author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.008 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.032 0.00091 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg00079023 chr5:139492535 5 139492535 PURA North shore - - 0 - 26500701_sex_metaanalysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08898234 chr5:139493558 5 139493558 PURA North shore 0.00071 0.000064 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.013 0.00031 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.05 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.026 0.0031 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.0067 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.02 0.00098 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg00079023 chr5:139492535 5 139492535 PURA North shore - - 4.65e-143 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg11067714 chr5:139492230 5 139492230 PURA North shore - - 2.6e-138 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg14640670 chr5:139494937 5 139494937 PURA South shore - - 9.25e-94 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.12517 0.00379 2.7e-81 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.06464 0.00254 1.3e-63 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg00079023 chr5:139492535 5 139492535 PURA North shore -1.34163 0.05903 2.37e-38 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg11067714 chr5:139492230 5 139492230 PURA North shore -1.52263 0.06896 2.01e-37 - 25282492_fetal_vs_adult_liver Kachroo P None 33468710 2021-01-19 Age EFO_0000246 Fetal age Table 2a DNA methylation Age in-utero-smoke exposure to cotinine, sex, batch effects Beta Values days Illumina HumanMethylation450 Lung None 78 1 Infants Both Admixed cg11067714 chr5:139492230 5 139492230 PURA North shore 0.006 0.00049 6.699999999999999e-35 None 33468710_Kachroo-P_age_fetal_age Kachroo P None 33468710 2021-01-19 Age EFO_0000246 Fetal age Table 2a DNA methylation Age in-utero-smoke exposure to cotinine, sex, batch effects Beta Values days Illumina HumanMethylation450 Lung None 78 1 Infants Both Admixed cg00079023 chr5:139492535 5 139492535 PURA North shore 0.003 0.00024 1.0000000000000001e-34 None 33468710_Kachroo-P_age_fetal_age Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21778810 chr5:139493680 5 139493680 PURA Island -0.04585 0.00334 2.2000000000000002e-30 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.04542 0.00425 3e-21 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.355721 0.0379001 7.003662e-21 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.340618 0.0368848 2.869429e-20 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg00079023 chr5:139492535 5 139492535 PURA North shore - - 7.94e-20 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0730851 0.00846844 6.741252e-18 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.0681812 0.00823736 1.370345e-16 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -2.7 0.326 1.6e-16 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23160717 chr5:139493486 5 139493486 PURA North shore -0.00016 0.000019 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14640670 chr5:139494937 5 139494937 PURA South shore - - 5.95e-16 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.29413 0.0368759 0.000000000000001602421 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.00093 0.00012 0.0000000000000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.017 0.0021 0.0000000000000033 None 33450751_Mulder-RH_sex_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.28002 0.0358458 0.000000000000005942637 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.0637956 0.00823975 0.00000000000001038939 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.291976 0.037902 0.00000000000001395892 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03987227 chr5:139494540 5 139494540 PURA Island 0.00708 0.00089 0.00000000000012 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.279563 0.0380241 0.0000000000002036068 None 39706196_Hannah-M.-Smith_body_fat_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -2.4 0.333 0.00000000000021 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.273198 0.0385137 0.000000000001357804 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0601097 0.00850178 0.000000000001616491 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0083 0.0012 0.0000000000017 None 33450751_Mulder-RH_sex_discovery Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg11067714 chr5:139492230 5 139492230 PURA North shore None None 0.0000000000017 None 31789449_Dugue-P-A_alcohol_consumption_replication Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.271764 0.0386027 0.00000000000199411 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.05916 0.00849405 0.000000000003426691 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.256221 0.0369769 0.00000000000438091 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0569312 0.00824318 0.000000000005173135 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11067714 chr5:139492230 5 139492230 PURA North shore - - 0.0000000000187 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0551444 0.00824401 0.00000000002327993 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.246722 0.0374132 0.00000000004383572 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0555329 0.0084929 0.00000000006409261 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.388833 0.0597913 0.00000000008080025 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg11067714 chr5:139492230 5 139492230 PURA North shore 0.10577 0.0163 0.0000000000892 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0550534 0.00848939 0.00000000009158826 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0547801 0.00848847 0.0000000001127487 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0545755 0.0084758 0.0000000001240268 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18423568 chr5:139493544 5 139493544 PURA North shore -0.00007 0.000011 0.0000000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.042 0.00672 0.00000000031 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0535631 0.00856521 0.0000000004122899 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0514973 0.00824562 0.0000000004343336 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0057 0.00084 0.00000000047 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0512275 0.00824573 0.0000000005351914 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14263565 chr5:139492366 5 139492366 PURA North shore -0.166299 0.0276523 0.000000001845538 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0041 0.00063 0.0000000019 None 33564054_Kashima-K_gestational_age Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 1.6 0.266 0.0000000021 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.354707 0.0594175 0.00000000242278 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0483189 0.0081295 0.000000002850776 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Sharp GC - 28603561 2017-06-08 Cleft palate vs cleft lip EFO_0003959, HP_0000175 - Additional file 5 DNA methylation Cleft palate vs cleft lip Sex and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 98 1 0 Both European,Other cg00079023 chr5:139492535 5 139492535 PURA North shore 0.03381696 0.00509558 0.00000000296 - 28603561_cleft_palate_vs_cleft_lip Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.288466 0.0490569 0.000000004172625 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.286862 0.0489452 0.000000004688021 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0473032 0.00824733 0.000000009909578 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27111970 chr5:139492957 5 139492957 PURA Island 0.00722 0.00121 0.00000001 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.220729 0.038503 0.00000001004558 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11067714 chr5:139492230 5 139492230 PURA North shore None None 0.000000011 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg00042246 chr5:139493490 5 139493490 PURA North shore 1.675187 0.2934 0.0000000113 - 27105112_hiv_infection_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.328785 0.057993 0.00000001454858 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.267398 0.047648 0.00000002029695 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.045821 0.0082479 0.00000002816654 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11067714 chr5:139492230 5 139492230 PURA North shore None None 0.00000003 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0470597 0.00849823 0.00000003119341 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg03987227 chr5:139494540 5 139494540 PURA Island 0.00671 0.0012 0.0000000428 - 23334450_rheumatoid_arthritis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13613983 chr5:139493546 5 139493546 PURA North shore 0.003 0.00055 0.000000049 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.044854 0.00824826 0.00000005474631 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14263565 chr5:139492366 5 139492366 PURA North shore 0.153971 0.0283337 0.00000005578472 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21778810 chr5:139493680 5 139493680 PURA Island 0.00076 None 0.000000069 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0444797 0.0082484 0.00000007055149 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg11593111 chr5:139493674 5 139493674 PURA Island 0.00767 0.0014 0.0000000709 - 23334450_rheumatoid_arthritis Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 1.2 0.231 0.000000078 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08898234 chr5:139493558 5 139493558 PURA North shore 0.0022 0.00041 0.000000079 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0452107 0.00842707 0.00000008220949 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0441229 0.00824853 0.00000008968043 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Guida F - 25556184 2015-04-15 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S1 DNA methylation Smoking Cell counts and technical covariates M values - Illumina HumanMethylation450 Whole blood - 582 2 54 Females European cg00534655 chr5:139492727 5 139492727 PURA Island -0.08 0.015 0.0000000906 - 25556184_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0440851 0.00824854 0.0000000919786 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0440097 0.00824857 0.00000009673201 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.044189 0.00832554 0.0000001126653 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg00079023 chr5:139492535 5 139492535 PURA North shore - - 0.000000119 - 26500701_sex_kora_f3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.313879 0.0595991 0.0000001407138 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg27111970 chr5:139492957 5 139492957 PURA Island 0.00589 0.0011 0.000000162 - 23334450_rheumatoid_arthritis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg11067714 chr5:139492230 5 139492230 PURA North shore - - 0.000000175 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.0429479 0.00824895 0.0000001950669 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0432783 0.00834744 0.0000002193368 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Chen Y None 34670603 Oct 20, 2021 Waist Circumference EFO_0004342 Multi-ethnic Asian meta-analysis None Waist Circumference DNA methylation Age, Sex, Smoking, Cell composition (reference free), control probe PCs cm Beta values Illumina HumanMethylationEPIC Whole blood None 409 None Adults (18-65 years) Both East Asian, South Asian, Admixed cg14640670 chr5:139494937 5 139494937 PURA South shore -106 20.5 0.00000024 None 34670603_Chen-Y_waist_circumference_multi-ethnic_asian_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0442521 0.00861013 0.0000002789476 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0041 0.00081 0.00000033 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0046 0.0009 0.00000037 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg00079023 chr5:139492535 5 139492535 PURA North shore 0.005 0.001 0.000000374 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg00079023 chr5:139492535 5 139492535 PURA North shore 0.004 0.001 0.000000388 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0416188 0.00824942 0.0000004588007 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0435457 0.00864219 0.0000004741767 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0428391 0.00850984 0.0000004858814 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0416412 0.00832854 0.0000005804762 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg00079023 chr5:139492535 5 139492535 PURA North shore 0.004 0.001 0.000000604 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg00079023 chr5:139492535 5 139492535 PURA North shore None None 0.00000068 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Chen Y None 34670603 Oct 20, 2021 Body mass index EFO_0004340 Multi-ethnic Asian meta-analysis None Body mass index DNA methylation Age, Sex, Smoking, Cell composition (reference free), control probe PCs kg/m2 Beta values Illumina HumanMethylationEPIC Whole blood None 409 None Adults (18-65 years) Both East Asian, South Asian, Admixed cg14640670 chr5:139494937 5 139494937 PURA South shore -41.3 8.4 0.00000085 None 34670603_Chen-Y_body_mass_index_multi-ethnic_asian_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0409392 0.00834021 0.0000009268834 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0415757 0.00851205 0.000001048752 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg15563057 chr5:139493612 5 139493612 PURA Island 0.16028 0.0331644 0.000001356534 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0397965 0.00825003 0.000001422629 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.039679 0.00825007 0.000001527842 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg11067714 chr5:139492230 5 139492230 PURA North shore 0.006 0.001 0.00000159 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.00052546 0.00010977 0.00000193 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08898234 chr5:139493558 5 139493558 PURA North shore 0.00605 0.00124 0.000002 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0401238 0.00844125 0.000002020165 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12894709 chr5:139493664 5 139493664 PURA Island -0.00012 0.000026 0.0000021 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.03911 0.00834447 0.00000279825 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0383896 0.00825049 0.000003299753 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11067714 chr5:139492230 5 139492230 PURA North shore None None 0.0000034 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.00021233 4.58e-05 0.0000036 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0386548 0.00833993 0.00000360186 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00042246 chr5:139493490 5 139493490 PURA North shore 0.00099 None 0.0000038 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0378731 0.00825065 0.000004462395 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0387614 0.00850716 0.00000524756 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.248177 0.0547193 0.000005784511 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0385557 0.00850377 0.000005834935 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0373832 0.0082508 0.000005920746 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.1 0.0226 0.0000061 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0380344 0.0084172 0.000006272034 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13613983 chr5:139493546 5 139493546 PURA North shore 0.00037 0.000083 0.0000066 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14263565 chr5:139492366 5 139492366 PURA North shore 0.12795 0.0284062 0.000006703111 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0376211 0.00835573 0.00000676968 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.219733 0.0489271 0.000007134065 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.0370564 0.0082509 0.000007136509 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0380689 0.00850138 0.000007592705 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 CD14+ monocytes Table S7 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 CD14+ monocytes - 1251 1 60 Both European,African,Admixed cg11067714 chr5:139492230 5 139492230 PURA North shore -0.000368 8.18e-05 0.00000764 - 27843151_alcohol_consumption_per_day_cd14_monocytes Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0380448 0.00850536 0.000007769493 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg00079023 chr5:139492535 5 139492535 PURA North shore None None 0.0000079 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.164733 0.0368936 0.000008054156 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg11067714 chr5:139492230 5 139492230 PURA North shore 0.007 0.002 0.00000875 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0365572 0.00825105 0.000009464532 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0376757 0.00851438 0.000009716333 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0364457 0.00825109 0.00001007606 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25813919 chr5:139496526 5 139496526 PURA South shore 0.0363583 0.00825111 0.00001058158 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13613983 chr5:139493546 5 139493546 PURA North shore 0.0363541 0.00825111 0.0000106059 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14263565 chr5:139492366 5 139492366 PURA North shore -0.0362449 0.00825731 0.0000114439 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.038 0.00867 0.000012 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0360994 0.00825119 0.00001222415 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore None None 0.000013 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0363757 0.00834493 0.00001315414 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25813919 chr5:139496526 5 139496526 PURA South shore 0.0356648 0.00822682 0.00001466076 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Sharp GC - 25855720 2015-08-01 Maternal underweight EFO_0005936 Birth Additional file 1 DNA methylation Maternal underweight Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 601 1 0 Both European cg23160717 chr5:139493486 5 139493486 PURA North shore 0.01974 0.00456 0.0000149 - 25855720_maternal_underweight_birth Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island None None 0.000015 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0365939 0.00849104 0.00001645349 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08898234 chr5:139493558 5 139493558 PURA North shore 0.00038 None 0.000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11593111 chr5:139493674 5 139493674 PURA Island -0.00012 0.000029 0.000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.074 0.0173 0.00002 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg23160717 chr5:139493486 5 139493486 PURA North shore 1.166525 0.2735 0.00002 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0368414 0.00864328 0.00002034744 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.035133 0.00825147 0.00002077452 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0366265 0.00863537 0.00002234388 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0349618 0.00825152 0.00002278959 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0351703 0.00832056 0.00002383439 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13613983 chr5:139493546 5 139493546 PURA North shore 0.0347623 0.00825158 0.00002537325 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0359829 0.00854755 0.00002572034 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0345847 0.00825163 0.0000279035 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.0345722 0.00825164 0.00002809085 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.0355748 0.00851099 0.00002933678 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0344605 0.00825167 0.00002981497 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.034792 0.00834766 0.00003092122 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11067714 chr5:139492230 5 139492230 PURA North shore 0.00049318 0.00011838 0.0000335 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21778810 chr5:139493680 5 139493680 PURA Island 0.0342508 0.0082732 0.00003492873 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25813919 chr5:139496526 5 139496526 PURA South shore 0.0341337 0.00826592 0.00003656507 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0340097 0.0082518 0.00003784971 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore -0.0339478 0.00825181 0.00003910201 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25813919 chr5:139496526 5 139496526 PURA South shore 0.0339288 0.00825182 0.00003949285 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.00033789 8.2e-05 0.0000407 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0337574 0.00826529 0.00004445802 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg00534655 chr5:139492727 5 139492727 PURA Island -0.0053 0.0013 0.000048 - 27651444_smoking_current_vs_never_smoking Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting insulin EFO_0004466 Base Supplementary Data 1 DNA methylation fasting insulin Age, sex, smoking, cell composition (reference based), batch effects Beta Values log pmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 1.07 0.26 0.000049 4740 31197173_Liu-J_fasting_insulin_base Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18423568 chr5:139493544 5 139493544 PURA North shore 0.00467 0.00112 0.000049 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0349385 0.00862922 0.00005173284 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11067714 chr5:139492230 5 139492230 PURA North shore -0.0333189 0.00826465 0.00005570348 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.0385037 0.00955185 0.00005581457 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.225848 0.0563052 0.000060681 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14640670 chr5:139494937 5 139494937 PURA South shore -0.224233 0.0559425 0.00006142265 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0330376 0.00825206 0.00006270506 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21778810 chr5:139493680 5 139493680 PURA Island 0.0021 None 0.000067 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00079023 chr5:139492535 5 139492535 PURA North shore 0.0329044 0.0082521 0.00006712717 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00042246 chr5:139493490 5 139493490 PURA North shore 0.0029 None 0.000071 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534655 chr5:139492727 5 139492727 PURA Island 0.0544985 0.0137304 0.00007246504 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14263565 chr5:139492366 5 139492366 PURA North shore 0.0328636 0.00828393 0.00007308105 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Battram T GEO 27886173 2020-09-15 Ulcerative colitis EFO_0000729 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Ulcerative colitis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 163 1 Adults Both European cg00534655 chr5:139492727 5 139492727 PURA Island -0.0152 0.00374 0.000083 None 27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg11067714 chr5:139492230 5 139492230 PURA North shore -0.00231 0.00059 0.000083 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg21778810 chr5:139493680 5 139493680 PURA Island 0.0841525 0.0214556 0.00008807962 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14640670 chr5:139494937 5 139494937 PURA South shore 0.0321931 0.00825229 0.00009617838 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1