author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05509609 chr4:74847829 4 74847829 PF4 Island -0.0041 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06834998 chr4:74847824 4 74847824 PF4 Island -0.0021 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore -0.0096 0.00029 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore 0.019 0.0016 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.0023 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16072462 chr4:74847758 4 74847758 PF4 Island -0.0026 0.00021 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore - - 8.33e-83 - 28056824_age_4_vs_age_0 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2731373 (gene symbol: PF4V1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2731373 (gene symbol: PF4V1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01447579 chr4:74847100 4 74847100 PF4 North shore None None 8.9e-31 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2731373__gene_symbol__pf4v1__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05509609 chr4:74847829 4 74847829 PF4 Island 0.003 None 7.6e-22 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore 0.06424 0.00721 3.9e-16 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg13126871 chr4:74848016 4 74848016 PF4 South shore -0.33941 0.0434 0.00000000000000503 - 25650246_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06834998 chr4:74847824 4 74847824 PF4 Island 0.0023 None 0.0000000000000065 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.13824 0.0188 0.00000000000021 - 25650246_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02530824 chr4:74847766 4 74847766 PF4 Island 0.0027 None 0.00000000000048 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15158783 chr4:74847646 4 74847646 PF4 Island 0.0024 None 0.0000000000015 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02530824 chr4:74847766 4 74847766 PF4 Island -0.0018 0.00026 0.0000000000029 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.0576025 0.00824286 0.000000000002905002 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15398841 chr4:74847761 4 74847761 PF4 Island 0.0024 None 0.000000000007 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22193091 chr4:74849299 4 74849299 PF4 South shore 0.0554824 0.00824385 0.00000000001757696 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15398841 chr4:74847761 4 74847761 PF4 Island -0.0015 0.00023 0.000000000075 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16072462 chr4:74847758 4 74847758 PF4 Island 0.0022 None 0.00000000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01447579 chr4:74847100 4 74847100 PF4 North shore 0.03944 0.0059 0.00000000024 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21043213 chr4:74847710 4 74847710 PF4 Island -0.0013 0.00021 0.00000000071 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore 0.0026 None 0.0000000014 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22193091 chr4:74849299 4 74849299 PF4 South shore 0.0494416 0.00824647 0.000000002076351 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.01773 0.00289 0.0000000046 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore 0.0089 0.0015 0.0000000086 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.0454499 0.00824804 0.00000003640644 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06834998 chr4:74847824 4 74847824 PF4 Island -0.06084 0.01118 0.00000016 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22193091 chr4:74849299 4 74849299 PF4 South shore 0.0414241 0.00824948 0.0000005189231 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22193091 chr4:74849299 4 74849299 PF4 South shore 0.0386412 0.00825041 0.000002844718 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore -0.0383245 0.00825051 0.000003428544 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg14882398 chr4:74848392 4 74848392 PF4 South shore -1.097389 0.2378 0.00000395 - 27105112_hiv_infection_discovery Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg13126871 chr4:74848016 4 74848016 PF4 South shore -0.013 0.00293174 0.00000462 - 28811542_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02530824 chr4:74847766 4 74847766 PF4 Island -0.023 0.0051 0.000005 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21043213 chr4:74847710 4 74847710 PF4 Island -0.017 0.0039 0.000017 None 33450751_Mulder-RH_sex_discovery Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg02530824 chr4:74847766 4 74847766 PF4 Island -0.0015 0.00037 0.000042 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg16072462 chr4:74847758 4 74847758 PF4 Island -0.0011 0.00027 0.000042 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg21043213 chr4:74847710 4 74847710 PF4 Island -0.0012 0.00029 0.000042 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15158783 chr4:74847646 4 74847646 PF4 Island -0.016 0.004 0.000043 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore 0.0337338 0.00825187 0.00004373925 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13126871 chr4:74848016 4 74848016 PF4 South shore -0.58 0.141 0.000044 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg16072462 chr4:74847758 4 74847758 PF4 Island 0.0139 0.00333 0.000051 None 34427971_Tan-Q_age_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16072462 chr4:74847758 4 74847758 PF4 Island -0.016 0.0038 0.000052 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22193091 chr4:74849299 4 74849299 PF4 South shore 0.0333166 0.00825199 0.00005431969 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg15158783 chr4:74847646 4 74847646 PF4 Island -0.0012 0.0003 0.000062 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg06834998 chr4:74847824 4 74847824 PF4 Island -0.0014 0.00034 0.000064 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05509609 chr4:74847829 4 74847829 PF4 Island 0.0059 0.0015 0.000071 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg21043213 chr4:74847710 4 74847710 PF4 Island -0.0011 0.00029 0.000075 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21043213 chr4:74847710 4 74847710 PF4 Island 0.0016 None 0.00008 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15398841 chr4:74847761 4 74847761 PF4 Island -0.016 0.0042 0.000081 None 33450751_Mulder-RH_sex_discovery Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg15158783 chr4:74847646 4 74847646 PF4 Island -0.0011 0.00029 0.000083 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15158783 chr4:74847646 4 74847646 PF4 Island -0.00089 0.00023 0.000087 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg21043213 chr4:74847710 4 74847710 PF4 Island 0.0131 0.00324 0.000088 None 34427971_Tan-Q_age_discovery Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg16072462 chr4:74847758 4 74847758 PF4 Island -0.001 0.00026 0.00009 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg02530824 chr4:74847766 4 74847766 PF4 Island -0.0014 0.00036 0.000093 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14882398 chr4:74848392 4 74848392 PF4 South shore 0.0082 0.0021 0.000096 None 33450751_Mulder-RH_sex_discovery