author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea -0.0026 0.00027 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 3187 2 65.7 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.04 0.004 0 - 28173150_serum_triglycerides_discovery_and_replication Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 3187 2 65.7 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.043 0.004 0 - 28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0033 0.00018 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.013 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.00095 0.000074 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.58328 0.00779 1.6000000000000001e-144 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.499254 0.0220287 4.374484e-112 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.28741 0.00648 3.3e-103 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47579 0.0219128 3.702598e-103 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.451347 0.0211308 6.176528999999999e-100 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.458385 0.0219978 2.919451e-95 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.427507 0.02111 3.8242559999999996e-90 None 39706196_Hannah-M.-Smith_bmi_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 1.4e-86 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.417194 0.0211051 5.046754e-86 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.158033 0.00815282 1.13823e-82 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -3 0.157 3e-79 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.14565 0.0046 2.5000000000000003e-78 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.29249 0.00941 4.4e-77 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.05869 0.0019 1.5e-76 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 7.4e-70 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.25131 0.00953 7e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.145358 0.00860095 1.7895469999999999e-63 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.134644 0.00826668 3.997652e-59 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.130937 0.00818549 4.123052e-57 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.129382 0.00826165 7.832184e-55 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.127128 0.00818958 6.488546e-54 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.125344 0.00819146 1.8905040000000003e-52 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.125566 0.008285 1.702994e-51 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.133469 0.00883171 3.262635e-51 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.124283 0.00829138 2.0330109999999999e-50 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.11822 0.00819867 8.162084e-47 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.117316 0.00816166 1.560992e-46 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 6.1999999999999994e-46 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.114277 0.00843034 1.311076e-41 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.111791 0.00830255 4.429069e-41 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Petersen A-K KORA F4 24014485 2013-09-06 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* EFO_0004727, EFO_0004725 no snps model Table S2 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.98 0.13 2.7e-40 None 24014485_Petersen-A-K_m37202_4-androsten-3betacomma17beta-diol_disulfate_1__no_snps_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg15441006 chr4:139110589 4 139110589 SLC7A11 Open sea -0.12183 0.00726 1.4999999999999998e-39 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.107974 0.0082083 2.6854760000000002e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.107648 0.00820859 4.5367410000000003e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.08466 0.0051 4.6e-39 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Petersen A-K KORA F4 24014485 2013-09-06 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* EFO_0004727, EFO_0004725 snps as covariates model Table S4 M37202_4-androsten-3betacomma17beta-diol_disulfate_1* DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.98 0.13 6.8e-39 None 24014485_Petersen-A-K_m37202_4-androsten-3betacomma17beta-diol_disulfate_1__snps_as_covariates_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.287347 0.022129 2.216984e-38 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.106469 0.00820964 2.9865159999999997e-38 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.106226 0.00820986 4.3913579999999995e-38 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.269361 0.0210361 2.251918e-37 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.106393 0.0084802 6.397468e-36 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.102723 0.00821289 1.032655e-35 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.102549 0.00821304 1.348508e-35 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.102856 0.0083257 6.903656e-35 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.102852 0.00832993 7.502679e-35 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.108469 0.00882648 1.535676e-34 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.100861 0.00821447 1.7469739999999998e-34 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.100641 0.00821465 2.428334e-34 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.100432 0.00821483 3.322233e-34 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01309945 chr4:139126892 4 139126892 SLC7A11 Open sea -0.02683 0.0018 6.5e-34 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.08042 0.00542 9e-34 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0995489 0.00821556 1.240811e-33 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0991242 0.00821591 2.3281320000000002e-33 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0991131 0.00821592 2.366704e-33 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Richard MA CHARGE 29198723 2019-11-25 Systolic Blood Pressure EFO_0006335 Meta-analysis Table S4 DNA methylation Systolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0002 None 1.6e-32 None 29198723_Richard-MA_systolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.104795 0.00885883 3.852465e-32 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0968689 0.00821774 6.287665e-32 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.095224 0.00810897 1.0632690000000001e-31 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0977554 0.0083248 1.067881e-31 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.096455 0.00821807 1.1418750000000001e-31 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 CD14+ monocytes Table S7 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 CD14+ monocytes - 1251 1 60 Both European,African,Admixed cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.00107 8.84e-05 1.24e-31 - 27843151_alcohol_consumption_per_day_cd14_monocytes Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 1.97801 0.10797 1.31e-31 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.100212 0.00857648 2.107935e-31 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.09769 0.00842934 6.369812e-31 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0961098 0.00832203 1.016153e-30 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0958064 0.00833281 1.834265e-30 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0976729 0.00849846 1.9319749999999998e-30 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0944576 0.00821966 1.960702e-30 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.100931 0.00883342 4.1553189999999996e-30 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based), body mass index Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 7.4e-30 None 31386212_Xu-K_alcohol_consumption_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0934316 0.00822045 8.253548e-30 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0930694 0.00832603 6.828210000000001e-29 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0931223 0.00833372 7.137319e-29 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.23993 0.0216301 1.684998e-28 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Xu K National Health and Resilience in Veterans Study 31386212 2019-08-06 Alcohol Consumption EFO_0004329, EFO_0007878 not adjusted for bmi Table 2 DNA methylation Alcohol Consumption Age, smoking, cell composition (reference based) Beta Values AUDIT-C score Illumina HumanMethylationEPIC Saliva None 1135 1 Adults Males European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 2.7000000000000003e-28 None 31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi Sayols-Baixeras S REGICOR, Framingham Offspring Study 29099282 2017-11-27 Waist circumference EFO_0004342 Meta-analysis model 2 Supplementary table 4 Waist circumference DNA methylation Age, sex, smoking, cell composition (reference based), batch effects cm M Values Illumina HumanMethylation450 Whole blood Removed individuals with BMI < 18.5 3156 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -2.2 0.2 3.8000000000000005e-28 None 29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0915021 0.00832591 5.4871500000000005e-28 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0892305 0.00818652 1.475127e-27 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 1.8 0.162 2e-27 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.09117 0.00843717 4.090163e-27 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0885039 0.00822417 6.597236e-27 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.088288 0.00822433 8.768438e-27 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06206831 chr4:139103485 4 139103485 SLC7A11 Open sea -0.02082 0.00168 1.9999999999999998e-26 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0874435 0.00822494 2.6511139999999996e-26 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0872641 0.00822507 3.349006e-26 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.086951 0.0082253 5.0292469999999997e-26 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Richard MA CHARGE 29198723 2019-11-25 Diastolic Blood Pressure EFO_0006336 Meta-analysis Table S4 DNA methylation Diastolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0003 None 7.9e-26 None 29198723_Richard-MA_diastolic_blood_pressure_meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.268942 0.0258007 2.294923e-25 None 39706196_Hannah-M.-Smith_bmi_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.046 0.00442 2.9e-25 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0853796 0.0082577 5.695924000000001e-25 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0849658 0.00822671 6.406258e-25 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0839025 0.00822746 2.443587e-24 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0837132 0.00822759 3.095857e-24 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.01 0.1 3.7999999999999995e-24 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0832376 0.00822792 5.596127e-24 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0841184 0.00834072 7.676934e-24 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.26002 0.0258655 1.037397e-23 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.205637 0.0205527 1.6594410000000002e-23 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0831583 0.00834476 2.5638940000000003e-23 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0817437 0.00822894 3.5162180000000006e-23 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.081623 0.00822902 4.073058e-23 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0806104 0.00812759 4.1058980000000006e-23 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0870255 0.00878703 4.73264e-23 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0824848 0.00833831 5.308616e-23 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Meta-analysis Table S2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 1450 2 63.5 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.012 0.001 1.2e-22 - 28624579_gammaglutamyl_transferase_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0866668 0.00884028 1.275082e-22 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0827501 0.00845183 1.4460699999999999e-22 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.25143 0.0257907 2.130891e-22 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.348169 0.0357997 2.678524e-22 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0799515 0.00823014 3.0523060000000002e-22 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.96 0.1 3.9000000000000004e-22 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Replication adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 2542 1 66.3 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.044 0.005 5.4e-22 - 28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0805935 0.00835009 5.613393e-22 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0790032 0.00823076 9.395122e-22 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0799971 0.00834239 1.02763e-21 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -2.5 0.264 1.6e-21 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.309354 0.0324889 1.91999e-21 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Sayols-Baixeras S REGICOR, Framingham Offspring Study 29099282 2017-11-27 Waist circumference EFO_0004342 Meta-analysis model 1 Supplementary table 4 Waist circumference DNA methylation Age, sex, smoking, cell composition (reference based) cm M Values Illumina HumanMethylation450 Whole blood Removed individuals with BMI < 18.5 3156 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.9 0.2 2.1e-21 None 29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.341374 0.0359347 2.370177e-21 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0781758 0.0082313 2.478746e-21 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 Discovery and replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood Weighted Z-test meta-analysis 10238 13 54.5 Both European,South Asian cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea - - 2.5e-21 - 28002404_body_mass_index_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0790965 0.00833141 2.565586e-21 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0780124 0.00823141 2.998596e-21 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0778913 0.00823149 3.452126e-21 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0775664 0.0082317 5.031687e-21 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0781422 0.00833339 7.76268e-21 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0780909 0.0083289 7.843523e-21 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.303769 0.0325922 1.296607e-20 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0783068 0.00840956 1.4342879999999998e-20 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Replication Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 2542 1 66.3 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.042 0.005 1.5e-20 - 28173150_serum_triglycerides_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0762816 0.00823251 2.1987699999999998e-20 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.329323 0.0357086 3.2291899999999996e-20 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0766421 0.00834846 4.860006e-20 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0218554 0.0023943 6.98e-20 - 28213390_serum_triglycerides_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0766564 0.00839366 7.543398999999999e-20 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.078998 0.00868416 1.0483029999999999e-19 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.295603 0.0325217 1.10126e-19 None 39706196_Hannah-M.-Smith_bmi_discovery Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0123339 0.0013665 1.78e-19 - 28213390_serum_triglycerides_discovery_and_replication Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.0013 None 2.3e-19 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0737611 0.00823408 3.697252e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry discovery Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 2707 3 57.9 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -19 2.13 4.4e-19 - 28002404_body_mass_index_european_ancestry_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0734747 0.00823425 5.065471e-19 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0774828 0.00868349 5.068755e-19 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0744782 0.00835114 5.284927e-19 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.073264 0.00823438 6.380096999999999e-19 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.073255 0.00823439 6.443214e-19 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0726341 0.00823476 1.267085e-18 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0739883 0.00840717 1.510572e-18 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0767811 0.00878522 2.585452e-18 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0753227 0.00862014 2.627124e-18 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0716557 0.00823535 3.635531e-18 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.5 0.17 5.1e-18 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0765002 0.00889341 8.628476000000001e-18 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0703523 0.00823611 1.44846e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.214092 0.0251152 1.65429e-17 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.071088 0.00834348 1.746555e-17 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0749712 0.00882564 2.173527e-17 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0699428 0.00823635 2.2246830000000002e-17 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0713691 0.0084559 3.4628680000000005e-17 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0694362 0.00823664 3.7702130000000006e-17 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.081 0.0097 6.9e-17 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.074298 0.00889542 7.284864e-17 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0686907 0.00823707 8.13779e-17 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg06623625 chr4:139137902 4 139137902 SLC7A11 Open sea 0.30992 0.0372 8.39e-17 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0679931 0.00825986 1.999328e-16 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 LAtoFA None Meta-analysis Table S2 DNA methylation LAtoFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Ratio of 18:2 linoleic acid to total fatty acids 5414 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.52 0.064 2e-16 None 33413638_Gomez-Alonso-MDC_latofa_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.068381 0.0083533 2.918564e-16 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0676701 0.00832244 4.594804e-16 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0669321 0.00823806 4.838404e-16 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0668047 0.00835549 0.000000000000001388513 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0198334 0.0024874 0.00000000000000154 - 28213390_serum_triglycerides_discovery_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0665052 0.00833612 0.000000000000001597208 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Jiantao Ma FHS 30796027 Feb 22, 2019 hepatic fat EFO_0010821 Discovery Table 1 DNA methylation hepatic fat Age, Sex, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylation450 whole blood None 1496 1 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.0000000000000018 None 30796027_Jiantao-Ma_hepatic_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0655719 0.0082388 0.000000000000001862092 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 FAw6toFA None Meta-analysis Table S2 DNA methylation FAw6toFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Omega-6 fatty acids 5414 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.43 0.054 0.0000000000000027 None 33413638_Gomez-Alonso-MDC_faw6tofa_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.068846 0.00872027 0.000000000000003109754 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0651233 0.00834101 0.000000000000006221379 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0637106 0.0082398 0.00000000000001126729 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.063706 0.0082398 0.00000000000001131706 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0635841 0.00823986 0.00000000000001271096 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0634141 0.00823995 0.00000000000001494036 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Discovery Table 2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 731 1 59.6 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.011 0.001 0.000000000000015 - 28624579_gammaglutamyl_transferase_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0633745 0.00823997 0.0000000000000155119 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0632606 0.00824003 0.00000000000001727961 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Sayols-Baixeras S REGICOR, Framingham Offspring Study 29099282 2017-11-27 Body mass index EFO_0004340 Meta-analysis model 2 Supplementary table 3 Body mass index DNA methylation Age, sex, smoking, cell composition (reference based), batch effects Kg/m2 M Values Illumina HumanMethylation450 Whole blood Removed individuals with BMI < 18.5 3156 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.71 0.09 0.00000000000002 None 29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_2 Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 2 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 2 = model 1 + smoking + physical activity + alcohol consumption 3400 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000000000000023 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0628901 0.00824023 0.00000000000002451869 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0622524 0.00824056 0.00000000000004456266 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0635094 0.00842007 0.00000000000004876136 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0628877 0.00834674 0.00000000000005191892 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.06213 0.00826711 0.00000000000006005219 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 1 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 1 = adjusted for sex + age 3400 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000000000000068 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0107 0.0014 0.0000000000000749 - 28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0616687 0.00824572 0.00000000000007920421 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0616095 0.00824089 0.00000000000008090254 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PRSS2 protein levels (SeqId = 5034-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS2 protein levels (SeqId = 5034-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trypsin-2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.74 0.1 0.0000000000001 None Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement Ligthart S CHARGE 27955697 2016-12-12 C-reactive protein EFO_0004458 Discovery Table S3 DNA methylation C-reactive protein Age, sex, smoking, body mass index, cell counts and technical covariates Beta values mg/l Illumina HumanMethylation450 Whole blood C-reactive protein levels were log-transformed 8863 9 65 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0048 0.000647 0.000000000000121 - 27955697_creactive_protein_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0612472 0.00826021 0.000000000000128545 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0627277 0.00846162 0.0000000000001300213 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0656609 0.00886585 0.0000000000001372168 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0609888 0.0082412 0.0000000000001430606 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0604896 0.00824145 0.0000000000002253406 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.061555 0.00839538 0.0000000000002385684 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0612957 0.00836046 0.0000000000002392822 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0619129 0.00844775 0.0000000000002441271 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0650624 0.00888485 0.0000000000002554008 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0601723 0.00824161 0.0000000000003002425 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0642079 0.00879552 0.0000000000003024154 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.247264 0.0340304 0.0000000000003860741 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0615995 0.00848461 0.0000000000004061284 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0646235 0.00892474 0.0000000000004677839 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0595518 0.00824192 0.0000000000005239363 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Sayols-Baixeras S REGICOR, Framingham Offspring Study 29099282 2017-11-27 Body mass index EFO_0004340 Meta-analysis model 1 Supplementary table 3 Body mass index DNA methylation Age, sex, smoking, cell composition (reference based) Kg/m2 M Values Illumina HumanMethylation450 Whole blood Removed individuals with BMI < 18.5 3156 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.63 0.09 0.00000000000069 None 29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0590529 0.00824216 0.0000000000008165211 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0598587 0.00835955 0.0000000000008419402 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4851 9 54.5 Both European,South Asian cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -11.7 1.6 0.000000000001 - 28002404_body_mass_index_all_ancestry_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0642069 0.00901873 0.000000000001135354 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ALDOB protein levels (SeqId = 18185-118) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOB protein levels (SeqId = 18185-118) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.71 0.1 0.0000000000012 None Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.061073 0.0086127 0.000000000001392073 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.0583848 0.00824249 0.000000000001470694 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0583577 0.0082425 0.000000000001505994 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0583242 0.00824252 0.000000000001550836 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.034 0.00486 0.0000000000017 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.98 0.28 0.0000000000018 4804 31197173_Liu-J_fasting_glucose_base Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0580782 0.00824263 0.000000000001922314 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0580661 0.00824264 0.000000000001942685 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0595149 0.00848356 0.00000000000239469 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0577882 0.00824277 0.000000000002473676 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ACY1 protein levels (SeqId = 3343-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACY1 protein levels (SeqId = 3343-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aminoacylase-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.7 0.1 0.0000000000027 None Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement Mendelson MM - 28095459 2017-01-17 Body mass index EFO_0004340 Meta-analysis Table S1 DNA methylation Body mass index Age, sex, cell counts and technical covariates Beta values kg/m2 Illumina HumanMethylation450 Whole blood Weighted Z-test meta-analysis 3743 4 69.2 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea - - 0.00000000000275 - 28095459_body_mass_index_metaanalysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea -0.0163 0.00219 0.000000000003 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0571692 0.00824307 0.000000000004219424 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0571607 0.00824307 0.00000000000425013 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0609807 0.00880581 0.000000000004539687 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -1.11 0.161 0.0000000000048 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -1.3 0.188 0.000000000005 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0568751 0.00824321 0.000000000005427372 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0614283 0.00891851 0.000000000005899682 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.072 0.0105 0.000000000006 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0608253 0.00883465 0.000000000006020089 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.057804 0.00839888 0.000000000006126379 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0577979 0.00840087 0.000000000006228045 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0565566 0.00824336 0.000000000007118392 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0565116 0.00824338 0.00000000000739558 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0565907 0.00826433 0.000000000007809543 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.036 0.00529 0.0000000000079 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0563972 0.00824343 0.000000000008148833 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0562557 0.0082435 0.000000000009184759 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0573895 0.00842203 0.000000000009847518 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0566704 0.00831901 0.00000000000998854 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0559887 0.00824362 0.00000000001150352 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0597696 0.00881608 0.00000000001251093 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0557157 0.00824375 0.00000000001446492 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Nano J - 28624579 2017-06-15 Alanine aminotransferase EFO_0004735 Meta-analysis Table S2 DNA methylation Alanine aminotransferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 1450 2 63.5 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.012 0.002 0.000000000019 - 28624579_alanine_aminotransferase_metaanalysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.123481 0.0183952 0.00000000001970494 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0553084 0.00824393 0.00000000002031596 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.055702 0.0083351 0.00000000002428434 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0549869 0.00824408 0.00000000002651938 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0555088 0.00835996 0.00000000003250541 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0544382 0.00824433 0.00000000004164682 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0542051 0.00824443 0.00000000005038062 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0541525 0.00824446 0.00000000005258587 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0540685 0.00824449 0.0000000000563066 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0548003 0.00835616 0.00000000005633291 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0539483 0.00824262 0.00000000006145069 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0539468 0.00824455 0.00000000006215781 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0546748 0.0083643 0.00000000006497642 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.053863 0.00824459 0.00000000006652934 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.192887 0.0296044 0.00000000007446808 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0543366 0.00833956 0.00000000007479987 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -1.04 0.16 0.000000000079 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea 0.0535493 0.00824473 0.00000000008572221 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.054175 0.008354 0.00000000009162165 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0550847 0.00850216 0.00000000009533301 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0534136 0.00824479 0.00000000009561141 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 APOC3 protein levels (SeqId = 6461-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOC3 protein levels (SeqId = 6461-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein C-III 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.64 0.099 0.000000000099 None Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0548438 0.00849 0.0000000001081414 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.00055 0.000086 0.00000000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06623625 chr4:139137902 4 139137902 SLC7A11 Open sea -0.00062 0.000097 0.00000000012 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 European ancestry replication Table S3 Body mass index DNA methylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 4195 8 54.6 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -10.11 1.57 0.00000000013 - 28002404_body_mass_index_european_ancestry_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0540579 0.00841587 0.000000000137438 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.053738 0.00837863 0.0000000001463845 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0528657 0.00824503 0.0000000001481815 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.055 0.00764 0.00000000015 None 32795589_Kyung-WK_eosinophilia_discovery Gadd DA Generation Scotland 35945220 31/07/2022 ADSSL1 protein levels (SeqId = 13998-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADSSL1 protein levels (SeqId = 13998-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adenylosuccinate synthetase isozyme 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.637 0.1 0.00000000016 None Gadd-DA_adssl1_protein_levels__seqid___13998-26__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0534658 0.00836177 0.0000000001664158 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0526531 0.00824512 0.0000000001754334 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.189473 0.0297981 0.0000000002087561 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg13028471 chr4:139163535 4 139163535 SLC7A11 Open sea 0.00804 0.0013 0.000000000231 - 23334450_rheumatoid_arthritis Gadd DA Generation Scotland 35945220 31/07/2022 DEFB1 protein levels (SeqId = 6629-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DEFB1 protein levels (SeqId = 6629-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-defensin 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.628 0.099 0.00000000028 None Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RBP5 protein levels (SeqId = 19241-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP5 protein levels (SeqId = 19241-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.63 0.099 0.00000000029 None Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.051979 0.00824541 0.0000000002983653 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Wahl S - 28002404 2017-01-05 Body mass index EFO_0004340 All ancestry discovery Table S3 Body mass index DNA mehtylation Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates kg/m2 Beta values Illumina HumanMethylation450 Whole blood - 5387 4 54.5 Both European,South Asian cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -6.3 0.9 0.0000000003 - 28002404_body_mass_index_all_ancestry_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0519601 0.00824542 0.000000000302816 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0526726 0.00835947 0.0000000003042811 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0523897 0.00831638 0.0000000003069629 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0518867 0.00824545 0.0000000003207027 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0518631 0.00824546 0.0000000003266881 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0526582 0.00837357 0.0000000003293891 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0517305 0.00824552 0.0000000003622979 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0524078 0.00836533 0.0000000003835198 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0515044 0.00824561 0.000000000431929 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.055776 0.0089326 0.0000000004380287 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0514315 0.00824564 0.000000000457073 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.1719049 0.0275806 0.0000000004581 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0520114 0.00836431 0.0000000005163441 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2 Liang X Veterans Aging Cohort Study 32034291 2020-02-07 Alcohol Consumption EFO_0004329, EFO_0007878 Meta analysis with phosphatidylethanol used as measure for AC Table 2 DNA methylation Alcohol Consumption HIV status, smoking, ancestry (other), age, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 1047 1 Adults Males Admixed cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.00000000055 None 32034291_Liang-X_alcohol_consumption_meta_analysis_with_phosphatidylethanol_used_as_measure_for_ac Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0517969 0.00834827 0.0000000005634367 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0509761 0.00824584 0.0000000006495387 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ASGR1 protein levels (SeqId = 5452-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASGR1 protein levels (SeqId = 5452-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Asialoglycoprotein receptor 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.61 0.099 0.00000000066 None Gadd-DA_asgr1_protein_levels__seqid___5452-71__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0508804 0.00824588 0.0000000006990404 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0516161 0.00836856 0.0000000007103932 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0545521 0.00885057 0.0000000007293734 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ENPP7 protein levels (SeqId = 4435-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ENPP7 protein levels (SeqId = 4435-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.61 0.099 0.00000000079 None Gadd-DA_enpp7_protein_levels__seqid___4435-66__somascan_protein_measurement Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting insulin EFO_0004466 Base Supplementary Data 1 DNA methylation fasting insulin Age, sex, smoking, cell composition (reference based), batch effects Beta Values log pmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.74 0.28 0.00000000089 4736 31197173_Liu-J_fasting_insulin_base Gadd DA Generation Scotland 35945220 31/07/2022 RBP4 protein levels (SeqId = 15633-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP4 protein levels (SeqId = 15633-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.61 0.1 0.000000001 None Gadd-DA_rbp4_protein_levels__seqid___15633-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0535868 0.00881327 0.00000000122985 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01309945 chr4:139126892 4 139126892 SLC7A11 Open sea -0.00052 0.000085 0.0000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0487614 0.00806701 0.000000001534699 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.044 0.00722 0.0000000016 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea - - 0.00000000162 - 26857698_primary_sjogrens_syndrome_whole_blood Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0497173 0.00824636 0.000000001689385 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0496881 0.00824637 0.000000001726821 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.049675 0.00824638 0.000000001743757 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0502791 0.00835158 0.000000001782368 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0494291 0.00824648 0.000000002095816 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0494154 0.00824648 0.000000002117442 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0493928 0.00824649 0.000000002153394 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0493892 0.0082465 0.000000002159166 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0503415 0.0084266 0.000000002366959 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0492637 0.00824655 0.000000002370619 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0499608 0.00836676 0.000000002407491 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0506803 0.00849128 0.00000000244948 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_3 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.00010911 1.83e-05 0.00000000265 - 27843151_alcohol_consumption_per_day_european_ancestry Gadd DA Generation Scotland 35945220 31/07/2022 CES1 protein levels (SeqId = 15487-164) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CES1 protein levels (SeqId = 15487-164) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Liver carboxylesterase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.59 0.1 0.0000000027 None Gadd-DA_ces1_protein_levels__seqid___15487-164__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CBLN1 protein levels (SeqId = 9313-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBLN1 protein levels (SeqId = 9313-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cerebellin-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.59 0.099 0.0000000028 None Gadd-DA_cbln1_protein_levels__seqid___9313-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0490142 0.00824665 0.00000000285269 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0500257 0.00846917 0.000000003565245 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.00133477 0.00022661 0.00000000386 - 27843151_alcohol_consumption_per_day_european_ancestry Nano J - 28624579 2017-06-15 Gamma-glutamyl transferase EFO_0004532 Replication Table 2 DNA methylation Gamma-glutamyl transferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 719 1 67.5 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.015 0.002 0.0000000039 - 28624579_gammaglutamyl_transferase_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.048366 0.00824691 0.00000000459519 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0019 None 0.0000000047 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0483302 0.00824692 0.000000004716761 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0497752 0.00849503 0.000000004747075 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0483084 0.00824693 0.00000000479233 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0496595 0.00848142 0.000000004869171 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0514451 0.00880314 0.000000005206381 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_4 Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base plus BMI Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects, body mass index Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.58 0.27 0.0000000055 4804 31197173_Liu-J_fasting_glucose_base_plus_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0480991 0.00824702 0.000000005581779 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0486412 0.00835648 0.000000005979936 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00361146 chr4:139163780 4 139163780 SLC7A11 Open sea -0.02961 0.00486 0.0000000061 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 OXT protein levels (SeqId = 8356-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OXT protein levels (SeqId = 8356-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oxytocin-neurophysin 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.58 0.1 0.0000000062 None Gadd-DA_oxt_protein_levels__seqid___8356-88__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0479258 0.00824708 0.000000006329606 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0478803 0.0082471 0.000000006541698 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AKR1C4 protein levels (SeqId = 18397-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR1C4 protein levels (SeqId = 18397-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldo-keto reductase family 1 member C4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.58 0.1 0.0000000066 None Gadd-DA_akr1c4_protein_levels__seqid___18397-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0484952 0.00836841 0.000000006970916 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0477804 0.00824714 0.000000007031663 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0492543 0.00850212 0.000000007048507 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.047702 0.00824717 0.000000007441379 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0491429 0.0085105 0.000000007880054 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0474368 0.00824728 0.00000000900481 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Ma J CARDSYA, FHS, MESA, RS 30936141 2019-02-21 Nonalcoholic fatty liver disease EFO_0003095, EFO_1001248 discovery and replication Table 1 Nonalcoholic fatty liver disease DNA methylation Age, sex, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole Blood, Monocytes None 4525 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.0000000093 None 30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 3 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 3 = model 2 + BMI 3400 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.0000000093 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_3 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg01309945 chr4:139126892 4 139126892 SLC7A11 Open sea 0.11181 0.0195 0.00000000991 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0472297 0.00824736 0.00000001044388 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg00361146 chr4:139163780 4 139163780 SLC7A11 Open sea 0.02023 0.0035 0.0000000105 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.047195 0.00824737 0.00000001070599 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.02959 0.0052 0.000000011 - 23334450_rheumatoid_arthritis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.1696 0.0296965 0.00000001140989 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0470843 0.00824741 0.00000001158565 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0470613 0.00824742 0.00000001177722 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.105081 0.018444 0.00000001237006 None 39706196_Hannah-M.-Smith_body_fat_discovery Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.00094 0.00017 0.000000013 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0471097 0.00828313 0.00000001314328 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0468737 0.0082475 0.00000001345615 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Nabais MF AUS, KCL, NL, SGPD, PEG, AIBL 33771206 2021-03-26 Neurodegenerative disorders EFO_0000253, EFO_0000249, EFO_0002508 Meta-analysis of ALS, AD, PD Table S3 DNA methylation Neurodegenerative disorders Age, Sex, Smoking, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood Meta-analysis of DNAm sites common to the neurodegenerate disorders Alzheimers disease, amyotrophic lateral sclerosis, and Parkinsons disease 7322 6 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.52 0.09 0.000000014 None 33771206_Nabais-MF_neurodegenerative_disorders_meta-analysis_of_als__ad__pd Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0481565 0.00848542 0.00000001411428 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0467916 0.00824753 0.00000001426323 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SULT2A1 protein levels (SeqId = 9829-91) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SULT2A1 protein levels (SeqId = 9829-91) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bile salt sulfotransferase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.56 0.099 0.000000015 None Gadd-DA_sult2a1_protein_levels__seqid___9829-91__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.0466524 0.00824758 0.00000001573753 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AKR7A3 protein levels (SeqId = 18173-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR7A3 protein levels (SeqId = 18173-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aflatoxin B1 aldehyde reductase member 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.56 0.1 0.000000016 None Gadd-DA_akr7a3_protein_levels__seqid___18173-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea 0.0465695 0.00824761 0.00000001668579 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0479915 0.00850096 0.0000000167832 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0465586 0.00824762 0.00000001681487 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.16139 0.0286 0.0000000171 - 25650246_gestational_age Nano J - 28624579 2017-06-15 Alanine aminotransferase EFO_0004735 Discovery Table 2 DNA methylation Alanine aminotransferase Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 731 1 59.6 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.013 0.0023 0.000000018 - 28624579_alanine_aminotransferase_discovery Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.00096 0.00017 0.000000019 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0467716 0.00833219 0.00000002020254 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0467191 0.00835219 0.00000002263334 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.59239265 0.1062 0.0000000241 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0465224 0.00833682 0.0000000244287 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Nicolas Fragoso-Bargas EPIPREG 36534481 Dec 19, 2022 HOMA-IR EFO:0000001 discovery Supplementary Table 2 DNA methylation HOMA-IR Smoking,Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood analysis in pregnancy (cross ancestry) 456 1 Adults (18-65 years) Females European,South Asian cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.153536729 0.02670616 0.0000000246 None 36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0473173 0.00848219 0.00000002469885 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 FBP1 protein levels (SeqId = 7206-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FBP1 protein levels (SeqId = 7206-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-1,6-bisphosphatase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.55 0.099 0.000000027 None Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ASL protein levels (SeqId = 11241-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASL protein levels (SeqId = 11241-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Argininosuccinate lyase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.55 0.099 0.000000028 None Gadd-DA_asl_protein_levels__seqid___11241-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0458207 0.0082479 0.00000002817334 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Nicolas Fragoso-Bargas EPIPREG 36534481 Dec 19, 2022 HOMA-IR EFO:0000001 discovery (european) Supplementary Table 3 DNA methylation HOMA-IR Age,Smoking,Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood analysis in pregnancy (europeans) 294 1 Adults (18-65 years) Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.195339535 0.03436254 0.0000000288 None 36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european) Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0493832 0.00890907 0.00000003024198 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.101905 0.0183885 0.00000003037648 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Gadd DA Generation Scotland 35945220 31/07/2022 SIGLEC7 protein levels (SeqId = 2742-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIGLEC7 protein levels (SeqId = 2742-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialic acid-binding Ig-like lectin 7 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.55 0.1 0.000000034 None Gadd-DA_siglec7_protein_levels__seqid___2742-68__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.045529 0.00824801 0.00000003447623 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0454775 0.00824803 0.00000003572192 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0454053 0.00824806 0.00000003754232 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0460198 0.0083637 0.00000003810964 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0458898 0.00834038 0.00000003815146 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Braun KVE - 28194238 2016-06-16 Triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S1 DNA methylation Triglycerides Age, sex, smoking, cell counts and technical covariates Beta values mmol/l Illumina HumanMethylation450 Whole blood - 1485 2 64 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0089 0.0016 0.0000000391 - 28194238_triglycerides_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0453267 0.00824809 0.00000003962825 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Song N St Jude Lifetime Cohort 33823916 2021-04-06 Cancer treatment: Asparaginase enzymes and epipodophyllotoxins None None Table S2 DNA methylation Cancer treatment: Asparaginase enzymes and epipodophyllotoxins sex, age, other cancer treatment exposures, cell composition (reference based), ancestry (genomic PCs), batch effects M Values None Illumina HumanMethylationEPIC Whole blood None 2052 1 Children Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.099 0.02 0.000000043 None 33823916_Song-N_cancer_treatment__asparaginase_enzymes_and_epipodophyllotoxins Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.04893 0.00892992 0.00000004339781 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0451694 0.00824814 0.00000004414179 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CELA2A protein levels (SeqId = 7140-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CELA2A protein levels (SeqId = 7140-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chymotrypsin-like elastase family member 2A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.54 0.1 0.000000047 None Gadd-DA_cela2a_protein_levels__seqid___7140-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0514247 0.00940954 0.00000004700493 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.234075 0.0428497 0.0000000475454 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06206831 chr4:139103485 4 139103485 SLC7A11 Open sea 0.00064 None 0.000000051 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0455687 0.00836219 0.00000005136099 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Fully-adjusted Model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 14315 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.042 0.00767 0.000000057 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Fully-adjusted_Model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.04469 0.00824832 0.00000006119659 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Vallerga CL SGPD, Parkinson's disease Environment and Gene 32144264 2020-03-06 Parkinson's disease EFO_0002508 Meta analysis using MOA model from OSCA Supplementary dataset 3 Parkinson's disease DNA methylation Sex, age, batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 2131 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 1.09 0.2 0.000000062 None 32144264_Vallerga-CL_parkinson_s_disease_meta_analysis_using_moa_model_from_osca Gadd DA Generation Scotland 35945220 31/07/2022 BOC protein levels (SeqId = 4328-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BOC protein levels (SeqId = 4328-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Brother of CDO 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.54 0.1 0.000000062 None Gadd-DA_boc_protein_levels__seqid___4328-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0457627 0.0084588 0.00000006398976 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_3 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13028471 chr4:139163535 4 139163535 SLC7A11 Open sea 0.01084 0.00193 0.000000067 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0507734 0.00941057 0.000000069449 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.192074 0.0356626 0.00000007300253 None 39706196_Hannah-M.-Smith_glucose_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 OMD protein levels (SeqId = 5358-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OMD protein levels (SeqId = 5358-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Osteomodulin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.53 0.099 0.00000008 None Gadd-DA_omd_protein_levels__seqid___5358-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FAH protein levels (SeqId = 11424-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAH protein levels (SeqId = 11424-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fumarylacetoacetase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.53 0.099 0.000000081 None Gadd-DA_fah_protein_levels__seqid___11424-4__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0441997 0.0082485 0.00000008518058 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.043984 0.00824858 0.00000009840547 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.15454 0.0289968 0.00000009962655 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 PTPRJ protein levels (SeqId = 8250-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTPRJ protein levels (SeqId = 8250-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor-type tyrosine-protein phosphatase eta 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.53 0.1 0.0000001 None Gadd-DA_ptprj_protein_levels__seqid___8250-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CCL16 protein levels (SeqId = 4913-78) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CCL16 protein levels (SeqId = 4913-78) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-C motif chemokine 16 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.53 0.099 0.0000001 None Gadd-DA_ccl16_protein_levels__seqid___4913-78__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0439142 0.00824861 0.0000001031024 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0442214 0.00832379 0.0000001096174 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 IGF2R protein levels (SeqId = 16057-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGF2R protein levels (SeqId = 16057-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cation-independent mannose-6-phosphate receptor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.53 0.1 0.00000011 None Gadd-DA_igf2r_protein_levels__seqid___16057-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0434431 0.00818515 0.000000112725 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.043747 0.00824867 0.0000001152381 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ART4 protein levels (SeqId = 6576-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ART4 protein levels (SeqId = 6576-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ecto-ADP-ribosyltransferase 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.53 0.1 0.00000012 None Gadd-DA_art4_protein_levels__seqid___6576-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0471163 0.00889882 0.0000001209538 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0436688 0.0082487 0.0000001213765 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0436294 0.00824871 0.0000001245886 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mendelson MM - 28095459 2017-01-17 Body mass index EFO_0004340 Framingham Heart Study Batch 2 Table S1 DNA methylation Body mass index Age, sex and technical covariates - kg/m2 Illumina HumanMethylation450 Whole blood DNA methylation was inverse normally rank transformed 1935 1 67 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0217 0.00408 0.000000127 - 28095459_body_mass_index_framingham_heart_study_batch_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0435918 0.00824872 0.0000001277349 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.04848 0.00918193 0.0000001310809 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0433952 0.00824879 0.0000001454481 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0433527 0.00824881 0.0000001495839 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0433333 0.00824882 0.000000151512 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Ligthart S CHARGE 27955697 2016-12-12 C-reactive protein EFO_0004458 Replication Table S3 DNA methylation C-reactive protein Age, sex, smoking, body mass index, cell counts and technical covariates Beta values mg/l Illumina HumanMethylation450 Whole blood C-reactive protein levels were log-transformed 4111 4 59.7 Missing African cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0029 0.000552 0.000000152 - 27955697_creactive_protein_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0432313 0.00824885 0.0000001620251 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.0433736 0.00827609 0.0000001620679 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0446341 0.00851929 0.0000001635228 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0432123 0.00824886 0.0000001640514 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.02 0.00377 0.00000019 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18059 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.054 0.0104 0.00000019 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model Ding, Yuan Chun California Teachers Study 34425644 Jul 19, 2021 Polybrominated diphenyl ethers (PBDEs) EFO_0007962 Discovery Table 3 DNA methylation Polybrominated diphenyl ethers (PBDEs) Age, Smoking, Cell composition (reference based), Ancestry (other), Body mass index, Menopausal status, age at parity, alcohol, hormone replacement therapy, sample collection center, sample collection year, M values ng/g Illumina HumanMethylationEPIC Whole blood None 313 1 Adults Females European, East Asian, South Asian, African, Admixed, Other cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.007 None 0.00000019 None 34425644_Ding,-Yuan-Chun_polybrominated_diphenyl_ethers__pbdes__discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0429317 0.00824896 0.0000001971433 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.042916 0.00824896 0.0000001991799 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0428393 0.00824899 0.0000002093852 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HRSP12 protein levels (SeqId = 14636-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HRSP12 protein levels (SeqId = 14636-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 2-iminobutanoate/2-iminopropanoate deaminase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.52 0.1 0.00000021 None Gadd-DA_hrsp12_protein_levels__seqid___14636-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADH4 protein levels (SeqId = 8325-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH4 protein levels (SeqId = 8325-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.52 0.099 0.00000022 None Gadd-DA_adh4_protein_levels__seqid___8325-37__somascan_protein_measurement Battram T ARIES None 2020-08-20 VLDL cholesterol EFO_0008317 fasting None DNA methylation VLDL cholesterol Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.94 0.179 0.00000022 None Battram-T_vldl_cholesterol_fasting Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0427353 0.00824903 0.0000002240483 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0459202 0.00886702 0.00000022632 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0427157 0.00824904 0.0000002269126 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Battram T ARIES None 2020-08-20 Triglycerides EFO_0004530 fasting None DNA methylation Triglycerides Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.082 0.00000023 None Battram-T_triglycerides_fasting Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0484507 0.00938049 0.0000002435314 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.0425008 0.00824911 0.0000002608333 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.019 0.0037 0.00000028 None Robert-F-Hillary_Incident_COPD_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 DCXR protein levels (SeqId = 17758-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DCXR protein levels (SeqId = 17758-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: L-xylulose reductase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.51 0.1 0.00000028 None Gadd-DA_dcxr_protein_levels__seqid___17758-79__somascan_protein_measurement Yang BZ - 23332324 2013-02-01 Child abuse - - Appendix B DNA methylation Child abuse Sex, age and ethnicity Beta values - Illumina HumanMethylation450 Saliva - 192 1 10 Both European,African,Admixed,Other cg15441006 chr4:139110589 4 139110589 SLC7A11 Open sea - - 0.000000282 - 23332324_child_abuse Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0452308 0.00882466 0.0000003005182 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.174856 0.0341344 0.0000003046237 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0422042 0.00824921 0.0000003157711 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HMGCS2 protein levels (SeqId = 13704-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMGCS2 protein levels (SeqId = 13704-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hydroxymethylglutaryl-CoA synthase, mitochondrial 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.51 0.1 0.00000035 None Gadd-DA_hmgcs2_protein_levels__seqid___13704-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0464777 0.00912231 0.0000003531701 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0430101 0.00845543 0.0000003688811 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0410139 0.00806425 0.0000003704149 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0419362 0.00824931 0.0000003748945 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0422975 0.00832404 0.0000003793382 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.172799 0.0340304 0.0000003858258 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.100511 0.0197959 0.0000003866467 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0417912 0.00824936 0.0000004112047 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0417893 0.00824936 0.0000004117192 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.028 0.00561 0.00000045 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0690986 0.0136941 0.0000004568363 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0446477 0.00885155 0.0000004612303 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_4 Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 645 1 63.2 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.04 0.008 0.00000049 - 28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0415144 0.00824945 0.0000004901557 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0414716 0.00824947 0.0000005036135 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea -0.00075 0.00015 0.00000052 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 GSTA1 protein levels (SeqId = 17138-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GSTA1 protein levels (SeqId = 17138-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutathione S-transferase A1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.5 0.1 0.00000054 None Gadd-DA_gsta1_protein_levels__seqid___17138-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0412636 0.00824954 0.0000005741678 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0412562 0.00824954 0.0000005768305 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0674758 0.013501 0.0000005864878 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 GBP1 protein levels (SeqId = 15326-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GBP1 protein levels (SeqId = 15326-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanylate-binding protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.098 0.0000006 None Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 HERC5 protein levels (SeqId = 12934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HERC5 protein levels (SeqId = 12934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ISG15--protein ligase HERC5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.496 0.1 0.00000062 None Gadd-DA_herc5_protein_levels__seqid___12934-1__somascan_protein_measurement Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06623625 chr4:139137902 4 139137902 SLC7A11 Open sea 0.01195 0.00232 0.00000063 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gadd DA Generation Scotland 35945220 31/07/2022 OTC protein levels (SeqId = 15431-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OTC protein levels (SeqId = 15431-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ornithine carbamoyltransferase, mitochondrial 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.5 0.1 0.00000064 None Gadd-DA_otc_protein_levels__seqid___15431-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0410699 0.00824961 0.0000006483522 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0679567 0.0136504 0.0000006485477 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 CHAD protein levels (SeqId = 13460-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHAD protein levels (SeqId = 13460-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chondroadherin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.5 0.1 0.00000065 None Gadd-DA_chad_protein_levels__seqid___13460-4__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.0037 None 0.00000065 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.04213 0.00847031 0.0000006637928 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0410253 0.00824962 0.0000006667084 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0409971 0.00824963 0.0000006785722 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CNDP1 protein levels (SeqId = 5456-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CNDP1 protein levels (SeqId = 5456-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-Ala-His dipeptidase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.099 0.0000007 None Gadd-DA_cndp1_protein_levels__seqid___5456-59__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0408728 0.00824967 0.0000007333579 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0408723 0.00824967 0.0000007335842 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0451339 0.00911101 0.000000735998 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0408646 0.00824967 0.0000007371041 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SELE protein levels (SeqId = 3470-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SELE protein levels (SeqId = 3470-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E-selectin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.099 0.00000075 None Gadd-DA_sele_protein_levels__seqid___3470-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0455732 0.00920692 0.000000750833 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.0408166 0.00824969 0.0000007594423 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 AKR1D1 protein levels (SeqId = 18398-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR1D1 protein levels (SeqId = 18398-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-oxo-5-beta-steroid 4-dehydrogenase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.099 0.00000076 None Gadd-DA_akr1d1_protein_levels__seqid___18398-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LGALS9 protein levels (SeqId = 9197-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LGALS9 protein levels (SeqId = 9197-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galectin-9 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.1 0.00000077 None Gadd-DA_lgals9_protein_levels__seqid___9197-4__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Osteoarthritis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Osteoarthritis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 16114 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.037 0.00753 0.00000078 None Robert-F-Hillary_Incident_Osteoarthritis_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0407171 0.00824972 0.0000008079274 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 QRFP protein levels (SeqId = 6463-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QRFP protein levels (SeqId = 6463-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Orexigenic neuropeptide QRFP 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.1 0.00000082 None Gadd-DA_qrfp_protein_levels__seqid___6463-59__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EFS protein levels (SeqId = 12572-236) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EFS protein levels (SeqId = 12572-236) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Embryonal Fyn-associated substrate 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.1 0.00000085 None Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH2 protein levels (SeqId = 18381-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH2 protein levels (SeqId = 18381-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldehyde dehydrogenase, mitochondrial 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.1 0.00000086 None Gadd-DA_aldh2_protein_levels__seqid___18381-16__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.0880197 0.0178801 0.0000008607397 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0405494 0.00824978 0.000000896475 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0409964 0.00834922 0.0000009195942 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.0404405 0.00824982 0.0000009588666 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea 0.0403952 0.00824983 0.0000009860379 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ALDH1A1 protein levels (SeqId = 11265-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH1A1 protein levels (SeqId = 11265-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinal dehydrogenase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.49 0.1 0.00000099 None Gadd-DA_aldh1a1_protein_levels__seqid___11265-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea 0.0403465 0.00824985 0.00000101608 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0414855 0.0085018 0.000001074116 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0415277 0.00851396 0.000001085114 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0402387 0.00824988 0.000001085755 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 1.5 0.299 0.0000011 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0400889 0.00824993 0.000001190215 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0413063 0.00850186 0.000001194999 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0399451 0.00822918 0.000001221944 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0417419 0.00860764 0.000001251038 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.072 0.0148 0.0000013 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02559773 chr4:139157773 4 139157773 SLC7A11 Open sea 0.0398593 0.00825001 0.000001369263 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 C5orf38 protein levels (SeqId = 6378-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C5orf38 protein levels (SeqId = 6378-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein CEI 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.48 0.099 0.0000014 None Gadd-DA_c5orf38_protein_levels__seqid___6378-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRSS8 protein levels (SeqId = 15513-108) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS8 protein levels (SeqId = 15513-108) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prostasin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.48 0.099 0.0000014 None Gadd-DA_prss8_protein_levels__seqid___15513-108__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IGFBP4 protein levels (SeqId = 2950-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGFBP4 protein levels (SeqId = 2950-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like growth factor-binding protein 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.48 0.1 0.0000015 None Gadd-DA_igfbp4_protein_levels__seqid___2950-57__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0396719 0.00825007 0.00000153439 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0409431 0.00851632 0.000001542643 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.0394303 0.00825015 0.000001775743 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CHST9 protein levels (SeqId = 11646-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHST9 protein levels (SeqId = 11646-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carbohydrate sulfotransferase 9 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.476 0.1 0.0000018 None Gadd-DA_chst9_protein_levels__seqid___11646-4__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.027 0.00564 0.0000018 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0393207 0.00825019 0.000001896813 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CFHR1 protein levels (SeqId = 15468-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFHR1 protein levels (SeqId = 15468-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement factor H-related protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.098 0.0000019 None Gadd-DA_cfhr1_protein_levels__seqid___15468-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0392851 0.0082502 0.000001937889 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SLAMF6 protein levels (SeqId = 5128-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLAMF6 protein levels (SeqId = 5128-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: SLAM family member 6 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.000002 None Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg15867963 chr4:139143309 4 139143309 SLC7A11 Open sea -0.0391537 0.00825024 0.000002096772 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Sharp G PACE 33517419 2021-01-29 Maternal body mass index EFO_0004340 Unadjusted for paternal BMI using cord blood https://osf.io/ebtw7/ DNA methylation Maternal body mass index cell composition (reference based), batch effects, maternal age, paternal age, maternal smoking during pregnancy, paternal smoking during or prior to pregnancy, socio-economic position and maternal parity Beta Values kg/m2 Illumina HumanMethylation450, Illumina HumanMethylationEPIC Cord blood Probes that were common to both arrays were included in the meta-analysis 4894 13 Infants Both European, Admixed, South Asian cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.00375 0.00079 0.0000021 None 33517419_Sharp-G_maternal_body_mass_index_unadjusted_for_paternal_bmi_using_cord_blood Gadd DA Generation Scotland 35945220 31/07/2022 HMGCS1 protein levels (SeqId = 13496-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMGCS1 protein levels (SeqId = 13496-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.0000021 None Gadd-DA_hmgcs1_protein_levels__seqid___13496-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LRRTM4 protein levels (SeqId = 8646-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRRTM4 protein levels (SeqId = 8646-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat transmembrane neuronal protein 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.0000021 None Gadd-DA_lrrtm4_protein_levels__seqid___8646-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADIPOQ protein levels (SeqId = 3554-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADIPOQ protein levels (SeqId = 3554-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Adiponectin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.47 0.1 0.0000021 None Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL11A2 protein levels (SeqId = 11278-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL11A2 protein levels (SeqId = 11278-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-2(XI) chain 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.47 0.1 0.0000022 None Gadd-DA_col11a2_protein_levels__seqid___11278-4__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Pain (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Pain (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 18413 1 Adults (18-65y) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.13 0.0269 0.0000022 None Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0472964 0.00999085 0.000002222284 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Vallerga CL SGPD, Parkinson's disease Environment and Gene 32144264 2020-03-06 Parkinson's disease EFO_0002508 Meta analysis using MOMENT model from OSCA Supplementary dataset 3 Parkinson's disease DNA methylation Sex, age, batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 2131 2 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.92 0.2 0.0000023 None 32144264_Vallerga-CL_parkinson_s_disease_meta_analysis_using_moment_model_from_osca Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.056 0.0118 0.0000023 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 PRG2 protein levels (SeqId = 7258-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG2 protein levels (SeqId = 7258-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone marrow proteoglycan 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.76 0.161 0.0000023 None Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea 0.0389623 0.0082503 0.000002350887 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0389488 0.00825031 0.000002369847 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 FTL protein levels (SeqId = 15324-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTL protein levels (SeqId = 15324-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin light chain 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.0000024 None Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LYPD1 protein levels (SeqId = 9327-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LYPD1 protein levels (SeqId = 9327-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ly6/PLAUR domain-containing protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.469 0.1 0.0000024 None Gadd-DA_lypd1_protein_levels__seqid___9327-3__somascan_protein_measurement Colicino E CHARGE 32697766 07-22-2020 All cause mortality EFO_0004352 basic model Table S2 All cause mortality DNA methylation Age, Sex, Cell composition (reference based), Batch effects None M values Illumina HumanMethylation450 Whole blood Effect estimates represent hazard ratio per 10% increase in DNA methylation. 12300 12 Adults Both European, African cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.93 None 0.0000025 None 32697766_Colicino-E_all_cause_mortality_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0388557 0.00825034 0.000002504837 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0391723 0.00832057 0.000002525795 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0410249 0.00872071 0.000002570626 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_4 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.011 0.002 0.00000258 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Gadd DA Generation Scotland 35945220 31/07/2022 PTPN2 protein levels (SeqId = 3401-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTPN2 protein levels (SeqId = 3401-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tyrosine-protein phosphatase non-receptor type 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.0000026 None Gadd-DA_ptpn2_protein_levels__seqid___3401-8__somascan_protein_measurement Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0108 0.0023 0.0000026 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0394091 0.00838347 0.000002614986 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea 0.03871 0.00825038 0.000002731148 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.03867 0.0082504 0.000002796717 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0391268 0.00835397 0.000002843796 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Battram T ARIES None 2020-08-20 Free cholesterol to total lipids ratio in large HDL EFO_0008591 None None DNA methylation Free cholesterol to total lipids ratio in large HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.159 0.034 0.0000029 None Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_hdl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.0385961 0.00825042 0.000002921619 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0389787 0.00833703 0.000002960271 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0411147 0.00879821 0.000002993669 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 TK1 protein levels (SeqId = 4301-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TK1 protein levels (SeqId = 4301-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thymidine kinase, cytosolic 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.000003 None Gadd-DA_tk1_protein_levels__seqid___4301-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FTH1 protein levels (SeqId = 5934-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FTH1 protein levels (SeqId = 5934-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ferritin heavy chain|Ferritin light chain 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.47 0.1 0.000003 None Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement Battram T ARIES None 2020-08-20 Ratio of polyunsaturated fatty acids to total fatty acids EFO_0010733, EFO_0005110 None None DNA methylation Ratio of polyunsaturated fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.059 0.0126 0.000003 None Battram-T_ratio_of_polyunsaturated_fatty_acids_to_total_fatty_acids Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0396365 0.00849423 0.000003094001 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 MASP1 protein levels (SeqId = 9125-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MASP1 protein levels (SeqId = 9125-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mannan-binding lectin serine protease 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.46 0.1 0.0000031 None Gadd-DA_masp1_protein_levels__seqid___9125-23__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL12B protein levels (SeqId = 10365-132) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL12B protein levels (SeqId = 10365-132) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-12 subunit beta|Interleukin-23 subunit alpha 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.464 0.099 0.0000031 None Gadd-DA_il12b_protein_levels__seqid___10365-132__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.149535 0.0321014 0.000003212848 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0384342 0.00825047 0.000003214431 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0436674 0.00937931 0.00000325692 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0383803 0.00825049 0.000003317882 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.015 0.0032 0.0000034 None Robert-F-Hillary_Incident_COPD_Basic_model Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 1955 3 61 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0077073 0.0016656 0.0000037 - 28213390_serum_triglycerides_replication Gadd DA Generation Scotland 35945220 31/07/2022 KRT1 protein levels (SeqId = 9931-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT1 protein levels (SeqId = 9931-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type II cytoskeletal 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.46 0.1 0.0000037 None Gadd-DA_krt1_protein_levels__seqid___9931-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0374578 0.00810327 0.000003822849 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0380915 0.00825058 0.000003929523 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SPINK14 protein levels (SeqId = 8587-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPINK14 protein levels (SeqId = 8587-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine protease inhibitor Kazal-type 14 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.46 0.1 0.000004 None Gadd-DA_spink14_protein_levels__seqid___8587-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NGRN protein levels (SeqId = 7153-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NGRN protein levels (SeqId = 7153-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neugrin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.46 0.099 0.0000042 None Gadd-DA_ngrn_protein_levels__seqid___7153-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0408112 0.00887379 0.000004279219 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0384014 0.00835965 0.000004391719 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18059 1 Adults (18-65y) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.058 0.0127 0.0000044 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0378761 0.00825065 0.000004454782 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0378473 0.00825066 0.000004529819 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0378404 0.00825066 0.000004547946 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0378024 0.00825067 0.00000464942 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0377871 0.00825067 0.000004690672 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.0377456 0.00825069 0.000004804785 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0382679 0.00836888 0.000004855398 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 MAD2L1 protein levels (SeqId = 15313-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAD2L1 protein levels (SeqId = 15313-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitotic spindle assembly checkpoint protein MAD2A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.1 0.000005 None Gadd-DA_mad2l1_protein_levels__seqid___15313-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SOD3 protein levels (SeqId = 5660-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SOD3 protein levels (SeqId = 5660-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Extracellular superoxide dismutase [Cu-Zn] 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.45 0.099 0.000005 None Gadd-DA_sod3_protein_levels__seqid___5660-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0387738 0.00851346 0.000005295667 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Jiantao Ma RS, MESA, CARDIA 30796027 Feb 22, 2019 hepatic fat EFO_0010821 Replication Table 1 DNA methylation hepatic fat Age, Sex, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylation450 whole blood None 1904 3 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.0000053 None 30796027_Jiantao-Ma_hepatic_fat_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13028471 chr4:139163535 4 139163535 SLC7A11 Open sea -0.0375661 0.00825074 0.000005329728 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0385867 0.00849814 0.000005654007 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Mendelson MM - 28095459 2017-01-17 Body mass index EFO_0004340 Lothian Birth Cohort 1936 Table S1 DNA methylation Body mass index Age, sex and cell counts Beta values kg/m2 Illumina HumanMethylation450 Whole blood - 920 1 70 Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0181 0.00396 0.00000574 - 28095459_body_mass_index_lothian_birth_cohort_1936 Gadd DA Generation Scotland 35945220 31/07/2022 CLN5 protein levels (SeqId = 8874-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLN5 protein levels (SeqId = 8874-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ceroid-lipofuscinosis neuronal protein 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.1 0.0000058 None Gadd-DA_cln5_protein_levels__seqid___8874-53__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NFASC protein levels (SeqId = 7179-69) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NFASC protein levels (SeqId = 7179-69) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neurofascin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.1 0.0000058 None Gadd-DA_nfasc_protein_levels__seqid___7179-69__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0408895 0.0090163 0.000005804225 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0386218 0.00851763 0.000005824234 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0379461 0.00836931 0.000005834627 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0373912 0.0082508 0.000005893863 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ZNF275 protein levels (SeqId = 9609-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF275 protein levels (SeqId = 9609-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 275 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.1 0.0000059 None Gadd-DA_znf275_protein_levels__seqid___9609-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.73 0.161 0.000006 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0373427 0.00825081 0.000006060064 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0373278 0.00825082 0.000006112044 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0373163 0.00825082 0.000006152183 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0372992 0.00825083 0.000006212791 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.0360259 0.00796935 0.000006215901 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.037287 0.00825083 0.000006256496 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GIP protein levels (SeqId = 5755-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GIP protein levels (SeqId = 5755-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gastric inhibitory polypeptide 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.099 0.0000066 None Gadd-DA_gip_protein_levels__seqid___5755-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0419521 0.00931509 0.000006730629 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.037141 0.00825087 0.000006800688 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADH1C protein levels (SeqId = 15525-294) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH1C protein levels (SeqId = 15525-294) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 1C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.099 0.0000069 None Gadd-DA_adh1c_protein_levels__seqid___15525-294__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.013 0.0028 0.0000069 None 33450751_Mulder-RH_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 CYB5A protein levels (SeqId = 11287-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CYB5A protein levels (SeqId = 11287-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytochrome b5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.447 0.1 0.0000071 None Gadd-DA_cyb5a_protein_levels__seqid___11287-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0370602 0.0082509 0.000007121081 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Lin H - 28067321 2017-01-09 Atrial fibrillation EFO_0000275 - Table S2 DNA methylation Atrial fibrillation Age, sex and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 2639 1 66 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.018 0.004 0.0000072 - 28067321_atrial_fibrillation Gadd DA Generation Scotland 35945220 31/07/2022 CPM protein levels (SeqId = 9416-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPM protein levels (SeqId = 9416-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase M 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.099 0.0000073 None Gadd-DA_cpm_protein_levels__seqid___9416-77__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNMD protein levels (SeqId = 6578-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNMD protein levels (SeqId = 6578-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tenomodulin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.45 0.1 0.0000074 None Gadd-DA_tnmd_protein_levels__seqid___6578-29__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0369886 0.00825092 0.000007416954 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0375402 0.00837535 0.000007442695 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0611922 0.0136608 0.000007542256 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.036931 0.00825094 0.000007663789 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.122773 0.0274476 0.000007762328 None 39706196_Hannah-M.-Smith_bmi_discovery Battram T ARIES None 2020-08-20 Waist circumference EFO_0004342 None None DNA methylation Waist circumference Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values cm Illumina HumanMethylation450 Whole blood None 717 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0123 0.0027 0.0000079 None Battram-T_waist_circumference Gadd DA Generation Scotland 35945220 31/07/2022 ALDOC protein levels (SeqId = 9876-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOC protein levels (SeqId = 9876-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.444 0.1 0.0000083 None Gadd-DA_aldoc_protein_levels__seqid___9876-20__somascan_protein_measurement Sharp G PACE 33517419 2021-01-29 Maternal body mass index EFO_0004340 Adjusted for paternal BMI using cord blood https://osf.io/ebtw7/ DNA methylation Maternal body mass index paternal bmi, cell composition (reference based), batch effects, maternal age, paternal age, maternal smoking during pregnancy, paternal smoking during or prior to pregnancy, socio-economic position and maternal parity Beta Values kg/m2 Illumina HumanMethylation450, Illumina HumanMethylationEPIC Cord blood Probes that were common to both arrays were included in the meta-analysis 4894 13 Infants Both European, Admixed, South Asian cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.00361 0.00081 0.0000084 None 33517419_Sharp-G_maternal_body_mass_index_adjusted_for_paternal_bmi_using_cord_blood Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0367381 0.008251 0.000008547675 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0367181 0.008251 0.000008644856 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 F9 protein levels (SeqId = 5307-12) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 F9 protein levels (SeqId = 5307-12) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coagulation factor IX 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.099 0.0000087 None Gadd-DA_f9_protein_levels__seqid___5307-12__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PTCHD3 protein levels (SeqId = 13517-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTCHD3 protein levels (SeqId = 13517-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Patched domain-containing protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.0000088 None Gadd-DA_ptchd3_protein_levels__seqid___13517-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.0366743 0.00825102 0.00000886078 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0366674 0.00825102 0.000008895468 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 VAT1 protein levels (SeqId = 18175-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 VAT1 protein levels (SeqId = 18175-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synaptic vesicle membrane protein VAT-1 homolog 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.442 0.1 0.0000089 None Gadd-DA_vat1_protein_levels__seqid___18175-65__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0366574 0.00825102 0.000008945865 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.191521 0.0431402 0.00000907276 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0611162 0.0137722 0.000009161606 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 LRRC15 protein levels (SeqId = 6557-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LRRC15 protein levels (SeqId = 6557-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat-containing protein 15 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.44 0.1 0.0000092 None Gadd-DA_lrrc15_protein_levels__seqid___6557-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.03748 0.0084495 0.000009241224 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.037602 0.00848369 0.000009392614 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 KLRK1 protein levels (SeqId = 14095-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLRK1 protein levels (SeqId = 14095-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NKG2-D type II integral membrane protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.0000094 None Gadd-DA_klrk1_protein_levels__seqid___14095-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0370391 0.00835729 0.000009406039 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0365547 0.00825105 0.000009477998 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0377171 0.00851806 0.00000958432 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.042901 0.00970754 0.000009971004 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 MGAT4B protein levels (SeqId = 7141-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MGAT4B protein levels (SeqId = 7141-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.439 0.1 0.00001 None Gadd-DA_mgat4b_protein_levels__seqid___7141-21__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRYZL1 protein levels (SeqId = 9207-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRYZL1 protein levels (SeqId = 9207-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Quinone oxidoreductase-like protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.00001 None Gadd-DA_cryzl1_protein_levels__seqid___9207-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CXCL10 protein levels (SeqId = 4141-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CXCL10 protein levels (SeqId = 4141-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: C-X-C motif chemokine 10 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.00001 None Gadd-DA_cxcl10_protein_levels__seqid___4141-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GCH1 protein levels (SeqId = 11185-145) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GCH1 protein levels (SeqId = 11185-145) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: GTP cyclohydrolase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.00001 None Gadd-DA_gch1_protein_levels__seqid___11185-145__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0364169 0.00825109 0.00001024011 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0364067 0.0082511 0.00001029849 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0362123 0.00820744 0.00001030874 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0363992 0.0082511 0.00001034198 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0363787 0.00825111 0.00001046125 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0363296 0.00825112 0.00001075251 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0362994 0.00825113 0.00001093562 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 BMP1 protein levels (SeqId = 3348-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMP1 protein levels (SeqId = 3348-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.000011 None Gadd-DA_bmp1_protein_levels__seqid___3348-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COX4I2 protein levels (SeqId = 7850-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COX4I2 protein levels (SeqId = 7850-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.000011 None Gadd-DA_cox4i2_protein_levels__seqid___7850-1__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.05 0.0113 0.000011 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 GLYAT protein levels (SeqId = 19506-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GLYAT protein levels (SeqId = 19506-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycine N-acyltransferase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.44 0.1 0.000011 None Gadd-DA_glyat_protein_levels__seqid___19506-6__somascan_protein_measurement Cardenas A Project Viva 31300640 Jul 12, 2019 fractional exhaled nitric oxide (FeNO) EFO_0005536 None Supplementary Data 2 DNA methylation fractional exhaled nitric oxide (FeNO) Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection Beta values ppb Illumina HumanMethylationEPIC nasal epithelium None 517 1 Children Both Other cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -2.59 0.582 0.000011 SE manually calculated 31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_ Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea -0.0362505 0.00825114 0.00001123762 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.011 0.002 0.0000113 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea -0.0364237 0.00830667 0.00001168609 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0361692 0.00825117 0.00001175882 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0360794 0.0082512 0.00001236067 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.152658 0.0349493 0.0000126089 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0365283 0.00836286 0.00001262987 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0370282 0.00848895 0.00001297973 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Battram T ARIES None 2020-08-20 Ratio of omega 6 fatty acids to total fatty acids EFO_0005110 None None DNA methylation Ratio of omega 6 fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 671 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.059 0.0135 0.000013 None Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids Gadd DA Generation Scotland 35945220 31/07/2022 IFNLR1 protein levels (SeqId = 7192-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFNLR1 protein levels (SeqId = 7192-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon lambda receptor 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000013 None Gadd-DA_ifnlr1_protein_levels__seqid___7192-37__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.0407829 0.00935306 0.00001307206 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0588501 0.0135353 0.00001383661 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0367205 0.0084464 0.00001386446 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 NXPH3 protein levels (SeqId = 6054-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NXPH3 protein levels (SeqId = 6054-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neurexophilin-3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000014 None Gadd-DA_nxph3_protein_levels__seqid___6054-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UGT1A6 protein levels (SeqId = 7891-45) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UGT1A6 protein levels (SeqId = 7891-45) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UDP-glucuronosyltransferase 1-6 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000014 None Gadd-DA_ugt1a6_protein_levels__seqid___7891-45__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.048 0.01106 0.000014 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0357378 0.0082513 0.00001493009 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.001 0.00022 0.000015 None 33564054_Kashima-K_gestational_age Gadd DA Generation Scotland 35945220 31/07/2022 SORD protein levels (SeqId = 15447-45) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SORD protein levels (SeqId = 15447-45) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sorbitol dehydrogenase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000015 None Gadd-DA_sord_protein_levels__seqid___15447-45__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCN3 protein levels (SeqId = 5462-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCN3 protein levels (SeqId = 5462-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ficolin-3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000015 None Gadd-DA_fcn3_protein_levels__seqid___5462-62__somascan_protein_measurement Huang D BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY 32520614 2020-11-12 Systolic Blood Pressure EFO_0006335 Discovery Table 2, table 3 DNA methylation Systolic Blood Pressure age, sex, ancestry, body mass index, cell composition (reference based) Beta Values mmHg Illumina HumanMethylation450 Whole blood Includes some twins 4820 15 Adults Both European, Admixed cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000015 None 32520614_Huang-D_systolic_blood_pressure_discovery Gadd DA Generation Scotland 35945220 31/07/2022 CD72 protein levels (SeqId = 7009-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD72 protein levels (SeqId = 7009-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: B-cell differentiation antigen CD72 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.099 0.000015 None Gadd-DA_cd72_protein_levels__seqid___7009-8__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0357263 0.0082513 0.00001502522 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SAT2 protein levels (SeqId = 12524-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SAT2 protein levels (SeqId = 12524-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Diamine acetyltransferase 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000016 None Gadd-DA_sat2_protein_levels__seqid___12524-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 APOA1 protein levels (SeqId = 2750-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOA1 protein levels (SeqId = 2750-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein A-I 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.099 0.000016 None Gadd-DA_apoa1_protein_levels__seqid___2750-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NEU1 protein levels (SeqId = 15426-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NEU1 protein levels (SeqId = 15426-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialidase-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.429 0.099 0.000016 None Gadd-DA_neu1_protein_levels__seqid___15426-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SCARB2 protein levels (SeqId = 5100-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCARB2 protein levels (SeqId = 5100-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysosome membrane protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000016 None Gadd-DA_scarb2_protein_levels__seqid___5100-53__somascan_protein_measurement Cronjé HT Prospective Urban and Rural Epidemiology study 31910897 2020-01-07 Alcohol consumption EFO_0004329, NCIT_C16273 None Additional file 2a DNA methylation Alcohol consumption Age, body mass index, smoking, cell composition (reference based), batch effects Beta Values grams per day Illumina HumanMethylationEPIC Whole blood None 108 1 Adults Males African cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.00082 0.00018 0.000016 None 31910897_Cronjé-HT_alcohol_consumption Gadd DA Generation Scotland 35945220 31/07/2022 INSL5 protein levels (SeqId = 10462-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 INSL5 protein levels (SeqId = 10462-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like peptide INSL5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.099 0.000016 None Gadd-DA_insl5_protein_levels__seqid___10462-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SWAP70 protein levels (SeqId = 13552-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SWAP70 protein levels (SeqId = 13552-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Switch-associated protein 70 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000016 None Gadd-DA_swap70_protein_levels__seqid___13552-7__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.132283 0.0307321 0.00001683543 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 KLHL13 protein levels (SeqId = 12463-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLHL13 protein levels (SeqId = 12463-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kelch-like protein 13 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000017 None Gadd-DA_klhl13_protein_levels__seqid___12463-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SSR1 protein levels (SeqId = 8106-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SSR1 protein levels (SeqId = 8106-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Translocon-associated protein subunit alpha 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000017 None Gadd-DA_ssr1_protein_levels__seqid___8106-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KRT1 protein levels (SeqId = 9931-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT1 protein levels (SeqId = 9931-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type II cytoskeletal 1 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.69 0.161 0.000017 None Gadd-DA_krt1_protein_levels__seqid___9931-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.035452 0.00825138 0.00001746432 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CST8 protein levels (SeqId = 10572-65) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST8 protein levels (SeqId = 10572-65) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-8 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.1 0.000018 None Gadd-DA_cst8_protein_levels__seqid___10572-65__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MBL2 protein levels (SeqId = 3000-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MBL2 protein levels (SeqId = 3000-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mannose-binding protein C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.43 0.099 0.000018 None Gadd-DA_mbl2_protein_levels__seqid___3000-66__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea -0.0353291 0.00825142 0.00001867555 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HRK protein levels (SeqId = 8008-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HRK protein levels (SeqId = 8008-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activator of apoptosis harakiri 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000019 None Gadd-DA_hrk_protein_levels__seqid___8008-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TFIP11 protein levels (SeqId = 9043-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TFIP11 protein levels (SeqId = 9043-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tuftelin-interacting protein 11 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.43 0.099 0.000019 None Gadd-DA_tfip11_protein_levels__seqid___9043-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MEOX2 protein levels (SeqId = 18259-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MEOX2 protein levels (SeqId = 18259-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Homeobox protein MOX-2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000019 None Gadd-DA_meox2_protein_levels__seqid___18259-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 F9 protein levels (SeqId = 4876-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 F9 protein levels (SeqId = 4876-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coagulation factor IX 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000019 None Gadd-DA_f9_protein_levels__seqid___4876-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CST7 protein levels (SeqId = 3302-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CST7 protein levels (SeqId = 3302-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cystatin-F 774 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.61 0.143 0.00002 None Gadd-DA_cst7_protein_levels__seqid___3302-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ECE1 protein levels (SeqId = 8767-44) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ECE1 protein levels (SeqId = 8767-44) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endothelin-converting enzyme 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.00002 None Gadd-DA_ece1_protein_levels__seqid___8767-44__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADH1A protein levels (SeqId = 17396-23) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH1A protein levels (SeqId = 17396-23) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 1A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.00002 None Gadd-DA_adh1a_protein_levels__seqid___17396-23__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0325159 0.00762911 0.0000203796 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.035149 0.00825147 0.00002059571 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.12621 0.0296376 0.00002069508 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 APOL3 protein levels (SeqId = 16823-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOL3 protein levels (SeqId = 16823-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein L3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000021 None Gadd-DA_apol3_protein_levels__seqid___16823-75__somascan_protein_measurement Anna Ulrich None 38184627 Dec 5, 2023 Idiopathic/heritable pulmonary arterial hypertension None Discovery None DNA methylation Idiopathic/heritable pulmonary arterial hypertension Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes Beta values None Illumina HumanMethylationEPIC whole blood None 1655 4 Adults Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -17 4 0.000021 None 38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 645 1 63.2 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.033 0.008 0.000021 - 28173150_serum_triglycerides_discovery Gadd DA Generation Scotland 35945220 31/07/2022 GHR protein levels (SeqId = 2948-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GHR protein levels (SeqId = 2948-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth hormone receptor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000021 None Gadd-DA_ghr_protein_levels__seqid___2948-58__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0358847 0.00843727 0.00002121219 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.035026 0.00825151 0.00002201373 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0378395 0.00891994 0.00002227756 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0841271 0.0198564 0.00002279212 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.00055 0.00013 0.000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 STAP1 protein levels (SeqId = 12510-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STAP1 protein levels (SeqId = 12510-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal-transducing adaptor protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000023 None Gadd-DA_stap1_protein_levels__seqid___12510-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRKCG protein levels (SeqId = 5476-66) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRKCG protein levels (SeqId = 5476-66) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein kinase C gamma type 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000023 None Gadd-DA_prkcg_protein_levels__seqid___5476-66__somascan_protein_measurement Mamtani M - 26798409 2016-01-20 Hypertriglyceridemic waist EFO_0004342, EFO_0004530 - Table S2 Liability function of hypertriglyceridemic waist DNA methylation Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 850 1 46.8 Both None cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.22794816 0.05385 0.000023 - 26798409_hypertriglyceridemic_waist Gadd DA Generation Scotland 35945220 31/07/2022 CPB1 protein levels (SeqId = 15375-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPB1 protein levels (SeqId = 15375-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000023 None Gadd-DA_cpb1_protein_levels__seqid___15375-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NPIPB3 protein levels (SeqId = 9954-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPIPB3 protein levels (SeqId = 9954-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Nuclear pore complex-interacting protein family member B3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000023 None Gadd-DA_npipb3_protein_levels__seqid___9954-2__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea -0.0012 0.00029 0.000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0349104 0.00825154 0.00002343071 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0576938 0.0136397 0.0000235275 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0842512 0.0199288 0.00002374047 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Gadd DA Generation Scotland 35945220 31/07/2022 MLL2 protein levels (SeqId = 13623-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MLL2 protein levels (SeqId = 13623-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone-lysine N-methyltransferase 2D 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000024 None Gadd-DA_mll2_protein_levels__seqid___13623-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL36B protein levels (SeqId = 14149-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL36B protein levels (SeqId = 14149-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-36 beta 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000024 None Gadd-DA_il36b_protein_levels__seqid___14149-9__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KRT5 protein levels (SeqId = 11177-16) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT5 protein levels (SeqId = 11177-16) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type II cytoskeletal 5 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.68 0.16 0.000024 None Gadd-DA_krt5_protein_levels__seqid___11177-16__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.034828 0.00825156 0.0000244926 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1 Huang D BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY 32520614 2020-11-12 Diastolic Blood Pressure EFO_0006336 Discovery Table 2, table 3 DNA methylation Diastolic Blood Pressure age, sex, ancestry, body mass index, cell composition (reference based) Beta Values mmHg Illumina HumanMethylation450 Whole blood Includes some twins 4820 15 Adults Both European, Admixed cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000025 None 32520614_Huang-D_diastolic_blood_pressure_discovery Gadd DA Generation Scotland 35945220 31/07/2022 LMAN2 protein levels (SeqId = 7638-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LMAN2 protein levels (SeqId = 7638-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Vesicular integral-membrane protein VIP36 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000025 None Gadd-DA_lman2_protein_levels__seqid___7638-30__somascan_protein_measurement Battram T ARIES None 2020-08-20 Total cholesterol to total lipids ratio in large HDL EFO_0004574 None None DNA methylation Total cholesterol to total lipids ratio in large HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 678 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.042 0.0099 0.000025 None Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0358663 0.00852203 0.00002584252 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ARTN protein levels (SeqId = 2939-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARTN protein levels (SeqId = 2939-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Artemin 774 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.61 0.145 0.000026 None Gadd-DA_artn_protein_levels__seqid___2939-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RELT protein levels (SeqId = 14112-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RELT protein levels (SeqId = 14112-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor receptor superfamily member 19L 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000026 None Gadd-DA_relt_protein_levels__seqid___14112-40__somascan_protein_measurement Battram T ARIES None 2020-08-20 Cholesterol esters to total lipids ratio in large HDL EFO_0008589 None None DNA methylation Cholesterol esters to total lipids ratio in large HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 677 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.059 0.014 0.000026 None Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_hdl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0352211 0.00837355 0.00002612045 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0346669 0.00825161 0.00002670381 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0346556 0.00825161 0.00002686631 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CFB protein levels (SeqId = 4129-72) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFB protein levels (SeqId = 4129-72) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement factor B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000027 None Gadd-DA_cfb_protein_levels__seqid___4129-72__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TFPI protein levels (SeqId = 3336-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TFPI protein levels (SeqId = 3336-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tissue factor pathway inhibitor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000027 None Gadd-DA_tfpi_protein_levels__seqid___3336-50__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DAG1 protein levels (SeqId = 8369-102) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DAG1 protein levels (SeqId = 8369-102) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dystroglycan 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.68 0.161 0.000027 None Gadd-DA_dag1_protein_levels__seqid___8369-102__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0346073 0.00825163 0.00002756951 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0372517 0.0088846 0.00002771007 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0354025 0.00844709 0.00002792507 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Battram T ARIES None 2020-08-20 Triglycerides in small HDL EFO_0004530 None None DNA methylation Triglycerides in small HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -10.7 2.5 0.000028 None Battram-T_triglycerides_in_small_hdl Gadd DA Generation Scotland 35945220 31/07/2022 DAO protein levels (SeqId = 19120-33) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DAO protein levels (SeqId = 19120-33) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: D-amino-acid oxidase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000028 None Gadd-DA_dao_protein_levels__seqid___19120-33__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BCAR3 protein levels (SeqId = 12634-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BCAR3 protein levels (SeqId = 12634-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Breast cancer anti-estrogen resistance protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000028 None Gadd-DA_bcar3_protein_levels__seqid___12634-79__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0345733 0.00825164 0.00002807452 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.174163 0.0415988 0.00002843943 None 39706196_Hannah-M.-Smith_bmi_discovery Battram T ARIES None 2020-08-20 Monounsaturated fatty acids 16:1 18:1 EFO_0005110 None None DNA methylation Monounsaturated fatty acids 16:1 18:1 Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 667 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.207 0.049 0.000029 None Battram-T_monounsaturated_fatty_acids_16_1_18_1 Gadd DA Generation Scotland 35945220 31/07/2022 PLCG1 protein levels (SeqId = 4563-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PLCG1 protein levels (SeqId = 4563-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000029 None Gadd-DA_plcg1_protein_levels__seqid___4563-61__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NCR3 protein levels (SeqId = 3003-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NCR3 protein levels (SeqId = 3003-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Natural cytotoxicity triggering receptor 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000029 None Gadd-DA_ncr3_protein_levels__seqid___3003-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000029 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LGALS4 protein levels (SeqId = 2982-82) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LGALS4 protein levels (SeqId = 2982-82) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galectin-4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.099 0.000029 None Gadd-DA_lgals4_protein_levels__seqid___2982-82__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01009 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01009 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0349956 0.00836965 0.00002915941 P01009 41361833_Josephine_Robertson_P01009_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.034456 0.00825167 0.00002988588 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Battram T ARIES None 2020-08-20 Ratio of monounsaturated fatty acids to total fatty acids EFO_0005110 None None DNA methylation Ratio of monounsaturated fatty acids to total fatty acids Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 669 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.053 0.0125 0.00003 None Battram-T_ratio_of_monounsaturated_fatty_acids_to_total_fatty_acids Gadd DA Generation Scotland 35945220 31/07/2022 PTPRH protein levels (SeqId = 11988-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTPRH protein levels (SeqId = 11988-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor-type tyrosine-protein phosphatase H 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.00003 None Gadd-DA_ptprh_protein_levels__seqid___11988-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADI1 protein levels (SeqId = 12457-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADI1 protein levels (SeqId = 12457-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.00003 None Gadd-DA_adi1_protein_levels__seqid___12457-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ITGB5 protein levels (SeqId = 7755-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ITGB5 protein levels (SeqId = 7755-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Integrin beta-5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.00003 None Gadd-DA_itgb5_protein_levels__seqid___7755-37__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0570727 0.0136849 0.00003057082 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0344089 0.00825168 0.00003064431 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea -0.0344006 0.00825168 0.0000307803 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 POR protein levels (SeqId = 2731-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POR protein levels (SeqId = 2731-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NADPH--cytochrome P450 reductase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.42 0.1 0.000031 None Gadd-DA_por_protein_levels__seqid___2731-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CENPV protein levels (SeqId = 8817-29) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CENPV protein levels (SeqId = 8817-29) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Centromere protein V 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000031 None Gadd-DA_cenpv_protein_levels__seqid___8817-29__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TNFSF14 protein levels (SeqId = 5988-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFSF14 protein levels (SeqId = 5988-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor ligand superfamily member 14 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.415 0.1 0.000031 None Gadd-DA_tnfsf14_protein_levels__seqid___5988-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SUFU protein levels (SeqId = 17468-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUFU protein levels (SeqId = 17468-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Suppressor of fused homolog 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000031 None Gadd-DA_sufu_protein_levels__seqid___17468-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0416844 0.0100088 0.00003134384 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0347341 0.00834925 0.00003198522 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Battram T ARIES None 2020-08-20 Body mass index EFO_0004340 None None DNA methylation Body mass index Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 714 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.029 0.0069 0.000032 None Battram-T_body_mass_index Gadd DA Generation Scotland 35945220 31/07/2022 PUF60 protein levels (SeqId = 10575-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PUF60 protein levels (SeqId = 10575-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Poly(U)-binding-splicing factor PUF60 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000032 None Gadd-DA_puf60_protein_levels__seqid___10575-31__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GPD1 protein levels (SeqId = 13697-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPD1 protein levels (SeqId = 13697-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000032 None Gadd-DA_gpd1_protein_levels__seqid___13697-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHEK1 protein levels (SeqId = 2853-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHEK1 protein levels (SeqId = 2853-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein kinase Chk1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000032 None Gadd-DA_chek1_protein_levels__seqid___2853-68__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.034282 0.00825172 0.00003278124 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TNFRSF6B protein levels (SeqId = 5070-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TNFRSF6B protein levels (SeqId = 5070-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tumor necrosis factor receptor superfamily member 6B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.413 0.1 0.000033 None Gadd-DA_tnfrsf6b_protein_levels__seqid___5070-76__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BLNK protein levels (SeqId = 19225-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BLNK protein levels (SeqId = 19225-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: B-cell linker protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000033 None Gadd-DA_blnk_protein_levels__seqid___19225-11__somascan_protein_measurement Battram T ARIES None 2020-08-20 Total cholesterol to total lipids ratio in medium HDL EFO_0004574 None None DNA methylation Total cholesterol to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.073 0.0175 0.000033 None Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_hdl Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.041 0.00989 0.000033 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 TMCC3 protein levels (SeqId = 8922-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMCC3 protein levels (SeqId = 8922-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane and coiled-coil domain protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000034 None Gadd-DA_tmcc3_protein_levels__seqid___8922-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FCRL3 protein levels (SeqId = 4440-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCRL3 protein levels (SeqId = 4440-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fc receptor-like protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000034 None Gadd-DA_fcrl3_protein_levels__seqid___4440-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0370507 0.0089376 0.0000341011 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 GLTPD2 protein levels (SeqId = 7948-129) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GLTPD2 protein levels (SeqId = 7948-129) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycolipid transfer protein domain-containing protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000035 None Gadd-DA_gltpd2_protein_levels__seqid___7948-129__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05371417 chr4:139113574 4 139113574 SLC7A11 Open sea 0.0341275 0.00825176 0.00003557097 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADH1B protein levels (SeqId = 9834-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH1B protein levels (SeqId = 9834-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 1B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000036 None Gadd-DA_adh1b_protein_levels__seqid___9834-62__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PKDCC protein levels (SeqId = 8664-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PKDCC protein levels (SeqId = 8664-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Extracellular tyrosine-protein kinase PKDCC 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000036 None Gadd-DA_pkdcc_protein_levels__seqid___8664-36__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KLRC3 protein levels (SeqId = 7795-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLRC3 protein levels (SeqId = 7795-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: NKG2-E type II integral membrane protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000036 None Gadd-DA_klrc3_protein_levels__seqid___7795-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0343686 0.00832509 0.00003674536 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Battram T ARIES None 2020-08-20 Triglycerides in medium HDL EFO_0004530 None None DNA methylation Triglycerides in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -10.4 2.5 0.000037 None Battram-T_triglycerides_in_medium_hdl Battram T ARIES None 2020-08-20 Triglycerides to total lipids ratio in small LDL EFO_0004530 None None DNA methylation Triglycerides to total lipids ratio in small LDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.086 0.0208 0.000037 None Battram-T_triglycerides_to_total_lipids_ratio_in_small_ldl Gadd DA Generation Scotland 35945220 31/07/2022 HAPLN4 protein levels (SeqId = 6455-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HAPLN4 protein levels (SeqId = 6455-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hyaluronan and proteoglycan link protein 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000037 None Gadd-DA_hapln4_protein_levels__seqid___6455-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNGT2 protein levels (SeqId = 10917-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNGT2 protein levels (SeqId = 10917-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000037 None Gadd-DA_gngt2_protein_levels__seqid___10917-40__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PALM protein levels (SeqId = 18306-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PALM protein levels (SeqId = 18306-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Paralemmin-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000037 None Gadd-DA_palm_protein_levels__seqid___18306-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0340483 0.00825178 0.00003708755 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0340369 0.00825179 0.00003731092 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea -0.0340766 0.00826339 0.00003747155 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0344 0.00834523 0.00003774861 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 MACROD1 protein levels (SeqId = 13653-335) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MACROD1 protein levels (SeqId = 13653-335) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribose glycohydrolase MACROD1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000038 None Gadd-DA_macrod1_protein_levels__seqid___13653-335__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLC35G2 protein levels (SeqId = 13501-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLC35G2 protein levels (SeqId = 13501-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Solute carrier family 35 member G2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000038 None Gadd-DA_slc35g2_protein_levels__seqid___13501-10__somascan_protein_measurement Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg15441006 chr4:139110589 4 139110589 SLC7A11 Open sea None None 0.000038 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0350971 0.00852107 0.00003828439 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0339762 0.0082518 0.00003852211 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Battram T ARIES None 2020-08-20 Glycoprotein acetyls EFO_0004555 None None DNA methylation Glycoprotein acetyls Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.93 0.22 0.000039 None Battram-T_glycoprotein_acetyls Gadd DA Generation Scotland 35945220 31/07/2022 BRPF1 protein levels (SeqId = 11671-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BRPF1 protein levels (SeqId = 11671-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peregrin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000039 None Gadd-DA_brpf1_protein_levels__seqid___11671-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKR1C4 protein levels (SeqId = 18397-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR1C4 protein levels (SeqId = 18397-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aldo-keto reductase family 1 member C4 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.66 0.161 0.000039 None Gadd-DA_akr1c4_protein_levels__seqid___18397-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0339518 0.00825181 0.00003901856 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Osteoarthritis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Osteoarthritis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 16114 1 Adults (18-65y) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea 0.05 0.01225 0.00004 None Robert-F-Hillary_Incident_Osteoarthritis_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 BDP1 protein levels (SeqId = 8929-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BDP1 protein levels (SeqId = 8929-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transcription factor TFIIIB component B'' homolog 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.00004 None Gadd-DA_bdp1_protein_levels__seqid___8929-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C8A protein levels (SeqId = 2429-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C8A protein levels (SeqId = 2429-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement component C8 beta chain|Complement component C8 gamma chain|Complement component C8 alpha chain 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.00004 None Gadd-DA_c8a_protein_levels__seqid___2429-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ASIC4 protein levels (SeqId = 6951-26) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ASIC4 protein levels (SeqId = 6951-26) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Acid-sensing ion channel 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.409 0.1 0.00004 None Gadd-DA_asic4_protein_levels__seqid___6951-26__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADAMTS15 protein levels (SeqId = 4533-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAMTS15 protein levels (SeqId = 4533-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: A disintegrin and metalloproteinase with thrombospondin motifs 15 774 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.59 0.144 0.000041 None Gadd-DA_adamts15_protein_levels__seqid___4533-76__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AGR2 protein levels (SeqId = 4959-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGR2 protein levels (SeqId = 4959-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Anterior gradient protein 2 homolog 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000041 None Gadd-DA_agr2_protein_levels__seqid___4959-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TERF1 protein levels (SeqId = 10049-112) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TERF1 protein levels (SeqId = 10049-112) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Telomeric repeat-binding factor 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.408 0.1 0.000041 None Gadd-DA_terf1_protein_levels__seqid___10049-112__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PROL1 protein levels (SeqId = 6530-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PROL1 protein levels (SeqId = 6530-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Opiorphin prepropeptide 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000041 None Gadd-DA_prol1_protein_levels__seqid___6530-63__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UGDH protein levels (SeqId = 17755-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UGDH protein levels (SeqId = 17755-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UDP-glucose 6-dehydrogenase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.408 0.1 0.000042 None Gadd-DA_ugdh_protein_levels__seqid___17755-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CREB3L2 protein levels (SeqId = 17336-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CREB3L2 protein levels (SeqId = 17336-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cyclic AMP-responsive element-binding protein 3-like protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000042 None Gadd-DA_creb3l2_protein_levels__seqid___17336-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PPIB protein levels (SeqId = 4718-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PPIB protein levels (SeqId = 4718-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptidyl-prolyl cis-trans isomerase B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000043 None Gadd-DA_ppib_protein_levels__seqid___4718-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PYCR2 protein levels (SeqId = 18328-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PYCR2 protein levels (SeqId = 18328-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pyrroline-5-carboxylate reductase 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000043 None Gadd-DA_pycr2_protein_levels__seqid___18328-36__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0337317 0.00825187 0.00004378622 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ADAM10 protein levels (SeqId = 8654-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAM10 protein levels (SeqId = 8654-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 10 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.099 0.000044 None Gadd-DA_adam10_protein_levels__seqid___8654-13__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.036277 0.00888691 0.00004487334 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 GUSB protein levels (SeqId = 15562-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GUSB protein levels (SeqId = 15562-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-glucuronidase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000045 None Gadd-DA_gusb_protein_levels__seqid___15562-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RCL protein levels (SeqId = 17785-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RCL protein levels (SeqId = 17785-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000045 None Gadd-DA_rcl_protein_levels__seqid___17785-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 WFDC5 protein levels (SeqId = 6969-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 WFDC5 protein levels (SeqId = 6969-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: WAP four-disulfide core domain protein 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000045 None Gadd-DA_wfdc5_protein_levels__seqid___6969-14__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0397842 0.00975798 0.00004584184 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 IQCF1 protein levels (SeqId = 7991-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IQCF1 protein levels (SeqId = 7991-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: IQ domain-containing protein F1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000046 None Gadd-DA_iqcf1_protein_levels__seqid___7991-54__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADAMTSL2 protein levels (SeqId = 6379-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAMTSL2 protein levels (SeqId = 6379-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADAMTS-like protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000046 None Gadd-DA_adamtsl2_protein_levels__seqid___6379-62__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0340195 0.00835348 0.00004675589 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0346914 0.00851925 0.00004683227 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 RBM23 protein levels (SeqId = 11590-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBM23 protein levels (SeqId = 11590-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Probable RNA-binding protein 23 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000047 None Gadd-DA_rbm23_protein_levels__seqid___11590-5__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 OSCAR protein levels (SeqId = 7116-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OSCAR protein levels (SeqId = 7116-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Osteoclast-associated immunoglobulin-like receptor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.41 0.1 0.000047 None Gadd-DA_oscar_protein_levels__seqid___7116-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0546985 0.0134406 0.00004732783 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GLP1R protein levels (SeqId = 13085-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GLP1R protein levels (SeqId = 13085-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glucagon-like peptide 1 receptor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000048 None Gadd-DA_glp1r_protein_levels__seqid___13085-18__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AGAP3 protein levels (SeqId = 13960-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AGAP3 protein levels (SeqId = 13960-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000048 None Gadd-DA_agap3_protein_levels__seqid___13960-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0339638 0.00835811 0.00004857943 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GAL protein levels (SeqId = 15390-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GAL protein levels (SeqId = 15390-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Galanin peptides 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000049 None Gadd-DA_gal_protein_levels__seqid___15390-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPINK4 protein levels (SeqId = 19213-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPINK4 protein levels (SeqId = 19213-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine protease inhibitor Kazal-type 4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000049 None Gadd-DA_spink4_protein_levels__seqid___19213-1__somascan_protein_measurement Battram T ARIES None 2020-08-20 Cholesterol esters in large VLDL EFO_0008589 None None DNA methylation Cholesterol esters in large VLDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 661 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -8.7 2.13 0.00005 None Battram-T_cholesterol_esters_in_large_vldl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0339173 0.00836213 0.00005016579 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0334491 0.00825195 0.00005072186 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GJD2 protein levels (SeqId = 11678-105) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GJD2 protein levels (SeqId = 11678-105) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Gap junction delta-2 protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000051 None Gadd-DA_gjd2_protein_levels__seqid___11678-105__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RERG protein levels (SeqId = 17822-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RERG protein levels (SeqId = 17822-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ras-related and estrogen-regulated growth inhibitor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000051 None Gadd-DA_rerg_protein_levels__seqid___17822-57__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SERPIND1 protein levels (SeqId = 3316-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPIND1 protein levels (SeqId = 3316-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparin cofactor 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000051 None Gadd-DA_serpind1_protein_levels__seqid___3316-58__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RAPGEF5 protein levels (SeqId = 9059-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RAPGEF5 protein levels (SeqId = 9059-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Rap guanine nucleotide exchange factor 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000052 None Gadd-DA_rapgef5_protein_levels__seqid___9059-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CBX5 protein levels (SeqId = 4540-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CBX5 protein levels (SeqId = 4540-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chromobox protein homolog 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000052 None Gadd-DA_cbx5_protein_levels__seqid___4540-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ACVR2B protein levels (SeqId = 9412-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACVR2B protein levels (SeqId = 9412-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Activin receptor type-2B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000052 None Gadd-DA_acvr2b_protein_levels__seqid___9412-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SMEK1 protein levels (SeqId = 10866-60) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMEK1 protein levels (SeqId = 10866-60) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Serine/threonine-protein phosphatase 4 regulatory subunit 3A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000052 None Gadd-DA_smek1_protein_levels__seqid___10866-60__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SPAST protein levels (SeqId = 8388-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SPAST protein levels (SeqId = 8388-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Spastin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000052 None Gadd-DA_spast_protein_levels__seqid___8388-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CTRB2 protein levels (SeqId = 5648-28) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTRB2 protein levels (SeqId = 5648-28) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chymotrypsinogen B2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000053 None Gadd-DA_ctrb2_protein_levels__seqid___5648-28__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLCO5A1 protein levels (SeqId = 11669-39) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLCO5A1 protein levels (SeqId = 11669-39) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Solute carrier organic anion transporter family member 5A1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000053 None Gadd-DA_slco5a1_protein_levels__seqid___11669-39__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FUT9 protein levels (SeqId = 6991-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FUT9 protein levels (SeqId = 6991-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-(1,3)-fucosyltransferase 9 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000053 None Gadd-DA_fut9_protein_levels__seqid___6991-24__somascan_protein_measurement Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -1.3 0.332 0.000053 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea -0.0333441 0.00825198 0.00005355573 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CTRB1 protein levels (SeqId = 5671-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTRB1 protein levels (SeqId = 5671-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chymotrypsinogen B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000054 None Gadd-DA_ctrb1_protein_levels__seqid___5671-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GDNF protein levels (SeqId = 5822-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDNF protein levels (SeqId = 5822-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glial cell line-derived neurotrophic factor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000054 None Gadd-DA_gdnf_protein_levels__seqid___5822-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EDF1 protein levels (SeqId = 12415-122) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EDF1 protein levels (SeqId = 12415-122) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Endothelial differentiation-related factor 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000054 None Gadd-DA_edf1_protein_levels__seqid___12415-122__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GNMT protein levels (SeqId = 14006-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GNMT protein levels (SeqId = 14006-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycine N-methyltransferase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000054 None Gadd-DA_gnmt_protein_levels__seqid___14006-36__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0333251 0.00825199 0.000054084 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.0333109 0.00825199 0.00005448156 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LECT2 protein levels (SeqId = 16763-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LECT2 protein levels (SeqId = 16763-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leukocyte cell-derived chemotaxin-2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.401 0.099 0.000055 None Gadd-DA_lect2_protein_levels__seqid___16763-11__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0332623 0.008252 0.00005586338 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0337292 0.00836843 0.00005593381 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.125867 0.0312505 0.00005657201 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09021112 chr4:139164790 4 139164790 SLC7A11 Open sea 0.0332281 0.00825201 0.00005685909 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MAD1L1 protein levels (SeqId = 13618-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MAD1L1 protein levels (SeqId = 13618-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mitotic spindle assembly checkpoint protein MAD1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000057 None Gadd-DA_mad1l1_protein_levels__seqid___13618-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0341585 0.00848747 0.00005736438 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 UBC protein levels (SeqId = 6647-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBC protein levels (SeqId = 6647-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polyubiquitin-C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000058 None Gadd-DA_ubc_protein_levels__seqid___6647-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RGS3 protein levels (SeqId = 12827-37) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RGS3 protein levels (SeqId = 12827-37) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Regulator of G-protein signaling 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000058 None Gadd-DA_rgs3_protein_levels__seqid___12827-37__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 F3 protein levels (SeqId = 4931-59) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 F3 protein levels (SeqId = 4931-59) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tissue factor 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000058 None Gadd-DA_f3_protein_levels__seqid___4931-59__somascan_protein_measurement Battram T ARIES None 2020-08-20 Ribs bone mineral density EFO_0007591 None None DNA methylation Ribs bone mineral density Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g/cm2 Illumina HumanMethylation450 Whole blood DXA scan measurement 702 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -1.92 0.48 0.000058 None Battram-T_ribs_bone_mineral_density Gadd DA Generation Scotland 35945220 31/07/2022 UBE2A protein levels (SeqId = 17743-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2A protein levels (SeqId = 17743-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000058 None Gadd-DA_ube2a_protein_levels__seqid___17743-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 EVA1C protein levels (SeqId = 8877-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EVA1C protein levels (SeqId = 8877-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein eva-1 homolog C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000058 None Gadd-DA_eva1c_protein_levels__seqid___8877-22__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea -0.0331733 0.00825203 0.00005848587 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0331664 0.00825203 0.00005869241 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 RARRES2 protein levels (SeqId = 3079-62) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RARRES2 protein levels (SeqId = 3079-62) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinoic acid receptor responder protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.00006 None Gadd-DA_rarres2_protein_levels__seqid___3079-62__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CRIM1 protein levels (SeqId = 15492-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CRIM1 protein levels (SeqId = 15492-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cysteine-rich motor neuron 1 protein 774 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.73 0.181 0.00006 None Gadd-DA_crim1_protein_levels__seqid___15492-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0342688 0.00854288 0.00006066395 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0338476 0.00844127 0.00006107739 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CARD17 protein levels (SeqId = 18267-74) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CARD17 protein levels (SeqId = 18267-74) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Caspase recruitment domain-containing protein 17 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000062 None Gadd-DA_card17_protein_levels__seqid___18267-74__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0330384 0.00825206 0.00006267804 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.0330294 0.00825207 0.00006296938 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CARD18 protein levels (SeqId = 18190-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CARD18 protein levels (SeqId = 18190-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Caspase recruitment domain-containing protein 18 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000064 None Gadd-DA_card18_protein_levels__seqid___18190-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 DCAF5 protein levels (SeqId = 11283-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 DCAF5 protein levels (SeqId = 11283-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: DDB1- and CUL4-associated factor 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000064 None Gadd-DA_dcaf5_protein_levels__seqid___11283-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARMC5 protein levels (SeqId = 8785-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARMC5 protein levels (SeqId = 8785-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Armadillo repeat-containing protein 5 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000064 None Gadd-DA_armc5_protein_levels__seqid___8785-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UBE2G2 protein levels (SeqId = 9199-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UBE2G2 protein levels (SeqId = 9199-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ubiquitin-conjugating enzyme E2 G2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.099 0.000064 None Gadd-DA_ube2g2_protein_levels__seqid___9199-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0577101 0.0144325 0.00006402561 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0333501 0.00834774 0.00006498229 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GALE protein levels (SeqId = 11457-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GALE protein levels (SeqId = 11457-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UDP-glucose 4-epimerase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000065 None Gadd-DA_gale_protein_levels__seqid___11457-53__somascan_protein_measurement Battram T ARIES None 2020-08-20 Serum total triglycerides EFO_0004530 None None DNA methylation Serum total triglycerides Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 676 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.31 0.076 0.000065 None Battram-T_serum_total_triglycerides Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.108608 0.0271932 0.00006525632 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea -0.0329337 0.00825209 0.00006612781 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21877274 chr4:139107328 4 139107328 SLC7A11 Open sea 0.0329199 0.0082521 0.00006659671 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.033379 0.00836853 0.0000667778 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Battram T GEO 27886173 2020-09-15 Ulcerative colitis EFO_0000729 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Ulcerative colitis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 163 1 Adults Both European cg00534274 chr4:139163341 4 139163341 SLC7A11 Open sea 0.0354 0.00862 0.000067 None 27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Gadd DA Generation Scotland 35945220 31/07/2022 PILRA protein levels (SeqId = 8825-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PILRA protein levels (SeqId = 8825-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Paired immunoglobulin-like type 2 receptor alpha 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000067 None Gadd-DA_pilra_protein_levels__seqid___8825-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF17 protein levels (SeqId = 3494-71) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF17 protein levels (SeqId = 3494-71) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 17 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000068 None Gadd-DA_fgf17_protein_levels__seqid___3494-71__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0058 0.00144 0.000068 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 RNF128 protein levels (SeqId = 8633-18) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF128 protein levels (SeqId = 8633-18) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: E3 ubiquitin-protein ligase RNF128 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000068 None Gadd-DA_rnf128_protein_levels__seqid___8633-18__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 0.022 0.00562 0.000068 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 CSDC2 protein levels (SeqId = 12754-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CSDC2 protein levels (SeqId = 12754-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cold shock domain-containing protein C2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000069 None Gadd-DA_csdc2_protein_levels__seqid___12754-14__somascan_protein_measurement Battram T ARIES None 2020-08-20 Cholesterol esters to total lipids ratio in medium HDL EFO_0008589 None None DNA methylation Cholesterol esters to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.07 0.0175 0.000069 None Battram-T_cholesterol_esters_to_total_lipids_ratio_in_medium_hdl Gadd DA Generation Scotland 35945220 31/07/2022 CLPSL2 protein levels (SeqId = 7767-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CLPSL2 protein levels (SeqId = 7767-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Colipase-like protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000069 None Gadd-DA_clpsl2_protein_levels__seqid___7767-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0337187 0.00848256 0.00007069903 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 GULP1 protein levels (SeqId = 19180-38) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GULP1 protein levels (SeqId = 19180-38) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: PTB domain-containing engulfment adapter protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000073 None Gadd-DA_gulp1_protein_levels__seqid___19180-38__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 NPPB protein levels (SeqId = 16751-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NPPB protein levels (SeqId = 16751-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Natriuretic peptides B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000073 None Gadd-DA_nppb_protein_levels__seqid___16751-15__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GDF3 protein levels (SeqId = 16755-195) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GDF3 protein levels (SeqId = 16755-195) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Growth/differentiation factor 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.4 0.1 0.000073 None Gadd-DA_gdf3_protein_levels__seqid___16755-195__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PNLIPRP1 protein levels (SeqId = 6627-25) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PNLIPRP1 protein levels (SeqId = 6627-25) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inactive pancreatic lipase-related protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000073 None Gadd-DA_pnliprp1_protein_levels__seqid___6627-25__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNPC3 protein levels (SeqId = 12814-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNPC3 protein levels (SeqId = 12814-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RNA-binding region-containing protein 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.395 0.1 0.000073 None Gadd-DA_rnpc3_protein_levels__seqid___12814-17__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CHI3L1 protein levels (SeqId = 11104-13) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CHI3L1 protein levels (SeqId = 11104-13) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Chitinase-3-like protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000074 None Gadd-DA_chi3l1_protein_levels__seqid___11104-13__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BDH2 protein levels (SeqId = 17329-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BDH2 protein levels (SeqId = 17329-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-hydroxybutyrate dehydrogenase type 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000074 None Gadd-DA_bdh2_protein_levels__seqid___17329-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04474257 chr4:139147773 4 139147773 SLC7A11 Open sea -0.0327101 0.00825215 0.00007410757 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0385627 0.00973133 0.00007444553 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg04487857 chr4:139096540 4 139096540 SLC7A11 Open sea 0.170302 0.0429884 0.0000747526 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Jia T ENIGMA consortium 31811260 2010-12-06 Thalamus volume None None Table S2 Thalamus volume DNA methylation Age, sex, intracranial volume, methylation composition, cell composition (reference free), batch effects, disease status mm^3 per effect allele Beta Values Illumina HumanMethylation450 Whole blood None 3337 9 Adults Both Unclear cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000075 None 31811260_Jia-T_thalamus_volume Gadd DA Generation Scotland 35945220 31/07/2022 IL17C protein levels (SeqId = 9255-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL17C protein levels (SeqId = 9255-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-17C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000075 None Gadd-DA_il17c_protein_levels__seqid___9255-5__somascan_protein_measurement Wilson LE Sister Study 30938765 2019-02-14 Alcohol Consumption EFO_0004329, EFO_0007878 replication Web Table 1 DNA methylation Alcohol Consumption Age, breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based) M Values drinks per week Illumina HumanMethylation450 Whole blood Discovery P-value not reported 187 1 Adults Females Unclear cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea None None 0.000075 None 30938765_Wilson-LE_alcohol_consumption_replication Gadd DA Generation Scotland 35945220 31/07/2022 AFM protein levels (SeqId = 4763-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AFM protein levels (SeqId = 4763-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Afamin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000076 None Gadd-DA_afm_protein_levels__seqid___4763-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0328722 0.008309 0.00007650347 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 STMN4 protein levels (SeqId = 6267-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 STMN4 protein levels (SeqId = 6267-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Stathmin-4 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.393 0.099 0.000077 None Gadd-DA_stmn4_protein_levels__seqid___6267-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 FGF1 protein levels (SeqId = 3486-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FGF1 protein levels (SeqId = 3486-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fibroblast growth factor 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000077 None Gadd-DA_fgf1_protein_levels__seqid___3486-58__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0334864 0.00847293 0.00007781015 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GALNT1 protein levels (SeqId = 7090-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GALNT1 protein levels (SeqId = 7090-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Polypeptide N-acetylgalactosaminyltransferase 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000078 None Gadd-DA_galnt1_protein_levels__seqid___7090-17__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14076 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.016 0.00396 0.000079 None Robert-F-Hillary_Incident_COPD_Fully-adjusted_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Ischemic Heart Disease None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Ischemic Heart Disease Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17483 1 Adults (18-65y) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.017 0.00424 0.000079 None Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model Gadd DA Generation Scotland 35945220 31/07/2022 SLPI protein levels (SeqId = 4413-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLPI protein levels (SeqId = 4413-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Antileukoproteinase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000079 None Gadd-DA_slpi_protein_levels__seqid___4413-3__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ERLIN1 protein levels (SeqId = 8776-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERLIN1 protein levels (SeqId = 8776-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Erlin-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000079 None Gadd-DA_erlin1_protein_levels__seqid___8776-10__somascan_protein_measurement Canouil M FinnGeDi 34116986 07-01-2021 Gestational diabetes mellitus EFO_0004593 EWAS in offspring Supplementary Table 3 DNA methylation Gestational diabetes mellitus Sex, Gestational age, Birthweight, cell composition (reference based) M values None Illumina HumanMethylationEPIC cord blood None 536 1 Infants Both European cg05726013 chr4:139156827 4 139156827 SLC7A11 Open sea -0.191 0.048 0.000079 None 34116986_Canouil-M_gestational_diabetes_mellitus_ewas_in_offspring Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0325804 0.00825219 0.00007914428 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea 0.0325741 0.00825219 0.00007939517 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13028471 chr4:139163535 4 139163535 SLC7A11 Open sea 0.0325639 0.00825219 0.00007980779 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 KNG1 protein levels (SeqId = 7784-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KNG1 protein levels (SeqId = 7784-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kininogen-1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.00008 None Gadd-DA_kng1_protein_levels__seqid___7784-1__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CFAP45 protein levels (SeqId = 6553-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CFAP45 protein levels (SeqId = 6553-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cilia- and flagella-associated protein 45 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000081 None Gadd-DA_cfap45_protein_levels__seqid___6553-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MYNN protein levels (SeqId = 12455-48) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MYNN protein levels (SeqId = 12455-48) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myoneurin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000081 None Gadd-DA_mynn_protein_levels__seqid___12455-48__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SLC26A5 protein levels (SeqId = 9127-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SLC26A5 protein levels (SeqId = 9127-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prestin 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000081 None Gadd-DA_slc26a5_protein_levels__seqid___9127-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RB1 protein levels (SeqId = 5024-67) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RB1 protein levels (SeqId = 5024-67) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinoblastoma-associated protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000082 None Gadd-DA_rb1_protein_levels__seqid___5024-67__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MICB protein levels (SeqId = 5102-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MICB protein levels (SeqId = 5102-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MHC class I polypeptide-related sequence B 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000082 None Gadd-DA_micb_protein_levels__seqid___5102-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TLL1 protein levels (SeqId = 6383-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TLL1 protein levels (SeqId = 6383-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tolloid-like protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000082 None Gadd-DA_tll1_protein_levels__seqid___6383-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL10A1 protein levels (SeqId = 15653-9) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL10A1 protein levels (SeqId = 15653-9) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(X) chain 774 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.71 0.181 0.000082 None Gadd-DA_col10a1_protein_levels__seqid___15653-9__somascan_protein_measurement Battram T ARIES None 2020-08-20 Triglycerides to total lipids ratio in medium HDL EFO_0004530 None None DNA methylation Triglycerides to total lipids ratio in medium HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values None Illumina HumanMethylation450 Whole blood None 683 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.107 0.027 0.000084 None Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl Gadd DA Generation Scotland 35945220 31/07/2022 ERBB3 protein levels (SeqId = 2617-56) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ERBB3 protein levels (SeqId = 2617-56) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Receptor tyrosine-protein kinase erbB-3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000084 None Gadd-DA_erbb3_protein_levels__seqid___2617-56__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.0324562 0.00825222 0.00008426973 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0333004 0.00847027 0.00008482455 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Anna Ulrich None 38184627 Dec 5, 2023 Idiopathic/heritable pulmonary arterial hypertension None Discovery None DNA methylation Idiopathic/heritable pulmonary arterial hypertension Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes Beta values None Illumina HumanMethylationEPIC whole blood None 1655 4 Adults Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea 9.4 2.4 0.000086 None 38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.032627 0.00830906 0.00008652148 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 ZNF566 protein levels (SeqId = 12795-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF566 protein levels (SeqId = 12795-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 566 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000087 None Gadd-DA_znf566_protein_levels__seqid___12795-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PFDN1 protein levels (SeqId = 19242-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PFDN1 protein levels (SeqId = 19242-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prefoldin subunit 1 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.63 0.161 0.000087 None Gadd-DA_pfdn1_protein_levels__seqid___19242-21__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0323776 0.00825224 0.00008767306 A0A0B4J1V2 41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 IFNA16 protein levels (SeqId = 6421-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IFNA16 protein levels (SeqId = 6421-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interferon alpha-16 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000088 None Gadd-DA_ifna16_protein_levels__seqid___6421-52__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 UGP2 protein levels (SeqId = 13939-14) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 UGP2 protein levels (SeqId = 13939-14) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: UTP--glucose-1-phosphate uridylyltransferase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000088 None Gadd-DA_ugp2_protein_levels__seqid___13939-14__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MARCO protein levels (SeqId = 9003-99) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MARCO protein levels (SeqId = 9003-99) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Macrophage receptor MARCO 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000088 None Gadd-DA_marco_protein_levels__seqid___9003-99__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 TXNIP protein levels (SeqId = 11682-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TXNIP protein levels (SeqId = 11682-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Thioredoxin-interacting protein 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000088 None Gadd-DA_txnip_protein_levels__seqid___11682-7__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ADAMTS15 protein levels (SeqId = 4533-76) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADAMTS15 protein levels (SeqId = 4533-76) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: A disintegrin and metalloproteinase with thrombospondin motifs 15 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000088 None Gadd-DA_adamts15_protein_levels__seqid___4533-76__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea -0.0323622 0.00825225 0.00008835579 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0323596 0.00825225 0.00008847172 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11788572 chr4:139111673 4 139111673 SLC7A11 Open sea 0.0542665 0.0138432 0.00008891857 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 HSPA1A protein levels (SeqId = 4124-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HSPA1A protein levels (SeqId = 4124-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heat shock 70 kDa protein 1A 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000089 None Gadd-DA_hspa1a_protein_levels__seqid___4124-24__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CD14 protein levels (SeqId = 8969-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD14 protein levels (SeqId = 8969-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Monocyte differentiation antigen CD14 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000089 None Gadd-DA_cd14_protein_levels__seqid___8969-49__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 LGI3 protein levels (SeqId = 8003-57) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LGI3 protein levels (SeqId = 8003-57) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Leucine-rich repeat LGI family member 3 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000089 None Gadd-DA_lgi3_protein_levels__seqid___8003-57__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0323436 0.00825225 0.00008918402 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -1.1 0.274 0.00009 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 FAH protein levels (SeqId = 11424-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FAH protein levels (SeqId = 11424-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fumarylacetoacetase 774 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.63 0.161 0.00009 None Gadd-DA_fah_protein_levels__seqid___11424-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ZNF843 protein levels (SeqId = 8321-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF843 protein levels (SeqId = 8321-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 843 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000091 None Gadd-DA_znf843_protein_levels__seqid___8321-27__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ARFGAP1 protein levels (SeqId = 11556-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ARFGAP1 protein levels (SeqId = 11556-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosylation factor GTPase-activating protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000091 None Gadd-DA_arfgap1_protein_levels__seqid___11556-19__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea 0.0332208 0.0084889 0.00009140091 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.0368985 0.00943065 0.00009171321 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ZNF415 protein levels (SeqId = 12811-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ZNF415 protein levels (SeqId = 12811-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Zinc finger protein 415 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000092 None Gadd-DA_znf415_protein_levels__seqid___12811-55__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KIAA1644 protein levels (SeqId = 10432-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KIAA1644 protein levels (SeqId = 10432-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Protein shisa-like-1 774 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.71 0.181 0.000093 None Gadd-DA_kiaa1644_protein_levels__seqid___10432-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07109838 chr4:139106603 4 139106603 SLC7A11 Open sea 0.0322538 0.00825228 0.00009329986 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SUV420H2 protein levels (SeqId = 12452-32) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SUV420H2 protein levels (SeqId = 12452-32) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Histone-lysine N-methyltransferase KMT5C 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000094 None Gadd-DA_suv420h2_protein_levels__seqid___12452-32__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RNF24 protein levels (SeqId = 9583-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RNF24 protein levels (SeqId = 9583-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: RING finger protein 24 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000094 None Gadd-DA_rnf24_protein_levels__seqid___9583-17__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13903162 chr4:139163019 4 139163019 SLC7A11 Open sea -0.032232 0.00825228 0.00009432601 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SYTL1 protein levels (SeqId = 12892-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SYTL1 protein levels (SeqId = 12892-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Synaptotagmin-like protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000095 None Gadd-DA_sytl1_protein_levels__seqid___12892-10__somascan_protein_measurement Battram T ARIES None 2020-08-20 Trunk tissue mass None None None DNA methylation Trunk tissue mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 699 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.000017 0.0000044 0.000095 None Battram-T_trunk_tissue_mass Gadd DA Generation Scotland 35945220 31/07/2022 MTMR1 protein levels (SeqId = 11167-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MTMR1 protein levels (SeqId = 11167-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Myotubularin-related protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000095 None Gadd-DA_mtmr1_protein_levels__seqid___11167-6__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 BMPR2 protein levels (SeqId = 4862-63) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BMPR2 protein levels (SeqId = 4862-63) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bone morphogenetic protein receptor type-2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000095 None Gadd-DA_bmpr2_protein_levels__seqid___4862-63__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.0331212 0.00848454 0.00009515324 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02734904 chr4:139145210 4 139145210 SLC7A11 Open sea 0.0322016 0.00825229 0.00009576979 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 BPI protein levels (SeqId = 4126-22) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BPI protein levels (SeqId = 4126-22) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Bactericidal permeability-increasing protein 774 1 Adults (18-65 years) Both European cg02102889 chr4:139164723 4 139164723 SLC7A11 Open sea 0.56 0.14 0.000096 None Gadd-DA_bpi_protein_levels__seqid___4126-22__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 IL31RA protein levels (SeqId = 8273-84) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL31RA protein levels (SeqId = 8273-84) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-31 receptor subunit alpha 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000096 None Gadd-DA_il31ra_protein_levels__seqid___8273-84__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KCNN1 protein levels (SeqId = 13539-131) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KCNN1 protein levels (SeqId = 13539-131) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Small conductance calcium-activated potassium channel protein 1 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000096 None Gadd-DA_kcnn1_protein_levels__seqid___13539-131__somascan_protein_measurement Battram T ARIES None 2020-08-20 Trunk total mass EFO_0004338 None None DNA methylation Trunk total mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 699 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.000017 0.0000043 0.000096 None Battram-T_trunk_total_mass Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.0300438 0.00770877 0.00009767999 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 IL27 protein levels (SeqId = 2829-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IL27 protein levels (SeqId = 2829-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Interleukin-27 subunit beta|Interleukin-27 subunit alpha 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.388 0.099 0.000098 None Gadd-DA_il27_protein_levels__seqid___2829-19__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 COL3A1 protein levels (SeqId = 18880-81) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 COL3A1 protein levels (SeqId = 18880-81) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen alpha-1(III) chain 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.099 0.000098 None Gadd-DA_col3a1_protein_levels__seqid___18880-81__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 POTEG protein levels (SeqId = 7960-53) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 POTEG protein levels (SeqId = 7960-53) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: POTE ankyrin domain family member G 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000098 None Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement Battram T ARIES None 2020-08-20 Android fat mass EFO_0005409 None None DNA methylation Android fat mass Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g Illumina HumanMethylation450 Whole blood DXA scan measurement 706 1 Adults Females European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.00011 0.000028 0.000098 None Battram-T_android_fat_mass Gadd DA Generation Scotland 35945220 31/07/2022 IGFBP2 protein levels (SeqId = 8469-41) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGFBP2 protein levels (SeqId = 8469-41) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like growth factor-binding protein 2 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea 0.39 0.099 0.000098 None Gadd-DA_igfbp2_protein_levels__seqid___8469-41__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KYNU protein levels (SeqId = 4559-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KYNU protein levels (SeqId = 4559-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Kynureninase 774 1 Adults (18-65 years) Both European cg06690548 chr4:139162808 4 139162808 SLC7A11 Open sea -0.39 0.1 0.000098 None Gadd-DA_kynu_protein_levels__seqid___4559-64__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07661704 chr4:139144433 4 139144433 SLC7A11 Open sea -0.0316756 0.0081313 0.00009842766 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24869834 chr4:139146513 4 139146513 SLC7A11 Open sea 0.0321334 0.00825231 0.0000990955 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1