author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0022 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.0019 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore -0.0022 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0046 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.02 0.0013 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.022 0.0027 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0035 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.015 0.0011 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.018 0.0022 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0032 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.0031 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06763568 chr1:120284868 1 120284868 PHGDH Open sea 0.53331 0.00727 6.2999999999999995e-143 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.14037 0.00205 2.1e-137 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.50725 0.00763 5.4e-135 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.51864 0.0084 4.3999999999999994e-129 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore -0.35138 0.00614 5.3000000000000004e-123 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore 0.20185 0.00376 4.7e-118 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.44203 0.00927 1.1e-108 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.26974 0.00594 6.299999999999999e-105 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.554676 0.0268131 6.256589e-94 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.54811 0.026999 1.428645e-90 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.52676 0.0269232 2.498112e-84 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 4.62e-83 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore - - 1.56e-81 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.1514 0.00816139 5.931703e-76 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.527637 0.0284788 6.751695e-76 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.523968 0.0283772 2.122079e-75 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -3.1 0.172 4.1999999999999996e-70 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.502531 0.0283181 7.725985999999999e-70 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.463194 0.0261278 1.054113e-69 None 39706196_Hannah-M.-Smith_body_fat_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -2.9 0.163 4.999999999999999e-69 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.458263 0.0260721 1.463549e-68 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.435793 0.0260737 3.194903e-62 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.445908 0.027469 8.004341e-59 None 39706196_Hannah-M.-Smith_body_fat_discovery Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore - - 1.96e-57 - 28056824_age_4_vs_age_0 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.514991 0.0331283 3.980695e-54 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.127151 0.00818956 6.21255e-54 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.127027 0.00818969 7.872776000000001e-54 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.42175 0.0274058 4.353887e-53 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.512887 0.033348 5.0182040000000015e-53 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.125658 0.00819113 1.0473610000000001e-52 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.418124 0.0274306 3.999153e-52 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.50572 0.0332315 5.828338000000001e-52 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.124426 0.0084186 4.455788e-49 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.119974 0.00819693 3.59286e-48 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -3.1 0.215 3.7999999999999997e-47 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.453948 0.0319231 1.24435e-45 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.449862 0.0318527 4.864359e-45 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.438288 0.031837 6.810134e-43 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.125046 0.00915622 3.323638e-42 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.11121 0.00820536 1.34809e-41 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.110946 0.0082056 2.08717e-41 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.112887 0.00842099 9.760275e-41 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.109534 0.00820689 2.134546e-40 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.121391 0.00917462 9.800052e-40 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.10848 0.00820785 1.1861070000000001e-39 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 2.2e-39 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.110107 0.0084521 1.403158e-38 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.109899 0.00843751 1.4437089999999998e-38 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.117679 0.00917234 1.776116e-37 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.102037 0.00821348 2.943648e-35 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.101922 0.00821357 3.508593e-35 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.101775 0.0082137 4.383742e-35 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg06763568 chr1:120284868 1 120284868 PHGDH Open sea 1.58876 0.07846 1.12e-34 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.101019 0.00821434 1.376497e-34 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Richard MA CHARGE 29198723 2019-11-25 Systolic Blood Pressure EFO_0006335 Meta-analysis Table S4 DNA methylation Systolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0003 None 2.7e-34 None 29198723_Richard-MA_systolic_blood_pressure_meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 6.2000000000000004e-34 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0996981 0.00821544 9.9412e-34 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0995276 0.00821558 1.28071e-33 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0994772 0.00821562 1.380156e-33 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0992077 0.00820904 1.824464e-33 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0984298 0.00821648 6.476375e-33 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0971222 0.00821754 4.3590440000000003e-32 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0960725 0.00821838 1.977458e-31 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0990577 0.00853531 5.271044e-31 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0974682 0.00844695 1.139909e-30 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0935885 0.00822033 6.630949e-30 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 2.2e-29 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0913335 0.00822206 1.485229e-28 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 Discovery and replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood Weighted Z-test meta-analysis 10238 13 54.5 Both European,South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 1.5000000000000002e-28 - 28002404_body_mass_index_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.093634 0.00846542 2.5164050000000003e-28 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0893576 0.00822354 2.126675e-27 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0891746 0.00822368 2.7131820000000003e-27 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0993122 0.00927635 1.1972669999999999e-26 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0983849 0.00919234 1.236777e-26 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.087792 0.00822469 1.681438e-26 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0875572 0.00822486 2.285595e-26 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0979421 0.00920975 2.565008e-26 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0976693 0.00920972 3.513163e-26 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0870513 0.00822523 4.415665e-26 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0865371 0.0082256 8.590907999999999e-26 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0945761 0.00902302 1.2925960000000001e-25 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0856084 0.00821232 2.353096e-25 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0945942 0.00912192 4.147003e-25 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0958603 0.00926214 5.119276000000001e-25 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0849985 0.00822669 6.1458130000000005e-25 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0909584 0.0088051 6.266729999999999e-25 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0948268 0.00920613 8.524e-25 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0861493 0.0083881 1.160929e-24 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0841599 0.00822728 1.769762e-24 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0908866 0.00891214 2.43859e-24 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0838503 0.00822749 2.6083900000000002e-24 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0835435 0.00822771 3.825555e-24 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0834858 0.00822775 4.110421e-24 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0911042 0.00899197 4.794293e-24 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0831542 0.00822798 6.205871e-24 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0931159 0.00921369 6.207835e-24 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0829948 0.00822809 7.560771e-24 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0830428 0.00824059 8.322304e-24 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.082556 0.00822839 1.2996730000000001e-23 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0823823 0.00822851 1.609206e-23 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0872762 0.00873815 2.04512e-23 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0819974 0.00822877 2.579457e-23 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Petersen A-K KORA F4 24014485 2013-09-06 M32197_3-4-hydroxyphenyllactate EFO_0004727, EFO_0004725 no snps model Table S2 M32197_3-4-hydroxyphenyllactate DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 3.8 0.067 2.6e-23 None 24014485_Petersen-A-K_m32197_3-4-hydroxyphenyllactate_no_snps_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0915412 0.00920427 3.1251120000000005e-23 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 3.8e-23 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0914673 0.00921872 3.9539980000000005e-23 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0815316 0.00822908 4.552192e-23 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0815057 0.0082291 4.697681e-23 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0971396 0.00984248 6.659436e-23 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0854072 0.00865807 6.995233e-23 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0807325 0.00822962 1.197163e-22 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Richard MA CHARGE 29198723 2019-11-25 Systolic Blood Pressure EFO_0006335 Meta-analysis Table S4 DNA methylation Systolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0002 None 1.2e-22 None 29198723_Richard-MA_systolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0827476 0.00847384 1.861572e-22 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0830239 0.00853161 2.589916e-22 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.079977 0.00823012 2.961026e-22 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0799262 0.00823016 3.1457499999999997e-22 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0795808 0.00823039 4.74486e-22 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0816874 0.00847813 6.60149e-22 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0792591 0.0082306 6.94549e-22 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0790921 0.00821549 7.1246560000000005e-22 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0791995 0.00822884 7.303349e-22 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0791575 0.00823066 7.831701e-22 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0790843 0.00823071 8.538838e-22 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0830737 0.00864834 8.766792e-22 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.091275 0.00953031 1.152487e-21 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.080627 0.00846938 2.000355e-21 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Richard MA CHARGE 29198723 2019-11-25 Diastolic Blood Pressure EFO_0006336 Meta-analysis Table S4 DNA methylation Diastolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0004 None 2.1e-21 None 29198723_Richard-MA_diastolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0779466 0.00823145 3.237108e-21 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0790087 0.00839492 5.60593e-21 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0773986 0.0082318 6.108642e-21 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Petersen A-K KORA F4 24014485 2013-09-06 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* EFO_0004727, EFO_0004725 snps as covariates model Table S4 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.93 0.12 6.5e-21 None 24014485_Petersen-A-K_m37202_4-androsten-3betacomma17beta-diol_disulfate_1__snps_as_covariates_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0771774 0.00828372 1.367218e-20 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0766939 0.00823225 1.373391e-20 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0875705 0.00943174 1.846165e-20 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0762274 0.00821072 1.859174e-20 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.250214 0.0271151 3.0625279999999997e-20 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0749892 0.00816522 4.701461e-20 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0752499 0.00823316 7.060383e-20 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0847926 0.00928221 7.385607999999999e-20 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0773245 0.00847622 8.279356e-20 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0778616 0.00854664 9.269453999999999e-20 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0748877 0.00823339 1.059376e-19 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0748081 0.00823344 1.15788e-19 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0769336 0.00846793 1.164449e-19 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.074532 0.00823361 1.5751909999999998e-19 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0749264 0.00828908 1.7731319999999998e-19 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.074313 0.008231 1.9550359999999997e-19 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 2.1e-19 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0738456 0.00823403 3.3687929999999995e-19 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0165689 0.0018504 3.43e-19 - 28213390_serum_triglycerides_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0758755 0.00847892 4.0210929999999994e-19 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0844319 0.00944598 4.413446e-19 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0733565 0.00823433 5.765829e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0729004 0.0082346 9.486747999999998e-19 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0727901 0.00823467 1.069632e-18 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0787613 0.00892858 1.2577370000000001e-18 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0725183 0.00823483 1.436462e-18 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0723482 0.00823493 1.7265290000000001e-18 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 Discovery and replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood Weighted Z-test meta-analysis 10238 13 54.5 Both European,South Asian cg16246545 chr1:120255941 1 120255941 PHGDH South shore - - 1.8e-18 - 28002404_body_mass_index_discovery_and_replication Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.231309 0.0264181 2.2029060000000002e-18 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.227237 0.0260117 2.625556e-18 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0806719 0.00927514 3.743724e-18 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0833968 0.00961095 4.476147e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry discovery Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 2707 3 57.9 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -13.48 1.56 4.5e-18 - 28002404_body_mass_index_european_ancestry_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0716041 0.00832737 8.873808e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.1 0.012 9.2e-18 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0703055 0.00819851 1.0853760000000001e-17 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 1.2e-17 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0704439 0.00823606 1.3154780000000001e-17 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0700696 0.00823628 1.9484e-17 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry discovery Table S3 Body mass index DNA mehtylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 5387 4 54.5 Both European,South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore -14.5 1.6 2.1e-17 - 28002404_body_mass_index_all_ancestry_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.046 0.00543 2.1e-17 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.06773 0.00797095 2.1291170000000002e-17 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0698432 0.00823641 2.4685880000000003e-17 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0781083 0.00921234 2.493163e-17 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.069538 0.00823658 3.3920890000000004e-17 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0694876 0.00823661 3.57461e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0828124 0.00981978 3.673954e-17 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26612362 chr1:120254619 1 120254619 PHGDH North shore 0.00921 0.001 4.5e-17 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0693315 0.00824902 4.67593e-17 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0772566 0.00922248 5.917704000000001e-17 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0763796 0.0091233 6.176434e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -1.5 0.184 6.5e-17 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0685349 0.00823716 9.547288000000001e-17 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0684474 0.00823721 1.044249e-16 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0702707 0.00847005 1.166072e-16 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg06763568 chr1:120284868 1 120284868 PHGDH Open sea -0.19871 0.024 1.18e-16 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0701416 0.00847012 1.325477e-16 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0761594 0.0092192 1.56779e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0703808 0.00854225 1.880057e-16 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0698325 0.00848886 2.090755e-16 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0675073 0.00823774 2.714176e-16 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0675035 0.00823774 2.724554e-16 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0755133 0.00921859 2.793268e-16 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0699612 0.00859321 4.218255e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0670294 0.008238 4.389286e-16 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0670277 0.008238 4.396634e-16 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0749652 0.00921593 4.472964e-16 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.215438 0.0265238 4.858584e-16 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0668515 0.0082381 5.244348e-16 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Ligthart S CHARGE 27955697 2016-12-12 C-reactive protein EFO_0004458 Discovery Table S3 DNA methylation C-reactive protein Age, sex, smoking, body mass index, cell counts and technical covariates Beta values mg/l Illumina HumanMethylation450 Whole blood C-reactive protein levels were log-transformed 8863 9 65 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0068 0.000839 5.29e-16 - 27955697_creactive_protein_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0669457 0.00827887 6.626844e-16 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0665814 0.00823825 6.866364e-16 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0664891 0.0082383 7.526894e-16 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0742511 0.0092291 9.25649e-16 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0679397 0.00847723 0.000000000000001189986 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0737538 0.0092264 0.000000000000001405742 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0702359 0.00880763 0.000000000000001643393 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.227933 0.0286192 0.000000000000001760084 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0656273 0.00823877 0.000000000000001763511 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.065616 0.00823878 0.000000000000001783115 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0675287 0.00848727 0.000000000000001899171 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0731242 0.00921351 0.00000000000000222715 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.065278 0.00823896 0.000000000000002482543 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -1.4 0.173 0.0000000000000026 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0671381 0.00848668 0.000000000000002735054 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.008 0.001 0.0000000000000031 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0668153 0.00847345 0.000000000000003359312 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0724983 0.00920886 0.000000000000003713436 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0647377 0.00823925 0.000000000000004198614 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0694573 0.00884317 0.000000000000004296554 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Aslibekyan S - 26110892 2015-07-01 Body mass index EFO_0004340 Meta-analysis Table 2 DNA methylation Body mass index Age, sex, smoking, study centre and technical covariates Beta values kg/m2 Illumina HumanMethylation450 CD4+ T-cells, leukocytes and whole blood - 5474 4 59.1 Both European,African cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 0.0000000000000047 - 26110892_body_mass_index_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0769769 0.00982396 0.000000000000004984556 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0644811 0.00823939 0.00000000000000538113 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0643526 0.00823946 0.000000000000006090142 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0018 None 0.000000000000007 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0766306 0.00985566 0.000000000000008027228 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0641331 0.00825256 0.000000000000008282423 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0639538 0.00823967 0.000000000000008931571 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0639016 0.0082397 0.000000000000009389101 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0656134 0.00848688 0.00000000000001134803 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.063621 0.00823984 0.0000000000000122717 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0695691 0.00901039 0.00000000000001228779 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0215042 0.0027886 0.0000000000000125 - 28213390_serum_triglycerides_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.097 0.0126 0.000000000000015 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Petersen A-K KORA F4 24014485 2013-09-06 M32197_3-4-hydroxyphenyllactate EFO_0004727, EFO_0004725 no snps model Table S2 M32197_3-4-hydroxyphenyllactate DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 3.3 0.081 0.000000000000016 None 24014485_Petersen-A-K_m32197_3-4-hydroxyphenyllactate_no_snps_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0648769 0.00844913 0.00000000000001710871 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0627997 0.00824389 0.00000000000002739371 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0627185 0.00824215 0.00000000000002919207 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0700339 0.00921514 0.00000000000003143515 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0624857 0.00824044 0.00000000000003583901 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0623303 0.00824052 0.00000000000004143984 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.210405 0.0278576 0.00000000000004458641 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.245727 0.0325354 0.00000000000004467368 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0696122 0.00923545 0.00000000000005070556 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.11 0.0146 0.000000000000054 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0620411 0.00824067 0.00000000000005424907 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0678349 0.0090402 0.00000000000006560995 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0618251 0.00824078 0.00000000000006628603 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0679437 0.00906196 0.00000000000006867366 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0677052 0.00904458 0.00000000000007520002 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0638368 0.00852884 0.00000000000007571961 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.061606 0.00824089 0.0000000000000811628 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0615734 0.00824091 0.00000000000008364124 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0671659 0.00901078 0.00000000000009565936 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0675747 0.00907135 0.00000000000009910735 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0622144 0.00835236 0.00000000000009950645 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0612404 0.00824837 0.000000000000119397 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.06851 0.009233 0.0000000000001234352 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0612832 0.00826094 0.0000000000001250159 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0629579 0.00849232 0.0000000000001297283 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0714127 0.00964448 0.0000000000001387969 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.06102 0.00824119 0.0000000000001390408 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0683757 0.00923618 0.0000000000001403459 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0609906 0.0082412 0.0000000000001428277 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Meta-analysis Table S2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 1450 2 63.5 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.017 0.002 0.00000000000018 - 28624579_gammaglutamyl_transferase_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0666971 0.0090566 0.0000000000001873239 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0606107 0.00824139 0.0000000000002018888 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0657434 0.00895495 0.0000000000002222276 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0603862 0.0082415 0.0000000000002474799 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0603581 0.00824152 0.0000000000002538371 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0610896 0.00834964 0.0000000000002678565 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.042 0.00571 0.00000000000028 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0602368 0.00824158 0.0000000000002832632 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0600837 0.00824165 0.0000000000003251967 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11551257 chr1:120255387 1 120255387 PHGDH Island 0.00025 0.000035 0.00000000000033 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0671384 0.00922507 0.0000000000003564795 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0599624 0.00824171 0.0000000000003626759 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0599482 0.00824172 0.0000000000003673535 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0616273 0.00847325 0.0000000000003689467 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0669092 0.00921522 0.0000000000004043824 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0658386 0.00906865 0.0000000000004064824 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.205655 0.0283537 0.0000000000004242779 None 39706196_Hannah-M.-Smith_bmi_sensitivity Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry discovery Table S3 Body mass index DNA mehtylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 5387 4 54.5 Both European,South Asian cg16246545 chr1:120255941 1 120255941 PHGDH South shore -14 1.8 0.00000000000048 - 28002404_body_mass_index_all_ancestry_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.287512 0.0399873 0.0000000000006740647 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0591691 0.00824211 0.0000000000007365563 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0591043 0.00824214 0.0000000000007801638 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0591468 0.00825402 0.0000000000008100938 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0589485 0.00824221 0.0000000000008955074 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4851 9 54.5 Both European,South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore -8.9 1.2 0.00000000000094 - 28002404_body_mass_index_all_ancestry_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0677844 0.00954165 0.000000000001267359 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0655557 0.00923292 0.000000000001302845 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based), body mass index Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.0000000000014 None 31386212_Xu-K_alcohol_consumption_adjusted_for_bmi Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.00060598 8.57e-05 0.00000000000154 - 27843151_alcohol_consumption_per_day_european_ancestry Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0024 None 0.0000000000016 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0582109 0.00824257 0.000000000001712306 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0587579 0.00832949 0.000000000001813594 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based), body mass index Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 0.0000000000019 None 31386212_Xu-K_alcohol_consumption_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0630408 0.00894658 0.000000000001918602 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0594759 0.00844087 0.000000000001920984 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0580382 0.00824265 0.000000000001990563 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.068692 0.00975634 0.000000000001997166 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0135 0.0019 0.00000000000205 - 28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry discovery Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 2707 3 57.9 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -12.9 1.84 0.0000000000021 - 28002404_body_mass_index_european_ancestry_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0579494 0.0082427 0.000000000002150482 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.200614 0.0285402 0.000000000002155306 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0596482 0.00848711 0.000000000002186265 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0594354 0.00847112 0.000000000002378989 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0577643 0.00824279 0.000000000002525287 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.190805 0.0273225 0.000000000002981346 None 39706196_Hannah-M.-Smith_glucose_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.046 0.00662 0.000000000003 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.057533 0.0082429 0.000000000003084745 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0576361 0.00825932 0.000000000003115404 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0574251 0.00824295 0.000000000003385714 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Petersen A-K KORA F4 24014485 2013-09-06 M32197_3-4-hydroxyphenyllactate EFO_0004727, EFO_0004725 snps as covariates model Table S4 M32197_3-4-hydroxyphenyllactate DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 3.1 0.088 0.0000000000036 None 24014485_Petersen-A-K_m32197_3-4-hydroxyphenyllactate_snps_as_covariates_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0617159 0.00887782 0.000000000003761648 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.231507 0.0333818 0.000000000004196832 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0570176 0.00824314 0.000000000004804771 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05958127 chr1:120254177 1 120254177 PHGDH North shore 0.04348 0.0059 0.0000000000049 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.056916 0.00824319 0.000000000005240805 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.03546 0.00482 0.0000000000055 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.196129 0.028438 0.000000000005505906 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0560688 0.00814953 0.00000000000622772 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.065541 0.0095571 0.000000000007271171 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0565097 0.00824338 0.00000000000740754 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0564988 0.00824338 0.000000000007476246 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0743433 0.0108503 0.00000000000758879 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0675574 0.00987744 0.000000000008258614 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0635157 0.0092905 0.000000000008428037 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0562229 0.0082468 0.000000000009622482 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0614285 0.0090109 0.00000000000965048 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0530179 0.00778358 0.00000000001003385 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0576331 0.0084797 0.00000000001112569 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0560198 0.00824361 0.00000000001120646 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0667201 0.00982523 0.00000000001158979 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0631247 0.00930708 0.00000000001226922 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0557399 0.00824374 0.00000000001417423 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0619949 0.009245 0.00000000002076692 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0552763 0.00824395 0.00000000002086564 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Meta-analysis Table S2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 1450 2 63.5 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.014 0.002 0.000000000022 - 28624579_gammaglutamyl_transferase_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0614564 0.00918535 0.00000000002301577 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.186773 0.0279899 0.00000000002580425 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0565651 0.00849478 0.00000000002858826 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0657489 0.00987746 0.00000000002904912 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0548741 0.00824413 0.0000000000291091 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0569362 0.00855591 0.00000000002941404 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 not adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based) Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000000000032 None 31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0612346 0.00921936 0.00000000003204445 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.263826 0.0397385 0.00000000003250838 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0564518 0.00855507 0.00000000004291917 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0544552 0.00826064 0.00000000004483616 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0543365 0.00824437 0.00000000004525788 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 not adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based) Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 0.000000000049 None 31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi Mendelson MM - 28095459 2017-01-17 Body mass index EFO_0004340 Meta-analysis Table S1 DNA methylation Body mass index Age, sex, cell counts and technical covariates Beta values kg/m2 Illumina HumanMethylation450 Whole blood Weighted Z-test meta-analysis 3743 4 69.2 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 0.0000000000503 - 28095459_body_mass_index_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0528719 0.00804222 0.00000000005053574 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0541535 0.00824446 0.00000000005254598 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0541216 0.00824447 0.00000000005392562 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Wilson LE Sister Study 30938765 2019-02-14 Alcohol Consumption EFO_0004329, EFO_0007878 replication Web Table 1 DNA methylation Alcohol Consumption Age, breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based) M Values drinks per week Illumina HumanMethylation450 Whole blood Discovery P-value not reported 187 1 Adults Females Unclear cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000000000055 None 30938765_Wilson-LE_alcohol_consumption_replication Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4195 8 54.6 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -7.08 1.08 0.000000000057 - 28002404_body_mass_index_european_ancestry_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.052928 0.00807657 0.00000000005816705 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0586139 0.00898114 0.00000000006961556 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0099701 0.0015335 0.0000000000796 - 28213390_serum_triglycerides_discovery_and_replication Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0187794 0.0028965 0.0000000000896 - 28213390_serum_triglycerides_discovery_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0534903 0.00824475 0.00000000008989422 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0518859 0.00799881 0.0000000000905471 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0640036 0.00988109 0.00000000009630525 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0548145 0.00849318 0.000000000112403 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0531804 0.00824489 0.0000000001152702 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.053173 0.00824489 0.0000000001159621 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf - - 0.00000000012 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0593178 0.00923697 0.0000000001388368 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.0529215 0.008245 0.0000000001417383 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0529096 0.00824501 0.0000000001430904 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0532271 0.00829699 0.0000000001449164 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0526688 0.00824511 0.0000000001732704 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0525019 0.00824518 0.0000000001977501 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0524704 0.0082452 0.0000000002027302 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0524577 0.0082452 0.0000000002047773 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0524341 0.00824521 0.0000000002086236 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.207179 0.032673 0.0000000002336482 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.05227 0.00824528 0.0000000002374311 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0618925 0.00977291 0.0000000002473504 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.160885 0.0254341 0.0000000002581903 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Cardona A EPIC-Norfolk 31506343 2019-09-10 Type II diabetes EFO_0001360 Discovery Table 2 Type II diabetes DNA methylation Age, sex, cell composition (reference based), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 1264 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.4 None 0.00000000028 None 31506343_Cardona-A_type_ii_diabetes_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0520577 0.00824538 0.0000000002805205 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg10827253 chr1:120253477 1 120253477 PHGDH North shore -0.0279 0.00452408 0.000000000348 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0517251 0.00824552 0.0000000003638324 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.00094059 0.0001501 0.000000000369 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0516889 0.00824553 0.0000000003742197 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0516855 0.00824554 0.0000000003752076 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0516522 0.00824555 0.0000000003850687 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0577866 0.00924131 0.0000000004136013 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0579474 0.00929414 0.0000000004646497 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0545536 0.0087544 0.0000000004744617 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0563869 0.00906063 0.0000000005001044 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0504643 0.00811 0.0000000005026939 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0495919 0.00797241 0.0000000005092165 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0512837 0.00824571 0.0000000005124523 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0511809 0.00824575 0.0000000005548032 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0671112 0.010818 0.000000000566384 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0519707 0.00838049 0.0000000005746837 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0510686 0.0082458 0.0000000006049368 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.239843 0.0387483 0.0000000006154266 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg00426921 chr1:120254845 1 120254845 PHGDH Island 0.00608 0.001 0.000000000658 - 23334450_rheumatoid_arthritis Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 1 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 1 = adjusted for sex + age 3400 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.00000000067 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.031 0.00508 0.00000000072 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0567367 0.00920237 0.000000000721289 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0508283 0.0082459 0.0000000007275399 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.227771 0.0370741 0.0000000008239738 None 39706196_Hannah-M.-Smith_body_fat_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.0069 0.0011 0.00000000084 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0599867 0.00978449 0.0000000008968572 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.052831 0.00862562 0.0000000009306569 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.243843 0.0398585 0.0000000009696 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0504124 0.00824607 0.0000000009993944 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0564148 0.00923709 0.000000001038148 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0503461 0.0082461 0.000000001050981 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.078 0.0128 0.0000000011 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Richard MA CHARGE 29198723 2019-11-25 Diastolic Blood Pressure EFO_0006336 Meta-analysis Table S4 DNA methylation Diastolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0002 None 0.0000000011 None 29198723_Richard-MA_diastolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0545761 0.00895161 0.00000000110934 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Ligthart S CHARGE 27955697 2016-12-12 C-reactive protein EFO_0004458 Discovery Table S3 DNA methylation C-reactive protein Age, sex, smoking, body mass index, cell counts and technical covariates Beta values mg/l Illumina HumanMethylation450 Whole blood C-reactive protein levels were log-transformed 8863 9 65 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0042 0.000691 0.00000000123 - 27955697_creactive_protein_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0501275 0.00824619 0.00000000124031 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0532386 0.00878491 0.000000001392565 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0498348 0.00824631 0.000000001546674 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.191162 0.0317103 0.000000001688714 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0497119 0.00824636 0.000000001696238 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0496518 0.00824639 0.000000001774353 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0496488 0.00824639 0.000000001778402 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.78 0.13 0.0000000018 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0496196 0.0082464 0.000000001817683 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0624526 0.0103796 0.00000000182044 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0495969 0.00824641 0.000000001848878 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0512073 0.00851479 0.000000001853854 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0495818 0.00824642 0.000000001869816 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0495412 0.00824827 0.000000001943414 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0586192 0.00977006 0.000000002021156 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_4 Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 2 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 2 = model 1 + smoking + physical activity + alcohol consumption 3400 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.0000000021 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.053871 0.0089935 0.000000002147769 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0494549 0.00826357 0.000000002218446 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0519932 0.00869177 0.000000002256981 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0493053 0.00824653 0.00000000229835 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.06432 0.010759 0.000000002307883 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0493907 0.00826221 0.000000002312683 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.78 0.131 0.0000000024 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0549679 0.00923069 0.000000002661699 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0504989 0.00848742 0.000000002744933 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based), body mass index Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg26457483 chr1:120256112 1 120256112 PHGDH South shore None None 0.0000000028 None 31386212_Xu-K_alcohol_consumption_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.050471 0.00848756 0.000000002802197 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0522506 0.00878793 0.000000002815047 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.81 0.136 0.0000000029 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0550492 0.00927083 0.000000002952418 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0524417 0.00884955 0.000000003175261 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0488356 0.00824672 0.00000000325505 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0488182 0.00824673 0.000000003297066 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0502957 0.00849819 0.000000003323368 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0487765 0.00824674 0.000000003400047 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 0.0487639 0.00824675 0.000000003431863 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.158028 0.0267288 0.0000000034344 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.00048701 8.17e-05 0.00000000345 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0579423 0.00980647 0.000000003527338 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.048785 0.0082604 0.000000003585143 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.218253 0.0369925 0.000000003704759 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0571843 0.00973183 0.000000004293976 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg10827253 chr1:120253477 1 120253477 PHGDH North shore -0.10167 0.0173 0.0000000044 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0483953 0.0082469 0.000000004497704 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0483736 0.00824691 0.000000004569562 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0505929 0.00865647 0.000000005188489 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0481965 0.00824698 0.000000005199909 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0684631 0.0117308 0.00000000545433 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0481267 0.00824749 0.000000005482458 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0499228 0.0085607 0.000000005604779 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0480729 0.00824703 0.000000005689208 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0480652 0.00824703 0.000000005720842 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0510849 0.00876901 0.000000005809525 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.18115 0.0311012 0.000000005823634 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05958127 chr1:120254177 1 120254177 PHGDH North shore -0.0092 0.0016 0.000000006 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0513642 0.00883267 0.00000000618077 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0479538 0.00824707 0.000000006202748 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0479402 0.00824708 0.00000000626431 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0481824 0.00829055 0.000000006311615 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0478865 0.0082471 0.000000006512747 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 CD14+ monocytes Table S7 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 CD14+ monocytes - 1251 1 60 Both European,African,Admixed cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.000714 0.000122 0.00000000662 - 27843151_alcohol_consumption_per_day_cd14_monocytes Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0489861 0.00844904 0.000000006855808 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0478143 0.00824713 0.000000006861885 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0492043 0.00849338 0.000000007045515 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -1.3 0.225 0.0000000071 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0477639 0.00824715 0.000000007115927 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0126024 0.0021842 0.00000000794 - 28213390_serum_triglycerides_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0532866 0.00924158 0.000000008283029 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0474588 0.00824727 0.000000008863984 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.326305 0.0570648 0.00000001094699 None 39706196_Hannah-M.-Smith_bmi_discovery Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Discovery Table 2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 731 1 59.6 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.017 0.003 0.000000011 - 28624579_gammaglutamyl_transferase_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0469592 0.00824746 0.00000001266385 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0480198 0.00846594 0.0000000143709 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.0467741 0.00824753 0.00000001444015 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0466916 0.00824757 0.00000001530808 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0466751 0.00824757 0.00000001548817 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0465438 0.008239 0.00000001641849 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Aslibekyan S - 26110892 2015-07-01 Waist circumference EFO_0004342 Discovery GOLDN Table 3 DNA methylation Waist circumference Age, sex, smoking, study centre and technical covariates Beta values cm Illumina HumanMethylation450 CD4+ T-cells - 991 1 49 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -6e-04 1e-04 0.000000017 - 26110892_waist_circumference_discovery_goldn Aslibekyan S - 26110892 2015-07-01 Body mass index EFO_0004340 FHS 1 Table 2 DNA methylation Body mass index Age, sex and technical covariates Beta values kg/m2 Illumina HumanMethylation450 Whole blood - 1935 1 65 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.02 0.004 0.000000017 - 26110892_body_mass_index_fhs_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 0.0465264 0.00824763 0.00000001720024 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0464875 0.00824765 0.00000001767749 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0464427 0.00824766 0.00000001824379 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0463863 0.00824768 0.00000001898129 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore 0.0068 0.0012 0.000000019 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mendelson MM - 28095459 2017-01-17 Body mass index EFO_0004340 Framingham Heart Study Batch 2 Table S1 DNA methylation Body mass index Age, sex and technical covariates - kg/m2 Illumina HumanMethylation450 Whole blood DNA methylation was inverse normally rank transformed 1935 1 67 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0232 0.0041 0.000000019 - 28095459_body_mass_index_framingham_heart_study_batch_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.046255 0.00824773 0.00000002081267 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0476424 0.00850139 0.00000002131481 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0462157 0.00824775 0.00000002139332 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Aslibekyan S - 26110892 2015-07-01 Waist circumference EFO_0004342 Meta-analysis Table 3 DNA methylation Waist circumference Age, sex, smoking, study centre and technical covariates Beta values cm Illumina HumanMethylation450 CD4+ T-cells and leukocytes - 3097 2 53.8 Both European,African cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 0.000000022 - 26110892_waist_circumference_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0460427 0.00824782 0.00000002414087 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0451775 0.00810041 0.00000002487632 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0474042 0.00850231 0.00000002512475 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.054621 0.00980601 0.0000000258991 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0512034 0.00920114 0.00000002669037 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0459274 0.00825541 0.00000002693447 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 not adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based) Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg26457483 chr1:120256112 1 120256112 PHGDH South shore None None 0.000000027 None 31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0458483 0.00824789 0.00000002763883 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0459834 0.00827259 0.00000002768074 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0458195 0.0082479 0.0000000281963 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0469764 0.00846356 0.00000002899067 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0509904 0.00919516 0.00000002984254 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.029 0.00487 0.000000031 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0511864 0.00924601 0.0000000314676 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0456565 0.00824796 0.00000003156765 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0456408 0.00824797 0.00000003191331 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Battram T ARIES None 2020-08-20 Ratio of omega 6 fatty acids to total fatty acids EFO_0005110 None None DNA methylation Ratio of omega 6 fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.072 0.013 0.000000033 None Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0455364 0.00824801 0.00000003430023 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0454942 0.00824802 0.00000003531286 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0456066 0.00829714 0.00000003935175 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.074 0.0135 0.000000042 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0451001 0.00824817 0.00000004628591 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0450945 0.00824817 0.00000004646432 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0450921 0.00824817 0.00000004654142 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0448674 0.00820762 0.00000004663674 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Karabegovic I Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK, ARIC, CHS, EPIC 33990564 05-14-2021 Coffee and tea consumption None Meta-analysis Table 2 DNA methylation Coffee and tea consumption Age, Sex, Smoking, Cell composition (reference based), Batch effects, Alcohol consumption Beta values None Illumina HumanMethylation450 Whole blood None 15789 15 Adults Both European, African cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0011 0.0002 0.000000047 None 33990564_Karabegovic-I_coffee_and_tea_consumption_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0462627 0.00846596 0.00000004716257 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0449357 0.00823299 0.00000004893504 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.150988 0.0277628 0.00000005441859 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.04663 0.0085742 0.00000005462036 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0473006 0.00870112 0.00000005531289 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05084811 chr1:120279236 1 120279236 PHGDH Open sea 0.0448216 0.00824827 0.000000055965 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0447276 0.00823472 0.00000005674306 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.044795 0.00824828 0.00000005698762 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Battram T ARIES None 2020-08-20 Ratio of 18:2 linoleic acid to total fatty acids EFO_0006807, EFO_0005110 None None DNA methylation Ratio of 18:2 linoleic acid to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.067 0.0123 0.000000057 None Battram-T_ratio_of_18_2_linoleic_acid_to_total_fatty_acids Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0440094 0.00810403 0.00000005707452 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.194657 0.0358933 0.00000005928405 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0499161 0.00920738 0.00000006009668 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Aslibekyan S - 26110892 2015-07-01 Body mass index EFO_0004340 Discovery GOLDN Table 2 DNA methylation Body mass index Age, sex, smoking, study centre and technical covariates Beta values kg/m2 Illumina HumanMethylation450 CD4+ T-cells - 991 1 49 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0015 3e-04 0.000000066 - 26110892_body_mass_index_discovery_goldn Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore - - 0.0000000674 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0445216 0.00825777 0.00000007096065 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Jiantao Ma FHS 30796027 Feb 22, 2019 hepatic fat EFO_0010821 Discovery Table 1 DNA methylation hepatic fat Age, Sex, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylation450 whole blood None 1496 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000000075 None 30796027_Jiantao-Ma_hepatic_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0625199 0.0116217 0.00000007581155 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0443227 0.00824846 0.0000000784251 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0496517 0.00924345 0.00000007925079 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0449005 0.00836407 0.00000008071309 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 DEFB1 protein levels (SeqId = 6629-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB1 protein levels (SeqId = 6629-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.725 0.136 0.000000093 None Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0478712 0.00896657 0.00000009493153 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.136242 0.0255246 0.00000009526625 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea -0.0439837 0.00824858 0.0000000984265 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0466595 0.0087673 0.0000001041511 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0495446 0.00931643 0.000000106467 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0437084 0.00822015 0.0000001069083 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0437374 0.00824867 0.0000001159768 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0516825 0.00974976 0.0000001169014 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0437159 0.00824868 0.0000001176409 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0436589 0.0082487 0.0000001221771 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0436764 0.00825359 0.0000001228542 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore -0.00068981 0.00012969 0.000000127 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0435859 0.00824873 0.0000001282307 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.001 None 0.00000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.082 0.0155 0.00000013 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0446298 0.00845894 0.0000001338766 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0434484 0.00824877 0.0000001404388 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.043431 0.00824878 0.000000142058 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0434076 0.00825673 0.000000148288 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0484275 0.0092264 0.0000001552346 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0432465 0.00824885 0.0000001604094 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0431247 0.00823372 0.0000001649537 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0430947 0.0082489 0.000000177212 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.163849 0.0313819 0.0000001797806 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0052 0.00093 0.00000018 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0495921 0.00950851 0.0000001857662 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0481052 0.00922869 0.0000001887755 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.053842 0.0103426 0.0000001957044 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.0252 0.00469 0.0000002 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0507599 0.00976972 0.0000002067648 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0481326 0.00926981 0.0000002103747 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.045294 0.00873551 0.000000218841 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_4 Battram T ARIES None 2020-08-20 Mean diameter for VLDL particles EFO_0008594 None None DNA methylation Mean diameter for VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values nm Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.133 0.026 0.00000023 None Battram-T_mean_diameter_for_vldl_particles Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.7 0.136 0.00000023 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0426535 0.00824906 0.0000002362645 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.00097 None 0.00000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.01 0.0019 0.00000024 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0425826 0.00824908 0.0000002473875 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0435139 0.00843399 0.0000002510449 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0425075 0.00824911 0.0000002597019 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0423991 0.00823605 0.0000002667092 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Battram T ARIES None 2020-08-20 Ratio of polyunsaturated fatty acids to total fatty acids EFO_0010733, EFO_0005110 None None DNA methylation Ratio of polyunsaturated fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.063 0.0122 0.00000027 None Battram-T_ratio_of_polyunsaturated_fatty_acids_to_total_fatty_acids Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 1955 3 61 Both None cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0126963 0.0024725 0.000000282 - 28213390_serum_triglycerides_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0423422 0.00824917 0.0000002889412 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.042307 0.00824918 0.0000002955803 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.158951 0.0310104 0.0000002994234 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0435085 0.00849662 0.0000003082788 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0421831 0.00824922 0.0000003200781 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0654564 0.012811 0.0000003272425 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0433274 0.00849757 0.0000003460733 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.044751 0.00879158 0.0000003620952 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.03 0.00587 0.00000037 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0419103 0.00824932 0.0000003811425 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4851 9 54.5 Both European,South Asian cg16246545 chr1:120255941 1 120255941 PHGDH South shore -7.5 1.5 0.00000039 - 28002404_body_mass_index_all_ancestry_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0433182 0.00855101 0.0000004115128 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0446751 0.00881975 0.0000004126235 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.114603 0.0226588 0.0000004285722 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore 0.0058 0.0012 0.00000044 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0452229 0.00896057 0.0000004544722 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_4 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 South Asian ancestry discovery Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 2680 1 51.0 Both South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore -28.59 4.99 0.00000047 - 28002404_body_mass_index_south_asian_ancestry_discovery Gadd DA Generation Scotland 35945220 31/07/2022 STC2 protein levels (SeqId = 6231-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STC2 protein levels (SeqId = 6231-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stanniocalcin-2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.68 0.136 0.00000047 None Gadd-DA_stc2_protein_levels__seqid___6231-46__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.04151 0.00824946 0.0000004915255 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0451514 0.0089774 0.00000049772 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0414582 0.00824947 0.0000005078691 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0413827 0.0082495 0.0000005326566 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0414914 0.00827134 0.0000005329526 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0413652 0.0082495 0.0000005385825 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0412822 0.00824691 0.0000005628349 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0412709 0.00824954 0.0000005715442 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0412566 0.00824954 0.0000005766881 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0412463 0.00824955 0.0000005804515 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0480492 0.00961389 0.0000005862844 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0376832 0.007551 0.0000006091678 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CFHR1 protein levels (SeqId = 15468-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFHR1 protein levels (SeqId = 15468-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement factor H-related protein 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.64 0.129 0.00000061 None Gadd-DA_cfhr1_protein_levels__seqid___15468-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0412185 0.00826631 0.0000006224206 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 1 0.204 0.00000064 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.0409906 0.00824963 0.0000006813496 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0409427 0.00824965 0.0000007020302 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0409031 0.00824966 0.0000007196123 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea -0.00075 0.00015 0.00000072 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0478167 0.00965266 0.0000007361439 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0411797 0.00831335 0.0000007372312 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0480236 0.00971852 0.0000007839953 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0407021 0.00824973 0.0000008154863 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0407326 0.0082688 0.0000008481625 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0405721 0.00824977 0.0000008839791 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0434224 0.00884162 0.0000009152377 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0618688 0.0126035 0.0000009260266 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PRSS2 protein levels (SeqId = 5034-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS2 protein levels (SeqId = 5034-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trypsin-2 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.64 0.131 0.00000096 None Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0403886 0.00824983 0.000000990067 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0406338 0.00829993 0.0000009901202 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.134463 0.0274812 0.000001002554 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0444383 0.00908559 0.000001013478 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0403362 0.00824985 0.000001022554 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0403117 0.00824986 0.0000010381 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03036514 chr1:120255011 1 120255011 PHGDH Island 0.00548 0.00109 0.0000011 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 OXT protein levels (SeqId = 8356-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OXT protein levels (SeqId = 8356-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oxytocin-neurophysin 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.66 0.136 0.0000011 None Gadd-DA_oxt_protein_levels__seqid___8356-88__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.040125 0.00824992 0.000001164164 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0455411 0.00936971 0.000001183237 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Wilson LE Sister Study 30938765 2019-02-14 Alcohol Consumption EFO_0004329, EFO_0007878 replication Web Table 1 DNA methylation Alcohol Consumption Age, breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based) M Values drinks per week Illumina HumanMethylation450 Whole blood Discovery P-value not reported 187 1 Adults Females Unclear cg16246545 chr1:120255941 1 120255941 PHGDH South shore None None 0.0000012 None 30938765_Wilson-LE_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0400519 0.00824995 0.000001217429 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0439934 0.00906793 0.000001237716 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0427195 0.00881037 0.000001255018 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0411887 0.00850037 0.000001275706 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.039963 0.00824998 0.000001285415 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0398252 0.00825002 0.000001398013 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0656784 0.0136198 0.000001433624 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0409524 0.00851347 0.000001521992 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0522278 0.0108599 0.000001530262 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0396219 0.00825009 0.000001581637 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.132273 0.0275448 0.000001583089 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0391404 0.00815626 0.000001611734 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 EFS protein levels (SeqId = 12572-236) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFS protein levels (SeqId = 12572-236) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Embryonal Fyn-associated substrate 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.65 0.136 0.0000017 None Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0474442 0.0099104 0.000001706838 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0393741 0.00825017 0.000001836909 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0393631 0.00825017 0.000001849085 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.168608 0.0353413 0.000001849605 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06763568 chr1:120284868 1 120284868 PHGDH Open sea 0.00095 None 0.0000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T ARIES None 2020-08-20 Free cholesterol in large VLDL EFO_0008591 None None DNA methylation Free cholesterol in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 659 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -9.9 2.07 0.0000019 None Battram-T_free_cholesterol_in_large_vldl Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.001 None 0.0000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0393023 0.00825019 0.000001918006 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.045641 0.00958177 0.000001922673 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0430116 0.00903162 0.000001932009 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0418389 0.00878773 0.000001944277 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 CD14+ monocytes Table S7 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 CD14+ monocytes - 1251 1 60 Both European,African,Admixed cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.000474 9.9e-05 0.00000198 - 27843151_alcohol_consumption_per_day_cd14_monocytes Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11551257 chr1:120255387 1 120255387 PHGDH Island 0.0007 None 0.000002 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 ADSSL1 protein levels (SeqId = 13998-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADSSL1 protein levels (SeqId = 13998-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenylosuccinate synthetase isozyme 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.646 0.136 0.000002 None Gadd-DA_adssl1_protein_levels__seqid___13998-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0392302 0.00825022 0.000002002824 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0515234 0.0108697 0.000002156341 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 DEFB1 protein levels (SeqId = 6629-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB1 protein levels (SeqId = 6629-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.619 0.131 0.0000022 None Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.73 0.154 0.0000022 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0391437 0.00827002 0.000002230688 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0427469 0.00903933 0.000002277518 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0390025 0.00825029 0.000002295114 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.043822 0.00927161 0.000002305707 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 0.0389429 0.00825031 0.000002378218 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0440673 0.00934544 0.00000243479 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0388968 0.00825032 0.000002444368 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0402534 0.00854968 0.000002522356 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0510013 0.0108415 0.000002571298 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 DNER protein levels (SeqId = 11442-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNER protein levels (SeqId = 11442-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Delta and Notch-like epidermal growth factor-related receptor 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.64 0.136 0.0000026 None Gadd-DA_dner_protein_levels__seqid___11442-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0434412 0.00924641 0.000002648899 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0387475 0.00825037 0.000002671193 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Battram T ARIES None 2020-08-20 Ratio of monounsaturated fatty acids to total fatty acids EFO_0005110 None None DNA methylation Ratio of monounsaturated fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 669 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.057 0.0121 0.0000027 None Battram-T_ratio_of_monounsaturated_fatty_acids_to_total_fatty_acids Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0386917 0.00825039 0.000002760961 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.041405 0.00883552 0.000002808346 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.038896 0.00830224 0.000002824759 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4195 8 54.6 Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -7.09 1.52 0.0000029 - 28002404_body_mass_index_european_ancestry_replication Gomez-Alonso MDC KORA F4 33413638 2021-01-07 LAtoFA None Meta-analysis Table S2 DNA methylation LAtoFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Ratio of 18:2 linoleic acid to total fatty acids 5414 4 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.24 0.052 0.0000029 None 33413638_Gomez-Alonso-MDC_latofa_meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.106152 0.0227131 0.000002982157 None 39706196_Hannah-M.-Smith_body_fat_discovery Cardona A LOLIPOP 31506343 2019-09-10 Type II diabetes EFO_0001360 Replication in Indians Table 3 Type II diabetes DNA methylation Cell composition (reference based), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 2664 1 Adults Both South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.211 None 0.000003 None 31506343_Cardona-A_type_ii_diabetes_replication_in_indians Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -1.3 0.273 0.000003 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0486837 0.0104266 0.000003050744 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CBLN1 protein levels (SeqId = 9313-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBLN1 protein levels (SeqId = 9313-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cerebellin-1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.61 0.131 0.0000031 None Gadd-DA_cbln1_protein_levels__seqid___9313-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MARCO protein levels (SeqId = 9003-99) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MARCO protein levels (SeqId = 9003-99) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Macrophage receptor MARCO 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.63 0.136 0.0000032 None Gadd-DA_marco_protein_levels__seqid___9003-99__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0384051 0.00825048 0.000003269871 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0396559 0.00853703 0.000003427623 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0383032 0.00825051 0.000003471658 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0382983 0.00825051 0.000003481547 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0382956 0.00825051 0.000003487101 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 0.038288 0.00825052 0.000003502665 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore 0.102049 0.0220057 0.000003553062 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0422449 0.00911956 0.000003646563 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0382114 0.00825054 0.0000036635 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0382085 0.00825054 0.000003669725 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Battram T ARIES None 2020-08-20 Triglycerides EFO_0004530 fasting None DNA methylation Triglycerides Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.37 0.08 0.0000037 None Battram-T_triglycerides_fasting Battram T ARIES None 2020-08-20 VLDL cholesterol EFO_0008317 fasting None DNA methylation VLDL cholesterol Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.82 0.176 0.0000038 None Battram-T_vldl_cholesterol_fasting Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10827253 chr1:120253477 1 120253477 PHGDH North shore 0.005 0.0011 0.0000039 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0408067 0.00885174 0.000004060308 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.065466 0.014206 0.000004093289 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0390508 0.00847467 0.000004101025 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05084811 chr1:120279236 1 120279236 PHGDH Open sea 0.0379769 0.00825062 0.000004201154 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0445948 0.00969334 0.000004248771 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Battram T ARIES None 2020-08-20 Cholesterol esters in large VLDL EFO_0008589 None None DNA methylation Cholesterol esters in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 661 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -9.5 2.06 0.0000043 None Battram-T_cholesterol_esters_in_large_vldl Battram T ARIES None 2020-08-20 Total cholesterol to total lipids ratio in medium HDL EFO_0004574 None None DNA methylation Total cholesterol to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.079 0.0171 0.0000043 None Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_hdl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0392536 0.00853709 0.000004301124 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0379202 0.00825063 0.000004341853 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Karabegovic I Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK 33990564 05-14-2021 Coffee and tea consumption None Discovery Table 2 DNA methylation Coffee and tea consumption Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption Beta values None Illumina HumanMethylation450 Whole blood None 9612 7 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0011 0.0002 0.0000044 None 33990564_Karabegovic-I_coffee_and_tea_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0378814 0.00825065 0.000004441063 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea -0.0378757 0.00825065 0.000004455665 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0389335 0.00849395 0.00000460631 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0406089 0.00886116 0.000004625769 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.0377874 0.00825067 0.000004689852 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CLN5 protein levels (SeqId = 8874-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLN5 protein levels (SeqId = 8874-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ceroid-lipofuscinosis neuronal protein 5 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.62 0.136 0.0000047 None Gadd-DA_cln5_protein_levels__seqid___8874-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0571666 0.012486 0.00000472286 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0425354 0.00930177 0.000004851215 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0377129 0.0082507 0.000004896643 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADAM30 protein levels (SeqId = 8520-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAM30 protein levels (SeqId = 8520-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 30 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.62 0.136 0.0000049 None Gadd-DA_adam30_protein_levels__seqid___8520-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0376998 0.0082507 0.000004933883 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADIPOQ protein levels (SeqId = 3554-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADIPOQ protein levels (SeqId = 3554-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adiponectin 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.6 0.131 0.000005 None Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0376557 0.00825072 0.000005061164 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 OMD protein levels (SeqId = 5358-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OMD protein levels (SeqId = 5358-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Osteomodulin 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.62 0.135 0.0000051 None Gadd-DA_omd_protein_levels__seqid___5358-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 C9JB55 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation C9JB55 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0495585 0.010869 0.000005166303 C9JB55 41361833_Josephine_Robertson_C9JB55_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 FAw6toFA None Meta-analysis Table S2 DNA methylation FAw6toFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Omega-6 fatty acids 5414 4 Adults Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.2 0.044 0.0000052 None 33413638_Gomez-Alonso-MDC_faw6tofa_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 TNKS protein levels (SeqId = 9907-216) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNKS protein levels (SeqId = 9907-216) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Poly [ADP-ribose] polymerase tankyrase-1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.62 0.136 0.0000054 None Gadd-DA_tnks_protein_levels__seqid___9907-216__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CBLN1 protein levels (SeqId = 9313-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBLN1 protein levels (SeqId = 9313-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cerebellin-1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.62 0.136 0.0000055 None Gadd-DA_cbln1_protein_levels__seqid___9313-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0531558 0.0116978 0.000005561627 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0374843 0.00825077 0.000005586791 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 South Asian ancestry discovery Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 2680 1 51.0 Both South Asian cg16246545 chr1:120255941 1 120255941 PHGDH South shore -20.56 3.99 0.0000057 - 28002404_body_mass_index_south_asian_ancestry_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0374299 0.00825079 0.000005764117 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ASGR1 protein levels (SeqId = 5452-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASGR1 protein levels (SeqId = 5452-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Asialoglycoprotein receptor 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.62 0.136 0.0000058 None Gadd-DA_asgr1_protein_levels__seqid___5452-71__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0446598 0.00985673 0.000005919936 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ADSSL1 protein levels (SeqId = 13998-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADSSL1 protein levels (SeqId = 13998-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenylosuccinate synthetase isozyme 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.592 0.131 0.000006 None Gadd-DA_adssl1_protein_levels__seqid___13998-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MASP1 protein levels (SeqId = 9125-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MASP1 protein levels (SeqId = 9125-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mannan-binding lectin serine protease 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.61 0.136 0.000006 None Gadd-DA_masp1_protein_levels__seqid___9125-23__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -1.100593 0.2436 0.00000625 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0372567 0.00825084 0.000006365916 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 IL36B protein levels (SeqId = 14149-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL36B protein levels (SeqId = 14149-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-36 beta 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.61 0.136 0.0000064 None Gadd-DA_il36b_protein_levels__seqid___14149-9__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.138565 0.0307069 0.000006448892 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0372246 0.00825085 0.000006483803 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0372085 0.00825085 0.000006543815 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Replication Table 2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 719 1 67.5 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.017 0.003 0.0000067 - 28624579_gammaglutamyl_transferase_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0527464 0.0117201 0.000006830876 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0403042 0.00896024 0.000006908783 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0385752 0.00858037 0.00000698568 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.0383092 0.00852602 0.000007069516 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0406902 0.0090577 0.000007098799 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0380416 0.00847794 0.000007273884 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0525618 0.0117226 0.000007388426 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0395426 0.00882095 0.000007422666 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore 0.0385721 0.00861569 0.000007628527 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.120034 0.0268141 0.000007633124 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0440535 0.00984049 0.0000076356 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 GSTA1 protein levels (SeqId = 17138-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSTA1 protein levels (SeqId = 17138-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione S-transferase A1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.61 0.136 0.0000077 None Gadd-DA_gsta1_protein_levels__seqid___17138-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.037579 0.00840211 0.000007786466 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 African ancestry Table S6 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 Whole blood - 2423 3 56 Both African cg14476101 chr1:120255992 1 120255992 PHGDH South shore -7.87e-05 1.76e-05 0.00000811 - 27843151_alcohol_consumption_per_day_african_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0368149 0.00825097 0.000008184807 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg03036514 chr1:120255011 1 120255011 PHGDH Island 0.135453 0.0303861 0.000008333044 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Battram T ARIES None 2020-08-20 Serum total triglycerides EFO_0004530 None None DNA methylation Serum total triglycerides Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.33 0.074 0.0000084 None Battram-T_serum_total_triglycerides Gadd DA Generation Scotland 35945220 31/07/2022 ART4 protein levels (SeqId = 6576-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ART4 protein levels (SeqId = 6576-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ecto-ADP-ribosyltransferase 4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.0000087 None Gadd-DA_art4_protein_levels__seqid___6576-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.0366815 0.00825101 0.000008824891 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0366697 0.00825102 0.000008883822 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0379404 0.00853719 0.000008889244 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0366685 0.00825102 0.000008889816 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0366674 0.00825102 0.000008895441 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.036586 0.00825104 0.000009312492 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Juvinao-Quintero DL ALSPAC, LBC1936, RSIII-1, RS-Bios 33622391 2021-02-23 Type 2 diabetes EFO_0001360 meta-analysis Table 2 DNA methylation Type 2 diabetes age, sex, batch effects, cell composition (reference based), smoking Beta Values None Illumina HumanMethylation450 Whole blood None 3428 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.015 0.00336 0.0000095 None 33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.323341 0.073 0.0000095 - 27105112_hiv_infection_neutrophils Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0365502 0.00825105 0.000009502048 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0518154 0.0116982 0.000009520358 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.042918 0.00968947 0.000009520577 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0365437 0.00825106 0.00000953703 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Battram T ARIES None 2020-08-20 Free cholesterol to total lipids ratio in IDL EFO_0008591 None None DNA methylation Free cholesterol to total lipids ratio in IDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 674 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.196 0.044 0.0000096 None Battram-T_free_cholesterol_to_total_lipids_ratio_in_idl Gadd DA Generation Scotland 35945220 31/07/2022 PRSS2 protein levels (SeqId = 5034-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS2 protein levels (SeqId = 5034-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trypsin-2 774 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.68 0.154 0.0000097 None Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPACA1 protein levels (SeqId = 6228-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPACA1 protein levels (SeqId = 6228-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sperm acrosome membrane-associated protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.0000097 None Gadd-DA_spaca1_protein_levels__seqid___6228-58__somascan_protein_measurement Battram T ARIES None 2020-08-20 Triglycerides in large VLDL EFO_0004530 None None DNA methylation Triglycerides in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 670 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -1.76 0.39 0.0000098 None Battram-T_triglycerides_in_large_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea -0.0364889 0.00825107 0.000009834913 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0364818 0.00825108 0.000009874341 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.0374432 0.00846947 0.00000989709 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Battram T ARIES None 2020-08-20 Free cholesterol in medium VLDL EFO_0008591 None None DNA methylation Free cholesterol in medium VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 675 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -4.9 1.09 0.00001 None Battram-T_free_cholesterol_in_medium_vldl Battram T ARIES None 2020-08-20 Total cholesterol in large VLDL EFO_0004574 None None DNA methylation Total cholesterol in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 664 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -4.7 1.06 0.00001 None Battram-T_total_cholesterol_in_large_vldl Gadd DA Generation Scotland 35945220 31/07/2022 RAMP1 protein levels (SeqId = 15436-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAMP1 protein levels (SeqId = 15436-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor activity-modifying protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.00001 None Gadd-DA_ramp1_protein_levels__seqid___15436-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBP4 protein levels (SeqId = 15633-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP4 protein levels (SeqId = 15633-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.00001 None Gadd-DA_rbp4_protein_levels__seqid___15633-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0363914 0.0082511 0.00001038719 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0478597 0.0108545 0.00001044829 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 C9JB55 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation C9JB55 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0479188 0.0108838 0.00001076293 C9JB55 41361833_Josephine_Robertson_C9JB55_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0363225 0.00825112 0.00001079511 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0363184 0.00825112 0.00001082018 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0561137 0.0127557 0.00001094698 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Jiantao Ma RS, MESA, CARDIA 30796027 Feb 22, 2019 hepatic fat EFO_0010821 Replication Table 1 DNA methylation hepatic fat Age, Sex, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylation450 whole blood None 1904 3 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000011 None 30796027_Jiantao-Ma_hepatic_fat_replication Battram T ARIES None 2020-08-20 Phospholipids in small VLDL EFO_0004639 None None DNA methylation Phospholipids in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -3.4 0.78 0.000011 None Battram-T_phospholipids_in_small_vldl Gadd DA Generation Scotland 35945220 31/07/2022 SLAMF6 protein levels (SeqId = 5128-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLAMF6 protein levels (SeqId = 5128-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SLAM family member 6 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.000011 None Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH2 protein levels (SeqId = 18381-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH2 protein levels (SeqId = 18381-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldehyde dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.6 0.136 0.000011 None Gadd-DA_aldh2_protein_levels__seqid___18381-16__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0394965 0.00898983 0.00001123405 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0513146 0.0116823 0.00001128447 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0405364 0.00924671 0.00001174007 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0529734 0.0120863 0.00001179183 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0387861 0.00885026 0.00001181493 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0361541 0.00825117 0.00001185812 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Battram T ARIES None 2020-08-20 Cholesterol esters to total lipids ratio in medium HDL EFO_0008589 None None DNA methylation Cholesterol esters to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.075 0.017 0.000012 None Battram-T_cholesterol_esters_to_total_lipids_ratio_in_medium_hdl Battram T ARIES None 2020-08-20 Glycoprotein acetyls EFO_0004555 None None DNA methylation Glycoprotein acetyls Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.96 0.22 0.000012 None Battram-T_glycoprotein_acetyls Gadd DA Generation Scotland 35945220 31/07/2022 FTL protein levels (SeqId = 15324-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTL protein levels (SeqId = 15324-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin light chain 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.59 0.136 0.000012 None Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0362058 0.00827384 0.00001217481 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.140728 0.0321896 0.00001239227 None 39706196_Hannah-M.-Smith_bmi_discovery Battram T ARIES None 2020-08-20 Triglycerides in VLDL EFO_0004530 None None DNA methylation Triglycerides in VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 677 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.39 0.088 0.000013 None Battram-T_triglycerides_in_vldl Gadd DA Generation Scotland 35945220 31/07/2022 ACY1 protein levels (SeqId = 3343-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACY1 protein levels (SeqId = 3343-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aminoacylase-1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.57 0.131 0.000013 None Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFS protein levels (SeqId = 12572-236) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFS protein levels (SeqId = 12572-236) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Embryonal Fyn-associated substrate 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.57 0.131 0.000013 None Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement Battram T ARIES None 2020-08-20 Triglycerides in medium VLDL EFO_0004530 None None DNA methylation Triglycerides in medium VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 673 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -1.12 0.256 0.000013 None Battram-T_triglycerides_in_medium_vldl Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0052 None 0.000013 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0359639 0.00825123 0.00001317836 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0380252 0.00872421 0.00001317959 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0380576 0.00873488 0.00001327745 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0410883 0.00945474 0.00001397087 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Battram T ARIES None 2020-08-20 Triglycerides in small HDL EFO_0004530 None None DNA methylation Triglycerides in small HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -10.8 2.5 0.000014 None Battram-T_triglycerides_in_small_hdl Gadd DA Generation Scotland 35945220 31/07/2022 PRSS2 protein levels (SeqId = 5034-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS2 protein levels (SeqId = 5034-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trypsin-2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.59 0.136 0.000014 None Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.59 0.136 0.000014 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg21941299 chr1:120281896 1 120281896 PHGDH Open sea 0.034 0.00783 0.000014 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0598118 0.0137668 0.00001404432 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0396895 0.00913814 0.00001413137 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.038166 0.00879036 0.00001422673 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0347991 0.00802284 0.00001450757 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0357652 0.00825129 0.0000147065 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 OXT protein levels (SeqId = 8356-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OXT protein levels (SeqId = 8356-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oxytocin-neurophysin 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.56 0.131 0.000015 None Gadd-DA_oxt_protein_levels__seqid___8356-88__somascan_protein_measurement Cardona A FHS 31506343 2019-09-10 Type II diabetes EFO_0001360 Replication in Europeans Table 3 DNA methylation Type II diabetes Age, sex, cell composition (reference based), batch effects, body mass index Beta Values None Illumina HumanMethylation450 Whole blood None 2607 1 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.016 0.0036 0.000015 None 31506343_Cardona-A_type_ii_diabetes_replication_in_europeans Gadd DA Generation Scotland 35945220 31/07/2022 SPACA5 protein levels (SeqId = 6494-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPACA5 protein levels (SeqId = 6494-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sperm acrosome-associated protein 5 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.587 0.136 0.000015 None Gadd-DA_spaca5_protein_levels__seqid___6494-60__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0357267 0.0082513 0.00001502206 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0358265 0.00827633 0.00001509206 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.138323 0.0319726 0.00001524861 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.039786 0.0091981 0.00001532236 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0506045 0.0117193 0.00001584457 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0356264 0.00825133 0.00001587291 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11551257 chr1:120255387 1 120255387 PHGDH Island 0.00098 0.00023 0.000016 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Battram T ARIES None 2020-08-20 Triglycerides to total lipids ratio in medium HDL EFO_0004530 None None DNA methylation Triglycerides to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.115 0.026 0.000016 None Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl Battram T ARIES None 2020-08-20 Concentration of large VLDL particles EFO_0008317 None None DNA methylation Concentration of large VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 670 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -62000000 14000000 0.000016 None Battram-T_concentration_of_large_vldl_particles Gadd DA Generation Scotland 35945220 31/07/2022 STAP1 protein levels (SeqId = 12510-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAP1 protein levels (SeqId = 12510-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal-transducing adaptor protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.59 0.14 0.000016 None Gadd-DA_stap1_protein_levels__seqid___12510-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C2orf66 protein levels (SeqId = 5677-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C2orf66 protein levels (SeqId = 5677-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C2orf66 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.59 0.136 0.000016 None Gadd-DA_c2orf66_protein_levels__seqid___5677-15__somascan_protein_measurement Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore - - 0.0000167 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0422667 0.0098197 0.00001686219 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_4 Battram T ARIES None 2020-08-20 Free cholesterol in small VLDL EFO_0008591 None None DNA methylation Free cholesterol in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -5 1.15 0.000017 None Battram-T_free_cholesterol_in_small_vldl Colicino E CHARGE 32697766 07-22-2020 All cause mortality EFO_0004352 basic model Table S2 All cause mortality DNA methylation Age, Sex, Cell composition (reference based), Batch effects None M values Illumina HumanMethylation450 Whole blood Effect estimates represent hazard ratio per 10% increase in DNA methylation. 12300 12 Adults Both European, African cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.93 None 0.000017 None 32697766_Colicino-E_all_cause_mortality_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0504671 0.0117309 0.00001703016 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0379957 0.00884178 0.00001740137 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0354436 0.00825138 0.00001754451 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SCIMP protein levels (SeqId = 10510-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCIMP protein levels (SeqId = 10510-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SLP adapter and CSK-interacting membrane protein 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.58 0.136 0.000018 None Gadd-DA_scimp_protein_levels__seqid___10510-62__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 1.1 0.256 0.000018 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.046581 0.0108623 0.0000181184 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0410846 0.0095848 0.00001827296 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0353159 0.00825142 0.00001880971 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0379178 0.00886008 0.00001883954 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Battram T ARIES None 2020-08-20 Phospholipids in large VLDL EFO_0004639 None None DNA methylation Phospholipids in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 669 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -5.7 1.31 0.000019 None Battram-T_phospholipids_in_large_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0419828 0.00982657 0.00001946208 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.0352225 0.00825145 0.00001978962 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18059 1 Adults (18-65y) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.058 0.0135 0.00002 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 YIPF6 protein levels (SeqId = 9984-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 YIPF6 protein levels (SeqId = 9984-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein YIPF6 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.58 0.136 0.00002 None Gadd-DA_yipf6_protein_levels__seqid___9984-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0415626 0.00974718 0.00002020034 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0383345 0.00899733 0.00002051031 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0351552 0.00825147 0.00002052636 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ALDOB protein levels (SeqId = 18185-118) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOB protein levels (SeqId = 18185-118) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase B 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.55 0.13 0.000021 None Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ENGASE protein levels (SeqId = 16781-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ENGASE protein levels (SeqId = 16781-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytosolic endo-beta-N-acetylglucosaminidase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.577 0.136 0.000021 None Gadd-DA_engase_protein_levels__seqid___16781-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0350651 0.00825149 0.00002155287 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0393024 0.00925453 0.00002181582 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 FTL protein levels (SeqId = 15324-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTL protein levels (SeqId = 15324-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin light chain 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.55 0.131 0.000022 None Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.55 0.131 0.000022 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0530144 0.0124991 0.00002234272 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0349665 0.00825152 0.00002273242 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03373466 chr1:120254222 1 120254222 PHGDH North shore -0.107418 0.0253566 0.00002284003 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0349535 0.00825153 0.00002289213 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0373806 0.00882487 0.00002291056 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Battram T ARIES None 2020-08-20 Concentration of medium VLDL particles EFO_0008317 None None DNA methylation Concentration of medium VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -20000000 None 0.000023 None Battram-T_concentration_of_medium_vldl_particles Gadd DA Generation Scotland 35945220 31/07/2022 RSPO4 protein levels (SeqId = 8464-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RSPO4 protein levels (SeqId = 8464-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: R-spondin-4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.58 0.14 0.000023 None Gadd-DA_rspo4_protein_levels__seqid___8464-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPINK14 protein levels (SeqId = 8587-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPINK14 protein levels (SeqId = 8587-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine protease inhibitor Kazal-type 14 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.14 0.000023 None Gadd-DA_spink14_protein_levels__seqid___8587-21__somascan_protein_measurement Battram T ARIES None 2020-08-20 Phospholipids in medium VLDL EFO_0004639 None None DNA methylation Phospholipids in medium VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -3 0.71 0.000024 None Battram-T_phospholipids_in_medium_vldl Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.006 0.0014 0.000024 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.78 0.185 0.000024 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Gadd DA Generation Scotland 35945220 31/07/2022 VWC2L protein levels (SeqId = 7995-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VWC2L protein levels (SeqId = 7995-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: von Willebrand factor C domain-containing protein 2-like 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.136 0.000024 None Gadd-DA_vwc2l_protein_levels__seqid___7995-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GDNF protein levels (SeqId = 5822-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDNF protein levels (SeqId = 5822-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glial cell line-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.136 0.000024 None Gadd-DA_gdnf_protein_levels__seqid___5822-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KLRK1 protein levels (SeqId = 14095-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLRK1 protein levels (SeqId = 14095-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NKG2-D type II integral membrane protein 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.136 0.000024 None Gadd-DA_klrk1_protein_levels__seqid___14095-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0541253 0.012817 0.00002426007 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0347924 0.00825157 0.00002496595 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Battram T ARIES None 2020-08-20 Triglycerides in medium HDL EFO_0004530 None None DNA methylation Triglycerides in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -10.3 2.4 0.000025 None Battram-T_triglycerides_in_medium_hdl Battram T ARIES None 2020-08-20 Total lipids in large VLDL EFO_0004529 None None DNA methylation Total lipids in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -1.01 0.237 0.000025 None Battram-T_total_lipids_in_large_vldl Gadd DA Generation Scotland 35945220 31/07/2022 POTEG protein levels (SeqId = 7960-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POTEG protein levels (SeqId = 7960-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: POTE ankyrin domain family member G 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.136 0.000025 None Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0389899 0.00925096 0.00002516288 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Battram T ARIES None 2020-08-20 Total lipids in medium VLDL EFO_0004529 None None DNA methylation Total lipids in medium VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.58 0.138 0.000026 None Battram-T_total_lipids_in_medium_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0392191 0.00932615 0.00002623119 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0381771 0.00909076 0.00002690301 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0492083 0.011718 0.00002692284 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 RBP5 protein levels (SeqId = 19241-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP5 protein levels (SeqId = 19241-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 5 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.55 0.13 0.000027 None Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZNF566 protein levels (SeqId = 12795-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF566 protein levels (SeqId = 12795-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 566 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.57 0.136 0.000028 None Gadd-DA_znf566_protein_levels__seqid___12795-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRLF2 protein levels (SeqId = 13694-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRLF2 protein levels (SeqId = 13694-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytokine receptor-like factor 2 774 1 Adults (18-65 years) Both European cg07874730 chr1:120281395 1 120281395 PHGDH Open sea 0.98 0.234 0.000028 None Gadd-DA_crlf2_protein_levels__seqid___13694-24__somascan_protein_measurement Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.69 0.17 0.000029 4806 31197173_Liu-J_fasting_glucose_base Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0399971 0.00957122 0.00002946291 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0344213 0.00825168 0.00003044339 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04139379 chr1:120261921 1 120261921 PHGDH Open sea -0.0343382 0.0082517 0.00003181735 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.034311 0.00825171 0.00003228063 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ASL protein levels (SeqId = 11241-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASL protein levels (SeqId = 11241-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Argininosuccinate lyase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.135 0.000033 None Gadd-DA_asl_protein_levels__seqid___11241-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0342614 0.00825172 0.00003314071 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0366959 0.00883948 0.00003323705 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06763568 chr1:120284868 1 120284868 PHGDH Open sea -0.0042 0.001 0.000034 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 TMED4 protein levels (SeqId = 9319-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMED4 protein levels (SeqId = 9319-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane emp24 domain-containing protein 4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000034 None Gadd-DA_tmed4_protein_levels__seqid___9319-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HRSP12 protein levels (SeqId = 14636-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HRSP12 protein levels (SeqId = 14636-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 2-iminobutanoate/2-iminopropanoate deaminase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000034 None Gadd-DA_hrsp12_protein_levels__seqid___14636-25__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0342058 0.00825174 0.00003413081 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.034192 0.00825174 0.00003437939 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SULT2A1 protein levels (SeqId = 9829-91) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SULT2A1 protein levels (SeqId = 9829-91) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bile salt sulfotransferase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.135 0.000035 None Gadd-DA_sult2a1_protein_levels__seqid___9829-91__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.0341098 0.00825177 0.00003590529 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.133246 0.0322653 0.00003649401 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.044675 0.0108227 0.00003681252 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CD5L protein levels (SeqId = 3293-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD5L protein levels (SeqId = 3293-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CD5 antigen-like 774 1 Adults (18-65 years) Both European cg07477090 chr1:120255318 1 120255318 PHGDH Island -0.68 0.164 0.000037 None Gadd-DA_cd5l_protein_levels__seqid___3293-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GSTA1 protein levels (SeqId = 17138-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSTA1 protein levels (SeqId = 17138-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione S-transferase A1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.54 0.13 0.000037 None Gadd-DA_gsta1_protein_levels__seqid___17138-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBP4 protein levels (SeqId = 15633-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP4 protein levels (SeqId = 15633-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 4 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.54 0.131 0.000037 None Gadd-DA_rbp4_protein_levels__seqid___15633-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CFHR1 protein levels (SeqId = 15468-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFHR1 protein levels (SeqId = 15468-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement factor H-related protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.134 0.000037 None Gadd-DA_cfhr1_protein_levels__seqid___15468-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.034034 0.00825179 0.00003736898 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0340282 0.00825179 0.00003748262 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GAGE2D protein levels (SeqId = 18273-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAGE2D protein levels (SeqId = 18273-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: G antigen 2D 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000038 None Gadd-DA_gage2d_protein_levels__seqid___18273-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0339725 0.00825181 0.00003859704 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0067 0.0016 0.000039 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 SLAMF8 protein levels (SeqId = 8994-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLAMF8 protein levels (SeqId = 8994-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SLAM family member 8 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000039 None Gadd-DA_slamf8_protein_levels__seqid___8994-65__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0445321 0.0108286 0.00003936389 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.000349 8.46e-05 0.0000397 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.00332 0.00081 0.00004 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0358499 0.00873026 0.00004040654 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 STOM protein levels (SeqId = 8261-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STOM protein levels (SeqId = 8261-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Erythrocyte band 7 integral membrane protein 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.556 0.136 0.000041 None Gadd-DA_stom_protein_levels__seqid___8261-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0377958 0.00922283 0.00004188486 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 EGLN1 protein levels (SeqId = 9901-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EGLN1 protein levels (SeqId = 9901-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Egl nine homolog 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000042 None Gadd-DA_egln1_protein_levels__seqid___9901-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITPKC protein levels (SeqId = 12507-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITPKC protein levels (SeqId = 12507-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inositol-trisphosphate 3-kinase C 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000042 None Gadd-DA_itpkc_protein_levels__seqid___12507-16__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKR7A3 protein levels (SeqId = 18173-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR7A3 protein levels (SeqId = 18173-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aflatoxin B1 aldehyde reductase member 3 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000042 None Gadd-DA_akr7a3_protein_levels__seqid___18173-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0338021 0.00825185 0.00004220632 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Huang D BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY 32520614 2020-11-12 Systolic Blood Pressure EFO_0006335 Discovery Table 2, table 3 DNA methylation Systolic Blood Pressure age, sex, ancestry, body mass index, cell composition (reference based) Beta Values mmHg Illumina HumanMethylation450 Whole blood Includes some twins 4820 15 Adults Both European, Admixed cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000043 None 32520614_Huang-D_systolic_blood_pressure_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ADI1 protein levels (SeqId = 12457-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADI1 protein levels (SeqId = 12457-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.56 0.136 0.000043 None Gadd-DA_adi1_protein_levels__seqid___12457-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBP5 protein levels (SeqId = 19241-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP5 protein levels (SeqId = 19241-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 5 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.135 0.000043 None Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0349059 0.00854143 0.00004399626 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Battram T ARIES None 2020-08-20 Triglycerides in small VLDL EFO_0004530 None None DNA methylation Triglycerides in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 680 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -1.52 0.37 0.000044 None Battram-T_triglycerides_in_small_vldl Gadd DA Generation Scotland 35945220 31/07/2022 ACY1 protein levels (SeqId = 3343-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACY1 protein levels (SeqId = 3343-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aminoacylase-1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000044 None Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea 0.0397935 0.00973775 0.00004402186 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0377822 0.00925611 0.00004491312 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 ADIPOQ protein levels (SeqId = 3554-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADIPOQ protein levels (SeqId = 3554-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adiponectin 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.55 0.136 0.000045 None Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0441462 0.010826 0.00004570713 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.029 0.00711 0.000046 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg07090813 chr1:120254330 1 120254330 PHGDH North shore 0.0097 0.0023 0.000047 None 34427971_Tan-Q_age_discovery Gadd DA Generation Scotland 35945220 31/07/2022 FCER2 protein levels (SeqId = 3291-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCER2 protein levels (SeqId = 3291-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin epsilon Fc receptor 774 1 Adults (18-65 years) Both European cg07477090 chr1:120255318 1 120255318 PHGDH Island -0.67 0.164 0.000047 None Gadd-DA_fcer2_protein_levels__seqid___3291-30__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FBP1 protein levels (SeqId = 7206-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FBP1 protein levels (SeqId = 7206-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-1,6-bisphosphatase 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.53 0.13 0.000047 None Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.0397887 0.00977513 0.00004717749 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0344273 0.00845818 0.00004719849 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore -0.0359341 0.00882897 0.00004725467 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea 0.0335837 0.00825191 0.00004729764 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Battram T ARIES None 2020-08-20 Monounsaturated fatty acids 16:1 18:1 EFO_0005110 None None DNA methylation Monounsaturated fatty acids 16:1 18:1 Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 667 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.195 0.048 0.000048 None Battram-T_monounsaturated_fatty_acids_16_1_18_1 Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.63 0.154 0.000048 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea -0.0335401 0.00825193 0.0000483831 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea 0.0345113 0.00849324 0.00004861824 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Battram T ARIES None 2020-08-20 Triglycerides to total lipids ratio in small VLDL EFO_0004530 None None DNA methylation Triglycerides to total lipids ratio in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 681 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.029 0.0071 0.000049 None Battram-T_triglycerides_to_total_lipids_ratio_in_small_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0334741 0.00825194 0.00005006926 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.150013 0.0369833 0.00005009057 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24846296 chr1:120267520 1 120267520 PHGDH Open sea -0.111357 0.0274657 0.00005048645 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ZNF843 protein levels (SeqId = 8321-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF843 protein levels (SeqId = 8321-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 843 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000051 None Gadd-DA_znf843_protein_levels__seqid___8321-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADAM10 protein levels (SeqId = 8654-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAM10 protein levels (SeqId = 8654-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 10 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000051 None Gadd-DA_adam10_protein_levels__seqid___8654-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GSN protein levels (SeqId = 16607-78) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSN protein levels (SeqId = 16607-78) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gelsolin 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.55 0.136 0.000051 None Gadd-DA_gsn_protein_levels__seqid___16607-78__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 POLE2 protein levels (SeqId = 11562-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POLE2 protein levels (SeqId = 11562-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA polymerase epsilon subunit 2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.549 0.136 0.000051 None Gadd-DA_pole2_protein_levels__seqid___11562-9__somascan_protein_measurement Battram T ARIES None 2020-08-20 Concentration of small VLDL particles EFO_0008317 None None DNA methylation Concentration of small VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 681 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -14000000 None 0.000053 None Battram-T_concentration_of_small_vldl_particles Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0333362 0.00825198 0.00005377303 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0333328 0.00825198 0.00005386689 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore 0.0332865 0.008252 0.00005517003 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05084811 chr1:120279236 1 120279236 PHGDH Open sea 0.0332615 0.008252 0.00005588888 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Battram T ARIES None 2020-08-20 Free cholesterol to total lipids ratio in large VLDL EFO_0008591 None None DNA methylation Free cholesterol to total lipids ratio in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.036 0.0089 0.000056 None Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_vldl Gadd DA Generation Scotland 35945220 31/07/2022 PDXK protein levels (SeqId = 11098-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDXK protein levels (SeqId = 11098-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyridoxal kinase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000056 None Gadd-DA_pdxk_protein_levels__seqid___11098-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL17D protein levels (SeqId = 4136-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL17D protein levels (SeqId = 4136-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-17D 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.547 0.136 0.000056 None Gadd-DA_il17d_protein_levels__seqid___4136-40__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0332537 0.00825201 0.00005611302 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0437263 0.0108564 0.00005660716 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 B3GALT2 protein levels (SeqId = 11638-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B3GALT2 protein levels (SeqId = 11638-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,3-galactosyltransferase 2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000057 None Gadd-DA_b3galt2_protein_levels__seqid___11638-42__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CES1 protein levels (SeqId = 15487-164) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CES1 protein levels (SeqId = 15487-164) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Liver carboxylesterase 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.55 0.136 0.000057 None Gadd-DA_ces1_protein_levels__seqid___15487-164__somascan_protein_measurement Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 African ancestry Table S6 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 Whole blood - 2423 3 56 Both African cg16246545 chr1:120255941 1 120255941 PHGDH South shore -5.62e-05 1.4e-05 0.0000572 - 27843151_alcohol_consumption_per_day_african_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf -0.0332147 0.00825202 0.00005725279 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.0331593 0.00824039 0.00005750503 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0331708 0.00825203 0.00005856108 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0331694 0.00825203 0.00005860156 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.037446 0.0093194 0.00005896932 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore 0.019 0.00466 0.000059 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07090813 chr1:120254330 1 120254330 PHGDH North shore -0.033441 0.008326 0.00005937609 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea -0.0354121 0.00881828 0.00005954861 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07874730 chr1:120281395 1 120281395 PHGDH Open sea 0.214161 0.0533383 0.00005966126 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0361324 0.00900669 0.00006057572 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 BLNK protein levels (SeqId = 19225-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BLNK protein levels (SeqId = 19225-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: B-cell linker protein 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000061 None Gadd-DA_blnk_protein_levels__seqid___19225-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 JPH4 protein levels (SeqId = 9111-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 JPH4 protein levels (SeqId = 9111-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Junctophilin-4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000061 None Gadd-DA_jph4_protein_levels__seqid___9111-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 S100A13 protein levels (SeqId = 7223-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 S100A13 protein levels (SeqId = 7223-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein S100-A13 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.52 0.131 0.000062 None Gadd-DA_s100a13_protein_levels__seqid___7223-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYZAP protein levels (SeqId = 9055-81) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYZAP protein levels (SeqId = 9055-81) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myocardial zonula adherens protein 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.544 0.136 0.000062 None Gadd-DA_myzap_protein_levels__seqid___9055-81__somascan_protein_measurement Battram T ARIES None 2020-08-20 Total cholesterol in medium VLDL EFO_0004574 None None DNA methylation Total cholesterol in medium VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 675 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -2.07 0.51 0.000063 None Battram-T_total_cholesterol_in_medium_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19096424 chr1:120255104 1 120255104 PHGDH Island 0.0330066 0.00825207 0.00006370935 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PLCG1 protein levels (SeqId = 4563-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLCG1 protein levels (SeqId = 4563-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000064 None Gadd-DA_plcg1_protein_levels__seqid___4563-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBM23 protein levels (SeqId = 11590-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBM23 protein levels (SeqId = 11590-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable RNA-binding protein 23 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.14 0.000064 None Gadd-DA_rbm23_protein_levels__seqid___11590-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.032984 0.00825208 0.00006444977 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0340593 0.00852268 0.0000646512 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 RRAS2 protein levels (SeqId = 12361-102) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RRAS2 protein levels (SeqId = 12361-102) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related protein R-Ras2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000065 None Gadd-DA_rras2_protein_levels__seqid___12361-102__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADAMTS15 protein levels (SeqId = 4533-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAMTS15 protein levels (SeqId = 4533-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: A disintegrin and metalloproteinase with thrombospondin motifs 15 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000065 None Gadd-DA_adamts15_protein_levels__seqid___4533-76__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.0338711 0.00848808 0.00006627214 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 INSL6 protein levels (SeqId = 5754-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 INSL6 protein levels (SeqId = 5754-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like peptide INSL6 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.14 0.000067 None Gadd-DA_insl6_protein_levels__seqid___5754-76__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.0329064 0.0082521 0.00006705917 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.0329038 0.0082521 0.00006714611 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0329016 0.0082521 0.00006722374 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore 0.0328518 0.00825211 0.00006895133 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 QPCT protein levels (SeqId = 7849-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QPCT protein levels (SeqId = 7849-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaminyl-peptide cyclotransferase 774 1 Adults (18-65 years) Both European cg04086443 chr1:120286814 1 120286814 PHGDH Open sea -0.67 0.168 0.00007 None Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TLR1 protein levels (SeqId = 11149-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TLR1 protein levels (SeqId = 11149-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Toll-like receptor 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.00007 None Gadd-DA_tlr1_protein_levels__seqid___11149-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0369094 0.00928202 0.00007028976 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea 0.0428361 0.010775 0.00007056115 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore 0.0341463 0.0085914 0.00007087103 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 ALKBH2 protein levels (SeqId = 18400-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALKBH2 protein levels (SeqId = 18400-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA oxidative demethylase ALKBH2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000072 None Gadd-DA_alkbh2_protein_levels__seqid___18400-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 POTEG protein levels (SeqId = 7960-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POTEG protein levels (SeqId = 7960-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: POTE ankyrin domain family member G 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.52 0.131 0.000073 None Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.032412 0.00817904 0.00007442396 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0326133 0.00825218 0.00007783798 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg04857033 chr1:120258412 1 120258412 PHGDH South shelf 0.00308 0.00078 0.000078 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Gadd DA Generation Scotland 35945220 31/07/2022 POR protein levels (SeqId = 2731-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POR protein levels (SeqId = 2731-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADPH--cytochrome P450 reductase 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.54 0.136 0.000078 None Gadd-DA_por_protein_levels__seqid___2731-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22389654 chr1:120273819 1 120273819 PHGDH Open sea 0.0325884 0.00825219 0.00007882551 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0324793 0.00822782 0.00007934112 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SCARB2 protein levels (SeqId = 5100-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCARB2 protein levels (SeqId = 5100-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysosome membrane protein 2 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000083 None Gadd-DA_scarb2_protein_levels__seqid___5100-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.0325448 0.00826795 0.00008314369 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Nicolas Fragoso-Bargas EPIPREG 36534481 Dec 19, 2022 HOMA-IR EFO:0000001 discovery Supplementary Table 2 DNA methylation HOMA-IR Smoking,Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood analysis in pregnancy (cross ancestry) 456 1 Adults (18-65 years) Females European,South Asian cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.087628351 0.022063527 0.0000832 None 36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore 0.0324684 0.00825222 0.00008375265 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SPACA1 protein levels (SeqId = 6228-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPACA1 protein levels (SeqId = 6228-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sperm acrosome membrane-associated protein 1 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.51 0.131 0.000084 None Gadd-DA_spaca1_protein_levels__seqid___6228-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PC protein levels (SeqId = 13990-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PC protein levels (SeqId = 13990-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyruvate carboxylase, mitochondrial 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000084 None Gadd-DA_pc_protein_levels__seqid___13990-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSTPIP1 protein levels (SeqId = 19168-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSTPIP1 protein levels (SeqId = 19168-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proline-serine-threonine phosphatase-interacting protein 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000084 None Gadd-DA_pstpip1_protein_levels__seqid___19168-71__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRISP2 protein levels (SeqId = 9282-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRISP2 protein levels (SeqId = 9282-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cysteine-rich secretory protein 2 774 1 Adults (18-65 years) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore -0.53 0.135 0.000084 None Gadd-DA_crisp2_protein_levels__seqid___9282-12__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore 0.032459 0.00825222 0.0000841504 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13345849 chr1:120254570 1 120254570 PHGDH North shore -0.0342697 0.00872099 0.00008549219 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore 0.03341 0.00850335 0.00008567544 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 IGFBP4 protein levels (SeqId = 2950-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGFBP4 protein levels (SeqId = 2950-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like growth factor-binding protein 4 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.51 0.13 0.000086 None Gadd-DA_igfbp4_protein_levels__seqid___2950-57__somascan_protein_measurement Battram T ARIES None 2020-08-20 Triglycerides in HDL EFO_0004530 None None DNA methylation Triglycerides in HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -3.9 1 0.000086 None Battram-T_triglycerides_in_hdl Gadd DA Generation Scotland 35945220 31/07/2022 KLB protein levels (SeqId = 19557-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLB protein levels (SeqId = 19557-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-klotho 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.511 0.13 0.000086 None Gadd-DA_klb_protein_levels__seqid___19557-3__somascan_protein_measurement Battram T ARIES None 2020-08-20 Cholesterol esters in chylomicrons and extremely large VLDL EFO_0008589 None None DNA methylation Cholesterol esters in chylomicrons and extremely large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 651 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -94 24 0.000087 None Battram-T_cholesterol_esters_in_chylomicrons_and_extremely_large_vldl Gadd DA Generation Scotland 35945220 31/07/2022 IRF9 protein levels (SeqId = 12439-67) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IRF9 protein levels (SeqId = 12439-67) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon regulatory factor 9 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000087 None Gadd-DA_irf9_protein_levels__seqid___12439-67__somascan_protein_measurement Anna Ulrich None 38184627 Dec 5, 2023 Idiopathic/heritable pulmonary arterial hypertension None Discovery None DNA methylation Idiopathic/heritable pulmonary arterial hypertension Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes Beta values None Illumina HumanMethylationEPIC whole blood None 1655 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -11 2.8 0.000088 None 38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery Gadd DA Generation Scotland 35945220 31/07/2022 APOC3 protein levels (SeqId = 6461-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOC3 protein levels (SeqId = 6461-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein C-III 774 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.51 0.131 0.000088 None Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MSN protein levels (SeqId = 5009-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MSN protein levels (SeqId = 5009-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Moesin 774 1 Adults (18-65 years) Both European cg26791905 chr1:120254664 1 120254664 PHGDH North shore -0.49 0.126 0.000088 None Gadd-DA_msn_protein_levels__seqid___5009-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TERF1 protein levels (SeqId = 10049-112) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TERF1 protein levels (SeqId = 10049-112) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Telomeric repeat-binding factor 1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.533 0.136 0.000088 None Gadd-DA_terf1_protein_levels__seqid___10049-112__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FABP12 protein levels (SeqId = 18888-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FABP12 protein levels (SeqId = 18888-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fatty acid-binding protein 12 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000088 None Gadd-DA_fabp12_protein_levels__seqid___18888-37__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.0365585 0.00932217 0.00008833499 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09330888 chr1:120280870 1 120280870 PHGDH Open sea 0.0323397 0.00825225 0.00008935879 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 POLI protein levels (SeqId = 13536-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POLI protein levels (SeqId = 13536-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DNA polymerase iota 774 1 Adults (18-65 years) Both European cg05958127 chr1:120254177 1 120254177 PHGDH North shore -0.33 0.084 0.00009 None Gadd-DA_poli_protein_levels__seqid___13536-56__somascan_protein_measurement Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11551257 chr1:120255387 1 120255387 PHGDH Island 0.00444 0.00111 0.000091 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 SMEK1 protein levels (SeqId = 10866-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMEK1 protein levels (SeqId = 10866-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein phosphatase 4 regulatory subunit 3A 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000091 None Gadd-DA_smek1_protein_levels__seqid___10866-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPS6KA1 protein levels (SeqId = 12329-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPS6KA1 protein levels (SeqId = 12329-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ribosomal protein S6 kinase alpha-1 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000091 None Gadd-DA_rps6ka1_protein_levels__seqid___12329-21__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.137427 0.0351213 0.00009153091 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06557491 chr1:120253576 1 120253576 PHGDH North shore 0.0342084 0.00874277 0.00009165778 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PRDX4 protein levels (SeqId = 7789-182) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRDX4 protein levels (SeqId = 7789-182) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peroxiredoxin-4 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.531 0.136 0.000092 None Gadd-DA_prdx4_protein_levels__seqid___7789-182__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 B4GALT3 protein levels (SeqId = 6921-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 B4GALT3 protein levels (SeqId = 6921-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-1,4-galactosyltransferase 3 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000092 None Gadd-DA_b4galt3_protein_levels__seqid___6921-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14819459 chr1:120253398 1 120253398 PHGDH North shore -0.0322764 0.00825227 0.0000922446 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.0322723 0.00825227 0.00009243581 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19563719 chr1:120281196 1 120281196 PHGDH Open sea -0.0322028 0.00825229 0.00009571495 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19096424 chr1:120255104 1 120255104 PHGDH Island 0.00283 0.00071 0.000096 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 BCAR3 protein levels (SeqId = 12634-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCAR3 protein levels (SeqId = 12634-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Breast cancer anti-estrogen resistance protein 3 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.53 0.136 0.000096 None Gadd-DA_bcar3_protein_levels__seqid___12634-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SOD3 protein levels (SeqId = 5660-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SOD3 protein levels (SeqId = 5660-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Extracellular superoxide dismutase [Cu-Zn] 774 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore 0.53 0.136 0.000096 None Gadd-DA_sod3_protein_levels__seqid___5660-51__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03036514 chr1:120255011 1 120255011 PHGDH Island -0.122354 0.0313736 0.00009659107 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0321823 0.00825229 0.00009670303 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07411096 chr1:120253672 1 120253672 PHGDH North shore -0.137333 0.0352206 0.00009686238 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Ma J CARDSYA, FHS, MESA, RS 30936141 2019-02-21 Nonalcoholic fatty liver disease EFO_0003095, EFO_1001248 discovery and replication Table 1 Nonalcoholic fatty liver disease DNA methylation Age, sex, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole Blood, Monocytes None 4525 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000098 None 30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication Battram T ARIES None 2020-08-20 Total lipids in small VLDL EFO_0004529 None None DNA methylation Total lipids in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 681 1 Adults Females European cg14476101 chr1:120255992 1 120255992 PHGDH South shore -0.66 0.167 0.000098 None Battram-T_total_lipids_in_small_vldl Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 3 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 3 = model 2 + BMI 3400 4 Adults Both European cg14476101 chr1:120255992 1 120255992 PHGDH South shore None None 0.000098 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26457483 chr1:120256112 1 120256112 PHGDH South shore -0.0321519 0.0082523 0.00009818306 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CFHR1 protein levels (SeqId = 15468-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFHR1 protein levels (SeqId = 15468-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement factor H-related protein 1 774 1 Adults (18-65 years) Both European cg16246545 chr1:120255941 1 120255941 PHGDH South shore -0.59 0.152 0.000099 None Gadd-DA_cfhr1_protein_levels__seqid___15468-14__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03036514 chr1:120255011 1 120255011 PHGDH Island -0.121849 0.031302 0.00009951327 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18941831 chr1:120272766 1 120272766 PHGDH Open sea -0.0321199 0.00825231 0.00009976827 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1