author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05473387 chr3:47485244 3 47485244 SCAP Open sea -0.0019 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06318592 chr3:47517621 3 47517621 SCAP Island -0.00014 0.000013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11704818 chr3:47517781 3 47517781 SCAP South shore -0.0047 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0023 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore -0.00061 0.000058 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20950754 chr3:47517690 3 47517690 SCAP South shore -0.00043 0.000044 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22157823 chr3:47517263 3 47517263 SCAP Island 0.0015 None 0 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22157823 chr3:47517263 3 47517263 SCAP Island 0.00049 None 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf -0.0021 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.011 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore 0.022 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0083 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore 0.018 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20560906 chr3:47459876 3 47459876 SCAP Island 0.00045 None 3.2e-204 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05473387 chr3:47485244 3 47485244 SCAP Open sea 0.68154 0.00837 2e-151 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf 0.28684 0.00414 3e-138 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18667319 chr3:47458823 3 47458823 SCAP North shore 0.24189 0.0037 1.2e-133 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore 0.16446 0.00319 9.8e-115 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore - - 1.76e-105 - 28056824_age_4_vs_age_0 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore - - 3.58e-93 - 28056824_age_4_vs_age_0 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24383480 chr3:47466266 3 47466266 SCAP Open sea 0.10832 0.00292 1e-89 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24051786 chr3:47514673 3 47514673 SCAP North shelf 0.29033 0.00789 3.7000000000000004e-89 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.158604 0.00815206 2.911486e-83 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.1285 0.00385 4.5e-82 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.142184 0.00817269 4.063068e-67 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.08983 0.00337 1.2e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg21581415 chr3:47460784 3 47460784 SCAP South shore 3.05441 0.06926 2.6099999999999997e-61 - 25282492_fetal_vs_adult_liver Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11704818 chr3:47517781 3 47517781 SCAP South shore -0.11988 0.00528 1.9999999999999999e-56 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg24383480 chr3:47466266 3 47466266 SCAP Open sea 3.09344 0.09405 7.39e-51 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.122869 0.00819401 1.871002e-50 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg24051786 chr3:47514673 3 47514673 SCAP North shelf - - 1.91e-50 - 23526956_clear_cell_renal_carcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore 0.00066 None 3.1e-50 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14700577 chr3:47517001 3 47517001 SCAP Island 0.07052 0.00346 5.3e-50 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20560906 chr3:47459876 3 47459876 SCAP Island 0.0013 None 2.7e-49 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.117427 0.00819945 3.301268e-46 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg24574902 chr3:47455785 3 47455785 SCAP North shelf 1.88256 0.06743 3.4e-45 - 25282492_fetal_vs_adult_liver Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11704818 chr3:47517781 3 47517781 SCAP South shore - - 6.13e-42 - 23526956_clear_cell_renal_carcinoma Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg24051786 chr3:47514673 3 47514673 SCAP North shelf 2.21362 0.09104 1.47e-40 - 25282492_fetal_vs_adult_liver Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 Monocytes Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values years Illumina HumanMethylation450 Monocytes - 1264 1 60 Both European,African,Admixed cg26614073 chr3:47517819 3 47517819 SCAP South shore - - 3.59e-39 - 25404168_age_monocytes Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg05473387 chr3:47485244 3 47485244 SCAP Open sea 2.3626 0.10501 5e-38 - 25282492_fetal_vs_adult_liver Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg27386529 chr3:47517807 3 47517807 SCAP South shore 2.86623 0.13141 5.0000000000000005e-37 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.103461 0.00821226 3.318788e-36 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg26614073 chr3:47517819 3 47517819 SCAP South shore 2.98669 0.14763 1.19e-34 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0926861 0.00822103 2.3219990000000002e-29 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0894117 0.0082235 1.978903e-27 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.734985 0.0692508 3.110451e-26 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0856655 0.00822622 2.630363e-25 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Witt S None 32080920 02-02-2020 alcohol withdrawal recovery None discovery Table S1 DNA methylation alcohol withdrawal recovery Age, Smoking, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylationEPIC whole blood two weeks after vs active withdrawal 99 1 Adults Males European cg21581415 chr3:47460784 3 47460784 SCAP South shore 5.1 0.361 2.8e-25 None 32080920_Witt-S_alcohol_withdrawal_recovery_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0842769 0.0082272 1.5279279999999999e-24 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0836031 0.00822767 3.551687e-24 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05473387 chr3:47485244 3 47485244 SCAP Open sea 0.0013 None 3.599999999999999e-24 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0828016 0.00822822 9.600661e-24 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.663446 0.067755 1.387775e-22 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0796774 0.00823032 4.230051e-22 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.659798 0.0697462 3.466049e-21 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0764932 0.00823238 1.727584e-20 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20950754 chr3:47517690 3 47517690 SCAP South shore 0.01479 0.00143 2.8e-20 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0741641 0.00823383 2.369572e-19 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0733669 0.00823432 5.7008359999999995e-19 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0732317 0.0082344 6.609290999999999e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0727866 0.00823467 1.0736900000000002e-18 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2672712 (gene symbol: SCAP) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2672712 (gene symbol: SCAP) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg15561453 chr3:47459664 3 47459664 SCAP Island None None 1.4e-18 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2672712__gene_symbol__scap__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore 0.0019 None 1.6e-17 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.069917 0.00823637 2.2854650000000002e-17 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0688713 0.00823697 6.75905e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0688553 0.00823698 6.871339e-17 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0686769 0.00823708 8.25374e-17 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0685836 0.00823713 9.082586000000001e-17 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0012 0.00014 1.1e-16 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0959093 0.0115602 1.164689e-16 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.111527 0.0136154 2.797397e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06333135 chr3:47460006 3 47460006 SCAP Island 0.02012 0.00225 3.4e-16 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0942377 0.011599 4.84159e-16 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0142 0.00177059 5.29e-16 - 28811542_age Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06293180 chr3:47458750 3 47458750 SCAP North shore 0.0177 0.00202 9.1e-16 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.542347 0.0678896 0.000000000000001449302 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0657122 0.00823873 0.000000000000001622466 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0652375 0.00823898 0.000000000000002582618 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0642735 0.0082395 0.000000000000006572252 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0631719 0.00824008 0.00000000000001879279 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0631218 0.00824011 0.00000000000001970562 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14700577 chr3:47517001 3 47517001 SCAP Island 0.00068 0.00009 0.000000000000046 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg00190319 chr3:47462780 3 47462780 SCAP South shelf 0.01964 0.0026 0.0000000000000561 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0615858 0.0082409 0.00000000000008269189 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0612296 0.00824108 0.0000000000001147581 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06333135 chr3:47460006 3 47460006 SCAP Island 0.0011 None 0.00000000000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0609988 0.0082412 0.0000000000001417563 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0607299 0.00824133 0.0000000000001811588 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0607162 0.00824134 0.0000000000001834406 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0604301 0.00824148 0.000000000000237833 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0601807 0.00824161 0.0000000000002979631 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14784617 chr3:47517624 3 47517624 SCAP Island 0.00027 0.000037 0.00000000000041 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0594794 0.00824195 0.0000000000005589389 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg15665967 chr3:47459257 3 47459257 SCAP North shore -1.81699 0.2538 0.00000000000081 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0012 0.00017 0.0000000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0585849 0.00824239 0.000000000001233836 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0585516 0.00824241 0.000000000001270503 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0579517 0.0082427 0.000000000002146193 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.480101 0.0683583 0.000000000002247615 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg02020985 chr3:47475621 3 47475621 SCAP Open sea 0.031 0.00387 0.0000000000031 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0574638 0.00824293 0.000000000003274565 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.0573077 0.008243 0.000000000003746056 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.468974 0.0680716 0.000000000005785261 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf 0.456664 0.0664287 0.000000000006422723 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16586182 chr3:47516702 3 47516702 SCAP North shore -0.0015 0.00022 0.0000000000073 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0556546 0.00824377 0.000000000015223 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0556512 0.00824378 0.00000000001526677 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0556391 0.00824378 0.00000000001542177 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01021385 chr3:47517504 3 47517504 SCAP Island -0.00005 0.0000075 0.000000000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.377269 0.0563212 0.00000000002170179 None 39706196_Hannah-M.-Smith_bmi_sensitivity Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14528821 chr3:47517500 3 47517500 SCAP Island 0.00531 0.00075 0.00000000003 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.00095 0.00014 0.000000000034 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.346215 0.0523066 0.0000000000372359 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0544907 0.0082443 0.00000000003989419 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0544135 0.00824434 0.0000000000424965 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0904133 0.0138463 0.00000000006803238 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0533208 0.00824483 0.0000000001030085 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0532793 0.00824484 0.0000000001064928 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.439137 0.0681252 0.0000000001178601 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05473387 chr3:47485244 3 47485244 SCAP Open sea 0.0041 None 0.00000000012 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0529223 0.008245 0.0000000001416558 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Alvizi L - 28550290 2017-05-26 Non-syndromic cleft lip and palate EFO_0003959, HP_0000175 Discovery Table S1 Non-syndromic cleft lip and palate DNA methylation Age, sex, cell counts and technical covariates - Beta values Illumina HumanMethylation450 Whole blood - 126 1 6 Both European,Other cg01374398 chr3:47516975 3 47516975 SCAP North shore - - 0.000000000186 - 28550290_nonsyndromic_cleft_lip_and_palate_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0525464 0.00824516 0.0000000001909022 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0524368 0.00824521 0.0000000002081772 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.052373 0.00824524 0.0000000002189364 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0523249 0.00824526 0.000000000227394 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0522581 0.00824529 0.0000000002396769 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0522146 0.00824531 0.0000000002480096 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0521479 0.00824534 0.0000000002613684 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0520563 0.00824538 0.0000000002808299 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg01374398 chr3:47516975 3 47516975 SCAP North shore 0.02559 0.0041 0.000000000325 - 23334450_rheumatoid_arthritis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore 0.03274 0.00495 0.00000000036 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0514862 0.00824562 0.0000000004380707 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0514434 0.00824564 0.0000000004528772 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11704818 chr3:47517781 3 47517781 SCAP South shore 0.0093 0.0015 0.00000000059 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0510774 0.00824579 0.000000000600847 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0505598 0.00824601 0.0000000008932957 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.426601 0.0695969 0.0000000009001253 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.0504879 0.00824604 0.0000000009435638 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21412001 chr3:47517510 3 47517510 SCAP Island -0.000071 0.000012 0.0000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0500195 0.00824624 0.000000001345795 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0495378 0.00824643 0.000000001932474 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02020985 chr3:47475621 3 47475621 SCAP Open sea -0.302382 0.0504469 0.000000002085074 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.00019881 3.34e-05 0.00000000261 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.048767 0.00824675 0.00000000342382 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0487605 0.00824675 0.00000000344046 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0486278 0.0082468 0.000000003793158 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0485316 0.00824684 0.000000004070606 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0483754 0.0082469 0.00000000456376 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg26614073 chr3:47517819 3 47517819 SCAP South shore None None 0.0000000049 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.322377 0.0551186 0.000000005036746 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.329685 0.0567044 0.000000006203834 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06333135 chr3:47460006 3 47460006 SCAP Island 0.0036 None 0.0000000068 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0476976 0.00824717 0.000000007464779 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0469688 0.00824746 0.00000001257821 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0469493 0.00824747 0.00000001275332 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.046885 0.00824749 0.00000001334908 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0466968 0.00824756 0.00000001525198 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0466816 0.00824757 0.000000015417 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.046613 0.0082476 0.00000001618145 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0464002 0.00824768 0.00000001879774 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.192537 0.0342645 0.00000001948793 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0462317 0.00824774 0.0000000211546 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0460996 0.00824779 0.00000002320215 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.00759 0.00136 0.000000026 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 T cells Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values Years Illumina HumanMethylation450 T cells - 227 1 - Missing None cg26614073 chr3:47517819 3 47517819 SCAP South shore - - 0.0000000274 - 25404168_age_t_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0457025 0.00824794 0.00000003057853 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0454856 0.00824803 0.00000003552337 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.0451814 0.00824814 0.00000004378027 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0450796 0.00824818 0.00000004694111 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0449526 0.00824823 0.00000005118979 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0448471 0.00824826 0.00000005500328 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0446826 0.00824833 0.00000006150253 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0446243 0.00824835 0.00000006398299 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0445576 0.00824837 0.00000006693231 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0444852 0.0082484 0.00000007028862 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.062596 0.011609 0.00000007074282 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg16119619 chr3:47484491 3 47484491 SCAP Open sea -0.1556804 0.0292665 0.0000001041 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0437121 0.00824868 0.0000001179392 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0737784 0.0139236 0.0000001182514 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0555632 0.0105056 0.0000001247993 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0436216 0.00824871 0.0000001252325 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.277323 0.0524503 0.0000001256096 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.0434109 0.00824879 0.0000001439514 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0611938 0.011634 0.0000001461576 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0613391 0.011668 0.0000001484413 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg26614073 chr3:47517819 3 47517819 SCAP South shore None None 0.00000017 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0430346 0.00824892 0.0000001843226 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0429843 0.00824894 0.0000001904858 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.00017977 3.45e-05 0.000000191 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0428822 0.00824898 0.0000002036199 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf 0.0428005 0.00824901 0.0000002147399 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0427592 0.00824902 0.0000002205916 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0427562 0.00824902 0.0000002210176 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.060024 0.0116438 0.0000002569087 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg18667319 chr3:47458823 3 47458823 SCAP North shore -0.206025 0.0401002 0.0000002808946 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0101 0.00202536 0.000000307 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0421556 0.00824923 0.0000003257907 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.012 0.0024 0.00000034 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0420602 0.00824927 0.0000003463287 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0489636 0.0096405 0.0000003841892 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0418477 0.00824934 0.0000003966674 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0641234 0.0126706 0.0000004225336 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_4 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0076 0.0015 0.00000043 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.041676 0.0082494 0.0000004424379 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27386529 chr3:47517807 3 47517807 SCAP South shore None None 0.00000045 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0708165 0.014037 0.0000004589897 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0415085 0.00824946 0.0000004919764 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0413758 0.0082495 0.000000535008 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0412087 0.00824956 0.0000005943013 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0411231 0.00824959 0.0000006271309 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.171191 0.0343496 0.000000629517 None 39706196_Hannah-M.-Smith_body_fat_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.02444 0.00475 0.00000064 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0410293 0.00824962 0.0000006650532 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0409501 0.00824965 0.0000006988051 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0409469 0.00824965 0.0000007001892 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0278 0.0056 0.00000071 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.169324 0.0342449 0.0000007704719 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 African ancestry Table S6 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 Whole blood - 2423 3 56 Both African cg21581415 chr3:47460784 3 47460784 SCAP South shore 4.37e-05 8.88e-06 0.00000084 - 27843151_alcohol_consumption_per_day_african_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0452875 0.00924767 0.0000009826118 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0403607 0.00824984 0.000001007203 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0403213 0.00824986 0.000001031946 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0401542 0.00824991 0.000001143526 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0400864 0.00824994 0.000001192025 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -0.0400789 0.00824994 0.000001197468 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0397106 0.00825006 0.000001498837 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0396817 0.00825007 0.000001525344 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18667319 chr3:47458823 3 47458823 SCAP North shore -0.001 0.00022 0.0000016 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0472351 0.00986894 0.000001715914 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0393712 0.00825017 0.000001840146 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0393552 0.00825017 0.000001857855 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg26614073 chr3:47517819 3 47517819 SCAP South shore None None 0.000002 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0391539 0.00825024 0.000002096555 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0391476 0.00825024 0.000002104462 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0390993 0.00825026 0.000002166141 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0390734 0.00825027 0.000002199934 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02020985 chr3:47475621 3 47475621 SCAP Open sea 0.0390731 0.00825027 0.000002200369 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0390363 0.00825028 0.000002249244 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0390163 0.00825028 0.000002276365 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0548267 0.0116232 0.000002415652 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.019 0.00404 0.0000026 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.00054665 0.0001159 0.00000272 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0386861 0.00825039 0.000002770122 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00190319 chr3:47462780 3 47462780 SCAP South shelf -0.00063 0.00014 0.0000028 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.025 0.00537 0.000003 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.038533 0.00825044 0.000003032502 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf 0.038527 0.00825044 0.000003043277 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0383973 0.00825048 0.000003284879 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.23597 0.0508739 0.00000353675 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.171055 0.0369311 0.000003652496 None 39706196_Hannah-M.-Smith_bmi_sensitivity Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.00621 0.00134 0.0000037 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0539991 0.0116744 0.000003770075 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0536595 0.0116667 0.000004272943 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0378679 0.00825065 0.00000447584 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0377078 0.0082507 0.000004910989 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0377032 0.0082507 0.000004924164 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0381642 0.00835173 0.000004926158 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf 0.0374399 0.00825078 0.000005731201 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -1.1 0.232 0.0000059 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0373891 0.0082508 0.000005900761 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.159634 0.0352994 0.000006158009 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0525353 0.0116501 0.000006550177 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg26614073 chr3:47517819 3 47517819 SCAP South shore None None 0.000007 None 31789449_Dugue-P-A_alcohol_consumption_replication Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 1 0.23 0.0000072 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0369196 0.00825094 0.000007713484 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16668081 chr3:47468720 3 47468720 SCAP Open sea 0.167656 0.0375023 0.000007851691 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0367691 0.00825099 0.0000083992 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0367003 0.00825101 0.000008731892 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27386529 chr3:47517807 3 47517807 SCAP South shore None None 0.0000089 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0366575 0.00825102 0.000008945094 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0365664 0.00825105 0.000009415883 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0365628 0.00825105 0.000009434812 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0438322 0.00989762 0.000009555249 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0368831 0.00836653 0.00001048723 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.042507 0.00965826 0.00001084656 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0614649 0.0139765 0.00001101629 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0403996 0.00918856 0.00001106702 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore - - 0.0000116 - 26500701_sex_kora_f4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.04 0.00907 0.000012 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0361033 0.00825119 0.00001219735 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0457127 0.0104581 0.00001245102 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0604287 0.0138266 0.0000124831 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02020985 chr3:47475621 3 47475621 SCAP Open sea 0.0360459 0.00825121 0.00001259291 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0359995 0.00825122 0.00001292069 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -3.1 0.7 0.000013 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg11704818 chr3:47517781 3 47517781 SCAP South shore -0.00638 0.00147 0.000014 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf 0.0357566 0.00825129 0.00001477652 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0602888 0.0139381 0.00001532277 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0354924 0.00825137 0.00001708248 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0354844 0.00825137 0.00001715776 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg12806346 chr3:47463481 3 47463481 SCAP South shelf -0.132784 0.0308999 0.00001738304 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0415422 0.00967529 0.00001768964 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0354192 0.00825139 0.00001777995 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.023 0.00534 0.000018 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0500009 0.0116655 0.00001829071 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0569368 0.01329 0.00001845835 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0497445 0.0116136 0.00001853283 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20288994 chr3:47483991 3 47483991 SCAP Open sea 0.0352966 0.00825143 0.00001900872 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0613584 0.0143462 0.00001906435 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg16668081 chr3:47468720 3 47468720 SCAP Open sea -0.155882 0.036454 0.00001911554 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.0352846 0.00825143 0.00001913309 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24051786 chr3:47514673 3 47514673 SCAP North shelf 0.194044 0.0454521 0.00001972237 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0352283 0.00825145 0.00001972774 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0606914 0.0142341 0.0000202231 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.041212 0.00967352 0.00002054387 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14700577 chr3:47517001 3 47517001 SCAP Island -0.00016861 3.94e-05 0.0000208 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0351084 0.00825148 0.00002105335 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0351054 0.00825148 0.00002108746 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0610432 0.0143488 0.00002110756 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0393508 0.00925052 0.00002113863 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0350287 0.0082515 0.00002198129 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0349656 0.00825152 0.00002274337 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0349453 0.00825153 0.00002299322 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0591773 0.013979 0.0000231681 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0417947 0.0098809 0.00002352719 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0348916 0.00825154 0.000023669 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Montano C - 27074206 2016-05-01 Schizophrenia EFO_0000692 Discovery Table S3 DNA methylation Schizophrenia Age, sex, smoking, ethnicity, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1334 3 38.6 Both European,African cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.006 0.0014 0.0000238 - 27074206_schizophrenia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0348235 0.00825156 0.00002455195 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CXCL13 protein levels (SeqId = 3487-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CXCL13 protein levels (SeqId = 3487-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-X-C motif chemokine 13 774 1 Adults (18-65 years) Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf -1.09 0.259 0.000025 None Gadd-DA_cxcl13_protein_levels__seqid___3487-32__somascan_protein_measurement Aghagoli G The Neonatal Neurobehavior and Outcomes in Very Preterm Infants 32967004 07-04-2021 cry acoustics factor 1 None None Supplementary Table 1 cry acoustics factor 1 DNA methylation Sex, PMA, recruitment site, proportions of epithelial cells None Beta values Illumina HumanMethylationEPIC Buccal None 335 1 Infants Both European cg11116314 chr3:47469834 3 47469834 SCAP Open sea 0.006 0.002 0.000025 None 32967004_Aghagoli-G_cry_acoustics_factor_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore - - 0.0000251 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0589907 0.0140028 0.00002537697 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf 0.034748 0.00825159 0.00002556756 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0347075 0.0082516 0.00002612941 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0347061 0.0082516 0.00002614923 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.0346664 0.00825161 0.00002671119 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.221038 0.05285 0.00002899175 None 39706196_Hannah-M.-Smith_bmi_discovery Battram T GEO 24603599 2020-09-15 Frontotemporal dementia Orphanet_282 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53740 None DNA methylation Frontotemporal dementia Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 314 1 Geriatrics Both Unclear cg16586182 chr3:47516702 3 47516702 SCAP North shore 0.0405 0.00953 0.000029 None 24603599_Battram-T_frontotemporal_dementia_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53740 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg20288994 chr3:47483991 3 47483991 SCAP Open sea -0.16939 0.0405057 0.00002904691 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09655299 chr3:47518115 3 47518115 SCAP South shore -0.0344995 0.00825166 0.00002920171 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0350024 0.00837213 0.0000292142 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0344875 0.00825166 0.00002938993 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.140687 0.0336686 0.00002947203 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0344788 0.00825166 0.00002952534 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0448964 0.0107706 0.00003084768 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0062 0.0015 0.000031 - 27651444_smoking_current_vs_never_smoking Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.026 0.00614 0.000032 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0593468 0.0142815 0.0000326433 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 PFKFB3 protein levels (SeqId = 12456-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PFKFB3 protein levels (SeqId = 12456-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.11 0.268 0.000033 None Gadd-DA_pfkfb3_protein_levels__seqid___12456-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.051995 0.0125219 0.00003309694 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0480141 0.0115632 0.00003309804 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0442887 0.0106887 0.00003439484 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0383156 0.00925498 0.00003492499 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.038324 0.00925964 0.0000351037 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0340854 0.00825177 0.00003637069 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0576222 0.0139621 0.00003695142 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 TREML2 protein levels (SeqId = 5736-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TREML2 protein levels (SeqId = 5736-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trem-like transcript 2 protein 774 1 Adults (18-65 years) Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf -1.07 0.26 0.000037 None Gadd-DA_treml2_protein_levels__seqid___5736-1__somascan_protein_measurement Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0035 0.00082 0.000038 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0339952 0.0082518 0.00003813922 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.0339917 0.0082518 0.00003821025 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0374054 0.00908721 0.00003871655 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14700577 chr3:47517001 3 47517001 SCAP Island -0.0026 0.00064 0.000039 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 C1orf43 protein levels (SeqId = 6937-251) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C1orf43 protein levels (SeqId = 6937-251) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Uncharacterized protein C1orf43 774 1 Adults (18-65 years) Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore -0.61 0.148 0.000039 None Gadd-DA_c1orf43_protein_levels__seqid___6937-251__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0479158 0.0116492 0.00003923023 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0339319 0.00825182 0.00003942959 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.039743 0.00966549 0.00003946414 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea -0.0339216 0.00825182 0.00003964405 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.0339016 0.00825183 0.00004006068 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.279556 0.0681308 0.00004091912 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0471651 0.0115216 0.00004269775 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.269369 0.0658142 0.00004279982 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0378626 0.00925622 0.00004327291 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0337332 0.00825187 0.00004375326 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf 0.033651 0.0082519 0.0000456708 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MMP19 protein levels (SeqId = 6425-87) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MMP19 protein levels (SeqId = 6425-87) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Matrix metalloproteinase-19 774 1 Adults (18-65 years) Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf -1.06 0.26 0.000046 None Gadd-DA_mmp19_protein_levels__seqid___6425-87__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF43 protein levels (SeqId = 14120-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF43 protein levels (SeqId = 14120-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RNF43 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.09 0.268 0.000046 None Gadd-DA_rnf43_protein_levels__seqid___14120-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMEM190 protein levels (SeqId = 10442-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM190 protein levels (SeqId = 10442-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein 190 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.089 0.267 0.000047 None Gadd-DA_tmem190_protein_levels__seqid___10442-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TMEM70 protein levels (SeqId = 8074-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMEM70 protein levels (SeqId = 8074-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protein 70, mitochondrial 774 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -1.42 0.349 0.000047 None Gadd-DA_tmem70_protein_levels__seqid___8074-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C21orf33 protein levels (SeqId = 5981-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C21orf33 protein levels (SeqId = 5981-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.09 0.268 0.000048 None Gadd-DA_c21orf33_protein_levels__seqid___5981-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0474889 0.0116787 0.00004802136 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0473643 0.0116835 0.00005062015 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0334482 0.00825195 0.00005074503 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf 0.0334199 0.00825196 0.00005149435 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20288994 chr3:47483991 3 47483991 SCAP Open sea 0.0336083 0.00830934 0.00005267112 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0333756 0.00825197 0.0000526891 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0375204 0.00928437 0.00005344052 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0560011 0.0138699 0.00005427531 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf 0.0333042 0.00825199 0.00005466899 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0332846 0.008252 0.00005522681 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg11704818 chr3:47517781 3 47517781 SCAP South shore -0.00066 0.00016 0.000058 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.03315 0.00825203 0.00005918945 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.234388 0.0583908 0.00005990726 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0331024 0.00825205 0.00006065412 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0099 0.0025 0.000061 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 SUV420H2 protein levels (SeqId = 12452-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUV420H2 protein levels (SeqId = 12452-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone-lysine N-methyltransferase KMT5C 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.07 0.268 0.000061 None Gadd-DA_suv420h2_protein_levels__seqid___12452-32__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27386529 chr3:47517807 3 47517807 SCAP South shore -0.0335788 0.00838232 0.00006208393 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26614073 chr3:47517819 3 47517819 SCAP South shore -0.141669 0.0353847 0.00006262516 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0370209 0.00925009 0.00006305898 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea -0.0370002 0.00924794 0.00006340915 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 MCL1 protein levels (SeqId = 10396-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MCL1 protein levels (SeqId = 10396-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Induced myeloid leukemia cell differentiation protein Mcl-1 774 1 Adults (18-65 years) Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore -0.59 0.149 0.000064 None Gadd-DA_mcl1_protein_levels__seqid___10396-6__somascan_protein_measurement Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 9.72e-05 2.43e-05 0.000064 - 27843151_alcohol_consumption_per_day_european_ancestry Gadd DA Generation Scotland 35945220 31/07/2022 ETFA protein levels (SeqId = 17435-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ETFA protein levels (SeqId = 17435-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Electron transfer flavoprotein subunit alpha, mitochondrial 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.07 0.268 0.000064 None Gadd-DA_etfa_protein_levels__seqid___17435-43__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg12578501 chr3:47469114 3 47469114 SCAP Open sea 0.156966 0.0392621 0.00006415925 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22754660 chr3:47462875 3 47462875 SCAP South shelf -0.123351 0.0308638 0.00006452154 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 PLCG1 protein levels (SeqId = 4563-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLCG1 protein levels (SeqId = 4563-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.07 0.267 0.000065 None Gadd-DA_plcg1_protein_levels__seqid___4563-61__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0463404 0.011606 0.00006561704 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0329479 0.00825209 0.00006564984 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ACRV1 protein levels (SeqId = 15301-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACRV1 protein levels (SeqId = 15301-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acrosomal protein SP-10 774 1 Adults (18-65 years) Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore -0.59 0.149 0.000066 None Gadd-DA_acrv1_protein_levels__seqid___15301-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 WFDC6 protein levels (SeqId = 13412-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WFDC6 protein levels (SeqId = 13412-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: WAP four-disulfide core domain protein 6 774 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 1.28 0.321 0.000066 None Gadd-DA_wfdc6_protein_levels__seqid___13412-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea 0.0329019 0.0082521 0.00006721155 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LRFN1 protein levels (SeqId = 7910-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRFN1 protein levels (SeqId = 7910-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat and fibronectin type III domain-containing protein 1 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.06 0.267 0.000069 None Gadd-DA_lrfn1_protein_levels__seqid___7910-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PIK3C2A protein levels (SeqId = 14028-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PIK3C2A protein levels (SeqId = 14028-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.06 0.267 0.00007 None Gadd-DA_pik3c2a_protein_levels__seqid___14028-22__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea -0.263416 0.0662426 0.00007021373 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0462973 0.0116656 0.0000726082 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.032745 0.00825214 0.00007280454 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 VSTM4 protein levels (SeqId = 7242-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VSTM4 protein levels (SeqId = 7242-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: V-set and transmembrane domain-containing protein 4 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.06 0.267 0.000073 None Gadd-DA_vstm4_protein_levels__seqid___7242-14__somascan_protein_measurement Jenny van Dongen BIOS consortium, GoDMC 34584077 Sep 28, 2021 monozygotic twinning None None supplemental table 3 DNA methylation monozygotic twinning Age, Sex, Smoking, Cell composition (reference free), Cell composition (reference based), Batch effects, Body mass index Beta values None Illumina HumanMethylation450 whole blood we used 450k and EPIC. some cohorts measured the cell counts, others estimated the cell counts with a referenc-based method 5723 5 Adults (18-65 years) Both European cg06333135 chr3:47460006 3 47460006 SCAP Island None None 0.000074 None 34584077_Jenny-van-Dongen_monozygotic_twinning Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26444411 chr3:47469671 3 47469671 SCAP Open sea 0.0326093 0.00825218 0.00007799514 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24574902 chr3:47455785 3 47455785 SCAP North shelf -0.0437782 0.0110851 0.00007875554 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg24051786 chr3:47514673 3 47514673 SCAP North shelf -0.175244 0.0443994 0.00007943323 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24051786 chr3:47514673 3 47514673 SCAP North shelf -0.0325543 0.0082522 0.000080197 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ICAM2 protein levels (SeqId = 5486-73) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ICAM2 protein levels (SeqId = 5486-73) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Intercellular adhesion molecule 2 774 1 Adults (18-65 years) Both European cg15665967 chr3:47459257 3 47459257 SCAP North shore -0.59 0.149 0.000081 None Gadd-DA_icam2_protein_levels__seqid___5486-73__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CNDP2 protein levels (SeqId = 3192-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNDP2 protein levels (SeqId = 3192-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytosolic non-specific dipeptidase 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.05 0.267 0.000082 None Gadd-DA_cndp2_protein_levels__seqid___3192-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 REPIN1 protein levels (SeqId = 13554-78) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 REPIN1 protein levels (SeqId = 13554-78) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Replication initiator 1 774 1 Adults (18-65 years) Both European cg11483335 chr3:47497530 3 47497530 SCAP Open sea 0.45 0.115 0.000084 None Gadd-DA_repin1_protein_levels__seqid___13554-78__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0398332 0.010137 0.0000855227 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17887974 chr3:47464389 3 47464389 SCAP Open sea 0.0397535 0.010125 0.00008666512 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20288994 chr3:47483991 3 47483991 SCAP Open sea 0.032525 0.00828914 0.00008755769 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25831408 chr3:47506925 3 47506925 SCAP Open sea 0.0323767 0.00825224 0.00008771213 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.0547163 0.0139621 0.0000893541 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07833663 chr3:47484909 3 47484909 SCAP Open sea 0.0556865 0.0142182 0.00009022912 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg15561453 chr3:47459664 3 47459664 SCAP Island -0.00042575 0.00010833 0.0000904 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Gadd DA Generation Scotland 35945220 31/07/2022 MACROD1 protein levels (SeqId = 13653-335) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MACROD1 protein levels (SeqId = 13653-335) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribose glycohydrolase MACROD1 774 1 Adults (18-65 years) Both European cg17166998 chr3:47464015 3 47464015 SCAP South shelf -1.05 0.268 0.000091 None Gadd-DA_macrod1_protein_levels__seqid___13653-335__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg17806245 chr3:47469820 3 47469820 SCAP Open sea 0.170417 0.0435577 0.0000917154 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 F8 protein levels (SeqId = 13499-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 F8 protein levels (SeqId = 13499-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coagulation factor VIII 774 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -1.07 0.273 0.000092 None Gadd-DA_f8_protein_levels__seqid___13499-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0455761 0.0116508 0.00009200029 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg16668081 chr3:47468720 3 47468720 SCAP Open sea 0.146804 0.0375933 0.00009456163 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15561453 chr3:47459664 3 47459664 SCAP Island 0.0385661 0.00988704 0.00009635256 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore 0.043659 0.0111956 0.00009675415 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26689240 chr3:47464073 3 47464073 SCAP Open sea -0.0321702 0.0082523 0.00009728924 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21581415 chr3:47460784 3 47460784 SCAP South shore -0.0453696 0.0116497 0.00009884509 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24383480 chr3:47466266 3 47466266 SCAP Open sea 0.0063 0.0016 0.000099 None 33450751_Mulder-RH_sex_discovery