author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0031	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0043	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.018	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26680885	chr6:167370215	6	167370215	RNASET2	Island	0.00057	None	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26680885	chr6:167370215	6	167370215	RNASET2	Island	0.0017	None	2.4999999999999997e-251	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.15367	0.0081585	3.227662e-78	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.148837	0.00816461	1.9450970000000002e-73	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.147222	0.0081666	7.090753e-72	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2984884 (gene symbol: RNASET2)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2984884 (gene symbol: RNASET2)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	None	None	2.2e-71	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2984884__gene_symbol__rnaset2__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.26475	0.00948	9.699999999999999e-70	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.136338	0.00817947	8.246126e-62	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.135089	0.00818089	1.046973e-60	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.17358	0.0077	6e-56	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.125198	0.00819161	2.484225e-52	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.12713	0.00613	5.8e-51	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.120026	0.00819688	3.273657e-48	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-	-	9.53e-42	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.103579	0.00821216	2.76528e-36	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.101895	0.0082136	3.652644e-35	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.10162	0.00821383	5.548924999999999e-35	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.10157	0.00821387	5.984709e-35	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.100341	0.0082149	3.812318e-34	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0977504	0.00821703	1.749543e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0948395	0.00821936	1.143702e-30	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0932011	0.00822063	1.1374030000000001e-29	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0930387	0.00822076	1.425121e-29	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-	-	2e-27	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0864411	0.00822567	9.722750999999999e-26	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0864006	0.0082257	1.02438e-25	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.085953	0.00822602	1.820669e-25	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0798516	0.00823021	3.4383990000000003e-22	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0790533	0.00823073	8.856817000000001e-22	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0773838	0.00823181	6.213883e-21	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.042	0.00356	2.3e-20	None	32795589_Kyung-WK_eosinophilia_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14479329	chr6:167370587	6	167370587	RNASET2	Island	0.03924	0.00384	7.4e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.044	0.00389	1.4e-19	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0743297	0.00823373	1.9721229999999998e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0732141	0.00823441	6.737646e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0704306	0.00823607	1.3340310000000001e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0694334	0.00823665	3.7814690000000004e-17	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0680885	0.00823741	1.506092e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0679569	0.00823748	1.72173e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0669179	0.00823806	4.907743e-16	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0655644	0.00823881	0.000000000000001875698	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0655444	0.00823882	0.000000000000001912971	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0651614	0.00823902	0.000000000000002781643	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0646481	0.0082393	0.000000000000004579225	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0645658	0.00823934	0.000000000000004958252	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg02168492	chr6:167356965	6	167356965	RNASET2	Open sea	-0.02	0.00215	0.0000000000000091	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0637415	0.00823978	0.00000000000001094	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0634829	0.00823992	0.00000000000001399488	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2984884 (gene symbol: RNASET2)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2984884 (gene symbol: RNASET2)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	None	None	0.000000000000019	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2984884__gene_symbol__rnaset2__meta-analysis
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg18247054	chr6:167369941	6	167369941	RNASET2	Island	0.00578	8e-04	0.0000000000000193	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0629199	0.00824021	0.00000000000002383904	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0625056	0.00824043	0.00000000000003517665	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg02168492	chr6:167356965	6	167356965	RNASET2	Open sea	-0.016	0.00183	0.000000000000053	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0616068	0.00824089	0.0000000000000811081	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0608717	0.00824126	0.0000000000001592073	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0608553	0.00824127	0.0000000000001616095	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg12722569	chr6:167370648	6	167370648	RNASET2	South shore	2.62684	0.3565	0.000000000000174	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0603959	0.0082415	0.0000000000002453034	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0603928	0.0082415	0.0000000000002460092	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0601235	0.00824163	0.000000000000313723	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.358912	0.0492594	0.0000000000003326383	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0599472	0.00824172	0.0000000000003676635	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.29395	0.0405	0.00000000000041	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0595351	0.00824193	0.0000000000005317946	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0595018	0.00824194	0.0000000000005478656	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0593784	0.008242	0.000000000000611538	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0591618	0.00824211	0.0000000000007413922	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0591218	0.00824213	0.0000000000007681609	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg08742290	chr6:167371091	6	167371091	RNASET2	South shore	-0.027	0.00331	0.0000000000016	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0581184	0.00824262	0.000000000001856147	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.057926	0.00824271	0.000000000002194727	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0574405	0.00824294	0.000000000003341154	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0572312	0.00824304	0.000000000004000461	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	0.0098	0.0014	0.0000000000041	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0570877	0.00824311	0.000000000004524941	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04269497	chr6:167369491	6	167369491	RNASET2	Island	-0.000082	0.000012	0.0000000000057	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0565995	0.00824334	0.000000000006863456	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0561628	0.00824354	0.000000000009934714	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0558477	0.00824369	0.00000000001295014	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0555501	0.00824382	0.00000000001661247	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.0554925	0.00824385	0.00000000001742969	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.107986	0.0162047	0.00000000002761905	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18247054	chr6:167369941	6	167369941	RNASET2	Island	-0.000044	0.0000066	0.000000000049	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0540899	0.00824448	0.00000000005533595	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0540735	0.00824449	0.00000000005607921	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0538518	0.00824459	0.00000000006713522	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0537314	0.00824464	0.00000000007400365	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.105866	0.016256	0.0000000000763564	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0525949	0.00824514	0.0000000001837212	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0525461	0.00824517	0.0000000001909473	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16523675	chr6:167370266	6	167370266	RNASET2	Island	0.00025	0.00004	0.00000000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0522117	0.00824531	0.000000000248573	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05460996	chr6:167370529	6	167370529	RNASET2	Island	-0.00055	0.000087	0.00000000035	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.101422	0.0163146	0.0000000005217491	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.100842	0.0162479	0.0000000005564521	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.00080305	0.0001286	0.000000000613	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0949619	0.0154993	0.0000000009192278	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.0014	0.00022	0.0000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0500726	0.00824621	0.000000001292853	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0499878	0.00824625	0.000000001378293	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	-0.0495019	0.00824645	0.000000001985061	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.14767	0.0247	0.00000000221	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0488898	0.0082467	0.000000003127612	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12722569	chr6:167370648	6	167370648	RNASET2	South shore	0.00035	0.00006	0.0000000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0906143	0.0154657	0.000000004754464	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08742290	chr6:167371091	6	167371091	RNASET2	South shore	0.0479985	0.00824706	0.000000006004986	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.279973	0.0482639	0.000000006711984	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0478283	0.00824712	0.000000006792825	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0900656	0.0156887	0.000000009610131	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0885455	0.0154272	0.000000009679121	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0470348	0.00824743	0.00000001200126	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04269497	chr6:167369491	6	167369491	RNASET2	Island	0.00543	0.00091	0.000000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18543192	chr6:167370845	6	167370845	RNASET2	South shore	0.0464718	0.00824765	0.00000001787408	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0459773	0.00824784	0.0000000252664	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0458938	0.00824787	0.00000002677832	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0455286	0.00824801	0.000000034484	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0453767	0.00824807	0.00000003828856	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0857975	0.0156571	0.0000000432907	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0450582	0.00824819	0.00000004763297	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.91	0.166	0.000000048	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0468615	0.00858742	0.00000004921307	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0449863	0.00824821	0.00000005002885	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0448985	0.00824825	0.00000005311437	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0446073	0.00824835	0.00000006472342	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0049	0.00091	0.000000065	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0445271	0.00824838	0.00000006832845	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	-0.0565314	0.0105023	0.00000007447538	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.265803	0.0494066	0.00000007549555	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0443789	0.00824844	0.00000007551194	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0442911	0.00824847	0.00000008010949	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0442577	0.00824848	0.0000000819274	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0814471	0.0154247	0.0000001308071	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0824682	0.0157206	0.0000001577037	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14479329	chr6:167370587	6	167370587	RNASET2	Island	0.007	0.0014	0.00000021	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0428053	0.008249	0.0000002140818	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0425978	0.00824908	0.000000244959	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.246901	0.0480774	0.0000002842971	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.0423659	0.00824916	0.0000002845698	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0801546	0.0156108	0.0000002864084	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0421954	0.00824922	0.0000003175562	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0822165	0.0161084	0.0000003367897	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.129656	0.0254105	0.0000003386363	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0420645	0.00824926	0.0000003453718	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0420643	0.00824926	0.0000003454193	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18205030	chr6:167354268	6	167354268	RNASET2	Open sea	0.0419554	0.0082493	0.0000003703234	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0418066	0.00824935	0.0000004072099	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	-0.0527842	0.0104332	0.000000425956	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CHGB protein levels (SeqId = 8235-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHGB protein levels (SeqId = 8235-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Secretogranin-1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.88	0.175	0.00000046	None	Gadd-DA_chgb_protein_levels__seqid___8235-48__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0415404	0.00824944	0.0000004821463	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0414887	0.00824946	0.0000004981946	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0413923	0.0082495	0.0000005294609	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0777709	0.0156099	0.0000006359457	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0782948	0.0157169	0.0000006378566	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.041059	0.00824961	0.000000652794	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0410273	0.00824962	0.0000006658766	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0410077	0.00824963	0.0000006740863	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18205030	chr6:167354268	6	167354268	RNASET2	Open sea	0.0409454	0.00824965	0.0000007008653	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0425301	0.00859566	0.0000007586817	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0404846	0.0082498	0.0000009331127	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0403975	0.00824983	0.0000009846373	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.076048	0.0155324	0.000000988087	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0417579	0.00855725	0.000001072918	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0400884	0.00824993	0.000001190537	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0400039	0.00824996	0.000001253721	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0399831	0.00824997	0.000001269696	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0748763	0.0155099	0.000001395469	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Cronjé HT	Prospective Urban and Rural Epidemiology study	31910897	2020-01-07	Alcohol consumption	EFO_0004329, NCIT_C16273	None	Additional file 2a	DNA methylation	Alcohol consumption	Age, body mass index, smoking, cell composition (reference based), batch effects	Beta Values	grams per day	Illumina HumanMethylationEPIC	Whole blood	None	108	1	Adults	Males	African	cg18205030	chr6:167354268	6	167354268	RNASET2	Open sea	-0.00087	0.00016	0.0000014	None	31910897_Cronjé-HT_alcohol_consumption
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18543192	chr6:167370845	6	167370845	RNASET2	South shore	0.0397809	0.00825004	0.000001436159	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0395911	0.0082501	0.000001611374	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0394274	0.00825015	0.000001778895	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0778997	0.0163235	0.000001839333	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0763065	0.0160296	0.000001950992	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0771063	0.016215	0.000002000823	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0392101	0.00825022	0.000002027168	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.074265	0.0156943	0.000002244232	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0390142	0.00825029	0.00000227925	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NMB protein levels (SeqId = 9321-400)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMB protein levels (SeqId = 9321-400)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuromedin-B	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.826	0.175	0.0000024	None	Gadd-DA_nmb_protein_levels__seqid___9321-400__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.085973	0.0182483	0.00000248421	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SPINK1 protein levels (SeqId = 8243-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPINK1 protein levels (SeqId = 8243-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine protease inhibitor Kazal-type 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.82	0.175	0.0000026	None	Gadd-DA_spink1_protein_levels__seqid___8243-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0387489	0.00825037	0.000002668871	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0386978	0.00825039	0.000002751017	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0386624	0.0082504	0.000002809284	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0734215	0.0156783	0.000002852442	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0731941	0.0156373	0.00000288382	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0385312	0.00825044	0.00000303568	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0383917	0.00825048	0.000003295718	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16523675	chr6:167370266	6	167370266	RNASET2	Island	0.00697	0.00146	0.0000034	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0382367	0.00825053	0.000003609645	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0382293	0.00825054	0.000003625328	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0741999	0.0160467	0.000003796561	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0725787	0.0156972	0.000003802273	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Hernandez-Vargas H	-	25855716	2015-04-07	Prenatal exposure to aflatoxin B1	CHEBI_2504	-	Table 2	DNA methylation	Prenatal exposure to aflatoxin B1	Sex, season of conception and technical covariates	M values	-	Illumina HumanMethylation450	White blood cells	-	115	1	0.3	Both	African	cg26680885	chr6:167370215	6	167370215	RNASET2	Island	-	-	0.000004	-	25855716_prenatal_exposure_to_aflatoxin_b1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0380424	0.00825059	0.000004043844	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04745296	chr6:167346571	6	167346571	RNASET2	Open sea	-0.200135	0.0434176	0.000004063046	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0379463	0.00825062	0.000004276448	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.0626	0.01314	0.0000047	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Gadd DA	Generation Scotland	35945220	31/07/2022	PLTP protein levels (SeqId = 15475-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLTP protein levels (SeqId = 15475-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phospholipid transfer protein	774	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.89	0.194	0.0000048	None	Gadd-DA_pltp_protein_levels__seqid___15475-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0377425	0.00825069	0.000004813384	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0377175	0.0082507	0.000004883709	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0743623	0.0162673	0.000004887429	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0376473	0.00825072	0.000005085866	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.083688	0.0183422	0.000005093387	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0376005	0.00825073	0.000005225055	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0389815	0.00855952	0.000005301754	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0375516	0.00825075	0.000005374577	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0710224	0.015631	0.000005572108	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TBP protein levels (SeqId = 2875-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBP protein levels (SeqId = 2875-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: TATA-box-binding protein	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.79	0.175	0.0000057	None	Gadd-DA_tbp_protein_levels__seqid___2875-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0374089	0.00825079	0.00000583429	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.212956	0.0470263	0.000005979591	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.01	0.0022	0.0000062	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0373023	0.00825083	0.000006201715	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0371721	0.00825087	0.000006681028	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0371468	0.00825087	0.000006778335	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0544663	0.0121056	0.000006871327	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.038625	0.00858872	0.000006938812	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0370283	0.00825091	0.000007251746	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0370176	0.00825091	0.000007295652	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13692156	chr6:167365617	6	167365617	RNASET2	North shelf	0.0379928	0.00847009	0.000007328722	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0369884	0.00825092	0.000007417997	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0723642	0.0161986	0.000007979787	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0368015	0.00825098	0.000008247088	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0697159	0.015636	0.000008307746	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0696827	0.0157066	0.0000092083	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0720936	0.0162846	0.000009619614	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0365248	0.00825106	0.000009638869	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0541424	0.0122507	0.000009961768	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PTK7 protein levels (SeqId = 9525-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTK7 protein levels (SeqId = 9525-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inactive tyrosine-protein kinase 7	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.77	0.175	0.00001	None	Gadd-DA_ptk7_protein_levels__seqid___9525-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0364337	0.00825109	0.00001014402	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0013	None	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18247054	chr6:167369941	6	167369941	RNASET2	Island	0.00211	0.00047	0.000011	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.02	0.00456	0.000011	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0377774	0.00859785	0.00001121557	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0362295	0.00825115	0.00001136999	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.157966	0.0360036	0.0000115331	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	MAP2K4 protein levels (SeqId = 5242-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAP2K4 protein levels (SeqId = 5242-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dual specificity mitogen-activated protein kinase kinase 4	774	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.73	0.167	0.000012	None	Gadd-DA_map2k4_protein_levels__seqid___5242-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0686892	0.0157129	0.00001242348	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	HLA-DQA2 protein levels (SeqId = 7757-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HLA-DQA2 protein levels (SeqId = 7757-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: HLA class II histocompatibility antigen, DQ alpha 2 chain	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.76	0.175	0.000013	None	Gadd-DA_hla-dqa2_protein_levels__seqid___7757-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0359774	0.00825123	0.00001308023	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0522192	0.0120116	0.0000138681	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.068142	0.0156743	0.00001387026	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0358585	0.00825126	0.00001396923	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg13692156	chr6:167365617	6	167365617	RNASET2	North shelf	0.91	0.209	0.000014	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0358354	0.00825127	0.00001414833	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	-0.0358131	0.00825127	0.0000143233	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0357677	0.00825129	0.00001468614	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12722569	chr6:167370648	6	167370648	RNASET2	South shore	0.0017	0.00039	0.000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.035653	0.00825132	0.00001564301	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CD109 protein levels (SeqId = 3290-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD109 protein levels (SeqId = 3290-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD109 antigen	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.75	0.175	0.000016	None	Gadd-DA_cd109_protein_levels__seqid___3290-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0355683	0.00825135	0.00001638741	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0355612	0.00825135	0.00001645107	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0676119	0.0157179	0.00001706899	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08636390	chr6:167347801	6	167347801	RNASET2	Open sea	-0.0354737	0.00825137	0.00001725829	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0354245	0.00825139	0.00001772787	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IL27 protein levels (SeqId = 2829-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL27 protein levels (SeqId = 2829-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-27 subunit beta|Interleukin-27 subunit alpha	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.751	0.175	0.000018	None	Gadd-DA_il27_protein_levels__seqid___2829-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RSPO3 protein levels (SeqId = 13094-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RSPO3 protein levels (SeqId = 13094-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: R-spondin-3	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.75	0.175	0.000018	None	Gadd-DA_rspo3_protein_levels__seqid___13094-75__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.207541	0.0483957	0.00001809229	None	39706196_Hannah-M.-Smith_body_fat_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18261144	chr6:167370276	6	167370276	RNASET2	Island	-0.00005	0.000012	0.00002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0696653	0.0163362	0.00002016402	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.024	0.00563	0.000021	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0695464	0.016347	0.00002109305	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.0350668	0.00825149	0.00002153301	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.111073	0.0261429	0.00002161377	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0349923	0.00825152	0.00002241727	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0692733	0.0163563	0.00002296697	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0348994	0.00825154	0.00002356967	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0348864	0.00825155	0.00002373463	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	C19orf18 protein levels (SeqId = 9445-44)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C19orf18 protein levels (SeqId = 9445-44)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C19orf18	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.74	0.175	0.000024	None	Gadd-DA_c19orf18_protein_levels__seqid___9445-44__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0348476	0.00825156	0.00002423553	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.0348379	0.00825156	0.00002436247	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0348337	0.00825156	0.00002441741	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0347925	0.00825157	0.00002496501	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PTPRJ protein levels (SeqId = 8250-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTPRJ protein levels (SeqId = 8250-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Receptor-type tyrosine-protein phosphatase eta	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.74	0.175	0.000025	None	Gadd-DA_ptprj_protein_levels__seqid___8250-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SNPH protein levels (SeqId = 17343-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SNPH protein levels (SeqId = 17343-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntaphilin	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.73	0.174	0.000026	None	Gadd-DA_snph_protein_levels__seqid___17343-6__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05294163	chr6:167346180	6	167346180	RNASET2	Open sea	-0.145445	0.0345912	0.00002626988	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.150882	0.0360334	0.00002837083	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.034549	0.00825164	0.00002844127	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.0345053	0.00825165	0.00002911119	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.109554	0.0262031	0.00002917323	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0652517	0.015658	0.00003099696	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	NRXN1 protein levels (SeqId = 5110-84)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NRXN1 protein levels (SeqId = 5110-84)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurexin-1-beta	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.73	0.175	0.000031	None	Gadd-DA_nrxn1_protein_levels__seqid___5110-84__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0678148	0.0162874	0.00003149984	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0343378	0.0082517	0.00003182519	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	0.0669911	0.0161319	0.00003304272	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18205030	chr6:167354268	6	167354268	RNASET2	Open sea	-0.0342657	0.00825172	0.0000330656	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0672531	0.0162448	0.00003492959	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0341067	0.00825177	0.00003596435	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DSCAML1 protein levels (SeqId = 18886-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSCAML1 protein levels (SeqId = 18886-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Down syndrome cell adhesion molecule-like protein 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.72	0.175	0.000038	None	Gadd-DA_dscaml1_protein_levels__seqid___18886-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0644133	0.0156598	0.00003921877	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0339176	0.00825182	0.00003972647	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	B4GALNT1 protein levels (SeqId = 8976-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B4GALNT1 protein levels (SeqId = 8976-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,4 N-acetylgalactosaminyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.72	0.175	0.00004	None	Gadd-DA_b4galnt1_protein_levels__seqid___8976-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0501226	0.0122186	0.00004115271	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	FSTL1 protein levels (SeqId = 13112-179)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FSTL1 protein levels (SeqId = 13112-179)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Follistatin-related protein 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.72	0.175	0.000042	None	Gadd-DA_fstl1_protein_levels__seqid___13112-179__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.0349251	0.00853399	0.00004290819	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	LSAMP protein levels (SeqId = 2999-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LSAMP protein levels (SeqId = 2999-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Limbic system-associated membrane protein	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.72	0.175	0.000043	None	Gadd-DA_lsamp_protein_levels__seqid___2999-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18543192	chr6:167370845	6	167370845	RNASET2	South shore	0.0337299	0.00825187	0.00004382773	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LAMC2 protein levels (SeqId = 9580-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAMC2 protein levels (SeqId = 9580-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Laminin subunit gamma-2	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.71	0.175	0.000044	None	Gadd-DA_lamc2_protein_levels__seqid___9580-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASET2 protein levels (SeqId = 16913-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASET2 protein levels (SeqId = 16913-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonuclease T2	774	1	Adults (18-65 years)	Both	European	cg08742290	chr6:167371091	6	167371091	RNASET2	South shore	-0.335	0.082	0.000045	None	Gadd-DA_rnaset2_protein_levels__seqid___16913-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0336535	0.00825189	0.00004561157	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0336289	0.0082519	0.00004619847	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.033628	0.0082519	0.00004621957	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-1.4	0.349	0.000048	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SPEF1 protein levels (SeqId = 12876-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPEF1 protein levels (SeqId = 12876-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sperm flagellar protein 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.71	0.174	0.00005	None	Gadd-DA_spef1_protein_levels__seqid___12876-39__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0334493	0.00825195	0.00005071681	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.0334288	0.00825196	0.00005125847	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM132B protein levels (SeqId = 8890-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM132B protein levels (SeqId = 8890-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 132B	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.71	0.175	0.000052	None	Gadd-DA_tmem132b_protein_levels__seqid___8890-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24398081	chr6:167344767	6	167344767	RNASET2	Open sea	0.0333966	0.00825197	0.0000521189	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EDN2 protein levels (SeqId = 12574-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EDN2 protein levels (SeqId = 12574-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Endothelin-2	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.71	0.18	0.000053	None	Gadd-DA_edn2_protein_levels__seqid___12574-36__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MSN protein levels (SeqId = 5009-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MSN protein levels (SeqId = 5009-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Moesin	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000054	None	Gadd-DA_msn_protein_levels__seqid___5009-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-1.01	0.25	0.000054	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GDF15 protein levels (SeqId = 4374-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GDF15 protein levels (SeqId = 4374-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Growth/differentiation factor 15	774	1	Adults (18-65 years)	Both	European	cg16398154	chr6:167369676	6	167369676	RNASET2	Island	0.63	0.157	0.000056	None	Gadd-DA_gdf15_protein_levels__seqid___4374-45__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	-0.034614	0.00859241	0.00005643117	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	-0.0332248	0.00825201	0.00005695413	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	VWA1 protein levels (SeqId = 6385-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VWA1 protein levels (SeqId = 6385-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: von Willebrand factor A domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000057	None	Gadd-DA_vwa1_protein_levels__seqid___6385-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0332115	0.00825202	0.00005734658	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0648736	0.0161376	0.00005848153	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0630916	0.0156964	0.00005861177	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0331158	0.00825204	0.00006023772	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINB1 protein levels (SeqId = 10737-96)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINB1 protein levels (SeqId = 10737-96)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte elastase inhibitor	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.18	0.000061	None	Gadd-DA_serpinb1_protein_levels__seqid___10737-96__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0330806	0.00825205	0.0000613377	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KLF4 protein levels (SeqId = 17850-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLF4 protein levels (SeqId = 17850-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Krueppel-like factor 4	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000062	None	Gadd-DA_klf4_protein_levels__seqid___17850-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TEAD3 protein levels (SeqId = 12854-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TEAD3 protein levels (SeqId = 12854-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcriptional enhancer factor TEF-5	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000062	None	Gadd-DA_tead3_protein_levels__seqid___12854-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0719037	0.0180139	0.00006595919	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	NPDC1 protein levels (SeqId = 10424-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPDC1 protein levels (SeqId = 10424-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neural proliferation differentiation and control protein 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000066	None	Gadd-DA_npdc1_protein_levels__seqid___10424-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13692156	chr6:167365617	6	167365617	RNASET2	North shelf	-0.0328913	0.0082521	0.00006757681	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25258033	chr6:167368657	6	167368657	RNASET2	North shore	0.0328805	0.00825211	0.00006794922	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13692156	chr6:167365617	6	167365617	RNASET2	North shelf	0.0328767	0.00825211	0.00006808141	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB3 protein levels (SeqId = 9220-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB3 protein levels (SeqId = 9220-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 3	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.7	0.175	0.000071	None	Gadd-DA_ephb3_protein_levels__seqid___9220-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01674658	chr6:167370831	6	167370831	RNASET2	South shore	0.032777	0.00825214	0.00007163128	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08742290	chr6:167371091	6	167371091	RNASET2	South shore	0.0327591	0.00825214	0.00007228644	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.0327508	0.00825214	0.00007259112	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IGF1 protein levels (SeqId = 8406-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGF1 protein levels (SeqId = 8406-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor I	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.69	0.175	0.000073	None	Gadd-DA_igf1_protein_levels__seqid___8406-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.047666	0.0120218	0.00007375432	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	XCL1 protein levels (SeqId = 4143-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	XCL1 protein levels (SeqId = 4143-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotactin	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.69	0.175	0.000074	None	Gadd-DA_xcl1_protein_levels__seqid___4143-74__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0474696	0.0119883	0.00007541257	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	-0.0326535	0.00825217	0.00007626749	P00748	41361833_Josephine_Robertson_P00748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11815910	chr6:167366826	6	167366826	RNASET2	North shelf	0.0326212	0.00825218	0.00007752557	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CYB5D2 protein levels (SeqId = 10924-258)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CYB5D2 protein levels (SeqId = 10924-258)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuferricin	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.688	0.174	0.000079	None	Gadd-DA_cyb5d2_protein_levels__seqid___10924-258__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13456812	chr6:167369504	6	167369504	RNASET2	Island	0.130332	0.0330141	0.00007918123	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.061819	0.0156803	0.00008102598	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0325185	0.0082522	0.00008166035	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EFCAB14 protein levels (SeqId = 10830-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFCAB14 protein levels (SeqId = 10830-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: EF-hand calcium-binding domain-containing protein 14	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.69	0.175	0.000082	None	Gadd-DA_efcab14_protein_levels__seqid___10830-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NPFF protein levels (SeqId = 5617-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPFF protein levels (SeqId = 5617-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pro-FMRFamide-related neuropeptide FF	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.689	0.175	0.000083	None	Gadd-DA_npff_protein_levels__seqid___5617-41__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	-0.0324703	0.00825222	0.00008367097	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	0.0324668	0.00825222	0.00008382018	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13456812	chr6:167369504	6	167369504	RNASET2	Island	0.00019	0.000049	0.000084	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.00042	0.00011	0.000086	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Gadd DA	Generation Scotland	35945220	31/07/2022	C1QTNF5 protein levels (SeqId = 7810-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1QTNF5 protein levels (SeqId = 7810-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C1q tumor necrosis factor-related protein 5	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.69	0.175	0.000086	None	Gadd-DA_c1qtnf5_protein_levels__seqid___7810-20__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17991206	chr6:167366683	6	167366683	RNASET2	North shelf	0.138426	0.0352683	0.00008708657	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24069928	chr6:167366776	6	167366776	RNASET2	North shelf	0.0323348	0.00825225	0.00008957889	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg14479329	chr6:167370587	6	167370587	RNASET2	Island	0.814297	0.2079	0.0000896	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12722569	chr6:167370648	6	167370648	RNASET2	South shore	-0.0318634	0.00813641	0.0000903828	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD200 protein levels (SeqId = 5112-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD200 protein levels (SeqId = 5112-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: OX-2 membrane glycoprotein	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.68	0.175	0.000091	None	Gadd-DA_cd200_protein_levels__seqid___5112-73__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	-0.0613177	0.015691	0.00009354998	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	NBL1 protein levels (SeqId = 2944-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NBL1 protein levels (SeqId = 2944-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuroblastoma suppressor of tumorigenicity 1	774	1	Adults (18-65 years)	Both	European	cg18826441	chr6:167358034	6	167358034	RNASET2	Open sea	-0.68	0.175	0.000094	None	Gadd-DA_nbl1_protein_levels__seqid___2944-66__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11301670	chr6:167363345	6	167363345	RNASET2	Open sea	-0.0322228	0.00825228	0.00009476197	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08507135	chr6:167356786	6	167356786	RNASET2	Open sea	0.108865	0.0278823	0.0000947847	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.97	0.25	0.000095	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.0596929	0.015296	0.00009562386	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0634693	0.0162827	0.00009743676	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24885369	chr6:167364028	6	167364028	RNASET2	Open sea	-0.0634919	0.0163093	0.00009945791	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10063403	chr6:167364065	6	167364065	RNASET2	Open sea	0.03212	0.00825231	0.00009976031	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1