author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0029	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.013	0.0015	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13053082	chr3:182813224	3	182813224	MCCC1	North shelf	0.39777	0.00556	7.1e-141	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.31108	0.0051	4.3e-128	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11341215	chr3:182786070	3	182786070	MCCC1	South shelf	0.45249	0.00785	1.5000000000000001e-123	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.146932	0.00816696	1.34451e-71	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.114285	0.00820247	7.593924e-44	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.104764	0.00821114	4.383153e-37	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.10438	0.00821147	7.980032e-37	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.104284	0.00821155	9.273979e-37	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	-0.0381	0.00251	7.8e-35	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0904822	0.0082227	4.708893e-28	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0904454	0.00822273	4.948653e-28	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	0.05702	0.0047	1.4e-25	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0840949	0.00822732	1.920303e-24	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg13053082	chr3:182813224	3	182813224	MCCC1	North shelf	-	-	2.0299999999999998e-24	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23476885	chr3:182782313	3	182782313	MCCC1	Island	0.00095	None	2.2e-23	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16818145	chr3:182782277	3	182782277	MCCC1	Island	0.03647	0.00322	4.3e-23	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	None	None	1.7000000000000002e-22	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0796511	0.00823034	4.364606e-22	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	-0.05	0.00423	8.4e-21	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0759487	0.00823272	3.209382e-20	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0738288	0.00823404	3.431828e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0738142	0.00823405	3.4872089999999995e-19	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0732705	0.00823438	6.335134e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0731688	0.00823444	7.080033999999999e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.07295	0.00823457	8.988382e-19	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0922011	0.0105354	2.331399e-18	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	None	None	2.8e-18	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04909259	chr3:182782565	3	182782565	MCCC1	Island	0.02506	0.00264	8e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	None	None	1.4e-17	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg25441771	chr3:182816738	3	182816738	MCCC1	North shore	None	None	4.3e-17	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0671851	0.00823792	3.7542e-16	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0665378	0.00823827	7.170901e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	-0.025	0.00261	7.5e-16	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0639982	0.00823965	0.000000000000008559967	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0633137	0.00824001	0.00000000000001643175	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.079813	0.0105434	0.00000000000003956165	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	None	None	0.00000000000097	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	0.012	0.0017	0.000000000001	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.057884	0.00824273	0.000000000002276311	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg23103447	chr3:182813504	3	182813504	MCCC1	North shelf	-0.012	0.00151	0.0000000000025	None	32795589_Kyung-WK_atopy_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	None	None	0.0000000000026	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0575821	0.00824287	0.000000000002956743	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05496383	chr3:182817381	3	182817381	MCCC1	Island	0.0083	0.0012	0.0000000000035	None	33450751_Mulder-RH_sex_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg07464924	chr3:182817250	3	182817250	MCCC1	Island	None	None	0.000000000005	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	None	None	0.0000000000079	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0558833	0.00824367	0.00000000001256846	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	None	None	0.000000000014	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	-0.00083	0.00012	0.000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13053082	chr3:182813224	3	182813224	MCCC1	North shelf	-0.0012	0.00018	0.000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	0.011	0.0016	0.000000000017	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07464924	chr3:182817250	3	182817250	MCCC1	Island	-0.00049	0.000073	0.000000000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0548214	0.00824416	0.00000000003040127	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0538828	0.00824458	0.00000000006547028	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Knijnenburg	None	30833390	Mar 19, 2019	very early preterm birth (<28 weeks)	EFO_0003917	discovery	Supplementary dataset 10	DNA methylation	very early preterm birth (<28 weeks)	Age, Ancestry (genomic PCs), time since birth	M values	None	Illumina HumanMethylation450	whole blood	None	784	1	Adults	Females	Admixed	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.43	0.065	0.00000000009	None	30833390_Knijnenburg_very_early_preterm_birth___28_weeks__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.053372	0.0082448	0.00000000009885972	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.053021	0.00824496	0.0000000001309346	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	-0.00084	0.00013	0.00000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0523018	0.00824527	0.0000000002315746	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg13053082	chr3:182813224	3	182813224	MCCC1	North shelf	-0.02143	0.0034	0.000000000239	-	23334450_rheumatoid_arthritis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	0.02966	0.00448	0.00000000036	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.051729	0.00824552	0.000000000362716	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0513454	0.00824568	0.000000000488573	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	-0.0510686	0.0082458	0.0000000006049255	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg05496383	chr3:182817381	3	182817381	MCCC1	Island	None	None	0.00000000096	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	0.0072	0.0012	0.000000001	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.013	0.0022	0.0000000011	None	33450751_Mulder-RH_sex_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg04909259	chr3:182782565	3	182782565	MCCC1	Island	None	None	0.0000000021	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0491339	0.0082466	0.000000002610696	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Knijnenburg	None	30833390	Mar 19, 2019	early preterm birth (<28 weeks)	EFO_0003917	discovery	Supplementary dataset 10	DNA methylation	early preterm birth (<28 weeks)	Age, Ancestry (genomic PCs), time since birth	M values	None	Illumina HumanMethylation450	whole blood	None	784	1	Adults	Females	Admixed	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.24	0.039	0.0000000035	None	30833390_Knijnenburg_early_preterm_birth___28_weeks__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0487363	0.00824676	0.000000003502249	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2707824 (gene symbol: MCCC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg08395365	chr3:182817479	3	182817479	MCCC1	South shore	None	None	0.0000000037	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2707824__gene_symbol__mccc1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0618942	0.0105315	0.000000004266543	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0484368	0.00824688	0.000000004363104	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg11341215	chr3:182786070	3	182786070	MCCC1	South shelf	-1.767179	0.3012	0.00000000445	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	0.0071	0.0012	0.0000000074	None	33450751_Mulder-RH_sex_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05463257	chr3:182782445	3	182782445	MCCC1	Island	-0.01995	0.00331	0.0000000079	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0475377	0.00824724	0.000000008375943	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	0.00029	0.000052	0.000000013	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11341215	chr3:182786070	3	182786070	MCCC1	South shelf	-0.0013	0.00024	0.000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0462184	0.00824775	0.00000002135245	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	0.0049	0.00088	0.000000023	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13053082	chr3:182813224	3	182813224	MCCC1	North shelf	0.0013	None	0.000000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0458036	0.00824791	0.00000002850882	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-2.3	0.419	0.000000036	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0451023	0.00824817	0.00000004621766	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	0.02409	0.0044	0.000000049	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0447706	0.00824829	0.00000005793919	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0445139	0.00824839	0.0000000689398	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg04909259	chr3:182782565	3	182782565	MCCC1	Island	0.10567	0.0198	0.0000000879	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0438186	0.00824864	0.0000001098817	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05463257	chr3:182782445	3	182782445	MCCC1	Island	0.00087	None	0.00000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24852949	chr3:182779854	3	182779854	MCCC1	North shelf	-0.00047	0.00009	0.00000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0431419	0.00824888	0.0000001718185	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0538008	0.0103105	0.0000001832926	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	-0.0448022	0.00860422	0.0000001945122	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	0.00039	0.000074	0.00000022	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23665837	chr3:182783243	3	182783243	MCCC1	South shore	0.0037	0.00073	0.00000029	None	33450751_Mulder-RH_sex_discovery
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	0.0004	0.000078	0.00000037	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	0.00027	0.000054	0.00000037	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0419064	0.00824932	0.0000003821141	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0532984	0.010492	0.0000003822748	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0531242	0.0105251	0.0000004533157	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11341215	chr3:182786070	3	182786070	MCCC1	South shelf	0.0015	None	0.00000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	-0.0411647	0.00824957	0.0000006109685	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	0.0047	0.00094	0.00000062	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23665837	chr3:182783243	3	182783243	MCCC1	South shore	-0.0026	0.00053	0.00000071	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	-0.0422208	0.00851816	0.0000007255124	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.101904	0.0207771	0.0000009460241	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24852949	chr3:182779854	3	182779854	MCCC1	North shelf	0.0043	0.00088	0.000001	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0506634	0.0103718	0.000001046574	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0505626	0.0103589	0.000001066234	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	0.333359	0.068331	0.000001078026	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04909259	chr3:182782565	3	182782565	MCCC1	Island	-0.00035	0.000073	0.0000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.039	0.00804	0.0000012	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0508576	0.0105137	0.000001329863	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	-0.236396	0.0492257	0.000001581156	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25441771	chr3:182816738	3	182816738	MCCC1	North shore	0.0053	0.0011	0.0000017	None	33450751_Mulder-RH_sex_discovery
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg05496383	chr3:182817381	3	182817381	MCCC1	Island	0.00031	0.000065	0.0000018	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07464924	chr3:182817250	3	182817250	MCCC1	Island	0.0041	0.00086	0.0000018	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0393483	0.00825018	0.000001865604	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Anna Ulrich	None	38184627	Dec 5, 2023	Idiopathic/heritable pulmonary arterial hypertension	None	Discovery	None	DNA methylation	Idiopathic/heritable pulmonary arterial hypertension	Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1655	4	Adults	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	24	5	0.0000022	None	38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	-0.001	0.00021	0.00000233	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0389197	0.00825032	0.000002411321	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-0.00056	0.00012	0.0000025	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16818145	chr3:182782277	3	182782277	MCCC1	Island	0.0012	None	0.0000025	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0947036	0.0201306	0.000002568702	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	0.0065	0.0014	0.0000027	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	-0.0386875	0.00825039	0.000002767792	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25441771	chr3:182816738	3	182816738	MCCC1	North shore	-0.00047	0.0001	0.0000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0385204	0.00825044	0.0000030552	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	-	-	0.00000317	-	26500701_sex_kora_f3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02570195	chr3:182818516	3	182818516	MCCC1	South shore	-0.169633	0.0365297	0.000003446345	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	-	-	0.00000349	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0381265	0.00825057	0.000003850041	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11341215	chr3:182786070	3	182786070	MCCC1	South shelf	0.01	0.0022	0.0000039	None	33450751_Mulder-RH_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.215434	0.046721	0.000004034418	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0473736	0.0102898	0.000004180354	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.0391554	0.00851191	0.000004258834	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	-0.002	0.001	0.00000496	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	-	-	0.00000543	-	26500701_sex_kora_f3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.045	0.00996	0.0000057	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	-	-	0.00000697	-	26500701_sex_kora_f3
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg05496383	chr3:182817381	3	182817381	MCCC1	Island	0.0003	0.000068	0.0000073	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	-0.002	0.00045	0.00000738	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	-0.0016	0.0004	0.0000074	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09082773	chr3:182740609	3	182740609	MCCC1	Open sea	0.036975	0.00825093	0.000007474583	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	-0.0021	0.0005	0.0000078	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	-0.002	0.001	0.00000782	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08395365	chr3:182817479	3	182817479	MCCC1	South shore	0.005	0.0011	0.0000081	None	33450751_Mulder-RH_sex_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	-	-	0.00000822	-	26500701_sex_kora_f3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05463257	chr3:182782445	3	182782445	MCCC1	Island	-0.00055	0.00012	0.0000089	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	-	-	0.00000933	-	26500701_sex_kora_f3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02310424	chr3:182733624	3	182733624	MCCC1	Open sea	0.147645	0.0333179	0.000009419414	None	39706196_Hannah-M.-Smith_bmi_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-	-	0.00000981	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0364493	0.00825109	0.00001005574	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0362685	0.00825114	0.00001112582	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	0.00035	0.000079	0.000012	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0360426	0.00825121	0.00001261589	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0460175	0.0105473	0.00001291938	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	0.00033	0.000076	0.000013	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.196131	0.0449711	0.00001300216	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.035967	0.00825123	0.00001315572	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg05496383	chr3:182817381	3	182817381	MCCC1	Island	-	-	0.0000136	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.0358743	0.00825126	0.00001384729	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	-0.0764509	0.0176461	0.00001482915	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0357068	0.00825131	0.00001518714	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0356214	0.00825133	0.00001591671	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	-0.0374275	0.00869047	0.00001667612	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.0362397	0.00844204	0.00001775927	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0650714	0.0151636	0.00001787715	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	-	-	0.0000184	-	26500701_sex_kora_f3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	-0.002	0.00047	0.0000185	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	1.3	0.311	0.000022	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04909259	chr3:182782565	3	182782565	MCCC1	Island	-0.0034	0.00081	0.000023	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0348245	0.00825156	0.00002453919	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.165593	0.0394433	0.0000270244	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	-0.002	0.00048	0.0000271	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08395365	chr3:182817479	3	182817479	MCCC1	South shore	-0.0832469	0.0198731	0.00002816773	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0345213	0.00825165	0.00002886396	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0870628	0.0208562	0.00003004614	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total cholesterol in medium VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	-1.95	0.47	0.000031	None	Battram-T_total_cholesterol_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0343565	0.0082517	0.00003151073	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.034303	0.00825171	0.00003241815	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Jenny van Dongen	BIOS consortium, GoDMC	34584077	Sep 28, 2021	monozygotic twinning	None	None	supplemental table 3	DNA methylation	monozygotic twinning	Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index	Beta values	None	Illumina HumanMethylation450	whole blood	we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method	5723	5	Adults (18-65 years)	Both	European	cg22211233	chr3:182817584	3	182817584	MCCC1	South shore	None	None	0.000034	None	34584077_Jenny-van-Dongen_monozygotic_twinning
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	0.0437136	0.0105436	0.00003402506	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.062829	0.0151668	0.0000345425	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-0.002	0.001	0.0000351	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07634101	chr3:182816873	3	182816873	MCCC1	Island	-0.0731117	0.0176874	0.00003588812	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SELPLG protein levels (SeqId = 11266-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELPLG protein levels (SeqId = 11266-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: P-selectin glycoprotein ligand 1	774	1	Adults (18-65 years)	Both	European	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	-0.24	0.058	0.000036	None	Gadd-DA_selplg_protein_levels__seqid___11266-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.0339868	0.0082518	0.00003830819	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23476885	chr3:182782313	3	182782313	MCCC1	Island	-0.0038	0.00093	0.000039	None	33450751_Mulder-RH_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SELPLG protein levels (SeqId = 11266-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELPLG protein levels (SeqId = 11266-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: P-selectin glycoprotein ligand 1	774	1	Adults (18-65 years)	Both	European	cg22801868	chr3:182817454	3	182817454	MCCC1	Island	-0.17	0.042	0.000042	None	Gadd-DA_selplg_protein_levels__seqid___11266-8__somascan_protein_measurement
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg25441771	chr3:182816738	3	182816738	MCCC1	North shore	-0.19617786	0.04796	0.000043	-	26798409_hypertriglyceridemic_waist
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg25441771	chr3:182816738	3	182816738	MCCC1	North shore	-	-	0.0000446	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0336757	0.00825189	0.00004508659	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.033671	0.00825189	0.00004519553	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0617926	0.0151507	0.00004556182	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16818145	chr3:182782277	3	182782277	MCCC1	Island	0.0038	None	0.000047	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg07464924	chr3:182817250	3	182817250	MCCC1	Island	-	-	0.0000489	-	26500701_sex_kora_f3
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in IDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	672	1	Adults	Females	European	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	0.181	0.044	0.000051	None	Battram-T_phospholipids_to_total_lipids_ratio_in_idl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0612313	0.0151716	0.00005466577	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0332843	0.008252	0.00005523527	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	-0.0332811	0.008252	0.00005532495	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	0.036	0.0088	0.000058	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.061041	0.0151828	0.00005839046	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	-0.0331371	0.00825204	0.00005958286	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP13 protein levels (SeqId = 4925-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP13 protein levels (SeqId = 4925-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagenase 3	774	1	Adults (18-65 years)	Both	European	cg07464924	chr3:182817250	3	182817250	MCCC1	Island	0.19	0.046	0.00006	None	Gadd-DA_mmp13_protein_levels__seqid___4925-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0330211	0.00825207	0.00006323782	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	0.0330148	0.00825207	0.0000634412	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Kazmi N	PACE	31230546	2019-06-24	Hypertensive disorders of pregnancy	MONDO_0024664, EFO_0000537, EFO_0000668	Meta analysis unadjusted model	Table S3	DNA methylation	Hypertensive disorders of pregnancy	None	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	5242	10	Infants	Both	Unclear	cg08395365	chr3:182817479	3	182817479	MCCC1	South shore	-0.0024	0.0006	0.000064	None	31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg12518648	chr3:182816225	3	182816225	MCCC1	North shore	1.1	0.264	0.000066	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0603892	0.0151463	0.00006722221	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00890010	chr3:182817389	3	182817389	MCCC1	Island	-0.068489	0.0172358	0.00007106558	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	-0.0327847	0.00825213	0.00007134775	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0327541	0.00825214	0.00007246845	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Jenny van Dongen	BIOS consortium, GoDMC	34584077	Sep 28, 2021	monozygotic twinning	None	None	supplemental table 3	DNA methylation	monozygotic twinning	Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index	Beta values	None	Illumina HumanMethylation450	whole blood	we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method	5723	5	Adults (18-65 years)	Both	European	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	None	None	0.000075	None	34584077_Jenny-van-Dongen_monozygotic_twinning
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08395365	chr3:182817479	3	182817479	MCCC1	South shore	-0.0788187	0.0199197	0.00007625818	None	39706196_Hannah-M.-Smith_body_fat_discovery
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-0.002	0.001	0.0000777	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-0.0022	0.0006	0.000078	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.0333277	0.00843573	0.00007826101	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.059274	0.0150052	0.00007844543	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04991337	chr3:182817223	3	182817223	MCCC1	Island	-0.0533637	0.0135419	0.00008158464	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19080749	chr3:182733491	3	182733491	MCCC1	Open sea	0.0329389	0.00835898	0.00008167419	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0325152	0.00825221	0.00008179832	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	201	1	Adults	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	-0.0283	0.007	0.000083	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_current_smokers
Gadd DA	Generation Scotland	35945220	31/07/2022	GPNMB protein levels (SeqId = 8606-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPNMB protein levels (SeqId = 8606-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane glycoprotein NMB	774	1	Adults (18-65 years)	Both	European	cg03344955	chr3:182817626	3	182817626	MCCC1	South shore	-0.38	0.098	0.000083	None	Gadd-DA_gpnmb_protein_levels__seqid___8606-39__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	0.0324739	0.00825222	0.00008351972	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg23166970	chr3:182817578	3	182817578	MCCC1	South shore	-	-	0.0000883	-	26500701_sex_kora_f3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0323504	0.00825225	0.00008888199	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01212284	chr3:182814959	3	182814959	MCCC1	North shore	-0.0323441	0.00825225	0.0000891635	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12904680	chr3:182781611	3	182781611	MCCC1	North shore	0.269073	0.0687909	0.00009209287	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	SHH protein levels (SeqId = 2743-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHH protein levels (SeqId = 2743-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sonic hedgehog protein	774	1	Adults (18-65 years)	Both	European	cg00521899	chr3:182749158	3	182749158	MCCC1	Open sea	0.61	0.155	0.000093	None	Gadd-DA_shh_protein_levels__seqid___2743-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00598301	chr3:182812578	3	182812578	MCCC1	Open sea	-0.041098	0.0105135	0.000093063	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13192779	chr3:182756521	3	182756521	MCCC1	Open sea	0.0322427	0.00825228	0.00009382123	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids in medium VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg03318940	chr3:182817448	3	182817448	MCCC1	Island	-2.5	0.65	0.000094	None	Battram-T_phospholipids_in_medium_vldl
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg02616966	chr3:182817190	3	182817190	MCCC1	Island	-0.002	0.001	0.0000947	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Jenny van Dongen	BIOS consortium, GoDMC	34584077	Sep 28, 2021	monozygotic twinning	None	None	supplemental table 3	DNA methylation	monozygotic twinning	Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index	Beta values	None	Illumina HumanMethylation450	whole blood	we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method	5723	5	Adults (18-65 years)	Both	European	cg00161968	chr3:182817338	3	182817338	MCCC1	Island	None	None	0.000096	None	34584077_Jenny-van-Dongen_monozygotic_twinning