author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0025 0.000099 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.00097 0.000075 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea -0.0015 0.00013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0031 0.00013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore 0.001 0.000076 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore 0.012 0.00026 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.035 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.034 0.0026 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0049 0.00028 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.03 0.0016 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.032 0.0027 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore 0.0059 0.0002 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.023 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.018 0.002 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.0013 None 1.6e-184 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25840536 chr15:65032585 15 65032585 RBPMS2 Open sea 0.3457 0.00466 7e-144 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05265071 chr15:65032946 15 65032946 RBPMS2 Open sea 0.57866 0.0086 6.4e-136 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore - - 1.3e-131 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00656513 chr15:65064535 15 65064535 RBPMS2 North shelf 0.26165 0.00545 3.3e-109 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.0471 0.0019 5.8e-62 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.07896 0.00319 9.3e-62 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -2.97871 0.06713 1.5599999999999998e-61 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -3.25118 0.0833 6.47e-57 - 25282492_fetal_vs_adult_liver Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore 0.05604 0.00249 5.9e-56 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.04807 0.0023 2.3e-51 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.0036 None 7.700000000000001e-48 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -2.6275 0.09293 1.26e-45 - 25282492_fetal_vs_adult_liver Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore 0.00083 None 2.2e-45 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3629243 (gene symbol: RBPMS2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3629243 (gene symbol: RBPMS2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore None None 1.4e-37 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3629243__gene_symbol__rbpms2__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05926186 chr15:65042209 15 65042209 RBPMS2 Open sea 0.03294 0.00209 2e-36 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -1.92833 0.09064 3.1e-36 - 25282492_fetal_vs_adult_liver Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea - - 6.580000000000001e-32 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0939267 0.00822007 4.13312e-30 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0902466 0.00822288 6.467507e-28 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0888173 0.00822394 4.359457e-27 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0872045 0.00822512 3.61913e-26 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0012 None 1.7e-23 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea 0.02293 0.00206 1.7000000000000002e-22 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0009 None 3.6000000000000003e-22 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore - - 1.29e-21 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0751927 0.0082332 7.528705e-20 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore - - 7.75e-20 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0747446 0.00823348 1.242989e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0746736 0.00823352 1.3453289999999998e-19 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.03369 0.00342 8.7e-19 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0715727 0.0082354 3.972928e-18 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0713408 0.00823553 5.088773e-18 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01230639 chr15:65032199 15 65032199 RBPMS2 Open sea 0.03457 0.00375 5.2e-17 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0712555 0.0086059 1.339035e-16 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0678947 0.00823752 1.833889e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0708497 0.00860269 1.93369e-16 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0664662 0.00823831 7.700525e-16 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0648914 0.00823917 0.00000000000000361721 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0640885 0.0082396 0.000000000000007850065 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22159557 chr15:65067668 15 65067668 RBPMS2 Island 0.02936 0.00356 0.000000000000024 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.305035 0.0409092 0.0000000000000929087 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea - - 0.0000000000000965 - 24500968_pancreatic_ductal_adenocarcinoma Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore 0.0051 0.00061 0.00000000000015 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.060253 0.00824157 0.0000000000002791409 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.192696 0.0271219 0.000000000001251941 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.057908 0.00824272 0.000000000002229256 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0572365 0.00824304 0.000000000003982516 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.056398 0.00824343 0.000000000008143333 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore 0.0024 None 0.0000000000088 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore - - 0.0000000000166 - 26500701_sex_kora_f4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore - - 0.0000000000173 - 26500701_sex_kora_f4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea -0.0018 0.00027 0.000000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0553642 0.00824391 0.00000000001939612 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0549831 0.00824408 0.00000000002660384 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0549724 0.00824409 0.00000000002683912 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg10049775 chr15:65043898 15 65043898 RBPMS2 Open sea -0.1035757 0.0156294 0.00000000003427 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea -0.0544566 0.00824432 0.00000000004102466 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0543947 0.00824435 0.00000000004315558 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0629799 0.00965279 0.00000000007045863 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0535687 0.00824472 0.00000000008439148 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0067 0.00094 0.00000000015 None 33564054_Kashima-K_gestational_age Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg09093388 chr15:65067381 15 65067381 RBPMS2 Island 0.00455 7e-04 0.000000000244 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0520539 0.00824538 0.0000000002813715 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0517204 0.00824552 0.0000000003651578 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.0516285 0.00824556 0.0000000003922377 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0516251 0.00824556 0.0000000003932678 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg05265071 chr15:65032946 15 65032946 RBPMS2 Open sea -0.289872 0.0465702 0.0000000004939441 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea -0.01905 0.00293 0.00000000063 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg10766972 chr15:65058448 15 65058448 RBPMS2 Open sea -0.268732 0.0434879 0.0000000006568526 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 1.9 0.31 0.00000000075 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.050176 0.00824617 0.000000001195637 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0566318 0.00930909 0.000000001205129 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0500263 0.00824623 0.000000001338869 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0500021 0.00824624 0.000000001363551 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0498097 0.00824632 0.000000001576093 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0498033 0.00824633 0.000000001583658 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea -0.06214 0.0103 0.00000000169 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0560951 0.00933724 0.000000001926499 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0018 0.0003 0.0000000023 None 33450751_Mulder-RH_age_sex_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.270446 0.0454882 0.000000002810699 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0486203 0.00824681 0.00000000381402 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0486068 0.00824681 0.000000003851994 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.01186 0.00204 0.000000006 None 33279932_Li-M_schizophrenia_main Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg22159557 chr15:65067668 15 65067668 RBPMS2 Island 1.553651 0.2673 0.00000000614 - 27105112_hiv_infection_discovery Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.024 0.00383 0.0000000069 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0475571 0.00824723 0.00000000825969 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.155752 0.0271144 0.000000009388098 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore - - 0.0000000116 - 26500701_sex_kora_f3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0467951 0.00824753 0.0000000142278 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0467906 0.00832917 0.00000001970639 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20480427 chr15:65033790 15 65033790 RBPMS2 Open sea 0.046236 0.00824774 0.00000002109085 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0462118 0.00824775 0.00000002145171 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0538206 0.00964444 0.00000002441008 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0036 0.00065 0.000000027 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.280135 0.0505721 0.00000003080817 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0456577 0.00824796 0.00000003154229 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0454036 0.00824806 0.00000003758696 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0047 0.00086 0.00000004 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22159557 chr15:65067668 15 65067668 RBPMS2 Island -0.0586647 0.0107406 0.00000004786656 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore -0.0449924 0.00824821 0.00000004981936 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0449121 0.00824824 0.00000005262465 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.0448905 0.00824825 0.00000005340457 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0448651 0.00824826 0.00000005433466 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore 0.01208 0.0022 0.00000006 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10766972 chr15:65058448 15 65058448 RBPMS2 Open sea 0.0446639 0.00824833 0.00000006228843 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0445559 0.00824837 0.00000006701114 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea -0.0443494 0.00824845 0.00000007702807 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.043942 0.0082486 0.0000001012045 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.138965 0.0262207 0.0000001172672 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0422456 0.00801342 0.0000001369638 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore None None 0.00000014 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0902201 0.0171461 0.0000001426 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0430913 0.0082489 0.0000001776093 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05926186 chr15:65042209 15 65042209 RBPMS2 Open sea -0.00059 0.00011 0.00000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0429806 0.00824894 0.000000190952 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0428432 0.00824899 0.0000002088629 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SELL protein levels (SeqId = 4831-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SELL protein levels (SeqId = 4831-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: L-selectin 774 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.62 0.121 0.00000022 None Gadd-DA_sell_protein_levels__seqid___4831-4__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0018 None 0.00000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore -0.0426029 0.00824908 0.0000002441554 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore 0.0422567 0.0082492 0.0000003052874 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0421169 0.00824925 0.000000333976 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0420402 0.00824927 0.0000003507898 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0467637 0.00930263 0.0000005042565 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0412267 0.00824955 0.0000005876433 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0411355 0.00824958 0.0000006222503 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore -0.0410526 0.00824961 0.0000006554487 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0409414 0.00824965 0.0000007026185 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0407911 0.0082497 0.0000007716131 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.133995 0.0272046 0.0000008493802 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.042348 0.00859868 0.0000008530273 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.0406126 0.00824976 0.0000008620322 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0406096 0.00824976 0.0000008636642 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea -0.0404752 0.00824981 0.0000009385113 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20953462 chr15:65040591 15 65040591 RBPMS2 Open sea 0.0402888 0.00824987 0.000001052793 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0402622 0.00824988 0.000001070169 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg05265071 chr15:65032946 15 65032946 RBPMS2 Open sea - - 0.00000112 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.124163 0.0255427 0.000001178067 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0400828 0.00824994 0.000001194626 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FCGR3B protein levels (SeqId = 3311-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCGR3B protein levels (SeqId = 3311-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin gamma Fc region receptor III-B 774 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.584 0.121 0.0000012 None Gadd-DA_fcgr3b_protein_levels__seqid___3311-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0399293 0.00824999 0.000001312153 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0485646 0.0100724 0.000001438713 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0432191 0.00898419 0.000001519922 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0396676 0.00825007 0.000001538463 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.0394781 0.00825013 0.000001725323 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0480733 0.0100692 0.000001821022 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0393389 0.00825018 0.000001876218 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea 0.163038 0.0342803 0.000001990412 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20480427 chr15:65033790 15 65033790 RBPMS2 Open sea 0.0391966 0.00825023 0.000002043561 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0391867 0.00825023 0.000002055796 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0390723 0.00825027 0.000002201443 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0407099 0.00859704 0.000002207351 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0430804 0.00911185 0.000002289037 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0389247 0.00825031 0.000002404074 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0453648 0.00961858 0.000002422963 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore -0.002 0.00042 0.0000026 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0386956 0.00825039 0.000002754523 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0386015 0.00825042 0.000002912312 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0385739 0.00825043 0.00000296011 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0448955 0.00960826 0.000003000578 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0385506 0.00825043 0.000003001283 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore None None 0.0000031 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -1.7 0.36 0.0000032 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore -0.038226 0.00825054 0.000003632288 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.01921 0.00405 0.0000041 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea 0.0379388 0.00825063 0.000004295148 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0428526 0.00932925 0.000004397936 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Battram T ARIES None 2020-08-20 Cholesterol esters to total lipids ratio in very large VLDL EFO_0008589 None None DNA methylation Cholesterol esters to total lipids ratio in very large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 605 1 Adults Females European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0212 0.0046 0.0000044 None Battram-T_cholesterol_esters_to_total_lipids_ratio_in_very_large_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea 0.0378267 0.00825066 0.000004584178 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0395529 0.00863394 0.000004663585 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.037788 0.00825067 0.000004688188 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.294028 0.0644306 0.000005064775 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0440756 0.00965939 0.000005084118 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0376448 0.00825072 0.000005093159 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GJA8 protein levels (SeqId = 12711-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GJA8 protein levels (SeqId = 12711-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gap junction alpha-8 protein 774 1 Adults (18-65 years) Both European cg22040527 chr15:65053596 15 65053596 RBPMS2 Open sea -0.92 0.202 0.0000051 None Gadd-DA_gja8_protein_levels__seqid___12711-19__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore 0.0376612 0.00834349 0.000006415654 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0410788 0.00910507 0.000006482835 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0370908 0.00825089 0.000006997943 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0370507 0.0082509 0.000007159531 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea 0.0370251 0.00825091 0.000007264887 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea 0.0375759 0.0083816 0.000007410824 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea 0.0368949 0.00825095 0.000007822225 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.0369871 0.00829159 0.000008226322 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0367424 0.008251 0.000008527145 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg05926186 chr15:65042209 15 65042209 RBPMS2 Open sea -0.00032 0.000072 0.0000087 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore -0.0365985 0.00825104 0.000009247386 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0365507 0.00825105 0.000009499463 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.003 0.00067 0.0000095 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0364937 0.00825107 0.000009808619 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.02 0.00444 0.0000099 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10766972 chr15:65058448 15 65058448 RBPMS2 Open sea 0.0364508 0.00825108 0.00001004746 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0362972 0.00825113 0.00001094884 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22040527 chr15:65053596 15 65053596 RBPMS2 Open sea 0.0361801 0.00825117 0.00001168755 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0398186 0.00909962 0.00001217969 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0360449 0.00825121 0.00001259948 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.00062102 0.00014222 0.0000139 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.219352 0.0507054 0.00001526893 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.139432 0.0322834 0.00001576209 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea -0.0362849 0.00840481 0.00001590858 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea -0.0354698 0.00825138 0.00001729439 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.0397052 0.00924395 0.00001756044 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0415872 0.00968383 0.00001762162 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0354168 0.00825139 0.00001780295 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.00033 0.000077 0.000018 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea -0.0360458 0.00840684 0.00001817034 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0353708 0.00825141 0.00001825549 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0353048 0.00825142 0.00001892351 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0352778 0.00825143 0.00001920369 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore 0.0354016 0.00828209 0.00001927953 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10766972 chr15:65058448 15 65058448 RBPMS2 Open sea 0.0352659 0.00825144 0.00001932891 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.0352234 0.00825145 0.00001978037 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0351299 0.00825148 0.0000208101 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea 0.0353882 0.00832474 0.00002141642 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg12725420 chr15:65068371 15 65068371 RBPMS2 South shore - - 0.0000221 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0349791 0.00825152 0.00002257811 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0364603 0.00861232 0.00002314755 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.0383751 0.00907674 0.00002373572 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore - - 0.0000243 - 26500701_sex_kora_f3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea -0.0354238 0.00839233 0.000024472 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0393482 0.00933433 0.00002507972 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0347635 0.00825158 0.0000253567 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.034709 0.0082516 0.00002610791 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea -0.034687 0.0082516 0.0000264181 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea -0.0346414 0.00825162 0.00002707142 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea 0.0346315 0.00825162 0.00002721388 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.034623 0.00825162 0.00002733791 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05265071 chr15:65032946 15 65032946 RBPMS2 Open sea -0.0349258 0.00834771 0.00002882566 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 1.5 0.365 0.000029 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0344418 0.00825167 0.00003011349 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0343934 0.00825169 0.00003089897 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00656513 chr15:65064535 15 65064535 RBPMS2 North shelf -0.004 0.00097 0.000031 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0359549 0.00863497 0.00003146857 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0343214 0.00825171 0.00003210243 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22159557 chr15:65067668 15 65067668 RBPMS2 Island -0.00018 0.000044 0.000033 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.188852 0.0454766 0.00003301158 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.037871 0.00912127 0.00003315186 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0342071 0.00825174 0.00003410723 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS6 protein levels (SeqId = 11239-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS6 protein levels (SeqId = 11239-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 6 774 1 Adults (18-65 years) Both European cg22040527 chr15:65053596 15 65053596 RBPMS2 Open sea -0.83 0.199 0.000035 None Gadd-DA_tmprss6_protein_levels__seqid___11239-49__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23221375 chr15:65053605 15 65053605 RBPMS2 Open sea 0.14221 0.0343643 0.00003515349 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg05265071 chr15:65032946 15 65032946 RBPMS2 Open sea -0.199645 0.0482441 0.00003515611 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0340942 0.00825177 0.00003620261 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea -0.0340936 0.00825177 0.00003621376 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0340764 0.00825178 0.00003654349 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0375341 0.00908927 0.00003655716 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea -0.0339527 0.00825181 0.00003900131 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0339501 0.00825181 0.00003905406 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0339231 0.00825182 0.0000396114 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20480427 chr15:65033790 15 65033790 RBPMS2 Open sea 0.0338863 0.00825183 0.00004038334 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.180231 0.0439136 0.0000407553 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22040527 chr15:65053596 15 65053596 RBPMS2 Open sea 0.0343444 0.00838698 0.00004244933 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20480427 chr15:65033790 15 65033790 RBPMS2 Open sea -0.0336783 0.00825189 0.00004502477 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea -0.0380461 0.00933476 0.00004610841 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0335973 0.00825191 0.00004696413 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.966534 0.2375 0.0000472 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0367343 0.00907089 0.00005154923 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.008 0.002 0.0000588 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.033157 0.00825203 0.00005897636 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0364886 0.00910681 0.00006186603 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0364648 0.00910106 0.00006188965 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SEMA4A protein levels (SeqId = 16915-153) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SEMA4A protein levels (SeqId = 16915-153) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Semaphorin-4A 774 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.48 0.12 0.000062 None Gadd-DA_sema4a_protein_levels__seqid___16915-153__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0330808 0.00826093 0.00006245769 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.0334521 0.00837779 0.00006557376 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore -0.0332895 0.00834612 0.00006678217 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg08209769 chr15:65054317 15 65054317 RBPMS2 Open sea -0.0052 0.0013 0.000067 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Antoun E UPBEAT 33151971 2020-11-05 1-hour glucose EFO_0004468 None S1 Data Table E 1-hour glucose DNA methylation Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity None Beta Values Illumina HumanMethylationEPIC Cord blood None 557 1 Infants Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -1.90709 0.47477 0.000068 None 33151971_Antoun-E_1-hour_glucose Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0368533 0.00925178 0.00006827221 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea 0.0328592 0.00825211 0.00006869179 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20710495 chr15:65034489 15 65034489 RBPMS2 Open sea 0.0328239 0.00825212 0.00006994024 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.0330424 0.00830953 0.00007029058 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0361943 0.0091131 0.00007170882 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.258469 0.0651423 0.00007284654 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.0328624 0.00828396 0.00007313393 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore - - 0.0000736 - 26500701_sex_kora_f3 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg00656513 chr15:65064535 15 65064535 RBPMS2 North shelf 0.0022 0.00054 0.000075 None 33564054_Kashima-K_gestational_age Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14076 1 Adults (18-65y) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.03 0.00753 0.000075 None Robert-F-Hillary_Incident_COPD_Fully-adjusted_model Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg19567193 chr15:65066231 15 65066231 RBPMS2 North shore -0.0062 0.0016 0.000075 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island -0.0326822 0.00825216 0.00007516662 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0326806 0.00825216 0.00007522644 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.0326764 0.00825216 0.00007538744 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 D6RF35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation D6RF35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06034792 chr15:65068554 15 65068554 RBPMS2 South shore 0.037873 0.00957026 0.00007613963 D6RF35 41361833_Josephine_Robertson_D6RF35_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore 0.0326189 0.00825218 0.00007761617 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0024 None 0.000078 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0325873 0.00825219 0.00007886682 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17075310 chr15:65047537 15 65047537 RBPMS2 Open sea 0.0325682 0.00825219 0.00007963299 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore 0.0033 0.00083 0.000081 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -0.0105 0.0027 0.000081 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22914902 chr15:65047613 15 65047613 RBPMS2 Open sea 0.0397928 0.0100969 0.00008149395 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.035635 0.00905163 0.0000829374 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11479165 chr15:65068594 15 65068594 RBPMS2 South shore -0.0324713 0.00825222 0.00008363013 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13474370 chr15:65068885 15 65068885 RBPMS2 South shore None None 0.000084 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Antoun E UPBEAT 33151971 2020-11-05 1-hour glucose EFO_0004468 Adjusted for intervention S1 Data Table Q 1-hour glucose DNA methylation Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity,intervention None Beta Values Illumina HumanMethylationEPIC Cord blood None 557 1 Infants Both European cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore -2.1147 0.5335 0.000084 None 33151971_Antoun-E_1-hour_glucose_adjusted_for_intervention Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.0357557 0.0090945 0.00008477821 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Battram T ARIES None 2020-08-20 Head bone mineral density EFO_0007591 None None DNA methylation Head bone mineral density Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g/cm2 Illumina HumanMethylation450 Whole blood DXA scan measurement 706 1 Adults Females European cg01230639 chr15:65032199 15 65032199 RBPMS2 Open sea -0.38 0.096 0.000086 None Battram-T_head_bone_mineral_density Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0364752 0.00929329 0.00008716294 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02658693 chr15:65068326 15 65068326 RBPMS2 Island 0.0323808 0.00825224 0.00008753005 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22423363 chr15:65042722 15 65042722 RBPMS2 Open sea -0.0323674 0.00825225 0.00008812578 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Sharp GC - 28603561 2017-06-08 Cleft palate vs cleft lip EFO_0003959, HP_0000175 - Additional file 5 DNA methylation Cleft palate vs cleft lip Sex and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 98 1 0 Both European,Other cg18210365 chr15:65066710 15 65066710 RBPMS2 North shore 0.05370295 0.01305003 0.0000899 - 28603561_cleft_palate_vs_cleft_lip Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22159557 chr15:65067668 15 65067668 RBPMS2 Island -0.0323079 0.00825226 0.00009079966 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FUT3 protein levels (SeqId = 4548-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FUT3 protein levels (SeqId = 4548-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galactoside 3(4)-L-fucosyltransferase 774 1 Adults (18-65 years) Both European cg22040527 chr15:65053596 15 65053596 RBPMS2 Open sea -0.79 0.202 0.000094 None Gadd-DA_fut3_protein_levels__seqid___4548-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18519993 chr15:65046138 15 65046138 RBPMS2 Open sea 0.0322316 0.00825228 0.00009434235 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20684880 chr15:65053614 15 65053614 RBPMS2 Open sea 0.0321895 0.00825229 0.00009635272 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea -0.035343 0.00906605 0.00009726668 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02718064 chr15:65059529 15 65059529 RBPMS2 Open sea 0.0354638 0.00911105 0.00009969924 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2