author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0048	0.00026	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0018	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.0021	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	-0.00071	0.000075	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01073918	chr1:2115256	1	2115256	PRKCZ	North shore	-0.00091	0.000084	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01970427	chr1:2006896	1	2006896	PRKCZ	South shore	-0.0018	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02300356	chr1:2027983	1	2027983	PRKCZ	South shore	-0.00075	0.000069	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.0026	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-0.011	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	0.0074	0.00033	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-0.032	0.002	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0099	0.00093	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02840585	chr1:2090953	1	2090953	PRKCZ	Open sea	0.0025	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02840585	chr1:2090953	1	2090953	PRKCZ	Open sea	-0.013	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03599988	chr1:2045413	1	2045413	PRKCZ	North shore	-0.0025	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03734700	chr1:1999046	1	1999046	PRKCZ	Open sea	-0.0016	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	-0.0047	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	-0.0019	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	0.011	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.0028	0.00026	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05776004	chr1:2100984	1	2100984	PRKCZ	Open sea	-0.001	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	0.0042	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	-0.012	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0033	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	-0.001	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	-0.00091	0.000058	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06757383	chr1:2008579	1	2008579	PRKCZ	South shelf	-0.0009	0.000097	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06791083	chr1:2006465	1	2006465	PRKCZ	South shore	-0.0013	0.0001	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07093776	chr1:2099468	1	2099468	PRKCZ	Open sea	-0.0023	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.0018	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	0.005	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	-0.0018	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	-0.0046	0.00025	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0018	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08484080	chr1:1986139	1	1986139	PRKCZ	South shelf	-0.0012	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.0022	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	-0.0023	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09225489	chr1:2099891	1	2099891	PRKCZ	Open sea	-0.0016	0.0001	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09891066	chr1:2100864	1	2100864	PRKCZ	Open sea	-0.0017	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0019	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	-0.00046	0.000034	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11227141	chr1:2003650	1	2003650	PRKCZ	North shore	-0.0016	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11835265	chr1:2011913	1	2011913	PRKCZ	Open sea	-0.0028	0.00031	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11961999	chr1:2104478	1	2104478	PRKCZ	Open sea	-0.0015	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12085265	chr1:2014628	1	2014628	PRKCZ	Open sea	-0.0014	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	-0.0025	0.0002	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0017	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14599857	chr1:2010959	1	2010959	PRKCZ	Open sea	-0.00028	0.000027	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0019	0.00021	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14989962	chr1:2085717	1	2085717	PRKCZ	South shelf	-0.00065	0.000068	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.0032	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15575834	chr1:2099845	1	2099845	PRKCZ	Open sea	-0.00054	0.000044	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16269144	chr1:2003326	1	2003326	PRKCZ	North shore	-0.0032	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	0.0032	0.00029	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.002	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.015	0.0017	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17025688	chr1:2107410	1	2107410	PRKCZ	Open sea	-0.0015	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17355877	chr1:1998716	1	1998716	PRKCZ	Open sea	-0.0031	0.00035	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.014	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17815669	chr1:2003198	1	2003198	PRKCZ	North shore	-0.0019	0.00021	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0026	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	0.0075	0.00033	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	-0.031	0.002	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20457594	chr1:2109138	1	2109138	PRKCZ	Open sea	-0.00099	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20975074	chr1:2066430	1	2066430	PRKCZ	Island	-0.002	0.00022	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	-0.0012	0.000093	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22174681	chr1:2013930	1	2013930	PRKCZ	Open sea	-0.006	0.00041	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22332339	chr1:2003605	1	2003605	PRKCZ	North shore	-0.0042	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22712840	chr1:2026193	1	2026193	PRKCZ	Island	-0.00093	0.000068	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22868225	chr1:2015815	1	2015815	PRKCZ	Open sea	-0.00034	0.000033	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23276504	chr1:2035462	1	2035462	PRKCZ	North shelf	-0.00092	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	0.0049	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	-0.014	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24054683	chr1:2085751	1	2085751	PRKCZ	South shelf	-0.0021	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0016	0.0002	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24475758	chr1:1998863	1	1998863	PRKCZ	Open sea	-0.0042	0.0003	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.0082	0.00029	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.034	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0033	0.00031	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.018	0.002	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0045	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25319188	chr1:2041103	1	2041103	PRKCZ	Island	-0.00055	0.000051	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25466090	chr1:2064691	1	2064691	PRKCZ	Island	-0.00015	0.000018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26252027	chr1:2012218	1	2012218	PRKCZ	Open sea	-0.00094	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27449973	chr1:2111912	1	2111912	PRKCZ	Open sea	-0.0019	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20975074	chr1:2066430	1	2066430	PRKCZ	Island	0.3448	0.00386	7.3e-159	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.56362	0.0066	2.8e-155	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	0.51278	0.00626	7.1e-152	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20153240	chr1:2016789	1	2016789	PRKCZ	Open sea	0.40288	0.00537	8.900000000000001e-145	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.40704	0.00544	1.9e-144	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27449973	chr1:2111912	1	2111912	PRKCZ	Open sea	0.27998	0.00377	7.4e-144	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.35011	0.00473	1.4e-143	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.34652	0.00496	4.8999999999999996e-139	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.31351	0.00453	3.9999999999999997e-138	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.41466	0.00614	3.2999999999999998e-136	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.41157	0.00672	2.1e-128	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.45526	0.0078	1.3000000000000002e-124	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24042578	chr1:2066981	1	2066981	PRKCZ	South shore	0.56655	0.00977	4.9000000000000005e-124	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-	-	1.01e-123	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	-0.403	0.00713	5e-122	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.22547	0.00415	6e-119	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.38582	0.00715	2.2000000000000003e-118	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.35888	0.00675	3.5e-117	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15481172	chr1:2059086	1	2059086	PRKCZ	Open sea	0.2308	0.00442	9.8e-116	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.42369	0.00829	3.7e-114	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08484080	chr1:1986139	1	1986139	PRKCZ	South shelf	0.42498	0.00835	7.7e-114	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.22866	0.00462	1.4000000000000002e-111	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	0.35538	0.00726	9.999999999999999e-111	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.29401	0.00629	3.0999999999999996e-107	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.179896	0.00812187	5.92073e-107	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	-0.28471	0.00642	3.7e-103	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.175006	0.00812915	3.1027670000000004e-101	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08106279	chr1:2060014	1	2060014	PRKCZ	North shelf	0.24333	0.00564	4.1e-101	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	0.30983	0.00727	3.9000000000000003e-100	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	-0.23765	0.00559	6e-100	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-	-	9.46e-98	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27427908	chr1:2056109	1	2056109	PRKCZ	Open sea	0.199	0.00484	1.8e-97	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	0.21486	0.00527	8.999999999999999e-97	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	0.19166	0.00479	2.2e-95	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19759051	chr1:2030817	1	2030817	PRKCZ	Open sea	0.1481	0.0037	2.2e-95	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09179248	chr1:2046783	1	2046783	PRKCZ	Island	-0.23839	0.00604	2.2e-94	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.168839	0.00813804	2.935494e-94	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.167624	0.00813975	6.472798e-93	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06157219	chr1:2063875	1	2063875	PRKCZ	Island	-0.1636	0.00432	2.9999999999999997e-91	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.16486	0.0081436	6.734706e-90	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11796233	chr1:2060236	1	2060236	PRKCZ	North shelf	0.15609	0.00422	1.4000000000000001e-89	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13072890	chr1:2038377	1	2038377	PRKCZ	North shore	0.1459	0.00398	8.4e-89	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.163825	0.00814502	8.808772e-89	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	-	-	3.82e-88	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.161546	0.00814812	2.383505e-86	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02587648	chr1:2023258	1	2023258	PRKCZ	North shore	-0.22886	0.00655	2.2e-85	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	0.00016	None	3.8e-83	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04771433	chr1:2064216	1	2064216	PRKCZ	North shore	0.11324	0.00336	8.599999999999999e-83	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19370684	chr1:1982688	1	1982688	PRKCZ	Island	0.0014	None	3.1e-82	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.15697	0.00815422	1.424526e-81	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13387826	chr1:2005260	1	2005260	PRKCZ	Island	0.04321	0.00132	8.200000000000001e-81	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	-	-	2.6700000000000002e-80	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22942532	chr1:2089924	1	2089924	PRKCZ	Open sea	0.08618	0.00273	4.3e-78	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	-0.14313	0.00456	8.500000000000001e-78	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.152711	0.00815973	2.948981e-77	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.16363	0.00526	4.1e-77	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.152023	0.0081606	1.4297950000000002e-76	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25304754	chr1:2014547	1	2014547	PRKCZ	Open sea	0.08743	0.00285	4.6e-76	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.14662	0.00479	5.4e-76	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.14488	0.00484	1.9000000000000002e-74	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.22267	0.00744	2.1e-74	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	0.1753	0.00596	2.9e-73	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03732007	chr1:2071316	1	2071316	PRKCZ	Open sea	-0.17707	0.00606	8.7e-73	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.147859	0.00816582	1.724768e-72	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.31623	0.01108	3.7000000000000005e-71	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12718519	chr1:2058417	1	2058417	PRKCZ	Open sea	-0.31259	0.01098	5.5000000000000005e-71	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22342249	chr1:2043439	1	2043439	PRKCZ	North shelf	0.07044	0.0025	2.6999999999999998e-70	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.25372	0.00907	7.799999999999999e-70	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.143681	0.0081709	1.6325840000000002e-68	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	0.07596	0.00277	1.7999999999999998e-68	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18269141	chr1:2063966	1	2063966	PRKCZ	Island	-0.1653	0.00615	3.3e-67	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24447775	chr1:1992534	1	1992534	PRKCZ	South shore	0.0701	0.00263	1.1e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.09088	0.00342	1.7e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.141402	0.00817361	2.150306e-66	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-0.24768	0.00935	3.5e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.141136	0.00817392	3.7783580000000004e-66	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.07801	0.00295	4.8e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.1862	0.00706	6.200000000000001e-66	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05776004	chr1:2100984	1	2100984	PRKCZ	Open sea	0.05562	0.00213	4e-65	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.13971	0.0081756	7.646719e-65	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	0.09194	0.00355	1e-64	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.137951	0.00817763	2.9817129999999997e-63	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.13726	0.00817842	1.2421150000000002e-62	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-	-	4.14e-62	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-0.05143	0.00207	5.499999999999999e-62	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.136251	0.00817957	9.854573e-62	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18803110	chr1:2057439	1	2057439	PRKCZ	Open sea	0.06721	0.00278	2.9e-60	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19370684	chr1:1982688	1	1982688	PRKCZ	Island	0.10967	0.00472	8.400000000000001e-58	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02587648	chr1:2023258	1	2023258	PRKCZ	North shore	0.0031	None	9.400000000000001e-57	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.129165	0.00818741	1.301285e-55	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.129075	0.0081875	1.5511060000000001e-55	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.128511	0.00818811	4.6019120000000004e-55	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.06627	0.00298	4.699999999999999e-55	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	-0.04582	0.00211	1.4e-53	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.126487	0.00819026	2.190409e-53	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07029226	chr1:2104223	1	2104223	PRKCZ	Open sea	0.04747	0.00221	5.499999999999999e-53	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	0.0037	None	1.6e-52	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.123245	0.00819363	9.373519e-51	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.13012	0.00643	1.4e-49	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16059943	chr1:2013748	1	2013748	PRKCZ	Open sea	-	-	3.12e-49	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03734700	chr1:1999046	1	1999046	PRKCZ	Open sea	0.0018	None	5.000000000000001e-49	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-	-	7.32e-49	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.120523	0.00819639	1.3390819999999999e-48	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.11434	0.00582	6e-48	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg08484080	chr1:1986139	1	1986139	PRKCZ	South shelf	-	-	1.2900000000000001e-47	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.119125	0.00819778	1.638672e-47	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.06176	0.00318	3.3999999999999997e-47	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.118138	0.00819875	9.435144e-47	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.117365	0.00819951	3.681108e-46	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.117155	0.00819971	5.310143e-46	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14418633	chr1:2005489	1	2005489	PRKCZ	Island	0.0323	0.00171	8.299999999999999e-46	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	-0.14057	0.00744	9.4e-46	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.115595	0.00820122	8.010563e-45	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg02912476	chr1:2035087	1	2035087	PRKCZ	North shelf	-	-	2.57e-44	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.114863	0.00820192	2.826368e-44	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.114628	0.00820215	4.224438e-44	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10761639	chr1:2023794	1	2023794	PRKCZ	North shore	0.18784	0.01026	4.4e-44	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.05938	0.00329	2.8999999999999997e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	0.06843	0.0038	3.8e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	-	-	3.84e-43	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	0.11737	0.00655	6.0999999999999996e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23820589	chr1:2014244	1	2014244	PRKCZ	Open sea	0.04677	0.00263	1.5e-42	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17156349	chr1:2100232	1	2100232	PRKCZ	Open sea	0.04516	0.00257	6.3e-42	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	-	-	7.04e-41	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.08352	0.00485	7.9e-41	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.110139	0.00820634	7.908892e-41	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	4	0.299	8.2e-40	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-2.54468	0.10722	9.11e-40	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09225489	chr1:2099891	1	2099891	PRKCZ	Open sea	0.04054	0.00242	2.1e-39	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.108018	0.00820826	2.502631e-39	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.107973	0.0082083	2.6881530000000002e-39	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.106585	0.00820954	2.480589e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	-0.02616	0.0016	3.3e-38	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg02361803	chr1:2014371	1	2014371	PRKCZ	Open sea	-	-	3.87e-38	-	23526956_clear_cell_renal_carcinoma
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-1.70807	0.07677	1.14e-37	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	-	-	3.4700000000000004e-37	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.104858	0.00821105	3.787862e-37	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22626579	chr1:2038628	1	2038628	PRKCZ	Island	0.05246	0.00331	8.2e-37	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg27449973	chr1:2111912	1	2111912	PRKCZ	Open sea	-	-	1.64e-36	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.13342	0.00852	3.3e-36	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.103146	0.00821253	5.397268e-36	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02107558	chr1:2000679	1	2000679	PRKCZ	Open sea	0.04082	0.00262	6.9e-36	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.102847	0.00821279	8.537079e-36	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.10267	0.00821294	1.1196000000000001e-35	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg24042578	chr1:2066981	1	2066981	PRKCZ	South shore	-	-	1.17e-35	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	0.02635	0.00171	1.4e-35	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.102395	0.00821317	1.70507e-35	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	0.04562	0.00296	2e-35	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-	-	2.69e-35	-	23526956_clear_cell_renal_carcinoma
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-1.92414	0.0932	2.76e-35	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg07375700	chr1:2013507	1	2013507	PRKCZ	Open sea	-	-	4.23e-35	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.100911	0.00821443	1.618994e-34	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17025688	chr1:2107410	1	2107410	PRKCZ	Open sea	0.03569	0.00237	1.8e-34	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg06157219	chr1:2063875	1	2063875	PRKCZ	Island	-1.88723	0.09408	2.2e-34	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.100315	0.00821492	3.959667e-34	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.03341	0.00225	9.700000000000001e-34	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	-1.80726	0.09239	1.33e-33	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0992478	0.00821581	1.9390480000000002e-33	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg12085265	chr1:2014628	1	2014628	PRKCZ	Open sea	-	-	2.21e-33	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16653138	chr1:2005180	1	2005180	PRKCZ	Island	0.01855	0.00126	3e-33	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0988427	0.00821614	3.5280150000000004e-33	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18888671	chr1:2030462	1	2030462	PRKCZ	Open sea	0.0016	None	7.700000000000001e-33	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0981264	0.00821672	1.010249e-32	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0974403	0.00821728	2.747742e-32	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0970738	0.00821758	4.67583e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	-1.73082	0.09513	2.12e-31	-	25282492_fetal_vs_adult_liver
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg13480549	chr1:2058790	1	2058790	PRKCZ	Open sea	-1.99968	0.11037	2.8300000000000003e-31	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0957558	0.00821863	3.1103799999999997e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04349178	chr1:2026224	1	2026224	PRKCZ	Island	0.04191	0.003	3.7e-31	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg12718519	chr1:2058417	1	2058417	PRKCZ	Open sea	-	-	5.14e-31	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0951858	0.00821908	7.002866e-31	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-	-	7.199999999999999e-31	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.0421	0.00304	9.999999999999999e-31	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	3.6	0.313	1.3000000000000001e-30	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19257562	chr1:2043853	1	2043853	PRKCZ	North shelf	-0.08161	0.00593	1.7e-30	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	0.02786	0.00204	3.6e-30	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0938392	0.00822014	4.6714349999999995e-30	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0930144	0.00822078	1.473895e-29	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-2.41331	0.14242	2.69e-29	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0925044	0.00822117	2.984281e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0923568	0.00822128	3.657274e-29	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.09219	0.00822141	4.6004850000000004e-29	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0921386	0.00822145	4.937488e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14417954	chr1:1981217	1	1981217	PRKCZ	North shore	-0.0256	0.00193	5.7e-29	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.01569	0.00118	5.799999999999999e-29	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03001333	chr1:2005560	1	2005560	PRKCZ	Island	0.03148	0.00237	6.1e-29	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg23820589	chr1:2014244	1	2014244	PRKCZ	Open sea	-	-	7.03e-29	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0918611	0.00822166	7.225037e-29	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0918485	0.00822167	7.350668e-29	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0915881	0.00822187	1.049564e-28	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01164686	chr1:2024593	1	2024593	PRKCZ	North shore	-0.02931	0.00223	1.5000000000000002e-28	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0911019	0.00822224	2.0350990000000003e-28	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11961999	chr1:2104478	1	2104478	PRKCZ	Open sea	0.03507	0.00268	2.1e-28	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg22174681	chr1:2013930	1	2013930	PRKCZ	Open sea	-	-	2.63e-28	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0046	None	3.2000000000000003e-28	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-1.42864	0.08806	4.83e-28	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0903322	0.00822282	5.764225e-28	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0901988	0.00822292	6.897480000000001e-28	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0898706	0.00822316	1.0715660000000001e-27	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0898218	0.0082232	1.1439450000000001e-27	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	-0.02774	0.00217	1.9e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	-	-	2.0500000000000003e-27	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	0.04493	0.00354	2.9e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.02372	0.00187	3.6e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09891066	chr1:2100864	1	2100864	PRKCZ	Open sea	0.03047	0.00241	4e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	0.000092	None	4.3e-27	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0887267	0.00822401	4.914578e-27	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	0.0022	None	5.1e-27	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg22627876	chr1:1988808	1	1988808	PRKCZ	North shore	-	-	1.3500000000000002e-26	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0016	None	1.4e-26	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0870691	0.00822522	4.315022e-26	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0868237	0.00822539	5.931092999999999e-26	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.03096	0.00254	9.999999999999999e-26	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19870743	chr1:2097158	1	2097158	PRKCZ	Open sea	0.02426	0.002	1.5999999999999998e-25	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.0029	None	1.9e-25	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	0.0016	None	2.5e-25	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	0.0017	None	3.4999999999999997e-25	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-1.93013	0.13242	4.5e-25	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0850541	0.00822665	5.727485e-25	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0846336	0.00822695	9.750156000000001e-25	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	-	-	2.58e-24	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0833349	0.00822785	4.959349e-24	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0832794	0.00822789	5.313105e-24	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22712840	chr1:2026193	1	2026193	PRKCZ	Island	0.01578	0.00137	1.0000000000000001e-23	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12711627	chr1:2025769	1	2025769	PRKCZ	Island	-0.03051	0.00266	1.4000000000000002e-23	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0824325	0.00822847	1.513027e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.082364	0.00822852	1.645912e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0819792	0.00822878	2.6375210000000002e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0819749	0.00822878	2.6514530000000004e-23	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0819491	0.0082288	2.736426e-23	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0819435	0.0082288	2.755072e-23	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0816658	0.00822899	3.8660160000000005e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0815547	0.00822907	4.426032e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0815374	0.00822908	4.5200390000000007e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0810804	0.00822939	7.867443000000001e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0807558	0.0082296	1.16411e-22	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0802171	0.00822996	2.222628e-22	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0799731	0.00823013	2.974958e-22	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03734700	chr1:1999046	1	1999046	PRKCZ	Open sea	0.0058	None	4.600000000000001e-22	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0795822	0.00823038	4.736557e-22	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-	-	7.33e-22	-	28056824_age_4_vs_age_0
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	-	-	8.28e-22	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0021	None	1e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06757383	chr1:2008579	1	2008579	PRKCZ	South shelf	-0.01565	0.00145	1.5e-21	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0785955	0.00823103	1.517327e-21	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0785825	0.00823104	1.5405209999999999e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg23844174	chr1:2064819	1	2064819	PRKCZ	Island	-2.9396	0.23255	2.1200000000000003e-21	-	25282492_fetal_vs_adult_liver
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24035370	chr1:1982434	1	1982434	PRKCZ	Island	0.00032	None	2.3e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0782007	0.00823129	2.407761e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0781806	0.0082313	2.464927e-21	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0781133	0.00823134	2.666143e-21	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-	-	2.79e-21	-	28056824_age_4_vs_age_0
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24475758	chr1:1998863	1	1998863	PRKCZ	Open sea	0.0027	None	3.1e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0779601	0.00823144	3.186454e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0774611	0.00823176	5.683571e-21	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.435075	0.0462857	6.098858e-21	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.100909	0.0107356	6.279542e-21	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23803603	chr1:2058230	1	2058230	PRKCZ	Open sea	-0.04026	0.00381	6.5e-21	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0768956	0.00823213	1.0900109999999999e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.03026	0.00288	1.1e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0767632	0.00823221	1.2687129999999999e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0767051	0.00823225	1.355864e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24604214	chr1:2092394	1	2092394	PRKCZ	Open sea	0.04645	0.00445	1.6e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.076414	0.00823243	1.891e-20	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13480549	chr1:2058790	1	2058790	PRKCZ	Open sea	-0.04875	0.00468	2e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.076275	0.00823252	2.2153459999999998e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.28369	0.0308	2.93e-20	-	25650246_gestational_age
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00171113	chr1:2073900	1	2073900	PRKCZ	Open sea	-0.02296	0.00222	3.1e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-5.2	0.5654	3.7e-20	-	28069425_total_serum_ige_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0757532	0.00823285	4.0039699999999994e-20	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0756005	0.00823294	4.758126e-20	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0755767	0.00823296	4.8874019999999995e-20	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-4.1	0.4485	6.2e-20	-	28069425_total_serum_ige_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	0.0023	None	7.1e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0752167	0.00823318	7.328553e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-	-	7.76e-20	-	26857698_primary_sjogrens_syndrome_whole_blood
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	0.0012	None	8.5e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.0750717	0.00823327	8.622097e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07093776	chr1:2099468	1	2099468	PRKCZ	Open sea	0.0021	None	8.7e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0749326	0.00823336	1.007488e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0748642	0.0082334	1.087597e-19	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0748438	0.00823341	1.1126609999999998e-19	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0747348	0.00823348	1.256677e-19	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0976807	0.0107629	1.270781e-19	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0742668	0.00823377	2.1147159999999997e-19	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19412821	chr1:2104786	1	2104786	PRKCZ	Open sea	0.00064	None	2.2e-19	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16813816	chr1:2091066	1	2091066	PRKCZ	Open sea	0.02278	0.00227	2.3e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0740498	0.0082339	2.688902e-19	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0739807	0.00823395	2.90208e-19	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17748900	chr1:2041764	1	2041764	PRKCZ	South shore	0.02052	0.00205	3.3e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0738323	0.00823404	3.4184169999999995e-19	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	0.0013	None	3.5e-19	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03777518	chr1:2045682	1	2045682	PRKCZ	North shore	0.03125	0.00314	4.5e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0733809	0.00823431	5.613578999999999e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0733478	0.00823433	5.821046999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.42227	0.0474583	6.253994999999999e-19	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22332339	chr1:2003605	1	2003605	PRKCZ	North shore	0.002	None	8.1e-19	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0729971	0.00823454	8.53877e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.072806	0.00823466	1.05135e-18	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg02587648	chr1:2023258	1	2023258	PRKCZ	North shore	-1.56345	0.13887	1.14e-18	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0727206	0.00823471	1.1535e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0726895	0.00823473	1.193179e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19900677	chr1:1999533	1	1999533	PRKCZ	Open sea	-0.01899	0.00194	1.2e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg22942532	chr1:2089924	1	2089924	PRKCZ	Open sea	-0.29787	0.0338	1.28e-18	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.418583	0.0475694	1.50248e-18	None	39706196_Hannah-M.-Smith_body_fat_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	0.002	None	1.6e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0721753	0.00823504	2.0806870000000002e-18	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0721718	0.00823504	2.0886400000000003e-18	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0721435	0.00823506	2.153383e-18	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	0.05855	0.00605	2.6e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0717798	0.00823527	3.183051e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0932758	0.0107119	3.427795e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17815669	chr1:2003198	1	2003198	PRKCZ	North shore	0.0018	None	4e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0715426	0.00823541	4.103085e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0715109	0.00823543	4.244469e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.0713805	0.00823551	4.877671e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	-	-	5.07e-18	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0713389	0.00823553	5.099233e-18	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20457594	chr1:2109138	1	2109138	PRKCZ	Open sea	0.01754	0.00183	5.1e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0713078	0.00823555	5.27093e-18	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03777518	chr1:2045682	1	2045682	PRKCZ	North shore	0.0015	None	5.6e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0712243	0.0082356	5.760867e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0712036	0.00823561	5.889219e-18	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg15481172	chr1:2059086	1	2059086	PRKCZ	Open sea	-0.31343	0.0363	5.89e-18	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0711915	0.00823562	5.96541e-18	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	0.03231	0.00338	6.1e-18	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.071146	0.00823565	6.2607e-18	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13798228	chr1:2106732	1	2106732	PRKCZ	Open sea	0.0033	None	8e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0708337	0.00823583	8.719060000000001e-18	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0706967	0.00823591	1.007755e-17	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0706239	0.00823595	1.0882520000000001e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0706222	0.00823596	1.090214e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.070583	0.00823598	1.1362140000000001e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.19868	0.0232	1.14e-17	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0704326	0.00823607	1.331251e-17	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0702412	0.00823618	1.627719e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.070158	0.00823623	1.77607e-17	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0701226	0.00823625	1.84321e-17	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-4.42	0.5203	1.98e-17	-	28069425_total_serum_ige_puerto_ricans_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0700183	0.00823631	2.0558870000000002e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0696169	0.00823654	3.125089e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0696004	0.00823655	3.179065e-17	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09225489	chr1:2099891	1	2099891	PRKCZ	Open sea	0.00088	None	3.3e-17	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-	-	4.07e-17	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0692687	0.00823674	4.485053e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0691772	0.00823679	4.930307e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0691674	0.0082368	4.9801980000000004e-17	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0689525	0.00823692	6.216701e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	0.00898	0.00098	6.7e-17	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02482150	chr1:2008365	1	2008365	PRKCZ	South shelf	0.002	None	9.8e-17	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.009	0.00091	1.1e-16	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0682829	0.0082373	1.235419e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0682603	0.00823731	1.264143e-16	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0881875	0.0106633	1.451156e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0681129	0.0082374	1.469088e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0018	None	1.6e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.067998	0.00823746	1.651324e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0678785	0.00823753	1.864323e-16	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	-0.012	0.0014	2.2e-16	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07029226	chr1:2104223	1	2104223	PRKCZ	Open sea	-0.0007	0.000086	2.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08115172	chr1:1990868	1	1990868	PRKCZ	Island	-0.00085	0.0001	2.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.003	0.00036	2.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg20153240	chr1:2016789	1	2016789	PRKCZ	Open sea	-0.31139	0.038	2.36e-16	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0676281	0.00823767	2.40258e-16	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0022	None	2.5e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	0.0023	None	2.5e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.04631	0.00517	2.8e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0674269	0.00823778	2.943663e-16	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07196858	chr1:2085232	1	2085232	PRKCZ	South shelf	0.002	None	3.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg25466090	chr1:2064691	1	2064691	PRKCZ	Island	-2.20718	0.21984	3.35e-16	-	25282492_fetal_vs_adult_liver
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02912476	chr1:2035087	1	2035087	PRKCZ	North shelf	0.00056	None	3.6e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03959306	chr1:2004968	1	2004968	PRKCZ	North shore	0.0016	None	3.6e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12085265	chr1:2014628	1	2014628	PRKCZ	Open sea	0.02173	0.00244	3.8e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	-0.15679	0.0193	4.14e-16	-	25650246_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0017	0.00021	4.4e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.13489	0.0152	4.8e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0669135	0.00823807	4.929385e-16	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	0.0068	None	5e-16	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07382156	chr1:2085526	1	2085526	PRKCZ	South shelf	-0.01822	0.00205	5e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0668859	0.00823808	5.067095e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.00080338	9.78e-05	6.13e-16	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0019	None	6.2e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05706173	chr1:2104310	1	2104310	PRKCZ	Open sea	0.0016	None	6.5e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12297010	chr1:2096582	1	2096582	PRKCZ	Open sea	-0.0014	0.00017	6.7e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20153240	chr1:2016789	1	2016789	PRKCZ	Open sea	0.0013	None	6.9e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0665488	0.00823827	7.092575e-16	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13918804	chr1:2043761	1	2043761	PRKCZ	North shelf	-0.11764	0.01335	7.2e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0867968	0.0107553	7.561581e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0664629	0.00823832	7.725397e-16	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03001333	chr1:2005560	1	2005560	PRKCZ	Island	0.00084	None	7.8e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0755432	0.00936767	7.935382e-16	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18888671	chr1:2030462	1	2030462	PRKCZ	Open sea	0.0049	None	9.8e-16	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	0.00028	None	0.000000000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27587033	chr1:2006032	1	2006032	PRKCZ	South shore	-0.01773	0.00202	0.000000000000001	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg13480549	chr1:2058790	1	2058790	PRKCZ	Open sea	-0.18746	0.0234	0.00000000000000108	-	25650246_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	-0.0014	0.00017	0.0000000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25726135	chr1:2088708	1	2088708	PRKCZ	Open sea	-0.01635	0.00187	0.0000000000000012	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0656387	0.00823877	0.000000000000001743921	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0656141	0.00823878	0.000000000000001786593	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18888671	chr1:2030462	1	2030462	PRKCZ	Open sea	-0.0012	0.00016	0.0000000000000018	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0655837	0.0082388	0.000000000000001840618	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0655329	0.00823882	0.000000000000001934624	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0655276	0.00823883	0.000000000000001944735	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0654585	0.00823886	0.000000000000002080946	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18877309	chr1:2105343	1	2105343	PRKCZ	Open sea	0.001	None	0.0000000000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.065307	0.00823895	0.000000000000002413374	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0304	0.00354	0.0000000000000027	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0651328	0.00823904	0.000000000000002860298	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0650344	0.00823909	0.000000000000003148022	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0649396	0.00823914	0.000000000000003451915	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14778173	chr1:2103645	1	2103645	PRKCZ	Open sea	0.0015	None	0.0000000000000039	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16653138	chr1:2005180	1	2005180	PRKCZ	Island	-0.00051	0.000065	0.000000000000004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26221719	chr1:2000462	1	2000462	PRKCZ	Open sea	-0.00042	0.000053	0.0000000000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0645369	0.00823936	0.000000000000005098876	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25139718	chr1:2027575	1	2027575	PRKCZ	South shore	-0.0011	0.00014	0.0000000000000053	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0644066	0.00823943	0.000000000000005781703	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.022	0.00236	0.0000000000000062	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.064328	0.00823947	0.000000000000006236088	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-0.3195	0.041	0.00000000000000645	-	25650246_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-1.7	0.218	0.0000000000000069	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0640548	0.00823962	0.000000000000008107791	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0639729	0.00823966	0.000000000000008769566	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	0.02801	0.00334	0.00000000000001	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0637048	0.0082398	0.00000000000001133005	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0636659	0.00823982	0.00000000000001175805	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0635702	0.00823987	0.00000000000001287976	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0635657	0.00823987	0.00000000000001293479	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2316245 (gene symbol: PRKCZ)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2316245 (gene symbol: PRKCZ)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	None	None	0.000000000000013	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2316245__gene_symbol__prkcz__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12297010	chr1:2096582	1	2096582	PRKCZ	Open sea	0.02479	0.00297	0.000000000000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0635454	0.00823988	0.00000000000001318797	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.044	0.00493	0.000000000000014	None	32795589_Kyung-WK_eosinophilia_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23276504	chr1:2035462	1	2035462	PRKCZ	North shelf	0.02046	0.00245	0.000000000000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0634199	0.00823995	0.0000000000000148581	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0019	None	0.000000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03777518	chr1:2045682	1	2045682	PRKCZ	North shore	-0.0014	0.00018	0.000000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00653281	chr1:1991051	1	1991051	PRKCZ	Island	-0.0012	0.00015	0.000000000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	0.01806	0.00217	0.000000000000016	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-1.68	0.219	0.000000000000017	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg12718519	chr1:2058417	1	2058417	PRKCZ	Open sea	-0.22557	0.0294	0.0000000000000172	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0632321	0.00824005	0.00000000000001775291	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	-0.0015	0.0002	0.000000000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.046	0.00516	0.00000000000002	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0630809	0.00824013	0.00000000000002048049	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0630613	0.00824014	0.00000000000002086446	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0630331	0.00824015	0.00000000000002142647	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0895372	0.0117387	0.00000000000002539585	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	-0.01363	0.00166	0.000000000000026	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0627701	0.00824029	0.00000000000002744888	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0626935	0.00824033	0.00000000000002949523	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0625786	0.00824039	0.00000000000003285225	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15575834	chr1:2099845	1	2099845	PRKCZ	Open sea	0.00035	None	0.000000000000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02854763	chr1:2103155	1	2103155	PRKCZ	Open sea	-0.00025	0.000032	0.00000000000004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	0.00043	None	0.00000000000004	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.03037	0.00372	0.000000000000041	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	-0.00037	0.00005	0.000000000000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.0093	0.0011	0.000000000000043	None	33564054_Kashima-K_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25319188	chr1:2041103	1	2041103	PRKCZ	Island	0.0004	None	0.000000000000045	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0622392	0.00824056	0.00000000000004511416	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	-0.00036	0.000048	0.000000000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0621411	0.00824061	0.00000000000004943134	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0620388	0.00824067	0.00000000000005436574	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0619059	0.00824074	0.00000000000006150014	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0619043	0.00824074	0.00000000000006159168	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0618717	0.00824075	0.00000000000006348109	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15502607	chr1:1990986	1	1990986	PRKCZ	Island	-0.0016	0.00021	0.000000000000067	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25319188	chr1:2041103	1	2041103	PRKCZ	Island	0.0014	None	0.000000000000068	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg09651011	chr1:2091677	1	2091677	PRKCZ	Open sea	-0.015	0.00173	0.000000000000068	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00171113	chr1:2073900	1	2073900	PRKCZ	Open sea	-0.0012	0.00016	0.000000000000069	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0617765	0.0082408	0.00000000000006933234	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01970427	chr1:2006896	1	2006896	PRKCZ	South shore	0.0041	None	0.000000000000072	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0617098	0.00824084	0.00000000000007374635	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.061526	0.00824093	0.00000000000008737692	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.434049	0.0582032	0.00000000000009236815	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0614607	0.00824096	0.00000000000009279683	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0612147	0.00824109	0.0000000000001163399	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0892801	0.0120223	0.0000000000001179232	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	-0.002	0.00028	0.00000000000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08000672	chr1:2012434	1	2012434	PRKCZ	Open sea	0.0015	None	0.00000000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0610387	0.00824118	0.0000000000001366778	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.351421	0.0474546	0.0000000000001367572	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.061037	0.00824118	0.0000000000001368909	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.00071942	9.6e-05	0.000000000000139	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	0.0012	None	0.00000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06888836	chr1:2074268	1	2074268	PRKCZ	Open sea	-0.0012	0.00016	0.00000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	0.0013	None	0.00000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25845463	chr1:2064046	1	2064046	PRKCZ	Island	-0.04688	0.00588	0.00000000000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0609972	0.0082412	0.0000000000001419651	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0693904	0.00938133	0.0000000000001472353	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08106279	chr1:2060014	1	2060014	PRKCZ	North shelf	-0.0011	0.00015	0.00000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	0.0015	None	0.00000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.060899	0.00824125	0.0000000000001552863	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg17025688	chr1:2107410	1	2107410	PRKCZ	Open sea	-2.476049	0.3357	0.000000000000162	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0694165	0.00941159	0.0000000000001723055	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0607105	0.00824134	0.0000000000001843869	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg19759051	chr1:2030817	1	2030817	PRKCZ	Open sea	-0.3362	0.0457	0.000000000000188	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0605794	0.00824141	0.0000000000002077154	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	0.0014	None	0.00000000000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0605639	0.00824142	0.0000000000002106546	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0605133	0.00824144	0.0000000000002205598	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0604968	0.00824145	0.0000000000002238876	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11835265	chr1:2011913	1	2011913	PRKCZ	Open sea	0.01528	0.00194	0.00000000000024	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	-0.0603896	0.0082415	0.0000000000002467065	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0603237	0.00824154	0.0000000000002618743	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0601365	0.00824163	0.0000000000003100877	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0600919	0.00824165	0.0000000000003227979	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0599971	0.0082417	0.0000000000003515597	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	0.21002	0.0289	0.000000000000357	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0599511	0.00824172	0.0000000000003663861	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.141945	0.0195201	0.0000000000003727946	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11835265	chr1:2011913	1	2011913	PRKCZ	Open sea	0.0024	None	0.00000000000039	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0598703	0.00824176	0.0000000000003939811	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0597791	0.00824181	0.0000000000004275342	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0596711	0.00824186	0.0000000000004709374	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24035370	chr1:1982434	1	1982434	PRKCZ	Island	0.001	None	0.00000000000049	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.059546	0.00824192	0.0000000000005266555	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.043	0.00521	0.00000000000053	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0595128	0.00824194	0.0000000000005425043	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	-	-	0.000000000000549	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0594843	0.00824195	0.0000000000005564777	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0594714	0.00824196	0.0000000000005629365	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0594598	0.00824196	0.0000000000005687532	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0594412	0.00824197	0.0000000000005782642	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	0.0445	0.00577	0.00000000000063	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0592887	0.00824205	0.0000000000006623276	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25139718	chr1:2027575	1	2027575	PRKCZ	South shore	0.01793	0.00233	0.00000000000067	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg14989962	chr1:2085717	1	2085717	PRKCZ	South shelf	-0.01394	0.0019	0.000000000000716	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0591982	0.00824209	0.0000000000007178297	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0591373	0.00824212	0.0000000000007576615	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.75927442	0.1059	0.000000000000764	-	27602958_smoking_packyears_discovery_and_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18877309	chr1:2105343	1	2105343	PRKCZ	Open sea	-0.00085	0.00012	0.0000000000008	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0625298	0.00872544	0.0000000000008067909	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0590021	0.00824219	0.0000000000008540631	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	0.0095	0.0012	0.00000000000086	None	33564054_Kashima-K_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.347502	0.0485629	0.0000000000008658253	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.440441	0.0616284	0.0000000000009242212	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.05887	0.00824225	0.0000000000009598645	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0588397	0.00824227	0.0000000000009858463	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0017	None	0.000000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.039	0.00481	0.000000000001	None	32795589_Kyung-WK_atopy_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03001333	chr1:2005560	1	2005560	PRKCZ	Island	-0.00075	0.00011	0.0000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	0.0016	None	0.0000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0586599	0.00824235	0.000000000001155117	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0586564	0.00824236	0.000000000001158696	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.102358	0.0143969	0.000000000001216797	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0584835	0.00824244	0.000000000001348816	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.138649	0.0195543	0.000000000001398019	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.05827	0.00824254	0.000000000001626118	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0582372	0.00824256	0.000000000001673385	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08659047	chr1:2022951	1	2022951	PRKCZ	North shelf	0.0282	0.00374	0.0000000000017	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.058158	0.0082426	0.000000000001793184	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	0.0055	0.00069	0.0000000000018	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0580938	0.00824263	0.000000000001896452	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.011	0.0015	0.0000000000019	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0580698	0.00824264	0.000000000001936459	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	0.004	None	0.000000000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg16059943	chr1:2013748	1	2013748	PRKCZ	Open sea	0.038	0.00475	0.000000000002	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0579508	0.0082427	0.000000000002147932	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0579286	0.00824271	0.00000000000218974	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0578277	0.00824275	0.000000000002390234	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12711627	chr1:2025769	1	2025769	PRKCZ	Island	-0.0013	0.00019	0.0000000000025	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0577663	0.00824278	0.000000000002520898	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0577153	0.00824281	0.000000000002634809	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25060388	chr1:2096722	1	2096722	PRKCZ	Open sea	-0.00072	0.0001	0.0000000000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14204564	chr1:2018252	1	2018252	PRKCZ	Open sea	0.002	None	0.0000000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.03	0.00372	0.000000000003	None	32795589_Kyung-WK_atopy_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	0.001	0.00015	0.0000000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0574521	0.00824293	0.000000000003307996	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.057452	0.00824293	0.000000000003308132	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.02518	0.00339	0.0000000000034	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.057418	0.00824295	0.000000000003406638	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0574035	0.00824296	0.00000000000344944	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.069	0.00996	0.0000000000035	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21137823	chr1:1981270	1	1981270	PRKCZ	Island	0.0011	None	0.0000000000037	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0572978	0.00824301	0.000000000003777807	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.015	0.0021	0.0000000000039	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0571787	0.00824306	0.000000000004184887	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0571577	0.00824307	0.000000000004261208	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0996753	0.0143752	0.000000000004267637	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0571434	0.00824308	0.000000000004313884	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0571369	0.00824308	0.000000000004337849	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24035370	chr1:1982434	1	1982434	PRKCZ	Island	0.00025	0.000036	0.0000000000044	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0570582	0.00824312	0.000000000004640559	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0718717	0.0103849	0.000000000004676682	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19759051	chr1:2030817	1	2030817	PRKCZ	Open sea	-0.01058	0.0015	0.00000000000497	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0569747	0.00824316	0.000000000004984194	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0598955	0.00866851	0.000000000005062215	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0569477	0.00824317	0.000000000005100692	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0569199	0.00824319	0.000000000005223427	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0568074	0.00824324	0.000000000005750073	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg02912476	chr1:2035087	1	2035087	PRKCZ	North shelf	-0.014	0.0018	0.000000000006	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0567028	0.00824329	0.000000000006286189	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.065	0.00838	0.0000000000064	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.056662	0.00824331	0.000000000006508066	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16059943	chr1:2013748	1	2013748	PRKCZ	Open sea	-0.15877	0.0231	0.00000000000667	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.0566199	0.00824333	0.000000000006745583	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13591369	chr1:2005564	1	2005564	PRKCZ	Island	0.01942	0.00265	0.0000000000068	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0565106	0.00824338	0.000000000007401651	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.001	0.00015	0.0000000000076	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	-0.17039	0.0249	0.00000000000765	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.056456	0.0082434	0.00000000000775287	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0564291	0.00824342	0.000000000007931186	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	-0.0221	0.0032	0.00000000000796	-	23334450_rheumatoid_arthritis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.0183	0.00251	0.0000000000082	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	0.03734	0.00514	0.0000000000089	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0562669	0.00824349	0.000000000009098267	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0562455	0.0082435	0.000000000009264728	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0562411	0.0082435	0.000000000009298914	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.18732	0.0275	0.00000000000942	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0722527	0.0105969	0.000000000009574073	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0561987	0.00824352	0.000000000009638152	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03001333	chr1:2005560	1	2005560	PRKCZ	Island	0.0028	None	0.00000000001	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0561495	0.00824355	0.00000000001004677	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0560782	0.00824358	0.00000000001066846	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0559667	0.00824363	0.00000000001171826	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0559464	0.00824364	0.00000000001191967	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M00054_tryptophan	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M00054_tryptophan	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.46	0.024	0.000000000012	None	24014485_Petersen-A-K_m00054_tryptophan_snps_as_covariates_model
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-1.3493311	0.1993	0.000000000013	-	27602958_smoking_packyears_lung_squamous_cell
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0557831	0.00824372	0.00000000001367119	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0015	0.00023	0.000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12085265	chr1:2014628	1	2014628	PRKCZ	Open sea	0.0012	None	0.000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.419326	0.0620376	0.00000000001431665	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0556871	0.00824376	0.00000000001481546	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.05	0.00662	0.000000000016	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0555701	0.00824381	0.00000000001633657	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0726245	0.010777	0.00000000001655949	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0555256	0.00824383	0.00000000001695548	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0554939	0.00824385	0.00000000001740897	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00312809	chr1:2028213	1	2028213	PRKCZ	South shore	-0.01968	0.00276	0.000000000018	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.055424	0.00824388	0.00000000001845315	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	-0.0554182	0.00824388	0.00000000001854225	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.055381	0.0082439	0.00000000001912674	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0553748	0.0082439	0.00000000001922495	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-0.207803	0.0309644	0.00000000001989579	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02854763	chr1:2103155	1	2103155	PRKCZ	Open sea	-0.00611	0.00086	0.00000000002	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14417954	chr1:1981217	1	1981217	PRKCZ	North shore	0.00057	None	0.00000000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0553242	0.00824393	0.00000000002005228	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0553203	0.00824393	0.00000000002011664	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0552379	0.00824397	0.00000000002154154	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0552283	0.00824397	0.0000000000217134	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0551873	0.00824399	0.00000000002246597	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.22482	0.0336	0.0000000000228	-	25650246_gestational_age
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-2.7	0.405	0.000000000023	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25407448	chr1:2043037	1	2043037	PRKCZ	South shore	0.01835	0.00258	0.000000000023	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	-0.0551322	0.00824401	0.00000000002351569	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.055086	0.00824403	0.00000000002443199	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0550445	0.00824405	0.00000000002528612	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Bozack	PRISM	34569420	Oct 22, 2021	Infant sex	PATO_0001894	Umbilical artery	Supplementary table 10	DNA methylation	Infant sex	Cell composition (reference free), Batch effects, Ancestry (other)	M values	None	Illumina HumanMethylation450	Umbilical artery	None	229	1	Infants	Both	European, African, Other	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	None	None	0.000000000026	None	34569420_Bozack_infant_sex_umbilical_artery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0549031	0.00824412	0.00000000002841985	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21137823	chr1:1981270	1	1981270	PRKCZ	Island	0.00087	0.00013	0.000000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.6896276	0.1037	0.0000000000292	-	25888029_ageing
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	2.1	0.317	0.00000000003	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0548179	0.00824416	0.00000000003048861	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19619416	chr1:1992232	1	1992232	PRKCZ	South shore	-0.0168	0.00238	0.000000000031	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.13496	0.0203	0.0000000000314	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0547766	0.00824418	0.00000000003154457	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0547417	0.00824419	0.00000000003246257	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0547393	0.00824419	0.00000000003252917	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.042	0.00563	0.000000000033	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22174681	chr1:2013930	1	2013930	PRKCZ	Open sea	-0.017	0.0026	0.000000000033	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2316245 (gene symbol: PRKCZ)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2316245 (gene symbol: PRKCZ)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg19257562	chr1:2043853	1	2043853	PRKCZ	North shelf	None	None	0.000000000038	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2316245__gene_symbol__prkcz__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0545061	0.0082443	0.00000000003939218	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0544433	0.00824433	0.00000000004147366	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	0.0012	None	0.000000000042	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.002	0.0003	0.000000000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0566643	0.00858461	0.00000000004233489	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.054374	0.00824436	0.0000000000438918	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	-	-	0.0000000000502	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0706129	0.0107438	0.00000000005118141	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg18803110	chr1:2057439	1	2057439	PRKCZ	Open sea	-1.904249	0.29	0.0000000000516	-	27105112_hiv_infection_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.349729	0.0532688	0.00000000005338413	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.228506	0.0348378	0.00000000005565734	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0540785	0.00824449	0.00000000005585044	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-0.007	0.0011	0.000000000056	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0540632	0.0082445	0.00000000005655355	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0540319	0.00824451	0.00000000005800653	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.054001	0.00824452	0.00000000005948264	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0728715	0.011136	0.00000000006197985	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg02854763	chr1:2103155	1	2103155	PRKCZ	Open sea	-1.869044	0.2862	0.0000000000657	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0564827	0.00864616	0.00000000006672619	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Replication	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	445	1	79	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-	-	0.0000000000669	-	25249537_sex_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0538537	0.00824459	0.00000000006703033	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0538175	0.00824461	0.00000000006902796	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21221161	chr1:1999183	1	1999183	PRKCZ	Open sea	0.01943	0.00281	0.000000000072	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0685262	0.0105139	0.00000000007374805	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0537131	0.00824465	0.00000000007510876	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0537124	0.00824465	0.00000000007514923	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	2	0.308	0.000000000077	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26610624	chr1:1981268	1	1981268	PRKCZ	Island	-0.0084	0.0013	0.000000000079	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0536107	0.0082447	0.00000000008158107	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.067	0.01	0.000000000083	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0535885	0.00824471	0.00000000008305702	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16059943	chr1:2013748	1	2013748	PRKCZ	Open sea	-0.0012	0.00018	0.000000000088	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0535072	0.00824474	0.0000000000886768	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0534053	0.00824479	0.0000000000962488	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0698287	0.0107818	0.00000000009684963	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	-0.01136	0.00166	0.000000000099	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg19900677	chr1:1999533	1	1999533	PRKCZ	Open sea	0.18985	0.0294	0.000000000101	-	25650246_gestational_age
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.61485768	0.0951	0.000000000101	-	27602958_smoking_packyears_discovery_and_replication
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg25060388	chr1:2096722	1	2096722	PRKCZ	Open sea	-0.01193	0.0018	0.000000000103	-	23334450_rheumatoid_arthritis
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	-0.01251	0.0019	0.000000000107	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12718519	chr1:2058417	1	2058417	PRKCZ	Open sea	0.0022	None	0.00000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19412821	chr1:2104786	1	2104786	PRKCZ	Open sea	-0.00048	0.000074	0.00000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	0.201543	0.0312645	0.0000000001175765	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0530781	0.00824493	0.0000000001251033	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.063221	0.00982409	0.0000000001270592	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03001333	chr1:2005560	1	2005560	PRKCZ	Island	-1.524298	0.2371	0.000000000129	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07382156	chr1:2085526	1	2085526	PRKCZ	South shelf	0.00083	None	0.00000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19405842	chr1:2038661	1	2038661	PRKCZ	Island	0.0026	None	0.00000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0994808	0.0154714	0.0000000001315868	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg08651178	chr1:2035295	1	2035295	PRKCZ	North shelf	0.18908	0.0294	0.000000000132	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0530033	0.00824497	0.0000000001327959	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg22626579	chr1:2038628	1	2038628	PRKCZ	Island	-0.1856078	0.0288972	0.0000000001336	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.35676	0.0555343	0.0000000001360833	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0529492	0.00824499	0.0000000001386479	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	14	None	0.00000000014	None	34044884_Inkster-A_sex_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.04284	0.00631	0.00000000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0529078	0.00824501	0.0000000001432967	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0528565	0.00824503	0.0000000001492771	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	0.0083	None	0.00000000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02587648	chr1:2023258	1	2023258	PRKCZ	North shore	0.0016	0.00025	0.00000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0527642	0.00824507	0.0000000001606311	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	1.5	0.239	0.00000000017	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0526759	0.00824511	0.0000000001722991	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.052642	0.00824512	0.0000000001769944	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	0.0031	None	0.00000000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	0.00089	None	0.00000000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	0.01969	0.0031	0.000000000207	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22332100	chr1:2000508	1	2000508	PRKCZ	Open sea	-0.00022	0.000035	0.00000000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	0.052371	0.00824524	0.000000000219277	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	0.0048	None	0.00000000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	0.00087	None	0.00000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0982945	0.0155011	0.0000000002347923	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.05228	0.00824528	0.0000000002355754	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0522531	0.00824529	0.0000000002406166	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.012	0.0019	0.00000000025	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0521745	0.00824533	0.0000000002559661	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.0521231	0.00824535	0.0000000002665091	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01974180	chr1:2084246	1	2084246	PRKCZ	South shore	-0.01344	0.00202	0.00000000027	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg15115072	chr1:2002722	1	2002722	PRKCZ	North shelf	0.016	0.00224	0.00000000027	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0519895	0.00824541	0.0000000002959276	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0755491	0.0119944	0.0000000003087191	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19370684	chr1:1982688	1	1982688	PRKCZ	Island	0.00056	0.000089	0.00000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0519293	0.00824543	0.0000000003101965	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0519008	0.00824544	0.000000000317203	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0518562	0.00824546	0.00000000032844	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0046	None	0.00000000034	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0076	0.0012	0.00000000035	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0517555	0.00824551	0.0000000003552948	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0517229	0.00824552	0.0000000003644547	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	0.196241	0.0313382	0.0000000003889125	None	39706196_Hannah-M.-Smith_body_fat_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13480549	chr1:2058790	1	2058790	PRKCZ	Open sea	0.00051	0.000082	0.00000000039	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.2038912	0.0326062	0.0000000004023	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24776480	chr1:2066446	1	2066446	PRKCZ	Island	0.01363	0.00207	0.00000000041	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.00039	None	0.00000000043	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27427908	chr1:2056109	1	2056109	PRKCZ	Open sea	-0.00061	0.000098	0.00000000045	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0514315	0.00824564	0.0000000004570718	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0514065	0.00824565	0.0000000004660001	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0513721	0.00824567	0.0000000004785698	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	-0.01	0.0016	0.00000000048	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24035370	chr1:1982434	1	1982434	PRKCZ	Island	0.00838	0.00128	0.00000000048	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.0513571	0.00824568	0.000000000484173	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0513521	0.00824568	0.0000000004860565	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0513255	0.00824569	0.0000000004961603	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18269141	chr1:2063966	1	2063966	PRKCZ	Island	-0.002	0.00032	0.00000000051	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	0.0512577	0.00824572	0.0000000005228377	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13918804	chr1:2043761	1	2043761	PRKCZ	North shelf	0.0027	None	0.00000000053	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21137823	chr1:1981270	1	1981270	PRKCZ	Island	-0.008	0.0013	0.00000000054	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19923417	chr1:2002516	1	2002516	PRKCZ	North shelf	-0.00023	0.000037	0.00000000055	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0511907	0.00824575	0.0000000005506029	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.0511819	0.00824575	0.0000000005543463	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02587648	chr1:2023258	1	2023258	PRKCZ	North shore	0.006	None	0.00000000057	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0510689	0.0082458	0.0000000006047799	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0510229	0.00824582	0.0000000006265645	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0015	None	0.00000000063	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26610624	chr1:1981268	1	1981268	PRKCZ	Island	0.00079	0.00013	0.00000000066	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0509438	0.00824585	0.0000000006658771	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0509139	0.00824586	0.0000000006813383	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.0521171	0.00844164	0.0000000006841989	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0048	8e-04	0.00000000072	-	25935004_waist_circumference_discovery
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	-0.19721	0.032	0.000000000721	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08038080	chr1:2004864	1	2004864	PRKCZ	North shore	-0.250336	0.04062	0.0000000007294134	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.052	0.00846	0.00000000073	None	Robert-F-Hillary_Incident_COPD_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.359617	0.0583662	0.0000000007370507	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0508064	0.00824591	0.0000000007398673	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0565454	0.00917899	0.0000000007450151	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg23844174	chr1:2064819	1	2064819	PRKCZ	Island	0.00966	0.0016	0.000000000775	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.050727	0.00824594	0.0000000007862253	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-1.17	0.19	0.00000000079	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg27427908	chr1:2056109	1	2056109	PRKCZ	Open sea	-0.01188	0.0019	0.000000000802	-	23334450_rheumatoid_arthritis
Petersen A-K	KORA F4	24014485	2013-09-06	M32654_3-dehydrocarnitine*	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32654_3-dehydrocarnitine*	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg15033013	chr1:2082458	1	2082458	PRKCZ	Island	0.71	0.038	0.00000000082	None	24014485_Petersen-A-K_m32654_3-dehydrocarnitine__snps_as_covariates_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.262799	0.042825	0.0000000008614762	None	39706196_Hannah-M.-Smith_bmi_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg22627876	chr1:1988808	1	1988808	PRKCZ	North shore	-0.00898	0.0015	0.000000000876	-	23334450_rheumatoid_arthritis
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.00419	0.00068	0.00000000089	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	2.2	0.363	0.00000000089	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0505447	0.00824602	0.0000000009036105	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0505371	0.00824602	0.000000000908859	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	main	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg00443516	chr1:2061836	1	2061836	PRKCZ	North shore	-0.00815	0.00133	0.00000000091	None	33279932_Li-M_schizophrenia_main
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.026	0.0038	0.00000000093	None	32795589_Kyung-WK_eosinophilia_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.232933	0.0380726	0.0000000009672422	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0503505	0.0082461	0.000000001047523	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0503253	0.00824611	0.000000001067712	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0503057	0.00824612	0.000000001083745	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0502687	0.00824613	0.000000001114555	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0502404	0.00824614	0.000000001138745	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0502034	0.00824616	0.000000001171096	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.00086389	0.00014076	0.00000000118	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0501907	0.00824617	0.000000001182445	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	fixed effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.71	0.117	0.0000000012	None	33646943_Hannon-E_schizophrenia_fixed_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0500845	0.00824621	0.000000001281285	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0500654	0.00824622	0.000000001299915	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.00089	0.00015	0.0000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.00099	0.00016	0.0000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0499615	0.00824626	0.000000001405961	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-	-	0.00000000142	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0827928	0.0136698	0.000000001424042	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0499328	0.00824627	0.000000001436731	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0499017	0.00824628	0.000000001470758	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0497913	0.00824633	0.00000000159801	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02138098	chr1:2040968	1	2040968	PRKCZ	North shore	-0.00074	0.00012	0.0000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-1.62	0.269	0.0000000016	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26561349	chr1:2020591	1	2020591	PRKCZ	Open sea	-0.00069	0.00012	0.0000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0497861	0.00824633	0.000000001604301	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0497552	0.00824635	0.00000000164204	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.0497409	0.00824635	0.000000001659663	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.0078	0.0013	0.0000000017	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23629792	chr1:1987129	1	1987129	PRKCZ	North shelf	0.001	None	0.0000000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0496985	0.00824637	0.000000001713331	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0496947	0.00824637	0.000000001718253	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0496883	0.00824637	0.000000001726472	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0496685	0.00824638	0.000000001752366	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11796233	chr1:2060236	1	2060236	PRKCZ	North shelf	-0.265059	0.0440596	0.000000001822796	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-1.0492846	0.1746	0.00000000187	-	27602958_smoking_packyears_lung_squamous_cell
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.070279	0.0116909	0.000000001882339	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07382156	chr1:2085526	1	2085526	PRKCZ	South shelf	-0.00065	0.00011	0.0000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	2	0.327	0.0000000019	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	0.0013	None	0.0000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.320335	0.0534017	0.000000002030093	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0494553	0.00824647	0.000000002055338	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19257562	chr1:2043853	1	2043853	PRKCZ	North shelf	0.0019	None	0.0000000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0494172	0.00824648	0.000000002114595	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16269144	chr1:2003326	1	2003326	PRKCZ	North shore	0.0013	None	0.0000000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-	-	0.00000000224	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0493245	0.00824652	0.000000002265835	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	0.0047	None	0.0000000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22366001	chr1:2066006	1	2066006	PRKCZ	North shore	-0.0012	0.00021	0.0000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0493026	0.00824653	0.000000002303115	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0492875	0.00824654	0.000000002329047	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0492513	0.00824655	0.000000002392648	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0491877	0.00824658	0.000000002508462	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0490809	0.00824662	0.00000000271526	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.224968	0.0378296	0.000000002785988	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12764620	chr1:2025796	1	2025796	PRKCZ	Island	-0.01119	0.00179	0.0000000028	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.049035	0.00824664	0.000000002809236	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0489962	0.00824666	0.000000002890941	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10313879	chr1:2100435	1	2100435	PRKCZ	Open sea	-0.00015	0.000024	0.0000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0810386	0.0136465	0.000000002942733	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.054167	0.00912438	0.000000002977144	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	-0.011	0.0018	0.000000003	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26221719	chr1:2000462	1	2000462	PRKCZ	Open sea	0.0066	0.00106	0.0000000033	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg26252027	chr1:2012218	1	2012218	PRKCZ	Open sea	-1.635575	0.2766	0.00000000338	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03777518	chr1:2045682	1	2045682	PRKCZ	North shore	0.0047	None	0.0000000034	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0534809	0.00904413	0.000000003427317	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.04874	0.00824676	0.000000003492807	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14255243	chr1:2010660	1	2010660	PRKCZ	Open sea	0.0011	None	0.0000000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24604214	chr1:2092394	1	2092394	PRKCZ	Open sea	0.0011	None	0.0000000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0547128	0.00926804	0.000000003639948	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.04864	0.0082468	0.000000003759117	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0486397	0.0082468	0.000000003760164	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12601506	chr1:2017918	1	2017918	PRKCZ	Open sea	-0.205277	0.0348194	0.000000003802099	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0486112	0.00824681	0.000000003839569	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15033013	chr1:2082458	1	2082458	PRKCZ	Island	-0.0091	0.0016	0.0000000039	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	1.4	0.236	0.0000000039	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.10909	0.0185	0.00000000407	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.193003	0.032815	0.000000004139232	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0539887	0.00918633	0.000000004266486	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0484607	0.00824687	0.000000004287693	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.18862	0.0321	0.00000000434	-	25650246_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18803110	chr1:2057439	1	2057439	PRKCZ	Open sea	-0.00055	0.000093	0.0000000044	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.048423	0.00824689	0.00000000440741	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.19875	0.0338717	0.000000004494779	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg22712840	chr1:2026193	1	2026193	PRKCZ	Island	-1.482155	0.2528	0.00000000457	-	27105112_hiv_infection_discovery
Battram T	GEO	24603599	2020-09-15	Progressive supranuclear palsy	Orphanet_683	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53740	None	DNA methylation	Progressive supranuclear palsy	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	236	1	Geriatrics	Both	Unclear	cg08484080	chr1:1986139	1	1986139	PRKCZ	South shelf	-0.0534	0.00873	0.0000000046	None	24603599_Battram-T_progressive_supranuclear_palsy_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53740
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0517283	0.00883207	0.000000004817638	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-	-	0.00000000482	-	26857698_primary_sjogrens_syndrome_whole_blood
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01970427	chr1:2006896	1	2006896	PRKCZ	South shore	0.0011	None	0.000000005	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	0.00074	0.00013	0.000000005	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	-0.0482493	0.00824696	0.000000005003508	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.048223	0.00824697	0.000000005100632	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12085265	chr1:2014628	1	2014628	PRKCZ	Open sea	0.0038	None	0.0000000052	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.284458	0.0486981	0.000000005273728	None	39706196_Hannah-M.-Smith_body_fat_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-2.3	0.395	0.0000000053	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0012	0.00021	0.0000000055	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0481061	0.00824701	0.00000000555329	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0480912	0.00824702	0.000000005613839	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22332339	chr1:2003605	1	2003605	PRKCZ	North shore	0.0061	None	0.0000000057	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0480532	0.00824703	0.000000005771266	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.00062636	0.00010686	0.00000000611	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.001	0.00017	0.0000000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.007	0.0012	0.0000000064	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15575834	chr1:2099845	1	2099845	PRKCZ	Open sea	0.0011	None	0.0000000064	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-	-	0.00000000663	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0478609	0.00824711	0.000000006634177	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	0.0478324	0.00824712	0.000000006772392	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	0.0022	None	0.0000000069	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0477991	0.00824713	0.000000006937632	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0477719	0.00824714	0.000000007074946	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0052	9e-04	0.0000000072	-	27651444_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.00521	0.0009	0.0000000072	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00328210	chr1:1993016	1	1993016	PRKCZ	South shore	-0.00063	0.00011	0.0000000073	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0477259	0.00824716	0.000000007314006	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27251463	chr1:2075829	1	2075829	PRKCZ	Open sea	-0.202063	0.0349319	0.000000007393198	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0476865	0.00824718	0.000000007524852	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0476786	0.00824718	0.000000007567713	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-1.4	0.243	0.0000000076	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0476604	0.00824719	0.000000007667679	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0817876	0.0141584	0.000000007776437	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0475819	0.00824722	0.000000008113721	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0474968	0.00824725	0.000000008625763	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09225489	chr1:2099891	1	2099891	PRKCZ	Open sea	0.0027	None	0.0000000087	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.368713	0.0640584	0.000000008757384	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0474725	0.00824726	0.000000008777461	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03599988	chr1:2045413	1	2045413	PRKCZ	North shore	0.004	None	0.000000009	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	0.0014	None	0.0000000091	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg15481172	chr1:2059086	1	2059086	PRKCZ	Open sea	-0.00091654	0.00015822	0.00000000914	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0473973	0.00824729	0.000000009263946	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.00078	0.00014	0.0000000093	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0473776	0.0082473	0.000000009395209	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg04349178	chr1:2026224	1	2026224	PRKCZ	Island	-2.007578	0.3513	0.0000000109	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.0470836	0.00824741	0.00000001159162	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0470712	0.00824742	0.00000001169426	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01164686	chr1:2024593	1	2024593	PRKCZ	North shore	0.254758	0.0446451	0.00000001173459	None	39706196_Hannah-M.-Smith_bmi_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-1.53	0.268	0.000000012	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0059	0.00097	0.000000012	None	33564054_Kashima-K_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	-0.00098	0.00017	0.000000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0470344	0.00824743	0.00000001200433	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0470026	0.00824745	0.00000001227912	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.046983	0.00824745	0.00000001245173	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0469328	0.00824747	0.00000001290394	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0469086	0.00824748	0.00000001312716	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.046859	0.0082475	0.00000001359739	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.046799	0.00824752	0.00000001418851	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.184164	0.0324707	0.00000001436331	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.046752	0.00824754	0.00000001466783	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0467408	0.00824755	0.0000000147848	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.09801	0.0173	0.0000000148	-	25650246_gestational_age
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-0.0095	0.00161	0.000000015	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0609972	0.0107828	0.00000001570073	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.00056677	9.95e-05	0.000000016	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.043	0.00694	0.000000016	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0466198	0.00824759	0.00000001610482	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0465644	0.00824762	0.00000001674644	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	CD19+ B cells	Table S6	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	CD19+ B cells	-	71	1	-	Both	European	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	-	-	0.0000000169	-	26857698_primary_sjogrens_syndrome_cd19_b_cells
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-	-	0.0000000169	-	26500701_sex_kora_f4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03959306	chr1:2004968	1	2004968	PRKCZ	North shore	0.0051	None	0.000000017	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	main	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	0.00969	0.00172	0.000000017	None	33279932_Li-M_schizophrenia_main
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.047	0.00832	0.000000017	None	Robert-F-Hillary_Incident_COPD_Basic_model
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	0.12355	0.0219	0.0000000171	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0465224	0.00824763	0.00000001724901	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.046478	0.00824765	0.00000001779649	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0464697	0.00824765	0.00000001790081	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	-0.001	0.00019	0.000000018	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01917640	chr1:2009349	1	2009349	PRKCZ	South shelf	-0.0464306	0.00824767	0.00000001839935	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0464226	0.00824767	0.00000001850361	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08064286	chr1:2092066	1	2092066	PRKCZ	Open sea	0.0464061	0.00824768	0.00000001871999	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	0.0463237	0.00824771	0.00000001983412	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27403569	chr1:2075692	1	2075692	PRKCZ	Open sea	-0.210906	0.037563	0.000000019974	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20153240	chr1:2016789	1	2016789	PRKCZ	Open sea	0.0041	None	0.00000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0462863	0.00824772	0.00000002036094	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0462429	0.00824774	0.00000002098885	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.0462045	0.00824775	0.00000002156078	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0462042	0.00824775	0.00000002156534	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	-0.0461874	0.00824776	0.00000002182097	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg22712840	chr1:2026193	1	2026193	PRKCZ	Island	-0.00021503	3.81e-05	0.0000000219	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	-0.01485	0.00254	0.000000022	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0461741	0.00824777	0.00000002202504	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.108358	0.0193566	0.00000002207143	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	0.0052	None	0.000000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0460871	0.0082478	0.00000002340437	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0460855	0.0082478	0.00000002343056	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0591587	0.0105881	0.00000002347745	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.0460744	0.0082478	0.00000002361288	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.060277	0.0107911	0.00000002367563	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0460575	0.00824781	0.00000002389338	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08651178	chr1:2035295	1	2035295	PRKCZ	North shelf	-0.01201	0.00206	0.000000024	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0460363	0.00824782	0.0000000242494	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0044	8e-04	0.0000000247	-	25935004_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0460074	0.00824783	0.00000002474235	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.046005	0.00824783	0.00000002478326	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24054683	chr1:2085751	1	2085751	PRKCZ	South shelf	0.0038	None	0.000000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14418633	chr1:2005489	1	2005489	PRKCZ	Island	-0.00031	0.000056	0.000000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.038	0.00633	0.000000026	None	32795589_Kyung-WK_atopy_discovery
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.00076543	0.00013655	0.0000000264	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0459061	0.00824787	0.00000002654985	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0458992	0.00824787	0.00000002667741	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0458946	0.00824787	0.00000002676361	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0458919	0.00824787	0.00000002681292	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09322616	chr1:2040400	1	2040400	PRKCZ	North shore	-0.00097	0.00017	0.000000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18269141	chr1:2063966	1	2063966	PRKCZ	Island	0.02	0.0035	0.000000027	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0458595	0.00824788	0.00000002742483	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0458408	0.00824789	0.0000000277833	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24776480	chr1:2066446	1	2066446	PRKCZ	Island	0.0014	None	0.000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	-0.0457599	0.00824792	0.00000002938784	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.045732	0.00824793	0.00000002996161	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0457142	0.00824794	0.00000003033272	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0457088	0.00824794	0.00000003044638	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	CD19+ B cells	Table S6	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	CD19+ B cells	-	71	1	-	Both	European	cg19257562	chr1:2043853	1	2043853	PRKCZ	North shelf	-	-	0.0000000306	-	26857698_primary_sjogrens_syndrome_cd19_b_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25727019	chr1:2100365	1	2100365	PRKCZ	Open sea	-0.01057	0.00183	0.000000031	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0488875	0.0088366	0.00000003213062	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0018	0.00033	0.000000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0455634	0.008248	0.00000003366558	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0455257	0.00824801	0.00000003455381	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	0.0455247	0.00824801	0.00000003457842	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0454683	0.00824803	0.00000003594961	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg13387826	chr1:2005260	1	2005260	PRKCZ	Island	-0.00404	7e-04	0.0000000373	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0454033	0.00824806	0.00000003759428	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21137823	chr1:1981270	1	1981270	PRKCZ	Island	0.02053	0.00358	0.000000038	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0453332	0.00824808	0.00000003945079	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	-1.389288	0.2529	0.0000000396	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03732007	chr1:2071316	1	2071316	PRKCZ	Open sea	-0.0012	0.00021	0.00000004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-	-	0.00000004	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0453039	0.00824809	0.00000004025453	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-	-	0.0000000403	-	26857698_primary_sjogrens_syndrome_whole_blood
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.361227	0.065774	0.00000004031529	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0452979	0.0082481	0.00000004041894	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0452923	0.0082481	0.00000004057645	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	-0.0012	0.00021	0.000000041	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0452766	0.0082481	0.00000004101567	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0452594	0.00824811	0.00000004150198	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0452516	0.00824811	0.00000004172472	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0590677	0.0107681	0.00000004192657	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0056	0.00096	0.000000042	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	-0.045231	0.00824812	0.00000004231817	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg15481172	chr1:2059086	1	2059086	PRKCZ	Open sea	-0.0007626	0.00013823	0.0000000433	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	1.2	0.215	0.000000044	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.178458	0.0325916	0.00000004421777	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0512629	0.00936447	0.00000004467365	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0856041	0.0156392	0.00000004479555	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0451424	0.00824815	0.00000004496725	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.034	0.00569	0.000000045	None	32795589_Kyung-WK_atopy_discovery
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg16653138	chr1:2005180	1	2005180	PRKCZ	Island	0.039	0.007	0.000000045	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0451305	0.00824816	0.00000004533411	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.045121	0.00824816	0.0000000456282	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-	-	0.0000000457	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0450985	0.00824817	0.00000004633858	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	-0.279609	0.0511514	0.00000004655535	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg21221161	chr1:1999183	1	1999183	PRKCZ	Open sea	-0.02208	0.004	0.0000000466	-	23334450_rheumatoid_arthritis
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	adjusted for cell composition	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg00443516	chr1:2061836	1	2061836	PRKCZ	North shore	None	None	0.000000047	None	33279932_Li-M_schizophrenia_adjusted_for_cell_composition
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	-0.017	0.00291	0.000000047	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0752075	0.0137741	0.00000004837478	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0450218	0.0082482	0.00000004882887	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg02840585	chr1:2090953	1	2090953	PRKCZ	Open sea	-	-	0.0000000489	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0450186	0.0082482	0.00000004893622	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01907016	chr1:1985500	1	1985500	PRKCZ	South shelf	-0.00075	0.00014	0.000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01164686	chr1:2024593	1	2024593	PRKCZ	North shore	-0.237409	0.0435044	0.00000004902373	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0449966	0.00824821	0.00000004967633	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	0.0449801	0.00824821	0.00000005023842	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Knijnenburg	None	30833390	Mar 19, 2019	very early preterm birth (<28 weeks)	EFO_0003917	discovery	Supplementary dataset 10	DNA methylation	very early preterm birth (<28 weeks)	Age, Ancestry (genomic PCs), time since birth	M values	None	Illumina HumanMethylation450	whole blood	None	784	1	Adults	Females	Admixed	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.39	0.07	0.000000051	None	30833390_Knijnenburg_very_early_preterm_birth___28_weeks__discovery
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	-0.018	0.00308	0.000000051	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0449549	0.00824822	0.00000005111086	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	-0.12815	0.0235	0.0000000512	-	25650246_gestational_age
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg24054683	chr1:2085751	1	2085751	PRKCZ	South shelf	-1.465116	0.2691	0.000000052	-	27105112_hiv_infection_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.031	0.00573	0.000000053	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	0.04488	0.00824825	0.00000005378609	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0585484	0.010767	0.00000005481701	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0448497	0.00824826	0.00000005490616	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.176665	0.0324984	0.0000000551916	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0448369	0.00824827	0.00000005538653	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.044817	0.00824828	0.00000005614022	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0448026	0.00824828	0.00000005669152	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.044802	0.00824828	0.00000005671717	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0447959	0.00824828	0.00000005695101	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0447575	0.0082483	0.00000005845614	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0447551	0.0082483	0.00000005855108	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	-0.00093	0.00017	0.000000059	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0492988	0.00909264	0.00000005992267	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05706173	chr1:2104310	1	2104310	PRKCZ	Open sea	0.005	None	0.00000006	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0787603	0.0145279	0.00000006009508	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-1.02	0.189	0.000000061	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.00091982	0.00016872	0.000000062	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0015	None	0.000000062	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0447183	0.00826044	0.00000006275851	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0446513	0.00824834	0.00000006282041	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08064286	chr1:2092066	1	2092066	PRKCZ	Open sea	0.0446488	0.00824834	0.00000006292921	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24776480	chr1:2066446	1	2066446	PRKCZ	Island	-0.0011	0.00021	0.000000063	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	0.00033	None	0.000000064	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23844174	chr1:2064819	1	2064819	PRKCZ	Island	-0.00015	0.000028	0.000000064	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	24603599	2020-09-15	Frontotemporal dementia	Orphanet_282	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53740	None	DNA methylation	Frontotemporal dementia	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	314	1	Geriatrics	Both	Unclear	cg08484080	chr1:1986139	1	1986139	PRKCZ	South shelf	-0.0476	0.00859	0.000000067	None	24603599_Battram-T_frontotemporal_dementia_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53740
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0551486	0.0102149	0.00000006811755	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0445263	0.00824838	0.00000006836428	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0445132	0.00824839	0.00000006897227	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0444993	0.00824839	0.00000006962391	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.290876	0.053944	0.00000007052035	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02300356	chr1:2027983	1	2027983	PRKCZ	South shore	0.0015	None	0.000000071	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	random effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.71	0.132	0.000000071	None	33646943_Hannon-E_schizophrenia_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.044441	0.00824841	0.00000007241687	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0444329	0.00824842	0.00000007281341	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	-0.001	0.00019	0.000000074	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0443786	0.00824844	0.0000000755267	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22366001	chr1:2066006	1	2066006	PRKCZ	North shore	0.0014	None	0.000000077	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0443499	0.00824845	0.0000000770004	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-0.0443426	0.00824845	0.00000007738018	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.044324	0.00824846	0.00000007835629	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0597687	0.0111274	0.00000007936959	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-	-	0.0000000799	-	26857698_primary_sjogrens_syndrome_whole_blood
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-2	0.379	0.00000008	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0442832	0.00824847	0.00000008053499	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0442666	0.00824848	0.00000008143558	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Panni T	-	26731791	2016-07-01	Air pollution exposure	EFO_0008255	28-day trailing average particle matter concentration	Additional file 1	DNA methylation	Air pollution exposure	Age, sex, smoking, income, alcohol consumption, body mass index, cell counts and technical covariates	Beta values	mug/m3	Illumina HumanMethylation450	Whole blood	Regression coefficients per 10-muy/m3 increase in paricle matter polution	2956	3	62.2	Both	European	cg19870743	chr1:2097158	1	2097158	PRKCZ	Open sea	0.00344	0.000641	0.0000000815	-	26731791_air_pollution_exposure_28day_trailing_average_particle_matter_concentration
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0578083	0.0107757	0.00000008231422	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19412821	chr1:2104786	1	2104786	PRKCZ	Open sea	-0.01034	0.0019	0.0000000824	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0764368	0.0142538	0.00000008329161	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0468085	0.0087328	0.0000000844423	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	0.01767	0.00317	0.000000086	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0475526	0.00888294	0.00000008768999	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0441539	0.00824852	0.00000008783335	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.044148	0.00824852	0.00000008818092	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0441414	0.00824852	0.00000008857414	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-0.0441348	0.00824853	0.0000000889659	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.178733	0.0334153	0.00000008964579	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0774569	0.0144821	0.00000009004172	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Aslibekyan S	-	25075435	2014-11-01	Sunlight duration	OMIT_0014339	-	Table 2	DNA methylation	Sunlight duration	Age, sex, smoking, study centre, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.004	7e-04	0.000000092	-	25075435_sunlight_duration
Aslibekyan S	-	25075435	2014-11-01	Sunlight duration	OMIT_0014339	Adjusted for vitamin D intake	Table 2	DNA methylation	Sunlight duration	Age, sex, smoking, study centre, vitamin D intake, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.004	7e-04	0.000000092	-	25075435_sunlight_duration_adjusted_for_vitamin_d_intake
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0440557	0.00824855	0.00000009380256	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0081	0.0015	0.000000095	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.044002	0.00824857	0.00000009723091	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.042	0.00781	0.000000099	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0439622	0.00824859	0.00000009984956	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0049	0.00087	0.0000001	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0439325	0.0082486	0.0000001018463	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	-1.255973	0.2359	0.000000102	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0439275	0.0082486	0.0000001021906	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0460523	0.008648	0.0000001023316	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0840318	0.0157808	0.0000001024694	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0439178	0.00824861	0.0000001028512	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.09132	0.0172	0.000000104	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0474065	0.00891287	0.0000001059404	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0593115	0.0111517	0.0000001061052	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0438575	0.00824863	0.000000107073	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Li M	None	33279932	2020-12-14	Schizophrenia	EFO_0000692	adjusted for cell composition	Table 1	DNA methylation	Schizophrenia	age, sex, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	999	None	Adults	Both	East Asian	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	None	None	0.00000011	None	33279932_Li-M_schizophrenia_adjusted_for_cell_composition
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	2	0.384	0.00000011	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13480549	chr1:2058790	1	2058790	PRKCZ	Open sea	0.00056	None	0.00000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0437484	0.00824867	0.0000001151336	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0570726	0.010763	0.0000001157831	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0437238	0.00824868	0.0000001170306	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0437012	0.00824868	0.0000001187923	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.9499692	0.1794	0.000000119	-	27602958_smoking_packyears_replication
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	0.004	0.00072	0.00000012	None	33564054_Kashima-K_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	0.00084	None	0.00000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.012	0.0022	0.00000012	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0436673	0.0082487	0.0000001215025	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0436361	0.00824871	0.0000001240374	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0663752	0.0125472	0.000000124043	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0436233	0.00824871	0.0000001250921	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0436001	0.00824872	0.0000001270354	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	-0.243776	0.0461302	0.0000001274817	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.043591	0.00824872	0.0000001277979	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0435876	0.00824872	0.0000001280859	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	0.0435744	0.00824873	0.0000001292147	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	0.0037	None	0.00000013	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05802244	chr1:2011082	1	2011082	PRKCZ	Open sea	-0.01072	0.00195	0.00000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0435527	0.00824874	0.000000131085	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0435072	0.00824875	0.0000001350856	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08000672	chr1:2012434	1	2012434	PRKCZ	Open sea	0.0044	None	0.00000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22332339	chr1:2003605	1	2003605	PRKCZ	North shore	-0.0078	0.0015	0.00000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0434375	0.00824878	0.0000001414537	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0434365	0.00824878	0.0000001415399	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.171206	0.0325193	0.0000001420451	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0434069	0.00824879	0.0000001443344	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0434066	0.00824879	0.000000144362	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0433953	0.00824879	0.0000001454426	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02107558	chr1:2000679	1	2000679	PRKCZ	Open sea	-0.23711	0.0450877	0.0000001465863	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.0437273	0.00831788	0.0000001484646	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0433636	0.0082488	0.000000148511	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0433616	0.00824881	0.0000001487095	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0433013	0.00824883	0.0000001547332	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0432541	0.00824884	0.0000001596142	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.0482703	0.00921312	0.0000001634193	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.0432024	0.00824886	0.0000001651318	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0431852	0.00824887	0.000000167005	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0481938	0.00920629	0.0000001673774	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0754658	0.0144219	0.0000001693369	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0043	8e-04	0.00000017	-	27651444_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.00429	0.00082	0.00000017	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.253444	0.0484508	0.0000001706056	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0627931	0.0120046	0.0000001711509	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0431233	0.00824889	0.0000001739208	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-	-	0.000000174	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.046163	0.0088354	0.0000001767571	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.1037	0.0198533	0.0000001781381	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.0430786	0.00824891	0.0000001790887	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.0430738	0.00824891	0.0000001796506	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.00121254	0.00023079	0.00000018	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0430589	0.00824891	0.0000001814205	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.303688	0.0582055	0.0000001834333	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0430262	0.00824893	0.0000001853345	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.043016	0.00824893	0.000000186579	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00328210	chr1:1993016	1	1993016	PRKCZ	South shore	0.01424	0.00263	0.00000019	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0011	0.0002	0.00000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	-0.00064	0.00012	0.00000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0429774	0.00824894	0.0000001913419	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0463201	0.00889965	0.0000001969259	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0429291	0.00824896	0.0000001974855	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16813816	chr1:2091066	1	2091066	PRKCZ	Open sea	-0.00061	0.00012	0.0000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	HRAS protein levels (SeqId = 18900-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HRAS protein levels (SeqId = 18900-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GTPase HRas	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.73	0.14	0.0000002	None	Gadd-DA_hras_protein_levels__seqid___18900-37__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.000047	0.0000091	0.0000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0456115	0.00877081	0.0000002015658	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.289506	0.0556844	0.0000002025832	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.181113	0.0348466	0.0000002043338	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0428687	0.00824898	0.0000002054148	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.042846	0.00824899	0.0000002084745	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22174681	chr1:2013930	1	2013930	PRKCZ	Open sea	0.01574	0.00293	0.00000021	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.0428211	0.008249	0.000000211891	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0428044	0.008249	0.000000214195	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.185212	0.0357	0.000000216	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0892654	0.0172092	0.0000002164558	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0427668	0.00824902	0.000000219503	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.0066	0.0013	0.00000022	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27264322	chr1:1992046	1	1992046	PRKCZ	South shore	-0.00071	0.00014	0.00000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.052	0.01013	0.00000022	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0515112	0.00994069	0.0000002226113	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.274739	0.0530474	0.0000002254279	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0427253	0.00824903	0.0000002255101	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0427073	0.00824904	0.000000228156	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-0.0007	0.00013	0.00000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24475758	chr1:1998863	1	1998863	PRKCZ	Open sea	0.01707	0.00318	0.00000023	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0426912	0.00824904	0.0000002305588	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04100007	chr1:2075739	1	2075739	PRKCZ	Open sea	-0.174252	0.0336833	0.0000002325087	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0426758	0.00824905	0.0000002328715	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.042671	0.00824905	0.0000002335972	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0426668	0.00824905	0.0000002342444	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19870743	chr1:2097158	1	2097158	PRKCZ	Open sea	-0.217686	0.0421123	0.0000002376006	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0426318	0.00824907	0.0000002396248	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0063	0.0012	0.00000024	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.168271	0.0325755	0.0000002423742	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0426014	0.00824908	0.0000002443879	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0425824	0.00824908	0.0000002474221	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM8B protein levels (SeqId = 12742-160)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM8B protein levels (SeqId = 12742-160)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 8B	774	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-1.526	0.296	0.00000025	None	Gadd-DA_tmem8b_protein_levels__seqid___12742-160__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	0.0041	0.0008	0.00000025	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16269144	chr1:2003326	1	2003326	PRKCZ	North shore	-0.0063	0.0012	0.00000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	0.0425591	0.00824909	0.0000002511784	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0753639	0.0146179	0.0000002561437	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	0.0425287	0.0082491	0.0000002561639	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13591369	chr1:2005564	1	2005564	PRKCZ	Island	-0.0057	0.0011	0.00000026	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0754266	0.0146454	0.0000002635816	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0015	None	0.00000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg24604214	chr1:2092394	1	2092394	PRKCZ	Open sea	-1.59	0.31	0.00000027	4804	31197173_Liu-J_fasting_glucose_base
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg06717814	chr1:2038593	1	2038593	PRKCZ	Island	-0.1219785	0.0237305	0.0000002745	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11699150	chr1:2002329	1	2002329	PRKCZ	North shelf	-0.192181	0.0373784	0.0000002753584	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	-0.0423937	0.00824915	0.0000002795194	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-3.75	0.721	0.00000029	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.144277	0.0281202	0.0000002917557	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0423255	0.00824917	0.0000002920823	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0423153	0.00824918	0.0000002939987	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22627876	chr1:1988808	1	1988808	PRKCZ	North shore	-0.00756	0.00142	0.0000003	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.101825	0.0198774	0.0000003051043	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0695604	0.0135822	0.0000003070562	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPRE2 protein levels (SeqId = 16856-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPRE2 protein levels (SeqId = 16856-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Microtubule-associated protein RP/EB family member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.72	0.14	0.00000031	None	Gadd-DA_mapre2_protein_levels__seqid___16856-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.0422302	0.00824921	0.0000003105456	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0422075	0.00824921	0.0000003151036	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0693874	0.0135674	0.0000003189319	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.042187	0.00824922	0.0000003192739	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24447775	chr1:1992534	1	1992534	PRKCZ	South shore	0.0013	None	0.00000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0421616	0.00824923	0.000000324526	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0421508	0.00824923	0.0000003267881	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04871460	chr1:1991521	1	1991521	PRKCZ	South shore	-0.0011	0.00021	0.00000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23803603	chr1:2058230	1	2058230	PRKCZ	Open sea	-0.00092	0.00018	0.00000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.266695	0.0522204	0.0000003306014	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.045269	0.00886625	0.0000003335945	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0421004	0.00824925	0.0000003375174	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0420921	0.00824925	0.000000339329	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-1.7	0.34	0.00000034	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19759051	chr1:2030817	1	2030817	PRKCZ	Open sea	-0.00056	0.00011	0.00000034	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0420751	0.00824926	0.0000003430353	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0420623	0.00824926	0.0000003458555	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0456748	0.00895963	0.0000003478197	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Yang BZ	-	23332324	2013-02-01	Child abuse	-	-	Appendix B	DNA methylation	Child abuse	Sex, age and ethnicity	Beta values	-	Illumina HumanMethylation450	Saliva	-	192	1	10	Both	European,African,Admixed,Other	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	-	-	0.000000348	-	23332324_child_abuse
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-2.88	0.558	0.00000035	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15115072	chr1:2002722	1	2002722	PRKCZ	North shelf	-0.01338	0.00254	0.00000035	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0420058	0.00824928	0.0000003585911	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.077	0.0152	0.00000036	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.0419684	0.0082493	0.0000003672598	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05802244	chr1:2011082	1	2011082	PRKCZ	Open sea	-0.00091	0.00018	0.00000037	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAP1 protein levels (SeqId = 11649-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAP1 protein levels (SeqId = 11649-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal membrane-associated protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.71	0.14	0.00000037	None	Gadd-DA_smap1_protein_levels__seqid___11649-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0876781	0.0172415	0.0000003715971	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0419474	0.0082493	0.0000003722333	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.18349	0.0360885	0.0000003725475	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.044769	0.00880506	0.000000373217	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0419342	0.00824931	0.000000375388	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11699150	chr1:2002329	1	2002329	PRKCZ	North shelf	-0.01126	0.00214	0.00000038	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.02989	0.00568	0.00000038	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0419106	0.00824932	0.0000003810892	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0418847	0.00824933	0.0000003874326	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0418765	0.00824933	0.0000003894617	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg23276504	chr1:2035462	1	2035462	PRKCZ	North shelf	-1.238561	0.2443	0.000000397	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0740527	0.0145996	0.0000003979453	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	0.0027	None	0.0000004	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.1451595	0.0286415	0.0000004017	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.00103473	0.0002029	0.000000402	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0418199	0.00824935	0.0000004037512	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0418198	0.00824935	0.000000403798	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	0.0004	0.000078	0.00000041	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	-0.0429832	0.00848668	0.0000004138203	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0417748	0.00824936	0.0000004155264	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.00099276	0.00019496	0.000000418	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0417624	0.00824937	0.0000004188163	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0417449	0.00824937	0.0000004234955	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0417319	0.00824938	0.0000004270019	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0609434	0.0120494	0.0000004292804	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11781622	chr1:2041072	1	2041072	PRKCZ	Island	0.001	None	0.00000043	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	0.0045	None	0.00000044	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0416518	0.00824941	0.0000004492952	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0061	0.0012	0.00000046	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0415994	0.00824942	0.0000004644732	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.0415923	0.00824943	0.000000466584	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0415868	0.00824943	0.0000004682015	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.044462	0.00882535	0.0000004760605	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0415591	0.00824944	0.0000004764726	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0434455	0.00862517	0.0000004783465	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	5.9	None	0.00000048	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.0415362	0.00824945	0.0000004834447	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.041535	0.00824945	0.0000004838172	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0434854	0.00863993	0.0000004883973	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0415112	0.00824945	0.0000004911556	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0992746	0.0197347	0.000000495112	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-0.0415672	0.00826971	0.0000005055492	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0464857	0.00925042	0.0000005087071	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0414332	0.00824948	0.0000005159758	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0414201	0.00824949	0.0000005202591	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0414102	0.00824949	0.0000005235233	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.322362	0.0642401	0.0000005268385	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0413758	0.0082495	0.0000005349976	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0413716	0.0082495	0.0000005364286	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.041367	0.0082495	0.0000005379766	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Kazmi N	PACE	31230546	2019-06-24	Preeclampsia	EFO_0000668	Meta analysis unadjusted model	Table S5	DNA methylation	Preeclampsia	Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	3460	6	Infants	Both	Unclear	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0536	0.0107	0.00000054	None	31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0413151	0.00824952	0.0000005558357	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.246841	0.0493308	0.0000005676607	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0429093	0.00857478	0.0000005676784	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0412578	0.00824954	0.0000005762669	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.00072	0.00014	0.00000058	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Dunn E	ARIES	30905381	2019-01-21	Caregiver and physical or emotional abuse	None	Adversity was experienced between ages 8 months and 6 years old	Table S3	DNA methylation	Caregiver and physical or emotional abuse	Ancestry (other), birth weight, maternal age, socioeconomic position, number of previous maternal pregnancies	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	774	1	Children	Both	Unclear	cg08000672	chr1:2012434	1	2012434	PRKCZ	Open sea	None	None	0.00000058	middle childhood (age 6)	30905381_Dunn-E_caregiver_and_physical_or_emotional_abuse_adversity_was_experienced_between_ages_8_months_and_6_years_old
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0412303	0.00824955	0.0000005863202	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0412197	0.00824955	0.0000005902089	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0412158	0.00824956	0.0000005916856	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0412059	0.00824956	0.0000005953788	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg24604214	chr1:2092394	1	2092394	PRKCZ	Open sea	-1.5	0.3	0.0000006	4804	31197173_Liu-J_fasting_glucose_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0487675	0.00978826	0.0000006356801	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.2522	0.0506335	0.0000006389922	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0410907	0.0082496	0.0000006399697	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02840585	chr1:2090953	1	2090953	PRKCZ	Open sea	0.0004298	8.58e-05	0.000000643	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	ARHGEF1 protein levels (SeqId = 13976-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARHGEF1 protein levels (SeqId = 13976-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho guanine nucleotide exchange factor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.7	0.14	0.00000065	None	Gadd-DA_arhgef1_protein_levels__seqid___13976-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	-0.0410553	0.00824961	0.000000654321	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19900677	chr1:1999533	1	1999533	PRKCZ	Open sea	-0.00078	0.00016	0.00000066	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0410346	0.00824962	0.0000006628735	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0410298	0.00824962	0.0000006648426	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	0.148425	0.0298562	0.0000006709728	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0410052	0.00824963	0.0000006751548	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0409965	0.00824963	0.0000006788204	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MRPL21 protein levels (SeqId = 8942-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRPL21 protein levels (SeqId = 8942-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 39S ribosomal protein L21, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.7	0.14	0.00000068	None	Gadd-DA_mrpl21_protein_levels__seqid___8942-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0527291	0.0106169	0.0000006893744	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	0.0409669	0.00824964	0.000000691516	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0409622	0.00824964	0.0000006935292	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0409529	0.00824964	0.0000006975777	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0429244	0.00864696	0.0000006979277	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	-0.0409252	0.00824965	0.0000007097372	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg07382156	chr1:2085526	1	2085526	PRKCZ	South shelf	-1.275228	0.2572	0.000000712	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0409141	0.00824966	0.0000007146797	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	-0.241566	0.0487513	0.0000007295201	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0408729	0.00824967	0.0000007332854	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0408611	0.00824968	0.000000738683	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0053	None	0.00000074	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0408555	0.00824968	0.0000007412787	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0408426	0.00824968	0.0000007472839	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.12622	0.0254997	0.0000007495855	None	39706196_Hannah-M.-Smith_bmi_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.25	0.0504	0.00000075	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.040829	0.00824969	0.0000007536289	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0408274	0.00824969	0.0000007543616	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0431193	0.00871372	0.0000007564404	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0407907	0.0082497	0.0000007717986	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0407883	0.0082497	0.0000007729678	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14417954	chr1:1981217	1	1981217	PRKCZ	North shore	0.0018	None	0.00000078	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.178729	0.0361727	0.0000007845426	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.258589	0.0523425	0.0000007872357	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0407497	0.00824971	0.0000007917145	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0061	None	0.0000008	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0766133	0.0155197	0.0000008040497	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.040723	0.00824972	0.0000008049839	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0407183	0.00824972	0.0000008073443	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	0.154253	0.0312557	0.0000008081596	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01164686	chr1:2024593	1	2024593	PRKCZ	North shore	0.220069	0.0446209	0.0000008215986	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0406756	0.00824974	0.0000008290099	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	0.0406335	0.00824975	0.0000008509567	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14778173	chr1:2103645	1	2103645	PRKCZ	Open sea	-0.172231	0.0349827	0.0000008583514	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04349178	chr1:2026224	1	2026224	PRKCZ	Island	-0.00071	0.00014	0.00000086	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-0.350604	0.0713	0.000000863	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0432297	0.00878298	0.0000008660232	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.040604	0.00824976	0.0000008666468	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23048698	chr1:2109816	1	2109816	PRKCZ	Open sea	-0.00965	0.0019	0.00000088	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.040573	0.00824977	0.0000008834601	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.321221	0.0653616	0.0000008981449	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	0.0405291	0.00824979	0.0000009078146	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0526317	0.0107177	0.0000009172531	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.192048	0.0391284	0.0000009277544	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0404934	0.0082498	0.0000009280458	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06888836	chr1:2074268	1	2074268	PRKCZ	Open sea	0.0015	None	0.00000093	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14255243	chr1:2010660	1	2010660	PRKCZ	Open sea	0.0033	None	0.00000093	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PKN1 protein levels (SeqId = 12562-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PKN1 protein levels (SeqId = 12562-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase N1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.69	0.14	0.00000093	None	Gadd-DA_pkn1_protein_levels__seqid___12562-1__somascan_protein_measurement
Knijnenburg	None	30833390	Mar 19, 2019	very early preterm birth (<28 weeks)	EFO_0003917	discovery	Supplementary dataset 10	DNA methylation	very early preterm birth (<28 weeks)	Age, Ancestry (genomic PCs), time since birth	M values	None	Illumina HumanMethylation450	whole blood	None	784	1	Adults	Females	Admixed	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.31	0.063	0.00000095	None	30833390_Knijnenburg_very_early_preterm_birth___28_weeks__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0404475	0.00824981	0.0000009547303	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0404265	0.00824982	0.000000967202	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0077	0.0016	0.00000097	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg19906777	chr1:2023482	1	2023482	PRKCZ	North shore	0.0068	0.0013	0.00000098	None	33564054_Kashima-K_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08651178	chr1:2035295	1	2035295	PRKCZ	North shelf	-0.218453	0.0446084	0.0000009807925	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0403923	0.00824983	0.0000009878153	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0403802	0.00824984	0.0000009951846	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DCI protein levels (SeqId = 19367-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DCI protein levels (SeqId = 19367-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Enoyl-CoA delta isomerase 1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.000001	None	Gadd-DA_dci_protein_levels__seqid___19367-34__somascan_protein_measurement
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	5.2	None	0.000001	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0403542	0.00824985	0.000001011272	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0403176	0.00824986	0.000001034324	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	-	-	0.00000105	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0402719	0.00824987	0.000001063792	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.8235049	0.1689	0.00000108	-	27602958_smoking_packyears_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0402183	0.00824989	0.000001099448	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02300356	chr1:2027983	1	2027983	PRKCZ	South shore	0.00043	None	0.0000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0401974	0.0082499	0.000001113598	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.26614	0.0547	0.00000114	None	27105112_hiv_infection_cd4_tcells
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg24447775	chr1:1992534	1	1992534	PRKCZ	South shore	-0.167477	0.0344	0.00000114	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0401582	0.00824991	0.000001140692	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0401567	0.00824991	0.000001141801	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0401427	0.00824992	0.000001151578	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0400854	0.00824994	0.000001192722	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22342249	chr1:2043439	1	2043439	PRKCZ	North shelf	-0.00051	0.00011	0.0000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22128985	chr1:2089384	1	2089384	PRKCZ	Open sea	0.230189	0.0473914	0.000001201056	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.235794	0.048567	0.000001214272	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.066948	0.0137904	0.000001218149	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	0.0400486	0.00824995	0.000001219931	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0400275	0.00824995	0.000001235788	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0400232	0.00824996	0.000001239007	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0756216	0.0155901	0.000001243388	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0399953	0.00824997	0.000001260324	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03754143	chr1:1981548	1	1981548	PRKCZ	Island	0.01143	0.00229	0.0000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15481172	chr1:2059086	1	2059086	PRKCZ	Open sea	0.0062	0.0013	0.0000013	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	BRICD5 protein levels (SeqId = 6612-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BRICD5 protein levels (SeqId = 6612-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BRICHOS domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.0000013	None	Gadd-DA_bricd5_protein_levels__seqid___6612-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0399338	0.00824999	0.000001308482	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0399213	0.00824999	0.000001318511	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.039912	0.00824999	0.000001326017	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0420656	0.00870519	0.000001363689	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11781622	chr1:2041072	1	2041072	PRKCZ	Island	-0.19904	0.0412028	0.000001371408	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0398272	0.00825002	0.000001396295	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0398254	0.00825002	0.000001397858	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17815669	chr1:2003198	1	2003198	PRKCZ	North shore	0.0051	None	0.0000014	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PDIA6 protein levels (SeqId = 5650-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDIA6 protein levels (SeqId = 5650-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase A6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.0000014	None	Gadd-DA_pdia6_protein_levels__seqid___5650-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PLCB1 protein levels (SeqId = 11354-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLCB1 protein levels (SeqId = 11354-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.0000014	None	Gadd-DA_plcb1_protein_levels__seqid___11354-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAD4 protein levels (SeqId = 12022-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAD4 protein levels (SeqId = 12022-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mothers against decapentaplegic homolog 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.0000014	None	Gadd-DA_smad4_protein_levels__seqid___12022-12__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0398125	0.00825556	0.000001431905	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0397783	0.00825004	0.000001438459	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0430231	0.00892343	0.000001440156	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0441802	0.00916778	0.000001456677	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0397511	0.00825005	0.000001462402	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0397418	0.00825005	0.000001470758	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0397406	0.00825005	0.000001471816	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.273658	0.0568217	0.000001475835	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0397209	0.00825006	0.000001489514	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01970427	chr1:2006896	1	2006896	PRKCZ	South shore	-0.00712	0.00143	0.0000015	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02066716	chr1:2112006	1	2112006	PRKCZ	Open sea	-0.0032	0.00065	0.0000015	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12297010	chr1:2096582	1	2096582	PRKCZ	Open sea	0.0036	None	0.0000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SPG20 protein levels (SeqId = 11161-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPG20 protein levels (SeqId = 11161-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Spartin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.68	0.14	0.0000015	None	Gadd-DA_spg20_protein_levels__seqid___11161-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GRAP protein levels (SeqId = 12820-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRAP protein levels (SeqId = 12820-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GRB2-related adapter protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000015	None	Gadd-DA_grap_protein_levels__seqid___12820-1__somascan_protein_measurement
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	0.013	0.0025	0.0000015	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0396828	0.00825007	0.000001524291	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.272366	0.0566467	0.000001535547	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0396648	0.00825007	0.00000154106	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.039662	0.00825007	0.000001543658	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0396516	0.00825008	0.000001553388	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0396514	0.00825008	0.00000155362	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg27449973	chr1:2111912	1	2111912	PRKCZ	Open sea	-0.184396	0.0384	0.00000157	None	27105112_hiv_infection_cd4_tcells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.151839	0.0316139	0.00000157611	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0396107	0.00825009	0.000001592415	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03395993	chr1:2109923	1	2109923	PRKCZ	Open sea	0.0118	0.00238	0.0000016	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Dunn E	ARIES	30905381	2019-01-21	Caregiver and physical or emotional abuse	None	Adversity was experienced between ages 8 months and 6 years old	Table S3	DNA methylation	Caregiver and physical or emotional abuse	Ancestry (other), birth weight, maternal age, socioeconomic position, number of previous maternal pregnancies	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	774	1	Children	Both	Unclear	cg19619416	chr1:1992232	1	1992232	PRKCZ	South shore	None	None	0.0000016	early childhood (age 5)	30905381_Dunn-E_caregiver_and_physical_or_emotional_abuse_adversity_was_experienced_between_ages_8_months_and_6_years_old
Gadd DA	Generation Scotland	35945220	31/07/2022	CHMP2B protein levels (SeqId = 17350-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHMP2B protein levels (SeqId = 17350-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Charged multivesicular body protein 2b	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000016	None	Gadd-DA_chmp2b_protein_levels__seqid___17350-13__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	0.0013	None	0.0000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.077	0.01597	0.0000016	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	-0.0395866	0.0082501	0.000001615778	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0395812	0.0082501	0.000001621112	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0665804	0.0138908	0.000001658156	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0688798	0.0143711	0.000001659548	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.0445806	0.00930271	0.000001665648	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0395049	0.00825013	0.000001697545	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	-0.00089	0.00019	0.0000017	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	COX5A protein levels (SeqId = 18226-148)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COX5A protein levels (SeqId = 18226-148)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytochrome c oxidase subunit 5A, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000017	None	Gadd-DA_cox5a_protein_levels__seqid___18226-148__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0394968	0.00825013	0.000001705861	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.6449169	0.1349	0.00000174	-	27602958_smoking_packyears_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.075447	0.0157853	0.000001773725	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	WSCD2 protein levels (SeqId = 6274-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WSCD2 protein levels (SeqId = 6274-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WSC domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000018	None	Gadd-DA_wscd2_protein_levels__seqid___6274-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GGA1 protein levels (SeqId = 13594-158)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GGA1 protein levels (SeqId = 13594-158)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-binding protein GGA1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000018	None	Gadd-DA_gga1_protein_levels__seqid___13594-158__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HINT2 protein levels (SeqId = 5612-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HINT2 protein levels (SeqId = 5612-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histidine triad nucleotide-binding protein 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000018	None	Gadd-DA_hint2_protein_levels__seqid___5612-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DOK1 protein levels (SeqId = 16831-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DOK1 protein levels (SeqId = 16831-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Docking protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000018	None	Gadd-DA_dok1_protein_levels__seqid___16831-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0434084	0.00908967	0.000001809297	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	0.039777	0.00833056	0.000001815939	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0393824	0.00825017	0.000001827738	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0393798	0.00825017	0.000001830577	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.122304	0.0256307	0.000001843876	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0393647	0.00825017	0.000001847256	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0393567	0.00825017	0.0000018562	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19412821	chr1:2104786	1	2104786	PRKCZ	Open sea	0.0017	None	0.0000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NAPG protein levels (SeqId = 17773-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAPG protein levels (SeqId = 17773-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gamma-soluble NSF attachment protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.0000019	None	Gadd-DA_napg_protein_levels__seqid___17773-26__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27587033	chr1:2006032	1	2006032	PRKCZ	South shore	0.0011	None	0.0000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0393021	0.00825019	0.000001918138	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0392906	0.0082502	0.000001931522	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0392824	0.0082502	0.000001940989	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	-0.0536726	0.0112734	0.000001945054	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0625206	0.0131322	0.000001946085	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0392503	0.00825021	0.000001978851	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0392493	0.00825021	0.000001979998	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	-0.0392464	0.00825021	0.000001983439	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11835265	chr1:2011913	1	2011913	PRKCZ	Open sea	0.0074	None	0.000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ASCC1 protein levels (SeqId = 10647-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASCC1 protein levels (SeqId = 10647-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Activating signal cointegrator 1 complex subunit 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.000002	None	Gadd-DA_ascc1_protein_levels__seqid___10647-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNTB1 protein levels (SeqId = 9078-207)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNTB1 protein levels (SeqId = 9078-207)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1-syntrophin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.000002	None	Gadd-DA_sntb1_protein_levels__seqid___9078-207__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNM2 protein levels (SeqId = 11572-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNM2 protein levels (SeqId = 11572-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dynamin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.000002	None	Gadd-DA_dnm2_protein_levels__seqid___11572-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APP protein levels (SeqId = 3171-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APP protein levels (SeqId = 3171-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-beta precursor protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.67	0.14	0.000002	None	Gadd-DA_app_protein_levels__seqid___3171-57__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24475758	chr1:1998863	1	1998863	PRKCZ	Open sea	0.0079	None	0.000002	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0392264	0.00825022	0.000002007366	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0392198	0.00825022	0.000002015334	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0392166	0.00825022	0.000002019285	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0392153	0.00825022	0.000002020843	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0392129	0.00825022	0.000002023701	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0392051	0.00825022	0.000002033226	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0410175	0.00863272	0.000002039306	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0391913	0.00825023	0.000002050088	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.039182	0.00825023	0.00000206161	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0391545	0.00825024	0.000002095856	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0749292	0.0157886	0.000002096615	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	YWHAB protein levels (SeqId = 14156-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	YWHAB protein levels (SeqId = 14156-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 14-3-3 protein beta/alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000021	None	Gadd-DA_ywhab_protein_levels__seqid___14156-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC10 protein levels (SeqId = 8297-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC10 protein levels (SeqId = 8297-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily C member 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000021	None	Gadd-DA_dnajc10_protein_levels__seqid___8297-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COPS2 protein levels (SeqId = 14029-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COPS2 protein levels (SeqId = 14029-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COP9 signalosome complex subunit 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000021	None	Gadd-DA_cops2_protein_levels__seqid___14029-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IRF3 protein levels (SeqId = 17151-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IRF3 protein levels (SeqId = 17151-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon regulatory factor 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000021	None	Gadd-DA_irf3_protein_levels__seqid___17151-84__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.0391489	0.00825024	0.000002102792	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0391303	0.00825025	0.000002126346	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0391252	0.00825025	0.000002132877	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0541992	0.0114298	0.000002136836	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0391211	0.00825025	0.000002138105	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05802244	chr1:2011082	1	2011082	PRKCZ	Open sea	0.152312	0.0321232	0.000002138504	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.0494174	0.0104233	0.000002146118	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0924714	0.0195179	0.000002181191	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0390732	0.00825027	0.000002200228	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0390722	0.00825027	0.000002201566	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0390379	0.00825028	0.000002247168	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0403021	0.00851837	0.000002252818	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0390261	0.00825028	0.000002263032	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08651178	chr1:2035295	1	2035295	PRKCZ	North shelf	0.216776	0.0458335	0.000002266812	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0675865	0.0142899	0.000002269657	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0390197	0.00825028	0.000002271747	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0493836	0.0104426	0.000002276553	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.254846	0.0539125	0.000002296246	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0389991	0.00825029	0.00000229982	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SYF2 protein levels (SeqId = 19438-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYF2 protein levels (SeqId = 19438-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pre-mRNA-splicing factor SYF2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000023	None	Gadd-DA_syf2_protein_levels__seqid___19438-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CETN2 protein levels (SeqId = 13078-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CETN2 protein levels (SeqId = 13078-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Centrin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000023	None	Gadd-DA_cetn2_protein_levels__seqid___13078-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0389792	0.0082503	0.00000232728	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.264286	0.0559616	0.000002346495	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0654964	0.0138735	0.000002368864	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0389425	0.00825031	0.000002378792	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HADH protein levels (SeqId = 17739-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HADH protein levels (SeqId = 17739-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000024	None	Gadd-DA_hadh_protein_levels__seqid___17739-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZP4 protein levels (SeqId = 7766-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZP4 protein levels (SeqId = 7766-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zona pellucida sperm-binding protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000024	None	Gadd-DA_zp4_protein_levels__seqid___7766-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANXA6 protein levels (SeqId = 5335-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANXA6 protein levels (SeqId = 5335-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Annexin A6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000024	None	Gadd-DA_anxa6_protein_levels__seqid___5335-73__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24447775	chr1:1992534	1	1992534	PRKCZ	South shore	-0.00096	0.0002	0.0000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.00038733	8.17e-05	0.00000241	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0388982	0.00825032	0.000002442328	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0686771	0.01457	0.000002456092	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0388771	0.00825033	0.00000247316	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0388694	0.00825033	0.000002484546	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RBBP6 protein levels (SeqId = 9887-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBBP6 protein levels (SeqId = 9887-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase RBBP6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000025	None	Gadd-DA_rbbp6_protein_levels__seqid___9887-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDC protein levels (SeqId = 8887-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDC protein levels (SeqId = 8887-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear migration protein nudC	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000025	None	Gadd-DA_nudc_protein_levels__seqid___8887-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF4B protein levels (SeqId = 14675-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF4B protein levels (SeqId = 14675-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 4B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000025	None	Gadd-DA_eif4b_protein_levels__seqid___14675-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAR protein levels (SeqId = 10085-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAR protein levels (SeqId = 10085-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Steroidogenic acute regulatory protein, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000025	None	Gadd-DA_star_protein_levels__seqid___10085-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZADH2 protein levels (SeqId = 17345-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZADH2 protein levels (SeqId = 17345-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prostaglandin reductase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.659	0.14	0.0000025	None	Gadd-DA_zadh2_protein_levels__seqid___17345-12__somascan_protein_measurement
Knijnenburg	None	30833390	Mar 19, 2019	very early preterm birth (<28 weeks)	EFO_0003917	discovery	Supplementary dataset 10	DNA methylation	very early preterm birth (<28 weeks)	Age, Ancestry (genomic PCs), time since birth	M values	None	Illumina HumanMethylation450	whole blood	None	784	1	Adults	Females	Admixed	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.55	0.115	0.0000025	None	30833390_Knijnenburg_very_early_preterm_birth___28_weeks__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.0421656	0.00895813	0.000002537373	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0388165	0.00825035	0.000002563974	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.149782	0.0318394	0.000002567161	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0387763	0.00825036	0.000002625809	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0506861	0.0107867	0.000002638712	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.040831	0.00869146	0.000002653366	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0387439	0.00825037	0.000002676822	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0387361	0.00825037	0.000002689292	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SLC14A1 protein levels (SeqId = 13430-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLC14A1 protein levels (SeqId = 13430-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Urea transporter 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000027	None	Gadd-DA_slc14a1_protein_levels__seqid___13430-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PGF protein levels (SeqId = 3078-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGF protein levels (SeqId = 3078-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Placenta growth factor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000027	None	Gadd-DA_pgf_protein_levels__seqid___3078-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NMI protein levels (SeqId = 17512-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMI protein levels (SeqId = 17512-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-myc-interactor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000027	None	Gadd-DA_nmi_protein_levels__seqid___17512-2__somascan_protein_measurement
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.00091334	0.00019364	0.00000272	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.147775	0.0315	0.000002734834	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0387066	0.00825038	0.000002736693	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0386791	0.00825039	0.000002781682	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TBL2 protein levels (SeqId = 11227-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBL2 protein levels (SeqId = 11227-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transducin beta-like protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000028	None	Gadd-DA_tbl2_protein_levels__seqid___11227-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDX3 protein levels (SeqId = 8358-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDX3 protein levels (SeqId = 8358-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin-dependent peroxide reductase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000028	None	Gadd-DA_prdx3_protein_levels__seqid___8358-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UFD1L protein levels (SeqId = 17411-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UFD1L protein levels (SeqId = 17411-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin recognition factor in ER-associated degradation protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000028	None	Gadd-DA_ufd1l_protein_levels__seqid___17411-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRKL protein levels (SeqId = 9877-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRKL protein levels (SeqId = 9877-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Crk-like protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000028	None	Gadd-DA_crkl_protein_levels__seqid___9877-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0386597	0.0082504	0.000002813842	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0386554	0.0082504	0.000002821012	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0386442	0.0082504	0.000002839646	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	0.0386185	0.00825041	0.000002883247	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0386142	0.00825041	0.000002890515	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Thyroxine (FT4)	CHEBI_30660, EFO_0005130	None	None	DNA methylation	Thyroxine (FT4)	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	pmol/l	Illumina HumanMethylation450	Whole blood	None	696	1	Adults	Females	European	cg11781622	chr1:2041072	1	2041072	PRKCZ	Island	0.074	0.0157	0.0000029	None	Battram-T_thyroxine__ft4_
Gadd DA	Generation Scotland	35945220	31/07/2022	GRB2 protein levels (SeqId = 5464-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRB2 protein levels (SeqId = 5464-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Growth factor receptor-bound protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000029	None	Gadd-DA_grb2_protein_levels__seqid___5464-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPOCK1 protein levels (SeqId = 5490-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPOCK1 protein levels (SeqId = 5490-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Testican-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.66	0.14	0.0000029	None	Gadd-DA_spock1_protein_levels__seqid___5490-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.0386076	0.00825042	0.000002901888	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0386007	0.00825042	0.000002913616	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0385966	0.00825042	0.000002920839	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0385931	0.00825042	0.000002926827	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0385886	0.00825042	0.000002934572	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0385788	0.00825042	0.00000295164	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0394911	0.00844723	0.000002965254	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0385551	0.00825043	0.000002993212	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0385538	0.00825043	0.000002995553	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.00046	0.000098	0.000003	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16269144	chr1:2003326	1	2003326	PRKCZ	North shore	0.0043	None	0.000003	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PPA2 protein levels (SeqId = 18307-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPA2 protein levels (SeqId = 18307-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inorganic pyrophosphatase 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.000003	None	Gadd-DA_ppa2_protein_levels__seqid___18307-71__somascan_protein_measurement
Battram T	GEO	30529013	2020-11-01	Melanoma	EFO_0000756	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE120878. Authors assessed methylation differences between melanoma samples and nevi	None	DNA methylation	Melanoma	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Skin	None	162	1	Adults	Both	Unclear	cg23803603	chr1:2058230	1	2058230	PRKCZ	Open sea	0.137	0.028	0.000003	None	30529013_Battram-T_melanoma_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse120878__authors_assessed_methylation_differences_between_melanoma_samples_and_nevi
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.006	None	0.000003	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0385294	0.00825044	0.00000303898	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06227939	chr1:2033594	1	2033594	PRKCZ	Open sea	0.0419061	0.00897699	0.000003065933	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.0396142	0.00848843	0.000003085674	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.038501	0.00825045	0.000003090409	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg13387826	chr1:2005260	1	2005260	PRKCZ	Island	0.021	0.004	0.0000031	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	NEK7 protein levels (SeqId = 12703-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEK7 protein levels (SeqId = 12703-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase Nek7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000031	None	Gadd-DA_nek7_protein_levels__seqid___12703-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.0385036	0.00825463	0.000003121173	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	0.0384778	0.00825046	0.000003132949	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0559951	0.012008	0.000003141838	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0384676	0.00825046	0.000003151762	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0384426	0.00825047	0.000003198456	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0384419	0.00825047	0.000003199834	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PDHX protein levels (SeqId = 18319-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDHX protein levels (SeqId = 18319-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyruvate dehydrogenase protein X component, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000032	None	Gadd-DA_pdhx_protein_levels__seqid___18319-7__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23629792	chr1:1987129	1	1987129	PRKCZ	North shelf	-0.00067	0.00014	0.0000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.038	0.00806	0.0000032	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0384263	0.00825047	0.000003229322	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05802244	chr1:2011082	1	2011082	PRKCZ	Open sea	0.149251	0.0320506	0.000003236603	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.182351	0.0391617	0.000003242397	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0486043	0.0104389	0.000003251232	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg25466090	chr1:2064691	1	2064691	PRKCZ	Island	1.059769	0.2277	0.00000326	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0406674	0.00873611	0.000003266697	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0383912	0.00825048	0.000003296668	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HSPE1 protein levels (SeqId = 17150-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSPE1 protein levels (SeqId = 17150-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 10 kDa heat shock protein, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000033	None	Gadd-DA_hspe1_protein_levels__seqid___17150-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NME2 protein levels (SeqId = 4249-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NME2 protein levels (SeqId = 4249-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nucleoside diphosphate kinase B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000033	None	Gadd-DA_nme2_protein_levels__seqid___4249-64__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0383851	0.00825049	0.000003308651	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.0383732	0.00825049	0.000003331893	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-	-	0.00000335	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.038362	0.00825049	0.000003353862	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0383454	0.0082505	0.000003386751	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAD1 protein levels (SeqId = 9838-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAD1 protein levels (SeqId = 9838-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mothers against decapentaplegic homolog 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000034	None	Gadd-DA_smad1_protein_levels__seqid___9838-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TKT protein levels (SeqId = 4306-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TKT protein levels (SeqId = 4306-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transketolase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000034	None	Gadd-DA_tkt_protein_levels__seqid___4306-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ENTPD6 protein levels (SeqId = 8932-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENTPD6 protein levels (SeqId = 8932-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000034	None	Gadd-DA_entpd6_protein_levels__seqid___8932-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0382948	0.00825052	0.000003488739	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP10 protein levels (SeqId = 8479-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP10 protein levels (SeqId = 8479-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromelysin-2	774	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-1.01	0.218	0.0000035	None	Gadd-DA_mmp10_protein_levels__seqid___8479-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AP2A2 protein levels (SeqId = 13621-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AP2A2 protein levels (SeqId = 13621-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: AP-2 complex subunit alpha-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000035	None	Gadd-DA_ap2a2_protein_levels__seqid___13621-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0382875	0.00825052	0.000003503661	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0382735	0.00825052	0.000003532697	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0382422	0.00825053	0.000003598062	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KLKB1 protein levels (SeqId = 4152-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLKB1 protein levels (SeqId = 4152-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plasma kallikrein	774	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-1.22	0.262	0.0000036	None	Gadd-DA_klkb1_protein_levels__seqid___4152-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SRC protein levels (SeqId = 15433-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SRC protein levels (SeqId = 15433-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proto-oncogene tyrosine-protein kinase Src	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000036	None	Gadd-DA_src_protein_levels__seqid___15433-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDKN1A protein levels (SeqId = 18291-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDKN1A protein levels (SeqId = 18291-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase inhibitor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000036	None	Gadd-DA_cdkn1a_protein_levels__seqid___18291-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB5A protein levels (SeqId = 17205-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB5A protein levels (SeqId = 17205-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-5A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000036	None	Gadd-DA_rab5a_protein_levels__seqid___17205-21__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0093	0.002	0.0000036	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0382384	0.00825053	0.000003606004	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0404309	0.00872369	0.000003606852	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.00046094	9.9e-05	0.00000363	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-0.0382267	0.00825054	0.000003630843	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0382242	0.00825054	0.000003636194	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0382163	0.00825054	0.000003653097	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	-0.0381967	0.00825055	0.000003695132	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12297010	chr1:2096582	1	2096582	PRKCZ	Open sea	0.0011	None	0.0000037	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAD3 protein levels (SeqId = 10363-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAD3 protein levels (SeqId = 10363-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mothers against decapentaplegic homolog 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000037	None	Gadd-DA_smad3_protein_levels__seqid___10363-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	-0.0381845	0.00825055	0.000003721746	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0381781	0.00825055	0.00000373563	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0381601	0.00825056	0.000003775293	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PANK3 protein levels (SeqId = 12658-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PANK3 protein levels (SeqId = 12658-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pantothenate kinase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000038	None	Gadd-DA_pank3_protein_levels__seqid___12658-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VAV3 protein levels (SeqId = 9830-109)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAV3 protein levels (SeqId = 9830-109)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanine nucleotide exchange factor VAV3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000038	None	Gadd-DA_vav3_protein_levels__seqid___9830-109__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PIR protein levels (SeqId = 13634-209)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PIR protein levels (SeqId = 13634-209)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pirin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000038	None	Gadd-DA_pir_protein_levels__seqid___13634-209__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA1279 protein levels (SeqId = 12956-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA1279 protein levels (SeqId = 12956-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: KIF1-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000038	None	Gadd-DA_kiaa1279_protein_levels__seqid___12956-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0381396	0.00825056	0.000003820621	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0381378	0.00825056	0.0000038248	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0557712	0.0120704	0.000003861047	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0381151	0.00825057	0.000003875723	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0381106	0.00825057	0.000003885933	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SPINK8 protein levels (SeqId = 7962-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPINK8 protein levels (SeqId = 7962-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine protease inhibitor Kazal-type 8	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_spink8_protein_levels__seqid___7962-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ENAH protein levels (SeqId = 9757-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENAH protein levels (SeqId = 9757-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein enabled homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_enah_protein_levels__seqid___9757-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COTL1 protein levels (SeqId = 4905-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COTL1 protein levels (SeqId = 4905-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coactosin-like protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_cotl1_protein_levels__seqid___4905-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNMD protein levels (SeqId = 6578-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNMD protein levels (SeqId = 6578-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tenomodulin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_tnmd_protein_levels__seqid___6578-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SYK protein levels (SeqId = 11378-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYK protein levels (SeqId = 11378-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein kinase SYK	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_syk_protein_levels__seqid___11378-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC4G protein levels (SeqId = 10781-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC4G protein levels (SeqId = 10781-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 4 member G	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000039	None	Gadd-DA_clec4g_protein_levels__seqid___10781-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0399791	0.00865674	0.000003902642	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0555668	0.0120393	0.000003956075	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.0380785	0.00825058	0.000003959616	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TRDMT1 protein levels (SeqId = 12635-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRDMT1 protein levels (SeqId = 12635-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: tRNA (cytosine(38)-C(5))-methyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.000004	None	Gadd-DA_trdmt1_protein_levels__seqid___12635-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HTR2A protein levels (SeqId = 13556-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HTR2A protein levels (SeqId = 13556-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 5-hydroxytryptamine receptor 2A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.000004	None	Gadd-DA_htr2a_protein_levels__seqid___13556-28__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	-0.025	0.00533	0.000004	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.0380554	0.00825059	0.000004013306	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.16627	0.0360652	0.000004050383	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	0.0380275	0.0082506	0.000004079136	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UBXN4 protein levels (SeqId = 9997-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBXN4 protein levels (SeqId = 9997-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UBX domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000041	None	Gadd-DA_ubxn4_protein_levels__seqid___9997-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TWF1 protein levels (SeqId = 12871-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TWF1 protein levels (SeqId = 12871-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Twinfilin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000041	None	Gadd-DA_twf1_protein_levels__seqid___12871-10__somascan_protein_measurement
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	-0.00030973	6.69e-05	0.00000411	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.0379881	0.00825061	0.000004173852	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0379824	0.00825061	0.000004187527	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0671911	0.0145969	0.000004197432	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0422951	0.00918842	0.000004197753	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07093776	chr1:2099468	1	2099468	PRKCZ	Open sea	0.006	None	0.0000042	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14778173	chr1:2103645	1	2103645	PRKCZ	Open sea	-0.00085	0.00018	0.0000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	HSP90AB1 protein levels (SeqId = 5467-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSP90AB1 protein levels (SeqId = 5467-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heat shock protein HSP 90-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000042	None	Gadd-DA_hsp90ab1_protein_levels__seqid___5467-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAP1GDS1 protein levels (SeqId = 14106-46)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAP1GDS1 protein levels (SeqId = 14106-46)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rap1 GTPase-GDP dissociation stimulator 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.65	0.14	0.0000042	None	Gadd-DA_rap1gds1_protein_levels__seqid___14106-46__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0379757	0.00825062	0.0000042039	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0420976	0.00914629	0.000004205526	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0379706	0.00825062	0.000004216619	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07375700	chr1:2013507	1	2013507	PRKCZ	Open sea	-0.180184	0.0391634	0.00000423647	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0379389	0.00825063	0.000004294917	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.049	0.01068	0.0000043	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.0379348	0.00825063	0.00000430521	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.230112	0.0500565	0.000004315376	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0379242	0.00825063	0.000004331998	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0405543	0.00882464	0.000004351423	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.251136	0.0546591	0.000004366729	None	39706196_Hannah-M.-Smith_bmi_discovery
Cardenas A	Project Viva	31300640	Jul 12, 2019	current asthma	MONDO_0004979	None	Table 3, Supplementary Data 1	DNA methylation	current asthma	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	None	Illumina HumanMethylationEPIC	nasal epithelium	None	463	1	Children	Both	Other	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-2.33	0.502	0.0000044	None	31300640_Cardenas-A_current_asthma
Gadd DA	Generation Scotland	35945220	31/07/2022	AP1G2 protein levels (SeqId = 12714-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AP1G2 protein levels (SeqId = 12714-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: AP-1 complex subunit gamma-like 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000044	None	Gadd-DA_ap1g2_protein_levels__seqid___12714-38__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANAPC10 protein levels (SeqId = 12345-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANAPC10 protein levels (SeqId = 12345-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anaphase-promoting complex subunit 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.643	0.14	0.0000044	None	Gadd-DA_anapc10_protein_levels__seqid___12345-4__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	-0.0048	0.001	0.0000044	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-0.012	0.0025	0.0000044	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.037896	0.00825064	0.000004403568	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	0.0378691	0.00825065	0.000004472705	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	0.0378651	0.00825065	0.000004483221	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	0.0378601	0.00825065	0.00000449637	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SULT1A3 protein levels (SeqId = 13944-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SULT1A3 protein levels (SeqId = 13944-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sulfotransferase 1A3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000045	None	Gadd-DA_sult1a3_protein_levels__seqid___13944-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VPS26A protein levels (SeqId = 19293-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VPS26A protein levels (SeqId = 19293-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vacuolar protein sorting-associated protein 26A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000045	None	Gadd-DA_vps26a_protein_levels__seqid___19293-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HSP90B1 protein levels (SeqId = 6393-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSP90B1 protein levels (SeqId = 6393-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endoplasmin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000045	None	Gadd-DA_hsp90b1_protein_levels__seqid___6393-63__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	0.146013	0.0318499	0.000004584848	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0545924	0.0119089	0.000004595417	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ZFYVE27 protein levels (SeqId = 9102-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZFYVE27 protein levels (SeqId = 9102-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protrudin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000046	None	Gadd-DA_zfyve27_protein_levels__seqid___9102-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KDELC2 protein levels (SeqId = 8296-117)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KDELC2 protein levels (SeqId = 8296-117)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein O-glucosyltransferase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000046	None	Gadd-DA_kdelc2_protein_levels__seqid___8296-117__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB5C protein levels (SeqId = 14287-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB5C protein levels (SeqId = 14287-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-5C	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000046	None	Gadd-DA_rab5c_protein_levels__seqid___14287-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0377851	0.00825068	0.000004696048	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK10 protein levels (SeqId = 15418-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK10 protein levels (SeqId = 15418-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000047	None	Gadd-DA_mapk10_protein_levels__seqid___15418-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SDF2 protein levels (SeqId = 15333-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDF2 protein levels (SeqId = 15333-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000047	None	Gadd-DA_sdf2_protein_levels__seqid___15333-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HSP90AA1 protein levels (SeqId = 2625-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSP90AA1 protein levels (SeqId = 2625-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heat shock protein HSP 90-alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000047	None	Gadd-DA_hsp90aa1_protein_levels__seqid___2625-53__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	-0.0068	0.0015	0.0000047	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0377788	0.00825068	0.000004713368	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0377596	0.00825068	0.000004766039	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0078	0.0017	0.0000048	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NR1H2 protein levels (SeqId = 9016-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NR1H2 protein levels (SeqId = 9016-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oxysterols receptor LXR-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000048	None	Gadd-DA_nr1h2_protein_levels__seqid___9016-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARHGAP1 protein levels (SeqId = 9815-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARHGAP1 protein levels (SeqId = 9815-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho GTPase-activating protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000048	None	Gadd-DA_arhgap1_protein_levels__seqid___9815-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKT2 protein levels (SeqId = 5360-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKT2 protein levels (SeqId = 5360-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RAC-beta serine/threonine-protein kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000048	None	Gadd-DA_akt2_protein_levels__seqid___5360-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EFNB1 protein levels (SeqId = 13104-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFNB1 protein levels (SeqId = 13104-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin-B1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000048	None	Gadd-DA_efnb1_protein_levels__seqid___13104-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0377401	0.00825069	0.000004820128	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.0415047	0.00907457	0.000004830181	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0377223	0.00825069	0.000004870075	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.0377215	0.0082507	0.000004872212	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.0377084	0.0082507	0.00000490943	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.0414597	0.00907342	0.000004932174	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0376769	0.00825071	0.000004999712	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BOLA3 protein levels (SeqId = 5980-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BOLA3 protein levels (SeqId = 5980-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BolA-like protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.000005	None	Gadd-DA_bola3_protein_levels__seqid___5980-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PKM2 protein levels (SeqId = 4240-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PKM2 protein levels (SeqId = 4240-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyruvate kinase PKM	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.000005	None	Gadd-DA_pkm2_protein_levels__seqid___4240-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UGT2A1 protein levels (SeqId = 8907-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UGT2A1 protein levels (SeqId = 8907-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UDP-glucuronosyltransferase 2A1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.000005	None	Gadd-DA_ugt2a1_protein_levels__seqid___8907-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ELK1 protein levels (SeqId = 10006-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ELK1 protein levels (SeqId = 10006-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ETS domain-containing protein Elk-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.000005	None	Gadd-DA_elk1_protein_levels__seqid___10006-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HSD17B10 protein levels (SeqId = 4217-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSD17B10 protein levels (SeqId = 4217-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3-hydroxyacyl-CoA dehydrogenase type-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.000005	None	Gadd-DA_hsd17b10_protein_levels__seqid___4217-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0376707	0.00825071	0.000005017476	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	0.0376584	0.00825071	0.000005053184	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0548338	0.0120187	0.000005099136	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ESAM protein levels (SeqId = 7841-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ESAM protein levels (SeqId = 7841-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endothelial cell-selective adhesion molecule	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000051	None	Gadd-DA_esam_protein_levels__seqid___7841-84__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KPNB1 protein levels (SeqId = 3887-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KPNB1 protein levels (SeqId = 3887-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Importin subunit beta-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000051	None	Gadd-DA_kpnb1_protein_levels__seqid___3887-90__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PFDN5 protein levels (SeqId = 4271-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PFDN5 protein levels (SeqId = 4271-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prefoldin subunit 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000051	None	Gadd-DA_pfdn5_protein_levels__seqid___4271-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DLX4 protein levels (SeqId = 11910-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DLX4 protein levels (SeqId = 11910-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Homeobox protein DLX-4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000051	None	Gadd-DA_dlx4_protein_levels__seqid___11910-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.037637	0.00825072	0.000005116246	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0376305	0.00825072	0.000005135342	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.969234	0.2127	0.00000518	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0616694	0.0135289	0.000005197916	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ADRBK1 protein levels (SeqId = 3347-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADRBK1 protein levels (SeqId = 3347-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-adrenergic receptor kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000052	None	Gadd-DA_adrbk1_protein_levels__seqid___3347-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NPLOC4 protein levels (SeqId = 12993-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPLOC4 protein levels (SeqId = 12993-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear protein localization protein 4 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000052	None	Gadd-DA_nploc4_protein_levels__seqid___12993-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2K protein levels (SeqId = 17380-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2K protein levels (SeqId = 17380-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 K	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000052	None	Gadd-DA_ube2k_protein_levels__seqid___17380-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0376033	0.00825073	0.000005216624	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.0375971	0.00825073	0.000005235278	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.195066	0.0428125	0.000005241937	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01974180	chr1:2084246	1	2084246	PRKCZ	South shore	0.0375782	0.0082486	0.000005263061	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0375772	0.00825074	0.000005295631	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.00417	0.00092	0.0000053	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0015	None	0.0000053	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	RNF8 protein levels (SeqId = 14663-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNF8 protein levels (SeqId = 14663-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase RNF8	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000053	None	Gadd-DA_rnf8_protein_levels__seqid___14663-44__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCDC134 protein levels (SeqId = 15300-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCDC134 protein levels (SeqId = 15300-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coiled-coil domain-containing protein 134	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000053	None	Gadd-DA_ccdc134_protein_levels__seqid___15300-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SH3GL3 protein levels (SeqId = 18318-98)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SH3GL3 protein levels (SeqId = 18318-98)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endophilin-A3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000053	None	Gadd-DA_sh3gl3_protein_levels__seqid___18318-98__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACTN1 protein levels (SeqId = 9843-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACTN1 protein levels (SeqId = 9843-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-actinin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000053	None	Gadd-DA_actn1_protein_levels__seqid___9843-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0375621	0.00825074	0.000005342047	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg11781622	chr1:2041072	1	2041072	PRKCZ	Island	-0.1298082	0.0285276	0.000005358	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0375525	0.00825075	0.000005371714	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0376856	0.00828087	0.000005384022	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ANXA7 protein levels (SeqId = 14203-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANXA7 protein levels (SeqId = 14203-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Annexin A7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000054	None	Gadd-DA_anxa7_protein_levels__seqid___14203-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACBD6 protein levels (SeqId = 10075-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACBD6 protein levels (SeqId = 10075-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acyl-CoA-binding domain-containing protein 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000054	None	Gadd-DA_acbd6_protein_levels__seqid___10075-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GSTK1 protein levels (SeqId = 13474-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSTK1 protein levels (SeqId = 13474-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione S-transferase kappa 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000054	None	Gadd-DA_gstk1_protein_levels__seqid___13474-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	B3GALTL protein levels (SeqId = 5727-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B3GALTL protein levels (SeqId = 5727-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,3-glucosyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000054	None	Gadd-DA_b3galtl_protein_levels__seqid___5727-35__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	-0.192743	0.0423616	0.000005400427	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.00041432	9.07e-05	0.00000544	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.03753	0.00825075	0.000005441598	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-	-	0.00000546	-	26500701_sex_kora_f4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.00070818	0.00015498	0.00000546	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	BCAT2 protein levels (SeqId = 19365-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BCAT2 protein levels (SeqId = 19365-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Branched-chain-amino-acid aminotransferase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000055	None	Gadd-DA_bcat2_protein_levels__seqid___19365-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BRD2 protein levels (SeqId = 15372-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BRD2 protein levels (SeqId = 15372-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bromodomain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000055	None	Gadd-DA_brd2_protein_levels__seqid___15372-43__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UFC1 protein levels (SeqId = 3405-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UFC1 protein levels (SeqId = 3405-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-fold modifier-conjugating enzyme 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000055	None	Gadd-DA_ufc1_protein_levels__seqid___3405-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	-0.0375067	0.00825076	0.000005515269	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0374958	0.00825077	0.000005550001	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14163740	chr1:2006139	1	2006139	PRKCZ	South shore	-0.0374886	0.00825077	0.000005572953	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	AHCYL1 protein levels (SeqId = 12652-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AHCYL1 protein levels (SeqId = 12652-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: S-adenosylhomocysteine hydrolase-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000056	None	Gadd-DA_ahcyl1_protein_levels__seqid___12652-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0893578	0.0196752	0.000005626117	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01907016	chr1:1985500	1	1985500	PRKCZ	South shelf	0.00789	0.00169	0.0000057	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	FLT3LG protein levels (SeqId = 14093-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLT3LG protein levels (SeqId = 14093-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fms-related tyrosine kinase 3 ligand	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000057	None	Gadd-DA_flt3lg_protein_levels__seqid___14093-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	G6PD protein levels (SeqId = 19297-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	G6PD protein levels (SeqId = 19297-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glucose-6-phosphate 1-dehydrogenase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000057	None	Gadd-DA_g6pd_protein_levels__seqid___19297-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRP1B protein levels (SeqId = 11275-94)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRP1B protein levels (SeqId = 11275-94)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low-density lipoprotein receptor-related protein 1B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000057	None	Gadd-DA_lrp1b_protein_levels__seqid___11275-94__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0463554	0.0102132	0.000005703284	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0374406	0.00825078	0.000005729039	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0933358	0.0205783	0.000005743	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.204042	0.0449749	0.000005750236	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Shah S	-	25249537	2014-09-23	Sex	PATO_0000047	Discovery	Table S3	DNA methylation	Sex	Smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	815	1	70	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-	-	0.00000577	-	25249537_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-0.138229	0.0304779	0.00000578642	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	HTRA2 protein levels (SeqId = 3317-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HTRA2 protein levels (SeqId = 3317-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine protease HTRA2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000058	None	Gadd-DA_htra2_protein_levels__seqid___3317-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPT1 protein levels (SeqId = 9244-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPT1 protein levels (SeqId = 9244-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Palmitoyl-protein thioesterase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000058	None	Gadd-DA_ppt1_protein_levels__seqid___9244-27__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25407448	chr1:2043037	1	2043037	PRKCZ	South shore	-0.0007	0.00015	0.0000058	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0374068	0.00825079	0.00000584106	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0541952	0.0119542	0.00000584548	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0375032	0.00827423	0.000005874116	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PRNP protein levels (SeqId = 6545-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRNP protein levels (SeqId = 6545-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Major prion protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000059	None	Gadd-DA_prnp_protein_levels__seqid___6545-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCPG1 protein levels (SeqId = 8889-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCPG1 protein levels (SeqId = 8889-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cell cycle progression protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000059	None	Gadd-DA_ccpg1_protein_levels__seqid___8889-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAD23A protein levels (SeqId = 10058-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAD23A protein levels (SeqId = 10058-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UV excision repair protein RAD23 homolog A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.64	0.14	0.0000059	None	Gadd-DA_rad23a_protein_levels__seqid___10058-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINA1 protein levels (SeqId = 3580-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINA1 protein levels (SeqId = 3580-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-1-antitrypsin	774	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.727	0.161	0.0000059	None	Gadd-DA_serpina1_protein_levels__seqid___3580-25__somascan_protein_measurement
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.5329098	0.1176	0.00000591	-	27602958_smoking_packyears_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	DCAF5 protein levels (SeqId = 11283-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DCAF5 protein levels (SeqId = 11283-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DDB1- and CUL4-associated factor 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000006	None	Gadd-DA_dcaf5_protein_levels__seqid___11283-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TSSC4 protein levels (SeqId = 18181-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TSSC4 protein levels (SeqId = 18181-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein TSSC4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000006	None	Gadd-DA_tssc4_protein_levels__seqid___18181-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPHK2 protein levels (SeqId = 4468-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPHK2 protein levels (SeqId = 4468-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sphingosine kinase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000006	None	Gadd-DA_sphk2_protein_levels__seqid___4468-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DPP7 protein levels (SeqId = 8346-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DPP7 protein levels (SeqId = 8346-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dipeptidyl peptidase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.633	0.14	0.000006	None	Gadd-DA_dpp7_protein_levels__seqid___8346-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BPNT1 protein levels (SeqId = 17814-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BPNT1 protein levels (SeqId = 17814-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3'(2'),5'-bisphosphate nucleotidase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000006	None	Gadd-DA_bpnt1_protein_levels__seqid___17814-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX6 protein levels (SeqId = 12869-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX6 protein levels (SeqId = 12869-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable ATP-dependent RNA helicase DDX6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000006	None	Gadd-DA_ddx6_protein_levels__seqid___12869-68__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.017	0.00366	0.000006	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	-0.96578	0.2134	0.00000602	-	27105112_hiv_infection_discovery
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-11.9	2.6	0.0000061	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB6B protein levels (SeqId = 14271-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB6B protein levels (SeqId = 14271-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-6B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000061	None	Gadd-DA_rab6b_protein_levels__seqid___14271-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB5B protein levels (SeqId = 19222-124)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB5B protein levels (SeqId = 19222-124)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-5B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000061	None	Gadd-DA_rab5b_protein_levels__seqid___19222-124__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCL26 protein levels (SeqId = 9168-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCL26 protein levels (SeqId = 9168-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-C motif chemokine 26	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000061	None	Gadd-DA_ccl26_protein_levels__seqid___9168-31__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.066	0.01465	0.0000061	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0380164	0.00840622	0.00000616174	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	G6B protein levels (SeqId = 8659-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	G6B protein levels (SeqId = 8659-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Megakaryocyte and platelet inhibitory receptor G6b	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000062	None	Gadd-DA_g6b_protein_levels__seqid___8659-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ABHD10 protein levels (SeqId = 17370-186)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ABHD10 protein levels (SeqId = 17370-186)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mycophenolic acid acyl-glucuronide esterase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000062	None	Gadd-DA_abhd10_protein_levels__seqid___17370-186__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0372953	0.00825083	0.000006226636	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	-0.139734	0.0309246	0.000006265605	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	GNPNAT1 protein levels (SeqId = 13954-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNPNAT1 protein levels (SeqId = 13954-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glucosamine 6-phosphate N-acetyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000063	None	Gadd-DA_gnpnat1_protein_levels__seqid___13954-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LANCL1 protein levels (SeqId = 13986-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LANCL1 protein levels (SeqId = 13986-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione S-transferase LANCL1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000063	None	Gadd-DA_lancl1_protein_levels__seqid___13986-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SHMT2 protein levels (SeqId = 12691-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHMT2 protein levels (SeqId = 12691-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine hydroxymethyltransferase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000063	None	Gadd-DA_shmt2_protein_levels__seqid___12691-44__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	0.0372705	0.00825083	0.000006315789	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0372396	0.00825084	0.000006428251	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0372276	0.00825085	0.000006472744	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15703790	chr1:1993510	1	1993510	PRKCZ	South shelf	0.01107	0.00239	0.0000065	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKG1 protein levels (SeqId = 13067-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKG1 protein levels (SeqId = 13067-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: cGMP-dependent protein kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000065	None	Gadd-DA_prkg1_protein_levels__seqid___13067-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APOBEC3G protein levels (SeqId = 13930-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOBEC3G protein levels (SeqId = 13930-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA dC->dU-editing enzyme APOBEC-3G	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000065	None	Gadd-DA_apobec3g_protein_levels__seqid___13930-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EFNB2 protein levels (SeqId = 8772-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFNB2 protein levels (SeqId = 8772-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin-B2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.633	0.14	0.0000065	None	Gadd-DA_efnb2_protein_levels__seqid___8772-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	QPRT protein levels (SeqId = 17789-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	QPRT protein levels (SeqId = 17789-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000065	None	Gadd-DA_qprt_protein_levels__seqid___17789-1__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.239243	0.0531	0.00000654	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0372084	0.00825085	0.000006544224	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02361803	chr1:2014371	1	2014371	PRKCZ	Open sea	0.01419	0.00306	0.0000066	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	NCK2 protein levels (SeqId = 13615-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCK2 protein levels (SeqId = 13615-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytoplasmic protein NCK2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000066	None	Gadd-DA_nck2_protein_levels__seqid___13615-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0702398	0.0155834	0.000006615043	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0371763	0.00825086	0.000006665134	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0371723	0.00825087	0.0000066804	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TAX1BP1 protein levels (SeqId = 12721-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAX1BP1 protein levels (SeqId = 12721-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tax1-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000067	None	Gadd-DA_tax1bp1_protein_levels__seqid___12721-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARL1 protein levels (SeqId = 12392-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARL1 protein levels (SeqId = 12392-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000067	None	Gadd-DA_arl1_protein_levels__seqid___12392-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RHOA protein levels (SeqId = 9855-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RHOA protein levels (SeqId = 9855-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transforming protein RhoA	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000067	None	Gadd-DA_rhoa_protein_levels__seqid___9855-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDC42 protein levels (SeqId = 9840-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDC42 protein levels (SeqId = 9840-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cell division control protein 42 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000067	None	Gadd-DA_cdc42_protein_levels__seqid___9840-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0881934	0.0195914	0.000006795194	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	F11 protein levels (SeqId = 2190-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	F11 protein levels (SeqId = 2190-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coagulation factor XI	774	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-1.18	0.262	0.0000068	None	Gadd-DA_f11_protein_levels__seqid___2190-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPRE1 protein levels (SeqId = 12469-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPRE1 protein levels (SeqId = 12469-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Microtubule-associated protein RP/EB family member 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000068	None	Gadd-DA_mapre1_protein_levels__seqid___12469-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NSF protein levels (SeqId = 13992-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NSF protein levels (SeqId = 13992-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vesicle-fusing ATPase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000068	None	Gadd-DA_nsf_protein_levels__seqid___13992-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPBP protein levels (SeqId = 16765-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPBP protein levels (SeqId = 16765-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet basic protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000068	None	Gadd-DA_ppbp_protein_levels__seqid___16765-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDIA3 protein levels (SeqId = 4719-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDIA3 protein levels (SeqId = 4719-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase A3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000068	None	Gadd-DA_pdia3_protein_levels__seqid___4719-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB1B protein levels (SeqId = 19278-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB1B protein levels (SeqId = 19278-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-1B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000068	None	Gadd-DA_rab1b_protein_levels__seqid___19278-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0914907	0.0203282	0.000006825843	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0371306	0.00825088	0.000006841029	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02854763	chr1:2103155	1	2103155	PRKCZ	Open sea	0.00058	None	0.000007	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	C10orf54 protein levels (SeqId = 11531-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C10orf54 protein levels (SeqId = 11531-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: V-type immunoglobulin domain-containing suppressor of T-cell activation	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000007	None	Gadd-DA_c10orf54_protein_levels__seqid___11531-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARHGDIB protein levels (SeqId = 9846-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARHGDIB protein levels (SeqId = 9846-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho GDP-dissociation inhibitor 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000007	None	Gadd-DA_arhgdib_protein_levels__seqid___9846-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0370811	0.00825089	0.000007036721	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0370778	0.00825089	0.000007050271	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0370695	0.0082509	0.000007083541	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PCTK1 protein levels (SeqId = 16867-76)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCTK1 protein levels (SeqId = 16867-76)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase 16	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000071	None	Gadd-DA_pctk1_protein_levels__seqid___16867-76__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23048698	chr1:2109816	1	2109816	PRKCZ	Open sea	-0.0007	0.00016	0.0000071	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0370645	0.0082509	0.000007103598	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11227141	chr1:2003650	1	2003650	PRKCZ	North shore	-0.175159	0.0389994	0.000007123813	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0458092	0.0102012	0.000007158148	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0390412	0.00869506	0.00000717533	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0370437	0.0082509	0.000007188238	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RAD23B protein levels (SeqId = 12522-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAD23B protein levels (SeqId = 12522-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UV excision repair protein RAD23 homolog B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000072	None	Gadd-DA_rad23b_protein_levels__seqid___12522-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0439103	0.00978254	0.000007222457	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.054159	0.0120658	0.000007222865	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0370227	0.00825091	0.00000727463	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	0.0370208	0.00825091	0.000007282682	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16059943	chr1:2013748	1	2013748	PRKCZ	Open sea	0.0012	None	0.0000073	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB11A protein levels (SeqId = 17744-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB11A protein levels (SeqId = 17744-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-11A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000073	None	Gadd-DA_rab11a_protein_levels__seqid___17744-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0370161	0.00825091	0.0000073019	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0370067	0.00825092	0.000007341055	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	-0.0377147	0.00840983	0.000007360696	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TTC1 protein levels (SeqId = 9864-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TTC1 protein levels (SeqId = 9864-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tetratricopeptide repeat protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000074	None	Gadd-DA_ttc1_protein_levels__seqid___9864-38__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0764643	0.0170565	0.000007415759	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.156578	0.0349333	0.000007435812	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.0369806	0.00825092	0.000007450805	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0369694	0.00825093	0.000007498595	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HDHD3 protein levels (SeqId = 19482-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDHD3 protein levels (SeqId = 19482-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Haloacid dehalogenase-like hydrolase domain-containing protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000075	None	Gadd-DA_hdhd3_protein_levels__seqid___19482-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS7 protein levels (SeqId = 9196-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS7 protein levels (SeqId = 9196-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.628	0.14	0.0000075	None	Gadd-DA_lgals7_protein_levels__seqid___9196-8__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23648809	chr1:2106400	1	2106400	PRKCZ	Open sea	0.02932	0.00637	0.0000075	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0369614	0.00825093	0.000007532465	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.236335	0.0527685	0.00000755483	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.217517	0.0485687	0.000007563635	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.00089	0.0002	0.0000076	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PGM2 protein levels (SeqId = 18330-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGM2 protein levels (SeqId = 18330-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglucomutase-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000076	None	Gadd-DA_pgm2_protein_levels__seqid___18330-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PTK2B protein levels (SeqId = 8918-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTK2B protein levels (SeqId = 8918-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein-tyrosine kinase 2-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000076	None	Gadd-DA_ptk2b_protein_levels__seqid___8918-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SAMHD1 protein levels (SeqId = 11303-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SAMHD1 protein levels (SeqId = 11303-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.628	0.14	0.0000076	None	Gadd-DA_samhd1_protein_levels__seqid___11303-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LCMT1 protein levels (SeqId = 4237-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LCMT1 protein levels (SeqId = 4237-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine carboxyl methyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000076	None	Gadd-DA_lcmt1_protein_levels__seqid___4237-70__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	0.169614	0.0378954	0.000007659105	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Battram T	GEO	23792949	2020-09-15	Ethnicity	EFO_0001799	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE39672. Compared European and African samples from HapMap (CEU and YRI)	None	DNA methylation	Ethnicity	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Lymphoblasts	None	133	1	Adults	Both	European, African	cg10761639	chr1:2023794	1	2023794	PRKCZ	North shore	-0.269	0.0573	0.0000077	None	23792949_Battram-T_ethnicity_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse39672__compared_european_and_african_samples_from_hapmap__ceu_and_yri_
Gadd DA	Generation Scotland	35945220	31/07/2022	ACADVL protein levels (SeqId = 19262-219)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACADVL protein levels (SeqId = 19262-219)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000077	None	Gadd-DA_acadvl_protein_levels__seqid___19262-219__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0369075	0.00825095	0.000007766322	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RHOG protein levels (SeqId = 12540-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RHOG protein levels (SeqId = 12540-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho-related GTP-binding protein RhoG	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000078	None	Gadd-DA_rhog_protein_levels__seqid___12540-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TBCE protein levels (SeqId = 11211-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBCE protein levels (SeqId = 11211-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tubulin-specific chaperone E	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000078	None	Gadd-DA_tbce_protein_levels__seqid___11211-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.0368982	0.00825095	0.000007807476	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0406925	0.00909985	0.000007815568	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	-0.00019903	4.43e-05	0.00000787	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0062	0.0014	0.0000079	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC1B protein levels (SeqId = 4332-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC1B protein levels (SeqId = 4332-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 1 member B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000079	None	Gadd-DA_clec1b_protein_levels__seqid___4332-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GGA3 protein levels (SeqId = 11683-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GGA3 protein levels (SeqId = 11683-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-binding protein GGA3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000079	None	Gadd-DA_gga3_protein_levels__seqid___11683-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	0.0573155	0.0128269	0.000007940795	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.0368652	0.00825096	0.000007954871	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SYN3 protein levels (SeqId = 7199-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYN3 protein levels (SeqId = 7199-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synapsin-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000008	None	Gadd-DA_syn3_protein_levels__seqid___7199-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MRRF protein levels (SeqId = 12355-223)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRRF protein levels (SeqId = 12355-223)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosome-recycling factor, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000008	None	Gadd-DA_mrrf_protein_levels__seqid___12355-223__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDT9 protein levels (SeqId = 9482-110)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDT9 protein levels (SeqId = 9482-110)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribose pyrophosphatase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000008	None	Gadd-DA_nudt9_protein_levels__seqid___9482-110__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADH6 protein levels (SeqId = 18206-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADH6 protein levels (SeqId = 18206-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alcohol dehydrogenase 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.000008	None	Gadd-DA_adh6_protein_levels__seqid___18206-18__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	0.00035	None	0.0000081	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.00073	0.00016	0.0000081	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	AKT1 protein levels (SeqId = 15627-83)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKT1 protein levels (SeqId = 15627-83)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RAC-alpha serine/threonine-protein kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000081	None	Gadd-DA_akt1_protein_levels__seqid___15627-83__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ERO1L protein levels (SeqId = 7060-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ERO1L protein levels (SeqId = 7060-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ERO1-like protein alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000081	None	Gadd-DA_ero1l_protein_levels__seqid___7060-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11335286	chr1:2086528	1	2086528	PRKCZ	South shelf	0.0368284	0.00825097	0.000008122468	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0368191	0.00825097	0.000008165121	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0368178	0.00825097	0.000008171305	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MTRF1L protein levels (SeqId = 11134-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTRF1L protein levels (SeqId = 11134-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptide chain release factor 1-like, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.623	0.14	0.0000082	None	Gadd-DA_mtrf1l_protein_levels__seqid___11134-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSME1 protein levels (SeqId = 5918-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSME1 protein levels (SeqId = 5918-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome activator complex subunit 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000082	None	Gadd-DA_psme1_protein_levels__seqid___5918-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MYCBP protein levels (SeqId = 19250-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MYCBP protein levels (SeqId = 19250-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: c-Myc-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000082	None	Gadd-DA_mycbp_protein_levels__seqid___19250-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CISD2 protein levels (SeqId = 8094-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CISD2 protein levels (SeqId = 8094-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CDGSH iron-sulfur domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.624	0.14	0.0000082	None	Gadd-DA_cisd2_protein_levels__seqid___8094-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0480089	0.0107614	0.000008211013	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	-0.121733	0.0272965	0.000008257965	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0450017	0.0100917	0.000008284227	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CLIC4 protein levels (SeqId = 15314-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLIC4 protein levels (SeqId = 15314-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chloride intracellular channel protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000083	None	Gadd-DA_clic4_protein_levels__seqid___15314-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDIA5 protein levels (SeqId = 5593-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDIA5 protein levels (SeqId = 5593-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase A5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000083	None	Gadd-DA_pdia5_protein_levels__seqid___5593-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAT3 protein levels (SeqId = 10346-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAT3 protein levels (SeqId = 10346-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal transducer and activator of transcription 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000083	None	Gadd-DA_stat3_protein_levels__seqid___10346-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TPI1 protein levels (SeqId = 4309-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPI1 protein levels (SeqId = 4309-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Triosephosphate isomerase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.63	0.14	0.0000083	None	Gadd-DA_tpi1_protein_levels__seqid___4309-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAWR protein levels (SeqId = 9565-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAWR protein levels (SeqId = 9565-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PRKC apoptosis WT1 regulator protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000083	None	Gadd-DA_pawr_protein_levels__seqid___9565-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0865456	0.0194135	0.000008333627	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	0.814132	0.1827	0.00000837	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0367709	0.00825099	0.000008390575	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0439716	0.00986715	0.000008398083	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIH protein levels (SeqId = 12449-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIH protein levels (SeqId = 12449-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase H	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000084	None	Gadd-DA_ppih_protein_levels__seqid___12449-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ETNK1 protein levels (SeqId = 8328-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ETNK1 protein levels (SeqId = 8328-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ethanolamine kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.624	0.14	0.0000084	None	Gadd-DA_etnk1_protein_levels__seqid___8328-9__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20250605	chr1:2046506	1	2046506	PRKCZ	Island	0.0033	None	0.0000084	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	2,4-Dichlorophenoxyacetic acid (2,4-D)	CHEBI_28854	discovery	10.5281/zenodo.5156585	DNA methylation	2,4-Dichlorophenoxyacetic acid (2,4-D)	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	466	1	Adults	Males	European	cg15575834	chr1:2099845	1	2099845	PRKCZ	Open sea	0.00168	0.00038	0.0000085	None	34516295_Hoang_2_4-dichlorophenoxyacetic_acid__2_4-d__discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SIRT3 protein levels (SeqId = 17495-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIRT3 protein levels (SeqId = 17495-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000085	None	Gadd-DA_sirt3_protein_levels__seqid___17495-141__somascan_protein_measurement
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.013	0.003	0.00000855	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.002	0.00043	0.0000086	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPSS1 protein levels (SeqId = 14007-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPSS1 protein levels (SeqId = 14007-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000086	None	Gadd-DA_papss1_protein_levels__seqid___14007-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ISM1 protein levels (SeqId = 8355-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISM1 protein levels (SeqId = 8355-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Isthmin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000086	None	Gadd-DA_ism1_protein_levels__seqid___8355-80__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0367255	0.008251	0.000008608926	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0367209	0.008251	0.000008630962	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TRIP10 protein levels (SeqId = 17676-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRIP10 protein levels (SeqId = 17676-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cdc42-interacting protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000087	None	Gadd-DA_trip10_protein_levels__seqid___17676-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NDC80 protein levels (SeqId = 12730-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDC80 protein levels (SeqId = 12730-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kinetochore protein NDC80 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000087	None	Gadd-DA_ndc80_protein_levels__seqid___12730-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPARC protein levels (SeqId = 3043-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPARC protein levels (SeqId = 3043-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SPARC	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000087	None	Gadd-DA_sparc_protein_levels__seqid___3043-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB6 protein levels (SeqId = 11606-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB6 protein levels (SeqId = 11606-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000087	None	Gadd-DA_dnajb6_protein_levels__seqid___11606-22__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0366981	0.00825101	0.000008742925	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0458795	0.0103186	0.00000879996	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	MYL12B protein levels (SeqId = 19122-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MYL12B protein levels (SeqId = 19122-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myosin regulatory light chain 12B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000088	None	Gadd-DA_myl12b_protein_levels__seqid___19122-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EHD4 protein levels (SeqId = 11421-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EHD4 protein levels (SeqId = 11421-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: EH domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000088	None	Gadd-DA_ehd4_protein_levels__seqid___11421-10__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	0.107233	0.0241203	0.000008813146	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0366837	0.00825101	0.000008814051	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.036678	0.00825102	0.000008842397	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0366712	0.00825102	0.000008876285	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0378184	0.00851274	0.000008954346	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TIMM50 protein levels (SeqId = 7743-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIMM50 protein levels (SeqId = 7743-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitochondrial import inner membrane translocase subunit TIM50	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000009	None	Gadd-DA_timm50_protein_levels__seqid___7743-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAC1 protein levels (SeqId = 2870-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAC1 protein levels (SeqId = 2870-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related C3 botulinum toxin substrate 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000009	None	Gadd-DA_rac1_protein_levels__seqid___2870-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NR5A2 protein levels (SeqId = 12444-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NR5A2 protein levels (SeqId = 12444-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear receptor subfamily 5 group A member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000009	None	Gadd-DA_nr5a2_protein_levels__seqid___12444-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CS protein levels (SeqId = 18309-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CS protein levels (SeqId = 18309-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Citrate synthase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000009	None	Gadd-DA_cs_protein_levels__seqid___18309-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0366425	0.00825103	0.000009021292	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0366286	0.00825103	0.000009092126	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07570618	chr1:1992389	1	1992389	PRKCZ	South shore	0.0018	None	0.0000091	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PRPSAP2 protein levels (SeqId = 19150-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRPSAP2 protein levels (SeqId = 19150-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoribosyl pyrophosphate synthase-associated protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000091	None	Gadd-DA_prpsap2_protein_levels__seqid___19150-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UXS1 protein levels (SeqId = 8258-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UXS1 protein levels (SeqId = 8258-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UDP-glucuronic acid decarboxylase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000091	None	Gadd-DA_uxs1_protein_levels__seqid___8258-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GRPEL1 protein levels (SeqId = 7113-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRPEL1 protein levels (SeqId = 7113-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GrpE protein homolog 1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000091	None	Gadd-DA_grpel1_protein_levels__seqid___7113-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AASDHPPT protein levels (SeqId = 17320-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AASDHPPT protein levels (SeqId = 17320-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000091	None	Gadd-DA_aasdhppt_protein_levels__seqid___17320-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0366156	0.00825103	0.000009158764	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BDP1 protein levels (SeqId = 8929-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDP1 protein levels (SeqId = 8929-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription factor TFIIIB component B'' homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_bdp1_protein_levels__seqid___8929-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HEPHL1 protein levels (SeqId = 6354-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HEPHL1 protein levels (SeqId = 6354-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hephaestin-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_hephl1_protein_levels__seqid___6354-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DTYMK protein levels (SeqId = 19504-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DTYMK protein levels (SeqId = 19504-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thymidylate kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_dtymk_protein_levels__seqid___19504-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	G3BP1 protein levels (SeqId = 19266-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	G3BP1 protein levels (SeqId = 19266-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras GTPase-activating protein-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_g3bp1_protein_levels__seqid___19266-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CAB39 protein levels (SeqId = 17757-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAB39 protein levels (SeqId = 17757-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-binding protein 39	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_cab39_protein_levels__seqid___17757-86__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNX4 protein levels (SeqId = 3903-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNX4 protein levels (SeqId = 3903-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sorting nexin-4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000092	None	Gadd-DA_snx4_protein_levels__seqid___3903-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARMC5 protein levels (SeqId = 8785-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARMC5 protein levels (SeqId = 8785-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Armadillo repeat-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000093	None	Gadd-DA_armc5_protein_levels__seqid___8785-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0365756	0.00825105	0.000009367237	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RDX protein levels (SeqId = 18373-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RDX protein levels (SeqId = 18373-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Radixin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000094	None	Gadd-DA_rdx_protein_levels__seqid___18373-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAP2K3 protein levels (SeqId = 6151-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAP2K3 protein levels (SeqId = 6151-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000094	None	Gadd-DA_map2k3_protein_levels__seqid___6151-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RIC3 protein levels (SeqId = 11228-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RIC3 protein levels (SeqId = 11228-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein RIC-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000094	None	Gadd-DA_ric3_protein_levels__seqid___11228-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	0.0365578	0.00825105	0.000009461749	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TTL protein levels (SeqId = 13973-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TTL protein levels (SeqId = 13973-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tubulin--tyrosine ligase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000095	None	Gadd-DA_ttl_protein_levels__seqid___13973-62__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0365367	0.00825106	0.00000957462	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0365351	0.00825106	0.000009582865	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EDC4 protein levels (SeqId = 13066-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EDC4 protein levels (SeqId = 13066-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Enhancer of mRNA-decapping protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000096	None	Gadd-DA_edc4_protein_levels__seqid___13066-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC5 protein levels (SeqId = 11212-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC5 protein levels (SeqId = 11212-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.621	0.14	0.0000096	None	Gadd-DA_txndc5_protein_levels__seqid___11212-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0365215	0.00825106	0.000009656314	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00653281	chr1:1991051	1	1991051	PRKCZ	Island	0.0028	None	0.0000097	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	-0.0036	0.00082	0.0000097	None	33450751_Mulder-RH_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	NEURL4 protein levels (SeqId = 13468-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEURL4 protein levels (SeqId = 13468-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuralized-like protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000097	None	Gadd-DA_neurl4_protein_levels__seqid___13468-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CUL4B protein levels (SeqId = 13743-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CUL4B protein levels (SeqId = 13743-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cullin-4B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000097	None	Gadd-DA_cul4b_protein_levels__seqid___13743-56__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GLRX2 protein levels (SeqId = 12486-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GLRX2 protein levels (SeqId = 12486-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutaredoxin-2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000097	None	Gadd-DA_glrx2_protein_levels__seqid___12486-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0389723	0.00880917	0.000009756006	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	-0.0380621	0.00860458	0.000009782949	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0581459	0.0131458	0.000009796747	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.01851	0.00407	0.0000098	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	MANF protein levels (SeqId = 9223-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MANF protein levels (SeqId = 9223-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mesencephalic astrocyte-derived neurotrophic factor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000098	None	Gadd-DA_manf_protein_levels__seqid___9223-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRPSAP1 protein levels (SeqId = 9478-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRPSAP1 protein levels (SeqId = 9478-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoribosyl pyrophosphate synthase-associated protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.0000098	None	Gadd-DA_prpsap1_protein_levels__seqid___9478-69__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	-0.0364866	0.00825107	0.00000984774	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0697496	0.0157803	0.000009938908	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06821641	chr1:2016915	1	2016915	PRKCZ	Open sea	0.00082	None	0.00001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	0.0049	None	0.00001	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	APLP2 protein levels (SeqId = 10627-87)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APLP2 protein levels (SeqId = 10627-87)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-like protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_aplp2_protein_levels__seqid___10627-87__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TIRAP protein levels (SeqId = 9839-148)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIRAP protein levels (SeqId = 9839-148)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Toll/interleukin-1 receptor domain-containing adapter protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_tirap_protein_levels__seqid___9839-148__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDC37 protein levels (SeqId = 3879-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDC37 protein levels (SeqId = 3879-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hsp90 co-chaperone Cdc37	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_cdc37_protein_levels__seqid___3879-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPKAPK3 protein levels (SeqId = 3822-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPKAPK3 protein levels (SeqId = 3822-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAP kinase-activated protein kinase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_mapkapk3_protein_levels__seqid___3822-54__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STIP1 protein levels (SeqId = 5489-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STIP1 protein levels (SeqId = 5489-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stress-induced-phosphoprotein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_stip1_protein_levels__seqid___5489-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PCNP protein levels (SeqId = 17769-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCNP protein levels (SeqId = 17769-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PEST proteolytic signal-containing nuclear protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_pcnp_protein_levels__seqid___17769-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL20 protein levels (SeqId = 4138-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL20 protein levels (SeqId = 4138-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-20	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_il20_protein_levels__seqid___4138-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NPPB protein levels (SeqId = 3723-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPPB protein levels (SeqId = 3723-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Natriuretic peptides B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_nppb_protein_levels__seqid___3723-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RGS10 protein levels (SeqId = 11634-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RGS10 protein levels (SeqId = 11634-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulator of G-protein signaling 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_rgs10_protein_levels__seqid___11634-32__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGI3 protein levels (SeqId = 8003-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGI3 protein levels (SeqId = 8003-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat LGI family member 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.619	0.14	0.00001	None	Gadd-DA_lgi3_protein_levels__seqid___8003-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRK protein levels (SeqId = 4976-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRK protein levels (SeqId = 4976-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adapter molecule crk	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.00001	None	Gadd-DA_crk_protein_levels__seqid___4976-57__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	0.056647	0.012821	0.00001001956	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Green BB	-	26771251	2016-08-01	Arsenic exposure	OBI_0002416	Placenta	Table S2	DNA methylation	Arsenic exposure	Offspring sex, maternal age, gestational age and cell counts	Beta values	mug/kg	Illumina HumanMethylation450	Placenta	Arsenic exposure was measured in the placenta	285	1	31.5	Females	European	cg05706173	chr1:2104310	1	2104310	PRKCZ	Open sea	-0.0031	7e-04	0.0000101	-	26771251_arsenic_exposure_placenta
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0364341	0.00825109	0.00001014172	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	0.99657	0.2258	0.0000102	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0364166	0.00825109	0.00001024168	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0364131	0.0082511	0.00001026163	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	-1.014538	0.23	0.0000103	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.0364015	0.0082511	0.00001032857	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.234593	0.0531802	0.0000103381	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0475521	0.0107812	0.00001037976	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0575789	0.0130554	0.00001039311	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg20457594	chr1:2109138	1	2109138	PRKCZ	Open sea	-0.00019737	4.45e-05	0.0000104	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0462695	0.0104942	0.00001045639	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0363737	0.00825111	0.00001049061	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.123879	0.0281038	0.00001050076	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0363636	0.00825111	0.00001054986	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0363577	0.00825111	0.00001058456	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0363445	0.00825112	0.00001066324	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0363444	0.00825112	0.00001066367	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0363096	0.00825113	0.00001087322	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.036298	0.00825113	0.00001094402	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.0372579	0.00846936	0.00001094461	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03395993	chr1:2109923	1	2109923	PRKCZ	Open sea	-0.00085	0.00019	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	None	None	0.000011	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13591369	chr1:2005564	1	2005564	PRKCZ	Island	-0.00074	0.00017	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-1.7	0.382	0.000011	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17355877	chr1:1998716	1	1998716	PRKCZ	Open sea	-0.01	0.0023	0.000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PNKP protein levels (SeqId = 13657-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNKP protein levels (SeqId = 13657-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bifunctional polynucleotide phosphatase/kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_pnkp_protein_levels__seqid___13657-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACSF2 protein levels (SeqId = 17466-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACSF2 protein levels (SeqId = 17466-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acyl-CoA synthetase family member 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_acsf2_protein_levels__seqid___17466-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CPXM1 protein levels (SeqId = 6255-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CPXM1 protein levels (SeqId = 6255-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable carboxypeptidase X1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_cpxm1_protein_levels__seqid___6255-74__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CNP protein levels (SeqId = 6609-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNP protein levels (SeqId = 6609-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_cnp_protein_levels__seqid___6609-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LAT2 protein levels (SeqId = 5613-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAT2 protein levels (SeqId = 5613-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Linker for activation of T-cells family member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.617	0.14	0.000011	None	Gadd-DA_lat2_protein_levels__seqid___5613-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KPNA6 protein levels (SeqId = 13969-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KPNA6 protein levels (SeqId = 13969-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Importin subunit alpha-7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_kpna6_protein_levels__seqid___13969-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HERC4 protein levels (SeqId = 7860-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HERC4 protein levels (SeqId = 7860-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable E3 ubiquitin-protein ligase HERC4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_herc4_protein_levels__seqid___7860-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MTHFD1 protein levels (SeqId = 12575-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTHFD1 protein levels (SeqId = 12575-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-1-tetrahydrofolate synthase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_mthfd1_protein_levels__seqid___12575-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRC37A2 protein levels (SeqId = 8897-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRC37A2 protein levels (SeqId = 8897-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat-containing protein 37A2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_lrrc37a2_protein_levels__seqid___8897-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDT2 protein levels (SeqId = 16583-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDT2 protein levels (SeqId = 16583-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_nudt2_protein_levels__seqid___16583-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACADSB protein levels (SeqId = 17403-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACADSB protein levels (SeqId = 17403-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_acadsb_protein_levels__seqid___17403-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK1 protein levels (SeqId = 3115-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK1 protein levels (SeqId = 3115-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_mapk1_protein_levels__seqid___3115-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDE11A protein levels (SeqId = 5252-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDE11A protein levels (SeqId = 5252-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_pde11a_protein_levels__seqid___5252-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HEXIM1 protein levels (SeqId = 15596-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HEXIM1 protein levels (SeqId = 15596-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein HEXIM1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_hexim1_protein_levels__seqid___15596-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB32 protein levels (SeqId = 17778-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB32 protein levels (SeqId = 17778-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-32	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_rab32_protein_levels__seqid___17778-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MLEC protein levels (SeqId = 6285-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MLEC protein levels (SeqId = 6285-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Malectin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_mlec_protein_levels__seqid___6285-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PABPN1 protein levels (SeqId = 8921-139)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PABPN1 protein levels (SeqId = 8921-139)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polyadenylate-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_pabpn1_protein_levels__seqid___8921-139__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MOBKL1A protein levels (SeqId = 19177-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MOBKL1A protein levels (SeqId = 19177-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MOB kinase activator 1B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_mobkl1a_protein_levels__seqid___19177-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PTGES2 protein levels (SeqId = 18458-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTGES2 protein levels (SeqId = 18458-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prostaglandin E synthase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000011	None	Gadd-DA_ptges2_protein_levels__seqid___18458-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSNK1D protein levels (SeqId = 11289-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSNK1D protein levels (SeqId = 11289-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Casein kinase I isoform delta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000011	None	Gadd-DA_csnk1d_protein_levels__seqid___11289-31__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	0.0022	None	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21282837	chr1:2104641	1	2104641	PRKCZ	Open sea	-0.135039	0.0307287	0.00001116503	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0362342	0.00825115	0.0000113405	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0362239	0.00825115	0.00001140591	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0361992	0.00825116	0.00001156415	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0361822	0.00825117	0.00001167417	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.0361597	0.00825117	0.0000118207	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0361441	0.00825118	0.00001192427	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0361342	0.00825118	0.00001198956	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.00089	0.0002	0.000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07196858	chr1:2085232	1	2085232	PRKCZ	South shelf	0.0057	None	0.000012	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	FAHD1 protein levels (SeqId = 17819-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAHD1 protein levels (SeqId = 17819-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acylpyruvase FAHD1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_fahd1_protein_levels__seqid___17819-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF4G2 protein levels (SeqId = 4230-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF4G2 protein levels (SeqId = 4230-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 4 gamma 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_eif4g2_protein_levels__seqid___4230-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NFU1 protein levels (SeqId = 7770-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NFU1 protein levels (SeqId = 7770-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.613	0.14	0.000012	None	Gadd-DA_nfu1_protein_levels__seqid___7770-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GPI protein levels (SeqId = 4272-46)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPI protein levels (SeqId = 4272-46)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glucose-6-phosphate isomerase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_gpi_protein_levels__seqid___4272-46__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB11 protein levels (SeqId = 7110-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB11 protein levels (SeqId = 7110-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 11	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_dnajb11_protein_levels__seqid___7110-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MUTED protein levels (SeqId = 19116-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MUTED protein levels (SeqId = 19116-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Biogenesis of lysosome-related organelles complex 1 subunit 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_muted_protein_levels__seqid___19116-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNX17 protein levels (SeqId = 12845-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNX17 protein levels (SeqId = 12845-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sorting nexin-17	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.62	0.14	0.000012	None	Gadd-DA_snx17_protein_levels__seqid___12845-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CASQ1 protein levels (SeqId = 11263-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CASQ1 protein levels (SeqId = 11263-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calsequestrin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_casq1_protein_levels__seqid___11263-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDM4 protein levels (SeqId = 12779-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDM4 protein levels (SeqId = 12779-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PR domain zinc finger protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_prdm4_protein_levels__seqid___12779-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGA2B protein levels (SeqId = 19574-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGA2B protein levels (SeqId = 19574-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin alpha-IIb|Integrin beta-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_itga2b_protein_levels__seqid___19574-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP2 protein levels (SeqId = 9339-204)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP2 protein levels (SeqId = 9339-204)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_fkbp2_protein_levels__seqid___9339-204__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	YARS protein levels (SeqId = 19270-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	YARS protein levels (SeqId = 19270-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_yars_protein_levels__seqid___19270-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCD1LG2 protein levels (SeqId = 3004-67)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCD1LG2 protein levels (SeqId = 3004-67)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Programmed cell death 1 ligand 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_pdcd1lg2_protein_levels__seqid___3004-67__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2F protein levels (SeqId = 18213-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2F protein levels (SeqId = 18213-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NEDD8-conjugating enzyme UBE2F	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_ube2f_protein_levels__seqid___18213-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRAT protein levels (SeqId = 12637-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRAT protein levels (SeqId = 12637-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carnitine O-acetyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000012	None	Gadd-DA_crat_protein_levels__seqid___12637-7__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	0.0033	None	0.000012	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0371862	0.00849247	0.00001202048	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.0361115	0.00825119	0.00001214203	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0360897	0.00825119	0.00001228992	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0360472	0.00825121	0.00001258362	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0470979	0.0107824	0.00001262371	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.101615	0.023264	0.00001262967	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0382507	0.00875735	0.00001263434	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06227939	chr1:2033594	1	2033594	PRKCZ	Open sea	0.0389455	0.00891759	0.0000126671	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0360347	0.00825121	0.00001267125	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.036033	0.00825121	0.00001268292	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0469365	0.01075	0.00001272951	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0434044	0.00994408	0.00001280821	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0384993	0.00882139	0.00001283971	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	0.138654	0.031779	0.00001289919	None	39706196_Hannah-M.-Smith_bmi_discovery
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-2.37	0.539	0.000013	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09180820	chr1:2113911	1	2113911	PRKCZ	North shelf	-0.00064	0.00015	0.000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.000052	0.000012	0.000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAD2 protein levels (SeqId = 10364-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAD2 protein levels (SeqId = 10364-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mothers against decapentaplegic homolog 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_smad2_protein_levels__seqid___10364-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF4H protein levels (SeqId = 5885-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF4H protein levels (SeqId = 5885-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 4H	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_eif4h_protein_levels__seqid___5885-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MYC protein levels (SeqId = 10362-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MYC protein levels (SeqId = 10362-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myc proto-oncogene protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.611	0.14	0.000013	None	Gadd-DA_myc_protein_levels__seqid___10362-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSMD1 protein levels (SeqId = 9598-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSMD1 protein levels (SeqId = 9598-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CUB and sushi domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_csmd1_protein_levels__seqid___9598-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IK protein levels (SeqId = 7207-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IK protein levels (SeqId = 7207-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein Red	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_ik_protein_levels__seqid___7207-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PA2G4 protein levels (SeqId = 4258-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PA2G4 protein levels (SeqId = 4258-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proliferation-associated protein 2G4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_pa2g4_protein_levels__seqid___4258-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCD6IP protein levels (SeqId = 18174-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCD6IP protein levels (SeqId = 18174-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Programmed cell death 6-interacting protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_pdcd6ip_protein_levels__seqid___18174-79__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PIP4K2B protein levels (SeqId = 18232-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PIP4K2B protein levels (SeqId = 18232-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_pip4k2b_protein_levels__seqid___18232-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TSG101 protein levels (SeqId = 13044-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TSG101 protein levels (SeqId = 13044-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor susceptibility gene 101 protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_tsg101_protein_levels__seqid___13044-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TPK1 protein levels (SeqId = 12018-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPK1 protein levels (SeqId = 12018-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thiamin pyrophosphokinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_tpk1_protein_levels__seqid___12018-84__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CHP1 protein levels (SeqId = 12458-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHP1 protein levels (SeqId = 12458-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcineurin B homologous protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_chp1_protein_levels__seqid___12458-79__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RBM17 protein levels (SeqId = 17391-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBM17 protein levels (SeqId = 17391-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Splicing factor 45	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_rbm17_protein_levels__seqid___17391-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF3G protein levels (SeqId = 11454-87)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF3G protein levels (SeqId = 11454-87)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 3 subunit G	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_eif3g_protein_levels__seqid___11454-87__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDOST protein levels (SeqId = 17161-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDOST protein levels (SeqId = 17161-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_ddost_protein_levels__seqid___17161-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC2L protein levels (SeqId = 8242-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC2L protein levels (SeqId = 8242-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 2 member L	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_clec2l_protein_levels__seqid___8242-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GAP43 protein levels (SeqId = 15325-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GAP43 protein levels (SeqId = 15325-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuromodulin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_gap43_protein_levels__seqid___15325-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GGPS1 protein levels (SeqId = 17786-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GGPS1 protein levels (SeqId = 17786-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Geranylgeranyl pyrophosphate synthase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.612	0.14	0.000013	None	Gadd-DA_ggps1_protein_levels__seqid___17786-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACADM protein levels (SeqId = 17333-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACADM protein levels (SeqId = 17333-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_acadm_protein_levels__seqid___17333-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C5orf46 protein levels (SeqId = 9100-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5orf46 protein levels (SeqId = 9100-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C5orf46	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_c5orf46_protein_levels__seqid___9100-32__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PEBP1 protein levels (SeqId = 4276-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PEBP1 protein levels (SeqId = 4276-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphatidylethanolamine-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000013	None	Gadd-DA_pebp1_protein_levels__seqid___4276-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CYB5R3 protein levels (SeqId = 7215-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CYB5R3 protein levels (SeqId = 7215-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NADH-cytochrome b5 reductase 3	774	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.93	0.214	0.000013	None	Gadd-DA_cyb5r3_protein_levels__seqid___7215-18__somascan_protein_measurement
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	-0.00021438	4.92e-05	0.0000134	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0359326	0.00825124	0.00001340807	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.037102	0.00852054	0.00001343245	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08510499	chr1:2071402	1	2071402	PRKCZ	Open sea	-0.0359265	0.00825124	0.00001345358	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-0.0357881	0.00822095	0.000013502	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0359084	0.00825125	0.00001358875	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0359042	0.00825125	0.00001362029	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	0.0560236	0.0128756	0.00001363376	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0358937	0.00825125	0.00001369987	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0370133	0.00850979	0.00001373733	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.035887	0.00825125	0.0000137507	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg04871460	chr1:1991521	1	1991521	PRKCZ	South shore	-	-	0.0000138	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0684965	0.0157558	0.00001387073	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0370943	0.00853266	0.00001387334	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0385701	0.00887376	0.00001392374	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0385822	0.00887765	0.00001395794	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0358589	0.00825126	0.0000139657	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0469117	0.0107949	0.00001397576	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RSRP1 protein levels (SeqId = 9050-170)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RSRP1 protein levels (SeqId = 9050-170)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Arginine/serine-rich protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_rsrp1_protein_levels__seqid___9050-170__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARHGAP1 protein levels (SeqId = 11955-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARHGAP1 protein levels (SeqId = 11955-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho GTPase-activating protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_arhgap1_protein_levels__seqid___11955-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPKAPK2 protein levels (SeqId = 3820-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPKAPK2 protein levels (SeqId = 3820-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAP kinase-activated protein kinase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_mapkapk2_protein_levels__seqid___3820-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TRIB2 protein levels (SeqId = 12363-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRIB2 protein levels (SeqId = 12363-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tribbles homolog 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_trib2_protein_levels__seqid___12363-70__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOA protein levels (SeqId = 5864-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOA protein levels (SeqId = 5864-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_aldoa_protein_levels__seqid___5864-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SBDS protein levels (SeqId = 3866-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SBDS protein levels (SeqId = 3866-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosome maturation protein SBDS	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_sbds_protein_levels__seqid___3866-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APRT protein levels (SeqId = 10088-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APRT protein levels (SeqId = 10088-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenine phosphoribosyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_aprt_protein_levels__seqid___10088-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRCH4 protein levels (SeqId = 11252-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRCH4 protein levels (SeqId = 11252-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat and calponin homology domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_lrch4_protein_levels__seqid___11252-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUGT1 protein levels (SeqId = 17818-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUGT1 protein levels (SeqId = 17818-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein SGT1 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_sugt1_protein_levels__seqid___17818-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADH5 protein levels (SeqId = 11369-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADH5 protein levels (SeqId = 11369-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alcohol dehydrogenase class-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_adh5_protein_levels__seqid___11369-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SELP protein levels (SeqId = 4154-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELP protein levels (SeqId = 4154-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: P-selectin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_selp_protein_levels__seqid___4154-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BACH1 protein levels (SeqId = 12451-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BACH1 protein levels (SeqId = 12451-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription regulator protein BACH1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_bach1_protein_levels__seqid___12451-62__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB121 protein levels (SeqId = 5765-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB121 protein levels (SeqId = 5765-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 121	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_defb121_protein_levels__seqid___5765-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDH1A3 protein levels (SeqId = 9835-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDH1A3 protein levels (SeqId = 9835-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldehyde dehydrogenase family 1 member A3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_aldh1a3_protein_levels__seqid___9835-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAEP protein levels (SeqId = 8867-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAEP protein levels (SeqId = 8867-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycodelin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_paep_protein_levels__seqid___8867-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APBB1 protein levels (SeqId = 12822-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APBB1 protein levels (SeqId = 12822-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_apbb1_protein_levels__seqid___12822-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NXF1 protein levels (SeqId = 12453-161)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NXF1 protein levels (SeqId = 12453-161)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear RNA export factor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_nxf1_protein_levels__seqid___12453-161__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ERP29 protein levels (SeqId = 13728-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ERP29 protein levels (SeqId = 13728-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endoplasmic reticulum resident protein 29	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_erp29_protein_levels__seqid___13728-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GFER protein levels (SeqId = 15398-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GFER protein levels (SeqId = 15398-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: FAD-linked sulfhydryl oxidase ALR	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_gfer_protein_levels__seqid___15398-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PYCR2 protein levels (SeqId = 18328-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PYCR2 protein levels (SeqId = 18328-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyrroline-5-carboxylate reductase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_pycr2_protein_levels__seqid___18328-36__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VPS4A protein levels (SeqId = 11476-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VPS4A protein levels (SeqId = 11476-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vacuolar protein sorting-associated protein 4A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000014	None	Gadd-DA_vps4a_protein_levels__seqid___11476-43__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26610624	chr1:1981268	1	1981268	PRKCZ	Island	0.00082	None	0.000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0358497	0.00825126	0.00001403662	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0358479	0.00825126	0.00001405068	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0683522	0.0157339	0.00001406857	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.12403	0.0285581	0.00001413089	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08064286	chr1:2092066	1	2092066	PRKCZ	Open sea	0.0358374	0.00825127	0.00001413276	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0358294	0.00825127	0.00001419534	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	0.0447263	0.0103003	0.00001419898	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0358096	0.00825128	0.00001435078	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0358093	0.00825128	0.00001435335	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	-0.224777	0.0518025	0.00001438238	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.035801	0.00825128	0.00001441961	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.042459	0.00978979	0.00001453606	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.0355038	0.00819611	0.00001488849	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0445745	0.0102916	0.00001493114	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0357375	0.0082513	0.00001493272	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg03754143	chr1:1981548	1	1981548	PRKCZ	Island	0.0079	0.00181	0.000015	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	-0.0055	0.0013	0.000015	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ARL11 protein levels (SeqId = 12433-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARL11 protein levels (SeqId = 12433-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-like protein 11	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_arl11_protein_levels__seqid___12433-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINI2 protein levels (SeqId = 7117-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINI2 protein levels (SeqId = 7117-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serpin I2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_serpini2_protein_levels__seqid___7117-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HARS protein levels (SeqId = 17450-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HARS protein levels (SeqId = 17450-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histidine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_hars_protein_levels__seqid___17450-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RTN4IP1 protein levels (SeqId = 18180-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RTN4IP1 protein levels (SeqId = 18180-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Reticulon-4-interacting protein 1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_rtn4ip1_protein_levels__seqid___18180-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CA13 protein levels (SeqId = 3420-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CA13 protein levels (SeqId = 3420-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbonic anhydrase 13	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_ca13_protein_levels__seqid___3420-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GCDH protein levels (SeqId = 19258-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GCDH protein levels (SeqId = 19258-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutaryl-CoA dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_gcdh_protein_levels__seqid___19258-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CIRBP protein levels (SeqId = 12724-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CIRBP protein levels (SeqId = 12724-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cold-inducible RNA-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_cirbp_protein_levels__seqid___12724-81__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FH protein levels (SeqId = 13384-110)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FH protein levels (SeqId = 13384-110)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fumarate hydratase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.607	0.14	0.000015	None	Gadd-DA_fh_protein_levels__seqid___13384-110__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIL1 protein levels (SeqId = 9884-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIL1 protein levels (SeqId = 9884-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase-like 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_ppil1_protein_levels__seqid___9884-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	QRFP protein levels (SeqId = 6463-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	QRFP protein levels (SeqId = 6463-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Orexigenic neuropeptide QRFP	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_qrfp_protein_levels__seqid___6463-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KCNMB3 protein levels (SeqId = 8905-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KCNMB3 protein levels (SeqId = 8905-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-activated potassium channel subunit beta-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_kcnmb3_protein_levels__seqid___8905-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TBPL1 protein levels (SeqId = 18434-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBPL1 protein levels (SeqId = 18434-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: TATA box-binding protein-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_tbpl1_protein_levels__seqid___18434-141__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARL6 protein levels (SeqId = 18415-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARL6 protein levels (SeqId = 18415-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-like protein 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_arl6_protein_levels__seqid___18415-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	YES1 protein levels (SeqId = 2878-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	YES1 protein levels (SeqId = 2878-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein kinase Yes	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_yes1_protein_levels__seqid___2878-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM59L protein levels (SeqId = 9959-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM59L protein levels (SeqId = 9959-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 59-like	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_tmem59l_protein_levels__seqid___9959-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TREML1 protein levels (SeqId = 9329-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREML1 protein levels (SeqId = 9329-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trem-like transcript 1 protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000015	None	Gadd-DA_treml1_protein_levels__seqid___9329-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NPFF protein levels (SeqId = 5617-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPFF protein levels (SeqId = 5617-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pro-FMRFamide-related neuropeptide FF	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.607	0.14	0.000015	None	Gadd-DA_npff_protein_levels__seqid___5617-41__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	3.4	0.785	0.000015	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.00094	0.00022	0.000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0357248	0.0082513	0.00001503714	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.035708	0.00825131	0.00001517673	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0357051	0.00825131	0.0000152015	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0356848	0.00825131	0.00001537181	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0356821	0.00825131	0.00001539454	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0391487	0.00905715	0.0000155351	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	-0.0356581	0.00825132	0.00001559879	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0421544	0.00975715	0.00001568021	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01164686	chr1:2024593	1	2024593	PRKCZ	North shore	0.193292	0.0447653	0.00001583959	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.243952	0.0565	0.000016	None	27105112_hiv_infection_cd4_tcells
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.019	0.0045	0.000016	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	ALKBH2 protein levels (SeqId = 18400-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALKBH2 protein levels (SeqId = 18400-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA oxidative demethylase ALKBH2	774	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.82	0.189	0.000016	None	Gadd-DA_alkbh2_protein_levels__seqid___18400-52__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10769649	chr1:2111330	1	2111330	PRKCZ	Open sea	-0.00095	0.00022	0.000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12764620	chr1:2025796	1	2025796	PRKCZ	Island	-0.00062	0.00014	0.000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	LEMD1 protein levels (SeqId = 8040-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LEMD1 protein levels (SeqId = 8040-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: LEM domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.604	0.14	0.000016	None	Gadd-DA_lemd1_protein_levels__seqid___8040-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	POGLUT1 protein levels (SeqId = 6467-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	POGLUT1 protein levels (SeqId = 6467-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein O-glucosyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_poglut1_protein_levels__seqid___6467-65__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SARS2 protein levels (SeqId = 12348-46)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SARS2 protein levels (SeqId = 12348-46)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine--tRNA ligase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_sars2_protein_levels__seqid___12348-46__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CGB2 protein levels (SeqId = 6213-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CGB2 protein levels (SeqId = 6213-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Choriogonadotropin subunit beta variant 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.603	0.14	0.000016	None	Gadd-DA_cgb2_protein_levels__seqid___6213-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BCL2L1 protein levels (SeqId = 4423-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BCL2L1 protein levels (SeqId = 4423-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bcl-2-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_bcl2l1_protein_levels__seqid___4423-77__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C11orf68 protein levels (SeqId = 8307-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C11orf68 protein levels (SeqId = 8307-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UPF0696 protein C11orf68	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_c11orf68_protein_levels__seqid___8307-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPS6KB1 protein levels (SeqId = 15608-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPS6KB1 protein levels (SeqId = 15608-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosomal protein S6 kinase beta-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_rps6kb1_protein_levels__seqid___15608-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GDI2 protein levels (SeqId = 2647-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GDI2 protein levels (SeqId = 2647-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rab GDP dissociation inhibitor beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_gdi2_protein_levels__seqid___2647-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SYTL4 protein levels (SeqId = 11563-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYTL4 protein levels (SeqId = 11563-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synaptotagmin-like protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.606	0.14	0.000016	None	Gadd-DA_sytl4_protein_levels__seqid___11563-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PGRMC2 protein levels (SeqId = 10506-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGRMC2 protein levels (SeqId = 10506-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Membrane-associated progesterone receptor component 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_pgrmc2_protein_levels__seqid___10506-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MLYCD protein levels (SeqId = 11538-216)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MLYCD protein levels (SeqId = 11538-216)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Malonyl-CoA decarboxylase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.605	0.14	0.000016	None	Gadd-DA_mlycd_protein_levels__seqid___11538-216__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VTA1 protein levels (SeqId = 4209-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VTA1 protein levels (SeqId = 4209-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vacuolar protein sorting-associated protein VTA1 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000016	None	Gadd-DA_vta1_protein_levels__seqid___4209-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DPYSL3 protein levels (SeqId = 12707-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DPYSL3 protein levels (SeqId = 12707-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dihydropyrimidinase-related protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000016	None	Gadd-DA_dpysl3_protein_levels__seqid___12707-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C11orf94 protein levels (SeqId = 8383-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C11orf94 protein levels (SeqId = 8383-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C11orf94	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.61	0.14	0.000016	None	Gadd-DA_c11orf94_protein_levels__seqid___8383-20__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20250605	chr1:2046506	1	2046506	PRKCZ	Island	0.001	None	0.000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-0.0356072	0.00825134	0.00001604099	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0407396	0.00944127	0.00001606107	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-0.0361986	0.00839211	0.00001618088	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-0.00081716	0.00018863	0.0000162	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24776480	chr1:2066446	1	2066446	PRKCZ	Island	0.219684	0.0509465	0.00001626411	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.0396504	0.0091965	0.00001632347	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06227939	chr1:2033594	1	2033594	PRKCZ	Open sea	-0.035565	0.00825135	0.00001641663	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0355633	0.00825135	0.00001643219	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0355506	0.00825135	0.00001654682	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	0.0355407	0.00825136	0.0000166369	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.259799	0.0603	0.0000167	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0355161	0.00825136	0.0000168623	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0382535	0.00888814	0.00001689201	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	0.0355073	0.00825137	0.00001694376	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0355036	0.00825137	0.00001697802	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00312809	chr1:2028213	1	2028213	PRKCZ	South shore	-1.6	0.383	0.000017	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.006	0.0013	0.000017	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	HOPX protein levels (SeqId = 19196-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HOPX protein levels (SeqId = 19196-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Homeodomain-only protein	774	1	Adults (18-65 years)	Both	European	cg19619416	chr1:1992232	1	1992232	PRKCZ	South shore	-0.97	0.226	0.000017	None	Gadd-DA_hopx_protein_levels__seqid___19196-73__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FHIT protein levels (SeqId = 9826-135)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FHIT protein levels (SeqId = 9826-135)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bis(5'-adenosyl)-triphosphatase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_fhit_protein_levels__seqid___9826-135__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRC59 protein levels (SeqId = 19163-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRC59 protein levels (SeqId = 19163-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat-containing protein 59	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_lrrc59_protein_levels__seqid___19163-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PFKFB3 protein levels (SeqId = 12456-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PFKFB3 protein levels (SeqId = 12456-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_pfkfb3_protein_levels__seqid___12456-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CACYBP protein levels (SeqId = 12432-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CACYBP protein levels (SeqId = 12432-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcyclin-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_cacybp_protein_levels__seqid___12432-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC17 protein levels (SeqId = 14655-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC17 protein levels (SeqId = 14655-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily C member 17	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_dnajc17_protein_levels__seqid___14655-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA0040 protein levels (SeqId = 14603-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA0040 protein levels (SeqId = 14603-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein KIAA0040	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_kiaa0040_protein_levels__seqid___14603-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNX8 protein levels (SeqId = 6925-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNX8 protein levels (SeqId = 6925-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sorting nexin-8	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_snx8_protein_levels__seqid___6925-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIA protein levels (SeqId = 3844-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIA protein levels (SeqId = 3844-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_ppia_protein_levels__seqid___3844-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PF4 protein levels (SeqId = 2697-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PF4 protein levels (SeqId = 2697-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet factor 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_pf4_protein_levels__seqid___2697-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MNX1 protein levels (SeqId = 9576-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MNX1 protein levels (SeqId = 9576-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Motor neuron and pancreas homeobox protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_mnx1_protein_levels__seqid___9576-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TFAM protein levels (SeqId = 9952-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TFAM protein levels (SeqId = 9952-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription factor A, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_tfam_protein_levels__seqid___9952-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIF protein levels (SeqId = 5248-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIF protein levels (SeqId = 5248-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_ppif_protein_levels__seqid___5248-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD47 protein levels (SeqId = 6653-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD47 protein levels (SeqId = 6653-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte surface antigen CD47	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000017	None	Gadd-DA_cd47_protein_levels__seqid___6653-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB14 protein levels (SeqId = 14283-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB14 protein levels (SeqId = 14283-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.603	0.14	0.000017	None	Gadd-DA_rab14_protein_levels__seqid___14283-12__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.04	0.00935	0.000017	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.0393194	0.00914181	0.00001710899	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0354819	0.00825137	0.00001718071	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.035477	0.00825137	0.00001722686	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.035454	0.00825138	0.00001744514	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	-0.199369	0.0464059	0.00001746575	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0580641	0.0135233	0.00001769081	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0354203	0.00825139	0.00001776872	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0354069	0.00825139	0.0000178991	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0354052	0.00825139	0.00001791554	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0353985	0.0082514	0.00001798167	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	COVID-19 Severity (Hospitalisation)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	COVID-19 Severity (Hospitalisation)	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	4232	1	Adults (18-65y)	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	0.097	0.0226	0.000018	None	Robert-F-Hillary_COVID-19_Severity_(Hospitalisation)_Fully-adjusted_model
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function decline	EFO_0004312, EFO_0003892	Discovery. FVC. Lung function decline in this paper is defined as a decrease in FVC between visits.	Table S1	Lung function decline	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	0.123	0.0287	0.000018	None	30343628_Carmona-JJ_lung_function_decline_discovery__fvc__lung_function_decline_in_this_paper_is_defined_as_a_decrease_in_fvc_between_visits_
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14204564	chr1:2018252	1	2018252	PRKCZ	Open sea	0.0059	None	0.000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	LCN1 protein levels (SeqId = 11708-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LCN1 protein levels (SeqId = 11708-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lipocalin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.602	0.14	0.000018	None	Gadd-DA_lcn1_protein_levels__seqid___11708-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DKK2 protein levels (SeqId = 15678-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DKK2 protein levels (SeqId = 15678-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dickkopf-related protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_dkk2_protein_levels__seqid___15678-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PCMT1 protein levels (SeqId = 18160-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCMT1 protein levels (SeqId = 18160-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_pcmt1_protein_levels__seqid___18160-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDE5A protein levels (SeqId = 5256-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDE5A protein levels (SeqId = 5256-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: cGMP-specific 3',5'-cyclic phosphodiesterase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_pde5a_protein_levels__seqid___5256-86__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TIAL1 protein levels (SeqId = 19131-184)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIAL1 protein levels (SeqId = 19131-184)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nucleolysin TIAR	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_tial1_protein_levels__seqid___19131-184__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPHK1 protein levels (SeqId = 4294-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPHK1 protein levels (SeqId = 4294-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sphingosine kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_sphk1_protein_levels__seqid___4294-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GSK3A protein levels (SeqId = 3441-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSK3A protein levels (SeqId = 3441-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycogen synthase kinase-3 alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_gsk3a_protein_levels__seqid___3441-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BCL2A1 protein levels (SeqId = 3413-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BCL2A1 protein levels (SeqId = 3413-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bcl-2-related protein A1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_bcl2a1_protein_levels__seqid___3413-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FLT3 protein levels (SeqId = 3437-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLT3 protein levels (SeqId = 3437-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Receptor-type tyrosine-protein kinase FLT3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_flt3_protein_levels__seqid___3437-80__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MESDC2 protein levels (SeqId = 15299-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MESDC2 protein levels (SeqId = 15299-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: LRP chaperone MESD	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_mesdc2_protein_levels__seqid___15299-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBQLN2 protein levels (SeqId = 19121-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBQLN2 protein levels (SeqId = 19121-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquilin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_ubqln2_protein_levels__seqid___19121-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK14 protein levels (SeqId = 5007-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK14 protein levels (SeqId = 5007-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000018	None	Gadd-DA_mapk14_protein_levels__seqid___5007-1__somascan_protein_measurement
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg13387826	chr1:2005260	1	2005260	PRKCZ	Island	-0.0002994	6.95e-05	0.0000181	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0657909	0.0153426	0.00001813491	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11227141	chr1:2003650	1	2003650	PRKCZ	North shore	-0.0353775	0.0082514	0.00001818888	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg12711627	chr1:2025769	1	2025769	PRKCZ	Island	-0.00025341	5.89e-05	0.0000184	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.00041673	9.68e-05	0.0000184	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.0353517	0.00825141	0.00001844648	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0395556	0.0092336	0.00001848323	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0353388	0.00825141	0.00001857689	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on older children	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	3049	5	6.8	Missing	European,African,Admixed,Other	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.022	0.005	0.0000186	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_older_children
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13591369	chr1:2005564	1	2005564	PRKCZ	Island	-0.3039	0.070989	0.00001871084	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	-0.037365	0.00872858	0.00001874363	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0353179	0.00825142	0.00001878896	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0353171	0.00825142	0.00001879718	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FDX1L protein levels (SeqId = 11231-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FDX1L protein levels (SeqId = 11231-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ferredoxin-2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg16653138	chr1:2005180	1	2005180	PRKCZ	Island	-0.59	0.138	0.000019	None	Gadd-DA_fdx1l_protein_levels__seqid___11231-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM150B protein levels (SeqId = 6284-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM150B protein levels (SeqId = 6284-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ALK and LTK ligand 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_fam150b_protein_levels__seqid___6284-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CASP3 protein levels (SeqId = 3593-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CASP3 protein levels (SeqId = 3593-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Caspase-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_casp3_protein_levels__seqid___3593-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB1 protein levels (SeqId = 3852-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB1 protein levels (SeqId = 3852-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_dnajb1_protein_levels__seqid___3852-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CETN3 protein levels (SeqId = 17410-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CETN3 protein levels (SeqId = 17410-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Centrin-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_cetn3_protein_levels__seqid___17410-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C19orf18 protein levels (SeqId = 9445-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C19orf18 protein levels (SeqId = 9445-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C19orf18	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_c19orf18_protein_levels__seqid___9445-44__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NDUFA5 protein levels (SeqId = 19200-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDUFA5 protein levels (SeqId = 19200-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.599	0.14	0.000019	None	Gadd-DA_ndufa5_protein_levels__seqid___19200-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MVK protein levels (SeqId = 11391-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MVK protein levels (SeqId = 11391-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mevalonate kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_mvk_protein_levels__seqid___11391-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDT3 protein levels (SeqId = 12796-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDT3 protein levels (SeqId = 12796-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Diphosphoinositol polyphosphate phosphohydrolase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_nudt3_protein_levels__seqid___12796-44__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PURB protein levels (SeqId = 18300-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PURB protein levels (SeqId = 18300-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcriptional activator protein Pur-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_purb_protein_levels__seqid___18300-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	USP21 protein levels (SeqId = 12681-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	USP21 protein levels (SeqId = 12681-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin carboxyl-terminal hydrolase 21	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_usp21_protein_levels__seqid___12681-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VPS24 protein levels (SeqId = 12508-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VPS24 protein levels (SeqId = 12508-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Charged multivesicular body protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_vps24_protein_levels__seqid___12508-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC12 protein levels (SeqId = 19334-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC12 protein levels (SeqId = 19334-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 12	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_txndc12_protein_levels__seqid___19334-62__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C1orf198 protein levels (SeqId = 8035-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1orf198 protein levels (SeqId = 8035-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C1orf198	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000019	None	Gadd-DA_c1orf198_protein_levels__seqid___8035-6__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20328379	chr1:2048946	1	2048946	PRKCZ	South shelf	0.013	0.003	0.000019	None	33450751_Mulder-RH_sex_discovery
Jiahui Si	China Kadoorie Biobank	34515027	Sep 13, 2021	coronary heart disease	None	discovery	dropbox	coronary heart disease	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Body mass index, Education, fasting time, marital status, smoking, alcohol consumption, physical activity, diet score.	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	982	1	Adults	Both	East Asian	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	0.0172	0.00401	0.000019	None	34515027_Jiahui-Si_coronary_heart_disease_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.26874	0.0628295	0.00001901949	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.140724	0.0329057	0.00001907994	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.036518	0.00854297	0.00001926642	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22128985	chr1:2089384	1	2089384	PRKCZ	Open sea	0.203042	0.0475072	0.00001931	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0352667	0.00825144	0.00001932042	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg20975074	chr1:2066430	1	2066430	PRKCZ	Island	-0.180046	0.0421344	0.00001937271	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13591369	chr1:2005564	1	2005564	PRKCZ	Island	-0.164682	0.0385413	0.00001939626	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Lunnon K	-	25129077	2014-08-17	Alzheimers disease Braak stage	EFO_0000249, EFO_0006801	Discovery in prefrontal cortex	Table S5	DNA methylation	Alzheimers disease Braak stage	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Prefrontal cortex	-	110	1	-	Missing	None	cg19900677	chr1:1999533	1	1999533	PRKCZ	Open sea	-	-	0.0000195	-	25129077_alzheimers_disease_braak_stage_discovery_in_prefrontal_cortex
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0352433	0.00825144	0.00001956761	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0352294	0.00825145	0.00001971555	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0352051	0.00825145	0.00001997795	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Battram T	GEO	25282492	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE61278. Compared fetal liver tissue to adult liver tissue of different individuals	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Fetal liver, adult liver	None	110	1	Adults	Both	European	cg00328210	chr1:1993016	1	1993016	PRKCZ	South shore	0.245	0.054	0.00002	None	25282492_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02361803	chr1:2014371	1	2014371	PRKCZ	Open sea	-0.00028843	6.73e-05	0.00002	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0074	0.0017	0.00002	None	33450751_Mulder-RH_sex_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.027	0.00624	0.00002	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mooney M.	None	32066674	2020-01-21	Attention deficit hyperactivity disorder	EFO_0003888	ADHD polygenic risk score	Table 2	DNA methylation	Attention deficit hyperactivity disorder	Age, sex, ancestry (genomic PCs), medication usage (binary variable signifying the history of psychoactive or stimulant medication), maternal smoking	Beta Values	None	Illumina HumanMethylationEPIC	Saliva	None	604	1	Children	Both	Unclear	cg14989962	chr1:2085717	1	2085717	PRKCZ	South shelf	0.0104	None	0.00002	ADHD polygenic risk score	32066674_Mooney-M._attention_deficit_hyperactivity_disorder_adhd_polygenic_risk_score
Gadd DA	Generation Scotland	35945220	31/07/2022	ARRB1 protein levels (SeqId = 12643-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARRB1 protein levels (SeqId = 12643-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-arrestin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_arrb1_protein_levels__seqid___12643-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DRG1 protein levels (SeqId = 17849-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DRG1 protein levels (SeqId = 17849-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Developmentally-regulated GTP-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_drg1_protein_levels__seqid___17849-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNUPN protein levels (SeqId = 17765-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNUPN protein levels (SeqId = 17765-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Snurportin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_snupn_protein_levels__seqid___17765-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX19A protein levels (SeqId = 18813-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX19A protein levels (SeqId = 18813-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ATP-dependent RNA helicase DDX19A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_ddx19a_protein_levels__seqid___18813-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UGP2 protein levels (SeqId = 13939-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UGP2 protein levels (SeqId = 13939-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UTP--glucose-1-phosphate uridylyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_ugp2_protein_levels__seqid___13939-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF1AY protein levels (SeqId = 19224-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF1AY protein levels (SeqId = 19224-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 1A, Y-chromosomal	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_eif1ay_protein_levels__seqid___19224-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL17B protein levels (SeqId = 3499-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL17B protein levels (SeqId = 3499-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-17B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_il17b_protein_levels__seqid___3499-77__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NDRG4 protein levels (SeqId = 7934-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDRG4 protein levels (SeqId = 7934-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein NDRG4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_ndrg4_protein_levels__seqid___7934-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NIT2 protein levels (SeqId = 17808-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NIT2 protein levels (SeqId = 17808-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Omega-amidase NIT2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_nit2_protein_levels__seqid___17808-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SCAMP5 protein levels (SeqId = 13509-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCAMP5 protein levels (SeqId = 13509-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Secretory carrier-associated membrane protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_scamp5_protein_levels__seqid___13509-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PABPC4 protein levels (SeqId = 12603-87)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PABPC4 protein levels (SeqId = 12603-87)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polyadenylate-binding protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_pabpc4_protein_levels__seqid___12603-87__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPP2R5A protein levels (SeqId = 13622-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPP2R5A protein levels (SeqId = 13622-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.00002	None	Gadd-DA_ppp2r5a_protein_levels__seqid___13622-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0352019	0.00825145	0.00002001254	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.0351059	0.00823132	0.00002012322	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.205684	0.0483	0.0000203	None	27105112_hiv_infection_cd4_tcells
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.0567292	0.0133125	0.00002032	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0351684	0.00825146	0.0000203794	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.0351662	0.00825146	0.00002040379	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0351649	0.00825147	0.00002041876	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0351613	0.00825147	0.00002045894	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0432742	0.0101591	0.00002060159	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0351465	0.00825147	0.00002062276	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	0.035141	0.00825147	0.00002068437	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0351229	0.00825148	0.00002088841	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0848944	0.0199444	0.00002088962	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM9 protein levels (SeqId = 8597-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM9 protein levels (SeqId = 8597-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 9	774	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-1.12	0.262	0.000021	None	Gadd-DA_tmem9_protein_levels__seqid___8597-1__somascan_protein_measurement
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.00285	0.00067	0.000021	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.78	0.183	0.000021	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	WWOX protein levels (SeqId = 17724-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WWOX protein levels (SeqId = 17724-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WW domain-containing oxidoreductase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000021	None	Gadd-DA_wwox_protein_levels__seqid___17724-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MTIF3 protein levels (SeqId = 7852-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTIF3 protein levels (SeqId = 7852-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Translation initiation factor IF-3, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_mtif3_protein_levels__seqid___7852-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PARP16 protein levels (SeqId = 7881-244)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PARP16 protein levels (SeqId = 7881-244)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein mono-ADP-ribosyltransferase PARP16	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_parp16_protein_levels__seqid___7881-244__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPIE protein levels (SeqId = 5238-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPIE protein levels (SeqId = 5238-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase E	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_ppie_protein_levels__seqid___5238-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNRD1 protein levels (SeqId = 13967-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNRD1 protein levels (SeqId = 13967-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin reductase 1, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_txnrd1_protein_levels__seqid___13967-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	COMMD9 protein levels (SeqId = 17683-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COMMD9 protein levels (SeqId = 17683-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: COMM domain-containing protein 9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_commd9_protein_levels__seqid___17683-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RNF122 protein levels (SeqId = 11160-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNF122 protein levels (SeqId = 11160-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RING finger protein 122	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_rnf122_protein_levels__seqid___11160-56__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NHEJ1 protein levels (SeqId = 11351-233)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NHEJ1 protein levels (SeqId = 11351-233)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Non-homologous end-joining factor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000021	None	Gadd-DA_nhej1_protein_levels__seqid___11351-233__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21221161	chr1:1999183	1	1999183	PRKCZ	Open sea	0.00084	None	0.000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINF2 protein levels (SeqId = 3024-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINF2 protein levels (SeqId = 3024-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-2-antiplasmin	774	1	Adults (18-65 years)	Both	European	cg23803603	chr1:2058230	1	2058230	PRKCZ	Open sea	-0.58	0.136	0.000021	None	Gadd-DA_serpinf2_protein_levels__seqid___3024-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	0.0415628	0.00976997	0.00002111562	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0350933	0.00825149	0.00002122684	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.035093	0.00825149	0.00002123029	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01974180	chr1:2084246	1	2084246	PRKCZ	South shore	0.126634	0.0297839	0.00002132183	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0350828	0.00825149	0.00002134745	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	0.11902	0.0279991	0.0000214082	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06757383	chr1:2008579	1	2008579	PRKCZ	South shelf	-0.0350741	0.00825149	0.00002144782	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0350661	0.00825149	0.00002154167	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0350449	0.0082515	0.00002178915	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	0.0350365	0.0082515	0.00002188883	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	-0.00062401	0.00014636	0.0000219	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.0350335	0.0082515	0.00002192378	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0350331	0.0082515	0.00002192886	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	0.0073	0.0017	0.000022	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0052	0.0012	0.000022	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	None	None	0.000022	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11781622	chr1:2041072	1	2041072	PRKCZ	Island	0.0035	None	0.000022	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ACOT13 protein levels (SeqId = 17675-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACOT13 protein levels (SeqId = 17675-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acyl-coenzyme A thioesterase 13	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_acot13_protein_levels__seqid___17675-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMD10 protein levels (SeqId = 18385-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMD10 protein levels (SeqId = 18385-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 26S proteasome non-ATPase regulatory subunit 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000022	None	Gadd-DA_psmd10_protein_levels__seqid___18385-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK3 protein levels (SeqId = 2855-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK3 protein levels (SeqId = 2855-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_mapk3_protein_levels__seqid___2855-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TBCB protein levels (SeqId = 17686-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBCB protein levels (SeqId = 17686-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tubulin-folding cofactor B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000022	None	Gadd-DA_tbcb_protein_levels__seqid___17686-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDH6A1 protein levels (SeqId = 19136-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDH6A1 protein levels (SeqId = 19136-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_aldh6a1_protein_levels__seqid___19136-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TPMT protein levels (SeqId = 11218-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPMT protein levels (SeqId = 11218-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thiopurine S-methyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000022	None	Gadd-DA_tpmt_protein_levels__seqid___11218-84__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB3D protein levels (SeqId = 19379-154)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB3D protein levels (SeqId = 19379-154)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-3D	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_rab3d_protein_levels__seqid___19379-154__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DARS2 protein levels (SeqId = 12395-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DARS2 protein levels (SeqId = 12395-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aspartate--tRNA ligase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_dars2_protein_levels__seqid___12395-86__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SARS protein levels (SeqId = 18178-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SARS protein levels (SeqId = 18178-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_sars_protein_levels__seqid___18178-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TARS protein levels (SeqId = 18186-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TARS protein levels (SeqId = 18186-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Threonine--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000022	None	Gadd-DA_tars_protein_levels__seqid___18186-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD74 protein levels (SeqId = 8748-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD74 protein levels (SeqId = 8748-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: HLA class II histocompatibility antigen gamma chain	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.6	0.14	0.000022	None	Gadd-DA_cd74_protein_levels__seqid___8748-45__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0350234	0.00825151	0.00002204385	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05620928	chr1:2011702	1	2011702	PRKCZ	Open sea	0.050402	0.0118774	0.00002213916	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0350092	0.00825151	0.00002221368	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0456541	0.0107605	0.0000222137	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-0.0356417	0.00840276	0.00002232315	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0349693	0.00825152	0.00002269808	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0349661	0.00825152	0.00002273692	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0349614	0.00825152	0.00002279415	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0417808	0.00986229	0.0000228498	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06717814	chr1:2038593	1	2038593	PRKCZ	Island	-0.165628	0.0391074	0.00002294598	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	IL5RA protein levels (SeqId = 13686-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL5RA protein levels (SeqId = 13686-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-5 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-1.1	0.26	0.000023	None	Gadd-DA_il5ra_protein_levels__seqid___13686-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AIP protein levels (SeqId = 3839-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AIP protein levels (SeqId = 3839-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: AH receptor-interacting protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_aip_protein_levels__seqid___3839-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RELT protein levels (SeqId = 14112-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RELT protein levels (SeqId = 14112-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 19L	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_relt_protein_levels__seqid___14112-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ATAD1 protein levels (SeqId = 6625-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ATAD1 protein levels (SeqId = 6625-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ATPase family AAA domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_atad1_protein_levels__seqid___6625-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAT1 protein levels (SeqId = 10370-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAT1 protein levels (SeqId = 10370-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal transducer and activator of transcription 1-alpha/beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_stat1_protein_levels__seqid___10370-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SATB1 protein levels (SeqId = 13511-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SATB1 protein levels (SeqId = 13511-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-binding protein SATB1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_satb1_protein_levels__seqid___13511-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	XRCC4 protein levels (SeqId = 9886-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	XRCC4 protein levels (SeqId = 9886-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA repair protein XRCC4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_xrcc4_protein_levels__seqid___9886-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SCGB1D2 protein levels (SeqId = 6508-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCGB1D2 protein levels (SeqId = 6508-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Secretoglobin family 1D member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_scgb1d2_protein_levels__seqid___6508-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IRAK4 protein levels (SeqId = 18162-167)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IRAK4 protein levels (SeqId = 18162-167)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-1 receptor-associated kinase 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_irak4_protein_levels__seqid___18162-167__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TAF15 protein levels (SeqId = 16865-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAF15 protein levels (SeqId = 16865-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: TATA-binding protein-associated factor 2N	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_taf15_protein_levels__seqid___16865-62__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX19B protein levels (SeqId = 5460-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX19B protein levels (SeqId = 5460-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ATP-dependent RNA helicase DDX19B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_ddx19b_protein_levels__seqid___5460-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CILP protein levels (SeqId = 5717-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CILP protein levels (SeqId = 5717-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cartilage intermediate layer protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_cilp_protein_levels__seqid___5717-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZPBP protein levels (SeqId = 8635-283)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZPBP protein levels (SeqId = 8635-283)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zona pellucida-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_zpbp_protein_levels__seqid___8635-283__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DTD1 protein levels (SeqId = 19194-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DTD1 protein levels (SeqId = 19194-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: D-aminoacyl-tRNA deacylase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_dtd1_protein_levels__seqid___19194-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VPS4B protein levels (SeqId = 12668-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VPS4B protein levels (SeqId = 12668-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vacuolar protein sorting-associated protein 4B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000023	None	Gadd-DA_vps4b_protein_levels__seqid___12668-7__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.0014	None	0.000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.135851	0.0320807	0.00002300653	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01974180	chr1:2084246	1	2084246	PRKCZ	South shore	0.0349342	0.00825153	0.00002313129	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08510499	chr1:2071402	1	2071402	PRKCZ	Open sea	-0.0349335	0.00825153	0.00002313996	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0341103	0.00805832	0.00002320702	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	0.212498	0.0502149	0.00002330463	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0349164	0.00825154	0.00002335434	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0348675	0.00825155	0.00002397782	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	-0.0348664	0.00825155	0.00002399149	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Paulina Jedynak	EDEN French birth cohort	34523531	Aug 21, 2021	Pregnancy exposure to Triclosan	CHEBI_33853	Unadjusted for cell counts	EDEN French birth cohort	DNA methylation	Pregnancy exposure to Triclosan	Age, Smoking, Batch effects, Education, center of recruitment, parity, season of conception	Beta values	None	Illumina HumanMethylation450	Placenta	None	202	1	Infants (< 4 years)	Males	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.0041	0.00097	0.000024	None	34523531_Paulina-Jedynak_pregnancy_exposure_to_triclosan_unadjusted_for_cell_counts
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJA2 protein levels (SeqId = 11582-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJA2 protein levels (SeqId = 11582-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily A member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.592	0.14	0.000024	None	Gadd-DA_dnaja2_protein_levels__seqid___11582-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STMN2 protein levels (SeqId = 10900-272)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STMN2 protein levels (SeqId = 10900-272)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stathmin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_stmn2_protein_levels__seqid___10900-272__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRMT3 protein levels (SeqId = 12696-166)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRMT3 protein levels (SeqId = 12696-166)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein arginine N-methyltransferase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_prmt3_protein_levels__seqid___12696-166__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL2RG protein levels (SeqId = 2634-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL2RG protein levels (SeqId = 2634-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytokine receptor common subunit gamma	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_il2rg_protein_levels__seqid___2634-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KLHL7 protein levels (SeqId = 12625-138)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLHL7 protein levels (SeqId = 12625-138)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kelch-like protein 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_klhl7_protein_levels__seqid___12625-138__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SAR1A protein levels (SeqId = 17726-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SAR1A protein levels (SeqId = 17726-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GTP-binding protein SAR1a	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_sar1a_protein_levels__seqid___17726-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDX6 protein levels (SeqId = 5018-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDX6 protein levels (SeqId = 5018-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxiredoxin-6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_prdx6_protein_levels__seqid___5018-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NMT1 protein levels (SeqId = 5196-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMT1 protein levels (SeqId = 5196-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycylpeptide N-tetradecanoyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_nmt1_protein_levels__seqid___5196-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LAP3 protein levels (SeqId = 13959-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAP3 protein levels (SeqId = 13959-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytosol aminopeptidase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000024	None	Gadd-DA_lap3_protein_levels__seqid___13959-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NADK protein levels (SeqId = 13624-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NADK protein levels (SeqId = 13624-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NAD kinase	774	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-1.03	0.244	0.000024	None	Gadd-DA_nadk_protein_levels__seqid___13624-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CPQ protein levels (SeqId = 9394-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CPQ protein levels (SeqId = 9394-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carboxypeptidase Q	774	1	Adults (18-65 years)	Both	European	cg06834951	chr1:2099649	1	2099649	PRKCZ	Open sea	-0.88	0.21	0.000024	None	Gadd-DA_cpq_protein_levels__seqid___9394-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	-0.0348634	0.00825155	0.00002403096	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06227939	chr1:2033594	1	2033594	PRKCZ	Open sea	0.0348501	0.00825156	0.00002420378	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0348393	0.00825156	0.0000243439	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0348362	0.00825156	0.00002438561	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0348343	0.00825156	0.00002440977	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00660626	chr1:2107451	1	2107451	PRKCZ	Open sea	0.169968	0.0402799	0.00002459046	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0348061	0.00825157	0.00002478333	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0456699	0.010828	0.00002482428	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0347996	0.00825157	0.00002486919	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	0.0038	None	0.000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB4A protein levels (SeqId = 16883-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB4A protein levels (SeqId = 16883-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-4A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_rab4a_protein_levels__seqid___16883-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARID3A protein levels (SeqId = 3875-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARID3A protein levels (SeqId = 3875-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: AT-rich interactive domain-containing protein 3A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_arid3a_protein_levels__seqid___3875-62__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ERAP1 protein levels (SeqId = 4964-67)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ERAP1 protein levels (SeqId = 4964-67)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endoplasmic reticulum aminopeptidase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_erap1_protein_levels__seqid___4964-67__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBQLN4 protein levels (SeqId = 12720-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBQLN4 protein levels (SeqId = 12720-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquilin-4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_ubqln4_protein_levels__seqid___12720-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TOLLIP protein levels (SeqId = 13963-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TOLLIP protein levels (SeqId = 13963-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Toll-interacting protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_tollip_protein_levels__seqid___13963-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AIDA protein levels (SeqId = 17347-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AIDA protein levels (SeqId = 17347-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Axin interactor, dorsalization-associated protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000025	None	Gadd-DA_aida_protein_levels__seqid___17347-80__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	0.015	0.0036	0.000025	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.0360849	0.00856491	0.00002533888	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0347608	0.00825158	0.00002539319	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0965669	0.0229314	0.00002541	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19255464	chr1:2047101	1	2047101	PRKCZ	South shore	0.0347573	0.00825158	0.00002544104	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg12711627	chr1:2025769	1	2025769	PRKCZ	Island	-0.232384	0.0552	0.0000255	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0347462	0.00825159	0.00002559327	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.0347429	0.00825159	0.00002563851	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0617444	0.0146715	0.00002586303	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	-0.001	0.00025	0.000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NACA protein levels (SeqId = 3854-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NACA protein levels (SeqId = 3854-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nascent polypeptide-associated complex subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_naca_protein_levels__seqid___3854-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BAD protein levels (SeqId = 5870-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BAD protein levels (SeqId = 5870-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bcl2-associated agonist of cell death	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_bad_protein_levels__seqid___5870-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RMDN1 protein levels (SeqId = 7096-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RMDN1 protein levels (SeqId = 7096-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulator of microtubule dynamics protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_rmdn1_protein_levels__seqid___7096-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RUFY1 protein levels (SeqId = 11425-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RUFY1 protein levels (SeqId = 11425-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RUN and FYVE domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_rufy1_protein_levels__seqid___11425-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PCBD2 protein levels (SeqId = 6899-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCBD2 protein levels (SeqId = 6899-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pterin-4-alpha-carbinolamine dehydratase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_pcbd2_protein_levels__seqid___6899-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NCR2 protein levels (SeqId = 2734-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCR2 protein levels (SeqId = 2734-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Natural cytotoxicity triggering receptor 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000026	None	Gadd-DA_ncr2_protein_levels__seqid___2734-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0347163	0.00825159	0.00002600611	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.0390215	0.00927647	0.00002608887	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0390352	0.00928225	0.00002622095	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.034686	0.0082516	0.00002643267	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.231168	0.055	0.0000265	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	0.0346536	0.00825161	0.00002689536	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0346464	0.00825161	0.00002699828	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ICOSLG protein levels (SeqId = 5061-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICOSLG protein levels (SeqId = 5061-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ICOS ligand	774	1	Adults (18-65 years)	Both	European	cg18803110	chr1:2057439	1	2057439	PRKCZ	Open sea	-0.48	0.114	0.000027	None	Gadd-DA_icoslg_protein_levels__seqid___5061-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPP1CC protein levels (SeqId = 19295-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPP1CC protein levels (SeqId = 19295-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_ppp1cc_protein_levels__seqid___19295-32__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAPA protein levels (SeqId = 4292-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAPA protein levels (SeqId = 4292-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-soluble NSF attachment protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_napa_protein_levels__seqid___4292-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PABPC3 protein levels (SeqId = 10447-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PABPC3 protein levels (SeqId = 10447-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polyadenylate-binding protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_pabpc3_protein_levels__seqid___10447-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PFDN2 protein levels (SeqId = 19243-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PFDN2 protein levels (SeqId = 19243-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prefoldin subunit 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.589	0.14	0.000027	None	Gadd-DA_pfdn2_protein_levels__seqid___19243-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFAIP8 protein levels (SeqId = 12563-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFAIP8 protein levels (SeqId = 12563-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor alpha-induced protein 8	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_tnfaip8_protein_levels__seqid___12563-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RGS19 protein levels (SeqId = 12713-365)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RGS19 protein levels (SeqId = 12713-365)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulator of G-protein signaling 19	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_rgs19_protein_levels__seqid___12713-365__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDLIM1 protein levels (SeqId = 11428-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDLIM1 protein levels (SeqId = 11428-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PDZ and LIM domain protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000027	None	Gadd-DA_pdlim1_protein_levels__seqid___11428-31__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22712840	chr1:2026193	1	2026193	PRKCZ	Island	-0.0019	0.00045	0.000027	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.222603	0.0530202	0.00002700945	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00095688	chr1:2003864	1	2003864	PRKCZ	North shore	-0.0346387	0.00825162	0.0000271095	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0346385	0.00825162	0.00002711216	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0346299	0.00825162	0.00002723848	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.034611	0.00825162	0.00002751443	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	0.0346101	0.00825162	0.00002752813	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0450253	0.0107385	0.00002770382	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03754143	chr1:1981548	1	1981548	PRKCZ	Island	-0.923407	0.2203	0.0000278	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0345791	0.00825163	0.00002798694	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UBC protein levels (SeqId = 6647-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBC protein levels (SeqId = 6647-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polyubiquitin-C	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_ubc_protein_levels__seqid___6647-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AGFG1 protein levels (SeqId = 11681-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AGFG1 protein levels (SeqId = 11681-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Arf-GAP domain and FG repeat-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_agfg1_protein_levels__seqid___11681-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DMKN protein levels (SeqId = 5963-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DMKN protein levels (SeqId = 5963-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dermokine	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.588	0.14	0.000028	None	Gadd-DA_dmkn_protein_levels__seqid___5963-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GPX7 protein levels (SeqId = 8345-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPX7 protein levels (SeqId = 8345-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione peroxidase 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_gpx7_protein_levels__seqid___8345-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SKIL protein levels (SeqId = 14670-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SKIL protein levels (SeqId = 14670-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ski-like protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_skil_protein_levels__seqid___14670-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SHC1 protein levels (SeqId = 16043-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHC1 protein levels (SeqId = 16043-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SHC-transforming protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_shc1_protein_levels__seqid___16043-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCDC90B protein levels (SeqId = 7792-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCDC90B protein levels (SeqId = 7792-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coiled-coil domain-containing protein 90B, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_ccdc90b_protein_levels__seqid___7792-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CFL1 protein levels (SeqId = 4203-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CFL1 protein levels (SeqId = 4203-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cofilin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_cfl1_protein_levels__seqid___4203-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	INPP5E protein levels (SeqId = 11370-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	INPP5E protein levels (SeqId = 11370-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 72 kDa inositol polyphosphate 5-phosphatase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_inpp5e_protein_levels__seqid___11370-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPE protein levels (SeqId = 12646-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPE protein levels (SeqId = 12646-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribulose-phosphate 3-epimerase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_rpe_protein_levels__seqid___12646-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF2RB protein levels (SeqId = 11137-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF2RB protein levels (SeqId = 11137-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytokine receptor common subunit beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_csf2rb_protein_levels__seqid___11137-43__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STMN3 protein levels (SeqId = 8019-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STMN3 protein levels (SeqId = 8019-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stathmin-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000028	None	Gadd-DA_stmn3_protein_levels__seqid___8019-73__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0345728	0.00825164	0.00002808235	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0566532	0.0135267	0.00002827361	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0345589	0.00825164	0.00002829181	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.034546	0.00825164	0.00002848628	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.041	0.0099	0.000029	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	TACO1 protein levels (SeqId = 9257-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TACO1 protein levels (SeqId = 9257-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Translational activator of cytochrome c oxidase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000029	None	Gadd-DA_taco1_protein_levels__seqid___9257-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PITPNA protein levels (SeqId = 9934-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PITPNA protein levels (SeqId = 9934-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphatidylinositol transfer protein alpha isoform	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_pitpna_protein_levels__seqid___9934-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	WDR5 protein levels (SeqId = 17760-128)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WDR5 protein levels (SeqId = 17760-128)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WD repeat-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_wdr5_protein_levels__seqid___17760-128__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GNAI1 protein levels (SeqId = 19271-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNAI1 protein levels (SeqId = 19271-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanine nucleotide-binding protein G(i) subunit alpha-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.586	0.14	0.000029	None	Gadd-DA_gnai1_protein_levels__seqid___19271-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNTA1 protein levels (SeqId = 19274-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNTA1 protein levels (SeqId = 19274-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-1-syntrophin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_snta1_protein_levels__seqid___19274-80__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARL6IP5 protein levels (SeqId = 13503-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARL6IP5 protein levels (SeqId = 13503-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PRA1 family protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_arl6ip5_protein_levels__seqid___13503-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DKK1 protein levels (SeqId = 3535-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DKK1 protein levels (SeqId = 3535-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dickkopf-related protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000029	None	Gadd-DA_dkk1_protein_levels__seqid___3535-84__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKT1 protein levels (SeqId = 3392-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKT1 protein levels (SeqId = 3392-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RAC-gamma serine/threonine-protein kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_akt1_protein_levels__seqid___3392-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TIAM1 protein levels (SeqId = 14035-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIAM1 protein levels (SeqId = 14035-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphoma invasion and metastasis-inducing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.586	0.14	0.000029	None	Gadd-DA_tiam1_protein_levels__seqid___14035-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TOR1AIP1 protein levels (SeqId = 10606-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TOR1AIP1 protein levels (SeqId = 10606-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Torsin-1A-interacting protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_tor1aip1_protein_levels__seqid___10606-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAC3 protein levels (SeqId = 16769-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAC3 protein levels (SeqId = 16769-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related C3 botulinum toxin substrate 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.000029	None	Gadd-DA_rac3_protein_levels__seqid___16769-20__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	0.86	0.206	0.000029	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	0.034505	0.00825165	0.000029117	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0345017	0.00825166	0.00002916843	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	0.0345013	0.00825166	0.00002917426	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0344918	0.00825166	0.00002932238	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0409425	0.00979826	0.00002950699	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	-0.0344656	0.00825167	0.00002973446	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0344554	0.00825167	0.00002989564	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0344553	0.00825167	0.00002989719	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0344552	0.00825167	0.00002989925	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13387826	chr1:2005260	1	2005260	PRKCZ	Island	-0.00049	0.00012	0.00003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM106A protein levels (SeqId = 10499-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM106A protein levels (SeqId = 10499-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 106A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_tmem106a_protein_levels__seqid___10499-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP6 protein levels (SeqId = 12529-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP6 protein levels (SeqId = 12529-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inactive peptidyl-prolyl cis-trans isomerase FKBP6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_fkbp6_protein_levels__seqid___12529-32__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EEF1D protein levels (SeqId = 17826-341)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EEF1D protein levels (SeqId = 17826-341)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Elongation factor 1-delta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_eef1d_protein_levels__seqid___17826-341__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TREML1 protein levels (SeqId = 11147-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREML1 protein levels (SeqId = 11147-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trem-like transcript 1 protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_treml1_protein_levels__seqid___11147-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DYNLL2 protein levels (SeqId = 11493-169)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DYNLL2 protein levels (SeqId = 11493-169)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dynein light chain 2, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_dynll2_protein_levels__seqid___11493-169__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NDUFV2 protein levels (SeqId = 7748-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDUFV2 protein levels (SeqId = 7748-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00003	None	Gadd-DA_ndufv2_protein_levels__seqid___7748-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAB2 protein levels (SeqId = 13680-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAB2 protein levels (SeqId = 13680-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NGFI-A-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.59	0.14	0.00003	None	Gadd-DA_nab2_protein_levels__seqid___13680-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07196858	chr1:2085232	1	2085232	PRKCZ	South shelf	0.0344268	0.00825168	0.00003035501	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00666247	chr1:2028044	1	2028044	PRKCZ	South shore	-0.183874	0.0440783	0.00003040287	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0344174	0.00825168	0.0000305066	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0344117	0.00825168	0.00003059905	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	0.0344113	0.00825168	0.00003060513	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0343693	0.00824484	0.00003082498	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.0343954	0.00825169	0.0000308655	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.072252	0.0173356	0.00003092712	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05463656	chr1:1992687	1	1992687	PRKCZ	South shore	-0.0005	0.00012	0.000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.0031	7e-04	0.000031	-	27651444_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	-0.00307	0.00074	0.000031	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14989962	chr1:2085717	1	2085717	PRKCZ	South shelf	0.0012	None	0.000031	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	None	None	0.000031	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2T protein levels (SeqId = 12400-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2T protein levels (SeqId = 12400-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 T	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_ube2t_protein_levels__seqid___12400-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PTPN9 protein levels (SeqId = 12633-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTPN9 protein levels (SeqId = 12633-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein phosphatase non-receptor type 9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_ptpn9_protein_levels__seqid___12633-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RLN3 protein levels (SeqId = 6027-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RLN3 protein levels (SeqId = 6027-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Relaxin-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_rln3_protein_levels__seqid___6027-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSNK2A1 protein levels (SeqId = 5225-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSNK2A1 protein levels (SeqId = 5225-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Casein kinase II subunit beta|Casein kinase II subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_csnk2a1_protein_levels__seqid___5225-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STMN1 protein levels (SeqId = 17367-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STMN1 protein levels (SeqId = 17367-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stathmin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_stmn1_protein_levels__seqid___17367-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSNK2A1 protein levels (SeqId = 3427-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSNK2A1 protein levels (SeqId = 3427-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Casein kinase II subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000031	None	Gadd-DA_csnk2a1_protein_levels__seqid___3427-63__somascan_protein_measurement
Tan Q	Middle<U+2010>aged Danish Twins (MADT)	34427971	Aug 24, 2021	Age	EFO_0000246	Discovery	Table S1	DNA methylation	Age	Cell composition (reference based)	M values	years	Illumina HumanMethylation450	Whole blood	None	492	1	Geriatrics	Males	European	cg22942532	chr1:2089924	1	2089924	PRKCZ	Open sea	0.0083	0.00191	0.000031	None	34427971_Tan-Q_age_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0429733	0.0103136	0.0000310879	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0343781	0.00825169	0.00003115038	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.082569	0.0198351	0.00003161931	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	0.0358144	0.00860509	0.00003172669	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08064286	chr1:2092066	1	2092066	PRKCZ	Open sea	0.0343407	0.0082517	0.00003177574	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0448131	0.010771	0.00003193226	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	-0.0565361	0.0135899	0.00003198423	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.0015	None	0.000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	MPL protein levels (SeqId = 3473-78)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MPL protein levels (SeqId = 3473-78)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thrombopoietin receptor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_mpl_protein_levels__seqid___3473-78__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OVCA2 protein levels (SeqId = 17697-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OVCA2 protein levels (SeqId = 17697-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Esterase OVCA2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_ovca2_protein_levels__seqid___17697-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB2 protein levels (SeqId = 11438-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB2 protein levels (SeqId = 11438-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_dnajb2_protein_levels__seqid___11438-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TSLP protein levels (SeqId = 3010-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TSLP protein levels (SeqId = 3010-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thymic stromal lymphopoietin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_tslp_protein_levels__seqid___3010-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDC42BPB protein levels (SeqId = 3629-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDC42BPB protein levels (SeqId = 3629-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase MRCK beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_cdc42bpb_protein_levels__seqid___3629-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPL protein levels (SeqId = 8011-96)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPL protein levels (SeqId = 8011-96)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acid phosphatase type 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_papl_protein_levels__seqid___8011-96__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PGLS protein levels (SeqId = 17799-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGLS protein levels (SeqId = 17799-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 6-phosphogluconolactonase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000032	None	Gadd-DA_pgls_protein_levels__seqid___17799-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0343242	0.00825171	0.0000320558	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11335286	chr1:2086528	1	2086528	PRKCZ	South shelf	0.0343196	0.00825171	0.00003213307	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0343189	0.00825171	0.00003214551	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0369764	0.00889244	0.00003226064	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0343108	0.00825171	0.00003228441	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0582022	0.013998	0.00003230346	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.0343085	0.00825171	0.00003232394	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0343075	0.00825171	0.00003234008	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	0.0342966	0.00825171	0.00003252745	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.18499	0.0445	0.0000326	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	0.0342862	0.00825172	0.00003270836	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0365117	0.00878847	0.00003278413	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01514357	chr1:2105392	1	2105392	PRKCZ	Open sea	-0.00019	0.000046	0.000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	BLVRA protein levels (SeqId = 11382-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BLVRA protein levels (SeqId = 11382-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Biliverdin reductase A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000033	None	Gadd-DA_blvra_protein_levels__seqid___11382-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBLCP1 protein levels (SeqId = 19124-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBLCP1 protein levels (SeqId = 19124-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like domain-containing CTD phosphatase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000033	None	Gadd-DA_ublcp1_protein_levels__seqid___19124-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RBBP9 protein levels (SeqId = 10064-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBBP9 protein levels (SeqId = 10064-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Putative hydrolase RBBP9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000033	None	Gadd-DA_rbbp9_protein_levels__seqid___10064-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CNN2 protein levels (SeqId = 18877-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNN2 protein levels (SeqId = 18877-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calponin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000033	None	Gadd-DA_cnn2_protein_levels__seqid___18877-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IMPDH2 protein levels (SeqId = 5250-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IMPDH2 protein levels (SeqId = 5250-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inosine-5'-monophosphate dehydrogenase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000033	None	Gadd-DA_impdh2_protein_levels__seqid___5250-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0449783	0.0108309	0.00003303425	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	-0.0649599	0.0156431	0.00003305424	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.03846	0.00926205	0.00003308293	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	0.034264	0.00825172	0.00003309506	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.0342476	0.00825173	0.00003338402	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.0342475	0.00825173	0.00003338563	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	0.0342433	0.00825173	0.00003345908	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	-0.178178	0.043	0.0000335	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0379431	0.00914564	0.00003361585	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	0.0342337	0.00825173	0.00003362916	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.256598	0.0618631	0.0000337232	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.132377	0.0319168	0.00003376492	None	39706196_Hannah-M.-Smith_body_fat_discovery
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg08115172	chr1:1990868	1	1990868	PRKCZ	Island	-0.00016177	3.88e-05	0.0000338	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07797073	chr1:1982791	1	1982791	PRKCZ	Island	-0.0086	0.0021	0.000034	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.0059	0.0014	0.000034	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PDCD5 protein levels (SeqId = 12517-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDCD5 protein levels (SeqId = 12517-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Programmed cell death protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_pdcd5_protein_levels__seqid___12517-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	G3BP2 protein levels (SeqId = 9831-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	G3BP2 protein levels (SeqId = 9831-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras GTPase-activating protein-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_g3bp2_protein_levels__seqid___9831-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAP1L2 protein levels (SeqId = 13529-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAP1L2 protein levels (SeqId = 13529-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nucleosome assembly protein 1-like 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_nap1l2_protein_levels__seqid___13529-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AREG protein levels (SeqId = 2970-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AREG protein levels (SeqId = 2970-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amphiregulin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_areg_protein_levels__seqid___2970-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DOK2 protein levels (SeqId = 19578-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DOK2 protein levels (SeqId = 19578-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Docking protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_dok2_protein_levels__seqid___19578-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ERP44 protein levels (SeqId = 6064-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ERP44 protein levels (SeqId = 6064-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endoplasmic reticulum resident protein 44	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000034	None	Gadd-DA_erp44_protein_levels__seqid___6064-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FGFR4 protein levels (SeqId = 4988-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGFR4 protein levels (SeqId = 4988-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroblast growth factor receptor 4	774	1	Adults (18-65 years)	Both	European	cg22626579	chr1:2038628	1	2038628	PRKCZ	Island	-0.79	0.191	0.000034	None	Gadd-DA_fgfr4_protein_levels__seqid___4988-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	0.0341945	0.00825174	0.00003433467	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	1.7	0.405	0.000035	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	HS3ST3A1 protein levels (SeqId = 8268-98)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HS3ST3A1 protein levels (SeqId = 8268-98)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_hs3st3a1_protein_levels__seqid___8268-98__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RALA protein levels (SeqId = 14332-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RALA protein levels (SeqId = 14332-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Ral-A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_rala_protein_levels__seqid___14332-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APEX1 protein levels (SeqId = 9849-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APEX1 protein levels (SeqId = 9849-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-(apurinic or apyrimidinic site) lyase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_apex1_protein_levels__seqid___9849-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DCTD protein levels (SeqId = 17756-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DCTD protein levels (SeqId = 17756-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Deoxycytidylate deaminase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_dctd_protein_levels__seqid___17756-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKCB protein levels (SeqId = 5475-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKCB protein levels (SeqId = 5475-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein kinase C beta type	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_prkcb_protein_levels__seqid___5475-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FLRT3 protein levels (SeqId = 9128-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLRT3 protein levels (SeqId = 9128-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane protein FLRT3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_flrt3_protein_levels__seqid___9128-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BNIP3L protein levels (SeqId = 7835-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BNIP3L protein levels (SeqId = 7835-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_bnip3l_protein_levels__seqid___7835-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANPEP protein levels (SeqId = 15457-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANPEP protein levels (SeqId = 15457-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminopeptidase N	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000035	None	Gadd-DA_anpep_protein_levels__seqid___15457-14__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	0.00098	None	0.000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25845463	chr1:2064046	1	2064046	PRKCZ	Island	-0.0012	0.00028	0.000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	0.0341544	0.00825175	0.00003507039	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0341495	0.00825176	0.00003516034	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0558295	0.0134916	0.00003521583	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0341359	0.00825176	0.00003541501	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0341347	0.00825176	0.00003543617	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0341315	0.00825176	0.00003549697	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.034129	0.00825176	0.00003554343	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0341238	0.00825176	0.00003564017	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0713648	0.0172587	0.0000356903	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09322616	chr1:2040400	1	2040400	PRKCZ	North shore	0.0341191	0.00825176	0.00003572921	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE3A protein levels (SeqId = 11226-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE3A protein levels (SeqId = 11226-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-protein ligase E3A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_ube3a_protein_levels__seqid___11226-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APBB2 protein levels (SeqId = 12753-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APBB2 protein levels (SeqId = 12753-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amyloid-beta A4 precursor protein-binding family B member 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_apbb2_protein_levels__seqid___12753-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADGRF1 protein levels (SeqId = 11243-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADGRF1 protein levels (SeqId = 11243-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adhesion G-protein coupled receptor F1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_adgrf1_protein_levels__seqid___11243-90__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNRNPDL protein levels (SeqId = 10852-114)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNRNPDL protein levels (SeqId = 10852-114)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heterogeneous nuclear ribonucleoprotein D-like	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_hnrnpdl_protein_levels__seqid___10852-114__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NMT2 protein levels (SeqId = 17821-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMT2 protein levels (SeqId = 17821-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycylpeptide N-tetradecanoyltransferase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_nmt2_protein_levels__seqid___17821-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	JMJD6 protein levels (SeqId = 18322-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	JMJD6 protein levels (SeqId = 18322-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_jmjd6_protein_levels__seqid___18322-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DLL3 protein levels (SeqId = 9974-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DLL3 protein levels (SeqId = 9974-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Delta-like protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_dll3_protein_levels__seqid___9974-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF175 protein levels (SeqId = 12716-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF175 protein levels (SeqId = 12716-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 175	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_znf175_protein_levels__seqid___12716-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARHGAP5 protein levels (SeqId = 14748-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARHGAP5 protein levels (SeqId = 14748-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho GTPase-activating protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_arhgap5_protein_levels__seqid___14748-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXLNA protein levels (SeqId = 15698-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXLNA protein levels (SeqId = 15698-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-taxilin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000036	None	Gadd-DA_txlna_protein_levels__seqid___15698-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	-0.0341015	0.00825177	0.00003606326	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	-0.0340982	0.00825177	0.00003612603	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0606273	0.0146731	0.00003618288	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.0340925	0.00825177	0.0000362353	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.0340921	0.00825177	0.00003624207	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0404867	0.00980252	0.00003644044	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.0340637	0.00825178	0.00003678801	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0340627	0.00825178	0.0000368073	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.034058	0.00825178	0.00003689864	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LILRB4 protein levels (SeqId = 6453-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LILRB4 protein levels (SeqId = 6453-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte immunoglobulin-like receptor subfamily B member 4	774	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.6	0.144	0.000037	None	Gadd-DA_lilrb4_protein_levels__seqid___6453-70__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	0.0041	0.001	0.000037	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.24	0.0578	0.000037	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	RAC2 protein levels (SeqId = 18950-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAC2 protein levels (SeqId = 18950-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related C3 botulinum toxin substrate 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000037	None	Gadd-DA_rac2_protein_levels__seqid___18950-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSDE1 protein levels (SeqId = 12735-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSDE1 protein levels (SeqId = 12735-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cold shock domain-containing protein E1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000037	None	Gadd-DA_csde1_protein_levels__seqid___12735-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APOA1BP protein levels (SeqId = 16621-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOA1BP protein levels (SeqId = 16621-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NAD(P)H-hydrate epimerase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000037	None	Gadd-DA_apoa1bp_protein_levels__seqid___16621-77__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AP1S2 protein levels (SeqId = 18405-117)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AP1S2 protein levels (SeqId = 18405-117)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: AP-1 complex subunit sigma-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000037	None	Gadd-DA_ap1s2_protein_levels__seqid___18405-117__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RNGTT protein levels (SeqId = 12847-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNGTT protein levels (SeqId = 12847-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: mRNA-capping enzyme	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000037	None	Gadd-DA_rngtt_protein_levels__seqid___12847-27__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg09651011	chr1:2091677	1	2091677	PRKCZ	Open sea	0.7	0.169	0.000037	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0340519	0.00825178	0.00003701762	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0340404	0.00825179	0.00003724325	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00130343	chr1:2032156	1	2032156	PRKCZ	Open sea	-0.0340372	0.00825179	0.00003730489	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	-0.0340351	0.00825179	0.00003734648	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.183066	0.0444	0.0000374	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0340245	0.00825179	0.00003755522	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0387618	0.00940315	0.00003773185	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	-0.0340075	0.0082518	0.00003789285	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	0.0033	0.00076	0.000038	None	33564054_Kashima-K_gestational_age
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.031	0.00743	0.000038	None	Robert-F-Hillary_Incident_COPD_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14255243	chr1:2010660	1	2010660	PRKCZ	Open sea	-0.00063	0.00015	0.000038	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18877309	chr1:2105343	1	2105343	PRKCZ	Open sea	0.0037	None	0.000038	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	FGF7 protein levels (SeqId = 4487-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGF7 protein levels (SeqId = 4487-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroblast growth factor 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000038	None	Gadd-DA_fgf7_protein_levels__seqid___4487-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0339903	0.0082518	0.00003823772	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	0.0349211	0.00847887	0.00003832664	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	-0.0029	0.00069	0.000039	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	IDI1 protein levels (SeqId = 17712-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IDI1 protein levels (SeqId = 17712-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Isopentenyl-diphosphate Delta-isomerase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_idi1_protein_levels__seqid___17712-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DARS protein levels (SeqId = 12675-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DARS protein levels (SeqId = 12675-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aspartate--tRNA ligase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_dars_protein_levels__seqid___12675-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF5A protein levels (SeqId = 5888-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF5A protein levels (SeqId = 5888-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 5A-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_eif5a_protein_levels__seqid___5888-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUMO3 protein levels (SeqId = 14623-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUMO3 protein levels (SeqId = 14623-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small ubiquitin-related modifier 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_sumo3_protein_levels__seqid___14623-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD300LF protein levels (SeqId = 5623-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD300LF protein levels (SeqId = 5623-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMRF35-like molecule 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_cd300lf_protein_levels__seqid___5623-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C9orf89 protein levels (SeqId = 7778-104)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C9orf89 protein levels (SeqId = 7778-104)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Caspase recruitment domain-containing protein 19	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_c9orf89_protein_levels__seqid___7778-104__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AGAP2 protein levels (SeqId = 14291-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AGAP2 protein levels (SeqId = 14291-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_agap2_protein_levels__seqid___14291-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMA1 protein levels (SeqId = 7880-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMA1 protein levels (SeqId = 7880-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit alpha type-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000039	None	Gadd-DA_psma1_protein_levels__seqid___7880-9__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19906777	chr1:2023482	1	2023482	PRKCZ	North shore	0.003	None	0.000039	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-1.12	0.27	0.000039	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	0.0339474	0.00825181	0.00003911074	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.033946	0.00825181	0.00003913877	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.0371564	0.00903421	0.00003929246	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0339374	0.00825182	0.00003931671	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	-0.0339366	0.00825182	0.00003933287	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0715117	0.0173911	0.00003944408	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0352285	0.00856759	0.00003946571	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27642710	chr1:2076778	1	2076778	PRKCZ	Open sea	-0.0339298	0.00825182	0.00003947363	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0339277	0.00825182	0.0000395167	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	0.0339256	0.00825182	0.00003955954	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg23803603	chr1:2058230	1	2058230	PRKCZ	Open sea	-0.00036541	8.85e-05	0.0000396	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0339215	0.00825182	0.00003964609	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03395993	chr1:2109923	1	2109923	PRKCZ	Open sea	0.031	0.00766	0.00004	None	Robert-F-Hillary_Incident_COPD_Basic_model
Kazmi N	PACE	31230546	2019-06-24	Hypertensive disorders of pregnancy	MONDO_0024664, EFO_0000537, EFO_0000668	Meta analysis unadjusted model	Table S3	DNA methylation	Hypertensive disorders of pregnancy	None	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	5242	10	Infants	Both	Unclear	cg05929117	chr1:1983033	1	1983033	PRKCZ	Island	-0.0063	0.0015	0.00004	None	31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model
Battram T	GEO	25282492	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE61278. Compared fetal liver tissue to adult liver tissue of different individuals	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Fetal liver, adult liver	None	110	1	Adults	Both	European	cg07836663	chr1:2066167	1	2066167	PRKCZ	North shore	-0.362	0.084	0.00004	None	25282492_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12601506	chr1:2017918	1	2017918	PRKCZ	Open sea	-0.00043	0.00011	0.00004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	C11orf73 protein levels (SeqId = 8686-342)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C11orf73 protein levels (SeqId = 8686-342)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein Hikeshi	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.575	0.14	0.00004	None	Gadd-DA_c11orf73_protein_levels__seqid___8686-342__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BAG1 protein levels (SeqId = 17195-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BAG1 protein levels (SeqId = 17195-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BAG family molecular chaperone regulator 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00004	None	Gadd-DA_bag1_protein_levels__seqid___17195-43__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OLA1 protein levels (SeqId = 12659-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OLA1 protein levels (SeqId = 12659-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Obg-like ATPase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00004	None	Gadd-DA_ola1_protein_levels__seqid___12659-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ULBP2 protein levels (SeqId = 3082-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ULBP2 protein levels (SeqId = 3082-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UL16-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.00004	None	Gadd-DA_ulbp2_protein_levels__seqid___3082-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08064286	chr1:2092066	1	2092066	PRKCZ	Open sea	-0.033903	0.00825183	0.00004003296	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0557407	0.0135739	0.00004039525	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0338724	0.00825183	0.00004068066	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01974180	chr1:2084246	1	2084246	PRKCZ	South shore	0.0333212	0.00811948	0.00004085068	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.03664	0.00892822	0.00004085555	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22942532	chr1:2089924	1	2089924	PRKCZ	Open sea	-0.033859	0.00825184	0.00004096588	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	-0.0338576	0.00825184	0.0000409974	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06757383	chr1:2008579	1	2008579	PRKCZ	South shelf	0.0015	None	0.000041	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PMEL protein levels (SeqId = 6472-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMEL protein levels (SeqId = 6472-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocyte protein PMEL	774	1	Adults (18-65 years)	Both	European	cg15550572	chr1:2064441	1	2064441	PRKCZ	North shore	-0.44	0.106	0.000041	None	Gadd-DA_pmel_protein_levels__seqid___6472-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM119 protein levels (SeqId = 11110-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM119 protein levels (SeqId = 11110-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 119	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000041	None	Gadd-DA_tmem119_protein_levels__seqid___11110-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IFNA14 protein levels (SeqId = 7180-114)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFNA14 protein levels (SeqId = 7180-114)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon alpha-14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000041	None	Gadd-DA_ifna14_protein_levels__seqid___7180-114__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C17orf78 protein levels (SeqId = 6571-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C17orf78 protein levels (SeqId = 6571-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C17orf78	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000041	None	Gadd-DA_c17orf78_protein_levels__seqid___6571-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FGB protein levels (SeqId = 18890-227)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGB protein levels (SeqId = 18890-227)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibrinogen beta chain	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.58	0.14	0.000041	None	Gadd-DA_fgb_protein_levels__seqid___18890-227__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PIN1 protein levels (SeqId = 15474-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PIN1 protein levels (SeqId = 15474-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000041	None	Gadd-DA_pin1_protein_levels__seqid___15474-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IST1 protein levels (SeqId = 12434-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IST1 protein levels (SeqId = 12434-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: IST1 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000041	None	Gadd-DA_ist1_protein_levels__seqid___12434-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PLXNA4 protein levels (SeqId = 19560-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLXNA4 protein levels (SeqId = 19560-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plexin-A4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000041	None	Gadd-DA_plxna4_protein_levels__seqid___19560-23__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0631698	0.0154062	0.00004148689	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13077150	chr1:2004222	1	2004222	PRKCZ	North shore	0.0338321	0.00825184	0.00004154828	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0338285	0.00825185	0.00004162668	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.0338271	0.00825185	0.00004165719	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.142762	0.0348297	0.00004171066	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0338165	0.00825185	0.0000418881	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TYK2 protein levels (SeqId = 5260-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TYK2 protein levels (SeqId = 5260-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Non-receptor tyrosine-protein kinase TYK2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_tyk2_protein_levels__seqid___5260-80__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMX3 protein levels (SeqId = 5654-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMX3 protein levels (SeqId = 5654-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase TMX3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.575	0.14	0.000042	None	Gadd-DA_tmx3_protein_levels__seqid___5654-70__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GHRL protein levels (SeqId = 6518-85)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GHRL protein levels (SeqId = 6518-85)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Appetite-regulating hormone	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.573	0.14	0.000042	None	Gadd-DA_ghrl_protein_levels__seqid___6518-85__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUN5 protein levels (SeqId = 11260-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUN5 protein levels (SeqId = 11260-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SUN domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_sun5_protein_levels__seqid___11260-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PILRA protein levels (SeqId = 8825-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PILRA protein levels (SeqId = 8825-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Paired immunoglobulin-like type 2 receptor alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_pilra_protein_levels__seqid___8825-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C2orf66 protein levels (SeqId = 5677-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C2orf66 protein levels (SeqId = 5677-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C2orf66	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_c2orf66_protein_levels__seqid___5677-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ISOC1 protein levels (SeqId = 9816-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISOC1 protein levels (SeqId = 9816-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Isochorismatase domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_isoc1_protein_levels__seqid___9816-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCDC50 protein levels (SeqId = 12399-194)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCDC50 protein levels (SeqId = 12399-194)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coiled-coil domain-containing protein 50	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.574	0.14	0.000042	None	Gadd-DA_ccdc50_protein_levels__seqid___12399-194__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MANBA protein levels (SeqId = 6382-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MANBA protein levels (SeqId = 6382-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-mannosidase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_manba_protein_levels__seqid___6382-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIF3A protein levels (SeqId = 13961-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIF3A protein levels (SeqId = 13961-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kinesin-like protein KIF3A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000042	None	Gadd-DA_kif3a_protein_levels__seqid___13961-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0338041	0.00825185	0.00004216105	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.0337917	0.00825186	0.00004243559	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannon E	-	27572077	2016-08-30	Schizophrenia	EFO_0000692	Phase 1	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	675	1	-	Missing	European	cg11796233	chr1:2060236	1	2060236	PRKCZ	North shelf	-0.009394	0.002295	0.0000425	-	27572077_schizophrenia_phase_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0337827	0.00825186	0.00004263676	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0337716	0.00825186	0.00004288459	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB14 protein levels (SeqId = 8053-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB14 protein levels (SeqId = 8053-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000043	None	Gadd-DA_dnajb14_protein_levels__seqid___8053-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EDF1 protein levels (SeqId = 12415-122)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EDF1 protein levels (SeqId = 12415-122)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endothelial differentiation-related factor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000043	None	Gadd-DA_edf1_protein_levels__seqid___12415-122__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDAC8 protein levels (SeqId = 2859-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDAC8 protein levels (SeqId = 2859-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone deacetylase 8	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000043	None	Gadd-DA_hdac8_protein_levels__seqid___2859-69__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23629792	chr1:1987129	1	1987129	PRKCZ	North shelf	0.0029	None	0.000043	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.0337568	0.00825187	0.00004321688	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0441576	0.0107968	0.00004338915	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20975074	chr1:2066430	1	2066430	PRKCZ	Island	-0.0337446	0.00825187	0.00004349417	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0337387	0.00825187	0.00004362779	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PROS1 protein levels (SeqId = 2700-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PROS1 protein levels (SeqId = 2700-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vitamin K-dependent protein S	774	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-1.07	0.261	0.000044	None	Gadd-DA_pros1_protein_levels__seqid___2700-56__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PMM1 protein levels (SeqId = 17408-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMM1 protein levels (SeqId = 17408-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphomannomutase 1	774	1	Adults (18-65 years)	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.621	0.152	0.000044	None	Gadd-DA_pmm1_protein_levels__seqid___17408-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANXA7 protein levels (SeqId = 18244-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANXA7 protein levels (SeqId = 18244-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Annexin A7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_anxa7_protein_levels__seqid___18244-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PARK7 protein levels (SeqId = 19523-215)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PARK7 protein levels (SeqId = 19523-215)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein/nucleic acid deglycase DJ-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_park7_protein_levels__seqid___19523-215__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ST3GAL2 protein levels (SeqId = 6281-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ST3GAL2 protein levels (SeqId = 6281-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_st3gal2_protein_levels__seqid___6281-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDK8 protein levels (SeqId = 3359-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDK8 protein levels (SeqId = 3359-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase 8|Cyclin-C	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_cdk8_protein_levels__seqid___3359-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPG21 protein levels (SeqId = 11122-97)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPG21 protein levels (SeqId = 11122-97)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Maspardin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_spg21_protein_levels__seqid___11122-97__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLC30A5 protein levels (SeqId = 9594-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLC30A5 protein levels (SeqId = 9594-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc transporter 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_slc30a5_protein_levels__seqid___9594-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARPC3 protein levels (SeqId = 13573-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARPC3 protein levels (SeqId = 13573-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Actin-related protein 2/3 complex subunit 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_arpc3_protein_levels__seqid___13573-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KCNF1 protein levels (SeqId = 12834-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KCNF1 protein levels (SeqId = 12834-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Potassium voltage-gated channel subfamily F member 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000044	None	Gadd-DA_kcnf1_protein_levels__seqid___12834-3__somascan_protein_measurement
Amélie Taschereau	Gen3G	37386647	Jun 29, 2023	glucose 1h post OGTT	None	None	None	DNA methylation	glucose 1h post OGTT	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Gestational age, Gravidity	M values	mmol/L	Illumina HumanMethylationEPIC	Umbilical cord blood cells at birth and blood cells at 5y visit	Only CpGs with p<1x10E-4 were uploaded (COMBAT was used to correct for batch effect)	539	1	Infants	Both	European	cg23629792	chr1:1987129	1	1987129	PRKCZ	North shelf	0.021	0.005	0.000044	None	37386647_Taschereau-A_glucose_1h_post_ogtt
Gadd DA	Generation Scotland	35945220	31/07/2022	MXRA7 protein levels (SeqId = 8005-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MXRA7 protein levels (SeqId = 8005-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Matrix-remodeling-associated protein 7	774	1	Adults (18-65 years)	Both	European	cg26252027	chr1:2012218	1	2012218	PRKCZ	Open sea	-0.8	0.196	0.000044	None	Gadd-DA_mxra7_protein_levels__seqid___8005-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0337181	0.00825188	0.0000440986	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0337102	0.00825188	0.00004428174	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0811822	0.019889	0.00004493265	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.0336818	0.00825189	0.00004494372	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	0.034	0.008	0.000045	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	ISCU protein levels (SeqId = 7201-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISCU protein levels (SeqId = 7201-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_iscu_protein_levels__seqid___7201-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNRPA protein levels (SeqId = 12678-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNRPA protein levels (SeqId = 12678-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: U1 small nuclear ribonucleoprotein A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_snrpa_protein_levels__seqid___12678-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CAPN3 protein levels (SeqId = 12385-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAPN3 protein levels (SeqId = 12385-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calpain-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_capn3_protein_levels__seqid___12385-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EFS protein levels (SeqId = 12572-236)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFS protein levels (SeqId = 12572-236)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Embryonal Fyn-associated substrate	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IGBP1 protein levels (SeqId = 12358-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGBP1 protein levels (SeqId = 12358-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Immunoglobulin-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_igbp1_protein_levels__seqid___12358-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR1B1 protein levels (SeqId = 16606-85)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR1B1 protein levels (SeqId = 16606-85)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldo-keto reductase family 1 member B1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000045	None	Gadd-DA_akr1b1_protein_levels__seqid___16606-85__somascan_protein_measurement
Eze Inkenna	SCSAP, LHDA	32484729	2020-06-01	Particulate matter air pollution	EFO_0007908, EFO_0008255	None	Table S6	DNA methylation	Particulate matter air pollution	Age, sex, educational attainment, smoking, passive smoking, alcohol, fruit intake, vegetable intake, body mass index, exercise level, asthma status, batch effects, cell composition (reference free), socioeconomic position, greenness index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	1389	1	Adults	Both	Unclear	cg23682913	chr1:2080710	1	2080710	PRKCZ	North shore	0.0093	0.00229	0.000045	None	32484729_Eze-Inkenna_particulate_matter_air_pollution
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.0357711	0.00876479	0.00004503572	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	0.035128	0.00860795	0.00004510288	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0570026	0.0139697	0.00004518722	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09322616	chr1:2040400	1	2040400	PRKCZ	North shore	0.0336702	0.00825259	0.00004528368	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.058268	0.0142828	0.00004535422	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17426766	chr1:2046864	1	2046864	PRKCZ	Island	0.0336595	0.00825189	0.0000454684	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	-0.0336595	0.00825189	0.00004546886	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0336581	0.00825189	0.00004550153	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0336573	0.00825189	0.00004552131	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.175165	0.0429491	0.0000455452	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19619416	chr1:1992232	1	1992232	PRKCZ	South shore	-0.175158	0.0429581	0.00004573425	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.06887	0.0168906	0.00004577922	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18888671	chr1:2030462	1	2030462	PRKCZ	Open sea	-0.00796	0.00191	0.000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	TCEA2 protein levels (SeqId = 13481-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TCEA2 protein levels (SeqId = 13481-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription elongation factor A protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.569	0.14	0.000046	None	Gadd-DA_tcea2_protein_levels__seqid___13481-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB22A protein levels (SeqId = 12408-333)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB22A protein levels (SeqId = 12408-333)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-22A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.571	0.14	0.000046	None	Gadd-DA_rab22a_protein_levels__seqid___12408-333__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0336356	0.0082519	0.00004603903	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	-0.0344946	0.00846366	0.00004613404	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02912476	chr1:2035087	1	2035087	PRKCZ	North shelf	-0.0421423	0.010341	0.00004620701	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0490828	0.0120475	0.00004643653	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0489029	0.0120099	0.00004688307	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20269544	chr1:2025441	1	2025441	PRKCZ	Island	-0.0349295	0.00857835	0.00004689215	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09322616	chr1:2040400	1	2040400	PRKCZ	North shore	0.0335312	0.00823549	0.00004694669	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	0.0016	None	0.000047	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEFF1 protein levels (SeqId = 15641-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEFF1 protein levels (SeqId = 15641-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tomoregulin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.571	0.14	0.000047	None	Gadd-DA_tmeff1_protein_levels__seqid___15641-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ROCK2 protein levels (SeqId = 13654-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ROCK2 protein levels (SeqId = 13654-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho-associated protein kinase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_rock2_protein_levels__seqid___13654-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GRB14 protein levels (SeqId = 13628-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRB14 protein levels (SeqId = 13628-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Growth factor receptor-bound protein 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_grb14_protein_levels__seqid___13628-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UFM1 protein levels (SeqId = 3836-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UFM1 protein levels (SeqId = 3836-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-fold modifier 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_ufm1_protein_levels__seqid___3836-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM52B protein levels (SeqId = 9778-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM52B protein levels (SeqId = 9778-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 52B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_tmem52b_protein_levels__seqid___9778-45__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NUDT16L1 protein levels (SeqId = 12497-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NUDT16L1 protein levels (SeqId = 12497-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tudor-interacting repair regulator protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_nudt16l1_protein_levels__seqid___12497-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AHSA1 protein levels (SeqId = 11633-89)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AHSA1 protein levels (SeqId = 11633-89)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Activator of 90 kDa heat shock protein ATPase homolog 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_ahsa1_protein_levels__seqid___11633-89__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLCA2 protein levels (SeqId = 8950-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLCA2 protein levels (SeqId = 8950-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-activated chloride channel regulator 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_clca2_protein_levels__seqid___8950-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PIP4K2A protein levels (SeqId = 12697-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PIP4K2A protein levels (SeqId = 12697-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000047	None	Gadd-DA_pip4k2a_protein_levels__seqid___12697-30__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0374843	0.00920858	0.00004714017	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26059839	chr1:1988681	1	1988681	PRKCZ	North shelf	0.0335842	0.00825191	0.00004728742	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	0.0335668	0.00825192	0.00004771722	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06717814	chr1:2038593	1	2038593	PRKCZ	Island	0.163169	0.0401229	0.00004788915	None	39706196_Hannah-M.-Smith_bmi_discovery
Kazmi N	PACE	31230546	2019-06-24	Hypertensive disorders of pregnancy	MONDO_0024664, EFO_0000537, EFO_0000668	Meta analysis adjusted model	Table S2	DNA methylation	Hypertensive disorders of pregnancy	Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	5242	10	Infants	Both	Unclear	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	0.005	0.0012	0.000048	None	31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	NRG4 protein levels (SeqId = 14139-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRG4 protein levels (SeqId = 14139-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pro-neuregulin-4, membrane-bound isoform	774	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.59	0.144	0.000048	None	Gadd-DA_nrg4_protein_levels__seqid___14139-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FANCL protein levels (SeqId = 10063-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FANCL protein levels (SeqId = 10063-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase FANCL	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_fancl_protein_levels__seqid___10063-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AGR2 protein levels (SeqId = 4959-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AGR2 protein levels (SeqId = 4959-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anterior gradient protein 2 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_agr2_protein_levels__seqid___4959-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GP6 protein levels (SeqId = 3194-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GP6 protein levels (SeqId = 3194-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet glycoprotein VI	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_gp6_protein_levels__seqid___3194-36__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFSF14 protein levels (SeqId = 5988-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFSF14 protein levels (SeqId = 5988-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor ligand superfamily member 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.571	0.14	0.000048	None	Gadd-DA_tnfsf14_protein_levels__seqid___5988-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL23R protein levels (SeqId = 5088-175)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL23R protein levels (SeqId = 5088-175)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-23 receptor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_il23r_protein_levels__seqid___5088-175__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AIFM1 protein levels (SeqId = 9522-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AIFM1 protein levels (SeqId = 9522-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apoptosis-inducing factor 1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_aifm1_protein_levels__seqid___9522-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	P2RX6 protein levels (SeqId = 7233-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	P2RX6 protein levels (SeqId = 7233-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: P2X purinoceptor 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000048	None	Gadd-DA_p2rx6_protein_levels__seqid___7233-73__somascan_protein_measurement
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg19803229	chr1:2005320	1	2005320	PRKCZ	Island	0.017	0.004	0.000048	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0525158	0.0129206	0.00004838591	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.0489331	0.0120416	0.00004855668	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22626579	chr1:2038628	1	2038628	PRKCZ	Island	-0.0341549	0.00840636	0.00004870064	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0373525	0.00919614	0.00004895851	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	IFI16 protein levels (SeqId = 12893-159)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFI16 protein levels (SeqId = 12893-159)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gamma-interferon-inducible protein 16	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_ifi16_protein_levels__seqid___12893-159__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MDK protein levels (SeqId = 2911-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDK protein levels (SeqId = 2911-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Midkine	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_mdk_protein_levels__seqid___2911-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C1QBP protein levels (SeqId = 4967-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1QBP protein levels (SeqId = 4967-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement component 1 Q subcomponent-binding protein, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_c1qbp_protein_levels__seqid___4967-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	INPP5B protein levels (SeqId = 12641-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	INPP5B protein levels (SeqId = 12641-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Type II inositol 1,4,5-trisphosphate 5-phosphatase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_inpp5b_protein_levels__seqid___12641-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RXFP1 protein levels (SeqId = 14135-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RXFP1 protein levels (SeqId = 14135-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Relaxin receptor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_rxfp1_protein_levels__seqid___14135-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FGL2 protein levels (SeqId = 19635-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGL2 protein levels (SeqId = 19635-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroleukin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_fgl2_protein_levels__seqid___19635-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2V2 protein levels (SeqId = 18165-181)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2V2 protein levels (SeqId = 18165-181)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 variant 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_ube2v2_protein_levels__seqid___18165-181__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKAP7 protein levels (SeqId = 18399-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKAP7 protein levels (SeqId = 18399-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: A-kinase anchor protein 7 isoforms alpha and beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_akap7_protein_levels__seqid___18399-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MYCT1 protein levels (SeqId = 13541-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MYCT1 protein levels (SeqId = 13541-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myc target protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_myct1_protein_levels__seqid___13541-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA0319L protein levels (SeqId = 13698-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA0319L protein levels (SeqId = 13698-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dyslexia-associated protein KIAA0319-like protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000049	None	Gadd-DA_kiaa0319l_protein_levels__seqid___13698-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	-0.0335094	0.00825193	0.00004915991	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0334922	0.00825194	0.00004960025	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0354132	0.00872534	0.00004961072	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0334796	0.00825194	0.00004992745	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	-0.0334772	0.00825194	0.00004998973	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MRC1 protein levels (SeqId = 2637-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRC1 protein levels (SeqId = 2637-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage mannose receptor 1	774	1	Adults (18-65 years)	Both	European	cg02912476	chr1:2035087	1	2035087	PRKCZ	North shelf	-0.68	0.167	0.00005	None	Gadd-DA_mrc1_protein_levels__seqid___2637-77__somascan_protein_measurement
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	None	None	0.00005	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	FEV protein levels (SeqId = 12740-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FEV protein levels (SeqId = 12740-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FEV	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.00005	None	Gadd-DA_fev_protein_levels__seqid___12740-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	S100A5 protein levels (SeqId = 15303-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	S100A5 protein levels (SeqId = 15303-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein S100-A5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.00005	None	Gadd-DA_s100a5_protein_levels__seqid___15303-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADAMTS4 protein levels (SeqId = 2809-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADAMTS4 protein levels (SeqId = 2809-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: A disintegrin and metalloproteinase with thrombospondin motifs 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.00005	None	Gadd-DA_adamts4_protein_levels__seqid___2809-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GSTT2B protein levels (SeqId = 11273-176)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSTT2B protein levels (SeqId = 11273-176)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione S-transferase theta-2B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.00005	None	Gadd-DA_gstt2b_protein_levels__seqid___11273-176__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLPP protein levels (SeqId = 17196-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLPP protein levels (SeqId = 17196-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ATP-dependent Clp protease proteolytic subunit, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.569	0.14	0.00005	None	Gadd-DA_clpp_protein_levels__seqid___17196-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24578937	chr1:2090814	1	2090814	PRKCZ	Open sea	-0.0487186	0.0120096	0.00005004372	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0334743	0.00825194	0.00005006435	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0673884	0.0166124	0.00005007021	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	0.0334649	0.00825195	0.00005030854	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13072890	chr1:2038377	1	2038377	PRKCZ	North shore	-0.0334599	0.00825195	0.00005043822	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.033458	0.00825195	0.00005048936	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.0541035	0.0133478	0.00005074567	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.0334387	0.00825195	0.0000509955	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC11 protein levels (SeqId = 8913-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC11 protein levels (SeqId = 8913-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 11	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000051	None	Gadd-DA_siglec11_protein_levels__seqid___8913-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPBP protein levels (SeqId = 2790-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPBP protein levels (SeqId = 2790-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet basic protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000051	None	Gadd-DA_ppbp_protein_levels__seqid___2790-54__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNRNPF protein levels (SeqId = 9764-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNRNPF protein levels (SeqId = 9764-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heterogeneous nuclear ribonucleoprotein F	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000051	None	Gadd-DA_hnrnpf_protein_levels__seqid___9764-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0334311	0.00825196	0.00005119736	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.033421	0.00825196	0.00005146495	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0450388	0.0111213	0.00005152853	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.20026	0.049456	0.00005160461	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0354991	0.00876816	0.00005178061	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07896009	chr1:2107669	1	2107669	PRKCZ	Open sea	0.0014	None	0.000052	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.09	0.0222	0.000052	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	RND3 protein levels (SeqId = 15439-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RND3 protein levels (SeqId = 15439-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rho-related GTP-binding protein RhoE	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000052	None	Gadd-DA_rnd3_protein_levels__seqid___15439-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TOR1AIP2 protein levels (SeqId = 10553-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TOR1AIP2 protein levels (SeqId = 10553-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Torsin-1A-interacting protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000052	None	Gadd-DA_tor1aip2_protein_levels__seqid___10553-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RFXAP protein levels (SeqId = 12726-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RFXAP protein levels (SeqId = 12726-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulatory factor X-associated protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000052	None	Gadd-DA_rfxap_protein_levels__seqid___12726-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HINT1 protein levels (SeqId = 5900-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HINT1 protein levels (SeqId = 5900-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histidine triad nucleotide-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000052	None	Gadd-DA_hint1_protein_levels__seqid___5900-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PALM protein levels (SeqId = 18306-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PALM protein levels (SeqId = 18306-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Paralemmin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000052	None	Gadd-DA_palm_protein_levels__seqid___18306-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	0.033398	0.00825197	0.00005208226	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00145954	chr1:2076496	1	2076496	PRKCZ	Open sea	0.0332029	0.00820416	0.00005212688	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.868015	0.2146	0.0000524	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.0333855	0.00825197	0.00005241994	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	0.191357	0.0473111	0.00005263061	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	0.180567	0.0446469	0.00005268925	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.0425192	0.0105145	0.00005284301	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05753589	chr1:2064765	1	2064765	PRKCZ	Island	0.033369	0.00825197	0.00005286994	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15767676	chr1:2115675	1	2115675	PRKCZ	North shore	0.0333687	0.00825197	0.00005287678	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.117395	0.0290366	0.00005298891	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Former vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	285	1	Adults	Both	European	cg17025688	chr1:2107410	1	2107410	PRKCZ	Open sea	-0.0099	0.00241	0.000053	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__former_vs_current_smokers
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRC74A protein levels (SeqId = 8389-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRC74A protein levels (SeqId = 8389-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat-containing protein 74A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000053	None	Gadd-DA_lrrc74a_protein_levels__seqid___8389-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SH3BGRL2 protein levels (SeqId = 19113-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SH3BGRL2 protein levels (SeqId = 19113-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SH3 domain-binding glutamic acid-rich-like protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000053	None	Gadd-DA_sh3bgrl2_protein_levels__seqid___19113-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GUK1 protein levels (SeqId = 17325-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GUK1 protein levels (SeqId = 17325-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanylate kinase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000053	None	Gadd-DA_guk1_protein_levels__seqid___17325-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	0.0333611	0.00825198	0.00005308668	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-0.00085758	0.00021131	0.0000531	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07131604	chr1:2099495	1	2099495	PRKCZ	Open sea	0.0333569	0.00825198	0.00005320124	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00359465	chr1:2004346	1	2004346	PRKCZ	North shore	0.191063	0.0472743	0.00005332122	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0333498	0.00825198	0.00005339581	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	0.0333456	0.00825198	0.00005351234	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0333365	0.00825198	0.00005376593	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Panni T	-	26731791	2016-07-01	Air pollution exposure	EFO_0008255	28-day trailing average particle matter concentration	Additional file 1	DNA methylation	Air pollution exposure	Age, sex, smoking, income, alcohol consumption, body mass index, cell counts and technical covariates	Beta values	mug/m3	Illumina HumanMethylation450	Whole blood	Regression coefficients per 10-muy/m3 increase in paricle matter polution	2956	3	62.2	Both	European	cg20975074	chr1:2066430	1	2066430	PRKCZ	Island	0.00561	0.001389	0.0000538	-	26731791_air_pollution_exposure_28day_trailing_average_particle_matter_concentration
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0488034	0.0120816	0.00005384226	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	None	None	0.000054	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0055	0.0014	0.000054	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP3 protein levels (SeqId = 18383-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP3 protein levels (SeqId = 18383-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000054	None	Gadd-DA_fkbp3_protein_levels__seqid___18383-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2L3 protein levels (SeqId = 3874-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2L3 protein levels (SeqId = 3874-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 L3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000054	None	Gadd-DA_ube2l3_protein_levels__seqid___3874-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TRAT1 protein levels (SeqId = 7224-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRAT1 protein levels (SeqId = 7224-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell receptor-associated transmembrane adapter 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000054	None	Gadd-DA_trat1_protein_levels__seqid___7224-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STUB1 protein levels (SeqId = 11350-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STUB1 protein levels (SeqId = 11350-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase CHIP	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000054	None	Gadd-DA_stub1_protein_levels__seqid___11350-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNRF3 protein levels (SeqId = 10390-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNRF3 protein levels (SeqId = 10390-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase ZNRF3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000054	None	Gadd-DA_znrf3_protein_levels__seqid___10390-21__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04100007	chr1:2075739	1	2075739	PRKCZ	Open sea	0.144058	0.0356792	0.00005423849	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	0.128453	0.0318199	0.00005440344	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	-0.033313	0.00825199	0.00005442181	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0357671	0.00886016	0.00005445137	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02481000	chr1:2082349	1	2082349	PRKCZ	Island	-0.0333112	0.00825199	0.00005447193	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.0463372	0.0114794	0.00005451578	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	0.033306	0.00825199	0.00005461764	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	0.151925	0.0376505	0.00005479636	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04315214	chr1:2043799	1	2043799	PRKCZ	North shelf	0.033299	0.00825199	0.00005481638	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	0.0332953	0.00825199	0.00005492241	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC11 protein levels (SeqId = 9783-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC11 protein levels (SeqId = 9783-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily C member 11	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000055	None	Gadd-DA_dnajc11_protein_levels__seqid___9783-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAN1B1 protein levels (SeqId = 7071-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAN1B1 protein levels (SeqId = 7071-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000055	None	Gadd-DA_man1b1_protein_levels__seqid___7071-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TRABD protein levels (SeqId = 11262-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRABD protein levels (SeqId = 11262-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: TraB domain-containing protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000055	None	Gadd-DA_trabd_protein_levels__seqid___11262-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR1A1 protein levels (SeqId = 4192-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR1A1 protein levels (SeqId = 4192-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aldo-keto reductase family 1 member A1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000055	None	Gadd-DA_akr1a1_protein_levels__seqid___4192-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPBP protein levels (SeqId = 17165-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPBP protein levels (SeqId = 17165-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet basic protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000055	None	Gadd-DA_ppbp_protein_levels__seqid___17165-1__somascan_protein_measurement
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg20151494	chr1:2047581	1	2047581	PRKCZ	South shore	0.0008535	0.00021075	0.000055	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08732456	chr1:2020870	1	2020870	PRKCZ	Open sea	-0.115112	0.028538	0.00005515884	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0332823	0.008252	0.00005529248	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	0.181917	0.0451077	0.00005531797	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0342078	0.00848513	0.00005570048	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.0332596	0.008252	0.00005594145	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Battram T	GEO	26635906	2020-09-15	Oral or pharyngeal squamous cell carcinoma	EFO_1001965, EFO_0000199	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE70977	None	DNA methylation	Oral or pharyngeal squamous cell carcinoma	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Saliva	None	223	1	Adults	Both	Unclear	cg01970427	chr1:2006896	1	2006896	PRKCZ	South shore	-0.00393	0.00096	0.000056	None	26635906_Battram-T_oral_or_pharyngeal_squamous_cell_carcinoma_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse70977
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	-0.0078	0.0019	0.000056	None	33450751_Mulder-RH_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SYT5 protein levels (SeqId = 9099-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYT5 protein levels (SeqId = 9099-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synaptotagmin-5	774	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.58	0.144	0.000056	None	Gadd-DA_syt5_protein_levels__seqid___9099-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MDH1 protein levels (SeqId = 3853-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDH1 protein levels (SeqId = 3853-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Malate dehydrogenase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000056	None	Gadd-DA_mdh1_protein_levels__seqid___3853-56__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADM protein levels (SeqId = 14115-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADM protein levels (SeqId = 14115-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADM	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.57	0.14	0.000056	None	Gadd-DA_adm_protein_levels__seqid___14115-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LAMTOR3 protein levels (SeqId = 12490-92)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAMTOR3 protein levels (SeqId = 12490-92)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ragulator complex protein LAMTOR3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000056	None	Gadd-DA_lamtor3_protein_levels__seqid___12490-92__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25726135	chr1:2088708	1	2088708	PRKCZ	Open sea	-0.0004	0.000099	0.000056	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	0.0332537	0.00825201	0.00005611191	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09261593	chr1:2058612	1	2058612	PRKCZ	Open sea	0.0332508	0.00825201	0.0000561961	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-0.0332485	0.00825201	0.00005626291	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24445388	chr1:2084391	1	2084391	PRKCZ	South shore	-0.0332428	0.00825201	0.0000564293	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.0332379	0.00825201	0.00005657176	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	0.0332372	0.00825201	0.00005659295	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	0.0342228	0.00849765	0.00005670001	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0332236	0.00825201	0.00005699044	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EDA protein levels (SeqId = 2826-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EDA protein levels (SeqId = 2826-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectodysplasin-A	774	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	-0.76	0.19	0.000057	None	Gadd-DA_eda_protein_levels__seqid___2826-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CTBP1 protein levels (SeqId = 11217-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTBP1 protein levels (SeqId = 11217-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-terminal-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000057	None	Gadd-DA_ctbp1_protein_levels__seqid___11217-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FLRT1 protein levels (SeqId = 4547-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FLRT1 protein levels (SeqId = 4547-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat transmembrane protein FLRT1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000057	None	Gadd-DA_flrt1_protein_levels__seqid___4547-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MSRB2 protein levels (SeqId = 16877-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MSRB2 protein levels (SeqId = 16877-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Methionine-R-sulfoxide reductase B2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.565	0.14	0.000057	None	Gadd-DA_msrb2_protein_levels__seqid___16877-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGAL protein levels (SeqId = 11617-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGAL protein levels (SeqId = 11617-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin alpha-L	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000057	None	Gadd-DA_itgal_protein_levels__seqid___11617-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	0.0332206	0.00825201	0.00005707914	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg24054683	chr1:2085751	1	2085751	PRKCZ	South shelf	-0.111935	0.0278	0.0000572	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00312809	chr1:2028213	1	2028213	PRKCZ	South shore	0.0332125	0.00825202	0.0000573175	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	-0.0613658	0.0152472	0.0000573309	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0421864	0.0104822	0.00005736327	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25973481	chr1:2075344	1	2075344	PRKCZ	Open sea	0.033206	0.00825202	0.00005750754	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	2,4-Dichlorophenoxyacetic acid (2,4-D)	CHEBI_28854	discovery	10.5281/zenodo.5156585	DNA methylation	2,4-Dichlorophenoxyacetic acid (2,4-D)	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	466	1	Adults	Males	European	cg04105350	chr1:2111868	1	2111868	PRKCZ	Open sea	-0.00288	0.00072	0.000058	None	34516295_Hoang_2_4-dichlorophenoxyacetic_acid__2_4-d__discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04771433	chr1:2064216	1	2064216	PRKCZ	North shore	-0.00069	0.00017	0.000058	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG2 protein levels (SeqId = 7258-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG2 protein levels (SeqId = 7258-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone marrow proteoglycan	774	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-1.08	0.269	0.000058	None	Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SCO1 protein levels (SeqId = 7853-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCO1 protein levels (SeqId = 7853-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein SCO1 homolog, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.563	0.14	0.000058	None	Gadd-DA_sco1_protein_levels__seqid___7853-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMA1 protein levels (SeqId = 3859-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMA1 protein levels (SeqId = 3859-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit alpha type-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000058	None	Gadd-DA_psma1_protein_levels__seqid___3859-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	QDPR protein levels (SeqId = 11257-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	QDPR protein levels (SeqId = 11257-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dihydropteridine reductase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000058	None	Gadd-DA_qdpr_protein_levels__seqid___11257-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SEZ6L2 protein levels (SeqId = 3867-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEZ6L2 protein levels (SeqId = 3867-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Seizure 6-like protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000058	None	Gadd-DA_sez6l2_protein_levels__seqid___3867-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDC25B protein levels (SeqId = 12427-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDC25B protein levels (SeqId = 12427-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: M-phase inducer phosphatase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000058	None	Gadd-DA_cdc25b_protein_levels__seqid___12427-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDC2 protein levels (SeqId = 3422-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDC2 protein levels (SeqId = 3422-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase 1|G2/mitotic-specific cyclin-B1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.562	0.14	0.000058	None	Gadd-DA_cdc2_protein_levels__seqid___3422-4__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20328379	chr1:2048946	1	2048946	PRKCZ	South shelf	0.01033	0.00251	0.000058	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0331812	0.00825203	0.00005824604	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0391936	0.00974771	0.00005829041	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0391951	0.00975017	0.00005850543	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01449266	chr1:2109999	1	2109999	PRKCZ	Open sea	0.0331624	0.00825203	0.00005881211	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08651178	chr1:2035295	1	2035295	PRKCZ	North shelf	0.18463	0.0459467	0.00005885251	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0366136	0.00911243	0.00005899125	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Concentration of IDL particles	EFO_0008595	None	None	DNA methylation	Concentration of IDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	None	None	0.000059	None	Battram-T_concentration_of_idl_particles
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg16048006	chr1:2065263	1	2065263	PRKCZ	North shore	-0.098	0.0243	0.000059	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	ANXA4 protein levels (SeqId = 17164-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANXA4 protein levels (SeqId = 17164-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Annexin A4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_anxa4_protein_levels__seqid___17164-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCL5 protein levels (SeqId = 5480-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCL5 protein levels (SeqId = 5480-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-C motif chemokine 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_ccl5_protein_levels__seqid___5480-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RMI1 protein levels (SeqId = 13926-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RMI1 protein levels (SeqId = 13926-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RecQ-mediated genome instability protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_rmi1_protein_levels__seqid___13926-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAPB protein levels (SeqId = 12655-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAPB protein levels (SeqId = 12655-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-soluble NSF attachment protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_napb_protein_levels__seqid___12655-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM162B protein levels (SeqId = 11163-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM162B protein levels (SeqId = 11163-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FAM162B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_fam162b_protein_levels__seqid___11163-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AGO1 protein levels (SeqId = 15312-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AGO1 protein levels (SeqId = 15312-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein argonaute-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_ago1_protein_levels__seqid___15312-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDXP protein levels (SeqId = 3897-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDXP protein levels (SeqId = 3897-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyridoxal phosphate phosphatase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000059	None	Gadd-DA_pdxp_protein_levels__seqid___3897-61__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	0.00024	None	0.000059	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	0.0331543	0.00825203	0.00005905824	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	0.033149	0.00825203	0.00005921904	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0330431	0.0082302	0.00005977817	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0331295	0.00825204	0.00005981591	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.033125	0.00825204	0.00005995543	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KIF16B protein levels (SeqId = 11672-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIF16B protein levels (SeqId = 11672-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kinesin-like protein KIF16B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00006	None	Gadd-DA_kif16b_protein_levels__seqid___11672-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUSD1 protein levels (SeqId = 9582-93)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUSD1 protein levels (SeqId = 9582-93)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sushi domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.563	0.14	0.00006	None	Gadd-DA_susd1_protein_levels__seqid___9582-93__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SDF2L1 protein levels (SeqId = 6990-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDF2L1 protein levels (SeqId = 6990-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 2-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00006	None	Gadd-DA_sdf2l1_protein_levels__seqid___6990-44__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIR3DL3 protein levels (SeqId = 7944-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIR3DL3 protein levels (SeqId = 7944-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Killer cell immunoglobulin-like receptor 3DL3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00006	None	Gadd-DA_kir3dl3_protein_levels__seqid___7944-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PURA protein levels (SeqId = 12537-88)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PURA protein levels (SeqId = 12537-88)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcriptional activator protein Pur-alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00006	None	Gadd-DA_pura_protein_levels__seqid___12537-88__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP4 protein levels (SeqId = 17722-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP4 protein levels (SeqId = 17722-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00006	None	Gadd-DA_fkbp4_protein_levels__seqid___17722-5__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.217096	0.0540877	0.00006000785	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg02293396	chr1:2041228	1	2041228	PRKCZ	Island	-0.215945	0.0538	0.0000606	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0375807	0.00936803	0.00006060986	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Total lipids in IDL	EFO_0004529	None	None	DNA methylation	Total lipids in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	0.42	0.104	0.000061	None	Battram-T_total_lipids_in_idl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11835265	chr1:2011913	1	2011913	PRKCZ	Open sea	-0.0079	0.002	0.000061	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PARK2 protein levels (SeqId = 13013-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PARK2 protein levels (SeqId = 13013-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase parkin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000061	None	Gadd-DA_park2_protein_levels__seqid___13013-41__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRPAP1 protein levels (SeqId = 3640-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRPAP1 protein levels (SeqId = 3640-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-2-macroglobulin receptor-associated protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.139	0.000061	None	Gadd-DA_lrpap1_protein_levels__seqid___3640-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RAB13 protein levels (SeqId = 19282-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAB13 protein levels (SeqId = 19282-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein Rab-13	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000061	None	Gadd-DA_rab13_protein_levels__seqid___19282-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HS3ST5 protein levels (SeqId = 10731-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HS3ST5 protein levels (SeqId = 10731-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000061	None	Gadd-DA_hs3st5_protein_levels__seqid___10731-10__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg25444428	chr1:2004977	1	2004977	PRKCZ	North shore	-0.2	0.0505	0.000061	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22626579	chr1:2038628	1	2038628	PRKCZ	Island	-0.0337089	0.00840628	0.0000610274	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0347782	0.0086756	0.00006134795	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0330663	0.00825206	0.00006178804	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids in IDL	EFO_0004639	None	None	DNA methylation	Phospholipids in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	1.63	0.4	0.000062	None	Battram-T_phospholipids_in_idl
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Colorectal Cancer (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Colorectal Cancer (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg12391964	chr1:1986275	1	1986275	PRKCZ	South shelf	0.028	0.00707	0.000062	None	Robert-F-Hillary_Prevalent_Colorectal_Cancer_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SNX1 protein levels (SeqId = 6955-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNX1 protein levels (SeqId = 6955-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sorting nexin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000062	None	Gadd-DA_snx1_protein_levels__seqid___6955-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17740743	chr1:1986220	1	1986220	PRKCZ	South shelf	0.0353209	0.00881708	0.00006207225	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.0341871	0.00853464	0.00006214377	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.0340942	0.00851187	0.00006219508	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	-0.190471	0.0475625	0.00006235792	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0347571	0.00867971	0.00006247813	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg09180820	chr1:2113911	1	2113911	PRKCZ	North shelf	-0.086158	0.0215	0.0000626	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08659047	chr1:2022951	1	2022951	PRKCZ	North shelf	-0.0330387	0.00825206	0.00006267015	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol in IDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	0.63	0.16	0.000063	None	Battram-T_total_cholesterol_in_idl
Gadd DA	Generation Scotland	35945220	31/07/2022	LDLR protein levels (SeqId = 13129-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LDLR protein levels (SeqId = 13129-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low-density lipoprotein receptor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.559	0.14	0.000063	None	Gadd-DA_ldlr_protein_levels__seqid___13129-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PROK1 protein levels (SeqId = 2247-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PROK1 protein levels (SeqId = 2247-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prokineticin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_prok1_protein_levels__seqid___2247-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NMRAL1 protein levels (SeqId = 13988-67)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMRAL1 protein levels (SeqId = 13988-67)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NmrA-like family domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_nmral1_protein_levels__seqid___13988-67__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STOM protein levels (SeqId = 8261-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STOM protein levels (SeqId = 8261-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Erythrocyte band 7 integral membrane protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.561	0.14	0.000063	None	Gadd-DA_stom_protein_levels__seqid___8261-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MDH2 protein levels (SeqId = 15534-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDH2 protein levels (SeqId = 15534-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Malate dehydrogenase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_mdh2_protein_levels__seqid___15534-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STK17B protein levels (SeqId = 8399-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STK17B protein levels (SeqId = 8399-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase 17B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_stk17b_protein_levels__seqid___8399-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CYTH2 protein levels (SeqId = 12533-135)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CYTH2 protein levels (SeqId = 12533-135)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytohesin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_cyth2_protein_levels__seqid___12533-135__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2I protein levels (SeqId = 2877-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2I protein levels (SeqId = 2877-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SUMO-conjugating enzyme UBC9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000063	None	Gadd-DA_ube2i_protein_levels__seqid___2877-3__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.157109	0.0392577	0.0000630729	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0330203	0.00825207	0.00006326335	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	0.0338062	0.00844951	0.00006339412	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.011	0.003	0.0000636	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05351942	chr1:2018107	1	2018107	PRKCZ	Open sea	-0.0330028	0.00825207	0.00006383095	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PLBD2 protein levels (SeqId = 6536-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLBD2 protein levels (SeqId = 6536-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Putative phospholipase B-like 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_plbd2_protein_levels__seqid___6536-54__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C16orf54 protein levels (SeqId = 12394-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C16orf54 protein levels (SeqId = 12394-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein C16orf54	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_c16orf54_protein_levels__seqid___12394-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPBP protein levels (SeqId = 4544-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPBP protein levels (SeqId = 4544-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet basic protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_ppbp_protein_levels__seqid___4544-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NRAC protein levels (SeqId = 13464-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRAC protein levels (SeqId = 13464-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nutritionally-regulated adipose and cardiac enriched protein homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_nrac_protein_levels__seqid___13464-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CASP10 protein levels (SeqId = 5340-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CASP10 protein levels (SeqId = 5340-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Caspase-10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_casp10_protein_levels__seqid___5340-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPM1L protein levels (SeqId = 7187-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPM1L protein levels (SeqId = 7187-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein phosphatase 1L	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000064	None	Gadd-DA_ppm1l_protein_levels__seqid___7187-3__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24447775	chr1:1992534	1	1992534	PRKCZ	South shore	0.0043	None	0.000064	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	0.0108	0.0027	0.000064	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	CST6 protein levels (SeqId = 14711-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CST6 protein levels (SeqId = 14711-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cystatin-M	774	1	Adults (18-65 years)	Both	European	cg09433064	chr1:2082528	1	2082528	PRKCZ	Island	0.9	0.226	0.000064	None	Gadd-DA_cst6_protein_levels__seqid___14711-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	-0.0329916	0.00825208	0.00006419937	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0329761	0.00825208	0.00006470934	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	0.0508246	0.0127187	0.00006472259	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	0.0352773	0.00883009	0.00006497656	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SEPHS1 protein levels (SeqId = 14083-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEPHS1 protein levels (SeqId = 14083-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Selenide, water dikinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000065	None	Gadd-DA_sephs1_protein_levels__seqid___14083-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SYNE2 protein levels (SeqId = 9789-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYNE2 protein levels (SeqId = 9789-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nesprin-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000065	None	Gadd-DA_syne2_protein_levels__seqid___9789-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AFP protein levels (SeqId = 5792-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AFP protein levels (SeqId = 5792-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-fetoprotein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000065	None	Gadd-DA_afp_protein_levels__seqid___5792-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PLEK protein levels (SeqId = 7875-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLEK protein levels (SeqId = 7875-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pleckstrin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000065	None	Gadd-DA_plek_protein_levels__seqid___7875-86__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0329465	0.00825209	0.00006569923	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03580279	chr1:2015974	1	2015974	PRKCZ	Open sea	0.00906	0.00222	0.000066	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	ARIES	None	2020-08-20	Cholesterol esters in IDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	0.88	0.22	0.000066	None	Battram-T_cholesterol_esters_in_idl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18269141	chr1:2063966	1	2063966	PRKCZ	Island	0.0021	None	0.000066	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NAA10 protein levels (SeqId = 17854-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAA10 protein levels (SeqId = 17854-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-alpha-acetyltransferase 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.559	0.14	0.000066	None	Gadd-DA_naa10_protein_levels__seqid___17854-33__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25060388	chr1:2096722	1	2096722	PRKCZ	Open sea	0.109318	0.0273905	0.00006603891	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12828504	chr1:2059991	1	2059991	PRKCZ	North shelf	-0.0382217	0.00957853	0.00006629678	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	-0.0481207	0.0120651	0.00006683576	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	OPALIN protein levels (SeqId = 7736-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OPALIN protein levels (SeqId = 7736-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Opalin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000067	None	Gadd-DA_opalin_protein_levels__seqid___7736-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDRG1 protein levels (SeqId = 12593-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDRG1 protein levels (SeqId = 12593-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: p53 and DNA damage-regulated protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000067	None	Gadd-DA_pdrg1_protein_levels__seqid___12593-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FGF16 protein levels (SeqId = 4393-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGF16 protein levels (SeqId = 4393-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroblast growth factor 16	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000067	None	Gadd-DA_fgf16_protein_levels__seqid___4393-3__somascan_protein_measurement
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg27264462	chr1:2106365	1	2106365	PRKCZ	Open sea	-0.0073	0.0018	0.000067	None	33564054_Kashima-K_gestational_age
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	0.011	0.003	0.0000673	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.199366	0.05	0.0000676	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.037606	0.00943593	0.00006768976	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0792893	0.019898	0.00006786932	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Battram T	GEO	26459776	2020-09-15	Graves' disease	EFO_0004237	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE71955	None	DNA methylation	Graves' disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	T cells	None	135	1	Adults	Both	Unclear	cg10761639	chr1:2023794	1	2023794	PRKCZ	North shore	0.0633	0.0153	0.000068	None	26459776_Battram-T_graves__disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse71955
Gadd DA	Generation Scotland	35945220	31/07/2022	FEN1 protein levels (SeqId = 12577-100)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FEN1 protein levels (SeqId = 12577-100)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Flap endonuclease 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000068	None	Gadd-DA_fen1_protein_levels__seqid___12577-100__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SHC4 protein levels (SeqId = 11692-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHC4 protein levels (SeqId = 11692-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SHC-transforming protein 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000068	None	Gadd-DA_shc4_protein_levels__seqid___11692-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDH15 protein levels (SeqId = 5410-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDH15 protein levels (SeqId = 5410-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cadherin-15	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000068	None	Gadd-DA_cdh15_protein_levels__seqid___5410-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ELAVL1 protein levels (SeqId = 11592-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ELAVL1 protein levels (SeqId = 11592-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ELAV-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000068	None	Gadd-DA_elavl1_protein_levels__seqid___11592-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CTF1 protein levels (SeqId = 2889-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTF1 protein levels (SeqId = 2889-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cardiotrophin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000068	None	Gadd-DA_ctf1_protein_levels__seqid___2889-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0328782	0.00825211	0.00006802895	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Panni T	-	26731791	2016-07-01	Air pollution exposure	EFO_0008255	28-day trailing average particle matter concentration	Additional file 1	DNA methylation	Air pollution exposure	Age, sex, smoking, income, alcohol consumption, body mass index, cell counts and technical covariates	Beta values	mug/m3	Illumina HumanMethylation450	Whole blood	Regression coefficients per 10-muy/m3 increase in paricle matter polution	2956	3	62.2	Both	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	0.00385	0.000967	0.0000682	-	26731791_air_pollution_exposure_28day_trailing_average_particle_matter_concentration
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0328676	0.00825211	0.00006840016	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0549632	0.0138014	0.00006853939	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.0328545	0.00825211	0.00006885544	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LOXL3 protein levels (SeqId = 15427-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LOXL3 protein levels (SeqId = 15427-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysyl oxidase homolog 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_loxl3_protein_levels__seqid___15427-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	L3MBTL2 protein levels (SeqId = 12708-91)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	L3MBTL2 protein levels (SeqId = 12708-91)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lethal(3)malignant brain tumor-like protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_l3mbtl2_protein_levels__seqid___12708-91__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MLL2 protein levels (SeqId = 13623-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MLL2 protein levels (SeqId = 13623-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone-lysine N-methyltransferase 2D	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_mll2_protein_levels__seqid___13623-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PCBP1 protein levels (SeqId = 11458-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCBP1 protein levels (SeqId = 11458-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Poly(rC)-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_pcbp1_protein_levels__seqid___11458-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GALNT11 protein levels (SeqId = 8700-325)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GALNT11 protein levels (SeqId = 8700-325)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polypeptide N-acetylgalactosaminyltransferase 11	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_galnt11_protein_levels__seqid___8700-325__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HLA-DRB3 protein levels (SeqId = 6962-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HLA-DRB3 protein levels (SeqId = 6962-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: HLA class II histocompatibility antigen, DR beta 3 chain	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000069	None	Gadd-DA_hla-drb3_protein_levels__seqid___6962-5__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15502607	chr1:1990986	1	1990986	PRKCZ	Island	-0.177735	0.0446512	0.00006902894	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25444428	chr1:2004977	1	2004977	PRKCZ	North shore	-0.166861	0.0419317	0.00006937168	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg09144608	chr1:2098929	1	2098929	PRKCZ	Open sea	-0.181624	0.0457	0.0000696	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08108679	chr1:2003274	1	2003274	PRKCZ	North shore	-0.0328275	0.00825212	0.00006981038	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	-0.0346218	0.00870327	0.00006982521	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	-0.0328234	0.00825212	0.00006995819	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.034103	0.00857389	0.00006996481	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Prostate Cancer	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Prostate Cancer	Age, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	6084	1	Adults (18-65y)	Males	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	-0.028	0.00701	0.00007	None	Robert-F-Hillary_Incident_Prostate_Cancer_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	CTRB1 protein levels (SeqId = 5671-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTRB1 protein levels (SeqId = 5671-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chymotrypsinogen B	774	1	Adults (18-65 years)	Both	European	cg06717814	chr1:2038593	1	2038593	PRKCZ	Island	0.83	0.209	0.00007	None	Gadd-DA_ctrb1_protein_levels__seqid___5671-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NXT1 protein levels (SeqId = 9942-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NXT1 protein levels (SeqId = 9942-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NTF2-related export protein 1	774	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.57	0.144	0.00007	None	Gadd-DA_nxt1_protein_levels__seqid___9942-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2V1 protein levels (SeqId = 11626-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2V1 protein levels (SeqId = 11626-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 variant 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00007	None	Gadd-DA_ube2v1_protein_levels__seqid___11626-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMM protein levels (SeqId = 5704-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMM protein levels (SeqId = 5704-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme M	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00007	None	Gadd-DA_gzmm_protein_levels__seqid___5704-74__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HS3ST4 protein levels (SeqId = 19370-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HS3ST4 protein levels (SeqId = 19370-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00007	None	Gadd-DA_hs3st4_protein_levels__seqid___19370-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SULF2 protein levels (SeqId = 8305-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SULF2 protein levels (SeqId = 8305-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Extracellular sulfatase Sulf-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00007	None	Gadd-DA_sulf2_protein_levels__seqid___8305-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IFNL1 protein levels (SeqId = 4396-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFNL1 protein levels (SeqId = 4396-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon lambda-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.00007	None	Gadd-DA_ifnl1_protein_levels__seqid___4396-54__somascan_protein_measurement
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg20285026	chr1:1983774	1	1983774	PRKCZ	South shore	0.022	0.005	0.00007	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	0.855322	0.2152	0.0000703	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	0.0328103	0.00825213	0.0000704262	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0327992	0.00825213	0.00007082459	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02138098	chr1:2040968	1	2040968	PRKCZ	North shore	-0.00763	0.00188	0.000071	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	None	None	0.000071	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	HSPA6 protein levels (SeqId = 13672-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSPA6 protein levels (SeqId = 13672-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heat shock 70 kDa protein 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_hspa6_protein_levels__seqid___13672-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL6 protein levels (SeqId = 3495-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL6 protein levels (SeqId = 3495-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 6	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.552	0.139	0.000071	None	Gadd-DA_cxcl6_protein_levels__seqid___3495-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALKBH3 protein levels (SeqId = 18401-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALKBH3 protein levels (SeqId = 18401-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_alkbh3_protein_levels__seqid___18401-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DSC1 protein levels (SeqId = 10882-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSC1 protein levels (SeqId = 10882-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmocollin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_dsc1_protein_levels__seqid___10882-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GOSR1 protein levels (SeqId = 7805-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GOSR1 protein levels (SeqId = 7805-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Golgi SNAP receptor complex member 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_gosr1_protein_levels__seqid___7805-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPS6KA3 protein levels (SeqId = 3469-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPS6KA3 protein levels (SeqId = 3469-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosomal protein S6 kinase alpha-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_rps6ka3_protein_levels__seqid___3469-74__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C10orf105 protein levels (SeqId = 11220-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C10orf105 protein levels (SeqId = 11220-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C10orf105	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_c10orf105_protein_levels__seqid___11220-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAP2K1 protein levels (SeqId = 2864-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAP2K1 protein levels (SeqId = 2864-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_map2k1_protein_levels__seqid___2864-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKACA protein levels (SeqId = 3466-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKACA protein levels (SeqId = 3466-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: cAMP-dependent protein kinase catalytic subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000071	None	Gadd-DA_prkaca_protein_levels__seqid___3466-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01917640	chr1:2009349	1	2009349	PRKCZ	South shelf	-0.0327937	0.00825213	0.00007102479	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	0.0307272	0.00773418	0.00007133951	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0346464	0.00872238	0.00007157483	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.032772	0.00825214	0.00007181197	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0365106	0.0091949	0.00007198926	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04146995	chr1:2001651	1	2001651	PRKCZ	North shelf	0.034034	0.00857121	0.00007199402	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2E1 protein levels (SeqId = 14326-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2E1 protein levels (SeqId = 14326-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 E1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_ube2e1_protein_levels__seqid___14326-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MPP7 protein levels (SeqId = 12732-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MPP7 protein levels (SeqId = 12732-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAGUK p55 subfamily member 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_mpp7_protein_levels__seqid___12732-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CMA1 protein levels (SeqId = 3423-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CMA1 protein levels (SeqId = 3423-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chymase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_cma1_protein_levels__seqid___3423-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NCL protein levels (SeqId = 13655-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCL protein levels (SeqId = 13655-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nucleolin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_ncl_protein_levels__seqid___13655-34__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LYPLAL1 protein levels (SeqId = 12428-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LYPLAL1 protein levels (SeqId = 12428-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysophospholipase-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_lyplal1_protein_levels__seqid___12428-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMA3 protein levels (SeqId = 18926-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMA3 protein levels (SeqId = 18926-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit alpha type-3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000072	None	Gadd-DA_psma3_protein_levels__seqid___18926-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NTS protein levels (SeqId = 7857-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NTS protein levels (SeqId = 7857-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurotensin/neuromedin N	774	1	Adults (18-65 years)	Both	European	cg24042578	chr1:2066981	1	2066981	PRKCZ	South shore	-0.563	0.142	0.000072	None	Gadd-DA_nts_protein_levels__seqid___7857-22__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0313648	0.00789942	0.00007205936	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0327554	0.00825214	0.00007242109	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.100239	0.0252576	0.00007262128	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.0359244	0.00905418	0.00007291091	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in very large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	628	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	0.022	0.0055	0.000073	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_very_large_vldl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14778173	chr1:2103645	1	2103645	PRKCZ	Open sea	0.0042	None	0.000073	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	LDLRAP1 protein levels (SeqId = 18183-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LDLRAP1 protein levels (SeqId = 18183-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low density lipoprotein receptor adapter protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000073	None	Gadd-DA_ldlrap1_protein_levels__seqid___18183-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KCNE5 protein levels (SeqId = 8756-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KCNE5 protein levels (SeqId = 8756-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Potassium voltage-gated channel subfamily E regulatory beta subunit 5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000073	None	Gadd-DA_kcne5_protein_levels__seqid___8756-41__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP14 protein levels (SeqId = 9340-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP14 protein levels (SeqId = 9340-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peptidyl-prolyl cis-trans isomerase FKBP14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000073	None	Gadd-DA_fkbp14_protein_levels__seqid___9340-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDGFD protein levels (SeqId = 9341-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDGFD protein levels (SeqId = 9341-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet-derived growth factor D	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000073	None	Gadd-DA_pdgfd_protein_levels__seqid___9341-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPP3CA protein levels (SeqId = 4903-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPP3CA protein levels (SeqId = 4903-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcineurin subunit B type 1|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000073	None	Gadd-DA_ppp3ca_protein_levels__seqid___4903-72__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNF4A protein levels (SeqId = 10041-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNF4A protein levels (SeqId = 10041-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatocyte nuclear factor 4-alpha	774	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.64	0.161	0.000073	None	Gadd-DA_hnf4a_protein_levels__seqid___10041-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0327321	0.00825215	0.00007328457	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19870743	chr1:2097158	1	2097158	PRKCZ	Open sea	-0.0321957	0.00811827	0.00007348565	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.0364903	0.00920359	0.0000738105	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.042379	0.0106895	0.00007388829	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	MDM2 protein levels (SeqId = 13228-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDM2 protein levels (SeqId = 13228-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase Mdm2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_mdm2_protein_levels__seqid___13228-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HDHD2 protein levels (SeqId = 13472-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HDHD2 protein levels (SeqId = 13472-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Haloacid dehalogenase-like hydrolase domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_hdhd2_protein_levels__seqid___13472-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDYN protein levels (SeqId = 19638-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDYN protein levels (SeqId = 19638-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proenkephalin-B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000074	None	Gadd-DA_pdyn_protein_levels__seqid___19638-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITPKA protein levels (SeqId = 13473-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITPKA protein levels (SeqId = 13473-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inositol-trisphosphate 3-kinase A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_itpka_protein_levels__seqid___13473-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACYP2 protein levels (SeqId = 12812-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACYP2 protein levels (SeqId = 12812-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acylphosphatase-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000074	None	Gadd-DA_acyp2_protein_levels__seqid___12812-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK9 protein levels (SeqId = 15604-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK9 protein levels (SeqId = 15604-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_mapk9_protein_levels__seqid___15604-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARFGAP1 protein levels (SeqId = 11556-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARFGAP1 protein levels (SeqId = 11556-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor GTPase-activating protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_arfgap1_protein_levels__seqid___11556-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GP5 protein levels (SeqId = 7185-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GP5 protein levels (SeqId = 7185-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet glycoprotein V	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000074	None	Gadd-DA_gp5_protein_levels__seqid___7185-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CEL protein levels (SeqId = 9796-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CEL protein levels (SeqId = 9796-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bile salt-activated lipase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000074	None	Gadd-DA_cel_protein_levels__seqid___9796-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MADCAM1 protein levels (SeqId = 11258-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MADCAM1 protein levels (SeqId = 11258-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mucosal addressin cell adhesion molecule 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.556	0.14	0.000074	None	Gadd-DA_madcam1_protein_levels__seqid___11258-41__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06315149	chr1:2036398	1	2036398	PRKCZ	North shelf	0.0343979	0.00867792	0.00007410225	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.0373105	0.00941571	0.00007449622	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16644344	chr1:2100169	1	2100169	PRKCZ	Open sea	0.0326985	0.00825216	0.00007454442	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0374983	0.00946365	0.00007456813	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	-0.032696	0.00825216	0.00007464132	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	-0.158704	0.0400589	0.00007469386	None	39706196_Hannah-M.-Smith_bmi_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	HSPB1 protein levels (SeqId = 11103-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HSPB1 protein levels (SeqId = 11103-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heat shock protein beta-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.555	0.14	0.000075	None	Gadd-DA_hspb1_protein_levels__seqid___11103-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADAM17 protein levels (SeqId = 8959-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADAM17 protein levels (SeqId = 8959-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 17	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000075	None	Gadd-DA_adam17_protein_levels__seqid___8959-61__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NT5C protein levels (SeqId = 12560-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NT5C protein levels (SeqId = 12560-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 5'(3')-deoxyribonucleotidase, cytosolic type	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000075	None	Gadd-DA_nt5c_protein_levels__seqid___12560-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000075	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NIP7 protein levels (SeqId = 12564-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NIP7 protein levels (SeqId = 12564-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 60S ribosome subunit biogenesis protein NIP7 homolog	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000075	None	Gadd-DA_nip7_protein_levels__seqid___12564-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ASH2L protein levels (SeqId = 12832-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASH2L protein levels (SeqId = 12832-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Set1/Ash2 histone methyltransferase complex subunit ASH2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000075	None	Gadd-DA_ash2l_protein_levels__seqid___12832-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	0.0327916	0.00827922	0.00007507989	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0326838	0.00825216	0.00007510321	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0326817	0.00825216	0.00007518463	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0326717	0.00825216	0.00007556438	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12713909	chr1:2038940	1	2038940	PRKCZ	South shore	-0.0326658	0.00825217	0.0000757914	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10334053	chr1:2078117	1	2078117	PRKCZ	Open sea	-0.0326629	0.00825217	0.0000759028	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Robinson N	Avon Longitudinal study of Parents and Children (ALSPAC)	33436068	2021-01-12	rapid weight gain in first 12 months of life	EFO_0004566	Follow up.  Adjusted for age, sex, cell composition (reference based), batch effects (SVA)	ESM table 3	DNA methylation	rapid weight gain in first 12 months of life	age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	age 17	89	1	Children	Both	European	cg09180820	chr1:2113911	1	2113911	PRKCZ	North shelf	-0.03	0.007	0.000076	None	33436068_Robinson-N_rapid_weight_gain_in_first_12_months_of_life_follow_up___adjusted_for_age__sex__cell_composition__reference_based___batch_effects__sva_
Gadd DA	Generation Scotland	35945220	31/07/2022	OOSP2 protein levels (SeqId = 7106-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OOSP2 protein levels (SeqId = 7106-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oocyte-secreted protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000076	None	Gadd-DA_oosp2_protein_levels__seqid___7106-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF329 protein levels (SeqId = 12803-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF329 protein levels (SeqId = 12803-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 329	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000076	None	Gadd-DA_znf329_protein_levels__seqid___12803-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BOLA1 protein levels (SeqId = 15370-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BOLA1 protein levels (SeqId = 15370-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BolA-like protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000076	None	Gadd-DA_bola1_protein_levels__seqid___15370-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PGAM2 protein levels (SeqId = 15524-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGAM2 protein levels (SeqId = 15524-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate mutase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.555	0.14	0.000076	None	Gadd-DA_pgam2_protein_levels__seqid___15524-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC15 protein levels (SeqId = 7197-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC15 protein levels (SeqId = 7197-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily C member 15	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000076	None	Gadd-DA_dnajc15_protein_levels__seqid___7197-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DTD2 protein levels (SeqId = 18280-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DTD2 protein levels (SeqId = 18280-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: D-aminoacyl-tRNA deacylase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000076	None	Gadd-DA_dtd2_protein_levels__seqid___18280-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RDH16 protein levels (SeqId = 12881-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RDH16 protein levels (SeqId = 12881-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinol dehydrogenase 16	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.56	0.14	0.000076	None	Gadd-DA_rdh16_protein_levels__seqid___12881-17__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg11989056	chr1:2090849	1	2090849	PRKCZ	Open sea	0.153083	0.0386881	0.00007623306	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0326496	0.00825217	0.00007641856	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26930596	chr1:2082315	1	2082315	PRKCZ	Island	0.0781169	0.019749	0.00007674051	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0351637	0.0088901	0.00007677398	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.0326397	0.00825217	0.00007680123	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0578372	0.0146241	0.00007691465	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00653281	chr1:1991051	1	1991051	PRKCZ	Island	-0.00763	0.00189	0.000077	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	ABHD12 protein levels (SeqId = 7825-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ABHD12 protein levels (SeqId = 7825-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysophosphatidylserine lipase ABHD12	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_abhd12_protein_levels__seqid___7825-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZYX protein levels (SeqId = 13632-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZYX protein levels (SeqId = 13632-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zyxin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_zyx_protein_levels__seqid___13632-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNRC6B protein levels (SeqId = 9808-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNRC6B protein levels (SeqId = 9808-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trinucleotide repeat-containing gene 6B protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_tnrc6b_protein_levels__seqid___9808-41__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CBR3 protein levels (SeqId = 14091-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBR3 protein levels (SeqId = 14091-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbonyl reductase [NADPH] 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_cbr3_protein_levels__seqid___14091-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KLK15 protein levels (SeqId = 6491-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLK15 protein levels (SeqId = 6491-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kallikrein-15	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_klk15_protein_levels__seqid___6491-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CEACAM3 protein levels (SeqId = 8999-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CEACAM3 protein levels (SeqId = 8999-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carcinoembryonic antigen-related cell adhesion molecule 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_ceacam3_protein_levels__seqid___8999-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK12 protein levels (SeqId = 5005-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK12 protein levels (SeqId = 5005-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 12	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_mapk12_protein_levels__seqid___5005-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRCP protein levels (SeqId = 17771-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRCP protein levels (SeqId = 17771-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-directed RNA polymerase III subunit RPC9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_crcp_protein_levels__seqid___17771-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CALCOCO2 protein levels (SeqId = 12534-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CALCOCO2 protein levels (SeqId = 12534-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-binding and coiled-coil domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_calcoco2_protein_levels__seqid___12534-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PNP protein levels (SeqId = 15435-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNP protein levels (SeqId = 15435-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Purine nucleoside phosphorylase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000077	None	Gadd-DA_pnp_protein_levels__seqid___15435-4__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	1.1	0.283	0.000077	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22366001	chr1:2066006	1	2066006	PRKCZ	North shore	0.0043	None	0.000077	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15468976	chr1:2106222	1	2106222	PRKCZ	Open sea	-0.0326591	0.00825871	0.00007705396	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	0.0401889	0.0101676	0.00007765878	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	-0.402581	0.1019	0.0000778	None	27105112_hiv_infection_cd4_tcells
Battram T	ARIES	None	2020-08-20	Free cholesterol in IDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	2.09	0.53	0.000078	None	Battram-T_free_cholesterol_in_idl
Gadd DA	Generation Scotland	35945220	31/07/2022	TCP1 protein levels (SeqId = 19265-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TCP1 protein levels (SeqId = 19265-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-complex protein 1 subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000078	None	Gadd-DA_tcp1_protein_levels__seqid___19265-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EIF4E protein levels (SeqId = 19263-147)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EIF4E protein levels (SeqId = 19263-147)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Eukaryotic translation initiation factor 4E	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000078	None	Gadd-DA_eif4e_protein_levels__seqid___19263-147__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ST6GAL1 protein levels (SeqId = 6035-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ST6GAL1 protein levels (SeqId = 6035-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-galactoside alpha-2,6-sialyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000078	None	Gadd-DA_st6gal1_protein_levels__seqid___6035-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HPRT1 protein levels (SeqId = 19290-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HPRT1 protein levels (SeqId = 19290-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hypoxanthine-guanine phosphoribosyltransferase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000078	None	Gadd-DA_hprt1_protein_levels__seqid___19290-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	THRA protein levels (SeqId = 12527-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THRA protein levels (SeqId = 12527-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thyroid hormone receptor alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000078	None	Gadd-DA_thra_protein_levels__seqid___12527-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0516972	0.0130842	0.00007815046	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0326039	0.00825218	0.00007820694	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21271945	chr1:2080081	1	2080081	PRKCZ	North shelf	-0.0418718	0.0106005	0.00007852708	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	-0.0325938	0.00825218	0.00007861036	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.185088	0.0468649	0.00007864271	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0570223	0.0144406	0.00007893095	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	GDI1 protein levels (SeqId = 16810-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GDI1 protein levels (SeqId = 16810-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rab GDP dissociation inhibitor alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000079	None	Gadd-DA_gdi1_protein_levels__seqid___16810-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ATP2A3 protein levels (SeqId = 13510-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ATP2A3 protein levels (SeqId = 13510-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000079	None	Gadd-DA_atp2a3_protein_levels__seqid___13510-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ETFA protein levels (SeqId = 17435-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ETFA protein levels (SeqId = 17435-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Electron transfer flavoprotein subunit alpha, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000079	None	Gadd-DA_etfa_protein_levels__seqid___17435-43__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18188739	chr1:2058941	1	2058941	PRKCZ	Open sea	0.137939	0.0349453	0.0000793578	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05340048	chr1:2084319	1	2084319	PRKCZ	South shore	-0.0325703	0.00825219	0.00007955145	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Arm circumference	EFO_0004589	None	None	DNA methylation	Arm circumference	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	cm	Illumina HumanMethylation450	Whole blood	DXA scan measurement	717	1	Adults	Females	European	cg02138098	chr1:2040968	1	2040968	PRKCZ	North shore	-0.035	0.0089	0.00008	None	Battram-T_arm_circumference
Gadd DA	Generation Scotland	35945220	31/07/2022	CHMP2A protein levels (SeqId = 17728-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHMP2A protein levels (SeqId = 17728-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Charged multivesicular body protein 2a	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_chmp2a_protein_levels__seqid___17728-61__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GPR26 protein levels (SeqId = 13540-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPR26 protein levels (SeqId = 13540-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: G-protein coupled receptor 26	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_gpr26_protein_levels__seqid___13540-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL18RAP protein levels (SeqId = 2993-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL18RAP protein levels (SeqId = 2993-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-18 receptor accessory protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_il18rap_protein_levels__seqid___2993-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2G1 protein levels (SeqId = 17158-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2G1 protein levels (SeqId = 17158-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 G1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_ube2g1_protein_levels__seqid___17158-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MRAS protein levels (SeqId = 18297-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRAS protein levels (SeqId = 18297-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein M-Ras	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_mras_protein_levels__seqid___18297-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RORB protein levels (SeqId = 12483-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RORB protein levels (SeqId = 12483-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear receptor ROR-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00008	None	Gadd-DA_rorb_protein_levels__seqid___12483-62__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19923417	chr1:2002516	1	2002516	PRKCZ	North shelf	0.00985	0.00245	0.00008	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04347414	chr1:2084519	1	2084519	PRKCZ	South shore	0.0325585	0.00825219	0.00008002523	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17495046	chr1:2017010	1	2017010	PRKCZ	Open sea	0.0046	None	0.000081	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	GAL protein levels (SeqId = 15390-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GAL protein levels (SeqId = 15390-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galanin peptides	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000081	None	Gadd-DA_gal_protein_levels__seqid___15390-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CTGF protein levels (SeqId = 2975-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTGF protein levels (SeqId = 2975-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Connective tissue growth factor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000081	None	Gadd-DA_ctgf_protein_levels__seqid___2975-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TBX5 protein levels (SeqId = 11202-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBX5 protein levels (SeqId = 11202-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-box transcription factor TBX5	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000081	None	Gadd-DA_tbx5_protein_levels__seqid___11202-70__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADM protein levels (SeqId = 14115-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADM protein levels (SeqId = 14115-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADM	774	1	Adults (18-65 years)	Both	European	cg05620928	chr1:2011702	1	2011702	PRKCZ	Open sea	-0.94	0.238	0.000081	None	Gadd-DA_adm_protein_levels__seqid___14115-34__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.034396	0.00872438	0.0000810076	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	0.0325288	0.0082522	0.00008123843	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04281981	chr1:2097062	1	2097062	PRKCZ	Open sea	0.207968	0.052773	0.00008152898	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00312809	chr1:2028213	1	2028213	PRKCZ	South shore	0.0343368	0.00871374	0.00008167735	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0325115	0.00825221	0.00008195036	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg04520340	chr1:2005132	1	2005132	PRKCZ	North shore	0.043	0.01081	0.000082	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	RCN3 protein levels (SeqId = 16858-384)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RCN3 protein levels (SeqId = 16858-384)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Reticulocalbin-3	774	1	Adults (18-65 years)	Both	European	cg12639453	chr1:2035780	1	2035780	PRKCZ	North shelf	-0.568	0.144	0.000082	None	Gadd-DA_rcn3_protein_levels__seqid___16858-384__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	USO1 protein levels (SeqId = 13639-101)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	USO1 protein levels (SeqId = 13639-101)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: General vesicular transport factor p115	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000082	None	Gadd-DA_uso1_protein_levels__seqid___13639-101__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NID2 protein levels (SeqId = 16060-99)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NID2 protein levels (SeqId = 16060-99)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nidogen-2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.551	0.14	0.000082	None	Gadd-DA_nid2_protein_levels__seqid___16060-99__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAMBP protein levels (SeqId = 19187-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAMBP protein levels (SeqId = 19187-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: STAM-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000082	None	Gadd-DA_stambp_protein_levels__seqid___19187-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CXADR protein levels (SeqId = 11204-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXADR protein levels (SeqId = 11204-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coxsackievirus and adenovirus receptor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000082	None	Gadd-DA_cxadr_protein_levels__seqid___11204-80__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0325026	0.00825221	0.00008232056	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05239544	chr1:1980895	1	1980895	PRKCZ	North shore	0.0324993	0.00825221	0.00008245523	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0325346	0.00826224	0.00008262928	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24557048	chr1:2063799	1	2063799	PRKCZ	Island	-0.0324914	0.00825221	0.0000827866	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05802244	chr1:2011082	1	2011082	PRKCZ	Open sea	-0.0047	0.0012	0.000083	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	LZIC protein levels (SeqId = 19338-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LZIC protein levels (SeqId = 19338-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein LZIC	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000083	None	Gadd-DA_lzic_protein_levels__seqid___19338-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUMO2 protein levels (SeqId = 19555-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUMO2 protein levels (SeqId = 19555-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small ubiquitin-related modifier 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000083	None	Gadd-DA_sumo2_protein_levels__seqid___19555-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSH1 protein levels (SeqId = 13103-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSH1 protein levels (SeqId = 13103-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chorionic somatomammotropin hormone 2|Chorionic somatomammotropin hormone 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000083	None	Gadd-DA_csh1_protein_levels__seqid___13103-125__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02393699	chr1:2106620	1	2106620	PRKCZ	Open sea	-0.0331112	0.00841129	0.00008305303	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17023856	chr1:2036508	1	2036508	PRKCZ	North shelf	0.0953869	0.0242314	0.00008306008	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	0.0324835	0.00825221	0.00008311541	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24577455	chr1:2069012	1	2069012	PRKCZ	South shelf	-0.0336012	0.00853951	0.00008365192	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	0.0324642	0.00825222	0.00008392867	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SPR protein levels (SeqId = 9287-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPR protein levels (SeqId = 9287-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sepiapterin reductase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000084	None	Gadd-DA_spr_protein_levels__seqid___9287-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KREMEN2 protein levels (SeqId = 3202-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KREMEN2 protein levels (SeqId = 3202-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kremen protein 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000084	None	Gadd-DA_kremen2_protein_levels__seqid___3202-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJC19 protein levels (SeqId = 4545-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJC19 protein levels (SeqId = 4545-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitochondrial import inner membrane translocase subunit TIM14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000084	None	Gadd-DA_dnajc19_protein_levels__seqid___4545-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CAMK1 protein levels (SeqId = 3592-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAMK1 protein levels (SeqId = 3592-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium/calmodulin-dependent protein kinase type 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000084	None	Gadd-DA_camk1_protein_levels__seqid___3592-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C17orf67 protein levels (SeqId = 9070-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C17orf67 protein levels (SeqId = 9070-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C17orf67	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000084	None	Gadd-DA_c17orf67_protein_levels__seqid___9070-1__somascan_protein_measurement
Amélie Taschereau	Gen3G	37386647	Jun 29, 2023	Area under the curve for glucose	None	None	None	DNA methylation	Area under the curve for glucose	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Gestational age, Gravidity	M values	mmol/L*h	Illumina HumanMethylationEPIC	Umbilical cord blood cells at birth and blood cells at 5y visit	Only CpGs with p<1x10E-4 were uploaded (COMBAT was used to correct for batch effect)	539	1	Infants	Both	European	cg23629792	chr1:1987129	1	1987129	PRKCZ	North shelf	0.015	0.0037	0.000084	None	37386647_Taschereau-A_area_under_the_curve_for_glucose
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.019	0.00477	0.000084	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.0575897	0.0146403	0.00008405677	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0324567	0.00825222	0.00008424657	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	-0.0365481	0.00929264	0.00008427242	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04314111	chr1:2003577	1	2003577	PRKCZ	North shore	0.0324553	0.00825222	0.00008430646	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0389884	0.00991778	0.00008492617	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	EEA1 protein levels (SeqId = 14043-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EEA1 protein levels (SeqId = 14043-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Early endosome antigen 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_eea1_protein_levels__seqid___14043-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	B3GALT1 protein levels (SeqId = 9541-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B3GALT1 protein levels (SeqId = 9541-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,3-galactosyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_b3galt1_protein_levels__seqid___9541-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ARL3 protein levels (SeqId = 12571-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ARL3 protein levels (SeqId = 12571-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADP-ribosylation factor-like protein 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_arl3_protein_levels__seqid___12571-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITPRIPL1 protein levels (SeqId = 9221-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITPRIPL1 protein levels (SeqId = 9221-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_itpripl1_protein_levels__seqid___9221-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GDF10 protein levels (SeqId = 16749-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GDF10 protein levels (SeqId = 16749-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Growth/differentiation factor 10	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_gdf10_protein_levels__seqid___16749-79__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNRPG protein levels (SeqId = 19276-124)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNRPG protein levels (SeqId = 19276-124)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small nuclear ribonucleoprotein G	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_snrpg_protein_levels__seqid___19276-124__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GRAMD1C protein levels (SeqId = 8336-267)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRAMD1C protein levels (SeqId = 8336-267)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein Aster-C	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_gramd1c_protein_levels__seqid___8336-267__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS4 protein levels (SeqId = 2982-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS4 protein levels (SeqId = 2982-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_lgals4_protein_levels__seqid___2982-82__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNAP29 protein levels (SeqId = 12357-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNAP29 protein levels (SeqId = 12357-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synaptosomal-associated protein 29	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000085	None	Gadd-DA_snap29_protein_levels__seqid___12357-41__somascan_protein_measurement
Battram T	GEO	25282492	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE61278. Compared fetal liver tissue to adult liver tissue of different individuals	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Fetal liver, adult liver	None	110	1	Adults	Both	European	cg24776480	chr1:2066446	1	2066446	PRKCZ	Island	-0.282	0.068	0.000085	None	25282492_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11758127	chr1:2002884	1	2002884	PRKCZ	North shelf	-0.0402869	0.0102488	0.00008502368	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06801943	chr1:2101479	1	2101479	PRKCZ	Open sea	-0.0324282	0.00825223	0.00008546783	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg15513868	chr1:2105154	1	2105154	PRKCZ	Open sea	-0.126268	0.0321	0.0000856	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	0.0324192	0.00825223	0.00008585734	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06646728	chr1:2104886	1	2104886	PRKCZ	Open sea	0.0011	None	0.000086	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	HPSE protein levels (SeqId = 5604-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HPSE protein levels (SeqId = 5604-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heparanase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000086	None	Gadd-DA_hpse_protein_levels__seqid___5604-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPS6KA1 protein levels (SeqId = 12329-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPS6KA1 protein levels (SeqId = 12329-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosomal protein S6 kinase alpha-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000086	None	Gadd-DA_rps6ka1_protein_levels__seqid___12329-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19928739	chr1:2089555	1	2089555	PRKCZ	Open sea	-0.0324085	0.00825223	0.00008632175	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17497824	chr1:2021003	1	2021003	PRKCZ	Open sea	0.0324059	0.00825224	0.00008643081	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0323995	0.00825224	0.0000867106	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINF2 protein levels (SeqId = 3024-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINF2 protein levels (SeqId = 3024-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-2-antiplasmin	774	1	Adults (18-65 years)	Both	European	cg08106205	chr1:2062664	1	2062664	PRKCZ	North shore	-1.03	0.262	0.000087	None	Gadd-DA_serpinf2_protein_levels__seqid___3024-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BDNF protein levels (SeqId = 14047-78)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDNF protein levels (SeqId = 14047-78)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Brain-derived neurotrophic factor	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000087	None	Gadd-DA_bdnf_protein_levels__seqid___14047-78__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EDN1 protein levels (SeqId = 6495-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EDN1 protein levels (SeqId = 6495-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endothelin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000087	None	Gadd-DA_edn1_protein_levels__seqid___6495-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BTK protein levels (SeqId = 19202-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTK protein levels (SeqId = 19202-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tyrosine-protein kinase BTK	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000087	None	Gadd-DA_btk_protein_levels__seqid___19202-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SMIM9 protein levels (SeqId = 8888-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMIM9 protein levels (SeqId = 8888-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small integral membrane protein 9	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000087	None	Gadd-DA_smim9_protein_levels__seqid___8888-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00175702	chr1:2109388	1	2109388	PRKCZ	Open sea	-0.0323924	0.00825224	0.00008702432	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00409816	chr1:2037476	1	2037476	PRKCZ	North shore	-0.0371033	0.00945371	0.00008722293	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	-0.0323864	0.00825224	0.00008728631	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14915244	chr1:2080213	1	2080213	PRKCZ	North shelf	-0.0323729	0.00825224	0.00008788001	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06340969	chr1:1990780	1	1990780	PRKCZ	Island	1.9	0.47	0.000088	None	Battram-T_free_cholesterol_in_large_ldl
Gadd DA	Generation Scotland	35945220	31/07/2022	PNPO protein levels (SeqId = 17804-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNPO protein levels (SeqId = 17804-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyridoxine-5'-phosphate oxidase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000088	None	Gadd-DA_pnpo_protein_levels__seqid___17804-102__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09560161	chr1:2065242	1	2065242	PRKCZ	North shore	-0.0323565	0.00825225	0.00008860637	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00300046	chr1:2084595	1	2084595	PRKCZ	South shelf	-0.0323499	0.00825225	0.00008890532	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IL20RA protein levels (SeqId = 5085-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL20RA protein levels (SeqId = 5085-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-20 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000089	None	Gadd-DA_il20ra_protein_levels__seqid___5085-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CREBBP protein levels (SeqId = 13614-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CREBBP protein levels (SeqId = 13614-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CREB-binding protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000089	None	Gadd-DA_crebbp_protein_levels__seqid___13614-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNF4A protein levels (SeqId = 10041-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNF4A protein levels (SeqId = 10041-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatocyte nuclear factor 4-alpha	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000089	None	Gadd-DA_hnf4a_protein_levels__seqid___10041-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CBX3 protein levels (SeqId = 18868-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBX3 protein levels (SeqId = 18868-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chromobox protein homolog 3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000089	None	Gadd-DA_cbx3_protein_levels__seqid___18868-7__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg14743859	chr1:2066274	1	2066274	PRKCZ	North shore	-1.4	0.357	0.000089	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07382156	chr1:2085526	1	2085526	PRKCZ	South shelf	-0.0323347	0.00825225	0.00008958514	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24937768	chr1:2092853	1	2092853	PRKCZ	Open sea	-0.173271	0.0442287	0.00008975618	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	WWP1 protein levels (SeqId = 11307-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WWP1 protein levels (SeqId = 11307-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NEDD4-like E3 ubiquitin-protein ligase WWP1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_wwp1_protein_levels__seqid___11307-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAT14 protein levels (SeqId = 11120-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAT14 protein levels (SeqId = 11120-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-acetyltransferase 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_nat14_protein_levels__seqid___11120-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GCLM protein levels (SeqId = 18214-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GCLM protein levels (SeqId = 18214-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutamate--cysteine ligase regulatory subunit	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_gclm_protein_levels__seqid___18214-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRYBB1 protein levels (SeqId = 17751-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRYBB1 protein levels (SeqId = 17751-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-crystallin B1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_crybb1_protein_levels__seqid___17751-68__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DIXDC1 protein levels (SeqId = 13441-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DIXDC1 protein levels (SeqId = 13441-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dixin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_dixdc1_protein_levels__seqid___13441-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AIF1 protein levels (SeqId = 2849-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AIF1 protein levels (SeqId = 2849-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Allograft inflammatory factor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.00009	None	Gadd-DA_aif1_protein_levels__seqid___2849-49__somascan_protein_measurement
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0049	0.0012	0.00009	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0323078	0.00825226	0.00009080562	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	USP14 protein levels (SeqId = 19189-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	USP14 protein levels (SeqId = 19189-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin carboxyl-terminal hydrolase 14	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000091	None	Gadd-DA_usp14_protein_levels__seqid___19189-2__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.22	0.0561	0.000091	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06204101	chr1:2039671	1	2039671	PRKCZ	North shore	0.0369956	0.0094523	0.00009121788	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Pulse rate	NCIT_C49676	None	None	DNA methylation	Pulse rate	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	702	1	Adults	Females	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0144	0.0037	0.000092	None	Battram-T_pulse_rate
Battram T	ARIES	None	2020-08-20	Total region fat	EFO_0005409	None	None	DNA methylation	Total region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-1.35	0.34	0.000092	None	Battram-T_total_region_fat
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07912723	chr1:2032058	1	2032058	PRKCZ	Open sea	-0.00042	0.00011	0.000092	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	HMOX2 protein levels (SeqId = 2622-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HMOX2 protein levels (SeqId = 2622-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heme oxygenase 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000092	None	Gadd-DA_hmox2_protein_levels__seqid___2622-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDK1 protein levels (SeqId = 5227-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDK1 protein levels (SeqId = 5227-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000092	None	Gadd-DA_pdk1_protein_levels__seqid___5227-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PAK4 protein levels (SeqId = 13719-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAK4 protein levels (SeqId = 13719-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase PAK 4	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000092	None	Gadd-DA_pak4_protein_levels__seqid___13719-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CLTA protein levels (SeqId = 19257-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLTA protein levels (SeqId = 19257-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Clathrin light chain A	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000092	None	Gadd-DA_clta_protein_levels__seqid___19257-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14171824	chr1:2006656	1	2006656	PRKCZ	South shore	-0.035959	0.00919371	0.00009222909	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02138098	chr1:2040968	1	2040968	PRKCZ	North shore	-0.12288	0.0314296	0.00009274821	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07693617	chr1:2081984	1	2081984	PRKCZ	North shore	0.00069	0.00018	0.000093	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Odintsova VV	Netherlands Twin Register	31744183	2019-11-17	Breastfeeding	EFO_0006864	Discovery, basic model, total sample	Table S8	DNA methylation	Breastfeeding	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Buccal cells	None	1006	1	Children	Both	European	cg14656575	chr1:1988767	1	1988767	PRKCZ	North shelf	-0.0063	0.00162	0.000093	None	31744183_Odintsova-VV_breastfeeding_discovery__basic_model__total_sample
Gadd DA	Generation Scotland	35945220	31/07/2022	GABARAPL2 protein levels (SeqId = 12494-99)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GABARAPL2 protein levels (SeqId = 12494-99)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gamma-aminobutyric acid receptor-associated protein-like 2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000093	None	Gadd-DA_gabarapl2_protein_levels__seqid___12494-99__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg25726135	chr1:2088708	1	2088708	PRKCZ	Open sea	-0.179859	0.046011	0.00009300077	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24138964	chr1:2025206	1	2025206	PRKCZ	Island	-0.0322562	0.00825228	0.00009318838	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00456448	chr1:2109543	1	2109543	PRKCZ	Open sea	0.0322523	0.00825228	0.00009336759	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	0.0412599	0.0105599	0.00009377659	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11227141	chr1:2003650	1	2003650	PRKCZ	North shore	-0.0328036	0.00839662	0.00009395944	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Android region fat	EFO_0005409	None	None	DNA methylation	Android region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-1.03	0.26	0.000094	None	Battram-T_android_region_fat
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg07222721	chr1:2099745	1	2099745	PRKCZ	Open sea	-0.13	0.0343	0.000094	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINE2 protein levels (SeqId = 19154-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINE2 protein levels (SeqId = 19154-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glia-derived nexin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000094	None	Gadd-DA_serpine2_protein_levels__seqid___19154-41__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASE2 protein levels (SeqId = 8394-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASE2 protein levels (SeqId = 8394-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Non-secretory ribonuclease	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000094	None	Gadd-DA_rnase2_protein_levels__seqid___8394-56__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB103A protein levels (SeqId = 5679-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB103A protein levels (SeqId = 5679-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 103	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.547	0.14	0.000094	None	Gadd-DA_defb103a_protein_levels__seqid___5679-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TP53I3 protein levels (SeqId = 17748-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TP53I3 protein levels (SeqId = 17748-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Quinone oxidoreductase PIG3	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000094	None	Gadd-DA_tp53i3_protein_levels__seqid___17748-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA1024 protein levels (SeqId = 9075-121)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA1024 protein levels (SeqId = 9075-121)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Major intrinsically disordered Notch2-binding receptor 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000094	None	Gadd-DA_kiaa1024_protein_levels__seqid___9075-121__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPP3R1 protein levels (SeqId = 15545-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPP3R1 protein levels (SeqId = 15545-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcineurin subunit B type 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000094	None	Gadd-DA_ppp3r1_protein_levels__seqid___15545-13__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Albumin	EFO_0004535	None	None	DNA methylation	Albumin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg25976434	chr1:2008510	1	2008510	PRKCZ	South shelf	-28	7.1	0.000094	None	Battram-T_albumin
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19412821	chr1:2104786	1	2104786	PRKCZ	Open sea	0.134148	0.034346	0.00009427385	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00866690	chr1:2066631	1	2066631	PRKCZ	Island	0.0362617	0.00928569	0.00009460196	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08109625	chr1:2036643	1	2036643	PRKCZ	North shore	-0.0419019	0.0107313	0.00009478984	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09260853	chr1:2094483	1	2094483	PRKCZ	Open sea	-0.0322201	0.00825228	0.00009488737	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF526 protein levels (SeqId = 14619-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF526 protein levels (SeqId = 14619-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 526	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000095	None	Gadd-DA_znf526_protein_levels__seqid___14619-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	APLN protein levels (SeqId = 6622-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APLN protein levels (SeqId = 6622-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apelin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000095	None	Gadd-DA_apln_protein_levels__seqid___6622-90__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPA1 protein levels (SeqId = 5021-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPA1 protein levels (SeqId = 5021-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inorganic pyrophosphatase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000095	None	Gadd-DA_ppa1_protein_levels__seqid___5021-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KYNU protein levels (SeqId = 4559-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KYNU protein levels (SeqId = 4559-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kynureninase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000095	None	Gadd-DA_kynu_protein_levels__seqid___4559-64__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20328379	chr1:2048946	1	2048946	PRKCZ	South shelf	-0.0012	0.00031	0.000095	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08439149	chr1:2004163	1	2004163	PRKCZ	North shore	0.0322124	0.00825229	0.00009525337	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	None	None	0.000096	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PGK1 protein levels (SeqId = 5020-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGK1 protein levels (SeqId = 5020-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglycerate kinase 1	774	1	Adults (18-65 years)	Both	European	cg18803110	chr1:2057439	1	2057439	PRKCZ	Open sea	-0.44	0.114	0.000096	None	Gadd-DA_pgk1_protein_levels__seqid___5020-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TAPBP protein levels (SeqId = 12378-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAPBP protein levels (SeqId = 12378-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tapasin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000096	None	Gadd-DA_tapbp_protein_levels__seqid___12378-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NAGS protein levels (SeqId = 11247-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAGS protein levels (SeqId = 11247-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-acetylglutamate synthase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000096	None	Gadd-DA_nags_protein_levels__seqid___11247-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SCT protein levels (SeqId = 3728-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCT protein levels (SeqId = 3728-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Secretin	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000096	None	Gadd-DA_sct_protein_levels__seqid___3728-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSNK2A2 protein levels (SeqId = 5226-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSNK2A2 protein levels (SeqId = 5226-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Casein kinase II subunit alpha'|Casein kinase II subunit beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000096	None	Gadd-DA_csnk2a2_protein_levels__seqid___5226-36__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	STAB1 protein levels (SeqId = 14599-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAB1 protein levels (SeqId = 14599-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stabilin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000096	None	Gadd-DA_stab1_protein_levels__seqid___14599-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26335530	chr1:2060642	1	2060642	PRKCZ	North shelf	0.0338194	0.00867078	0.00009646877	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06176608	chr1:2019526	1	2019526	PRKCZ	Open sea	-0.0350938	0.00899974	0.00009685086	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03377392	chr1:2001321	1	2001321	PRKCZ	North shelf	-0.0433621	0.0111205	0.00009690273	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Android tissue fat	EFO_0005409	None	None	DNA methylation	Android tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-1.02	0.26	0.000097	None	Battram-T_android_tissue_fat
Battram T	ARIES	None	2020-08-20	Total tissue fat	EFO_0005409	None	None	DNA methylation	Total tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg02347356	chr1:1983003	1	1983003	PRKCZ	Island	-1.31	0.33	0.000097	None	Battram-T_total_tissue_fat
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg10219789	chr1:2092526	1	2092526	PRKCZ	Open sea	-0.025	0.00635	0.000097	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	RB1 protein levels (SeqId = 5024-67)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RB1 protein levels (SeqId = 5024-67)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinoblastoma-associated protein	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_rb1_protein_levels__seqid___5024-67__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANGPT1 protein levels (SeqId = 2811-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANGPT1 protein levels (SeqId = 2811-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Angiopoietin-1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_angpt1_protein_levels__seqid___2811-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EPDR1 protein levels (SeqId = 9040-144)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPDR1 protein levels (SeqId = 9040-144)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mammalian ependymin-related protein 1	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_epdr1_protein_levels__seqid___9040-144__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM171A2 protein levels (SeqId = 13479-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM171A2 protein levels (SeqId = 13479-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FAM171A2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_fam171a2_protein_levels__seqid___13479-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KARS protein levels (SeqId = 19249-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KARS protein levels (SeqId = 19249-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysine--tRNA ligase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_kars_protein_levels__seqid___19249-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BTLA protein levels (SeqId = 16308-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTLA protein levels (SeqId = 16308-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: B- and T-lymphocyte attenuator	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_btla_protein_levels__seqid___16308-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SMIM13 protein levels (SeqId = 13452-113)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMIM13 protein levels (SeqId = 13452-113)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small integral membrane protein 13	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000097	None	Gadd-DA_smim13_protein_levels__seqid___13452-113__somascan_protein_measurement
van Dongen J	ALSPAC, GECKO, Generation R, INMA, Poseidon	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Fully adjusted meta-analysis in cord blood	eTable 7	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects , body mass index, smoking	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Cord blood	None	2425	5	Infants	Both	Unclear	cg26910870	chr1:2046928	1	2046928	PRKCZ	South shore	None	None	0.000097	None	33420481_van-Dongen-J_aggressive_behaviour_fully_adjusted_meta-analysis_in_cord_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16599817	chr1:2036283	1	2036283	PRKCZ	North shelf	0.0333796	0.00856183	0.00009715803	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00981070	chr1:2046702	1	2046702	PRKCZ	Island	0.0321702	0.0082523	0.00009728857	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26430365	chr1:2103575	1	2103575	PRKCZ	Open sea	-0.0321694	0.0082523	0.00009732642	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	-0.0321666	0.0082523	0.00009746319	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18938190	chr1:2094291	1	2094291	PRKCZ	Open sea	0.0346022	0.00887733	0.00009749644	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24842354	chr1:2004057	1	2004057	PRKCZ	North shore	0.0321633	0.0082523	0.00009762599	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16735509	chr1:2023157	1	2023157	PRKCZ	North shelf	-0.0321582	0.0082523	0.00009787329	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SLC35G2 protein levels (SeqId = 13501-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLC35G2 protein levels (SeqId = 13501-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Solute carrier family 35 member G2	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000098	None	Gadd-DA_slc35g2_protein_levels__seqid___13501-10__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20250605	chr1:2046506	1	2046506	PRKCZ	Island	-0.0064	0.00161	0.000098	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15115072	chr1:2002722	1	2002722	PRKCZ	North shelf	0.0321461	0.0082523	0.00009847036	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RRM2B protein levels (SeqId = 8925-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RRM2B protein levels (SeqId = 8925-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonucleoside-diphosphate reductase subunit M2 B	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000099	None	Gadd-DA_rrm2b_protein_levels__seqid___8925-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPCS protein levels (SeqId = 17843-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPCS protein levels (SeqId = 17843-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphopantothenate--cysteine ligase	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000099	None	Gadd-DA_ppcs_protein_levels__seqid___17843-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN2 protein levels (SeqId = 8876-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN2 protein levels (SeqId = 8876-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-2-beta	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000099	None	Gadd-DA_nrxn2_protein_levels__seqid___8876-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SENP7 protein levels (SeqId = 12626-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SENP7 protein levels (SeqId = 12626-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sentrin-specific protease 7	774	1	Adults (18-65 years)	Both	European	cg19646139	chr1:2029012	1	2029012	PRKCZ	South shelf	-0.55	0.14	0.000099	None	Gadd-DA_senp7_protein_levels__seqid___12626-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00239751	chr1:2082848	1	2082848	PRKCZ	South shore	0.032127	0.00825231	0.00009941374	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17435831	chr1:2082522	1	2082522	PRKCZ	Island	-0.0321207	0.00825231	0.00009972733	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04023573	chr1:2004636	1	2004636	PRKCZ	North shore	0.0323588	0.0083145	0.0000999213	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3