author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea -0.0019 0.00013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.001 0.000056 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19008809 chr3:53080682 3 53080682 SFMBT1 Island 0.00046 0.000049 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0024 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.013 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.27157 0.00388 3.7e-139 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24616795 chr3:53032891 3 53032891 SFMBT1 Island 0.0014 None 3.7e-74 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.135617 0.00818029 3.588784e-61 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.121457 0.00819545 2.4693419999999998e-49 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0006 None 3.7e-42 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0012 0.000082 2.0000000000000002e-39 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0724 0.00465 5.9999999999999996e-36 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0904754 0.00822271 4.751902000000001e-28 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0890227 0.00822379 3.320028e-27 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0887601 0.00822398 4.702423e-27 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19008809 chr3:53080682 3 53080682 SFMBT1 Island 0.01434 0.0012 7.399999999999999e-25 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0808683 0.00822953 1.016494e-22 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0767612 0.00823221 1.271576e-20 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0762733 0.00823252 2.2196939999999998e-20 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2676518 (gene symbol: SFMBT1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2676518 (gene symbol: SFMBT1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea None None 3.2e-20 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2676518__gene_symbol__sfmbt1__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12962167 chr3:53033115 3 53033115 SFMBT1 Island 0.0027 None 5.3e-19 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0732612 0.00823438 6.399605e-19 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 2.5 0.281 8e-19 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.0011 None 3.6e-18 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0692363 0.00823676 4.637719e-17 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.067217 0.0082379 3.636119e-16 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19008809 chr3:53080682 3 53080682 SFMBT1 Island 0.00041 None 3.9e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.027 0.00287 8.9e-16 None 32795589_Kyung-WK_eosinophilia_discovery Tajuddin SM HANDLS 31426852 2019-08-19 Age EFO_0001799 In African American individuals Table 2, Table S1 DNA methylation Age Sex, ancestry (other), socioeconomic position, cell composition (reference based) Beta Values years Illumina HumanMethylationEPIC Whole Blood Not all sites reported 237 1 Adults Both African cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.022 0.0028 0.0000000000000071 None 31426852_Tajuddin-SM_age_in_african_american_individuals Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0641027 0.00823959 0.000000000000007744156 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0639808 0.00823965 0.000000000000008703467 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0639046 0.0082397 0.000000000000009361849 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.0636669 0.00823982 0.00000000000001174653 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0633539 0.00823999 0.00000000000001581782 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0633447 0.00823999 0.00000000000001595642 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09744376 chr3:53080176 3 53080176 SFMBT1 Island 0.00038 None 0.000000000000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.062411 0.00824048 0.00000000000003843012 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island 0.0618796 0.00824075 0.00000000000006301851 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.106967 0.0143363 0.0000000000000904743 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.060513 0.00824144 0.000000000000220611 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0604415 0.00824148 0.0000000000002353866 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0603214 0.00824154 0.0000000000002624162 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0601212 0.00824164 0.0000000000003143734 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0600267 0.00824168 0.000000000000342317 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.059762 0.00824181 0.0000000000004341326 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27565382 chr3:53032988 3 53032988 SFMBT1 Island 0.0023 None 0.00000000000069 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island 0.0591028 0.00824214 0.0000000000007811698 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0018 None 0.000000000001 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0588124 0.00824228 0.000000000001009897 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15956490 chr3:53032818 3 53032818 SFMBT1 Island 0.0019 None 0.0000000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0580233 0.00824266 0.000000000002016464 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0572879 0.00824301 0.00000000000381024 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0571055 0.0082431 0.000000000004456114 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0564691 0.0082434 0.00000000000766687 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.014 0.00184 0.0000000000089 None 32795589_Kyung-WK_atopy_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0097 0.00134 0.000000000012 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg09744376 chr3:53080176 3 53080176 SFMBT1 Island 1.628116 0.2401 0.000000000012 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0079 0.0012 0.000000000018 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.189713 0.028476 0.0000000000277466 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Petersen A-K KORA F4 24014485 2013-09-06 M32388_dodecanedioate EFO_0004727, EFO_0004725 no snps model Table S2 M32388_dodecanedioate DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.89 0.141 0.000000000029 None 24014485_Petersen-A-K_m32388_dodecanedioate_no_snps_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0545992 0.00824426 0.00000000003649689 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Petersen A-K KORA F4 24014485 2013-09-06 M32388_dodecanedioate EFO_0004727, EFO_0004725 snps as covariates model Table S4 M32388_dodecanedioate DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.89 0.148 0.000000000048 None 24014485_Petersen-A-K_m32388_dodecanedioate_snps_as_covariates_model Florath I - 24163245 2014-03-01 Age EFO_0000246 - Table 2 DNA methylation Age Sex, smoking behaviour, diabetes mellitus, cardiovascular disease, stroke, cancer and technical covariates Beta values Years Illumina HumanMethylation450 Whole blood - 498 1 62 Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.01073 0.0016 0.0000000000526 - 24163245_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0540336 0.00824451 0.0000000000579282 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0538377 0.0082446 0.00000000006790443 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24616795 chr3:53032891 3 53032891 SFMBT1 Island 0.0021 None 0.000000000086 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0532368 0.00824486 0.0000000001101813 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.039 0.00598 0.00000000012 None Robert-F-Hillary_Incident_COPD_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.238176 0.0370346 0.0000000001297716 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.055455 0.00862219 0.000000000130129 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0924966 0.0143955 0.0000000001356169 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0911863 0.0142442 0.0000000001583864 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21126969 chr3:53030684 3 53030684 SFMBT1 North shelf 0.01724 0.00255 0.00000000016 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0527249 0.00824509 0.0000000001657301 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Johnson KC - 28693600 2017-07-10 Age EFO_0000246 - Additional file 3 DNA methylation Age Body mass index, parity and cell counts M values years Illumina HumanMethylation450 Breast - 100 1 37.2 Females European,African,Admixed cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0169 0.0026 0.000000000168 - 28693600_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0917474 0.0143645 0.0000000001741484 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0524649 0.0082452 0.0000000002036193 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0651885 0.0102917 0.0000000002457434 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Battram T GEO 29383109 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE101961 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Breast None 121 1 Adults Females European, African cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0008 0.00011 0.00000000025 None 29383109_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse101961 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg26401492 chr3:53003348 3 53003348 SFMBT1 Open sea -0.02526 0.004 0.000000000289 - 23334450_rheumatoid_arthritis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg17761990 chr3:53042940 3 53042940 SFMBT1 Open sea 0.01947 0.00295 0.0000000004 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21126969 chr3:53030684 3 53030684 SFMBT1 North shelf -0.0018 0.0003 0.00000000076 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0626818 0.0102268 0.000000000905971 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0501978 0.00824616 0.000000001176074 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0496281 0.0082464 0.0000000018062 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 1.7 0.281 0.0000000023 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.048708 0.00824677 0.000000003575895 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0843378 0.0143305 0.000000004062512 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0485022 0.00824685 0.000000004159109 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.00088 0.00015 0.0000000042 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0484046 0.00824689 0.000000004467128 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.058614 0.00999447 0.000000004597915 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0482298 0.00824696 0.000000005075126 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0818894 0.0140654 0.000000005935609 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0479141 0.00824709 0.000000006383783 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0476366 0.0082472 0.000000007800309 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0571316 0.0099197 0.000000008610143 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0474515 0.00824727 0.00000000891049 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0574685 0.0100019 0.000000009332456 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0472702 0.00824734 0.00000001014643 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0472573 0.00824735 0.00000001024013 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0570617 0.00998967 0.0000000113773 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0470908 0.00824741 0.00000001153258 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0470905 0.00824741 0.00000001153433 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0568486 0.010018 0.0000000141592 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0467854 0.00824753 0.00000001432511 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0467681 0.00824754 0.00000001450234 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0566814 0.00999815 0.00000001461826 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 3.6 0.631 0.000000017 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07884673 chr3:53033167 3 53033167 SFMBT1 South shore 0.002 None 0.000000019 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg22581676 chr3:53080960 3 53080960 SFMBT1 Island 0.011 0.00172 0.000000019 None 32795589_Kyung-WK_eosinophilia_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.0246 0.00421 0.000000021 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0461222 0.00824778 0.00000002283803 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg05527877 chr3:53075834 3 53075834 SFMBT1 North shelf -0.01449 0.0026 0.0000000231 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0460664 0.00824781 0.00000002374517 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11100324 chr3:53003497 3 53003497 SFMBT1 Open sea -0.011 0.002 0.000000025 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea -0.0459596 0.00824785 0.00000002557967 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0459087 0.00824787 0.00000002650147 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0556867 0.0100108 0.00000002703259 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27127091 chr3:53036929 3 53036929 SFMBT1 South shelf 0.03292 0.00569 0.000000029 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0553622 0.00998602 0.0000000300791 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0456939 0.00824795 0.00000003076191 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island 0.0456641 0.00824796 0.000000031402 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.0084 0.0015 0.000000033 None 33450751_Mulder-RH_sex_discovery Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg09744376 chr3:53080176 3 53080176 SFMBT1 Island - - 0.0000000354 - 26857698_primary_sjogrens_syndrome_whole_blood Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.198838 0.0360788 0.00000003614523 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14149609 chr3:53032638 3 53032638 SFMBT1 North shore 0.00095 None 0.000000038 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0453297 0.00824808 0.00000003954618 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0453025 0.00824809 0.00000004029345 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Tajuddin SM HANDLS 31426852 2019-08-19 Age EFO_0001799 In white individuals Table 2, Table S1 DNA methylation Age Sex, ancestry (other), socioeconomic position, cell composition (reference based) Beta Values years Illumina HumanMethylationEPIC Whole Blood Not all sites reported 233 1 Adults Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.018 0.0033 0.000000043 None 31426852_Tajuddin-SM_age_in_white_individuals Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0448436 0.00824827 0.00000005513511 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0513148 0.00944719 0.00000005669506 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0447374 0.0082483 0.00000005925912 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0445804 0.00824836 0.00000006591193 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Battram T GEO 30291105 2020-11-01 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE113904 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Colon, rectum None 232 1 Adults Both Unclear cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.00058 0.0001 0.000000066 None 30291105_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse113904 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.0034 None 0.000000067 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24616795 chr3:53032891 3 53032891 SFMBT1 Island -0.00042 0.000077 0.000000069 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24616795 chr3:53032891 3 53032891 SFMBT1 Island -0.00425 0.00076 0.000000073 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0443147 0.00824846 0.00000007884855 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.046427 0.00864868 0.00000008077865 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0442596 0.00824848 0.00000008182292 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea None None 0.000000083 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea None None 0.000000084 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0769074 0.0143709 0.00000008848633 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea -0.0440485 0.00824856 0.00000009425361 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0547486 0.0102677 0.00000009851053 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0478791 0.00899183 0.0000001025888 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0438307 0.00824864 0.0000001089957 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.053561 0.0101016 0.0000001160704 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0436897 0.00824869 0.0000001197071 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0759754 0.0143929 0.0000001319959 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0433982 0.00824879 0.0000001451685 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0531156 0.010115 0.0000001532618 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 2.2 0.421 0.00000016 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26401492 chr3:53003348 3 53003348 SFMBT1 Open sea -0.0013 0.00024 0.00000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.043058 0.00824891 0.0000001815243 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0521317 0.00998925 0.0000001825689 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.052268 0.0100157 0.0000001827365 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0428857 0.00824898 0.0000002031531 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0466078 0.00897443 0.0000002092453 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0426071 0.00824907 0.000000243483 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0426037 0.00824907 0.0000002440255 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0425963 0.00824908 0.0000002452048 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09744376 chr3:53080176 3 53080176 SFMBT1 Island 0.01357 0.00254 0.00000026 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.0424891 0.00824912 0.0000002628108 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0424735 0.00824912 0.0000002654765 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0422825 0.00824919 0.0000003002672 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0421819 0.00824922 0.0000003203296 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0421768 0.00824922 0.0000003213771 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.0421461 0.00824924 0.0000003277801 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0420338 0.00824927 0.0000003522384 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.0419795 0.00824929 0.0000003646725 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.0419415 0.00824931 0.0000003736304 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22049472 chr3:53081507 3 53081507 SFMBT1 South shore -0.0419277 0.00824931 0.0000003769458 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0498871 0.00982828 0.0000003904383 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0504537 0.00995061 0.0000004017829 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.0417471 0.00824937 0.0000004229093 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0506802 0.0100217 0.0000004309343 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.177289 0.0351567 0.000000463144 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0414193 0.00824949 0.0000005205009 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0413386 0.00824951 0.0000005476723 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.050143 0.010012 0.0000005555559 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.16732 0.0334359 0.0000005664349 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.040989 0.00824963 0.000000682052 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0709832 0.0142904 0.0000006869689 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island -0.0409667 0.00824964 0.0000006916082 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0429748 0.00865424 0.0000006920574 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.00014403 2.9e-05 0.000000697 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0409403 0.00824965 0.0000007030935 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0709549 0.0142987 0.0000007043879 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0409346 0.00824965 0.0000007056224 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0408397 0.00824968 0.0000007486265 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0408003 0.0082497 0.0000007671983 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24775474 chr3:53081493 3 53081493 SFMBT1 South shore 0.156181 0.0315961 0.0000007763406 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0427789 0.00865757 0.0000007849566 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.040691 0.00824973 0.000000821131 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0491276 0.00998035 0.0000008640369 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22049472 chr3:53081507 3 53081507 SFMBT1 South shore 0.186871 0.038009 0.0000008891147 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0490097 0.00999409 0.0000009497332 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0404327 0.00824982 0.0000009635035 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04504284 chr3:53079796 3 53079796 SFMBT1 Island -0.000056 0.000012 0.000001 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.201734 0.041323 0.00000105965 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0401873 0.0082499 0.000001120523 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.040059 0.00824994 0.000001212184 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0399831 0.00824997 0.000001269723 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH29 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH29 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.039884 0.00825 0.000001348833 A0A0C4DH29 41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0398818 0.00825 0.000001350652 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0418929 0.00867815 0.000001397185 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0435408 0.00902406 0.00000141438 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0397171 0.00825006 0.000001492929 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.0396641 0.00825007 0.000001541731 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0396291 0.00825009 0.000001574747 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea 0.0027 0.00057 0.0000016 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0673546 0.014038 0.000001618354 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea -0.0395654 0.00825011 0.000001636686 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0415982 0.00867746 0.000001652402 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.039522 0.00825012 0.000001680137 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12962167 chr3:53033115 3 53033115 SFMBT1 Island -0.0012 0.00026 0.0000017 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Neumann A ALSPAC, GENR, INMA, NEST, PREDO 33184255 2020-11-12 ADHD EFO_0003888 At birth Supplementary data adhd_birth_results ADHD DNA methylation maternal age, education level, smoking, gestational age, sex, cell composition (reference based) ADHD score Beta Values Illumina HumanMethylation450 Cord Blood None 2477 5 Infants Both European, African cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea -2.325 1.883 0.0000019 None 33184255_Neumann-A_adhd_at_birth Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0476725 0.0100136 0.000001947186 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0392586 0.00825021 0.000001969023 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0571132 0.0120063 0.000001984183 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0680223 0.0143142 0.000002032407 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0391306 0.00825025 0.000002125988 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0465441 0.00982079 0.000002164276 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.15108 0.031887 0.000002175597 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0389743 0.0082503 0.000002334142 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.158129 0.0335606 0.000002475281 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.03882 0.00825035 0.000002558634 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0671216 0.0143155 0.000002773895 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.156235 0.0333447 0.000002814606 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0671953 0.0143612 0.000002909441 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0385901 0.00825042 0.000002931928 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0385037 0.00825045 0.000003085359 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0398726 0.00856525 0.000003265749 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0383597 0.00825049 0.000003358304 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17177069 chr3:52964898 3 52964898 SFMBT1 Open sea 0.0383051 0.00825051 0.000003467665 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.0382983 0.00825051 0.000003481612 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19373170 chr3:53079105 3 53079105 SFMBT1 Island -0.00018 0.000039 0.000004 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore -0.0380254 0.0082506 0.000004084043 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0379857 0.00825061 0.000004179539 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11100324 chr3:53003497 3 53003497 SFMBT1 Open sea 0.02158 0.00455 0.0000042 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.036 0.00793 0.0000042 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0379417 0.00825063 0.000004288044 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0393082 0.00855012 0.000004313981 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0452552 0.0098462 0.000004338331 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0454011 0.00988062 0.000004364436 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0420923 0.00917244 0.000004490795 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.065946 0.0143752 0.000004523682 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0457987 0.0100059 0.000004751235 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.00046254 0.00010062 0.00000481 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0376611 0.00825071 0.00000504539 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ITPRIPL1 protein levels (SeqId = 9221-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITPRIPL1 protein levels (SeqId = 9221-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.73 0.161 0.0000052 None Gadd-DA_itpripl1_protein_levels__seqid___9221-6__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14017966 chr3:53070557 3 53070557 SFMBT1 Open sea -0.223291 0.0490891 0.000005433056 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 1.3 0.293 0.0000055 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0429628 0.00946799 0.000005732592 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0374239 0.00825079 0.000005784224 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0374021 0.00825079 0.000005856977 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -1.1 0.246 0.0000063 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0372046 0.00825086 0.000006558243 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0371817 0.00825086 0.000006644667 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0016 0.00035 0.000007 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0370549 0.0082509 0.000007142471 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0370511 0.0082509 0.000007158192 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.063171 0.0140906 0.000007409374 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0643745 0.014388 0.00000772836 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.038916 0.00870165 0.000007798137 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.04384 0.00981333 0.000007976982 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0385515 0.0086328 0.000008040549 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0368309 0.00825097 0.000008110797 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea -0.0378819 0.00849657 0.000008315325 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0458447 0.0102893 0.000008428623 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22049472 chr3:53081507 3 53081507 SFMBT1 South shore 0.0377314 0.00847303 0.000008525812 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0366824 0.00825101 0.000008820451 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GNAI1 protein levels (SeqId = 19271-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNAI1 protein levels (SeqId = 19271-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide-binding protein G(i) subunit alpha-1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.712 0.161 0.0000093 None Gadd-DA_gnai1_protein_levels__seqid___19271-64__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22049472 chr3:53081507 3 53081507 SFMBT1 South shore 0.0375887 0.00848403 0.000009468397 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.037 0.00844 0.00001 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.159634 0.0361728 0.00001025261 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.036362 0.00825111 0.00001055935 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore -0.0363419 0.00825112 0.00001067902 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0632253 0.0143843 0.00001113338 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.0362052 0.00825116 0.00001152504 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0361333 0.00825118 0.00001199555 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MTRF1L protein levels (SeqId = 11134-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTRF1L protein levels (SeqId = 11134-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptide chain release factor 1-like, mitochondrial 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.699 0.159 0.000012 None Gadd-DA_mtrf1l_protein_levels__seqid___11134-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11100324 chr3:53003497 3 53003497 SFMBT1 Open sea 0.0360649 0.0082512 0.0000124605 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0629154 0.0144053 0.00001265254 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_4 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg19373170 chr3:53079105 3 53079105 SFMBT1 Island -0.267141 0.0612 0.0000128 - 27105112_hiv_infection_neutrophils Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0359964 0.00825122 0.00001294302 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea 0.0359433 0.00825124 0.00001332902 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0359259 0.00825124 0.00001345843 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0376255 0.00865371 0.00001383703 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0626253 0.014405 0.00001386542 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0608797 0.0140035 0.00001386559 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 1.7 0.383 0.000014 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island -0.0357478 0.00825129 0.00001484833 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 EFNA3 protein levels (SeqId = 14153-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFNA3 protein levels (SeqId = 14153-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ephrin-A3 774 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.66 0.153 0.000016 None Gadd-DA_efna3_protein_levels__seqid___14153-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LAMP1 protein levels (SeqId = 16902-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LAMP1 protein levels (SeqId = 16902-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysosome-associated membrane glycoprotein 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.69 0.161 0.000016 None Gadd-DA_lamp1_protein_levels__seqid___16902-17__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0621887 0.0144112 0.00001604309 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0355522 0.00825135 0.00001653185 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.0042 0.00097 0.000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0354728 0.00825138 0.00001726696 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0354389 0.00825139 0.0000175896 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0354084 0.00825139 0.0000178849 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0353836 0.0082514 0.00001812882 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island 0.0353316 0.00825142 0.00001865012 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0364843 0.00852405 0.00001879476 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea -0.0352772 0.00825143 0.00001921032 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore -0.0352639 0.00825144 0.00001934938 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0351519 0.00825147 0.00002056256 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0365817 0.00858769 0.00002059028 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0351468 0.00825147 0.00002062005 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MMEL1 protein levels (SeqId = 3627-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MMEL1 protein levels (SeqId = 3627-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Membrane metallo-endopeptidase-like 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.68 0.16 0.000021 None Gadd-DA_mmel1_protein_levels__seqid___3627-71__somascan_protein_measurement Fernandez-Jimenez N Pregnancy And Childhood Epigenetics (PACE) None None maternal pre-pregnancy body mass index EFO_0004340 inverse variance-weighted fixed effects meta-analysis adjusted by cellular heterogeneity https://doi.org/10.5281/zenodo.7314534 DNA methylation maternal pre-pregnancy body mass index Cell composition (reference free), maternal age, parity, maternal education, maternal smoking Beta values kg/m2 Illumina HumanMethylation450 Placenta None 2631 10 Infants Both European, Unclear cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea 0.00015 0.000034 0.000021 None Fernandez-Jimenez-N_maternal_pre-pregnancy_body_mass_index_inverse_variance-weighted_fixed_effects_meta-analysis_adjusted_by_cellular_heterogeneity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0608759 0.0143343 0.00002181121 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg27127091 chr3:53036929 3 53036929 SFMBT1 South shelf -0.933296 0.22 0.0000222 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0350085 0.00825151 0.00002222227 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0348458 0.00825156 0.00002425961 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CCL17 protein levels (SeqId = 3519-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCL17 protein levels (SeqId = 3519-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-C motif chemokine 17 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.159 0.000025 None Gadd-DA_ccl17_protein_levels__seqid___3519-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0347486 0.00825159 0.00002556003 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 N6AMT1 protein levels (SeqId = 11096-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 N6AMT1 protein levels (SeqId = 11096-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methyltransferase N6AMT1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.68 0.161 0.000026 None Gadd-DA_n6amt1_protein_levels__seqid___11096-57__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0364302 0.00866096 0.00002611737 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0360808 0.0085809 0.00002628862 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 DIRAS1 protein levels (SeqId = 17793-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DIRAS1 protein levels (SeqId = 17793-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GTP-binding protein Di-Ras1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.16 0.000027 None Gadd-DA_diras1_protein_levels__seqid___17793-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PLXDC2 protein levels (SeqId = 11342-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLXDC2 protein levels (SeqId = 11342-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Plexin domain-containing protein 2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.16 0.000027 None Gadd-DA_plxdc2_protein_levels__seqid___11342-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SOS1 protein levels (SeqId = 9923-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SOS1 protein levels (SeqId = 9923-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Son of sevenless homolog 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.16 0.000029 None Gadd-DA_sos1_protein_levels__seqid___9923-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.0354142 0.00847442 0.00002945593 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12962167 chr3:53033115 3 53033115 SFMBT1 Island 0.0063 None 0.00003 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea -0.0036 0.00085 0.000031 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 MATK protein levels (SeqId = 3823-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MATK protein levels (SeqId = 3823-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Megakaryocyte-associated tyrosine-protein kinase 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.16 0.000031 None Gadd-DA_matk_protein_levels__seqid___3823-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPOCK3 protein levels (SeqId = 9906-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPOCK3 protein levels (SeqId = 9906-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Testican-3 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.161 0.000031 None Gadd-DA_spock3_protein_levels__seqid___9906-21__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea 0.034383 0.00825169 0.00003107066 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0343377 0.0082517 0.00003182605 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FHIT protein levels (SeqId = 9826-135) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FHIT protein levels (SeqId = 9826-135) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bis(5'-adenosyl)-triphosphatase 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.161 0.000032 None Gadd-DA_fhit_protein_levels__seqid___9826-135__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NCK1 protein levels (SeqId = 5014-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NCK1 protein levels (SeqId = 5014-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytoplasmic protein NCK1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.67 0.161 0.000033 None Gadd-DA_nck1_protein_levels__seqid___5014-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.0342031 0.00825174 0.00003417951 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0374119 0.00902721 0.00003426919 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0358563 0.00865188 0.00003427095 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GAGE2D protein levels (SeqId = 18273-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAGE2D protein levels (SeqId = 18273-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: G antigen 2D 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.665 0.161 0.000035 None Gadd-DA_gage2d_protein_levels__seqid___18273-14__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.131881 0.031867 0.00003512691 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0372422 0.00900443 0.00003553992 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island -0.0365257 0.00883326 0.00003569051 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Cronjé HT Prospective Urban and Rural Epidemiology study 31910897 2020-01-07 Alcohol consumption EFO_0004329, NCIT_C16273 None Additional file 2a DNA methylation Alcohol consumption Age, body mass index, smoking, cell composition (reference based), batch effects Beta Values grams per day Illumina HumanMethylationEPIC Whole blood None 108 1 Adults Males African cg03172807 chr3:52939018 3 52939018 SFMBT1 Open sea -0.00025 0.000057 0.000036 None 31910897_Cronjé-HT_alcohol_consumption Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 0.0340865 0.00825177 0.00003634989 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 IL3 protein levels (SeqId = 4717-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL3 protein levels (SeqId = 4717-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-3 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.16 0.000037 None Gadd-DA_il3_protein_levels__seqid___4717-55__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea -0.0424011 0.0102891 0.0000379317 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SRA1 protein levels (SeqId = 18220-141) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SRA1 protein levels (SeqId = 18220-141) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Steroid receptor RNA activator 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.16 0.000038 None Gadd-DA_sra1_protein_levels__seqid___18220-141__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGFBP3 protein levels (SeqId = 11219-95) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGFBP3 protein levels (SeqId = 11219-95) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor-binding protein 3 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.16 0.000038 None Gadd-DA_fgfbp3_protein_levels__seqid___11219-95__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CASP2 protein levels (SeqId = 4904-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CASP2 protein levels (SeqId = 4904-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Caspase-2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.161 0.000038 None Gadd-DA_casp2_protein_levels__seqid___4904-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0339857 0.0082518 0.00003833117 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26401492 chr3:53003348 3 53003348 SFMBT1 Open sea 0.0014 None 0.000039 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19008809 chr3:53080682 3 53080682 SFMBT1 Island 0.0338845 0.00825183 0.00004042273 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0390672 0.0095211 0.00004096314 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PDCL2 protein levels (SeqId = 14192-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDCL2 protein levels (SeqId = 14192-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosducin-like protein 2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.161 0.000041 None Gadd-DA_pdcl2_protein_levels__seqid___14192-31__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Neutrophils Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 Neutrophils - 60 1 46.5 Males European cg09744376 chr3:53080176 3 53080176 SFMBT1 Island 0.304066 0.0741 0.0000411 - 27105112_hiv_infection_neutrophils Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0370236 0.00902678 0.00004126428 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GAD1 protein levels (SeqId = 11280-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAD1 protein levels (SeqId = 11280-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutamate decarboxylase 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.161 0.000042 None Gadd-DA_gad1_protein_levels__seqid___11280-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0338107 0.00825185 0.00004201622 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SYNE2 protein levels (SeqId = 9789-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYNE2 protein levels (SeqId = 9789-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nesprin-2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.161 0.000044 None Gadd-DA_syne2_protein_levels__seqid___9789-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IRAK4 protein levels (SeqId = 18162-167) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IRAK4 protein levels (SeqId = 18162-167) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-1 receptor-associated kinase 4 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.65 0.16 0.000045 None Gadd-DA_irak4_protein_levels__seqid___18162-167__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0336502 0.0082519 0.00004568969 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LIN7B protein levels (SeqId = 15612-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LIN7B protein levels (SeqId = 15612-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein lin-7 homolog B 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.66 0.161 0.000046 None Gadd-DA_lin7b_protein_levels__seqid___15612-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CALB1 protein levels (SeqId = 9918-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CALB1 protein levels (SeqId = 9918-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calbindin 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.65 0.16 0.000046 None Gadd-DA_calb1_protein_levels__seqid___9918-23__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0347606 0.00852992 0.00004622837 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22049472 chr3:53081507 3 53081507 SFMBT1 South shore -0.0345617 0.0084882 0.00004690888 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0586298 0.0144049 0.0000472325 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea -0.0367376 0.0090264 0.00004725731 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CDK8 protein levels (SeqId = 3359-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CDK8 protein levels (SeqId = 3359-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-dependent kinase 8|Cyclin-C 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.65 0.161 0.000048 None Gadd-DA_cdk8_protein_levels__seqid___3359-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03607117 chr3:53080440 3 53080440 SFMBT1 Island -0.0335514 0.00825192 0.00004810018 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 BDNF protein levels (SeqId = 2421-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BDNF protein levels (SeqId = 2421-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Brain-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.649 0.16 0.00005 None Gadd-DA_bdnf_protein_levels__seqid___2421-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0334705 0.00825195 0.0000501617 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.0405433 0.0100108 0.00005149497 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea -0.0344982 0.00851827 0.00005150159 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea 0.0334118 0.00825196 0.00005171115 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05229308 chr3:53044407 3 53044407 SFMBT1 Open sea 0.0333757 0.00825197 0.00005268586 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0401706 0.00994776 0.00005414812 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PCMT1 protein levels (SeqId = 18160-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PCMT1 protein levels (SeqId = 18160-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.65 0.161 0.000055 None Gadd-DA_pcmt1_protein_levels__seqid___18160-2__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.181233 0.0450979 0.00005876589 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea -0.0331584 0.00825203 0.00005893593 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0348858 0.00870196 0.00006128996 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0330364 0.00825206 0.00006274442 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 RNF148 protein levels (SeqId = 9955-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF148 protein levels (SeqId = 9955-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RING finger protein 148 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000063 None Gadd-DA_rnf148_protein_levels__seqid___9955-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PDGFD protein levels (SeqId = 17140-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PDGFD protein levels (SeqId = 17140-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Platelet-derived growth factor D 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000063 None Gadd-DA_pdgfd_protein_levels__seqid___17140-57__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg26850469 chr3:53051694 3 53051694 SFMBT1 Open sea 1.1 0.287 0.000064 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea 0.032976 0.00825208 0.00006471469 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 UBE2G1 protein levels (SeqId = 17158-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2G1 protein levels (SeqId = 17158-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 G1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000065 None Gadd-DA_ube2g1_protein_levels__seqid___17158-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CNN2 protein levels (SeqId = 18877-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNN2 protein levels (SeqId = 18877-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Calponin-2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000065 None Gadd-DA_cnn2_protein_levels__seqid___18877-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 P4HB protein levels (SeqId = 4278-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 P4HB protein levels (SeqId = 4278-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein disulfide-isomerase 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000065 None Gadd-DA_p4hb_protein_levels__seqid___4278-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYSM1 protein levels (SeqId = 11536-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYSM1 protein levels (SeqId = 11536-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone H2A deubiquitinase MYSM1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000067 None Gadd-DA_mysm1_protein_levels__seqid___11536-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0342504 0.0085904 0.00006722429 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q16610 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q16610 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0328916 0.0082521 0.00006756587 Q16610 41361833_Josephine_Robertson_Q16610_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FGF20 protein levels (SeqId = 2763-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF20 protein levels (SeqId = 2763-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 20 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000068 None Gadd-DA_fgf20_protein_levels__seqid___2763-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.0328521 0.00825211 0.0000689412 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 IL20RA protein levels (SeqId = 5085-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL20RA protein levels (SeqId = 5085-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-20 receptor subunit alpha 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000069 None Gadd-DA_il20ra_protein_levels__seqid___5085-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCNA1 protein levels (SeqId = 15319-226) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCNA1 protein levels (SeqId = 15319-226) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclin-A1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000069 None Gadd-DA_ccna1_protein_levels__seqid___15319-226__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNPC3 protein levels (SeqId = 12814-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNPC3 protein levels (SeqId = 12814-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RNA-binding region-containing protein 3 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.639 0.161 0.00007 None Gadd-DA_rnpc3_protein_levels__seqid___12814-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBBP6 protein levels (SeqId = 9887-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBBP6 protein levels (SeqId = 9887-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RBBP6 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000072 None Gadd-DA_rbbp6_protein_levels__seqid___9887-40__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea -0.179677 0.0452659 0.00007233969 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island -0.0337223 0.00849698 0.00007259946 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 RGS1 protein levels (SeqId = 18945-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RGS1 protein levels (SeqId = 18945-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Regulator of G-protein signaling 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000074 None Gadd-DA_rgs1_protein_levels__seqid___18945-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TSLP protein levels (SeqId = 3010-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TSLP protein levels (SeqId = 3010-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thymic stromal lymphopoietin 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.16 0.000074 None Gadd-DA_tslp_protein_levels__seqid___3010-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRR16 protein levels (SeqId = 10621-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRR16 protein levels (SeqId = 10621-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein Largen 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000074 None Gadd-DA_prr16_protein_levels__seqid___10621-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24616795 chr3:53032891 3 53032891 SFMBT1 Island 0.0327086 0.00825215 0.00007416556 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 OBP2A protein levels (SeqId = 6526-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OBP2A protein levels (SeqId = 6526-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Odorant-binding protein 2a 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.634 0.16 0.000075 None Gadd-DA_obp2a_protein_levels__seqid___6526-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HTATIP2 protein levels (SeqId = 7753-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HTATIP2 protein levels (SeqId = 7753-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oxidoreductase HTATIP2 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.000076 None Gadd-DA_htatip2_protein_levels__seqid___7753-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HDAC8 protein levels (SeqId = 2859-69) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDAC8 protein levels (SeqId = 2859-69) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone deacetylase 8 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.64 0.161 0.000076 None Gadd-DA_hdac8_protein_levels__seqid___2859-69__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04503182 chr3:53078218 3 53078218 SFMBT1 North shore 0.00061 0.00016 0.00008 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 KIAA1467 protein levels (SeqId = 9981-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA1467 protein levels (SeqId = 9981-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein FAM234B 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.00008 None Gadd-DA_kiaa1467_protein_levels__seqid___9981-18__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17177069 chr3:52964898 3 52964898 SFMBT1 Open sea 0.0325405 0.0082522 0.00008075922 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GCNT2 protein levels (SeqId = 7143-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GCNT2 protein levels (SeqId = 7143-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.000081 None Gadd-DA_gcnt2_protein_levels__seqid___7143-9__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island -0.0325215 0.0082522 0.00008153774 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18571112 chr3:52968878 3 52968878 SFMBT1 Open sea 0.0356892 0.00905633 0.0000815866 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 DNAJC11 protein levels (SeqId = 9783-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DNAJC11 protein levels (SeqId = 9783-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DnaJ homolog subfamily C member 11 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.000083 None Gadd-DA_dnajc11_protein_levels__seqid___9783-75__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0565639 0.0143744 0.00008356402 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 CCDC134 protein levels (SeqId = 15300-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCDC134 protein levels (SeqId = 15300-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coiled-coil domain-containing protein 134 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.000084 None Gadd-DA_ccdc134_protein_levels__seqid___15300-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00325548 chr3:52947163 3 52947163 SFMBT1 Open sea 0.0371782 0.00945283 0.00008427154 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18490867 chr3:53056778 3 53056778 SFMBT1 Open sea 0.0324477 0.00825222 0.00008462921 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HDHD3 protein levels (SeqId = 19482-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HDHD3 protein levels (SeqId = 19482-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Haloacid dehalogenase-like hydrolase domain-containing protein 3 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.000087 None Gadd-DA_hdhd3_protein_levels__seqid___19482-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NDUFB8 protein levels (SeqId = 9800-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NDUFB8 protein levels (SeqId = 9800-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.631 0.161 0.000088 None Gadd-DA_ndufb8_protein_levels__seqid___9800-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NFKBID protein levels (SeqId = 19123-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NFKBID protein levels (SeqId = 19123-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NF-kappa-B inhibitor delta 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.000089 None Gadd-DA_nfkbid_protein_levels__seqid___19123-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00557943 chr3:53017376 3 53017376 SFMBT1 Open sea -0.032335 0.00825225 0.00008957266 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SARS2 protein levels (SeqId = 12348-46) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SARS2 protein levels (SeqId = 12348-46) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine--tRNA ligase, mitochondrial 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.00009 None Gadd-DA_sars2_protein_levels__seqid___12348-46__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03185935 chr3:53065253 3 53065253 SFMBT1 Open sea -0.0323074 0.00825226 0.00009082218 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10299061 chr3:53078990 3 53078990 SFMBT1 Island 0.0322867 0.00825227 0.00009177282 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 BSG protein levels (SeqId = 3585-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BSG protein levels (SeqId = 3585-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Basigin 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.000092 None Gadd-DA_bsg_protein_levels__seqid___3585-54__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.181652 0.0464914 0.00009371918 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea -0.241687 0.0618805 0.00009431105 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea -0.0322292 0.00825228 0.00009445395 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 KLK5 protein levels (SeqId = 3201-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLK5 protein levels (SeqId = 3201-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kallikrein-5 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.16 0.000095 None Gadd-DA_klk5_protein_levels__seqid___3201-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AIF1 protein levels (SeqId = 2849-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AIF1 protein levels (SeqId = 2849-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Allograft inflammatory factor 1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.000096 None Gadd-DA_aif1_protein_levels__seqid___2849-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03891126 chr3:53040106 3 53040106 SFMBT1 Open sea 0.0333464 0.00854951 0.00009646944 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03845193 chr3:53017744 3 53017744 SFMBT1 Open sea 0.03907 0.0100203 0.00009699293 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 BCL2A1 protein levels (SeqId = 3413-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCL2A1 protein levels (SeqId = 3413-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bcl-2-related protein A1 774 1 Adults (18-65 years) Both European cg24445507 chr3:53044901 3 53044901 SFMBT1 Open sea -0.63 0.161 0.000098 None Gadd-DA_bcl2a1_protein_levels__seqid___3413-50__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg22581676 chr3:53080960 3 53080960 SFMBT1 Island 0.036 0.0093 0.000099 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09977701 chr3:53060719 3 53060719 SFMBT1 Open sea -0.032128 0.00825231 0.00009936476 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1