00004039143 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 NAALAD2 protein levels (SeqId = 7986-98) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NAALAD2 protein levels (SeqId = 7986-98) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: N-acetylated-alpha-linked acidic dipeptidase 2 774 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.79 0.192 0.000041 None Gadd-DA_naalad2_protein_levels__seqid___7986-98__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.100638 0.0245291 0.00004100158 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0338204 0.00825185 0.00004180247 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea 0.0338042 0.00825185 0.00004215858 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0337671 0.00825186 0.00004298391 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0377909 0.00924514 0.00004380822 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.033615 0.00825191 0.000046535 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P13671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P13671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0335999 0.00825191 0.00004690061 P13671 41361833_Josephine_Robertson_P13671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0335743 0.00825192 0.00004752933 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.0335579 0.00825192 0.00004793833 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10878230 chr5:96314976 5 96314976 LNPEP Open sea 0.0025 None 0.000048 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0335539 0.00825192 0.00004803626 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0380631 0.00936615 0.00004851145 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0085 0.0021 0.000049 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14630392 chr5:96292764 5 96292764 LNPEP Open sea 0.033501 0.00825194 0.00004937529 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0476116 0.0117394 0.00005024481 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea -0.0334444 0.00825195 0.00005084489 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0375405 0.00928891 0.00005339654 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.033348 0.00825198 0.00005344607 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0332716 0.008252 0.00005559577 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea -0.0332307 0.00825201 0.00005678124 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P69905 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P69905 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea 0.0476072 0.0118399 0.00005826828 P69905 41361833_Josephine_Robertson_P69905_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0331627 0.00825203 0.00005880295 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf 0.0331071 0.00825205 0.00006050829 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03603918 chr5:96293389 5 96293389 LNPEP Open sea 0.0331046 0.00825205 0.00006058775 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0474027 0.0118169 0.00006064858 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.0330953 0.00825205 0.00006087513 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 QPCT protein levels (SeqId = 7849-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QPCT protein levels (SeqId = 7849-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaminyl-peptide cyclotransferase 774 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea -0.38 0.095 0.000061 None Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14202472 chr5:96296075 5 96296075 LNPEP Open sea 0.0347042 0.00865476 0.00006106102 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0473973 0.0118204 0.00006107232 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24787830 chr5:96364624 5 96364624 LNPEP Open sea 0.008 0.002 0.000062 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea 0.0330545 0.00825206 0.00006216378 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22755475 chr5:96271822 5 96271822 LNPEP Island 0.00053 None 0.000063 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0470441 0.0117547 0.00006307484 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0329815 0.00825208 0.00006453228 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea -0.0434415 0.0108911 0.00006675222 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 CECR1 protein levels (SeqId = 6077-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CECR1 protein levels (SeqId = 6077-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenosine deaminase 2 774 1 Adults (18-65 years) Both European cg04518888 chr5:96271449 5 96271449 LNPEP Island -0.72 0.18 0.000068 None Gadd-DA_cecr1_protein_levels__seqid___6077-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.68 0.171 0.000069 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea 0.0328462 0.00825212 0.00006915001 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0328297 0.00825212 0.00006973475 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg22566142 chr5:96298493 5 96298493 LNPEP Open sea 0.02 0.00493 0.00007 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03635536 chr5:96271340 5 96271340 LNPEP Island -0.0328063 0.00825213 0.00007056874 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Jiahui Si China Kadoorie Biobank 34515027 Sep 13, 2021 coronary heart disease None discovery dropbox coronary heart disease DNA methylation Age, Sex, Smoking, Cell composition (reference free), Batch effects, Body mass index, Education, fasting time, marital status, smoking, alcohol consumption, physical activity, diet score. None Beta values Illumina HumanMethylationEPIC Whole blood None 982 1 Adults Both East Asian cg14202472 chr5:96296075 5 96296075 LNPEP Open sea -0.0117 0.00294 0.000071 None 34515027_Jiahui-Si_coronary_heart_disease_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0327877 0.00825213 0.00007124244 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26182335 chr5:96299932 5 96299932 LNPEP Open sea 0.0327631 0.00825214 0.00007213871 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea 0.0327574 0.00825214 0.00007234894 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10178827 chr5:96275355 5 96275355 LNPEP South shelf -0.0327352 0.00825215 0.00007317018 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0327155 0.00825215 0.00007390386 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0327149 0.00825215 0.00007392701 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0326287 0.00825218 0.00007723308 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.124103 0.031412 0.00007818944 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22196750 chr5:96309629 5 96309629 LNPEP Open sea 0.0325725 0.00825219 0.00007946033 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.0325718 0.00825219 0.00007949097 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg25467855 chr5:96271197 5 96271197 LNPEP Island -0.310104 0.0787 0.0000819 - 27105112_hiv_infection_neutrophils Gadd DA Generation Scotland 35945220 31/07/2022 TOR4A protein levels (SeqId = 13459-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TOR4A protein levels (SeqId = 13459-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Torsin-4A 774 1 Adults (18-65 years) Both European cg04104119 chr5:96345459 5 96345459 LNPEP Open sea -0.377 0.096 0.000083 None Gadd-DA_tor4a_protein_levels__seqid___13459-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15589135 chr5:96294128 5 96294128 LNPEP Open sea -0.0367201 0.00936507 0.00008859808 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.0364159 0.00930256 0.00009096015 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg04518888 chr5:96271449 5 96271449 LNPEP Island -0.121724 0.0312 0.0000937 - 27105112_hiv_infection_neutrophils Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0453029 0.0116095 0.00009573798 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08175413 chr5:96294187 5 96294187 LNPEP Open sea -0.0321892 0.00825229 0.00009636942 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.75 0.192 0.000097 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.032163 0.0082523 0.00009763935 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11247817 chr5:96294344 5 96294344 LNPEP Open sea -0.0321618 0.0082523 0.00009769597 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FTL protein levels (SeqId = 15324-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTL protein levels (SeqId = 15324-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin light chain 774 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea -0.75 0.192 0.000099 None Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg24611214 chr5:96298662 5 96298662 LNPEP Open sea -0.67 0.171 0.000099 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04499272 chr5:96298625 5 96298625 LNPEP Open sea -0.0321342 0.00825231 0.00009905364 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21465673 chr5:96298581 5 96298581 LNPEP Open sea 0.035544 0.00913165 0.00009969785 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_3