author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	-0.0024	0.00028	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05810949	chr17:17740344	17	17740344	SREBF1	Island	-0.00038	0.000034	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.005	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0029	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.038	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.062	0.005	0	-	28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-3.431	0.337	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.003	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.013	0.0016	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15030378	chr17:17726965	17	17726965	SREBF1	Island	-0.0005	0.000054	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0026	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.012	0.001	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21652344	chr17:17740365	17	17740365	SREBF1	Island	-0.000082	0.0000095	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0064	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.018	0.0015	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0043	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.017	0.0016	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.34306	0.00404	7.9e-155	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.27655	0.00356	1.2e-147	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.23471	0.047298	2.265018e-147	None	39706196_Hannah-M.-Smith_bmi_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.26171	0.00357	6.1e-143	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	0.14554	0.00245	6.2e-126	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	0.61312	0.01035	9.9e-126	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.2316	0.0042	5e-120	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.28225	0.00527	8.7e-118	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.26608	0.054535	1.958871e-117	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.31923	0.00635	7.5e-113	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.06596	0.0476467	2.605117e-109	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.181515	0.00811941	6.938722e-109	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.177285	0.00812578	7.031695e-104	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.03279	0.0475389	2.847969e-103	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.174178	0.00813036	2.7795769999999996e-100	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.2415	0.00614	3.7e-94	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.12203	0.0550806	3.579438e-91	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.153057	0.00815929	1.328881e-77	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.00621	0.0550055	4.710761e-74	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.149423	0.00816388	5.221502e-74	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.148538	0.00816498	3.793836e-73	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.147695	0.00816602	2.484176e-72	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.147252	0.00816657	6.629666e-72	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-	-	2.66e-71	-	23526956_clear_cell_renal_carcinoma
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	5.8	0.331	9.1e-68	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.15878	0.00591	3.9000000000000005e-67	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.139051	0.00817636	3.0362000000000002e-64	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	0.04146	0.00167	4.3e-62	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.05887	0.00241	6e-61	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.145657	0.00891595	1.811702e-59	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.09503	0.00403	8.3e-59	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.14326	0.00889747	7.834636e-58	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.749214	0.0466214	1.029871e-57	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	3.26182	0.08622	8.42e-56	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.125031	0.00819178	3.394301e-52	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	3.40091	0.10012	5.48e-52	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.13273	0.00632	9.4e-52	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.122511	0.00819438	3.6150379999999997e-50	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.15	0.00993	2.8e-48	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	9.3e-47	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.116983	0.00819988	7.175967e-46	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.003	None	1.0000000000000001e-45	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.116595	0.00820026	1.414354e-45	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.115441	0.00820137	1.04411e-44	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.122379	0.00891178	1.194968e-42	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.112013	0.00820461	3.5333669999999997e-42	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.11169	0.00820491	6.065131e-42	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.111466	0.00820512	8.800561e-42	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg25999891	chr17:17724687	17	17724687	SREBF1	North shelf	2.29099	0.09094	9.759999999999999e-42	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.110492	0.00820602	4.424234e-41	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.110445	0.00820606	4.781601e-41	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.109727	0.00820672	1.555003e-40	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.108981	0.00820739	5.252965e-40	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.108714	0.00820764	8.118137e-40	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.707423	0.053825	2.817792e-39	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.226469	0.0174107	1.812296e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-1.84415	0.08097	2.0199999999999998e-38	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.106566	0.00820956	2.556418e-38	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.115489	0.00893436	5.154217e-38	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.104826	0.00821108	3.978304e-37	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	1.66783	0.07686	7.2600000000000005e-37	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.111397	0.00891932	1.294982e-35	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.158967	0.0128358	4.740709e-35	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.10147	0.00821396	6.968123e-35	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	2.03829	0.10079	1.22e-34	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.099073	0.00821595	2.5111190000000003e-33	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0982865	0.00821659	7.990965000000001e-33	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.106889	0.00895004	1.0038300000000001e-32	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0981168	0.00821673	1.024481e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.105653	0.00895782	5.807652e-32	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.105338	0.00893896	6.562814e-32	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.096087	0.00821837	1.936812e-31	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0955543	0.00821879	4.146365e-31	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.102357	0.00885803	9.438977e-31	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0948788	0.00821932	1.08194e-30	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 1	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based)	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.3	0.2	1.3000000000000001e-30	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	1.72e-30	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0943771	0.00821972	2.1961619999999998e-30	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.102794	0.00895784	2.3664159999999998e-30	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.121361	0.0106662	7.176304e-30	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0933453	0.00822052	9.306380000000001e-30	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.093231	0.00822061	1.091051e-29	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	2.05335	0.1205	1.8400000000000002e-29	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0926035	0.00822109	2.602601e-29	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-1.51108	0.09504	1.8e-27	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-	-	3.1700000000000002e-27	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0890422	0.00822378	3.235307e-27	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.24	0.022	3.7e-27	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0889224	0.00822386	3.792546e-27	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0101959	0.0009457	4.22e-27	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0884386	0.00822422	7.190743e-27	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0957866	0.00894537	1.17191e-26	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 2	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	3.2	0.3	1.5e-26	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0870037	0.00822526	4.697465e-26	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 2	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.16	0.11	5.3e-26	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0867452	0.00822545	6.565454999999999e-26	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.061	0.006	9.8e-26	-	28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0863259	0.00822575	1.127837e-25	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0861677	0.00822586	1.382244e-25	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.085956	0.00822601	1.8136140000000001e-25	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	22.7	2.2	3e-25	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0848243	0.00822681	7.662913e-25	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	2.76e-24	-	25935004_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.106832	0.0104939	2.9216500000000004e-24	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.89649718	0.0889	6.22e-24	-	25888029_ageing
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0827082	0.00822828	1.077416e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0900496	0.00896572	1.167153e-23	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	32.5	3	1.9e-23	-	28002404_body_mass_index_all_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0818331	0.00822888	3.1527810000000003e-23	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-3.5	0.351	3.6e-23	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0812294	0.00822929	6.569061000000001e-23	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.081091	0.00822938	7.767815000000001e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0884744	0.00899112	8.890943000000001e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0808752	0.00822952	1.007985e-22	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0808563	0.00822954	1.0313160000000001e-22	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0806896	0.00822965	1.260633e-22	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16657453	chr17:17735704	17	17735704	SREBF1	North shelf	0.02767	0.0025	2.3000000000000003e-22	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0801374	0.00823002	2.444746e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0800006	0.00823011	2.878651e-22	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0870434	0.00896228	3.121125e-22	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	4.82e-22	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0788585	0.00823086	1.114144e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0788464	0.00823087	1.130036e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0780473	0.00823139	2.8791069999999998e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0778451	0.00823152	3.642425e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25999891	chr17:17724687	17	17724687	SREBF1	North shelf	0.02946	0.00277	4.3e-21	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0771925	0.00823194	7.747711e-21	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.498904	0.0532162	7.748452e-21	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.324	0.0345685	7.92133e-21	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0839574	0.00897497	9.584188e-21	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0768781	0.00823214	1.112162e-20	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.076336	0.00823248	2.0666149999999998e-20	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0764259	0.00824301	2.085133e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0762455	0.00823254	2.290938e-20	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.100869	0.0109137	2.736042e-20	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.015	0.0016	2.85e-20	-	28194238_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-3.762	0.408	3.1e-20	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0866158	0.00942495	4.444845e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0811732	0.00883459	4.5251139999999995e-20	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0755309	0.00823299	5.1464189999999996e-20	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0821951	0.00897042	5.710814e-20	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0753918	0.00823307	6.018934999999999e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	28	3.07	7.1e-20	-	28002404_body_mass_index_european_ancestry_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.283251	0.0310625	8.371535e-20	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.074904	0.00823338	1.040316e-19	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0748992	0.00823338	1.045928e-19	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small HDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.7	0.19	2.5e-19	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_meta-analysis
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for lipid-lowering medication use	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, lipid-lowering medication use, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0147	0.0016	3e-19	-	28194238_triglycerides_discovery_and_replication_lipidlowering_medication_use_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0820714	0.00914083	3.0722939999999996e-19	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.496454	0.0555465	4.355575e-19	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.096	0.01078	4.6e-19	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.073381	0.00823431	5.613345e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0799333	0.00897299	5.78719e-19	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 1	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based)	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.8	0.09	6.2e-19	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14442061	chr17:17740468	17	17740468	SREBF1	Island	0.02298	0.00233	6.8e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0801817	0.00902657	7.263442999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0730179	0.00823453	8.34743e-19	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	17.16	1.94	9.1e-19	-	28002404_body_mass_index_european_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0727379	0.0082347	1.13211e-18	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0974256	0.0110364	1.188072e-18	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.119512	0.0135447	1.233055e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0724962	0.00823225	1.435468e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0016	None	4e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0957079	0.0110236	4.290485e-18	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0714591	0.00823546	4.485768e-18	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0818375	0.00943628	4.659778e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0950712	0.0109715	4.970624e-18	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.088822	0.0102756	5.983196e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0711564	0.00823564	6.192018e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.412301	0.0477654	6.538513e-18	None	39706196_Hannah-M.-Smith_glucose_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0023	None	6.8e-18	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0705751	0.00823598	1.145722e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.417895	0.048887	1.347924e-17	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.107123	0.0125784	1.803582e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.106891	0.0126029	2.4339210000000002e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.39522	0.0468	3.29e-17	-	25650246_gestational_age
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	3.63e-17	-	25935004_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0690597	0.00823686	5.56641e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.075137	0.00896525	5.724695e-17	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0860035	0.0102898	6.939445e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0688057	0.008237	7.231104000000001e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0687346	0.00823704	7.779245e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0915463	0.010993	8.964026e-17	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0684075	0.00823723	1.087739e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.05468	0.00601	1.1e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0823071	0.00994073	1.339809e-16	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0902646	0.0109542	1.86387e-16	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes and CD4+ T cells	Regression coefficient per 1 SD of waist circumference	3088	2	53.9	Both	European,African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	2.37e-16	-	25935004_waist_circumference_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0894995	0.0109142	2.595163e-16	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14442061	chr17:17740468	17	17740468	SREBF1	Island	0.0002	None	3.1e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.039	0.005	3.2e-16	-	28173150_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0672874	0.00823786	3.38755e-16	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0671682	0.00823793	3.818706e-16	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0671123	0.00823796	4.038891e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0670093	0.00823801	4.478417e-16	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0669943	0.00823802	4.546056e-16	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0669809	0.00823803	4.607621e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0669736	0.00823803	4.641427e-16	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.0667159	0.00823818	6.005026e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0665782	0.00823825	6.888595e-16	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.00117678	0.00014416	9.14e-16	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0864662	0.0107566	9.791293e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0661625	0.00823848	0.000000000000001040655	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0661288	0.0082385	0.000000000000001075929	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0720404	0.00898167	0.000000000000001129318	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium HDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.8	0.22	0.0000000000000013	None	33413638_Gomez-Alonso-MDC_m-hdl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0659087	0.00823862	0.000000000000001337055	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0658325	0.00823866	0.000000000000001441295	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0653707	0.00823891	0.000000000000002267509	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.072	0.262	0.0000000000000024	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.421925	0.053377	0.000000000000002848336	None	39706196_Hannah-M.-Smith_body_fat_discovery
Dhana K	Rotterdam study	29762635	2018-05-14	Waist Circumference	EFO_0004342	Discovery	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0005	0.000063	0.0000000000000029	None	29762635_Dhana-K_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0699941	0.00886212	0.000000000000003031558	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0710277	0.00901325	0.000000000000003492797	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0648974	0.00823917	0.000000000000003596398	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0103942	0.0013225	0.00000000000000386	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0646365	0.00823931	0.000000000000004630774	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0644502	0.00823941	0.00000000000000554387	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0643116	0.00823948	0.000000000000006335765	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.108018	0.0138405	0.000000000000006377312	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Dhana K	Rotterdam study	29762635	2018-05-14	Body mass index	EFO_0004340	Discovery	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0013	0.00017	0.0000000000000066	None	29762635_Dhana-K_body_mass_index_discovery
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0319	0.00405	0.00000000000000687	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0641544	0.00823956	0.000000000000007369254	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0698388	0.00897921	0.00000000000000786721	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0640858	0.0082396	0.000000000000007870762	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0089	0.0012	0.00000000000001	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0638239	0.00823974	0.00000000000001011274	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0638185	0.00823974	0.00000000000001016464	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0636544	0.00823983	0.00000000000001188727	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.063425	0.00823995	0.00000000000001478637	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.134887	0.0175853	0.00000000000001822146	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.068885	0.00898303	0.00000000000001851429	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0102837	0.001345	0.0000000000000207	-	28213390_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0630492	0.00824014	0.00000000000002110435	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05666074	chr17:17727281	17	17727281	SREBF1	Island	0.00031	0.000041	0.000000000000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05666074	chr17:17727281	17	17727281	SREBF1	Island	0.00774	0.00094	0.000000000000025	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	60.27	6.92	0.000000000000025	-	28002404_body_mass_index_south_asian_ancestry_discovery
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0101074	0.0013269	0.0000000000000259	-	28213390_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0628178	0.00824026	0.00000000000002624506	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0627312	0.00824031	0.00000000000002847092	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.042	0.00546	0.00000000000003	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0624984	0.00824043	0.00000000000003541337	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.082156	0.0108548	0.00000000000003996783	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0623568	0.0082405	0.00000000000004042742	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0623062	0.00824053	0.00000000000004238176	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0622031	0.00824058	0.00000000000004665887	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.059	0.008	0.0000000000000554	-	25583993_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.114031	0.0151763	0.00000000000006078131	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0673272	0.00896791	0.00000000000006369949	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.082457	0.0110158	0.00000000000007541269	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0616665	0.00824086	0.00000000000007675308	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0616143	0.00824088	0.00000000000008054361	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.081947	0.011025	0.0000000000001121615	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0683313	0.00919324	0.0000000000001122145	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.17752	0.0239	0.000000000000115	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0796102	0.010721	0.0000000000001184155	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00341606	chr17:17740405	17	17740405	SREBF1	Island	0.0002	None	0.00000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0609496	0.00824122	0.0000000000001482818	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0650747	0.00881895	0.0000000000001680768	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0608085	0.00824129	0.0000000000001686459	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.060714	0.00824134	0.0000000000001838071	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0007762	0.00010427	0.000000000000203	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0660526	0.00898814	0.0000000000002104576	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0614641	0.00836985	0.0000000000002189953	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0604512	0.00824147	0.0000000000002333378	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0603128	0.00824154	0.0000000000002644561	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.06387	0.00813	0.00000000000027	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0811423	0.0110928	0.0000000000002710526	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0655885	0.00897176	0.0000000000002798011	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0647023	0.00889321	0.000000000000362719	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	-0.0599376	0.00824173	0.0000000000003708669	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0599208	0.00824174	0.0000000000003764925	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.386701	0.0532285	0.0000000000003891367	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.110328	0.0151986	0.0000000000004093378	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.534638	0.0737229	0.0000000000004280707	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0596284	0.00824188	0.000000000000489305	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.003	0.000415	0.000000000000504	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0594328	0.00824198	0.0000000000005825985	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0597197	0.00828197	0.0000000000005834134	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.101925	0.0141463	0.0000000000006084242	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.059367	0.00824201	0.0000000000006177903	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06287342	chr17:17721774	17	17721774	SREBF1	Open sea	-0.0593343	0.00824202	0.0000000000006360501	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.382	0.331	0.00000000000065	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0591773	0.0082421	0.0000000000007312521	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for waist circumference	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, waist circumference, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0124	0.0017	0.00000000000084	-	28194238_triglycerides_discovery_and_replication_waist_circumference_adjusted
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23159296	chr17:17740009	17	17740009	SREBF1	Island	-0.00005	0.000007	0.00000000000088	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0988238	0.0138214	0.0000000000009083298	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Discovery	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	1366	2	74.3	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.192	0.027	0.000000000000956	-	26119815_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0782699	0.0109614	0.0000000000009736845	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0137	0.0019	0.0000000000011	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0586393	0.00824236	0.000000000001176208	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0786367	0.0110592	0.000000000001209605	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	-0.087117	0.0122531	0.000000000001216051	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.126353	0.0177791	0.000000000001241887	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0584345	0.00824246	0.000000000001407962	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	63	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002176	3.08e-05	0.00000000000166	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0633992	0.00897188	0.000000000001661384	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0633872	0.0089732	0.000000000001689877	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0634757	0.00898946	0.000000000001725806	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0765307	0.0108391	0.000000000001732338	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0581623	0.00824259	0.000000000001786494	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Replication	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	752	1	45.5	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.253	0.035	0.00000000000179	-	26119815_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.058128	0.00824261	0.000000000001840711	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0660091	0.00936204	0.000000000001859483	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0578379	0.00824275	0.00000000000236928	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.066845	0.00956109	0.000000000002840111	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0758425	0.0108519	0.000000000002890961	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0574686	0.00824293	0.000000000003261135	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0583204	0.00836586	0.000000000003275834	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0682648	0.00979633	0.000000000003342235	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Waist Circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.00115	0.0000000000035	None	29762635_Dhana-K_waist_circumference_replication
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.0012	0.00000000000352	-	25935004_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0573598	0.00824298	0.000000000003581656	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0096	0.0014	0.00000000000362	-	28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0572781	0.00824302	0.000000000003842473	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.0570783	0.00824311	0.000000000004561321	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0629788	0.00910108	0.000000000004706177	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0570065	0.00824314	0.000000000004850602	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0567975	0.00824324	0.000000000005798994	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0567301	0.00824327	0.000000000006141569	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.08042	0.0117	0.00000000000615	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0565524	0.00824336	0.000000000007143529	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0565108	0.00824338	0.000000000007400676	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M32388_dodecanedioate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32388_dodecanedioate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.76	0.09	0.0000000000077	None	24014485_Petersen-A-K_m32388_dodecanedioate_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0563918	0.00824343	0.000000000008186064	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.23719	0.0346887	0.000000000008318001	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0733488	0.0107376	0.00000000000876437	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.26756	0.0392091	0.000000000009152157	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06261007	chr17:17740275	17	17740275	SREBF1	Island	-0.000046	0.0000068	0.00000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for other lipids	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, other lipids, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0138	0.002	0.00000000001	-	28194238_triglycerides_discovery_and_replication_other_lipids_adjusted
Petersen A-K	KORA F4	24014485	2013-09-06	M35718_dihomo-linolenate_20:3n3_or_n6	EFO_0004727, EFO_0004725	no snps model	Table S2	M35718_dihomo-linolenate_20:3n3_or_n6	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.88	0.135	0.00000000001	None	24014485_Petersen-A-K_m35718_dihomo-linolenate_20_3n3_or_n6_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0561494	0.00824355	0.0000000000100473	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0561277	0.00824356	0.00000000001023289	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0560433	0.00824359	0.00000000001098644	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	0.0008	None	0.000000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg06287342	chr17:17721774	17	17721774	SREBF1	Open sea	0.044	0.00576	0.000000000011	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0577476	0.00849935	0.00000000001129976	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0558975	0.00824366	0.00000000001241933	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0568951	0.00839165	0.00000000001247972	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0893946	0.0132029	0.00000000001329398	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.18059	0.0267	0.0000000000138	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0567435	0.00838867	0.0000000000139025	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0556633	0.00824377	0.00000000001511223	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0555965	0.0082438	0.00000000001597997	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14442061	chr17:17740468	17	17740468	SREBF1	Island	0.00014	0.00002	0.000000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Petersen A-K	KORA F4	24014485	2013-09-06	M32388_dodecanedioate	EFO_0004727, EFO_0004725	no snps model	Table S2	M32388_dodecanedioate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.75	0.088	0.000000000016	None	24014485_Petersen-A-K_m32388_dodecanedioate_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0554968	0.00824385	0.00000000001736784	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0553846	0.0082439	0.0000000000190682	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0553656	0.00824391	0.00000000001937269	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0715378	0.0106819	0.00000000002203774	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0615617	0.00920232	0.00000000002315746	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.328157	0.0490787	0.00000000002354339	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.054964	0.00824409	0.00000000002702596	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.00063	0.000093	0.000000000029	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0548517	0.00824414	0.00000000002965241	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	-0.293501	0.0442046	0.00000000003233922	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	760	1	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0172	0.0026	0.0000000000327	-	28194238_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0548454	0.00827576	0.00000000003539584	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.060042	0.00906027	0.00000000003546285	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0723846	0.0109245	0.0000000000357168	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.06002	0.00906372	0.00000000003667037	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg25999891	chr17:17724687	17	17724687	SREBF1	North shelf	-0.09642	0.0146	0.0000000000382	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.358619	0.0542331	0.0000000000388254	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.228577	0.0345855	0.00000000003981083	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0919629	0.0139234	0.000000000041146	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0602292	0.00913925	0.0000000000454346	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0542034	0.00824443	0.00000000005045136	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.00098	0.00015	0.000000000051	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.054098	0.00824448	0.00000000005497433	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0540622	0.0082445	0.00000000005659838	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0575294	0.00877723	0.00000000005773286	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.054018	0.00824452	0.00000000005866833	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0628492	0.00960466	0.00000000006204059	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0538845	0.00824458	0.0000000000653787	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0545866	0.00836454	0.00000000006978573	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0538	0.00824461	0.00000000007001184	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.483899	0.0742225	0.00000000007246228	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0537355	0.00824464	0.00000000007376012	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0536773	0.00824467	0.00000000007731275	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M35186_1-arachidonoylglycerophosphoethanolamine*	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M35186_1-arachidonoylglycerophosphoethanolamine*	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	16918.43	0.65	0.000000000078	None	24014485_Petersen-A-K_m35186_1-arachidonoylglycerophosphoethanolamine__snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0536127	0.0082447	0.00000000008144845	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.112943	0.0174016	0.00000000008837453	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.069741	0.0107507	0.00000000009029325	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-1.679763	0.2595	0.0000000000964	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0533016	0.00824483	0.0000000001046096	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000000011	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.053147	0.0082449	0.0000000001183917	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.463819	0.0720599	0.000000000125251	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0903024	0.0140314	0.0000000001267077	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.375147	0.0583962	0.0000000001360595	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0574193	0.00893955	0.0000000001376705	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	-0.0528901	0.00824502	0.0000000001453328	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0527627	0.00824507	0.0000000001608314	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.299159	0.0467578	0.00000000016119	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0527371	0.00824508	0.0000000001641255	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000000017	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Justice AE	ARIC study	32901515	09-09-2020	waist circumference-to-hip ratio	None	discovery	Table 1	waist circumference-to-hip ratio	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	cm	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	0.5	0.078	0.00000000017	None	32901515_Justice-AE_waist_circumference-to-hip_ratio_discovery
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.07	0.33	0.00000000019	4740	31197173_Liu-J_fasting_insulin_base
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.87	0.29	0.00000000019	4808	31197173_Liu-J_fasting_glucose_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0522557	0.00824529	0.0000000002401229	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0522474	0.00824529	0.000000000241706	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0603047	0.00951814	0.0000000002430629	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0522217	0.00824531	0.0000000002466282	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	-	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.056	0.0089	0.00000000025	-	27019061_fasting_glucose
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-0.00067	0.00011	0.00000000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.288707	0.0457366	0.0000000002811018	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.080869	0.0128233	0.0000000002937372	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Meta-analysis	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	3805	4	53	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0677	0.0107	0.0000000003	-	26095709_type_ii_diabetes_metaanalysis
Petersen A-K	KORA F4	24014485	2013-09-06	M35186_1-arachidonoylglycerophosphoethanolamine*	EFO_0004727, EFO_0004725	no snps model	Table S2	M35186_1-arachidonoylglycerophosphoethanolamine*	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	11142.86	0.64	0.0000000003	None	24014485_Petersen-A-K_m35186_1-arachidonoylglycerophosphoethanolamine__no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0564915	0.00896363	0.0000000003016415	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0519569	0.00824542	0.000000000303576	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0575403	0.00913304	0.0000000003056872	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0519225	0.00824543	0.0000000003118588	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	725	1	60	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0135	0.0021	0.00000000034	-	28194238_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0517591	0.0082455	0.0000000003542998	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0517591	0.0082455	0.0000000003543073	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.294247	0.0468953	0.0000000003589643	None	39706196_Hannah-M.-Smith_bmi_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.15	0.0236	0.00000000036	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0517184	0.00824552	0.0000000003657181	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-	-	0.000000000375	-	26857698_primary_sjogrens_syndrome_whole_blood
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	3.9	0.622	0.0000000004	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0524898	0.00839299	0.0000000004111587	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0524001	0.00840382	0.0000000004633716	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0662585	0.0106475	0.0000000005013232	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M00054_tryptophan	EFO_0004727, EFO_0004725	no snps model	Table S2	M00054_tryptophan	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.46	0.026	0.00000000051	None	24014485_Petersen-A-K_m00054_tryptophan_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0512883	0.0082457	0.0000000005106493	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0574106	0.00924978	0.000000000555667	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0682996	0.0110213	0.0000000005906099	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.44	None	0.0000000006	None	31506343_Cardona-A_type_ii_diabetes_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0510716	0.0082458	0.0000000006035169	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.051058	0.0082458	0.0000000006098769	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0510327	0.00824581	0.0000000006218838	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M15964_arabitol	EFO_0004727, EFO_0004725	no snps model	Table S2	M15964_arabitol	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	13.5	0.187	0.00000000064	None	24014485_Petersen-A-K_m15964_arabitol_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0555482	0.00898758	0.0000000006557156	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0545231	0.00884006	0.0000000007109913	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0562687	0.00912624	0.0000000007205872	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0656425	0.0106496	0.0000000007285572	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.05484	0.00891891	0.0000000008013011	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	-0.0506884	0.00824596	0.0000000008097335	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.104563	0.0170423	0.0000000008709614	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.481771	0.0785443	0.0000000008759899	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0505378	0.00824602	0.0000000009084155	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0669114	0.0109305	0.0000000009503649	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Yang BZ	-	23332324	2013-02-01	Child abuse	-	-	Appendix B	DNA methylation	Child abuse	Sex, age and ethnicity	Beta values	-	Illumina HumanMethylation450	Saliva	-	192	1	10	Both	European,African,Admixed,Other	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-	-	0.000000001	-	23332324_child_abuse
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0502949	0.00824612	0.000000001092652	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.01838	0.00287	0.0000000011	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0502068	0.00824616	0.000000001168101	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.237012	0.0389449	0.000000001183408	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.357699	0.058782	0.000000001188128	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0655005	0.01078	0.000000001261989	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.439442	0.0724199	0.000000001320903	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0015	0.00025	0.0000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0498993	0.00824629	0.000000001473441	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0507603	0.00839835	0.000000001539072	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0497872	0.00824633	0.000000001602959	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0497861	0.00824633	0.00000000160436	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0496655	0.00824638	0.000000001756214	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0496472	0.00824639	0.000000001780519	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0496382	0.00824639	0.000000001792609	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0792514	0.0131663	0.000000001793976	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0495744	0.00824642	0.000000001880303	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.049569	0.00824642	0.000000001887898	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0097553	0.0016269	0.00000000202	-	28213390_serum_triglycerides_discovery
Cardona A	LOLIPOP	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Indians	Table 3	Type II diabetes	DNA methylation	Cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2664	1	Adults	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.336	None	0.0000000022	None	31506343_Cardona-A_type_ii_diabetes_replication_in_indians
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0549982	0.00920536	0.000000002360189	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.190713	0.0319417	0.000000002409122	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0747324	0.0125251	0.000000002478405	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0534791	0.0089693	0.000000002541658	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0490703	0.00824663	0.000000002736716	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Lothian Birth Cohort 1936	Table S1	DNA methylation	Body mass index	Age, sex and cell counts	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	920	1	70	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0063	0.00105	0.00000000276	-	28095459_body_mass_index_lothian_birth_cohort_1936
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0490537	0.00824663	0.000000002770434	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0490283	0.00824664	0.000000002823191	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0558857	0.009403	0.00000000285518	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0489701	0.00824667	0.000000002947248	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0489495	0.00824667	0.000000002992558	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0489281	0.00824668	0.000000003040265	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.048921	0.00824669	0.000000003056274	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.054479	0.0091837	0.000000003057358	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0824462	0.0139003	0.000000003074109	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.30999	0.0523644	0.000000003280033	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0487569	0.00824675	0.000000003449584	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Alvizi L	-	28550290	2017-05-26	Non-syndromic cleft lip and palate	EFO_0003959, HP_0000175	Discovery	Table S1	Non-syndromic cleft lip and palate	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	-	126	1	6	Both	European,Other	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-	-	0.00000000356	-	28550290_nonsyndromic_cleft_lip_and_palate_discovery
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.047	0.00722	0.0000000038	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0494528	0.00839603	0.000000003945841	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0983814	0.0167082	0.000000003989823	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0643083	0.010922	0.000000003995469	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.102756	0.0174658	0.000000004110508	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002133	3.63e-05	0.00000000419	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0028	0.00043	0.0000000042	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0483733	0.00824691	0.000000004570584	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0482934	0.00824694	0.000000004845371	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0491646	0.00839964	0.00000000492562	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.048257	0.00824695	0.000000004975541	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0482425	0.00824696	0.000000005028679	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0797408	0.0136498	0.000000005269897	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0645308	0.0110562	0.000000005439344	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.065	0.011	0.0000000056	-	28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0524374	0.00899737	0.000000005724807	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0480127	0.00824705	0.000000005943406	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0479492	0.00824707	0.000000006223495	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0641635	0.0110362	0.000000006230221	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.051492	0.00885713	0.000000006240987	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0478734	0.0082471	0.000000006574591	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0478323	0.00824712	0.000000006773041	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0478102	0.00824713	0.000000006881886	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.047756	0.00824715	0.000000007156902	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0477206	0.00824716	0.000000007342256	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0477071	0.00824717	0.000000007414112	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0757915	0.013108	0.000000007528384	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0476707	0.00824718	0.000000007611314	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0476278	0.0082472	0.000000007849689	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0801711	0.0138887	0.000000007972344	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3747966 (gene symbol: SREBF1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3747966 (gene symbol: SREBF1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	None	None	0.0000000083	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3747966__gene_symbol__srebf1__meta-analysis
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Discovery	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	2664	1	50	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.05826891	0.0101	0.0000000084	-	26095709_type_ii_diabetes_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0551099	0.00956531	0.000000008507665	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.088012	0.0152873	0.000000008723522	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0474413	0.00824727	0.000000008976143	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0562394	0.00978485	0.00000000923211	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0068	0.0012	0.00000000958	-	25935004_body_mass_index_discovery
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0068	0.00119	0.0000000096	None	29762635_Dhana-K_body_mass_index_replication
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	random effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.86	0.15	0.0000000098	None	33646943_Hannon-E_schizophrenia_random_effects_meta-analysis
Hannon E	None	33646943	2021-02-26	schizophrenia	EFO_0000692	fixed effects meta-analysis	Supplementary Table 3	DNA methylation	schizophrenia	Age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3264	7	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.86	0.15	0.0000000098	None	33646943_Hannon-E_schizophrenia_fixed_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0806294	0.0140583	0.000000009922036	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08452483	chr17:17724058	17	17724058	SREBF1	North shelf	0.244868	0.0427412	0.00000001025623	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.054972	0.00960046	0.00000001048563	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0471917	0.00824737	0.00000001073184	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0528301	0.00923551	0.00000001084012	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0560401	0.00979898	0.00000001092598	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	0.225003	0.039413	0.00000001155033	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.177035	0.0310268	0.00000001176314	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0470142	0.00824744	0.00000001217886	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.00046	0.000079	0.000000013	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.376328	0.0663147	0.00000001410072	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0506507	0.00893482	0.00000001464175	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.295418	0.0521652	0.00000001508817	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0862147	0.0152275	0.00000001526364	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0466295	0.00824759	0.00000001599435	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery and replication	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	979	1	48.3	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	20.64	3.63	0.0000000168	-	27777315_postprandial_lipemia_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0471897	0.00836319	0.00000001706563	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0472967	0.00839067	0.00000001764123	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.329513	0.0585775	0.00000001881029	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	-0.00026193	4.63e-05	0.0000000194	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0728746	0.0129697	0.00000001957354	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0462072	0.00824775	0.00000002152062	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.036	0.00592	0.000000022	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0461492	0.00824777	0.00000002241154	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0607069	0.0108692	0.00000002375343	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.402611	0.0721191	0.00000002403456	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0049	0.00088	0.000000025	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0459712	0.00824784	0.00000002537389	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0019	None	0.000000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0533765	0.00958484	0.00000002609391	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0511938	0.00919348	0.00000002614701	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07097265	chr17:17727093	17	17727093	SREBF1	Island	0.00038	None	0.000000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0526768	0.0094745	0.00000002747177	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0458499	0.00824789	0.00000002760755	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0458448	0.00824789	0.00000002770624	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.0719494	0.0129516	0.00000002820442	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0458113	0.0082479	0.00000002835704	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0999773	0.0180088	0.00000002880098	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0457378	0.00824793	0.00000002984025	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0523053	0.00943975	0.00000003059993	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0456741	0.00824795	0.00000003118729	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0455665	0.008248	0.00000003359491	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0093458	0.0016926	0.0000000336	-	28213390_serum_triglycerides_discovery_adjusted_for_bmi
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.24974	0.0453099	0.00000003602311	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	-0.0454377	0.00824804	0.00000003671596	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	1.5	0.278	0.000000037	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Song N	St Jude Lifetime Cohort	33823916	2021-04-06	Cancer treatment: chest-RT	None	None	Table S2	DNA methylation	Cancer treatment: chest-RT	sex, age, other cancer treatment exposures, cell composition (reference based), ancestry (genomic PCs), batch effects	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2052	1	Children	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.054	0.008	0.000000037	None	33823916_Song-N_cancer_treatment__chest-rt
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0454201	0.00824805	0.0000000371634	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0452223	0.00824812	0.00000004257053	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0451984	0.00824813	0.00000004327316	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	0.0449754	0.00824822	0.00000005040151	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	0.01192	0.0022	0.0000000508	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0723275	0.0132701	0.00000005107036	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.052023	0.00954963	0.00000005186318	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0752846	0.0138269	0.00000005269389	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0448877	0.00824825	0.00000005350533	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Cardona A	FHS	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Europeans	Table 3	DNA methylation	Type II diabetes	Age, sex, cell composition (reference based), batch effects, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2607	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0086	0.0016	0.000000054	None	31506343_Cardona-A_type_ii_diabetes_replication_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0508284	0.00934664	0.0000000546982	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0515603	0.00949134	0.00000005650208	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Discovery	Table 2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	731	1	59.6	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.009	0.001	0.000000057	-	28624579_gammaglutamyl_transferase_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0447921	0.00824828	0.00000005709945	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0447878	0.00824829	0.0000000572662	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0447821	0.00824829	0.00000005748879	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.303009	0.0558833	0.00000005962558	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0496372	0.00915457	0.00000005982667	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	653	1	48	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	25.41	4.64	0.000000061	-	27777315_postprandial_lipemia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.076345	0.0140968	0.0000000619845	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0446597	0.00824833	0.00000006246538	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0587649	0.0108549	0.00000006272094	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0522036	0.00965234	0.00000006459348	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0484555	0.00896615	0.00000006608861	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.175131	0.0324201	0.00000006675125	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0445374	0.00824838	0.00000006785455	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0456406	0.00845309	0.00000006795199	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.04453	0.00824838	0.00000006819619	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0444807	0.0082484	0.00000007050075	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.044472	0.0082484	0.00000007091826	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.044469	0.0082484	0.00000007106237	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.044393	0.00824843	0.00000007479773	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0443833	0.00824844	0.00000007529018	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0442914	0.00824847	0.0000000800926	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0442853	0.00824847	0.00000008041803	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0884448	0.0164758	0.00000008075534	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0709777	0.0132333	0.00000008283895	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05666074	chr17:17727281	17	17727281	SREBF1	Island	0.00027	None	0.000000085	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0523907	0.00978859	0.00000008818809	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0448088	0.00838211	0.00000009138073	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0543304	0.0101658	0.00000009204903	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0478644	0.00895797	0.00000009267577	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0440044	0.00824857	0.00000009707904	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0439912	0.00824858	0.00000009793924	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0439862	0.00824858	0.00000009826268	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg14442061	chr17:17740468	17	17740468	SREBF1	Island	0.00709	0.0013	0.000000101	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0508841	0.00956165	0.0000001043227	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0807351	0.0151735	0.0000001048315	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.382701	0.0719407	0.0000001051769	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.241591	0.0454164	0.0000001053683	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0438635	0.00824862	0.0000001066407	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.13	0.0237	0.00000011	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	0.0025	None	0.00000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	0.0438091	0.00824864	0.0000001105745	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.249483	0.0470179	0.0000001133603	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.0437667	0.00824866	0.0000001137411	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0818995	0.0154368	0.0000001140278	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0591998	0.0111673	0.0000001167354	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.8	0.35	0.00000013	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0474737	0.00899208	0.000000131384	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	0.0434493	0.00824877	0.0000001403561	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0551617	0.0104735	0.0000001407892	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0739879	0.0140694	0.0000001470611	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0579798	0.0110332	0.0000001500724	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0433241	0.00824882	0.0000001524318	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0432983	0.00824883	0.0000001550376	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.174958	0.033335	0.0000001551646	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0492853	0.00939127	0.0000001559083	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00341606	chr17:17740405	17	17740405	SREBF1	Island	0.00013	0.000025	0.00000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0432457	0.00824885	0.0000001604958	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0431901	0.00824887	0.0000001664707	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0503132	0.00961255	0.0000001680678	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0571777	0.010931	0.0000001711232	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0431258	0.00824889	0.0000001736379	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0547885	0.0104806	0.0000001740697	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0430743	0.00824891	0.000000179601	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0571973	0.0109592	0.000000182217	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0430505	0.00824892	0.0000001824209	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.166513	0.0319246	0.0000001851015	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0430224	0.00824893	0.0000001857979	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0553507	0.0106194	0.0000001891362	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0429871	0.00824894	0.0000001901372	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0437621	0.00839854	0.0000001907097	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0733016	0.0140803	0.00000019559	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0477369	0.00917458	0.0000001985603	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0653574	0.012562	0.0000001989846	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0429005	0.00824897	0.0000002011959	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0544011	0.0104763	0.0000002099404	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0428244	0.008249	0.0000002114287	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0428146	0.008249	0.000000212788	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0477092	0.00920706	0.0000002226694	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0427068	0.00824904	0.0000002282306	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	7.55e-05	1.46e-05	0.000000234	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0679539	0.0131694	0.0000002501844	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0425622	0.00824909	0.0000002506726	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.0424845	0.00824912	0.0000002635995	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.047376	0.00920435	0.0000002679192	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000027	None	30796027_Jiantao-Ma_hepatic_fat_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12079271	chr17:17740387	17	17740387	SREBF1	Island	-0.000086	0.000017	0.00000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0794674	0.0154509	0.0000002735557	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0460697	0.00895857	0.0000002745573	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0116162	0.0022626	0.000000284	-	28213390_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0423154	0.00824918	0.0000002939779	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.379427	0.0739874	0.0000002955858	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0422445	0.0082492	0.0000003076936	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0422415	0.0082492	0.0000003082859	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.042226	0.00824921	0.000000311381	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0422048	0.00824921	0.0000003156486	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0421998	0.00824922	0.0000003166647	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0421919	0.00824922	0.000000318287	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0478861	0.009366	0.0000003214935	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0677202	0.0132603	0.0000003314119	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0421112	0.00824925	0.0000003351972	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0612982	0.0120169	0.0000003421	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-	-	0.000000351	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0420109	0.00824928	0.0000003574148	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0419882	0.00824929	0.0000003626615	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0489945	0.0096378	0.000000374963	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0432369	0.00850896	0.0000003793971	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0419162	0.00824932	0.00000037973	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0670473	0.0131956	0.0000003799943	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0427079	0.00840562	0.0000003803335	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.238043	0.0468771	0.0000003853693	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.025	0.00489	0.00000039	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0418541	0.00824934	0.0000003950658	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.047597	0.00938566	0.0000004000424	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0418225	0.00824935	0.0000004031055	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.041816	0.00824935	0.0000004047721	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	0.229568	0.0453315	0.0000004140788	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0417774	0.00824936	0.0000004148292	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.25043	0.0495291	0.0000004320412	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.0416877	0.00824939	0.0000004391709	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0484603	0.00959399	0.000000444527	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0416401	0.00824941	0.0000004526592	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0483278	0.00957934	0.0000004589403	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.047	0.0093	0.00000046	None	Battram-T_phospholipids_to_total_lipids_ratio_in_large_hdl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.00069	0.00014	0.00000046	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0698846	0.013863	0.0000004684495	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0415784	0.00824943	0.0000004706949	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0604316	0.0119902	0.0000004708414	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0420283	0.0083396	0.0000004720498	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0415593	0.00824944	0.0000004764126	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0468338	0.00930245	0.0000004846244	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0551378	0.0109575	0.000000491228	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0414621	0.00824947	0.0000005066272	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0666883	0.0132761	0.0000005142099	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0728426	0.0145112	0.000000523449	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0414073	0.00824949	0.0000005244544	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0420774	0.00838676	0.000000530646	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0421424	0.0084019	0.0000005342793	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08452483	chr17:17724058	17	17724058	SREBF1	North shelf	0.259761	0.0518278	0.0000005437312	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0413074	0.00824952	0.0000005585492	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0468866	0.0093712	0.0000005702047	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06287342	chr17:17721774	17	17721774	SREBF1	Open sea	-0.0412211	0.00824955	0.0000005896896	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.166722	0.0334139	0.0000006108773	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0523285	0.0104875	0.0000006119973	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00341606	chr17:17740405	17	17740405	SREBF1	Island	0.00059	None	0.00000063	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0410863	0.0082496	0.000000641757	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg20155005	chr17:17722624	17	17722624	SREBF1	Open sea	0.214157	0.0430116	0.0000006450863	None	39706196_Hannah-M.-Smith_bmi_discovery
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000066	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0422732	0.00849889	0.0000006633975	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0410269	0.00824962	0.0000006660584	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0611393	0.0123162	0.0000006978835	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21020221	chr17:17721180	17	17721180	SREBF1	Open sea	0.0409443	0.00824965	0.0000007013398	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0409355	0.00824965	0.0000007052162	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.279936	0.0564529	0.0000007162199	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.283947	0.0573554	0.0000007462499	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0407726	0.00824971	0.0000007805551	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0696314	0.0140913	0.0000007840707	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0407165	0.00824972	0.0000008082282	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0415908	0.00843036	0.0000008167116	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0406911	0.00824973	0.0000008210977	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0413954	0.00839763	0.0000008337597	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.144	0.029	0.00000084	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0406296	0.00824975	0.0000008530064	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0442219	0.00898609	0.0000008697158	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0405643	0.00824978	0.0000008882116	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0405564	0.00824978	0.0000008925701	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.040548	0.00824978	0.0000008972589	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0404952	0.0082498	0.0000009270194	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0404832	0.0082498	0.000000933919	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.00066065	0.00013391	0.000000937	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.0404667	0.00824981	0.0000009434713	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.045251	0.00923748	0.0000009753922	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0404125	0.00824983	0.0000009755498	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.040345	0.00824985	0.000001017009	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0437554	0.00896427	0.000001066112	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0477862	0.00979912	0.000001090725	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.040203	0.0082499	0.000001109813	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0401811	0.0082499	0.000001124786	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.040163	0.00824991	0.000001137366	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.040141	0.00824992	0.000001152785	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0530369	0.0109048	0.000001164569	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.163172	0.0335646	0.000001175094	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0683505	0.0140613	0.000001180672	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0406203	0.00835995	0.00000119248	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0400686	0.00824994	0.000001205084	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0407558	0.00839675	0.00000122392	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	-0.0485022	0.00999804	0.000001239962	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0399755	0.00824997	0.000001275651	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0411817	0.00849965	0.000001278403	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.039966	0.00824997	0.000001283041	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Juvinao-Quintero DL	ALSPAC, LBC1936, RSIII-1, RS-Bios	33622391	2021-02-23	Type 2 diabetes	EFO_0001360	meta-analysis	Table 2	DNA methylation	Type 2 diabetes	age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3428	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.00159	0.0000013	None	33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.039936	0.00824998	0.000001306797	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.184697	0.0381607	0.00000130912	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0534974	0.0110553	0.000001317679	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0752544	0.015556	0.000001327197	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0398879	0.00825	0.000001345656	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0507834	0.010509	0.000001362756	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0398594	0.00825001	0.000001369197	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0398418	0.00825002	0.00000138395	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.00026	0.000053	0.0000014	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.039804	0.00825003	0.000001416163	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0397766	0.00825004	0.000001439949	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0397537	0.00825004	0.000001460137	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.0064	0.0013	0.0000015	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0669168	0.0139072	0.000001511835	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0396771	0.00825007	0.000001529604	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.039653	0.00825008	0.000001552156	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0460691	0.00958501	0.000001552191	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0526092	0.0109581	0.000001594885	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0859551	0.01791	0.000001608078	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0395042	0.00825013	0.000001698266	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SHBG protein levels (SeqId = 4929-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHBG protein levels (SeqId = 4929-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sex hormone-binding globulin	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-1.19	0.249	0.0000017	None	Gadd-DA_shbg_protein_levels__seqid___4929-55__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0038	0.0008	0.0000017	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOB protein levels (SeqId = 18185-118)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOB protein levels (SeqId = 18185-118)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase B	774	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	1.09	0.227	0.0000017	None	Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0394662	0.00825014	0.000001737754	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0394503	0.00825014	0.000001754428	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0647937	0.0135532	0.000001763926	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0468135	0.00981317	0.000001855548	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	-0.0393394	0.00825018	0.000001875613	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.24	0.0503	0.0000019	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.00030102	6.29e-05	0.00000191	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0393071	0.00825019	0.000001912401	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0392756	0.0082502	0.00000194901	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	Adjusted for BMI	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, body mass index, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.041	0.0086	0.000002	-	27019061_fasting_glucose_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0403324	0.00848395	0.000002013601	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0384214	0.0080866	0.000002040818	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.0446414	0.009398	0.000002052431	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0391641	0.00825024	0.000002083751	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0794299	0.0167587	0.00000216144	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Chen Y	None	34670603	Oct 20, 2021	Waist Circumference	EFO_0004342	Multi-ethnic Asian meta-analysis	None	Waist Circumference	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	cm	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	94	19.9	0.0000022	None	34670603_Chen-Y_waist_circumference_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0401394	0.00849152	0.000002299727	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.052	0.011	0.0000023	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0462098	0.00977581	0.000002300331	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.179701	0.0380345	0.000002321992	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0417633	0.00884914	0.000002386415	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0389241	0.00825031	0.000002405011	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0389214	0.00825032	0.000002408837	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0403094	0.00854725	0.000002426593	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0388724	0.00825033	0.000002480114	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	OTC protein levels (SeqId = 15431-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OTC protein levels (SeqId = 15431-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ornithine carbamoyltransferase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	1.07	0.227	0.0000025	None	Gadd-DA_otc_protein_levels__seqid___15431-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0421791	0.00897691	0.000002643019	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	0.215941	0.0459642	0.000002645909	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0387345	0.00825038	0.000002691844	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.367567	0.0783108	0.000002702705	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0420354	0.0089575	0.00000271982	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.0387007	0.00825039	0.000002746209	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0386856	0.00825039	0.000002770922	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0386622	0.0082504	0.000002809653	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0427757	0.0091353	0.000002859922	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Concentration of small HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of small HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.0000029	None	Battram-T_concentration_of_small_hdl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0657434	0.0140492	0.000002901415	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0487867	0.0104321	0.000002942805	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0612567	0.013101	0.000002955316	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	ADIPOQ protein levels (SeqId = 3554-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADIPOQ protein levels (SeqId = 3554-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adiponectin	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-1.16	0.249	0.000003	None	Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0385073	0.00825045	0.000003078948	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0426161	0.00913391	0.000003102795	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.038454	0.00825046	0.00000317717	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0655602	0.014073	0.000003211826	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.0384214	0.00825048	0.000003238686	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0384115	0.00825048	0.000003257687	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0455552	0.00978601	0.000003266087	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.032	0.00697	0.0000033	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.036	0.008	0.0000033	-	28173150_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0389919	0.00838835	0.000003375296	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.182746	0.0393272	0.000003395686	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0825456	0.0177801	0.000003470709	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	10	2.1	0.0000036	None	Battram-T_triglycerides_in_medium_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0425983	0.0091906	0.000003600336	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0382291	0.00825054	0.000003625672	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TLL1 protein levels (SeqId = 6383-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TLL1 protein levels (SeqId = 6383-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tolloid-like protein 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.15	0.249	0.0000037	None	Gadd-DA_tll1_protein_levels__seqid___6383-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0386101	0.00834916	0.000003788331	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0380836	0.00825058	0.000003947722	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.245663	0.0533	0.00000401	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0380328	0.0082506	0.000004066377	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.038982	0.00849504	0.000004495119	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0378476	0.00825066	0.000004529091	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0378191	0.00825066	0.000004604377	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0378162	0.00825067	0.000004612232	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0689734	0.0150564	0.000004665495	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0377884	0.00825067	0.000004687054	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.055	0.012	0.0000048	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_hdl
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg09580077	chr17:17721930	17	17721930	SREBF1	Open sea	0.036	0.00791	0.0000048	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0377414	0.00825069	0.000004816502	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.225878	0.0493962	0.000004846277	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0643603	0.0140796	0.000004889854	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0576877	0.0126325	0.000004997273	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0376774	0.00825071	0.000004998075	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-0.0376451	0.00825072	0.000005092296	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.039	0.0085	0.0000051	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	1.177533	0.2584	0.00000518	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0375618	0.00825074	0.000005343018	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.177724	0.0390735	0.000005440541	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.037514	0.00825076	0.000005492119	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0406796	0.0089503	0.000005536003	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0408685	0.00899453	0.000005571627	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0380754	0.00838987	0.00000571708	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06287342	chr17:17721774	17	17721774	SREBF1	Open sea	-0.047717	0.0105147	0.000005720949	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0374269	0.00825079	0.000005774043	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.718	0.6	0.0000058	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0496103	0.0109408	0.000005821749	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0374119	0.00825079	0.000005824132	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0373962	0.0082508	0.000005876896	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0068	0.0015	0.0000059	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0379651	0.00838346	0.000005985048	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.234665	0.0518588	0.00000607551	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.290055	0.0641066	0.000006092174	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0630054	0.0139339	0.000006182046	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06261007	chr17:17740275	17	17740275	SREBF1	Island	0.00291	0.00063	0.0000062	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.13	0.249	0.0000062	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0423648	0.00937067	0.00000620309	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0384261	0.00850254	0.000006250916	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0372859	0.00825083	0.000006260428	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0595805	0.0131878	0.000006296294	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0372463	0.00825084	0.000006403725	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0372432	0.00825084	0.000006415332	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0372176	0.00825085	0.000006509711	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0379354	0.00841269	0.000006554255	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0571554	0.0126903	0.000006724137	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0371523	0.00825087	0.000006756841	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0483289	0.0107357	0.000006793115	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0497383	0.0110544	0.000006866658	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0697427	0.015502	0.000006881271	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0370719	0.0082509	0.000007073915	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0418647	0.00931919	0.000007099286	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.202823	0.0451636	0.000007140046	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0419885	0.00935247	0.000007191176	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0370201	0.00825091	0.000007285399	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0491621	0.0109584	0.000007304274	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0691447	0.0154166	0.000007344292	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0449624	0.0100253	0.000007350122	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0369883	0.00825092	0.000007418258	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0378136	0.00844036	0.000007517584	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.898953	0.2007	0.00000752	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0493879	0.011028	0.000007577111	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0371883	0.00830714	0.000007638765	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0440005	0.00982913	0.00000764353	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.040219	0.0089887	0.000007720471	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.0369027	0.00825095	0.000007787703	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.037571	0.00840165	0.00000781257	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0402448	0.00900091	0.000007836878	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0368855	0.00825095	0.000007863871	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0412736	0.00923322	0.000007875969	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Conjugated linoleic acid	EFO_0006807	None	None	DNA methylation	Conjugated linoleic acid	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	666	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	8.6	1.91	0.0000079	None	Battram-T_conjugated_linoleic_acid
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.076	0.01705	0.0000082	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0379775	0.00851441	0.000008242604	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0432663	0.00970209	0.000008276859	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.048615	0.0109094	0.000008402446	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0367055	0.00825101	0.000008706684	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0566314	0.0127361	0.000008790969	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.17262	0.0388352	0.000008846357	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0366528	0.00825102	0.000008968788	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0366491	0.00825102	0.0000089879	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15863539	chr17:17716950	17	17716950	SREBF1	South shore	-0.0044	0.00099	0.0000095	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0365462	0.00825106	0.000009523619	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	1.111066	0.2511	0.00000962	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0494035	0.0111695	0.000009801406	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0585691	0.013252	0.000009958287	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0684354	0.0154882	0.00001000718	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0364508	0.00825108	0.00001004721	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0364459	0.00825109	0.00001007486	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.141321	0.0320297	0.00001029577	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.247501	0.0560975	0.0000103051	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0363925	0.0082511	0.00001038097	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0422935	0.00959194	0.00001044571	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0741638	0.0168216	0.00001046628	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0482184	0.010945	0.00001062863	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0461954	0.0104972	0.00001086568	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.121131	0.0275	0.0000109	-	27105112_hiv_infection_neutrophils
Battram T	ARIES	None	2020-08-20	Total lipids in small HDL	EFO_0004529	None	None	DNA methylation	Total lipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.1	0.25	0.000011	None	Battram-T_total_lipids_in_small_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	CRELD1 protein levels (SeqId = 7628-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRELD1 protein levels (SeqId = 7628-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich with EGF-like domain protein 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.09	0.249	0.000011	None	Gadd-DA_creld1_protein_levels__seqid___7628-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0422044	0.00960601	0.0000112303	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0484572	0.0110369	0.0000113892	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0528089	0.01203	0.00001142637	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.036195	0.00825116	0.0000115909	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0361941	0.00825116	0.00001159676	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0361732	0.00825117	0.00001173228	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0482933	0.011023	0.00001188691	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.043	0.00974	0.000012	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Battram T	GEO	30045751	2020-09-15	Alzheimer's disease	EFO_0000249	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE66351	None	DNA methylation	Alzheimer's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Brain	Some brain tissue was cell sorted, but all data analysed together for this re-analysis of GEO data.	190	1	Geriatrics	Both	Unclear	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0386	0.00855	0.000012	None	30045751_Battram-T_alzheimer_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse66351
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.0413189	0.00943583	0.00001200834	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.043891	0.010035	0.00001229522	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.062927	0.0143904	0.00001234758	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0360681	0.0082512	0.00001243842	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.250001	0.0572082	0.00001249623	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0480666	0.0110022	0.00001257756	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg25999891	chr17:17724687	17	17724687	SREBF1	North shelf	0.216695	0.0496041	0.00001258299	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0360404	0.00825121	0.00001263135	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0360131	0.00825122	0.0000128239	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0359935	0.00825122	0.00001296414	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	9.6	2.2	0.000013	None	Battram-T_triglycerides_in_small_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0359761	0.00825123	0.00001308947	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0359601	0.00825123	0.00001320601	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.170856	0.0392097	0.00001323133	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	Regression coefficient per 1 SD of waist circumference	991	1	49	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0039	9e-04	0.0000133	-	25935004_waist_circumference_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0407992	0.00936621	0.00001333625	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	-0.0359386	0.00825124	0.00001336416	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0476807	0.0109476	0.00001337583	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	-0.035926	0.00825124	0.00001345711	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0359215	0.00825124	0.00001349084	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.036444	0.00837128	0.00001349132	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0358825	0.00825125	0.00001378479	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.035879	0.00825126	0.00001381166	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0609704	0.014022	0.00001381983	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.035858	0.00825126	0.00001397309	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0017	None	0.000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.26	0.29	0.000014	4808	31197173_Liu-J_fasting_glucose_base_plus_bmi
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.08	0.249	0.000014	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	-0.0369548	0.00851488	0.00001434202	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0358027	0.00825128	0.0000144056	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0364693	0.00840892	0.00001454217	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0396814	0.00915202	0.00001461942	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Kuan PF	-	28654093	2017-07-27	Major depressive disorder	EFO_0007634	Adjusted for dust cloud exposure	Table S2	DNA methylation	Major depressive disorder	Age, smoking, ethnicity, dust cloud exposure and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	398	1	50	Males	European,Other	cg16657453	chr17:17735704	17	17735704	SREBF1	North shelf	0.556	0.1283	0.0000147	-	28654093_major_depressive_disorder_adjusted_for_dust_cloud_exposure
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0357552	0.00825129	0.00001478814	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0357361	0.0082513	0.00001494455	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Chen Y	None	34670603	Oct 20, 2021	Body mass index	EFO_0004340	Multi-ethnic Asian meta-analysis	None	Body mass index	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	kg/m2	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	35.2	8.1	0.000015	None	34670603_Chen-Y_body_mass_index_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0357124	0.0082513	0.00001514061	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.035705	0.00825131	0.00001520213	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0553477	0.0127915	0.00001522061	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0356762	0.00825132	0.0000154451	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0388982	0.00899814	0.00001549964	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0550879	0.0127485	0.00001562674	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0356495	0.00825132	0.00001567274	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0356397	0.00825133	0.00001575762	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0772082	0.0178793	0.00001582591	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0708922	0.016433	0.0000161369	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	-0.0562126	0.0130381	0.00001632879	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0355623	0.00825135	0.00001644084	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.035545	0.00825135	0.00001659714	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0479079	0.0111324	0.00001692483	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0354631	0.00825138	0.00001735792	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.133251	0.0310152	0.00001746213	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.035421	0.00825139	0.00001776201	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0354003	0.0082514	0.00001796402	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-0.0368635	0.00859547	0.00001808653	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0420702	0.00981538	0.00001829558	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0353484	0.00825141	0.00001847942	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0516108	0.0120524	0.00001862241	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0588004	0.0137344	0.00001870234	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0353219	0.00825142	0.00001874879	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Ratio of 18:2 linoleic acid to total fatty acids	EFO_0006807, EFO_0005110	None	None	DNA methylation	Ratio of 18:2 linoleic acid to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.047	0.0109	0.000019	None	Battram-T_ratio_of_18_2_linoleic_acid_to_total_fatty_acids
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0059	None	0.000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0352905	0.00825143	0.00001907169	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.039279	0.00918933	0.00001928474	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0417355	0.00976785	0.00001943043	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.24495	0.0573406	0.00001949069	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gervin K	-	28785368	2017-08-02	Attention deficit hyperactivity disorder	EFO_0003888	Long-term prenatal exposure to paracetamol versus controls	Table S1	DNA methylation	Long-term prenatal exposure to paracetamol in children with ADHD versus controls	Sex, smoking, maternal age, gestational age, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	115	1	0	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-	-	0.0000195	-	28785368_attention_deficit_hyperactivity_disorder_longterm_prenatal_exposure_to_paracetamol_versus_controls
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0399573	0.00936347	0.00001990376	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0024	0.00053	0.00002	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0351891	0.00825146	0.00002015228	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.047874	0.0112263	0.00002016607	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0582792	0.0136762	0.00002044533	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0351368	0.00825147	0.00002073232	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0351324	0.00825147	0.00002078109	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0351302	0.00825148	0.00002080649	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0351259	0.00825148	0.00002085522	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0357229	0.00839188	0.00002086279	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	1.049947	0.2467	0.0000209	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0539854	0.0126838	0.00002091714	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	-0.0351177	0.00825148	0.00002094738	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Nuotio ML	FINRISK, NFBC1966	33239708	2020-12-14	Metabolic Sydnrome	EFO_0000195	Discovery	Supplmentary table 1	DNA methylation	Metabolic Sydnrome	age, sex, smoking, alcohol consumption, cell composition (reference based), batch effects, ancestry (genomic PCs)	M Values	None	Illumina HumanMethylation450	Whole blood	No CpGs replicated	517	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.06689	0.016	0.000021	None	33239708_Nuotio-ML_metabolic_sydnrome_discovery
Battram T	ARIES	None	2020-08-20	Phospholipids in small HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.71	0.4	0.000021	None	Battram-T_phospholipids_in_small_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	PCNA protein levels (SeqId = 19364-163)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCNA protein levels (SeqId = 19364-163)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proliferating cell nuclear antigen	774	1	Adults (18-65 years)	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-1.05	0.248	0.000021	None	Gadd-DA_pcna_protein_levels__seqid___19364-163__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06619462	chr17:17721208	17	17721208	SREBF1	Open sea	-0.212322	0.0499039	0.000021045	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0382047	0.00899944	0.00002197107	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	1.95	0.456	0.000022	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	0.179896	0.0424326	0.0000225053	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.27235672	0.06429	0.0000227	-	26798409_hypertriglyceridemic_waist
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.034952	0.00825153	0.00002291016	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Osteoarthritis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Osteoarthritis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	16114	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.071	0.01685	0.000023	None	Robert-F-Hillary_Incident_Osteoarthritis_Basic_model
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.123	0.029	0.000023	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0392623	0.00927745	0.00002330131	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0100365	0.0023731	0.0000235	-	28213390_serum_triglycerides_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0348858	0.00825155	0.00002374259	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TLR4 protein levels (SeqId = 11101-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TLR4 protein levels (SeqId = 11101-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Toll-like receptor 4	774	1	Adults (18-65 years)	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-1.048	0.248	0.000024	None	Gadd-DA_tlr4_protein_levels__seqid___11101-18__somascan_protein_measurement
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0307	0.0071	0.000024	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0348325	0.00825156	0.000024434	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0652674	0.0154645	0.00002452557	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.046624	0.0110489	0.00002460127	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0348044	0.00825157	0.00002480548	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0348782	0.00827176	0.00002495673	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.064398	0.0152745	0.00002501081	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	0.0377304	0.00895922	0.00002553689	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0347501	0.00825158	0.00002553917	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0347461	0.00825159	0.00002559417	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0358271	0.00851072	0.00002573007	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.056638	0.0134661	0.00002615053	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0411612	0.00979324	0.00002649358	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.130665	0.0311112	0.00002683417	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0346245	0.00825162	0.00002731728	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0412418	0.00982981	0.0000273773	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0391676	0.0093379	0.00002751064	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0495473	0.0118159	0.00002765787	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0346013	0.00825163	0.0000276582	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0345968	0.00825163	0.00002772433	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	-0.0415021	0.00989962	0.00002777734	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Battram T	GEO	26743604	2020-09-15	Psoriasis	EFO_0000676	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE73894	None	DNA methylation	Psoriasis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Skin	None	219	1	Adults	Both	Unclear	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0885	0.0206	0.000028	None	26743604_Battram-T_psoriasis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse73894
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.0008	None	0.000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-1.8	0.429	0.000028	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0345522	0.00825143	0.00002837929	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0345421	0.00825164	0.00002854589	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0392239	0.00937061	0.00002857645	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	0.0428673	0.0102487	0.00002897349	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0377963	0.00903891	0.00002912598	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0586737	0.0140338	0.00002920837	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0490357	0.0117389	0.00002968475	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.034453	0.00825167	0.00002993469	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FBP1 protein levels (SeqId = 7206-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBP1 protein levels (SeqId = 7206-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-1,6-bisphosphatase 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.04	0.249	0.00003	None	Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0012	None	0.00003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	0.0000304	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0587044	0.0140771	0.00003060735	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08323893	chr17:17727208	17	17727208	SREBF1	Island	-0.00006	0.000015	0.000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	0.0360059	0.00864896	0.0000315841	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0640201	0.0154009	0.00003244271	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0349422	0.00840984	0.00003272497	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0342799	0.00825172	0.00003281684	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0342745	0.00825172	0.00003291055	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.034268	0.00825172	0.00003302416	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0457257	0.0110114	0.0000330594	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0533306	0.0128447	0.00003315178	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.05443	0.0131136	0.00003334135	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.0499988	0.0120519	0.00003363477	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.0382518	0.00922106	0.0000336833	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0456631	0.0110125	0.0000339553	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21020221	chr17:17721180	17	17721180	SREBF1	Open sea	0.0342133	0.00825174	0.00003399542	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.00024542	5.9e-05	0.0000342	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.033	0.00804	0.000035	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0341575	0.00825175	0.00003501245	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-0.18045	0.0435981	0.00003505535	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0341197	0.00825176	0.00003571845	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05666074	chr17:17727281	17	17727281	SREBF1	Island	0.00086	None	0.000036	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.097	0.023	0.000036	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0397031	0.00960674	0.00003602916	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	0.0341026	0.00825177	0.00003604157	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0340625	0.00825178	0.00003681155	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0456329	0.0110548	0.00003681176	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.15	0.0356	0.000037	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0340276	0.00825179	0.000037495	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.034018	0.00825179	0.00003768531	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0421647	0.010228	0.00003769098	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0339982	0.0082518	0.00003807967	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0339966	0.0082518	0.0000381119	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	-0.0587147	0.0142519	0.00003812971	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0339254	0.00825182	0.00003956332	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.369337	0.0899	0.0000398	None	27105112_hiv_infection_cd4_tcells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0045	0.0011	0.00004	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.033881	0.00825183	0.00004049684	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0338801	0.00825183	0.00004051537	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.00464	0.00117742	0.0000406	-	28811542_age
Gadd DA	Generation Scotland	35945220	31/07/2022	SPTLC1 protein levels (SeqId = 7886-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPTLC1 protein levels (SeqId = 7886-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine palmitoyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.81	0.197	0.000041	None	Gadd-DA_sptlc1_protein_levels__seqid___7886-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0338225	0.00825185	0.00004175669	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BDNF protein levels (SeqId = 14047-78)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDNF protein levels (SeqId = 14047-78)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Brain-derived neurotrophic factor	774	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-1.33	0.325	0.000042	None	Gadd-DA_bdnf_protein_levels__seqid___14047-78__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0428809	0.0104656	0.0000420242	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0338095	0.00825185	0.00004204266	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06287342	chr17:17721774	17	17721774	SREBF1	Open sea	0.0337931	0.00825186	0.00004240543	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0429298	0.0104854	0.00004258453	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0337804	0.00825186	0.00004268781	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0337699	0.00825186	0.00004292142	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	0.0337596	0.00825187	0.00004315282	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0337504	0.00825187	0.00004336181	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0337312	0.00825187	0.00004379824	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	0.0428027	0.0104723	0.00004388877	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	0.160282	0.0392205	0.00004395413	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFBP2 protein levels (SeqId = 8469-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFBP2 protein levels (SeqId = 8469-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-1.17	0.287	0.000044	None	Gadd-DA_igfbp2_protein_levels__seqid___8469-41__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg13891611	chr17:17719813	17	17719813	SREBF1	South shelf	-0.160698	0.0393482	0.00004445652	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.033697	0.00825188	0.00004458711	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0329967	0.0080805	0.00004459899	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMK protein levels (SeqId = 9545-156)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMK protein levels (SeqId = 9545-156)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme K	774	1	Adults (18-65 years)	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.81	0.198	0.000045	None	Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0587538	0.0144049	0.00004552219	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0454665	0.0111562	0.00004616622	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13721589	chr17:17716006	17	17716006	SREBF1	Island	-0.0336136	0.00825191	0.00004656873	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0454026	0.0111486	0.00004675501	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Ratio of omega 6 fatty acids to total fatty acids	EFO_0005110	None	None	DNA methylation	Ratio of omega 6 fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.047	0.0115	0.000047	None	Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21020221	chr17:17721180	17	17721180	SREBF1	Open sea	-0.0335811	0.00825191	0.00004736349	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0960139	0.0236008	0.00004761469	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0570899	0.0140376	0.00004788751	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	-0.0335595	0.00825192	0.00004789632	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18748898	chr17:17721239	17	17721239	SREBF1	Open sea	-0.160855	0.0395929	0.00004870948	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0340935	0.00840055	0.00004964962	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.178899	0.0440947	0.00004988403	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0448433	0.0110554	0.00005012627	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0334712	0.00825195	0.00005014311	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13639244	chr17:17717006	17	17717006	SREBF1	South shore	0.0342375	0.0084434	0.00005040489	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0730698	0.0180246	0.0000506352	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0334232	0.00825196	0.00005140629	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.024	0.00593	0.000052	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.0380306	0.00939899	0.00005231329	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0333829	0.00825197	0.00005249008	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.033375	0.00825197	0.00005270665	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09580077	chr17:17721930	17	17721930	SREBF1	Open sea	-0.149894	0.0370728	0.00005293504	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.039	0.00961	0.000053	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.269917	0.0667752	0.00005318924	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0418692	0.0103618	0.00005355715	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0448116	0.0110947	0.00005395559	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0519693	0.0128692	0.00005412232	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0333108	0.00825199	0.00005448409	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0515335	0.0127718	0.000054895	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CBL protein levels (SeqId = 12016-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBL protein levels (SeqId = 12016-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase CBL	774	1	Adults (18-65 years)	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.8	0.197	0.000055	None	Gadd-DA_cbl_protein_levels__seqid___12016-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0332921	0.00825199	0.00005501331	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0332792	0.008252	0.00005538074	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.033278	0.008252	0.00005541417	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.033276	0.008252	0.00005547038	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	0.0055	None	0.000056	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09580077	chr17:17721930	17	17721930	SREBF1	Open sea	-0.0332499	0.00825201	0.0000562238	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.037681	0.00935353	0.00005640876	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-0.91	0.226	0.000057	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Ratio of triglycerides to phosphoglycerides	EFO_0004530, FMA_85433	None	None	DNA methylation	Ratio of triglycerides to phosphoglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	663	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.72	0.177	0.000057	None	Battram-T_ratio_of_triglycerides_to_phosphoglycerides
Gadd DA	Generation Scotland	35945220	31/07/2022	NOG protein levels (SeqId = 8778-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NOG protein levels (SeqId = 8778-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Noggin	774	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-1.312	0.326	0.000057	None	Gadd-DA_nog_protein_levels__seqid___8778-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0723201	0.0179699	0.00005738267	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.0341739	0.00849391	0.0000576651	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09580077	chr17:17721930	17	17721930	SREBF1	Open sea	-0.0331964	0.00825202	0.00005779493	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0394811	0.00981936	0.00005830622	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17029706	chr17:17721645	17	17721645	SREBF1	Open sea	0.0331566	0.00825203	0.00005898843	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	0.0331547	0.00825203	0.00005904617	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0441374	0.0109927	0.00005969968	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in VLDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.9	0.71	0.00006	None	33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	-0.0385899	0.00962137	0.00006079933	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0367873	0.00918287	0.00006204029	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	-0.0342731	0.00856002	0.00006262532	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0488305	0.0121969	0.00006271748	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0442258	0.0110514	0.00006316374	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0330215	0.00825207	0.00006322365	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0359429	0.00899527	0.0000648028	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22116239	chr17:17741676	17	17741676	SREBF1	North shore	-0.0329502	0.00825209	0.0000655719	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0449313	0.011264	0.00006669125	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.995	0.25	0.000067	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.055988	0.0140472	0.00006760444	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27407935	chr17:17723235	17	17723235	SREBF1	North shelf	0.0382362	0.0095952	0.00006782718	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.232793	0.0584489	0.00006836493	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Kuan PF	-	28654093	2017-07-27	Major depressive disorder	EFO_0007634	-	Table 3	DNA methylation	Major depressive disorder	Age, smoking, ethnicity and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	398	1	50	Males	European,Other	cg16657453	chr17:17735704	17	17735704	SREBF1	North shelf	0.454	0.1141	0.0000688	-	28654093_major_depressive_disorder
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16657453	chr17:17735704	17	17735704	SREBF1	North shelf	0.0011	None	0.000069	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PLEKHA7 protein levels (SeqId = 12731-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLEKHA7 protein levels (SeqId = 12731-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pleckstrin homology domain-containing family A member 7	774	1	Adults (18-65 years)	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.79	0.198	0.000069	None	Gadd-DA_plekha7_protein_levels__seqid___12731-12__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12244055	chr17:17715006	17	17715006	SREBF1	South shore	0.192071	0.0482558	0.00006910589	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0328354	0.00825212	0.00006953097	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PNPO protein levels (SeqId = 17804-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNPO protein levels (SeqId = 17804-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyridoxine-5'-phosphate oxidase	774	1	Adults (18-65 years)	Both	European	cg21099776	chr17:17739742	17	17739742	SREBF1	Island	-0.79	0.199	0.00007	None	Gadd-DA_pnpo_protein_levels__seqid___17804-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAH protein levels (SeqId = 11424-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAH protein levels (SeqId = 11424-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fumarylacetoacetase	774	1	Adults (18-65 years)	Both	European	cg14127237	chr17:17723462	17	17723462	SREBF1	North shelf	0.9	0.227	0.00007	None	Gadd-DA_fah_protein_levels__seqid___11424-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SFRP1 protein levels (SeqId = 3221-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SFRP1 protein levels (SeqId = 3221-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Secreted frizzled-related protein 1	774	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-1.29	0.326	0.00007	None	Gadd-DA_sfrp1_protein_levels__seqid___3221-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	0.032819	0.00825212	0.0000701136	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	0.0328031	0.00825213	0.00007068295	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	-0.0328024	0.00825213	0.00007071012	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0476472	0.011993	0.00007133508	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.062	0.0156	0.000072	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg03641529	chr17:17716218	17	17716218	SREBF1	Island	-0.00287	0.00072	0.000074	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0103	0.00257	0.000074	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	0.0371447	0.00937195	0.00007424313	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0326993	0.00825216	0.00007451384	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21020221	chr17:17721180	17	17721180	SREBF1	Open sea	-0.0326901	0.00825216	0.00007486555	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0326708	0.00825216	0.00007560074	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	-0.0609222	0.0153907	0.0000758144	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20155005	chr17:17722624	17	17722624	SREBF1	Open sea	-0.032663	0.00825217	0.00007589881	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COX5A protein levels (SeqId = 18226-148)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COX5A protein levels (SeqId = 18226-148)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytochrome c oxidase subunit 5A, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-1.29	0.325	0.000076	None	Gadd-DA_cox5a_protein_levels__seqid___18226-148__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0326542	0.00825217	0.00007624061	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0371681	0.00939835	0.00007697694	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	KLK14 protein levels (SeqId = 15544-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLK14 protein levels (SeqId = 15544-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kallikrein-14	774	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-1.29	0.326	0.000077	None	Gadd-DA_klk14_protein_levels__seqid___15544-25__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0371614	0.00939759	0.00007710422	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.0326225	0.00825218	0.00007747688	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07097265	chr17:17727093	17	17727093	SREBF1	Island	0.0325946	0.00825218	0.00007857568	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0370542	0.00938383	0.00007893273	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	-0.81	0.205	0.000079	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0325789	0.00825219	0.00007920336	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	-0.0679166	0.0172145	0.00008006432	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0391502	0.00992448	0.00008023487	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0325387	0.0082522	0.00008083101	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.0325371	0.0082522	0.00008089591	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	None	None	0.000081	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18666552	chr17:17722503	17	17722503	SREBF1	Open sea	-0.0406552	0.0103224	0.00008236396	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0524354	0.0133253	0.00008357208	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07097265	chr17:17727093	17	17727093	SREBF1	Island	0.00749	0.00186	0.000084	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0473313	0.0120326	0.00008406819	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0324593	0.00825222	0.00008413804	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07324110	chr17:17728004	17	17728004	SREBF1	South shore	-0.0329687	0.00838348	0.00008442768	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23875758	chr17:17715520	17	17715520	SREBF1	North shore	-0.0324485	0.00825222	0.00008459698	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03963689	chr17:17739407	17	17739407	SREBF1	North shore	-0.0321123	0.00816695	0.00008463705	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	0.0324096	0.00825223	0.00008627251	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFLR1 protein levels (SeqId = 7244-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFLR1 protein levels (SeqId = 7244-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: IGF-like family receptor 1	774	1	Adults (18-65 years)	Both	European	cg14808739	chr17:17741098	17	17741098	SREBF1	South shore	-0.85	0.217	0.000087	None	Gadd-DA_igflr1_protein_levels__seqid___7244-16__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15996882	chr17:17715815	17	17715815	SREBF1	Island	0.214872	0.0547492	0.00008716971	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1583	2	57	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002286	5.83e-05	0.0000872	-	28213390_serum_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10415767	chr17:17726759	17	17726759	SREBF1	North shore	-0.0323764	0.00825224	0.00008772548	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0323716	0.00825224	0.00008793777	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-LDL-FC_pct	None	Meta-analysis	Table S2	DNA methylation	L-LDL-FC_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Free cholesterol to total lipids ratio in large LDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.28	0.072	0.000088	None	33413638_Gomez-Alonso-MDC_l-ldl-fc_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0360165	0.0091953	0.00009012374	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0432599	0.0110477	0.00009053473	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0539952	0.0137923	0.00009085523	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0431261	0.0110163	0.00009091005	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	APOA5 protein levels (SeqId = 15363-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOA5 protein levels (SeqId = 15363-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein A-V	774	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	0.89	0.226	0.000091	None	Gadd-DA_apoa5_protein_levels__seqid___15363-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0366897	0.00937353	0.00009111976	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03340410	chr17:17738850	17	17738850	SREBF1	North shore	-0.0322985	0.00825226	0.00009122764	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0426849	0.0109105	0.00009183767	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0424998	0.0108666	0.00009231786	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17353846	chr17:17724021	17	17724021	SREBF1	North shelf	-0.0317168	0.0081099	0.00009237786	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.0322666	0.00825227	0.00009269946	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	-0.0322657	0.00825227	0.0000927455	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26588076	chr17:17741631	17	17741631	SREBF1	North shore	0.0549843	0.0140692	0.0000934309	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00525875	chr17:17722183	17	17722183	SREBF1	Open sea	0.0322457	0.00825228	0.00009367779	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	0.0322457	0.00825228	0.00009367842	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Glucose	EFO_0004468	None	None	DNA methylation	Glucose	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.28	0.071	0.000094	None	Battram-T_glucose
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03628186	chr17:17739914	17	17739914	SREBF1	Island	0.0322346	0.00825228	0.0000942017	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q14520	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q14520	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	0.043194	0.0110602	0.00009450808	Q14520	41361833_Josephine_Robertson_Q14520_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11637976	chr17:17716852	17	17716852	SREBF1	South shore	0.244563	0.0626296	0.00009460074	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09796270	chr17:17721594	17	17721594	SREBF1	Open sea	-0.0322174	0.00825229	0.00009501829	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UBB protein levels (SeqId = 6641-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBB protein levels (SeqId = 6641-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polyubiquitin-B	774	1	Adults (18-65 years)	Both	European	cg12631853	chr17:17727095	17	17727095	SREBF1	Island	0.86	0.221	0.000096	None	Gadd-DA_ubb_protein_levels__seqid___6641-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16928487	chr17:17741425	17	17741425	SREBF1	North shore	0.0603312	0.0154636	0.00009603069	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	-0.0545083	0.0139741	0.00009635808	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Alanine	EFO_0009765	None	None	DNA methylation	Alanine	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg08129017	chr17:17728660	17	17728660	SREBF1	South shore	1.4	0.35	0.000097	None	Battram-T_alanine
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23155675	chr17:17721834	17	17721834	SREBF1	Open sea	0.183846	0.0471802	0.00009788721	None	39706196_Hannah-M.-Smith_bmi_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	GPR107 protein levels (SeqId = 12963-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPR107 protein levels (SeqId = 12963-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein GPR107	774	1	Adults (18-65 years)	Both	European	cg16912637	chr17:17720273	17	17720273	SREBF1	Open sea	-0.97	0.248	0.000098	None	Gadd-DA_gpr107_protein_levels__seqid___12963-1__somascan_protein_measurement