author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00575529	chr6:30685080	6	30685080	MDC1	Island	0.00048	0.000056	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05300316	chr6:30685246	6	30685246	MDC1	Island	0.0004	0.000044	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.00041	0.000043	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0031	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0039	0.00027	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10277195	chr6:30684931	6	30684931	MDC1	Island	0.00082	0.000073	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0022	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12814525	chr6:30685250	6	30685250	MDC1	Island	0.00048	0.000056	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16580700	chr6:30685744	6	30685744	MDC1	South shore	-0.0015	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17188180	chr6:30684840	6	30684840	MDC1	Island	-0.00012	0.000013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17302862	chr6:30685540	6	30685540	MDC1	South shore	-0.00048	0.000055	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	-0.004	0.00025	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	0.016	0.0016	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27369934	chr6:30684905	6	30684905	MDC1	Island	-0.00021	0.000021	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26454601	chr6:30683823	6	30683823	MDC1	North shore	0.0015	None	1.7e-116	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.3901	0.00755	6.1e-115	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.23178	0.00464	2.1e-112	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	0.31314	0.00679	3.8e-106	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.09147	0.002	1.6999999999999998e-105	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.177795	0.00812502	1.777226e-104	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	0.09734	0.00217	5.9e-104	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	0.26823	0.00617	1.4000000000000001e-101	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01533397	chr6:30684278	6	30684278	MDC1	North shore	0.24506	0.00658	4.2e-90	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09232906	chr6:30684280	6	30684280	MDC1	North shore	0.16205	0.00485	3.7e-82	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.14853	0.00816499	3.864913e-73	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.133013	0.00818321	6.798993e-59	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0022	None	1.1e-52	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.121709	0.00819519	1.561523e-49	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16580700	chr6:30685744	6	30685744	MDC1	South shore	0.15888	0.00798	1.2e-48	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10511301	chr6:30683561	6	30683561	MDC1	North shore	0.04081	0.00216	1.2e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25988105	chr6:30681476	6	30681476	MDC1	North shelf	0.0024	None	3.1e-45	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-	-	7.45e-42	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.107863	0.0082084	3.208161e-39	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10925640	chr6:30684572	6	30684572	MDC1	North shore	0.1096	0.00687	4.4e-37	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.100544	0.00821473	2.812605e-34	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26454601	chr6:30683823	6	30683823	MDC1	North shore	0.0045	None	1.3000000000000001e-32	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10423170	chr6:30681943	6	30681943	MDC1	North shelf	0.03068	0.00213	1.7000000000000002e-32	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0967925	0.0082178	7.021712e-32	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.06539	0.00468	4.3e-31	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg01533397	chr6:30684278	6	30684278	MDC1	North shore	-	-	1.34e-29	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.092638	0.00822107	2.4814250000000002e-29	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21643358	chr6:30681110	6	30681110	MDC1	North shelf	0.04299	0.00336	1.7000000000000002e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0891746	0.00822368	2.7135020000000002e-27	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0011	None	1.1e-26	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0880585	0.0082245	1.1856739999999999e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0870975	0.00822519	4.158698e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0854755	0.00822635	3.3518830000000003e-25	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-	-	1.09e-24	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11281993	chr6:30682871	6	30682871	MDC1	North shore	0.0011	None	4.2e-24	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	0.0026	None	8.199999999999999e-24	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	-	-	1.66e-23	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07129907	chr6:30683787	6	30683787	MDC1	North shore	0.0008	None	5.5e-23	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0787875	0.00823091	1.211085e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0784031	0.00823116	1.900753e-21	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2901913 (gene symbol: TUBB)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2901913 (gene symbol: TUBB)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg16580700	chr6:30685744	6	30685744	MDC1	South shore	None	None	2.6e-21	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2901913__gene_symbol__tubb__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0773289	0.00823185	6.6206719999999996e-21	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0998061	0.0106886	1.124465e-20	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	ch.6.738234R	chr6:30679284	6	30679284	MDC1	Open sea	0.01018	0.00098	3e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0756741	0.0082329	4.3783439999999996e-20	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0750359	0.00823329	8.975204e-20	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0731637	0.00823444	7.119623999999999e-19	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.8012948	0.0917	2.33e-18	-	25888029_ageing
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0082	0.00094	2.4e-18	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0717381	0.0082353	3.328452e-18	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18512512	chr6:30685686	6	30685686	MDC1	South shore	0.04171	0.00438	7.2e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03563090	chr6:30684878	6	30684878	MDC1	Island	0.01186	0.0013	8.2e-17	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0671841	0.00823792	3.758099e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-	-	4.17e-16	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0653692	0.00823891	0.000000000000002270849	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.065335	0.00823893	0.000000000000002348064	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.038	0.00485	0.0000000000000031	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	-0.0019	0.00024	0.0000000000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0649718	0.00823913	0.000000000000003345435	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	0.03791	0.00444	0.0000000000000039	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18301048	chr6:30685243	6	30685243	MDC1	Island	0.00019	0.000024	0.0000000000000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0641861	0.00823955	0.000000000000007148394	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0832352	0.0107477	0.00000000000001022409	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0638051	0.00823975	0.00000000000001029597	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23590244	chr6:30685311	6	30685311	MDC1	Island	-0.000097	0.000013	0.000000000000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15622885	chr6:30685406	6	30685406	MDC1	Island	-0.000094	0.000012	0.000000000000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.212223	0.0281187	0.00000000000004660935	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0805323	0.0106803	0.00000000000004965987	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0620085	0.00824068	0.00000000000005591863	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.211237	0.0281837	0.00000000000006949495	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0615207	0.00824093	0.00000000000008780725	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11281993	chr6:30682871	6	30682871	MDC1	North shore	0.01577	0.00196	0.000000000000088	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0612922	0.00824105	0.0000000000001083442	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0608371	0.00824128	0.0000000000001643017	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0599848	0.0082417	0.0000000000003554474	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0089	0.0012	0.00000000000043	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.059305	0.00824204	0.0000000000006528432	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0587244	0.00824232	0.00000000000109132	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03157605	chr6:30685409	6	30685409	MDC1	Island	0.00036	None	0.0000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24134020	chr6:30681924	6	30681924	MDC1	North shelf	0.01117	0.00149	0.0000000000021	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0578399	0.00824275	0.000000000002365155	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0638245	0.00916598	0.000000000003467941	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07656347	chr6:30684837	6	30684837	MDC1	Island	0.00039	0.000057	0.0000000000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.00534	0.00077	0.0000000000037	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.124619	0.0180427	0.000000000005158038	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00682802	chr6:30682855	6	30682855	MDC1	North shore	-0.01335	0.00184	0.0000000000091	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.212327	0.0311197	0.00000000000921651	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0557508	0.00824373	0.00000000001404601	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.02815	0.0042	0.0000000000151	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.122041	0.0180752	0.00000000001514247	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.041	0.00603	0.000000000016	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.071184	0.0105773	0.00000000001761337	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0549783	0.00824408	0.00000000002671004	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0548572	0.00824414	0.00000000002951696	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0548514	0.00824414	0.0000000000296582	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10277195	chr6:30684931	6	30684931	MDC1	Island	0.00077	None	0.000000000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.233845	0.0353605	0.00000000003871446	None	39706196_Hannah-M.-Smith_bmi_discovery
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.73255804	0.1111	0.0000000000421	-	25888029_ageing
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.054105	0.00824448	0.00000000005466213	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2948564 (gene symbol: MDC1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2948564 (gene symbol: MDC1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg26193015	chr6:30683144	6	30683144	MDC1	North shore	None	None	0.000000000058	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2948564__gene_symbol__mdc1__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15024975	chr6:30685170	6	30685170	MDC1	Island	0.00039	0.00006	0.000000000064	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.202387	0.0310522	0.00000000007340439	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0537408	0.00824464	0.00000000007344778	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	0.0019	None	0.000000000081	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.228698	0.0353348	0.00000000009911413	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18512512	chr6:30685686	6	30685686	MDC1	South shore	-0.0011	0.00016	0.0000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21643358	chr6:30681110	6	30681110	MDC1	North shelf	0.0013	0.00021	0.00000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.114907	0.0178823	0.0000000001353073	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.00466	0.00073	0.00000000017	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19483962	chr6:30681100	6	30681100	MDC1	North shelf	-2.308801	0.362	0.000000000179	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0577782	0.00916605	0.000000000299331	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.0015	0.00024	0.00000000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg09232906	chr6:30684280	6	30684280	MDC1	North shore	-1.843435	0.2942	0.000000000371	-	27105112_hiv_infection_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg11968414	chr6:30684868	6	30684868	MDC1	Island	0.01738	0.0028	0.000000000429	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0665994	0.0106609	0.0000000004297393	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.113748	0.0182306	0.000000000451319	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg18512512	chr6:30685686	6	30685686	MDC1	South shore	0.03005	0.0048	0.000000000458	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0511611	0.00824576	0.0000000005633221	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13983052	chr6:30685120	6	30685120	MDC1	Island	0.00797	0.00122	0.0000000006	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.050932	0.00824586	0.0000000006719291	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0509059	0.00824587	0.0000000006854929	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0508729	0.00824588	0.0000000007031104	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg21643358	chr6:30681110	6	30681110	MDC1	North shelf	-2.247348	0.3648	0.000000000725	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25988105	chr6:30681476	6	30681476	MDC1	North shelf	-0.0012	0.0002	0.00000000074	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0655461	0.0107133	0.0000000009704634	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.00373	0.00062	0.0000000016	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	0.01122	0.0019	0.00000000164	-	23334450_rheumatoid_arthritis
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-1.7	0.276	0.0000000017	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19483962	chr6:30681100	6	30681100	MDC1	North shelf	0.0167	0.00264	0.0000000017	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0493762	0.0082465	0.000000002180275	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0055	None	0.0000000024	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0633945	0.0106942	0.000000003136609	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10925640	chr6:30684572	6	30684572	MDC1	North shore	-0.0016	0.00027	0.0000000039	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.105991	0.0180301	0.000000004228888	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0539244	0.00918424	0.000000004414608	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0483656	0.00824691	0.000000004596383	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24134020	chr6:30681924	6	30681924	MDC1	North shelf	0.00041	None	0.0000000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	0.155989	0.0266093	0.000000004646583	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0624064	0.0106917	0.000000005430831	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.011	0.0018	0.0000000056	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0480599	0.00824703	0.000000005743084	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.163691	0.0281155	0.000000005914603	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0478272	0.00824712	0.000000006797936	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0475141	0.00824725	0.000000008518986	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0526061	0.00913545	0.000000008658765	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0614309	0.0106803	0.00000000900746	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0473906	0.00824729	0.000000009308338	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	0.00042	0.000074	0.00000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg13983052	chr6:30685120	6	30685120	MDC1	Island	0.0079	0.0014	0.0000000103	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0470787	0.00824742	0.000000011632	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20835659	chr6:30681672	6	30681672	MDC1	North shelf	0.03325	0.00558	0.000000012	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	0.0095	0.0017	0.000000014	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg04181831	chr6:30684873	6	30684873	MDC1	Island	-1.452609	0.2566	0.000000015	-	27105112_hiv_infection_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg26568546	chr6:30682678	6	30682678	MDC1	North shelf	-0.01349	0.0024	0.0000000155	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0518989	0.00917624	0.00000001580264	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0465849	0.00824761	0.00000001650538	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0470525	0.0083409	0.00000001720085	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0594659	0.010568	0.0000000186782	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26454601	chr6:30683823	6	30683823	MDC1	North shore	-0.00851	0.00145	0.00000002	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-3.3	0.589	0.000000025	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13983052	chr6:30685120	6	30685120	MDC1	Island	0.00023	None	0.000000025	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0464723	0.00834664	0.00000002625221	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	0.02361	0.0042	0.0000000264	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0507462	0.00912883	0.00000002762303	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.101795	0.0183233	0.00000002816495	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0457394	0.00824793	0.00000002980749	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00682802	chr6:30682855	6	30682855	MDC1	North shore	0.00056	None	0.00000003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0455436	0.008248	0.00000003412945	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07129907	chr6:30683787	6	30683787	MDC1	North shore	0.0024	None	0.000000039	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.03	0.00554	0.000000046	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.00088	0.00016	0.000000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0450595	0.00824819	0.00000004759067	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0455649	0.00834456	0.00000004826976	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0450024	0.00824821	0.00000004947973	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0448582	0.00824826	0.00000005458926	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg26552907	chr6:30667625	6	30667625	MDC1	Open sea	-0.03615	0.0067	0.000000056	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	0.0026	0.00048	0.000000057	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10277195	chr6:30684931	6	30684931	MDC1	Island	0.0023	0.00043	0.000000062	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0445729	0.00824837	0.0000000662445	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11968414	chr6:30684868	6	30684868	MDC1	Island	0.00046	0.000086	0.000000069	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg12814525	chr6:30685250	6	30685250	MDC1	Island	-	-	0.0000000851	-	26857698_primary_sjogrens_syndrome_whole_blood
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07656347	chr6:30684837	6	30684837	MDC1	Island	0.00881	0.00158	0.000000087	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0439271	0.0082486	0.000000102219	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg24134020	chr6:30681924	6	30681924	MDC1	North shelf	-0.01114	0.0021	0.000000105	-	23334450_rheumatoid_arthritis
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg01533397	chr6:30684278	6	30684278	MDC1	North shore	-	-	0.000000107	-	26857698_primary_sjogrens_syndrome_whole_blood
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0053	0.001	0.00000012	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0484503	0.00914989	0.0000001206205	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22596454	chr6:30685146	6	30685146	MDC1	Island	0.00032	0.000061	0.00000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0434132	0.00824879	0.0000001437335	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0434086	0.00824879	0.0000001441732	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0064	0.0012	0.00000019	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0538903	0.0103581	0.0000001990491	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22596454	chr6:30685146	6	30685146	MDC1	Island	0.1538	0.0295996	0.0000002057987	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.047834	0.00921014	0.0000002090024	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10816127	chr6:30685626	6	30685626	MDC1	South shore	-0.00036	0.000069	0.00000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12814525	chr6:30685250	6	30685250	MDC1	Island	0.0019	0.00036	0.00000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22782446	chr6:30685087	6	30685087	MDC1	Island	0.00021	None	0.00000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.178654	0.0345979	0.000000244756	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.038	0.00731	0.00000027	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.00026	0.000051	0.00000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.159295	0.0310425	0.0000002905105	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg05317081	chr6:30685534	6	30685534	MDC1	South shore	-1.258727	0.2461	0.000000315	-	27105112_hiv_infection_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg24700494	chr6:30684284	6	30684284	MDC1	North shore	-1.154209	0.2261	0.00000033	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09232906	chr6:30684280	6	30684280	MDC1	North shore	-0.00078	0.00015	0.00000034	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0420732	0.00824926	0.0000003434479	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0420407	0.00824927	0.0000003506871	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg01533397	chr6:30684278	6	30684278	MDC1	North shore	-1.315529	0.259	0.000000379	-	27105112_hiv_infection_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.173408	0.0341888	0.0000003975669	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0417298	0.00824938	0.0000004275817	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00575529	chr6:30685080	6	30685080	MDC1	Island	0.0018	0.00036	0.00000048	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10511301	chr6:30683561	6	30683561	MDC1	North shore	0.0014	None	0.0000005	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0534072	0.0106899	0.0000005918462	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	None	None	0.00000074	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0408023	0.0082497	0.0000007662728	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.0014	0.00028	0.00000078	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	TTC9B protein levels (SeqId = 9386-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TTC9B protein levels (SeqId = 9386-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tetratricopeptide repeat protein 9B	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.82	0.167	0.00000085	None	Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0527337	0.010711	0.0000008600868	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0038	0.00078	0.00000088	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.026	0.00535	0.00000089	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.040767	0.00829586	0.0000009013681	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0449324	0.00916917	0.0000009667581	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11281993	chr6:30682871	6	30682871	MDC1	North shore	0.003	None	0.00000097	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.0404016	0.00824983	0.0000009821618	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0511791	0.0104515	0.000000984469	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0402448	0.00824988	0.000001081697	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0402884	0.00829054	0.000001188642	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	-0.13004	0.02682	0.000001254024	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0403685	0.00834475	0.000001327582	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0399005	0.00825	0.000001335356	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DRAXIN protein levels (SeqId = 7084-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DRAXIN protein levels (SeqId = 7084-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Draxin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.8	0.166	0.0000014	None	Gadd-DA_draxin_protein_levels__seqid___7084-1__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22596454	chr6:30685146	6	30685146	MDC1	Island	0.002	0.00041	0.0000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0398521	0.00831276	0.000001650243	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0440743	0.00920526	0.000001701371	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0394313	0.00825015	0.000001774706	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0024	None	0.0000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26193015	chr6:30683144	6	30683144	MDC1	North shore	0.0011	None	0.0000018	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.0392604	0.00825021	0.00000196684	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.0056	0.00114	0.000002	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0391591	0.00825024	0.000002090016	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.119323	0.02517	0.000002150001	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	0.0022	None	0.0000022	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0389429	0.00825031	0.000002378171	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.038879	0.00825033	0.000002470479	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10925640	chr6:30684572	6	30684572	MDC1	North shore	0.0388136	0.00825035	0.000002568355	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRRG1 protein levels (SeqId = 9008-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRRG1 protein levels (SeqId = 9008-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane gamma-carboxyglutamic acid protein 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.785	0.167	0.0000026	None	Gadd-DA_prrg1_protein_levels__seqid___9008-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0387736	0.00825036	0.00000263007	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11281993	chr6:30682871	6	30682871	MDC1	North shore	-0.00054	0.00012	0.0000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.04294	0.00918825	0.000002989476	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0498881	0.0106874	0.000003069366	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0384984	0.00825045	0.000003095009	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	-0.124712	0.0267601	0.000003180034	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0384513	0.00825047	0.000003182094	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0426881	0.00917268	0.000003286639	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0383717	0.00825049	0.0000033348	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05300316	chr6:30685246	6	30685246	MDC1	Island	0.0014	0.00029	0.0000034	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03157605	chr6:30685409	6	30685409	MDC1	Island	-1.358443	0.2928	0.0000035	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0499938	0.0107893	0.000003623823	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0386069	0.00833517	0.00000365601	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0454082	0.00980789	0.000003692209	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.013	0.00287	0.0000037	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.0381336	0.00825057	0.000003834225	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0381	0.00825058	0.000003910018	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.0406396	0.00880696	0.000003973945	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0422706	0.00918836	0.000004251138	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0379508	0.00825062	0.000004265491	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.194689	0.0423449	0.000004302025	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09859103	chr6:30685402	6	30685402	MDC1	Island	0.0067	0.00142	0.0000044	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.0378635	0.00825065	0.000004487457	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09232906	chr6:30684280	6	30684280	MDC1	North shore	0.005	0.0011	0.0000046	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0378042	0.00825067	0.000004644525	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26552907	chr6:30667625	6	30667625	MDC1	Open sea	0.01575	0.00335	0.0000048	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-	-	0.00000485	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.037759	0.00827356	0.000005063876	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0376306	0.00825072	0.000005135112	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0378707	0.00830531	0.000005161275	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.145819	0.0319872	0.000005182839	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03563090	chr6:30684878	6	30684878	MDC1	Island	0.0013	None	0.0000052	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00682802	chr6:30682855	6	30682855	MDC1	North shore	-0.00038	0.000084	0.0000057	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0373748	0.0082508	0.000005949379	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23886643	chr6:30670957	6	30670957	MDC1	Open sea	-0.0373316	0.00825082	0.000006098777	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CRIM1 protein levels (SeqId = 8699-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRIM1 protein levels (SeqId = 8699-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich motor neuron 1 protein	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.75	0.167	0.0000064	None	Gadd-DA_crim1_protein_levels__seqid___8699-43__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.037404	0.00829292	0.00000652203	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0475247	0.010562	0.000006861233	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0369736	0.00825093	0.000007480569	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MRAS protein levels (SeqId = 18297-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRAS protein levels (SeqId = 18297-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein M-Ras	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.75	0.167	0.0000075	None	Gadd-DA_mras_protein_levels__seqid___18297-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0480518	0.0107286	0.000007561386	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23485400	chr6:30685229	6	30685229	MDC1	Island	0.00037	None	0.0000076	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0369151	0.00825094	0.000007732874	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg26454601	chr6:30683823	6	30683823	MDC1	North shore	-0.142734	0.031921	0.000007815012	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	NEURL4 protein levels (SeqId = 13468-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEURL4 protein levels (SeqId = 13468-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuralized-like protein 4	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.74	0.17	0.0000081	None	Gadd-DA_neurl4_protein_levels__seqid___13468-5__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06074256	chr6:30684939	6	30684939	MDC1	Island	-0.000073	0.000016	0.0000085	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannon E	-	27572077	2016-08-30	Schizophrenia	EFO_0000692	Phase 1	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	675	1	-	Missing	European	cg26509254	chr6:30685303	6	30685303	MDC1	Island	0.005477	0.001231	0.00000863	-	27572077_schizophrenia_phase_1
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	metolachlor	None	discovery	10.5281/zenodo.5156585	DNA methylation	metolachlor	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	507	1	Adults	Males	European	cg23590244	chr6:30685311	6	30685311	MDC1	Island	-0.0017	0.00038	0.0000087	None	34516295_Hoang_metolachlor_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.310665	0.0701	0.00000939	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	0.0361254	0.00816997	0.000009861473	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg10277195	chr6:30684931	6	30684931	MDC1	Island	-0.0448	0.00991	0.00001	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	None	None	0.00001	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Hannon E	-	27572077	2016-08-30	Schizophrenia	EFO_0000692	Phase 1	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	675	1	-	Missing	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	0.005603	0.001269	0.00001	-	27572077_schizophrenia_phase_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0477692	0.0108119	0.00001002449	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg10277195	chr6:30684931	6	30684931	MDC1	Island	0.0571	0.0125	0.000011	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.0362684	0.00825114	0.00001112656	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0001528	3.48e-05	0.0000113	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0361864	0.00825116	0.00001164672	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0474214	0.0108179	0.0000117532	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07656347	chr6:30684837	6	30684837	MDC1	Island	0.0378407	0.00863732	0.00001189186	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	MYNN protein levels (SeqId = 12455-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MYNN protein levels (SeqId = 12455-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myoneurin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.73	0.167	0.000012	None	Gadd-DA_mynn_protein_levels__seqid___12455-48__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.036117	0.00825118	0.00001210536	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0394103	0.00901819	0.00001250497	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0467564	0.0107119	0.00001280397	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0360145	0.00825122	0.00001281379	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SPSB1 protein levels (SeqId = 13942-140)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPSB1 protein levels (SeqId = 13942-140)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SPRY domain-containing SOCS box protein 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.727	0.167	0.000013	None	Gadd-DA_spsb1_protein_levels__seqid___13942-140__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2B protein levels (SeqId = 9865-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2B protein levels (SeqId = 9865-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 B	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.72	0.167	0.000014	None	Gadd-DA_ube2b_protein_levels__seqid___9865-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR1C3 protein levels (SeqId = 17377-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR1C3 protein levels (SeqId = 17377-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldo-keto reductase family 1 member C3	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.72	0.167	0.000014	None	Gadd-DA_akr1c3_protein_levels__seqid___17377-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALK protein levels (SeqId = 8249-124)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALK protein levels (SeqId = 8249-124)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ALK tyrosine kinase receptor	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.72	0.17	0.000014	None	Gadd-DA_alk_protein_levels__seqid___8249-124__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCL2 protein levels (SeqId = 14192-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCL2 protein levels (SeqId = 14192-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosducin-like protein 2	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.72	0.167	0.000015	None	Gadd-DA_pdcl2_protein_levels__seqid___14192-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0357272	0.0082513	0.00001501792	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0357237	0.0082513	0.00001504649	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	-0.0356433	0.00825133	0.00001572626	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.035616	0.00825133	0.00001596401	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0460526	0.0106926	0.00001665951	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0779424	0.0181065	0.00001683159	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12814525	chr6:30685250	6	30685250	MDC1	Island	0.140718	0.0327038	0.00001695349	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07656347	chr6:30684837	6	30684837	MDC1	Island	0.0016	0.00038	0.000017	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0356501	0.00830698	0.00001785401	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	ch.6.738234R	chr6:30679284	6	30679284	MDC1	Open sea	-0.808404	0.1885	0.000018	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0353933	0.0082514	0.00001803276	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.0353862	0.0082514	0.00001810239	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0393656	0.00918024	0.00001813757	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0357655	0.00834652	0.00001838437	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0457592	0.0106846	0.0000185801	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0353178	0.00825142	0.00001879084	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0352849	0.00825143	0.00001912988	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0354163	0.00829385	0.0000196535	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-1.42	0.33	0.00002	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Gadd DA	Generation Scotland	35945220	31/07/2022	AURKA protein levels (SeqId = 3091-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AURKA protein levels (SeqId = 3091-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aurora kinase A	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.71	0.167	0.00002	None	Gadd-DA_aurka_protein_levels__seqid___3091-70__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.146651	0.0343835	0.00002008122	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0353581	0.00830326	0.0000207237	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0350735	0.00825149	0.00002145542	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KLHL13 protein levels (SeqId = 12463-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLHL13 protein levels (SeqId = 12463-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kelch-like protein 13	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.71	0.167	0.000022	None	Gadd-DA_klhl13_protein_levels__seqid___12463-7__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13983052	chr6:30685120	6	30685120	MDC1	Island	0.00014	0.000032	0.000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.044888	0.0105946	0.00002280569	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	BTLA protein levels (SeqId = 16308-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTLA protein levels (SeqId = 16308-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: B- and T-lymphocyte attenuator	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.71	0.167	0.000023	None	Gadd-DA_btla_protein_levels__seqid___16308-14__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18301048	chr6:30685243	6	30685243	MDC1	Island	0.00043	None	0.000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-2.1	0.502	0.000023	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0349135	0.00825154	0.0000233906	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10925640	chr6:30684572	6	30684572	MDC1	North shore	-0.013	0.003	0.000024	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0455596	0.0107834	0.00002404237	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0348396	0.00825156	0.00002434022	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0348057	0.00825157	0.00002478815	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22724063	chr6:30684760	6	30684760	MDC1	North shore	-0.112768	0.0267423	0.00002490011	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Panni T	-	26731791	2016-07-01	Air pollution exposure	EFO_0008255	28-day trailing average particle matter concentration	Additional file 1	DNA methylation	Air pollution exposure	Age, sex, smoking, income, alcohol consumption, body mass index, cell counts and technical covariates	Beta values	mug/m3	Illumina HumanMethylation450	Whole blood	Regression coefficients per 10-muy/m3 increase in paricle matter polution	2956	3	62.2	Both	European	cg00682802	chr6:30682855	6	30682855	MDC1	North shore	0.00227	0.000539	0.0000252	-	26731791_air_pollution_exposure_28day_trailing_average_particle_matter_concentration
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0349347	0.00829817	0.0000256973	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.0349155	0.00829528	0.0000257934	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	METTL1 protein levels (SeqId = 12514-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	METTL1 protein levels (SeqId = 12514-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: tRNA (guanine-N(7)-)-methyltransferase	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.7	0.167	0.000026	None	Gadd-DA_mettl1_protein_levels__seqid___12514-16__somascan_protein_measurement
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	CD14+ monocytes	Table S7	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	CD14+ monocytes	-	1251	1	60	Both	European,African,Admixed	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.000335	7.93e-05	0.000026	-	27843151_alcohol_consumption_per_day_cd14_monocytes
Gadd DA	Generation Scotland	35945220	31/07/2022	VAMP8 protein levels (SeqId = 7064-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAMP8 protein levels (SeqId = 7064-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vesicle-associated membrane protein 8	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.7	0.167	0.000027	None	Gadd-DA_vamp8_protein_levels__seqid___7064-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0347681	0.00828361	0.00002718033	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0346075	0.00825163	0.0000275664	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00682802	chr6:30682855	6	30682855	MDC1	North shore	0.0018	None	0.000028	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CD81 protein levels (SeqId = 19612-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD81 protein levels (SeqId = 19612-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD81 antigen	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.7	0.167	0.000028	None	Gadd-DA_cd81_protein_levels__seqid___19612-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SF3B4 protein levels (SeqId = 13449-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SF3B4 protein levels (SeqId = 13449-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Splicing factor 3B subunit 4	774	1	Adults (18-65 years)	Both	European	cg23590244	chr6:30685311	6	30685311	MDC1	Island	-0.6	0.144	0.000028	None	Gadd-DA_sf3b4_protein_levels__seqid___13449-25__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.0368328	0.00879221	0.00002815123	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GMPR protein levels (SeqId = 19254-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GMPR protein levels (SeqId = 19254-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GMP reductase 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.69	0.165	0.000029	None	Gadd-DA_gmpr_protein_levels__seqid___19254-125__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg17188180	chr6:30684840	6	30684840	MDC1	Island	-0.876616	0.2099	0.0000298	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ZDHHC14 protein levels (SeqId = 11677-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZDHHC14 protein levels (SeqId = 11677-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable palmitoyltransferase ZDHHC14	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.7	0.167	0.00003	None	Gadd-DA_zdhhc14_protein_levels__seqid___11677-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0348895	0.00836315	0.00003039243	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.001	None	0.000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PRC1 protein levels (SeqId = 15310-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRC1 protein levels (SeqId = 15310-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein regulator of cytokinesis 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.7	0.167	0.000031	None	Gadd-DA_prc1_protein_levels__seqid___15310-61__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0343702	0.00825169	0.00003128192	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00575529	chr6:30685080	6	30685080	MDC1	Island	0.0343083	0.00825171	0.00003232688	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04406101	chr6:30670340	6	30670340	MDC1	Open sea	-0.17335	0.0417242	0.00003272547	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.026	0.00629	0.000033	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0342261	0.00825173	0.0000337658	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0754173	0.0181861	0.00003388078	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF174 protein levels (SeqId = 11486-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF174 protein levels (SeqId = 11486-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 174	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.69	0.167	0.000034	None	Gadd-DA_znf174_protein_levels__seqid___11486-26__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19187854	chr6:30670795	6	30670795	MDC1	Open sea	-0.210851	0.0509773	0.00003547191	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-1.2	0.286	0.000036	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05300316	chr6:30685246	6	30685246	MDC1	Island	0.00026	None	0.000037	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.0008	None	0.000037	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	None	None	0.000038	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0378298	0.00918138	0.00003805086	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ANGPTL1 protein levels (SeqId = 9092-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANGPTL1 protein levels (SeqId = 9092-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Angiopoietin-related protein 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.69	0.167	0.000039	None	Gadd-DA_angptl1_protein_levels__seqid___9092-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0339355	0.00825182	0.00003935402	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA2 protein levels (SeqId = 5756-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA2 protein levels (SeqId = 5756-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-2	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.69	0.167	0.00004	None	Gadd-DA_pappa2_protein_levels__seqid___5756-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TENM4 protein levels (SeqId = 11365-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TENM4 protein levels (SeqId = 11365-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Teneurin-4	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.683	0.166	0.00004	None	Gadd-DA_tenm4_protein_levels__seqid___11365-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	1.17	0.286	0.00004	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.035	0.00859	0.000041	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0439126	0.0107058	0.00004122084	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05546064	chr6:30685074	6	30685074	MDC1	Island	0.138819	0.0338713	0.00004177899	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0341839	0.00834246	0.00004197286	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00575529	chr6:30685080	6	30685080	MDC1	Island	0.00453	0.00108	0.000042	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR1C1 protein levels (SeqId = 12618-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR1C1 protein levels (SeqId = 12618-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldo-keto reductase family 1 member C1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.68	0.17	0.000042	None	Gadd-DA_akr1c1_protein_levels__seqid___12618-50__somascan_protein_measurement
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	None	None	0.000042	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.465645	0.1138	0.0000427	None	27105112_hiv_infection_cd4_tcells
Gadd DA	Generation Scotland	35945220	31/07/2022	IL27 protein levels (SeqId = 2829-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL27 protein levels (SeqId = 2829-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-27 subunit beta|Interleukin-27 subunit alpha	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.681	0.166	0.000043	None	Gadd-DA_il27_protein_levels__seqid___2829-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0374608	0.0091603	0.00004346617	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22596454	chr6:30685146	6	30685146	MDC1	Island	0.241153	0.0589978	0.0000438029	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0374899	0.0091729	0.0000439253	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TXN protein levels (SeqId = 8813-160)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXN protein levels (SeqId = 8813-160)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.68	0.167	0.000044	None	Gadd-DA_txn_protein_levels__seqid___8813-160__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0337174	0.00825188	0.0000441159	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.144783	0.0354691	0.00004485962	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	GCH1 protein levels (SeqId = 11185-145)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GCH1 protein levels (SeqId = 11185-145)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GTP cyclohydrolase 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.68	0.167	0.000046	None	Gadd-DA_gch1_protein_levels__seqid___11185-145__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRTM2 protein levels (SeqId = 8906-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRTM2 protein levels (SeqId = 8906-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat and transmembrane domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.68	0.17	0.000046	None	Gadd-DA_lrtm2_protein_levels__seqid___8906-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNMD protein levels (SeqId = 6578-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNMD protein levels (SeqId = 6578-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tenomodulin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.68	0.167	0.000047	None	Gadd-DA_tnmd_protein_levels__seqid___6578-29__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15024975	chr6:30685170	6	30685170	MDC1	Island	0.0016	0.0004	0.000047	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0371955	0.00915103	0.00004836102	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	None	None	0.000049	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.033911	0.00835542	0.00004963158	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01533397	chr6:30684278	6	30684278	MDC1	North shore	0.004	0.00098	0.00005	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26509254	chr6:30685303	6	30685303	MDC1	Island	0.0017	0.00043	0.000051	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	-0.033409	0.00825196	0.00005178652	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RPP30 protein levels (SeqId = 17511-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPP30 protein levels (SeqId = 17511-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonuclease P protein subunit p30	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.167	0.000053	None	Gadd-DA_rpp30_protein_levels__seqid___17511-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04381681	chr6:30681593	6	30681593	MDC1	North shelf	0.0332772	0.008252	0.00005543644	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LSM1 protein levels (SeqId = 17795-176)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LSM1 protein levels (SeqId = 17795-176)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: U6 snRNA-associated Sm-like protein LSm1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.167	0.000056	None	Gadd-DA_lsm1_protein_levels__seqid___17795-176__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STK17B protein levels (SeqId = 5249-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STK17B protein levels (SeqId = 5249-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase 17B	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.167	0.000056	None	Gadd-DA_stk17b_protein_levels__seqid___5249-31__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.051	0.0127	0.000056	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Battram T	GEO	30045751	2020-09-15	Alzheimer's disease	EFO_0000249	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE66351	None	DNA methylation	Alzheimer's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Brain	Some brain tissue was cell sorted, but all data analysed together for this re-analysis of GEO data.	190	1	Geriatrics	Both	Unclear	cg21105955	chr6:30684478	6	30684478	MDC1	North shore	0.0268	0.00648	0.000057	None	30045751_Battram-T_alzheimer_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse66351
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0331951	0.00825202	0.00005783242	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	0.033194	0.00825202	0.00005786612	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	None	None	0.000059	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0368404	0.009172	0.00005933429	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0737908	0.0184169	0.00006188034	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FANCL protein levels (SeqId = 10063-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FANCL protein levels (SeqId = 10063-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase FANCL	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.17	0.000063	None	Gadd-DA_fancl_protein_levels__seqid___10063-10__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.109371	0.0273368	0.00006335618	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0329865	0.00825208	0.00006436686	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BMX protein levels (SeqId = 3414-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BMX protein levels (SeqId = 3414-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytoplasmic tyrosine-protein kinase BMX	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.167	0.000065	None	Gadd-DA_bmx_protein_levels__seqid___3414-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL36B protein levels (SeqId = 14149-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL36B protein levels (SeqId = 14149-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-36 beta	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.67	0.167	0.000065	None	Gadd-DA_il36b_protein_levels__seqid___14149-9__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.056	0.014	0.000066	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Gervin K	-	28785368	2017-08-02	Attention deficit hyperactivity disorder	EFO_0003888	Long-term prenatal exposure to paracetamol versus controls	Table S1	DNA methylation	Long-term prenatal exposure to paracetamol in children with ADHD versus controls	Sex, smoking, maternal age, gestational age, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	115	1	0	Both	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	-	-	0.0000667	-	28785368_attention_deficit_hyperactivity_disorder_longterm_prenatal_exposure_to_paracetamol_versus_controls
Gadd DA	Generation Scotland	35945220	31/07/2022	JMJD6 protein levels (SeqId = 18322-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	JMJD6 protein levels (SeqId = 18322-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000068	None	Gadd-DA_jmjd6_protein_levels__seqid___18322-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.042888	0.0107708	0.00006870577	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SPHK2 protein levels (SeqId = 4468-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPHK2 protein levels (SeqId = 4468-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sphingosine kinase 2	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000069	None	Gadd-DA_sphk2_protein_levels__seqid___4468-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPLN protein levels (SeqId = 11254-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPLN protein levels (SeqId = 11254-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Papilin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.664	0.167	0.000069	None	Gadd-DA_papln_protein_levels__seqid___11254-13__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.135242	0.0339783	0.00006912663	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	0.0425554	0.0106937	0.00006939972	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0331156	0.00833102	0.00007072282	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14029839	chr6:30685271	6	30685271	MDC1	Island	0.0327955	0.00825213	0.0000709597	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.024	0.00605	0.000071	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM173A protein levels (SeqId = 7148-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM173A protein levels (SeqId = 7148-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein N-lysine methyltransferase FAM173A	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000071	None	Gadd-DA_fam173a_protein_levels__seqid___7148-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SIRT3 protein levels (SeqId = 17495-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIRT3 protein levels (SeqId = 17495-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.166	0.000071	None	Gadd-DA_sirt3_protein_levels__seqid___17495-141__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0327445	0.00825214	0.00007282317	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0329835	0.00831352	0.00007298973	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CDH15 protein levels (SeqId = 5410-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDH15 protein levels (SeqId = 5410-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cadherin-15	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000073	None	Gadd-DA_cdh15_protein_levels__seqid___5410-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23886643	chr6:30670957	6	30670957	MDC1	Open sea	-0.0327204	0.00825215	0.00007372242	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26552907	chr6:30667625	6	30667625	MDC1	Open sea	-0.0327189	0.00825215	0.00007377821	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11968414	chr6:30684868	6	30684868	MDC1	Island	0.00049	None	0.000074	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0362974	0.00915922	0.00007438338	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CNTNAP5 protein levels (SeqId = 9044-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNTNAP5 protein levels (SeqId = 9044-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Contactin-associated protein-like 5	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.166	0.000075	None	Gadd-DA_cntnap5_protein_levels__seqid___9044-1__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	ch.6.738234R	chr6:30679284	6	30679284	MDC1	Open sea	0.00038	None	0.000075	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ARSK protein levels (SeqId = 8269-327)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARSK protein levels (SeqId = 8269-327)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Arylsulfatase K	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000076	None	Gadd-DA_arsk_protein_levels__seqid___8269-327__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DPYSL5 protein levels (SeqId = 12683-156)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DPYSL5 protein levels (SeqId = 12683-156)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dihydropyrimidinase-related protein 5	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000076	None	Gadd-DA_dpysl5_protein_levels__seqid___12683-156__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	0.0330759	0.00836056	0.00007651579	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SUSD1 protein levels (SeqId = 9582-93)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUSD1 protein levels (SeqId = 9582-93)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sushi domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.659	0.167	0.000077	None	Gadd-DA_susd1_protein_levels__seqid___9582-93__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05317081	chr6:30685534	6	30685534	MDC1	South shore	0.0326318	0.00825217	0.00007710958	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg16580700	chr6:30685744	6	30685744	MDC1	South shore	-0.0006999	0.00017639	0.0000773	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	0.0419335	0.0106097	0.00007774054	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0330949	0.00838092	0.00007889712	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07129907	chr6:30683787	6	30683787	MDC1	North shore	0.145899	0.0369492	0.00007890709	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0719703	0.0182511	0.00008073031	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0726163	0.0184181	0.00008095744	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB39B protein levels (SeqId = 12403-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB39B protein levels (SeqId = 12403-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-39B	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000081	None	Gadd-DA_rab39b_protein_levels__seqid___12403-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PC protein levels (SeqId = 13990-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PC protein levels (SeqId = 13990-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyruvate carboxylase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000082	None	Gadd-DA_pc_protein_levels__seqid___13990-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26158287	chr6:30685461	6	30685461	MDC1	Island	-0.0327914	0.0083239	0.00008205671	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0326937	0.00830076	0.00008232568	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TBXAS1 protein levels (SeqId = 8098-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBXAS1 protein levels (SeqId = 8098-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thromboxane-A synthase	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000083	None	Gadd-DA_tbxas1_protein_levels__seqid___8098-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BNIP3 protein levels (SeqId = 7045-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BNIP3 protein levels (SeqId = 7045-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000083	None	Gadd-DA_bnip3_protein_levels__seqid___7045-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MANBA protein levels (SeqId = 6382-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MANBA protein levels (SeqId = 6382-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-mannosidase	774	1	Adults (18-65 years)	Both	European	cg23590244	chr6:30685311	6	30685311	MDC1	Island	-0.57	0.144	0.000083	None	Gadd-DA_manba_protein_levels__seqid___6382-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	-0.0695635	0.0176816	0.00008384795	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07257768	chr6:30684736	6	30684736	MDC1	North shore	-0.0418299	0.0106384	0.00008464324	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11498582	chr6:30684340	6	30684340	MDC1	North shore	-0.0324393	0.00825223	0.00008499045	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CUL9 protein levels (SeqId = 12991-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CUL9 protein levels (SeqId = 12991-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cullin-9	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000086	None	Gadd-DA_cul9_protein_levels__seqid___12991-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TPP1 protein levels (SeqId = 17691-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPP1 protein levels (SeqId = 17691-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tripeptidyl-peptidase 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000086	None	Gadd-DA_tpp1_protein_levels__seqid___17691-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AQP4 protein levels (SeqId = 11363-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AQP4 protein levels (SeqId = 11363-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aquaporin-4	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.66	0.167	0.000086	None	Gadd-DA_aqp4_protein_levels__seqid___11363-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CPT1B protein levels (SeqId = 11709-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CPT1B protein levels (SeqId = 11709-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carnitine O-palmitoyltransferase 1, muscle isoform	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000088	None	Gadd-DA_cpt1b_protein_levels__seqid___11709-29__somascan_protein_measurement
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg03844211	chr6:30684773	6	30684773	MDC1	North shore	-0.0036	9e-04	0.000089	-	27651444_smoking_current_vs_never_smoking
Gadd DA	Generation Scotland	35945220	31/07/2022	AGR2 protein levels (SeqId = 4959-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AGR2 protein levels (SeqId = 4959-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anterior gradient protein 2 homolog	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.00009	None	Gadd-DA_agr2_protein_levels__seqid___4959-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM162B protein levels (SeqId = 11163-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM162B protein levels (SeqId = 11163-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FAM162B	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.17	0.00009	None	Gadd-DA_fam162b_protein_levels__seqid___11163-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST6 protein levels (SeqId = 4429-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST6 protein levels (SeqId = 4429-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 6	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.166	0.000091	None	Gadd-DA_chst6_protein_levels__seqid___4429-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SYNJ2BP protein levels (SeqId = 17348-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYNJ2BP protein levels (SeqId = 17348-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synaptojanin-2-binding protein	774	1	Adults (18-65 years)	Both	European	cg23590244	chr6:30685311	6	30685311	MDC1	Island	-0.562	0.144	0.000091	None	Gadd-DA_synj2bp_protein_levels__seqid___17348-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SERF1A protein levels (SeqId = 7842-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERF1A protein levels (SeqId = 7842-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small EDRK-rich factor 1	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000092	None	Gadd-DA_serf1a_protein_levels__seqid___7842-52__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0420613	0.0107534	0.00009216055	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03151709	chr6:30686511	6	30686511	MDC1	North shore	0.0014	None	0.000094	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	KPNA4 protein levels (SeqId = 12698-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KPNA4 protein levels (SeqId = 12698-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Importin subunit alpha-3	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.166	0.000094	None	Gadd-DA_kpna4_protein_levels__seqid___12698-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUFU protein levels (SeqId = 17468-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUFU protein levels (SeqId = 17468-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Suppressor of fused homolog	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000094	None	Gadd-DA_sufu_protein_levels__seqid___17468-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0417003	0.0106804	0.00009489275	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02364450	chr6:30671881	6	30671881	MDC1	Open sea	0.0322019	0.00825229	0.00009575781	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07656347	chr6:30684837	6	30684837	MDC1	Island	0.0321969	0.00825229	0.00009599595	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CALR protein levels (SeqId = 5264-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CALR protein levels (SeqId = 5264-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calreticulin	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000096	None	Gadd-DA_calr_protein_levels__seqid___5264-65__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ASTL protein levels (SeqId = 7993-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASTL protein levels (SeqId = 7993-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Astacin-like metalloendopeptidase	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000096	None	Gadd-DA_astl_protein_levels__seqid___7993-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ASIC4 protein levels (SeqId = 6951-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASIC4 protein levels (SeqId = 6951-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acid-sensing ion channel 4	774	1	Adults (18-65 years)	Both	European	cg07229198	chr6:30685635	6	30685635	MDC1	South shore	-0.65	0.167	0.000097	None	Gadd-DA_asic4_protein_levels__seqid___6951-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	QPCT protein levels (SeqId = 7849-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	QPCT protein levels (SeqId = 7849-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutaminyl-peptide cyclotransferase	774	1	Adults (18-65 years)	Both	European	cg26509254	chr6:30685303	6	30685303	MDC1	Island	-0.68	0.176	0.000098	None	Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23886643	chr6:30670957	6	30670957	MDC1	Open sea	-0.0321438	0.0082523	0.0000985791	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315208	chr6:30684406	6	30684406	MDC1	North shore	-0.0418166	0.0107412	0.00009941073	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16253551	chr6:30685136	6	30685136	MDC1	Island	0.198778	0.0510695	0.00009967478	None	39706196_Hannah-M.-Smith_bmi_sensitivity