author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01482279 chr17:38083788 17 38083788 ORMDL3 Island 0.0005 0.000057 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.0055 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore 0.017 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0047 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore 0.015 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore -0.0036 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore 0.013 0.0015 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0036 0.00012 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16638648 chr17:38083781 17 38083781 ORMDL3 Island -0.000078 0.0000083 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf None None 4.2e-154 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore 0.47826 0.0072 6.2e-135 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore 0.32945 0.00571 1.3000000000000001e-123 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.23526 0.00434 8.9e-119 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore 0.3198 0.00598 1e-117 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore 0.11731 0.00323 3.5e-88 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf None None 5.6e-87 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755934__gene_symbol__ormdl3__meta-analysis Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore - - 2.23e-82 - 28056824_age_4_vs_age_0 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf None None 2.7e-81 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore - - 2.1400000000000003e-79 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.25976 0.00861 5.7e-75 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.146165 0.0081679 7.297199e-71 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore None None 4e-68 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore -0.25478 0.00952 7.6e-67 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.130165 0.00818633 1.8677229999999998e-56 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.126869 0.00818985 1.062019e-53 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea None None 8e-53 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.123191 0.00819368 1.03446e-50 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.121211 0.00819569 3.864042e-49 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 2.03835 0.06828 1.72e-47 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.116551 0.0082003 1.525745e-45 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore - - 1.16e-44 - 28056824_age_4_vs_age_0 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 1.60339 0.06708 5.35e-40 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 2.4917 0.10588 1.73e-39 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore 2.05899 0.10972 2.46e-32 - 25282492_fetal_vs_adult_liver Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf - - 3.21e-32 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0898609 0.00822317 1.085693e-27 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea - - 1.0999999999999999e-25 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26971420 chr17:38085230 17 38085230 ORMDL3 South shore 0.02312 0.00194 5.6999999999999995e-25 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0822371 0.0082286 1.923181e-23 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0770984 0.008232 8.634033e-21 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0760531 0.00823266 2.850718e-20 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0750238 0.0082333 9.098115e-20 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore None None 5.7e-19 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0730164 0.00823453 8.360619e-19 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg26971420 chr17:38085230 17 38085230 ORMDL3 South shore - - 8.95e-19 - 24500968_pancreatic_ductal_adenocarcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0724467 0.00823488 1.552279e-18 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0718557 0.00823523 2.934156e-18 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0712055 0.00823561 5.8773360000000004e-18 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf None None 1.8e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755934__gene_symbol__ormdl3__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09155575 chr17:38084037 17 38084037 ORMDL3 Island 0.0013 None 2.6e-17 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore None None 4e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755934__gene_symbol__ormdl3__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0679919 0.00823746 1.661507e-16 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0671068 0.00823796 4.061512e-16 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02305874 chr17:38083354 17 38083354 ORMDL3 Island 0.0005 0.000061 4.4e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13476672 chr17:38083406 17 38083406 ORMDL3 Island -0.00009 0.000011 6.7e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14647739 chr17:38084012 17 38084012 ORMDL3 Island 0.00061 0.000078 0.0000000000000038 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea None None 0.0000000000000041 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755934__gene_symbol__ormdl3__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0063 0.00081 0.0000000000000091 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.062997 0.00824017 0.00000000000002216843 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0625107 0.00824042 0.00000000000003500954 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0624347 0.00824046 0.00000000000003758913 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.236999 0.0314844 0.00000000000005412974 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0620119 0.00824068 0.00000000000005573945 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0618129 0.00824078 0.0000000000000670369 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0613207 0.00824103 0.0000000000001055483 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0607149 0.00824134 0.0000000000001836495 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0606415 0.00824138 0.0000000000001963337 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0601469 0.00824162 0.0000000000003071932 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05271360 chr17:38083955 17 38083955 ORMDL3 Island -0.000069 0.0000096 0.0000000000005 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.00075071 0.00010349 0.000000000000779 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.058694 0.00824234 0.000000000001120975 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0585503 0.00824241 0.000000000001271914 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0726121 0.0102371 0.000000000001371747 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 2.4 0.339 0.0000000000023 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.369479 0.0530623 0.000000000003447994 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0570655 0.00824312 0.000000000004611582 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.257329 0.037572 0.00000000000767722 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0563976 0.00824343 0.000000000008146321 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0562977 0.00824348 0.000000000008864434 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.055678 0.00824376 0.00000000001492854 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.357259 0.0530257 0.00000000001662456 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.176499 0.0266207 0.00000000003452698 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0545466 0.00824428 0.00000000003810836 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0053 0.00073 0.000000000058 None 33564054_Kashima-K_gestational_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.348106 0.0531925 0.00000000006146158 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0657993 0.0100567 0.00000000006237496 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore None None 0.00000000011 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0532234 0.00824487 0.0000000001113745 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore 0.1537979 0.0238606 0.0000000001151 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.037 0.00571 0.00000000012 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0531043 0.00824492 0.0000000001225053 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0529688 0.00824498 0.0000000001364968 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0644643 0.0100671 0.0000000001565264 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0526489 0.00824512 0.0000000001760216 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0636353 0.00997562 0.0000000001834895 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0519668 0.00824542 0.0000000003012397 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.051851 0.00824547 0.0000000003297808 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0516002 0.00824557 0.0000000004009579 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0510004 0.00824583 0.000000000637533 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore -0.0560213 0.00908007 0.0000000007022115 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0601908 0.00980812 0.0000000008635175 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0505355 0.00824602 0.0000000009100104 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0632124 0.0103356 0.0000000009839544 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore -0.02 0.0033 0.0000000014 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0495175 0.00824644 0.00000000196198 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0490356 0.00824664 0.000000002807987 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3755862 (gene symbol: IKZF3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3755862 (gene symbol: IKZF3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore None None 0.0000000031 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3755862__gene_symbol__ikzf3__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.0487791 0.00824674 0.00000000339363 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0580824 0.010003 0.000000006510529 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09155575 chr17:38084037 17 38084037 ORMDL3 Island 0.0037 None 0.0000000083 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0474613 0.00824727 0.000000008848406 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore -0.0519024 0.00902351 0.000000009000054 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0802414 0.0140157 0.00000001053842 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore 0.115882 0.0202705 0.00000001086 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0471288 0.0082474 0.00000001122401 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0469949 0.00824745 0.00000001234694 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg09155575 chr17:38084037 17 38084037 ORMDL3 Island 0.02864 0.005 0.0000000136 - 23334450_rheumatoid_arthritis Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg16638648 chr17:38083781 17 38083781 ORMDL3 Island 0.00434 8e-04 0.00000002 - 23334450_rheumatoid_arthritis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.289354 0.0517547 0.00000002291664 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg26971420 chr17:38085230 17 38085230 ORMDL3 South shore -0.01306 0.0023 0.0000000255 - 23334450_rheumatoid_arthritis Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -1.7 0.3 0.000000027 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04145193 chr17:38083691 17 38083691 ORMDL3 Island 0.0004 None 0.000000029 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0559117 0.010159 0.00000003782281 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.146385 0.0266105 0.00000003829254 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0453064 0.00824809 0.00000004018302 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0560228 0.0102597 0.00000004825474 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.01193 0.00219 0.00000005 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04145193 chr17:38083691 17 38083691 ORMDL3 Island -0.00032 0.000059 0.000000054 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14647739 chr17:38084012 17 38084012 ORMDL3 Island 0.00051 None 0.00000006 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.00099 0.00018 0.000000068 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02305874 chr17:38083354 17 38083354 ORMDL3 Island 0.0444328 0.00824842 0.00000007281729 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04145193 chr17:38083691 17 38083691 ORMDL3 Island 0.0444278 0.00824842 0.00000007306281 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0555639 0.010321 0.00000007414149 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea None None 0.00000008 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.04428 0.00824847 0.00000008070724 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0457183 0.00861041 0.0000001114397 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.0437749 0.00824866 0.0000001131238 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0436433 0.0082487 0.0000001234493 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.043544 0.00824874 0.000000131842 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02305874 chr17:38083354 17 38083354 ORMDL3 Island 0.0021 0.0004 0.00000014 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.140442 0.0266942 0.0000001448646 None 39706196_Hannah-M.-Smith_body_fat_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.029 0.0056 0.00000015 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.0431442 0.00824888 0.0000001715594 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0525193 0.0100547 0.0000001781149 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01482279 chr17:38083788 17 38083788 ORMDL3 Island 0.00717 0.00135 0.00000029 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.051961 0.0101548 0.000000314567 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0420982 0.00824925 0.0000003380057 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0420515 0.00824927 0.0000003482683 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.04196 0.0082493 0.0000003692366 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02305874 chr17:38083354 17 38083354 ORMDL3 Island 0.00665 0.00126 0.00000039 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0436202 0.00865414 0.0000004701419 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.163435 0.0325155 0.000000504545 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0414442 0.00824948 0.0000005123947 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Madden RA Generation Scotland 33079621 2020-10-20 birthweight EFO_0004344 birthweight set 2 https://doi.org/10.7488/ds/2876, ST2, ST3 DNA methylation birthweight sex, gestational age, cell composition (reference based), epigenetic PCs, smoking, age Beta Values g Illumina HumanMethylationEPIC Whole blood None 362 1 Adults Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore 0.081 0.0158 0.00000054 Beta is logFC 33079621_Madden-RA_birthweight_birthweight_set_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.13177 0.026344 0.0000005732833 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.041262 0.00824954 0.0000005747256 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0412598 0.00824954 0.0000005755397 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.00040454 8.06e-05 0.000000609 - 27717397_gestational_age_ultrasoundestimated_gestational_age Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore None None 0.00000063 None 34584077_Jenny-van-Dongen_monozygotic_twinning Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.0410443 0.00824961 0.000000658834 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0420862 0.00848505 0.0000007126513 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0408754 0.00824967 0.0000007321652 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.123593 0.024982 0.0000007596447 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.129426 0.0262844 0.0000008555326 None 39706196_Hannah-M.-Smith_bmi_discovery Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.0119 0.0024 0.00000086 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0406142 0.00824976 0.0000008611962 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04145193 chr17:38083691 17 38083691 ORMDL3 Island 0.0147 0.00289 0.00000089 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14647739 chr17:38084012 17 38084012 ORMDL3 Island 0.00795 0.00157 0.00000089 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01482279 chr17:38083788 17 38083788 ORMDL3 Island 0.0018 0.00037 0.0000009 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.001 None 0.00000096 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04409495 chr17:38083144 17 38083144 ORMDL3 North shore -0.0408957 0.00837175 0.000001045411 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0401984 0.0082499 0.000001112966 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.050119 0.0103324 0.000001243204 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0400051 0.00824996 0.000001252787 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea - - 0.00000131 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore -0.0399177 0.00824999 0.000001321395 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.119734 0.024926 0.000001571554 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02305874 chr17:38083354 17 38083354 ORMDL3 Island 0.039525 0.00825012 0.000001677096 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0655695 0.0137329 0.000001817843 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.00011794 2.47e-05 0.00000187 - 27843151_alcohol_consumption_per_day_european_ancestry Gadd DA Generation Scotland 35945220 31/07/2022 OLFM1 protein levels (SeqId = 5703-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OLFM1 protein levels (SeqId = 5703-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Noelin 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.758 0.159 0.000002 None Gadd-DA_olfm1_protein_levels__seqid___5703-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0460909 0.00969446 0.000002009714 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0390055 0.00825029 0.000002291049 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.022 0.00455 0.0000023 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0389455 0.00825031 0.000002374484 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.0403701 0.00855597 0.000002399575 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0469155 0.00995018 0.000002438914 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0704751 0.0149797 0.000002565512 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island -0.000093 0.00002 0.0000026 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore None None 0.0000035 None 34584077_Jenny-van-Dongen_monozygotic_twinning Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.00263 0.00057 0.0000035 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0381509 0.00825056 0.000003795541 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.92 0.199 0.0000041 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island 0.00595 0.00126 0.0000045 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0378353 0.00825066 0.000004561329 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0378108 0.00825067 0.000004626723 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04409495 chr17:38083144 17 38083144 ORMDL3 North shore -0.0384739 0.00843012 0.000005062943 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0376406 0.00825072 0.000005105422 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0376071 0.00825073 0.000005205194 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0255 0.00547 0.0000058 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.0422197 0.00932289 0.000005984269 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf -0.00062 0.00014 0.0000063 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0448875 0.00994267 0.000006391982 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0463657 0.0102934 0.000006707603 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CISD2 protein levels (SeqId = 8094-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CISD2 protein levels (SeqId = 8094-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CDGSH iron-sulfur domain-containing protein 2 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.715 0.159 0.000007 None Gadd-DA_cisd2_protein_levels__seqid___8094-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23202472 chr17:38083134 17 38083134 ORMDL3 North shore 0.0377211 0.00843239 0.000007758073 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0368893 0.00825095 0.000007846861 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.0042 0.00095 0.0000087 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0366208 0.00825103 0.000009132311 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore -0.0374225 0.00844318 0.000009391948 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.0365662 0.00825105 0.000009416948 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0455729 0.0102971 0.000009677294 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Madden RA Generation Scotland 33079621 2020-10-20 birthweight EFO_0004344 birthweight set 2 https://doi.org/10.7488/ds/2876, ST2, ST3 DNA methylation birthweight sex, gestational age, cell composition (reference based), epigenetic PCs, smoking, age Beta Values g Illumina HumanMethylationEPIC Whole blood None 362 1 Adults Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore 0.055 0.0121 0.0000097 Beta is logFC 33079621_Madden-RA_birthweight_birthweight_set_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea None None 0.0000099 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.133397 0.0301764 0.000009903879 None 39706196_Hannah-M.-Smith_bmi_sensitivity Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.009 0.002 0.00001 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea 0.00038 0.000086 0.00001 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.009 0.002 0.0000104 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.0363706 0.00825111 0.00001050873 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0363491 0.00825112 0.00001063615 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0362196 0.00825115 0.00001143308 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.048 0.01097 0.000012 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0592786 0.0135902 0.00001298344 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 OLFM1 protein levels (SeqId = 5703-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OLFM1 protein levels (SeqId = 5703-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Noelin 774 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.584 0.134 0.000013 None Gadd-DA_olfm1_protein_levels__seqid___5703-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0359832 0.00825122 0.00001303788 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.035983 0.00825122 0.00001303971 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.035979 0.00825123 0.00001306829 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.128525 0.0295123 0.00001338455 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0431853 0.00992969 0.00001376156 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.0381199 0.00876596 0.00001379218 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea None None 0.000014 None 31789449_Dugue-P-A_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.0368736 0.00849266 0.00001422543 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0358246 0.00825127 0.00001423307 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0358164 0.00825127 0.00001429713 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0448623 0.0103452 0.00001457167 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0357573 0.00825129 0.00001477112 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island 0.867214 0.2005 0.0000153 - 27105112_hiv_infection_discovery Witt S None 32080920 02-02-2020 alcohol withdrawal recovery None discovery Table S1 DNA methylation alcohol withdrawal recovery Age, Smoking, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylationEPIC whole blood two weeks after vs active withdrawal 99 1 Adults Males European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 1.6 0.352 0.000016 None 32080920_Witt-S_alcohol_withdrawal_recovery_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.035607 0.00825134 0.00001604265 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Jonsson J Treatment of Obese Pregnant women study 33431374 2021-04-01 Physical activity and low-energy diet during pregnancy EFO_0003940, EFO_0002755 basic model with smoking adjustment Table S1 DNA methylation Physical activity and low-energy diet during pregnancy maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex, smoking M Values None Illumina HumanMethylation450 Cord blood Data comes from an RCT 208 1 Infants Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island None None 0.000017 None 33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment Battram T GEO 25282492 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE61278. Compared fetal liver tissue to adult liver tissue of different individuals None DNA methylation Age Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Fetal liver, adult liver None 110 1 Adults Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.384 0.084 0.000017 None 25282492_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.0354621 0.00825138 0.00001736799 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 0.0354422 0.00825138 0.00001755742 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0442394 0.0103168 0.0000181362 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.130142 0.0303731 0.00001839156 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0576181 0.013473 0.00001909922 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore -0.0352838 0.00825143 0.00001914154 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0357362 0.00837582 0.00001997287 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.00565 0.00133 0.00002 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23202472 chr17:38083134 17 38083134 ORMDL3 North shore 0.0357704 0.00839001 0.00002025545 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf -0.00011816 2.77e-05 0.0000204 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0351539 0.00825147 0.00002054087 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore None None 0.000023 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.022 0.00512 0.000023 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.0346504 0.00820249 0.00002410555 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04145193 chr17:38083691 17 38083691 ORMDL3 Island 0.0348228 0.00825156 0.00002456081 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Jonsson J Treatment of Obese Pregnant women study 33431374 2021-04-01 Physical activity and low-energy diet during pregnancy EFO_0003940, EFO_0002755 basic model without gestational weight gain adjustment Table S1 DNA methylation Physical activity and low-energy diet during pregnancy maternal age, maternal prepregnancy body mass index, gestational age, sex M Values None Illumina HumanMethylation450 Cord blood Data comes from an RCT 208 1 Infants Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island None None 0.000025 None 33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_without_gestational_weight_gain_adjustment Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.0347766 0.00825177 0.00002518899 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.034771 0.00825158 0.00002525503 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Jonsson J Treatment of Obese Pregnant women study 33431374 2021-04-01 Physical activity and low-energy diet during pregnancy EFO_0003940, EFO_0002755 basic model Table S1 DNA methylation Physical activity and low-energy diet during pregnancy maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex M Values None Illumina HumanMethylation450 Cord blood Data comes from an RCT 208 1 Infants Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island None None 0.000026 None 33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14647739 chr17:38084012 17 38084012 ORMDL3 Island 0.0016 None 0.000026 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0435173 0.0103573 0.00002666068 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0414797 0.00990062 0.00002810736 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Jonsson J Treatment of Obese Pregnant women study 33431374 2021-04-01 Physical activity and low-energy diet during pregnancy EFO_0003940, EFO_0002755 basic model with smoking adjustment and without gestational weight gain adjustment Table S1 DNA methylation Physical activity and low-energy diet during pregnancy maternal age, maternal prepregnancy body mass index, gestational age, sex, smoking M Values None Illumina HumanMethylation450 Cord blood Data comes from an RCT 208 1 Infants Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island None None 0.000029 None 33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment_and_without_gestational_weight_gain_adjustment Gadd DA Generation Scotland 35945220 31/07/2022 SPINK7 protein levels (SeqId = 10974-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPINK7 protein levels (SeqId = 10974-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine protease inhibitor Kazal-type 7 774 1 Adults (18-65 years) Both European cg02979140 chr17:38083125 17 38083125 ORMDL3 North shore -0.5 0.121 0.000029 None Gadd-DA_spink7_protein_levels__seqid___10974-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.0344605 0.00825167 0.00002981568 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore -0.0344378 0.00825167 0.0000301772 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0428069 0.0102871 0.0000318338 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0343368 0.0082517 0.00003184146 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Aghagoli G The Neonatal Neurobehavior and Outcomes in Very Preterm Infants 32967004 07-04-2021 cry acoustics factor 1 None None Supplementary Table 1 cry acoustics factor 1 DNA methylation Sex, PMA, recruitment site, proportions of epithelial cells None Beta values Illumina HumanMethylationEPIC Buccal None 335 1 Infants Both European cg13476672 chr17:38083406 17 38083406 ORMDL3 Island -0.002 0.001 0.000033 None 32967004_Aghagoli-G_cry_acoustics_factor_1 Gadd DA Generation Scotland 35945220 31/07/2022 GAGE2D protein levels (SeqId = 18273-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAGE2D protein levels (SeqId = 18273-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: G antigen 2D 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.659 0.159 0.000033 None Gadd-DA_gage2d_protein_levels__seqid___18273-14__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore -0.85 0.205 0.000033 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore -0.0341924 0.00825174 0.00003437333 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.123835 0.0299034 0.00003471795 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Jonsson J Treatment of Obese Pregnant women study 33431374 2021-04-01 Physical activity and low-energy diet during pregnancy EFO_0003940, EFO_0002755 adjustment only for sex and gestational age Table S1 DNA methylation Physical activity and low-energy diet during pregnancy gestational age, sex M Values None Illumina HumanMethylation450 Cord blood Data comes from an RCT 208 1 Infants Both European cg02152119 chr17:38083958 17 38083958 ORMDL3 Island None None 0.000035 None 33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_adjustment_only_for_sex_and_gestational_age Gadd DA Generation Scotland 35945220 31/07/2022 SAA4 protein levels (SeqId = 15516-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SAA4 protein levels (SeqId = 15516-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serum amyloid A-4 protein 774 1 Adults (18-65 years) Both European cg02979140 chr17:38083125 17 38083125 ORMDL3 North shore -0.498 0.12 0.000035 None Gadd-DA_saa4_protein_levels__seqid___15516-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0341559 0.00825175 0.00003504293 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0421914 0.0102161 0.00003649465 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg04308185 chr17:38084377 17 38084377 ORMDL3 South shore None None 0.000037 None 34584077_Jenny-van-Dongen_monozygotic_twinning Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore 0.0339347 0.00825182 0.00003937079 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CEBPA protein levels (SeqId = 18874-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CEBPA protein levels (SeqId = 18874-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CCAAT/enhancer-binding protein alpha 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.65 0.159 0.000041 None Gadd-DA_cebpa_protein_levels__seqid___18874-66__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.120625 0.0294467 0.00004215688 None 39706196_Hannah-M.-Smith_bmi_discovery Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.008 0.002 0.000043 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.033731 0.00825187 0.00004380415 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0337305 0.00825187 0.00004381538 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0619657 0.0151642 0.0000440597 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore 0.0336 0.00825191 0.00004689843 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore -0.0335381 0.00825193 0.00004843345 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Madden RA Generation Scotland 33079621 2020-10-20 birthweight EFO_0004344 birthweight set 2 https://doi.org/10.7488/ds/2876, ST2, ST3 DNA methylation birthweight sex, gestational age, cell composition (reference based), epigenetic PCs, smoking, age Beta Values g Illumina HumanMethylationEPIC Whole blood None 362 1 Adults Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore 0.052 0.0127 0.000049 Beta is logFC 33079621_Madden-RA_birthweight_birthweight_set_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01482279 chr17:38083788 17 38083788 ORMDL3 Island -0.0344004 0.0084835 0.00005039823 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0412605 0.010184 0.00005115333 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23202472 chr17:38083134 17 38083134 ORMDL3 North shore 0.138007 0.0343375 0.00005865879 None 39706196_Hannah-M.-Smith_bmi_sensitivity Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg05271360 chr17:38083955 17 38083955 ORMDL3 Island 1.164295 0.2909 0.0000627 - 27105112_hiv_infection_discovery Gadd DA Generation Scotland 35945220 31/07/2022 TXNDC11 protein levels (SeqId = 9573-108) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNDC11 protein levels (SeqId = 9573-108) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin domain-containing protein 11 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.64 0.159 0.000063 None Gadd-DA_txndc11_protein_levels__seqid___9573-108__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0567187 0.0141938 0.00006472998 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf 1.4 0.345 0.000067 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04409495 chr17:38083144 17 38083144 ORMDL3 North shore 0.0329007 0.0082521 0.00006725463 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10444806 chr17:38084428 17 38084428 ORMDL3 South shore -0.0326964 0.00824504 0.00007356635 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09155575 chr17:38084037 17 38084037 ORMDL3 Island -0.0826247 0.0208386 0.00007369802 None 39706196_Hannah-M.-Smith_body_fat_discovery Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg08932654 chr17:38084459 17 38084459 ORMDL3 South shore 0.090489 0.0228424 0.0000745 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12655416 chr17:38077870 17 38077870 ORMDL3 Open sea -0.0326841 0.00825216 0.0000750942 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf -0.0325879 0.00825219 0.000078844 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea 0.0325507 0.0082522 0.00008034401 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P13671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P13671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0324645 0.00825222 0.00008391606 P13671 41361833_Josephine_Robertson_P13671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MCCD1 protein levels (SeqId = 8032-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MCCD1 protein levels (SeqId = 8032-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitochondrial coiled-coil domain protein 1 774 1 Adults (18-65 years) Both European cg10909506 chr17:38081995 17 38081995 ORMDL3 North shore 0.52 0.133 0.000086 None Gadd-DA_mccd1_protein_levels__seqid___8032-23__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22144450 chr17:38080378 17 38080378 ORMDL3 North shelf -0.0324135 0.00825223 0.00008610338 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MTMR6 protein levels (SeqId = 12536-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTMR6 protein levels (SeqId = 12536-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myotubularin-related protein 6 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.62 0.159 0.00009 None Gadd-DA_mtmr6_protein_levels__seqid___12536-46__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EXOSC1 protein levels (SeqId = 7930-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EXOSC1 protein levels (SeqId = 7930-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Exosome complex component CSL4 774 1 Adults (18-65 years) Both European cg18711369 chr17:38081186 17 38081186 ORMDL3 North shelf 0.62 0.158 0.000091 None Gadd-DA_exosc1_protein_levels__seqid___7930-3__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19511844 chr17:38084119 17 38084119 ORMDL3 South shore -0.115988 0.0297124 0.00009510027 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12749226 chr17:38077703 17 38077703 ORMDL3 Open sea -0.0553278 0.0141946 0.00009749934 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg15942003 chr17:38084581 17 38084581 ORMDL3 South shore 0.1241197 0.0318689 0.00009832 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort