author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -0.012 0.00027 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.029 0.0014 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10691809 chr22:31892045 22 31892045 SFI1 Island -0.00035 0.000033 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12737971 chr22:31892148 22 31892148 SFI1 Island -0.00012 0.000013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.004 0.00027 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.017 0.0019 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23702117 chr22:31897078 22 31897078 SFI1 South shelf -0.0025 0.00029 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.55525 0.00662 9.3e-154 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea 0.64839 0.00816 2.1e-149 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.25423 0.00408 1e-129 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea - - 2.5699999999999997e-112 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.117921 0.00819897 1.384758e-46 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3957938 (gene symbol: PISD) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3957938 (gene symbol: PISD) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg02404636 chr22:31891804 22 31891804 SFI1 North shore None None 7.399999999999999e-43 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3957938__gene_symbol__pisd__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.110548 0.00820597 4.034334e-41 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.108255 0.00820805 1.706861e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.01533 0.00122 1.7e-36 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0989761 0.00821603 2.8974950000000003e-33 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0973471 0.00821736 3.1461880000000003e-32 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08226295 chr22:31892562 22 31892562 SFI1 Island 0.01968 0.00138 4.5e-32 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0942257 0.00821984 2.717204e-30 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 2.3 0.215 1.7000000000000002e-27 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0838982 0.00822746 2.4566819999999998e-24 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea 0.0016 None 7.000000000000001e-24 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0810117 0.00822943 8.549226e-23 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0786859 0.00823097 1.364537e-21 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.076626 0.0082323 1.4843279999999998e-20 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0761293 0.00823261 2.614519e-20 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.074776 0.00823346 1.20017e-19 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0744257 0.00823367 1.772763e-19 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0741931 0.00823382 2.29448e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.0098 0.0009 1.2e-18 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0719958 0.00823515 2.524413e-18 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.0148 0.0017 3.1e-18 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0716534 0.00823535 3.644671e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0703978 0.00823609 1.3808920000000002e-17 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0697268 0.00823648 2.787144e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11956866 chr22:31998253 22 31998253 SFI1 Open sea 0.05933 0.0064 3.8e-17 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0693411 0.0082367 4.160923e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg08305533 chr22:32007224 22 32007224 SFI1 Open sea None None 4.5e-17 None 31789449_Dugue-P-A_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0686726 0.00823708 8.290824000000001e-17 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.067355 0.00823782 3.164645e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0673079 0.00823785 3.318379e-16 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0669593 0.00823804 4.708546e-16 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03211283 chr22:31893096 22 31893096 SFI1 Island -0.03056 0.00347 7.8e-16 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0646888 0.00823928 0.000000000000004402331 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0640602 0.00823961 0.000000000000008065991 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0637685 0.00823977 0.00000000000001066245 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg08226295 chr22:31892562 22 31892562 SFI1 Island 2.662664 0.3483 0.0000000000000208 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0627528 0.0082403 0.00000000000002789954 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.0616406 0.00824087 0.00000000000007861668 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0614819 0.00824095 0.0000000000000910071 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0612639 0.00824106 0.0000000000001112046 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0610477 0.00824117 0.0000000000001355609 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0609342 0.00824123 0.0000000000001503778 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03211283 chr22:31893096 22 31893096 SFI1 Island -0.00061 0.000083 0.00000000000021 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0604119 0.00824149 0.0000000000002417885 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0954584 0.0130636 0.0000000000002868785 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.034 0.00477 0.00000000000072 None Robert-F-Hillary_Incident_COPD_Basic_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02404636 chr22:31891804 22 31891804 SFI1 North shore -0.0165 0.00216 0.0000000000011 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0584077 0.00824248 0.000000000001441406 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.222087 0.0315201 0.000000000001909021 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.284839 0.0404817 0.000000000002045053 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0575126 0.00824291 0.00000000000313965 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0574356 0.00824294 0.000000000003355245 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0773189 0.0112109 0.000000000005538548 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0772783 0.0112498 0.000000000006711074 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0560649 0.00824358 0.0000000000107889 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea -0.0011 0.00016 0.000000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0771436 0.0113958 0.00000000001341791 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0556683 0.00824377 0.00000000001504933 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0551775 0.00824399 0.00000000002264808 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0551583 0.008244 0.00000000002301281 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0546773 0.00824422 0.00000000003423081 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg22480555 chr22:31892067 22 31892067 SFI1 Island 0.0085 0.0013 0.000000000036 - 23334450_rheumatoid_arthritis Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 1.4 0.219 0.000000000037 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.0545512 0.00824428 0.00000000003796488 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0588397 0.008939 0.00000000004787721 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22480555 chr22:31892067 22 31892067 SFI1 Island 0.00038 None 0.000000000048 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0541272 0.00824447 0.00000000005368024 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0540469 0.0082445 0.00000000005730744 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.07178 0.0110803 0.00000000009580389 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0736551 0.0113844 0.0000000001012426 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23702117 chr22:31897078 22 31897078 SFI1 South shelf 0.0023 None 0.00000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.0009865 0.00015188 0.000000000128 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0529722 0.00824498 0.0000000001361279 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg21533369 chr22:31892152 22 31892152 SFI1 Island -1.456399 0.2274 0.000000000152 - 27105112_hiv_infection_discovery Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg00184884 chr22:31892343 22 31892343 SFI1 Island 0.00632 0.001 0.000000000164 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16311410 chr22:31892793 22 31892793 SFI1 Island 0.0521058 0.00824536 0.0000000002701342 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0752235 0.0119736 0.0000000003427714 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 1.696002 0.2707 0.000000000373 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0710981 0.0113836 0.0000000004335996 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0513538 0.00824568 0.0000000004854016 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0513269 0.00824569 0.0000000004956378 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.044 0.00706 0.00000000069 None Robert-F-Hillary_Incident_COPD_Basic_model Zeilinger S - 23691101 2013-05-17 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking discovery Table S1 DNA methylation Smoking Age, sex, body mass index, alcohol consumption and cell counts M values - Illumina HumanMethylation450 Whole blood - 1011 1 60.8 Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea - - 0.000000000754 - 23691101_smoking_current_vs_never_smoking_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 1.9 0.313 0.00000000085 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.390365 0.0638331 0.0000000009827281 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08226295 chr22:31892562 22 31892562 SFI1 Island 0.00508 0.00084 0.0000000014 None 33279932_Li-M_schizophrenia_main Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0791377 0.0130814 0.000000001487156 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0498611 0.0082463 0.000000001516347 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0497127 0.00824636 0.000000001695256 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.0494234 0.00824648 0.000000002104786 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0491452 0.00824659 0.000000002588906 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0489766 0.00824666 0.000000002933315 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.048821 0.00824673 0.000000003290452 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0486061 0.00824681 0.000000003854086 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0666615 0.0113379 0.00000000420374 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0481161 0.00824701 0.000000005513314 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0515315 0.00889672 0.000000007089958 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0474909 0.00824726 0.000000008662403 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0754957 0.0131204 0.000000008887178 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.028 0.00481 0.0000000089 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0468918 0.00824749 0.00000001328459 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.04685 0.00824751 0.00000001368417 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0468187 0.00824752 0.0000000139911 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0467908 0.00824753 0.00000001427101 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0467726 0.00824754 0.00000001445578 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01168649 chr22:31892074 22 31892074 SFI1 Island 0.00611 0.00103 0.000000015 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea -0.0465233 0.00824763 0.00000001723794 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16311410 chr22:31892793 22 31892793 SFI1 Island 0.0464218 0.00824767 0.00000001851444 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0734227 0.013052 0.00000001884389 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.024 0.00392 0.000000022 None 32795589_Kyung-WK_atopy_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11956866 chr22:31998253 22 31998253 SFI1 Open sea -0.249745 0.0446898 0.00000002324525 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.072943 0.0130729 0.00000002451943 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea 0.346239 0.0622028 0.00000002638794 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0739965 0.0132989 0.00000002681309 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0495971 0.00893451 0.00000002886772 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0457108 0.00824794 0.00000003040404 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0611651 0.0110675 0.00000003321055 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0720771 0.0130503 0.00000003388456 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0454729 0.00824803 0.00000003583566 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08305533 chr22:32007224 22 32007224 SFI1 Open sea None None 0.000000036 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg12114049 chr22:31892114 22 31892114 SFI1 Island 0.00158 0.00029 0.000000043 None 33279932_Li-M_schizophrenia_main Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.025 0.00417 0.000000054 None 32795589_Kyung-WK_eosinophilia_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -1.6 0.303 0.00000006 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0447068 0.00824832 0.00000006050374 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0446799 0.00824833 0.00000006161542 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21806053 chr22:32009606 22 32009606 SFI1 Open sea 0.0445819 0.00824836 0.00000006584344 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0444982 0.00824839 0.00000006967549 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11956866 chr22:31998253 22 31998253 SFI1 Open sea 0.00088 None 0.000000071 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0444461 0.00824841 0.00000007216699 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0443904 0.00824843 0.00000007492827 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -0.10223 0.0191 0.0000000806 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea -0.0442575 0.00824848 0.00000008193815 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0441451 0.00824852 0.00000008835558 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg21806053 chr22:32009606 22 32009606 SFI1 Open sea -0.298351 0.0557589 0.00000008865684 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0477609 0.00894676 0.00000009519341 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0440154 0.00824857 0.00000009636813 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08226295 chr22:31892562 22 31892562 SFI1 Island None None 0.0000001 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0588246 0.0110414 0.0000001009588 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0941593 0.017694 0.0000001044073 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0438489 0.00824863 0.0000001076859 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg12737971 chr22:31892148 22 31892148 SFI1 Island -1.153639 0.2171 0.000000108 - 27105112_hiv_infection_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.171871 0.0323717 0.0000001114173 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0435261 0.00824875 0.0000001334096 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -1.3 0.254 0.00000014 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0684515 0.0130231 0.0000001491699 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.14555 0.0277438 0.0000001570626 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0579047 0.0110567 0.0000001654106 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0584009 0.0112221 0.0000001975953 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.042825 0.008249 0.0000002113415 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0428033 0.008249 0.0000002143528 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0681968 0.0131459 0.000000215745 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0427285 0.00824903 0.0000002250332 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0588812 0.0113691 0.0000002259399 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.138879 0.0268543 0.0000002345764 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.0426489 0.00824906 0.00000023698 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0670094 0.013072 0.000000299418 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg12114049 chr22:31892114 22 31892114 SFI1 Island None None 0.00000031 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0927021 0.0181177 0.0000003149285 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0422054 0.00824921 0.0000003155236 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -0.00061326 0.00011921 0.00000032 - 27717397_gestational_age_ultrasoundestimated_gestational_age Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea - - 0.00000037 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0453528 0.00891763 0.0000003706935 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.041922 0.00824931 0.0000003783199 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0417591 0.00824937 0.0000004196926 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0573845 0.0113483 0.0000004317806 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01036541 chr22:32009659 22 32009659 SFI1 Open sea -0.24575 0.0486279 0.0000004375663 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0416365 0.00824941 0.0000004536881 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0416344 0.00824941 0.0000004542935 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0596278 0.0118268 0.0000004667535 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0414795 0.00824947 0.0000005010806 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0552997 0.0110235 0.0000005322409 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0910236 0.0181463 0.0000005334772 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0412952 0.00824953 0.0000005628597 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0432929 0.0086797 0.0000006175926 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.041132 0.00824958 0.000000623638 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -1.1 0.22 0.00000065 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0410494 0.00824961 0.0000006567347 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0649989 0.0131337 0.0000007542517 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0442121 0.00894712 0.000000783836 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0406899 0.00824973 0.0000008216886 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.040616 0.00824976 0.0000008602434 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0405184 0.00824979 0.0000009137851 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0639836 0.0130639 0.000000979756 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.0402619 0.00824988 0.000001070365 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0402597 0.00824988 0.00000107181 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.0402417 0.00824988 0.00000108372 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0402212 0.00824989 0.000001097434 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0401296 0.00824992 0.000001160927 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.040126 0.00824992 0.000001163432 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16311410 chr22:31892793 22 31892793 SFI1 Island 0.040098 0.00824993 0.000001183557 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0331 0.0068 0.0000012 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0538407 0.0110872 0.000001209573 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0398612 0.00825001 0.000001367681 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0398564 0.00825001 0.000001371703 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0398477 0.00825001 0.000001379002 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0398303 0.00825002 0.000001393696 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01036541 chr22:32009659 22 32009659 SFI1 Open sea 0.240809 0.0499359 0.000001430707 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.039437 0.00825015 0.00000176858 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg01332634 chr22:31974816 22 31974816 SFI1 Open sea -0.043 0.00897 0.0000018 None Robert-F-Hillary_Incident_COPD_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26207309 chr22:31892053 22 31892053 SFI1 Island -0.00024 0.000051 0.0000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.039317 0.00825019 0.000001901085 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0424241 0.00890415 0.000001911082 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0392605 0.00825021 0.00000196676 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0392151 0.00825022 0.000002021093 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Cecil CA - 27922636 2016-12-06 Substance use EFO_000432, EFO_0007585, EFO_0004318 DNA methylation at birth Table 1 Substance use DNA methylation Sex, cell counts and technical covariates - Beta values Illumina HumanMethylation450 Cord blood Association between cord blood DNA methylation and self-reported substance use recorded at ages 14, 16 and 18 244 1 - Both None cg02404636 chr22:31891804 22 31891804 SFI1 North shore 0.29 0.0611 0.0000021 - 27922636_substance_use_dna_methylation_at_birth Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0391277 0.00825025 0.000002129711 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0527396 0.0111283 0.000002165586 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08941595 chr22:31952631 22 31952631 SFI1 Open sea -0.0390856 0.00825026 0.000002184016 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea -0.300561 0.0635606 0.000002277092 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.0389911 0.00825029 0.000002310817 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0388463 0.00825034 0.000002518911 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0388282 0.00825035 0.00000254618 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.0388138 0.00825035 0.000002568115 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.052967 0.0112953 0.000002766257 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.151752 0.0324518 0.000002943849 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0385233 0.00825044 0.000003049871 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg24112255 chr22:32009807 22 32009807 SFI1 Open sea -0.212921 0.0456176 0.000003070457 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea 0.0042 None 0.0000032 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.185912 0.0399248 0.000003238324 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea -0.0384117 0.00825048 0.000003257303 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0416472 0.00894862 0.000003283426 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg26207309 chr22:31892053 22 31892053 SFI1 Island 1.345629 0.2894 0.00000333 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11956866 chr22:31998253 22 31998253 SFI1 Open sea 0.0028 None 0.0000035 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0559876 0.0121096 0.000003807078 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0380893 0.00825058 0.000003934733 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0597568 0.0129483 0.000003963398 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0380325 0.0082506 0.000004067301 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11409519 chr22:32009686 22 32009686 SFI1 Open sea -0.214864 0.0466349 0.000004105806 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0407386 0.00885105 0.000004205745 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21806053 chr22:32009606 22 32009606 SFI1 Open sea 0.0379376 0.00825063 0.000004298143 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0379255 0.00825063 0.000004328507 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0461862 0.0100897 0.000004743423 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg14902306 chr22:31891830 22 31891830 SFI1 North shore -0.1361388 0.0297589 0.000004768 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.233007 0.0510087 0.000004956732 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0502493 0.0110225 0.000005186828 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0509274 0.0112021 0.000005504714 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0374249 0.00825079 0.000005780703 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0373986 0.0082508 0.000005868598 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0404725 0.00893283 0.00000592359 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0591208 0.0130626 0.000006059685 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0373261 0.00825082 0.000006117722 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMK protein levels (SeqId = 9545-156) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMK protein levels (SeqId = 9545-156) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme K 774 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.99 0.22 0.0000064 None Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0402951 0.00893625 0.000006558625 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0371666 0.00825087 0.000006701926 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02404636 chr22:31891804 22 31891804 SFI1 North shore -0.00056 0.00013 0.0000068 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20441712 chr22:32008978 22 32008978 SFI1 Open sea -0.0371375 0.00825088 0.000006814443 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0402401 0.00894595 0.000006907948 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0498037 0.0111111 0.000007438775 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0589103 0.013147 0.000007489295 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0369069 0.00825095 0.000007769025 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0099 0.00222 0.0000079 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0483675 0.0108706 0.000008675432 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0367022 0.00825101 0.000008722767 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.0366048 0.00825104 0.000009214478 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0365572 0.00825105 0.00000946492 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00184884 chr22:31892343 22 31892343 SFI1 Island 0.000092 0.000021 0.0000096 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0497793 0.0112488 0.000009700665 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.0364698 0.00825108 0.000009940688 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.039377 0.00892182 0.00001024114 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25464687 chr22:32010188 22 32010188 SFI1 Open sea -0.0373839 0.00847641 0.00001039405 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.03637 0.00825111 0.00001051208 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.0527331 0.0119645 0.00001053278 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16311410 chr22:31892793 22 31892793 SFI1 Island 0.0362422 0.00825115 0.00001128994 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25464687 chr22:32010188 22 32010188 SFI1 Open sea -0.036308 0.00827934 0.00001165938 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 LY9 protein levels (SeqId = 3324-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LY9 protein levels (SeqId = 3324-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-lymphocyte surface antigen Ly-9 774 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.63 0.143 0.000012 None Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22480555 chr22:31892067 22 31892067 SFI1 Island 0.0361189 0.00825118 0.0000120924 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0497239 0.0113908 0.00001278349 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0380327 0.00873282 0.00001338805 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0567191 0.0130374 0.00001367501 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0358845 0.00825125 0.00001376994 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.140436 0.0323081 0.00001389504 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0358598 0.00825126 0.00001395857 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea 0.0358266 0.00825127 0.00001421686 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0357972 0.00825128 0.00001444939 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.035779 0.00825129 0.00001459491 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25464687 chr22:32010188 22 32010188 SFI1 Open sea -0.035778 0.00825129 0.00001460352 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.00020172 4.66e-05 0.0000152 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0355481 0.00825135 0.00001656898 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0355478 0.00825135 0.00001657227 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25218872 chr22:31996918 22 31996918 SFI1 Open sea 0.220329 0.0511723 0.00001674236 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea -0.27484 0.0639799 0.00001750751 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg01168649 chr22:31892074 22 31892074 SFI1 Island 0.142097 0.0331 0.0000176 - 27105112_hiv_infection_neutrophils Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00184884 chr22:31892343 22 31892343 SFI1 Island 0.00391 0.00089 0.000018 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.0013 0.0003 0.000018 None 33450751_Mulder-RH_age_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0353735 0.0082514 0.00001822838 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0353522 0.00825141 0.00001844109 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0561476 0.0131148 0.00001870514 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.035311 0.00825142 0.00001885981 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0352977 0.00825143 0.0000189976 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.035234 0.00825144 0.00001966666 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.222743 0.0522333 0.00002015184 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.0350468 0.0082515 0.00002176682 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.055501 0.013074 0.00002197898 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0475838 0.0112092 0.00002198833 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0349472 0.00825153 0.0000229705 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08305533 chr22:32007224 22 32007224 SFI1 Open sea None None 0.000023 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.021 0.00497 0.000023 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14773971 chr22:31924660 22 31924660 SFI1 Open sea 0.0348081 0.00822612 0.00002336392 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0468199 0.0110689 0.000023526 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0552705 0.0130776 0.00002389451 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0348385 0.00825156 0.00002435514 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14773971 chr22:31924660 22 31924660 SFI1 Open sea 0.0348374 0.00825156 0.00002436965 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.034824 0.00825156 0.00002454589 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0554295 0.0131414 0.0000248051 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0472254 0.0111973 0.00002484147 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.0514502 0.0122282 0.00002597455 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0470428 0.0111939 0.00002655085 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0469783 0.0111811 0.00002666301 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16311410 chr22:31892793 22 31892793 SFI1 Island 0.00019 0.000046 0.000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0345628 0.00825164 0.00002823182 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0345398 0.00825164 0.00002858062 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14773971 chr22:31924660 22 31924660 SFI1 Open sea 0.0344625 0.00823738 0.00002885094 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2 Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis adjusted model Table S2 DNA methylation Hypertensive disorders of pregnancy Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg08305533 chr22:32007224 22 32007224 SFI1 Open sea 0.006 0.0014 0.000029 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0344811 0.00825166 0.00002948929 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0545124 0.0130557 0.00002992135 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.205634 0.0492645 0.00003006644 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0543942 0.0130491 0.00003084929 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0456596 0.010954 0.00003086372 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Battram T GEO 25424692 2020-09-15 Smoking EFO_0004318, EFO_0005671, EFO_0006527 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers None DNA methylation Smoking Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 442 1 Adults Both European cg08226295 chr22:31892562 22 31892562 SFI1 Island -0.0056 0.00134 0.000031 None 25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers Soloman O - 28556291 2017-01-09 Prenatal phthalate exposure CHEBI_26092 13 weeks gestation Table S2 DNA methylation Prenatal phthalate exposure Pre-pregnancy body mass index, parity, years in USA, creatinine, cell counts and technical covariates M values mug/l Illumina HumanMethylation450 Cord blood Regression coefficients are per 10-fold increase in phthalate 321 1 0 Both Admixed cg23702117 chr22:31897078 22 31897078 SFI1 South shelf -0.20327071 0.048839 0.0000315 MCPP 28556291_prenatal_phthalate_exposure_13_weeks_gestation Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0460939 0.0110763 0.00003179819 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25218872 chr22:31996918 22 31996918 SFI1 Open sea 0.0340884 0.00825367 0.0000364635 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.034075 0.00825178 0.00003657117 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -0.00058139 0.00014025 0.0000366 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea 0.034 0.00832 0.000037 None Robert-F-Hillary_Incident_COPD_Basic_model Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore -0.00063798 0.00015406 0.0000373 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0340356 0.00825179 0.00003733738 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02887506 chr22:31927047 22 31927047 SFI1 Open sea -0.0340105 0.00825179 0.00003783311 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.0376035 0.0091254 0.00003797167 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0339912 0.0082518 0.00003822044 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11409519 chr22:32009686 22 32009686 SFI1 Open sea 0.197164 0.0479049 0.00003877472 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01036541 chr22:32009659 22 32009659 SFI1 Open sea 0.205921 0.0500594 0.00003914455 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0457297 0.0111259 0.0000397484 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25464687 chr22:32010188 22 32010188 SFI1 Open sea -0.0347106 0.00844996 0.00004016568 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0456313 0.0111163 0.00004066735 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0459994 0.0112126 0.00004109689 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.211907 0.0516972 0.00004168296 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0337878 0.00825186 0.00004252189 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25464687 chr22:32010188 22 32010188 SFI1 Open sea -0.0344516 0.00843217 0.00004417039 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.0336833 0.00825189 0.00004490685 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08305533 chr22:32007224 22 32007224 SFI1 Open sea None None 0.000045 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0532455 0.01305 0.0000452539 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.195617 0.0480007 0.00004614847 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.033596 0.00825191 0.00004699707 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0442172 0.0108668 0.00004745649 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea 0.0350013 0.00860732 0.00004798251 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0496881 0.0122459 0.00004985475 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0448291 0.0110625 0.00005096471 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Battram T ARIES None 2020-08-20 Concentration of very small VLDL particles EFO_0008317 None None DNA methylation Concentration of very small VLDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -13000000 None 0.000051 None Battram-T_concentration_of_very_small_vldl_particles Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 2.3 0.574 0.000051 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.0334335 0.00825196 0.00005113373 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0334288 0.00825196 0.00005125773 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.168859 0.0417148 0.0000518965 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0334001 0.00825196 0.00005202472 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0347806 0.00859658 0.00005239794 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0362159 0.00895143 0.00005240596 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02887506 chr22:31927047 22 31927047 SFI1 Open sea -0.0334205 0.00826296 0.00005267618 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.210242 0.0520331 0.00005356054 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 SPTAN1 protein levels (SeqId = 5031-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPTAN1 protein levels (SeqId = 5031-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Spectrin alpha chain, non-erythrocytic 1 774 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.64 0.16 0.000055 None Gadd-DA_sptan1_protein_levels__seqid___5031-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15791438 chr22:31893238 22 31893238 SFI1 South shore 0.033269 0.008252 0.00005567272 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0447131 0.0110926 0.00005584319 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Pain (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Pain (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 18413 1 Adults (18-65y) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.21 0.0521 0.000056 None Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0730011 0.0181244 0.00005659221 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0330995 0.00823092 0.00005815388 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0489676 0.0121801 0.00005841787 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0724696 0.0180364 0.000058997 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25218872 chr22:31996918 22 31996918 SFI1 Open sea 0.0330903 0.00824048 0.00005959475 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0331267 0.00825204 0.00005990266 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea 0.0330626 0.00825206 0.00006190757 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02887506 chr22:31927047 22 31927047 SFI1 Open sea -0.0328531 0.00820337 0.00006236855 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0477313 0.0119303 0.00006342374 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea 0.0348997 0.00872457 0.00006360861 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea -0.032993 0.00825208 0.00006415298 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea -0.0329595 0.00825209 0.00006526393 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0722164 0.0180976 0.00006628926 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08941595 chr22:31952631 22 31952631 SFI1 Open sea -0.0329257 0.00825209 0.00006640072 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08941595 chr22:31952631 22 31952631 SFI1 Open sea 0.0329201 0.0082521 0.00006658856 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea 0.0329199 0.0082521 0.00006659567 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22079361 chr22:31979888 22 31979888 SFI1 Open sea 0.0329095 0.0082521 0.00006695095 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea -0.0328249 0.00825212 0.00006990264 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0519686 0.0130681 0.00007019363 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0453565 0.0114102 0.00007069118 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea 0.0329714 0.00829616 0.00007092445 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08941595 chr22:31952631 22 31952631 SFI1 Open sea -0.0337103 0.00848422 0.00007122506 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 APOB protein levels (SeqId = 2797-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOB protein levels (SeqId = 2797-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein B-100 774 1 Adults (18-65 years) Both European cg02814896 chr22:31892350 22 31892350 SFI1 Island -0.89 0.223 0.000072 None Gadd-DA_apob_protein_levels__seqid___2797-56__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.0326742 0.00825216 0.00007546869 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01332634 chr22:31974816 22 31974816 SFI1 Open sea 0.0340633 0.0086038 0.00007558975 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0507162 0.0128125 0.00007583167 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea 0.0326632 0.00825217 0.0000758918 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02887506 chr22:31927047 22 31927047 SFI1 Open sea -0.0341641 0.00863316 0.00007615715 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Ischemic Heart Disease None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Ischemic Heart Disease Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17483 1 Adults (18-65y) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.021 0.0054 0.000077 None Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20441712 chr22:32008978 22 32008978 SFI1 Open sea -0.0326169 0.00825218 0.00007769645 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg04835068 chr22:31957393 22 31957393 SFI1 Open sea -0.022 0.00563 0.000078 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea -0.0437519 0.0110798 0.00007891182 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10511632 chr22:32008959 22 32008959 SFI1 Open sea -0.0325861 0.00825219 0.00007891471 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21806053 chr22:32009606 22 32009606 SFI1 Open sea -0.0325825 0.00825219 0.00007906185 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.0321272 0.00813857 0.00007933238 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea -0.0352303 0.00893524 0.00008089329 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.051646 0.0131091 0.00008196445 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 LY9 protein levels (SeqId = 3324-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LY9 protein levels (SeqId = 3324-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-lymphocyte surface antigen Ly-9 774 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.86 0.218 0.000082 None Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00071692 chr22:32006800 22 32006800 SFI1 Open sea 0.0325069 0.00825221 0.00008214232 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11435225 chr22:32014422 22 32014422 SFI1 Open sea 0.0324887 0.00825221 0.00008289869 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.123768 0.0314513 0.00008342636 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23049818 chr22:31892356 22 31892356 SFI1 Island 0.03247 0.00825222 0.00008368642 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12114049 chr22:31892114 22 31892114 SFI1 Island 0.0013 None 0.000084 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Chatziioannou A EnviroGenomarkers project consortium 28225026 2017-02-22 Tobacco smoking EFO_0006527, EFO_0005671, EFO_0004318 - Table S2 DNA methylation Current vs never smoking Age, sex, body mass index, study centre and cell counts M values - Illumina HumanMethylation450 Whole blood - 454 2 52 Both None cg08305533 chr22:32007224 22 32007224 SFI1 Open sea - - 0.0000844 - 28225026_tobacco_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea -0.044813 0.0114133 0.00008661963 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14575131 chr22:31933466 22 31933466 SFI1 Open sea 0.041563 0.0105859 0.00008666627 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CST2 protein levels (SeqId = 4324-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST2 protein levels (SeqId = 4324-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-SA 774 1 Adults (18-65 years) Both European cg02814896 chr22:31892350 22 31892350 SFI1 Island -0.87 0.222 0.000087 None Gadd-DA_cst2_protein_levels__seqid___4324-33__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00746322 chr22:32000496 22 32000496 SFI1 Open sea -0.0323902 0.00825224 0.00008711811 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FIGF protein levels (SeqId = 13098-93) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FIGF protein levels (SeqId = 13098-93) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vascular endothelial growth factor D 774 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.845 0.215 0.000088 None Gadd-DA_figf_protein_levels__seqid___13098-93__somascan_protein_measurement Hoang Agricultural Lung Health Study 34516295 Sep 13, 2021 picloram None discovery 10.5281/zenodo.5156585 DNA methylation picloram Age, Smoking, Cell composition (reference based), residence,asthma Beta values None Illumina HumanMethylationEPIC whole blood None 1011 1 Adults Males European cg01168649 chr22:31892074 22 31892074 SFI1 Island -0.0008 0.0002 0.000089 None 34516295_Hoang_picloram_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00193210 chr22:31985572 22 31985572 SFI1 Open sea 0.0466787 0.0119089 0.0000890844 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0323196 0.00825226 0.00009026784 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Battram T ARIES None 2020-08-20 Triglycerides in very small VLDL EFO_0004530 None None DNA methylation Triglycerides in very small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 680 1 Adults Females European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -3.2 0.81 0.000093 None Battram-T_triglycerides_in_very_small_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea 0.0510435 0.0130617 0.00009352769 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13796737 chr22:31968954 22 31968954 SFI1 Open sea 0.192557 0.049306 0.00009444879 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0509468 0.0130452 0.00009448424 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07113062 chr22:31943142 22 31943142 SFI1 Open sea -0.0437386 0.0111998 0.00009453595 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Battram T ARIES None 2020-08-20 Total lipids in small VLDL EFO_0004529 None None DNA methylation Total lipids in small VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 681 1 Adults Females European cg08305533 chr22:32007224 22 32007224 SFI1 Open sea -0.55 0.141 0.000095 None Battram-T_total_lipids_in_small_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25218872 chr22:31996918 22 31996918 SFI1 Open sea 0.0322119 0.00825229 0.00009527799 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21806053 chr22:32009606 22 32009606 SFI1 Open sea 0.0322046 0.00825229 0.00009562753 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Cronjé HT Prospective Urban and Rural Epidemiology study 31910897 2020-01-07 Low density lipoprotein cholesterol EFO_0004195, EFO_0004611 None Additional file 2e DNA methylation Low density lipoprotein cholesterol Age, cell composition (reference based), batch effects Beta Values mg/dL Illumina HumanMethylationEPIC Whole blood None 120 1 Adults Males African cg24112255 chr22:32009807 22 32009807 SFI1 Open sea 0.00069 0.00017 0.000096 None 31910897_Cronjé-HT_low_density_lipoprotein_cholesterol Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20441712 chr22:32008978 22 32008978 SFI1 Open sea -0.199366 0.0511248 0.00009672038 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0321748 0.0082523 0.0000970631 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23510357 chr22:31934920 22 31934920 SFI1 Open sea -0.0507705 0.0130351 0.00009867613 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_3