author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13278795 chr5:176738672 5 176738672 MXD3 Island 0.00059 0.000064 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.011 0.0013 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0023 0.00021 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.018 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.178169 0.00812447 6.4731990000000005e-105 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.167107 0.00814047 2.393545e-92 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.166749 0.00814097 5.913213e-92 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.17368 0.00485 4e-87 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.154491 0.00815744 4.7914139999999997e-79 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.143464 0.00817116 2.6099410000000002e-68 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.140658 0.00817449 1.0389299999999999e-65 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.134442 0.00818161 3.8770030000000005e-60 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.132683 0.00818357 1.31066e-58 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.132345 0.00818394 2.563937e-58 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09044296 chr5:176739296 5 176739296 MXD3 Island 0.06304 0.00274 2.7e-57 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.124995 0.00819182 3.633229e-52 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.12299 0.00819389 1.50012e-50 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -3.3 0.227 3.6e-48 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.117367 0.00819951 3.668124e-46 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.112931 0.00820375 7.563566e-43 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.109538 0.00820689 2.120437e-40 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.104543 0.00821133 6.188802e-37 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore - - 4.13e-34 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0997811 0.00821537 8.78701e-34 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0976283 0.00821713 2.09041e-32 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0972919 0.0082174 3.4082500000000004e-32 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00318495 chr5:176739903 5 176739903 MXD3 South shore -0.112618 0.00965941 2.839976e-31 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13278795 chr5:176738672 5 176738672 MXD3 Island 0.01572 0.00114 1.1000000000000001e-30 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.109211 0.00960077 7.415161e-30 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0914324 0.00843696 2.912393e-27 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0880754 0.00822448 1.159609e-26 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg06733329 chr5:176740039 5 176740039 MXD3 South shore -1.58813 0.10365 1.9500000000000002e-26 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0856041 0.00822626 2.84473e-25 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0844824 0.00822705 1.179797e-24 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00318495 chr5:176739903 5 176739903 MXD3 South shore -0.0848767 0.0083093 2.058055e-24 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00318495 chr5:176739903 5 176739903 MXD3 South shore -0.084487 0.00830943 3.327719e-24 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.00129551 0.00012504 4.96e-24 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00318495 chr5:176739903 5 176739903 MXD3 South shore -0.0832874 0.00822788 5.2604669999999996e-24 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0824818 0.00825011 1.855091e-23 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0817951 0.00822891 3.3023790000000005e-23 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0816921 0.00824553 4.5655120000000006e-23 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0810259 0.00822942 8.403751e-23 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0807668 0.0082296 1.1487260000000001e-22 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0797666 0.00823026 3.8046660000000003e-22 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0797299 0.00823029 3.974472e-22 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0787919 0.0082309 1.204849e-21 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island - - 2.7500000000000003e-21 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0764322 0.00823242 1.8521519999999998e-20 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.077021 0.00834048 2.9417529999999997e-20 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0787127 0.00852371 2.943199e-20 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0757269 0.00823286 4.125131e-20 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0756557 0.00823291 4.4704039999999995e-20 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.06683 0.00658 1.1e-19 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0744372 0.00823367 1.7502489999999998e-19 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0743376 0.00823373 1.9550029999999998e-19 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0739447 0.00823397 3.020011e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0723327 0.00823494 1.75575e-18 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.07187 0.00823522 2.889465e-18 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0717292 0.0082353 3.3605900000000003e-18 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.343371 0.03998 9.544782e-18 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0732376 0.00853293 1.016679e-17 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0709346 0.00837993 2.8061040000000004e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.334641 0.0397257 3.927818e-17 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0693069 0.00823672 4.310844e-17 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.00101324 0.00011859 4.51e-17 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0692429 0.00823675 4.606559e-17 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0691603 0.0082368 5.017172e-17 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0687698 0.00823702 7.503054000000001e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0687643 0.00823703 7.545596000000001e-17 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0683847 0.00823724 1.113431e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0683272 0.00823728 1.1808e-16 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0680628 0.00823742 1.545934e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore - - 2.04e-16 - 26857698_primary_sjogrens_syndrome_whole_blood Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02693857 chr5:176738937 5 176738937 MXD3 Island 0.00045 0.000055 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0754268 0.0092457 3.679897e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0669618 0.00823804 4.696873e-16 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0668035 0.00823813 5.502221e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island 0.00053 0.000065 6.7e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -4.6 0.567 7.2e-16 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0656426 0.00823876 0.00000000000000173717 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17466946 chr5:176739371 5 176739371 MXD3 Island -0.000056 0.0000071 0.000000000000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04708888 chr5:176739561 5 176739561 MXD3 Island 0.00033 0.000042 0.0000000000000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.296702 0.0376092 0.000000000000003225276 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0649379 0.00823914 0.000000000000003457588 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0647489 0.00823925 0.000000000000004153268 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0643397 0.00823946 0.000000000000006166786 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0643382 0.00823947 0.000000000000006175249 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0643009 0.00823948 0.000000000000006400943 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0639308 0.00823968 0.00000000000000913022 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.290317 0.0375259 0.00000000000001078361 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0637542 0.00823977 0.00000000000001080863 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0643962 0.00842475 0.00000000000002241453 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0650131 0.00851281 0.00000000000002358828 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0628062 0.00824027 0.00000000000002653348 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0627658 0.00824029 0.00000000000002755916 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0624579 0.00824045 0.00000000000003678318 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0624456 0.00824046 0.0000000000000372078 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0643668 0.00849482 0.00000000000003742388 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0624171 0.00824047 0.00000000000003821289 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.05 0.00666 0.000000000000044 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0619481 0.00824071 0.00000000000005913949 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0618958 0.00824074 0.00000000000006207918 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0618146 0.00824078 0.00000000000006693121 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0633439 0.00844679 0.00000000000006790334 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0686178 0.00918843 0.00000000000008610962 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0627645 0.00842786 0.0000000000001005977 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0613518 0.00824102 0.0000000000001025734 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0608438 0.00824127 0.0000000000001633136 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg25101061 chr5:176739547 5 176739547 MXD3 Island 2.079424 0.2825 0.000000000000184 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0012 0.00016 0.00000000000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0602714 0.00824156 0.0000000000002745399 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0600884 0.00824165 0.0000000000003238292 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0597258 0.00824183 0.0000000000004484504 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.103423 0.0142729 0.000000000000450257 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0597188 0.00824184 0.0000000000004512762 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0596563 0.00824187 0.0000000000004772318 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0617763 0.00853577 0.0000000000004802434 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0594827 0.00824195 0.0000000000005572574 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0661006 0.00917586 0.000000000000614369 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0842911 0.0117658 0.0000000000008202684 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0662861 0.0093086 0.000000000001121745 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0844222 0.0118645 0.000000000001166598 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0585208 0.00824242 0.000000000001305273 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0584384 0.00824246 0.000000000001403199 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0998742 0.0140878 0.000000000001408136 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.058334 0.00824251 0.000000000001537522 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.083 0.01169 0.0000000000016 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0582963 0.00828826 0.000000000002101875 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0601487 0.00859301 0.000000000002675928 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0944878 0.0135873 0.000000000003697672 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0590715 0.00851999 0.000000000004283715 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0568246 0.00824323 0.000000000005666226 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -1.7 0.244 0.0000000000058 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0566537 0.00824331 0.000000000006554567 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0561763 0.00824353 0.000000000009822086 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0798552 0.011761 0.00000000001165649 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0953529 0.0140765 0.00000000001301279 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0573877 0.00853749 0.00000000001860491 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.00121858 0.00017966 0.0000000000195 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0552159 0.00824398 0.00000000002193892 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0550361 0.00824406 0.00000000002546209 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0549869 0.00824408 0.0000000000265204 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.042 0.00636 0.000000000027 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0937311 0.0140611 0.00000000002722888 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.12 0.01826 0.000000000035 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0546211 0.00824425 0.00000000003584774 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.089633 0.0135844 0.00000000004302914 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0566847 0.00860202 0.00000000004557725 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0541659 0.00824445 0.00000000005201898 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0540522 0.0082445 0.00000000005705879 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0540515 0.0082445 0.00000000005709351 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0536223 0.00824469 0.00000000008082316 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0532046 0.00824488 0.0000000001130631 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.075168 0.0116557 0.0000000001161047 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0531298 0.00824491 0.0000000001200375 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.054881 0.00854567 0.0000000001385617 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0528389 0.00824504 0.0000000001513709 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0527135 0.00824509 0.000000000167236 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0524835 0.00824519 0.0000000002006397 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.052384 0.00824524 0.0000000002170371 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg21492394 chr5:176739783 5 176739783 MXD3 South shore 0.174303 0.0274886 0.0000000002337843 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Current vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 1851 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.11 0.0174 0.00000000024 None 31552803_Dugue-PA_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0542606 0.00859286 0.000000000278635 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.00631 0.001 0.00000000033 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0517151 0.00824552 0.0000000003666636 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.065 0.01041 0.00000000038 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0533801 0.00852403 0.0000000003898957 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0515688 0.00824559 0.0000000004108686 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.02896 0.0044 0.00000000043 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0513639 0.00824567 0.0000000004816322 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.00495 0.0008 0.0000000005 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg02693857 chr5:176738937 5 176738937 MXD3 Island 0.00739 0.0012 0.000000000508 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0512448 0.00824572 0.0000000005280785 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0509832 0.00824583 0.0000000006459901 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0527719 0.00854611 0.0000000006792501 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0508964 0.00824587 0.0000000006905275 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0521723 0.00851876 0.0000000009334813 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -1.7 0.271 0.0000000011 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0502314 0.00824615 0.000000001146541 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.00119534 0.00019495 0.00000000122 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore None None 0.0000000013 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0499924 0.00824625 0.000000001373599 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0492271 0.00824656 0.000000002436029 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09564133 chr5:176738847 5 176738847 MXD3 Island 0.00046 0.000078 0.0000000026 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0566666 0.0095248 0.000000002753149 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.048991 0.00824666 0.000000002902194 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0489828 0.00824666 0.000000002919879 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0489475 0.00824667 0.000000002996896 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0489183 0.00824669 0.000000003062417 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0488434 0.00824672 0.000000003236535 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0487705 0.00824675 0.000000003415122 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0486469 0.0082468 0.000000003740307 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Sun D Bogalusa Heart Study, Georgia Stress and Heart Study 31510868 2019-09-12 body mass index EFO_0004340 meta-analysis in Europeans Online Table I DNA methylation body mass index age, sex, smoking, cell composition (reference based), batch effects Beta Values kg/m2 Illumina HumanMethylation450 Whole blood None 1247 2 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.00093 None 0.0000000043 None 31510868_Sun-D_body_mass_index_meta-analysis_in_europeans Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08076617 chr5:176739172 5 176739172 MXD3 Island 0.00026 None 0.0000000044 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0840692 0.0143439 0.000000004699944 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.053924 0.00924293 0.000000005522745 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0481064 0.00824701 0.00000000555206 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0498952 0.00857938 0.000000006163353 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0479501 0.00824707 0.000000006219529 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0822533 0.0141685 0.0000000065558 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0824242 0.0142137 0.000000006811416 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0494737 0.00854099 0.000000007076495 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0494608 0.00854818 0.000000007350144 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0477042 0.00824717 0.000000007429513 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0548056 0.00950556 0.000000008298968 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg09564133 chr5:176738847 5 176738847 MXD3 Island -0.01346 0.0023 0.00000000959 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0489649 0.00855186 0.00000001050605 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0466974 0.00824756 0.00000001524598 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0798187 0.014119 0.00000001603313 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0465083 0.00824764 0.0000000174205 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0771409 0.0137088 0.00000001866142 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.075638 0.0134662 0.00000001979777 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 CD4+ T-cells Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 CD4+ T-cells - 60 1 46.5 Males European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.337272 0.0602 0.0000000206 None 27105112_hiv_infection_cd4_tcells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0461811 0.00824776 0.00000002191695 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0461737 0.00824777 0.00000002203042 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0460955 0.0082478 0.00000002326748 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0460785 0.0082478 0.00000002354613 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0475987 0.00852759 0.00000002423526 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -2 0.355 0.000000025 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg11461836 chr5:176739316 5 176739316 MXD3 Island 0.00551 0.001 0.0000000251 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0458394 0.00824789 0.00000002781016 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.052683 0.0095019 0.00000002999482 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.213519 0.0386298 0.00000003296081 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0094 0.0017 0.000000034 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0769396 0.0139558 0.00000003585084 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.00488 0.00089 0.000000036 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Ligthart S CHARGE 27955697 2016-12-12 C-reactive protein EFO_0004458 Discovery Table S3 DNA methylation C-reactive protein Age, sex, smoking, body mass index, cell counts and technical covariates Beta values mg/l Illumina HumanMethylation450 Whole blood C-reactive protein levels were log-transformed 8863 9 65 Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0033 6e-04 0.0000000389 - 27955697_creactive_protein_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0452743 0.00824811 0.00000004108102 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.00066694 0.00012073 0.0000000416 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0452117 0.00824813 0.00000004288231 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0450314 0.0082482 0.00000004851192 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0450051 0.00824821 0.00000004938931 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09044296 chr5:176739296 5 176739296 MXD3 Island -0.00051 0.000094 0.000000052 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0449156 0.00824824 0.00000005249678 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0448944 0.00824825 0.00000005326118 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0445921 0.00824836 0.00000006538868 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0049 9e-04 0.000000066 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0768826 0.0142317 0.00000006684936 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0454935 0.00842349 0.00000006738118 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.214767 0.0398862 0.00000007360096 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0511156 0.00949382 0.00000007393524 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0442168 0.0082485 0.00000008420714 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0441728 0.00824851 0.00000008673006 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.045726 0.00855252 0.0000000910166 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.314864 0.0589417 0.00000009305195 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0636216 0.0119306 0.0000000982312 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0727527 0.0136668 0.0000001034 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0457747 0.0086012 0.0000001041999 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0438778 0.00824862 0.0000001056348 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.043813 0.00824864 0.0000001102923 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0571485 0.010808 0.0000001256883 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10533277 chr5:176739312 5 176739312 MXD3 Island -0.000088 0.000017 0.00000015 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0433015 0.00824883 0.0000001547082 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0432543 0.00824884 0.0000001595906 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.065 0.01234 0.00000016 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Fully-adjusted_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16616449 chr5:176739309 5 176739309 MXD3 Island -0.000077 0.000015 0.00000022 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0442641 0.00853999 0.0000002210614 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0440588 0.00857592 0.0000002819925 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0421645 0.00824923 0.0000003239172 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0601698 0.0117989 0.0000003446085 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0603228 0.0118368 0.0000003507999 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0419882 0.00824929 0.0000003626467 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0418463 0.00824934 0.0000003970197 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0417837 0.00824936 0.0000004131893 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0699577 0.0138376 0.0000004341324 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0414354 0.00824948 0.0000005152405 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13278795 chr5:176738672 5 176738672 MXD3 Island 0.0021 0.00042 0.00000052 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.00069704 0.00013809 0.000000525 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0413142 0.00824952 0.0000005561704 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0309 0.0062 0.00000058 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0424603 0.00855106 0.0000006929505 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0675949 0.0136276 0.0000007123471 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Sun D Bogalusa Heart Study 31510868 2019-09-12 body mass index EFO_0004340 Discovery in Europeans Online Table I DNA methylation body mass index age, sex, smoking, cell composition (reference based), batch effects Beta Values kg/m2 Illumina HumanMethylation450 Whole blood None 995 1 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.00099 None 0.00000074 None 31510868_Sun-D_body_mass_index_discovery_in_europeans Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0408547 0.00824968 0.0000007416396 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0066 0.0013 0.00000075 - 27651444_smoking_current_vs_never_smoking Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg25101061 chr5:176739547 5 176739547 MXD3 Island 0.18808 0.0381 0.000000796 - 27105112_hiv_infection_neutrophils Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island 0.0021 0.00043 0.0000008 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0529513 0.0107258 0.0000008027608 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0406746 0.00824974 0.0000008295399 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0785054 0.0159695 0.0000008931177 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0405362 0.00824979 0.0000009038106 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0705281 0.0143706 0.0000009309226 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0404747 0.00824981 0.0000009388204 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0460271 0.00939094 0.0000009626227 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0153 0.0031 0.000001 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0417251 0.00853771 0.00000103388 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0403106 0.00824986 0.000001038756 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island 0.0401216 0.00824992 0.000001166631 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0400943 0.00824993 0.000001186267 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0071 0.0015 0.0000012 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0400373 0.00824995 0.000001228349 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0399851 0.00824997 0.000001268206 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0399344 0.00824999 0.000001308054 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0562371 0.0116477 0.000001391944 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0396468 0.00825008 0.000001557985 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0395794 0.0082501 0.000001622814 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.040654 0.00848988 0.000001696587 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08076617 chr5:176739172 5 176739172 MXD3 Island 0.00082 None 0.0000019 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0515387 0.0108215 0.0000019294 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.062 0.0131 0.000002 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0552597 0.0116512 0.000002127301 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0513664 0.0108334 0.000002141445 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0404095 0.00852568 0.000002160098 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg09564133 chr5:176738847 5 176738847 MXD3 Island 0.135642 0.0286336 0.000002183759 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11461836 chr5:176739316 5 176739316 MXD3 Island -0.000077 0.000016 0.0000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0389582 0.0082503 0.00000235658 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0388116 0.00825035 0.00000257136 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0386782 0.00825039 0.000002783186 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0442851 0.00944912 0.000002801548 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.01938 0.00402 0.0000029 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0641877 0.0137364 0.000002997502 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16616449 chr5:176739309 5 176739309 MXD3 Island 0.00566 0.00118 0.000003 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0559535 0.0119852 0.000003060193 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0539632 0.0115629 0.000003084333 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.044222 0.00947824 0.000003103917 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.038448 0.00825047 0.000003188404 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.038425 0.00825047 0.000003231793 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0538753 0.0115889 0.00000336656 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0382676 0.00825052 0.000003544809 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0324 0.007 0.0000036 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Marzi C - 27824951 2016-11-08 C-reactive protein EFO_0004458 KORA F4 discovery Table SB C-reactive protein DNA methylation Age, sex, smoking, body mass index, fasting status, cell counts and technical covariates mg/l Beta values Illumina HumanMethylation450 Peripheral blood - 1741 1 60.9 Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.017 0.004 0.00000361 - 27824951_creactive_protein_kora_f4_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0381959 0.00825055 0.000003697039 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0640862 0.0138432 0.000003698207 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0380531 0.00825059 0.000004018622 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0551419 0.011989 0.000004273242 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0121 0.0026 0.0000043 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0379005 0.00825064 0.000004392096 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21492394 chr5:176739783 5 176739783 MXD3 South shore -0.130078 0.0283544 0.00000451594 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0393337 0.0085746 0.000004528819 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0378373 0.00825066 0.000004556109 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0036 0.00075 0.0000047 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0376867 0.00825071 0.000004971407 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0376496 0.00825072 0.000005079077 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0375 0.00825076 0.000005536678 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0374681 0.00825077 0.000005639171 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0374501 0.00825078 0.000005697759 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0373847 0.0082508 0.00000591581 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.199014 0.0439518 0.000005993837 None 39706196_Hannah-M.-Smith_bmi_sensitivity Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0406 0.009 0.0000061 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore 0.0817143 0.0180798 0.000006233427 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.043022 0.00952722 0.00000636038 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q16610 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q16610 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0372337 0.00825085 0.000006450179 Q16610 41361833_Josephine_Robertson_Q16610_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Stroke (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Stroke (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18056 1 Adults (18-65y) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.056 0.01236 0.0000067 None Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0370678 0.0082509 0.000007090517 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0370602 0.0082509 0.000007121075 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0385005 0.00857227 0.000007133613 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09564133 chr5:176738847 5 176738847 MXD3 Island 0.0023 0.00051 0.0000072 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0370004 0.00825092 0.000007367603 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0537356 0.0120026 0.00000762785 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.270642 0.0605386 0.00000785058 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0730024 0.016336 0.000007924562 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13278795 chr5:176738672 5 176738672 MXD3 Island 0.142455 0.0318809 0.000007930525 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0374379 0.00838031 0.000007977911 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore None None 0.0000087 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0366686 0.00825102 0.000008889353 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02693857 chr5:176738937 5 176738937 MXD3 Island 0.0016 0.00036 0.0000089 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08076617 chr5:176739172 5 176739172 MXD3 Island 0.00017 0.000038 0.000009 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0246 0.0055 0.000009 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0421752 0.00952548 0.000009596922 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25101061 chr5:176739547 5 176739547 MXD3 Island 0.00748 0.00165 0.0000097 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.037895 0.00857001 0.000009857862 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0612331 0.0138496 0.000009881585 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0364637 0.00825108 0.000009974831 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0375527 0.00852175 0.00001057091 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21492394 chr5:176739783 5 176739783 MXD3 South shore -0.125129 0.0284207 0.00001075357 None 39706196_Hannah-M.-Smith_body_fat_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -1.4 0.316 0.000011 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0362655 0.00825114 0.00001114417 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0516744 0.0117582 0.00001116834 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0362366 0.00825115 0.00001132561 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0374923 0.00854326 0.00001149222 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0362323 0.00825811 0.00001154723 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0627661 0.0143133 0.00001167024 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg10533277 chr5:176739312 5 176739312 MXD3 Island -1.01473 0.2317 0.0000119 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.052212 0.0119202 0.00001194289 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0360758 0.0082512 0.00001238525 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0885219 0.0203296 0.00001343798 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0391342 0.00902446 0.00001457658 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00318495 chr5:176739903 5 176739903 MXD3 South shore 0.0815174 0.0188155 0.0000148241 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0596243 0.0137687 0.000014981 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.00412 0.00095 0.000015 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0356686 0.00825132 0.00001550947 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0356531 0.00825132 0.00001564163 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0369373 0.00855169 0.00001575538 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island 0.142076 0.032914 0.00001593079 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Geurtsen ML Generation R 31892367 2019-12-31 Liver fat CMO_0002187 Basic model Table S8 Liver fat DNA methylation Gestational age, sex, cell composition (reference based), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 344 1 Children Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.25 0.06 0.000016 None 31892367_Geurtsen-ML_liver_fat_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0406643 0.00942704 0.00001616812 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.036943 0.0085823 0.0000168408 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0593842 0.0138407 0.00001793751 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_2 Geurtsen ML Generation R 31892367 2019-12-31 Liver fat CMO_0002187 Child BMI model Table S8 Liver fat DNA methylation Gestational age, sex, cell composition (reference based), batch effects, maternal age, education level, early-pregnancy body mass index, smoking, childhood body mass index at 10 None Beta Values Illumina HumanMethylation450 Whole blood None 344 1 Children Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.25 0.06 0.000019 None 31892367_Geurtsen-ML_liver_fat_child_bmi_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.014 0.00323 0.000019 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0610526 0.0143299 0.00002052311 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.001 0.00024 0.000021 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0459272 0.0108108 0.00002167536 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.255898 0.0604951 0.00002348406 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25101061 chr5:176739547 5 176739547 MXD3 Island 0.0348843 0.00825155 0.00002376209 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0348749 0.00825155 0.00002388253 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.00081 0.00019 0.000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0359756 0.00852008 0.00002431195 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Stroke (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Stroke (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18056 1 Adults (18-65y) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.069 0.01649 0.000026 None Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0347042 0.0082516 0.00002617547 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P13671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P13671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0346236 0.00825162 0.00002732935 P13671 41361833_Josephine_Robertson_P13671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0345361 0.00825165 0.00002863798 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0345328 0.00825165 0.00002868773 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0501934 0.0120051 0.00002919227 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25101061 chr5:176739547 5 176739547 MXD3 Island 0.0344327 0.00825168 0.00003026025 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0775789 0.0186026 0.00003056589 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0344123 0.00825168 0.00003058909 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0446678 0.0107135 0.0000307272 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P13671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P13671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore -0.0343624 0.0082517 0.00003141113 P13671 41361833_Josephine_Robertson_P13671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0450187 0.0108235 0.00003209755 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0357625 0.00860986 0.00003290421 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0354698 0.00855215 0.00003380556 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0341384 0.00825176 0.0000353683 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Battram T GEO 27886173 2020-09-15 Ulcerative colitis EFO_0000729 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Ulcerative colitis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 163 1 Adults Both European cg11461836 chr5:176739316 5 176739316 MXD3 Island 0.0041 0.00097 0.000036 None 27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0340659 0.00825178 0.000036746 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore None None 0.000037 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q16610 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q16610 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0352694 0.00855771 0.0000378711 Q16610 41361833_Josephine_Robertson_Q16610_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P69905 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P69905 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0339986 0.0082518 0.0000380717 P69905 41361833_Josephine_Robertson_P69905_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0433402 0.0105209 0.00003818835 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore 0.0586017 0.0143371 0.00004385387 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q16610 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q16610 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0336087 0.00825191 0.00004668697 Q16610 41361833_Josephine_Robertson_Q16610_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04708888 chr5:176739561 5 176739561 MXD3 Island 0.0012 0.00028 0.000047 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0756457 0.0186457 0.00004992516 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island 0.0334003 0.00825196 0.00005202067 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q16610 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q16610 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0333248 0.00825199 0.00005409072 Q16610 41361833_Josephine_Robertson_Q16610_OSCA_model_1 Nicodemus-Johnson J - 28708104 2017-07-14 Juice consumption - - Table S5 DNA methylation Juice consumption Technical covariates M values - Illumina HumanMethylation450 Peripheral blood - 2148 1 65 Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island -0.00013991 3.46e-05 0.0000541 - 28708104_juice_consumption Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.06 0.01487 0.000056 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg16616449 chr5:176739309 5 176739309 MXD3 Island -0.878738 0.2185 0.0000578 - 27105112_hiv_infection_discovery Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.8 0.2 0.00006 4807 31197173_Liu-J_fasting_glucose_base Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0054 0.0013 0.000062 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0341185 0.00855206 0.00006653426 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0328817 0.00825211 0.00006790802 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore None None 0.00007 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.153422 0.0386463 0.00007219107 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.032744 0.00825214 0.00007284305 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis adjusted model Table S2 DNA methylation Hypertensive disorders of pregnancy Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0094 0.0024 0.000074 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04586126 chr5:176734633 5 176734633 MXD3 Island -0.0636759 0.0160742 0.00007487044 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0567684 0.0143393 0.00007563975 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01203960 chr5:176735073 5 176735073 MXD3 South shore 0.0470413 0.0118962 0.00007711437 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0325978 0.00825218 0.00007845121 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.0325779 0.00825219 0.00007924519 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island 0.0325391 0.0082522 0.00008081476 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg26087598 chr5:176739400 5 176739400 MXD3 Island -0.83 0.211 0.000082 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.0565321 0.0143511 0.00008212525 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01009 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01009 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25213720 chr5:176734343 5 176734343 MXD3 North shore -0.032477 0.00825222 0.00008339074 P01009 41361833_Josephine_Robertson_P01009_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02824710 chr5:176739926 5 176739926 MXD3 South shore -0.0324438 0.00825222 0.0000847969 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.033 0.00849 0.000085 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07671752 chr5:176734858 5 176734858 MXD3 Island -0.0322908 0.00825227 0.00009158459 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0334567 0.00856038 0.00009335573 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0333661 0.0085412 0.00009406929 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island 0.0322369 0.00825228 0.00009409119 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg25368647 chr5:176736591 5 176736591 MXD3 North shore -0.0034 0.00085 0.000095 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25368647 chr5:176736591 5 176736591 MXD3 North shore 0.0335599 0.00861053 0.00009760783 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18465082 chr5:176734745 5 176734745 MXD3 Island -0.032129 0.00825231 0.00009931512 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1