author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05509697	chr22:42229062	22	42229062	SREBF2	Island	-0.000094	0.00001	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25932461	chr22:42229068	22	42229068	SREBF2	Island	-0.000056	0.0000065	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27479400	chr22:42228998	22	42228998	SREBF2	Island	0.00053	0.000059	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.56598	0.00954	6.9e-126	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.753767	0.0315728	4.543339e-124	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.16315	0.00294	1.7999999999999998e-120	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.11302	0.00239	3.6e-108	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.693882	0.0315244	5.452954000000001e-106	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.589802	0.0294327	2.246245e-88	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.536306	0.0267948	3.571258e-88	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.521907	0.0268979	4.988458e-83	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.42106	0.0247576	2.270763e-64	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.138319	0.00817721	1.3913319999999998e-63	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.590209	0.0363499	7.15535e-59	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.132241	0.00818406	3.152349e-58	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.161213	0.0103364	2.103612e-54	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.125754	0.00819103	8.741375000000001e-53	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.125307	0.00819149	2.024882e-52	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.615015	0.0420847	4.292999e-48	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.1414	0.00978752	5.514421000000001e-47	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.150739	0.0106097	1.647999e-45	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.114021	0.00820272	1.191566e-43	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.113856	0.00820288	1.5769180000000002e-43	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.112276	0.00820437	2.275742e-42	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.111332	0.00820524	1.100535e-41	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.110684	0.00820584	3.2228869999999996e-41	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.107687	0.00820856	4.2626950000000006e-39	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.106872	0.00820928	1.572449e-38	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.106705	0.00829746	1.2081459999999999e-37	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.106167	0.00825587	1.214461e-37	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.106186	0.00828455	2.081374e-37	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.104919	0.008211	3.440376e-37	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.102754	0.00821287	9.843691e-36	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.367398	0.0294186	1.204342e-35	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.368709	0.0295306	1.251123e-35	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.123679	0.0101135	3.190867e-34	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0997358	0.0082154	9.399294e-34	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.104108	0.00865737	3.7423460000000005e-33	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.104012	0.00865456	4.0793540000000006e-33	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0970057	0.00821763	5.160143e-32	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.474944	0.0413379	1.901158e-30	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.15	0.0128	2.4000000000000002e-30	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0942309	0.00821983	2.697402e-30	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0895968	0.00790601	1.199931e-29	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0930715	0.00822073	1.361745e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.13047	0.0117591	1.718852e-28	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.423518	0.0381929	1.751589e-28	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.090364	0.00822279	5.521952e-28	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0891605	0.0081261	6.681484000000001e-28	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.273593	0.024963	7.273733000000001e-28	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.113306	0.0103771	1.197815e-27	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0893857	0.00822352	2.048663e-27	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0882137	0.00822438	9.66933e-27	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0876809	0.00822477	1.944674e-26	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.304452	0.0286515	2.692728e-26	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.120065	0.0114746	1.5621840000000001e-25	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0885833	0.00847584	1.776719e-25	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0855212	0.00822632	3.162029e-25	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0854821	0.00822635	3.323879e-25	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.104381	0.0100783	4.745523e-25	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0848102	0.00822682	7.800367e-25	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0843112	0.00822717	1.463426e-24	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0837655	0.00822755	2.899871e-24	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.419528	0.0414635	5.318848e-24	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0830819	0.00822803	6.788341e-24	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0825794	0.00822837	1.2627790000000001e-23	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0823245	0.00822855	1.7276590000000002e-23	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0819567	0.0082288	2.711036e-23	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0813019	0.00822924	6.016493e-23	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0844196	0.00857073	8.088203000000001e-23	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0809116	0.0082295	9.646695000000001e-23	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0804288	0.00821009	1.369525e-22	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.08008	0.00823006	2.618375e-22	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.283178	0.0295626	1.102795e-21	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.131984	0.0138854	2.300789e-21	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0780794	0.0082913	5.319382e-21	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0767029	0.00815407	5.864969e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.340429	0.0363976	9.47925e-21	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0769365	0.0082321	1.039964e-20	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.095477	0.0102573	1.482156e-20	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0759389	0.00823273	3.244967e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0794867	0.00863382	3.8198389999999997e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0749858	0.00815263	4.140125e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.385594	0.0420725	5.470292e-20	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.11	0.0119	5.5e-20	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16170490	chr22:42302146	22	42302146	SREBF2	North shelf	0.02176	0.00212	5.6e-20	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0749275	0.00823336	1.01325e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0742233	0.0082338	2.219146e-19	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.074079	0.00823389	2.60354e-19	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0739537	0.00823396	2.9898809999999997e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0738018	0.00822453	3.2192019999999997e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.567345	0.0635651	4.87712e-19	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0898656	0.0100762	5.2738929999999995e-19	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0787193	0.00883088	5.490023999999999e-19	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0785386	0.00882927	6.500336e-19	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.3377	0.0380812	8.128010999999999e-19	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.072304	0.00823496	1.811048e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0723987	0.00826445	2.1586860000000002e-18	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0719168	0.00823519	2.748078e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0761948	0.00873062	2.885587e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0717281	0.0082353	3.3644840000000002e-18	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0714565	0.00823547	4.498116e-18	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0711045	0.00823567	6.543344e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.394757	0.04575	6.714134e-18	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.12	0.0135	6.9e-18	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0707487	0.00823588	9.538942e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.244927	0.0285892	1.1444730000000001e-17	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0701477	0.00823623	1.795344e-17	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.12023	0.0142456	3.472738e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0693015	0.00823672	4.335213e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0690598	0.00823686	5.565635e-17	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0689072	0.00823695	6.513768000000001e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.310967	0.037369	9.291007e-17	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.068064	0.00823742	1.544116e-16	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.056	0.00566	2e-16	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0676756	0.00823764	2.289689e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.521394	0.0640017	3.997649e-16	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0661801	0.00823847	0.000000000000001022678	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0874216	0.0108879	0.000000000000001054833	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0810284	0.0101564	0.000000000000001596043	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0653573	0.00823892	0.000000000000002297506	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0653118	0.00823894	0.000000000000002402027	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0646568	0.00817948	0.000000000000002875056	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.11	0.0138	0.0000000000000035	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.064885	0.00823917	0.000000000000003639926	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0788539	0.0100276	0.000000000000003989771	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0779922	0.00992213	0.0000000000000040938	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.046	0.00496	0.0000000000000044	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0656183	0.00835826	0.000000000000004422129	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0628783	0.00808505	0.000000000000007912331	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0638819	0.00823971	0.000000000000009567188	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0637829	0.00823976	0.00000000000001051646	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0643548	0.00831727	0.00000000000001080023	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0636482	0.00823983	0.00000000000001195766	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.220582	0.0287569	0.00000000000001798019	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0627705	0.00824029	0.00000000000002743776	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0626086	0.00824037	0.00000000000003194075	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.062807	0.00829246	0.00000000000003835152	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0621967	0.00824059	0.0000000000000469383	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.289038	0.0384224	0.000000000000056167	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0618956	0.00824074	0.00000000000006208975	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	0.01281	0.0017	0.0000000000000747	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0642522	0.00865104	0.0000000000001171151	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.352636	0.0475199	0.0000000000001218142	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0610609	0.00824117	0.0000000000001339304	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0604587	0.00820572	0.0000000000001826079	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.0606061	0.00824139	0.0000000000002027434	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.333448	0.0455983	0.0000000000002726324	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0014	0.00019	0.00000000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0600621	0.00824167	0.0000000000003315669	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0600096	0.00824169	0.000000000000347608	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0600037	0.00824169	0.0000000000003494649	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0599517	0.00824172	0.0000000000003661796	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0746845	0.0102964	0.0000000000004265741	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0596923	0.00824185	0.000000000000462115	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0596487	0.00824187	0.0000000000004804947	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0595499	0.00824192	0.0000000000005248313	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.189397	0.0262179	0.0000000000005248486	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0595325	0.00824193	0.0000000000005330578	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0594456	0.00824197	0.0000000000005759994	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.075871	0.0105542	0.0000000000006858116	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.193845	0.0271048	0.000000000000889607	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0587687	0.00827254	0.000000000001267116	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0732824	0.0103201	0.000000000001296327	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0710819	0.0100838	0.000000000001881094	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0581016	0.00824262	0.000000000001883562	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0579973	0.00824267	0.000000000002062765	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0727012	0.0103507	0.000000000002254064	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0578691	0.00824273	0.000000000002305772	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0737863	0.0105273	0.000000000002504335	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0577022	0.00824281	0.000000000002665002	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0608345	0.00871785	0.00000000000311935	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13637042	chr22:42228724	22	42228724	SREBF2	Island	-0.00019	0.000028	0.0000000000032	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0603851	0.00866761	0.000000000003381722	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.41e-05	7.8e-06	0.00000000000367	-	28213390_serum_total_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0572169	0.00824305	0.00000000000404985	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.086	0.0124	0.0000000000042	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0570047	0.00824315	0.000000000004857907	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0647573	0.00939245	0.000000000005622231	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg25937494	chr22:42228971	22	42228971	SREBF2	Island	0.00611	9e-04	0.00000000000664	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0615104	0.00896718	0.000000000007186616	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0592124	0.00863711	0.00000000000738631	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0581032	0.00848452	0.000000000007778671	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.34e-05	7.8e-06	0.00000000000825	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0612923	0.00896673	0.000000000008493484	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-1.2	0.177	0.0000000000095	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0562703	0.00826614	0.00000000001032905	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.200521	0.0295107	0.00000000001119523	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0559753	0.00824363	0.00000000001163383	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0557361	0.00824374	0.00000000001422019	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23067438	chr22:42228994	22	42228994	SREBF2	Island	0.00042	0.000062	0.000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0556078	0.0082438	0.00000000001583084	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0551975	0.00824398	0.0000000000222771	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0551611	0.008244	0.00000000002295815	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0550993	0.00824403	0.00000000002416446	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0550448	0.00824405	0.00000000002527991	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0575311	0.00862633	0.00000000002663388	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0614547	0.0092188	0.00000000002718368	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0549269	0.00824411	0.00000000002786822	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0567159	0.00852534	0.00000000002981012	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.259748	0.0390963	0.00000000003143266	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0546985	0.00824421	0.00000000003363932	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M32492_caprylate_8:0	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32492_caprylate_8:0	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	15.4	0.18	0.000000000037	None	24014485_Petersen-A-K_m32492_caprylate_8_0_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0545466	0.00824428	0.00000000003810594	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0541993	0.00824444	0.00000000005062114	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0539342	0.00824455	0.00000000006279613	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0538984	0.00824457	0.00000000006464739	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0555635	0.00851243	0.0000000000691495	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0536968	0.00824466	0.00000000007610232	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0535609	0.00824472	0.00000000008492093	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0535478	0.00824473	0.00000000008582051	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0558191	0.0085973	0.00000000008706391	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0581352	0.00896677	0.00000000009254708	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0517947	0.007995	0.00000000009566712	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0533689	0.0082448	0.00000000009910293	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0552149	0.00853427	0.000000000101254	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0532911	0.00824484	0.0000000001054874	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0662248	0.0102635	0.0000000001135276	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.053171	0.00824489	0.0000000001161412	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.047	0.00735	0.00000000013	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0529759	0.00824498	0.0000000001357305	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0631034	0.00983609	0.0000000001446724	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.250453	0.0391915	0.0000000001693446	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0663542	0.010396	0.0000000001792452	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M32492_caprylate_8:0	EFO_0004727, EFO_0004725	no snps model	Table S2	M32492_caprylate_8:0	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	13.3	0.18	0.00000000019	None	24014485_Petersen-A-K_m32492_caprylate_8_0_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0525318	0.00824517	0.0000000001931276	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0524761	0.0082452	0.0000000002018266	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0524252	0.00824522	0.000000000210105	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.052362	0.00824524	0.0000000002208429	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.182882	0.0288425	0.0000000002340522	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0522342	0.0082453	0.0000000002442249	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0521957	0.00824532	0.0000000002517182	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0518908	0.00824545	0.0000000003196966	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0518328	0.00824547	0.0000000003345146	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0517816	0.00824549	0.0000000003481429	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0652806	0.0103996	0.0000000003544125	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.0515771	0.00824558	0.0000000004082328	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07746918	chr22:42229324	22	42229324	SREBF2	Island	0.00021	0.000033	0.00000000043	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.204622	0.0327605	0.0000000004309489	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0535266	0.00857092	0.0000000004350874	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.03	0.00489	0.00000000053	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0646284	0.0104193	0.0000000005697893	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.295533	0.0476515	0.000000000570268	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0511292	0.00824577	0.0000000005773505	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0515258	0.00831718	0.0000000005980219	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0544929	0.00879701	0.0000000006004346	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0510757	0.00824579	0.0000000006016523	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0513016	0.00830652	0.0000000006745396	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0508294	0.0082459	0.0000000007269208	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0508177	0.0082459	0.0000000007334935	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.382674	0.0621458	0.0000000007536601	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0626569	0.0101786	0.0000000007665905	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0507213	0.00824594	0.0000000007896309	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0515187	0.00837918	0.0000000008028668	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0541641	0.0088114	0.0000000008097982	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0514883	0.00839104	0.000000000867416	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0489919	0.00798583	0.0000000008742877	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-	-	0.000000000916	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0529297	0.00864135	0.0000000009290468	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0504791	0.00824605	0.0000000009499427	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0503996	0.00824608	0.000000001009149	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0503964	0.00824608	0.000000001011608	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0681514	0.0111542	0.000000001021991	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0503208	0.00824611	0.000000001071402	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0502853	0.00824613	0.000000001100602	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0529042	0.00868034	0.000000001123813	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	0.387235	0.0636123	0.000000001170349	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0501025	0.0082462	0.000000001263984	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0495548	0.0081565	0.000000001266669	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0503384	0.00829971	0.000000001351336	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0508886	0.00840284	0.000000001428502	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0524714	0.00866566	0.000000001437569	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0523426	0.00867971	0.000000001674349	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0505828	0.00839421	0.000000001721871	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0496412	0.00824639	0.000000001788478	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.74e-05	9.5e-06	0.00000000179	-	28213390_serum_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0496378	0.00824639	0.000000001793164	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.0495569	0.00824643	0.000000001904973	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0515118	0.00857227	0.000000001909501	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0494693	0.00824646	0.000000002033969	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0622421	0.010405	0.000000002255939	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0504342	0.00843693	0.000000002314323	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0492912	0.00824654	0.000000002322586	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0496794	0.0083196	0.000000002407058	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0492411	0.00824656	0.000000002410894	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0517313	0.00867015	0.000000002478366	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0491966	0.00824657	0.000000002491855	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.66e-05	9.5e-06	0.00000000303	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0523387	0.00882708	0.000000003110135	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0492671	0.00830927	0.000000003113076	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0488791	0.0082467	0.000000003152333	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0488479	0.00824672	0.000000003225663	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0472633	0.00799419	0.000000003450559	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.0487303	0.00824676	0.000000003517752	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0599102	0.0101388	0.00000000351784	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0795458	0.0134902	0.000000003792851	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0505947	0.00859094	0.000000003963069	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0485489	0.00824684	0.000000004019123	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0494533	0.00842961	0.000000004543686	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.050681	0.00866384	0.000000005029211	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04477345	chr22:42292872	22	42292872	SREBF2	Open sea	-0.290961	0.0497455	0.000000005030035	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0482219	0.00824697	0.000000005104549	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0480871	0.00824702	0.000000005630782	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.37156	0.063829	0.000000005946942	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0479964	0.00824706	0.000000006013983	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.085	0.0146	0.0000000061	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0479517	0.00824707	0.000000006212075	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.047915	0.00824709	0.000000006379662	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0483246	0.00833079	0.000000006738868	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.206848	0.0357128	0.000000007069994	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0477443	0.00824716	0.000000007217301	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.0477333	0.00824716	0.000000007275192	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0599022	0.0103615	0.000000007566187	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.047514	0.00822002	0.000000007609591	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0499995	0.00865553	0.000000007777153	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0480875	0.00832622	0.000000007831478	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.047574	0.00824722	0.000000008160025	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0475017	0.00824725	0.000000008594921	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0474538	0.00824727	0.000000008895923	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0474305	0.00824728	0.000000009045842	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0478536	0.00832769	0.000000009302008	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0498577	0.00869208	0.000000009885828	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0472884	0.00824733	0.0000000100148	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0472463	0.00824735	0.00000001032146	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.169475	0.0295897	0.00000001036104	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.047138	0.00824739	0.00000001115033	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0470862	0.00824741	0.00000001156993	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0500555	0.00877298	0.0000000118142	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0501084	0.00878341	0.00000001186655	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0470438	0.00824743	0.00000001192453	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.242341	0.0424907	0.00000001193713	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0470137	0.00824744	0.0000000121827	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0468765	0.00824749	0.00000001342975	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0468316	0.00824751	0.000000013864	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.046919	0.00827693	0.00000001466375	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0467314	0.00824755	0.00000001488388	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	4.91	0.867	0.000000015	-	28173150_serum_total_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0467049	0.00824756	0.00000001516487	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0466677	0.00824758	0.00000001556906	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	0.0465722	0.00824761	0.00000001665428	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0474772	0.00841739	0.00000001728168	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0500974	0.00889256	0.00000001797023	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0486709	0.00866847	0.00000002004672	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0462983	0.00824772	0.00000002019089	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0462585	0.00824773	0.00000002076219	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0468016	0.00834584	0.00000002086484	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0461612	0.00824777	0.00000002222382	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0461011	0.00824779	0.00000002317755	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0464552	0.00831126	0.00000002318796	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0459796	0.00824784	0.000000025227	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.156194	0.0280297	0.00000002549338	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.183674	0.0329805	0.0000000259795	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0552388	0.00991968	0.0000000261296	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0458155	0.0082479	0.00000002827459	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0573982	0.0103557	0.00000003030565	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0491339	0.00887049	0.00000003093938	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0456476	0.00824796	0.00000003176398	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0455999	0.00824798	0.00000003282906	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0455545	0.008248	0.00000003387344	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.205671	0.0372535	0.00000003419899	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.045936	0.00832683	0.00000003514325	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0454879	0.00826162	0.0000000373408	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0453686	0.00824807	0.00000003850201	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0453574	0.00824807	0.00000003880109	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.215939	0.0393529	0.00000004140052	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0451938	0.00824814	0.00000004341172	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0451276	0.00824816	0.00000004542562	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0564479	0.0103198	0.00000004578155	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.062508	0.0114492	0.0000000484974	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0450192	0.0082482	0.00000004891681	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.147254	0.0270117	0.0000000505906	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.044905	0.00824824	0.0000000528765	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0448817	0.00824825	0.00000005372486	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.073716	0.0135485	0.00000005386197	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0448454	0.00824826	0.00000005506813	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0447338	0.00824831	0.00000005940599	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0446861	0.00824832	0.00000006135686	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0450441	0.00832275	0.00000006324664	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0461934	0.00853561	0.00000006335782	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0446278	0.00824835	0.0000000638286	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0710517	0.0131585	0.00000006779321	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.044533	0.00824838	0.00000006805786	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0444797	0.0082484	0.0000000705529	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0448287	0.0083203	0.00000007239963	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0448713	0.00833665	0.00000007462319	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.206882	0.0384467	0.00000007498231	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0445956	0.00829033	0.00000007595449	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16170490	chr22:42302146	22	42302146	SREBF2	North shelf	-0.00048	0.00009	0.000000077	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0476422	0.00887391	0.00000008047348	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0442669	0.00824848	0.0000000814186	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.043233	0.00805942	0.00000008250616	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.04435	0.00826792	0.00000008258531	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0441037	0.00824854	0.00000009083646	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0440809	0.00824855	0.00000009223723	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.206079	0.0385707	0.00000009256778	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12767332	chr22:42271413	22	42271413	SREBF2	Open sea	-0.227967	0.0427399	0.00000009731356	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0439923	0.00824858	0.00000009786325	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0439078	0.00824861	0.0000001035387	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0438875	0.00824862	0.0000001049497	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0472998	0.00890064	0.0000001086946	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0436948	0.00824869	0.000000119301	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-	-	0.000000125	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0436966	0.00827222	0.0000001293735	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0543276	0.0102903	0.0000001313926	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0435402	0.00824874	0.0000001321721	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0435108	0.00824875	0.0000001347674	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0794439	0.0151076	0.0000001472531	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0527184	0.0100264	0.0000001477055	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg13637042	chr22:42228724	22	42228724	SREBF2	Island	0.0076	0.0014	0.000000149	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0538122	0.0102456	0.0000001523881	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0034	0.00064	0.00000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0432348	0.00824885	0.0000001616495	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.050444	0.00963396	0.0000001663091	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0452161	0.00865752	0.0000001786919	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0436851	0.00838321	0.0000001903429	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.044929	0.00862521	0.000000192405	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0428612	0.00824898	0.0000002064272	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0458271	0.00883951	0.0000002196599	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.198612	0.0383158	0.000000220045	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.094	0.0181	0.00000023	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0426703	0.00824905	0.0000002337107	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0425165	0.00822201	0.0000002358443	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0555773	0.0107514	0.0000002380771	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.053227	0.0102973	0.000000238435	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0425599	0.00824909	0.000000251048	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.043814	0.00849284	0.000000251598	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0429869	0.00833748	0.0000002557474	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0442313	0.00858564	0.0000002613856	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.0423143	0.00824918	0.0000002941863	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0423902	0.00826415	0.0000002943547	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0422994	0.00824918	0.000000297018	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0427938	0.00838352	0.0000003358003	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0420852	0.00824926	0.0000003408347	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.062388	0.0122669	0.0000003704343	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0419514	0.0082493	0.0000003712819	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0419017	0.00824932	0.0000003832495	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0418873	0.00824933	0.0000003867851	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.0420049	0.00827639	0.000000391687	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.126996	0.0251062	0.0000004270336	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0417163	0.00824938	0.0000004312559	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.0589763	0.0116692	0.0000004378714	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.023	0.00452	0.00000047	None	Robert-F-Hillary_Incident_COPD_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.141529	0.0280985	0.0000004779462	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0421157	0.00837502	0.0000004995902	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.041429	0.00824948	0.0000005173495	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0584016	0.0116463	0.0000005376706	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0416382	0.00831817	0.0000005630893	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0416553	0.00832963	0.000000577371	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0447875	0.00895774	0.0000005803346	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0430492	0.00861644	0.0000005915214	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0413247	0.00827897	0.0000006059205	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0415465	0.00832421	0.0000006074273	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0411655	0.00824957	0.0000006106499	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0410592	0.00824961	0.0000006527459	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0410583	0.00824961	0.0000006530803	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0649136	0.0130442	0.0000006549676	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.163275	0.0328667	0.0000006836681	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.0411491	0.00828333	0.0000006851508	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0409701	0.00824964	0.000000690139	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0409577	0.00824964	0.0000006955174	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0442252	0.00891156	0.0000007030765	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0430548	0.00869126	0.0000007358685	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.1472972	0.0297481	0.0000007365	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0670164	0.0135289	0.0000007366959	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0408276	0.00824969	0.0000007542712	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0407484	0.00824971	0.000000792357	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0407269	0.00824972	0.0000008030303	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0406905	0.00824973	0.0000008213759	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.0406748	0.00824974	0.0000008294464	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0406694	0.00824974	0.0000008322358	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0405946	0.00824977	0.0000008717448	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0405641	0.00824978	0.0000008883475	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.077054	0.015678	0.0000008984671	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.089	0.0181	0.0000009	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.092	0.0188	0.00000091	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	0.00748	0.00147	0.00000092	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0521155	0.0106341	0.0000009647965	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0404268	0.00824982	0.0000009670338	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0403787	0.00824984	0.0000009961431	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0403765	0.00824984	0.0000009974975	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0401685	0.00824991	0.000001133565	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0440165	0.00905068	0.000001166201	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.068	0.014	0.0000012	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0400025	0.00824996	0.000001254779	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0425354	0.00877979	0.000001281055	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0399661	0.00824997	0.000001282976	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0499135	0.0103121	0.000001309851	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0398421	0.00825002	0.000001383725	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0404395	0.00837961	0.000001407454	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0397797	0.00825004	0.000001437219	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0397739	0.00825004	0.000001442322	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0424914	0.00882408	0.000001483749	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0400509	0.00831926	0.000001492367	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0396943	0.00825006	0.000001513761	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27479400	chr22:42228998	22	42228998	SREBF2	Island	0.0019	0.00039	0.0000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-1.8	0.372	0.0000016	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0574203	0.0119758	0.00000164528	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0398203	0.00830622	0.000001650664	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0395495	0.00825011	0.000001652445	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0395115	0.00825012	0.000001690801	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0415761	0.00868425	0.000001704959	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0418789	0.00875189	0.00000172539	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0421927	0.00882147	0.000001744137	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0571491	0.011959	0.000001781071	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0413513	0.00867534	0.000001892174	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.133494	0.0280146	0.00000190254	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0393097	0.00825019	0.000001909463	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0391773	0.00825023	0.000002067336	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0547072	0.0115237	0.000002080445	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.06	0.0127	0.0000021	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0424303	0.0089415	0.000002101407	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0409173	0.00862337	0.000002105426	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0390878	0.00825026	0.000002181091	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.041646	0.00879103	0.000002185803	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0492523	0.0103967	0.000002186447	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0390044	0.00825029	0.000002292516	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0490757	0.0103917	0.000002350077	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0411381	0.00872962	0.000002469742	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0407015	0.00865858	0.00000261622	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0575361	0.0122527	0.00000267969	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0387179	0.00825038	0.000002718435	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23067438	chr22:42228994	22	42228994	SREBF2	Island	0.141852	0.0302821	0.000002828618	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-4.7	1.014	0.0000029	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0634493	0.0135609	0.000002910801	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05360632	chr22:42280865	22	42280865	SREBF2	Open sea	0.173401	0.0370665	0.000002917235	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0385885	0.00825042	0.000002934854	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0385874	0.00825042	0.000002936654	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0388695	0.00831387	0.000002962019	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0385551	0.00825043	0.00000299329	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0420352	0.00899849	0.000003018733	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg05509697	chr22:42229062	22	42229062	SREBF2	Island	1.04235	0.2235	0.00000309	-	27105112_hiv_infection_discovery
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-4.74	1.004	0.0000031	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0384546	0.00825046	0.000003175995	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0403553	0.0086755	0.000003321839	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.059895	0.012881	0.000003350223	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0383287	0.0082505	0.000003420094	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.0570625	0.0122991	0.000003521421	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.044	0.00953	0.0000036	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.038237	0.00825053	0.000003609009	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0383303	0.00827206	0.00000362278	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0381959	0.00825055	0.000003696849	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0389072	0.00840522	0.000003707117	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0381633	0.00825056	0.000003768062	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0386362	0.00835405	0.000003780877	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	4	None	0.0000038	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.038035	0.0082506	0.000004061194	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0468381	0.0101642	0.0000040974	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0379644	0.00825062	0.000004231787	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0379603	0.00825062	0.00000424199	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0378866	0.00825064	0.000004427608	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0374513	0.00816306	0.000004514283	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0381279	0.00832943	0.000004744361	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0371918	0.00813585	0.00000488565	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0416009	0.00910733	0.000004967762	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.194477	0.0426349	0.00000511353	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0376125	0.00825073	0.000005188908	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.0376122	0.00825073	0.000005189774	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0402657	0.00884066	0.000005290631	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0479224	0.0105277	0.000005356107	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0375472	0.00825075	0.000005388102	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0375292	0.00825076	0.000005444388	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0375058	0.00825076	0.000005518233	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0390874	0.00861423	0.00000573652	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0374221	0.00825079	0.00000579023	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0677919	0.0149522	0.000005835941	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0402979	0.00889082	0.000005874066	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.039607	0.00875796	0.000006162123	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0379555	0.00839921	0.000006263754	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0399698	0.00885189	0.000006369179	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0390934	0.00866863	0.000006540725	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0425672	0.00944387	0.000006613752	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.0371823	0.00825086	0.000006642279	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.00027552	6.09e-05	0.00000682	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0403952	0.00897981	0.000006897719	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0370471	0.0082509	0.000007174405	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.069824	0.0155653	0.000007317159	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02039517	chr22:42280570	22	42280570	SREBF2	Open sea	0.1468	0.0327342	0.000007352093	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.036976	0.00825093	0.000007470207	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.045943	0.0102583	0.000007569634	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	0.053364	0.0119213	0.000007650103	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0369196	0.00825094	0.000007713172	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0369095	0.00825095	0.000007757502	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0368832	0.00825095	0.000007874359	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.036806	0.00825098	0.000008225842	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0371075	0.0083194	0.000008242996	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0367943	0.00825098	0.000008280709	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12767332	chr22:42271413	22	42271413	SREBF2	Open sea	0.196231	0.0440075	0.00000828453	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0367614	0.00825099	0.000008435814	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	0.15145	0.0339964	0.000008446526	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0523778	0.0117734	0.000008697181	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.024	0.00532	0.0000087	None	Robert-F-Hillary_Incident_COPD_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	0.259054	0.0582484	0.000008743073	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.036686	0.00825101	0.000008802735	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	8.997	2.026	0.000009	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0362365	0.00816132	0.000009060595	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0477539	0.010784	0.000009569782	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0392953	0.00888138	0.000009738055	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0365018	0.00825107	0.000009763721	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0390394	0.00884744	0.00001029087	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0363612	0.00825111	0.00001056396	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg13637042	chr22:42228724	22	42228724	SREBF2	Island	-0.959439	0.2179	0.0000106	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0389728	0.00884973	0.00001071044	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0363011	0.00825113	0.00001092511	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.188192	0.0427825	0.00001094965	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0376547	0.00856463	0.0000110767	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0362695	0.00825114	0.00001111948	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0362139	0.00825116	0.00001146986	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0357078	0.00814762	0.00001180858	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.034678	0.00791288	0.00001181581	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0382354	0.00873081	0.00001198498	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB6 protein levels (SeqId = 5078-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB6 protein levels (SeqId = 5078-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 6	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.68	0.154	0.000012	None	Gadd-DA_ephb6_protein_levels__seqid___5078-82__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.039	0.00881	0.000012	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0467083	0.010667	0.00001201756	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0422463	0.00964942	0.0000120539	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0386155	0.00882197	0.00001210432	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0361022	0.00825119	0.0000122048	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	0.0360399	0.00825121	0.00001263485	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0360213	0.00825121	0.00001276557	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.01	0.0023	0.000013	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0399174	0.00915237	0.00001301008	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.0360228	0.00827367	0.00001346411	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.0359222	0.00825124	0.00001348592	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0359109	0.00825125	0.00001357064	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.188023	0.0432075	0.00001359036	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0387845	0.00891352	0.00001363097	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0368803	0.00848338	0.00001387171	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	HMGCS1 protein levels (SeqId = 13496-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HMGCS1 protein levels (SeqId = 13496-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.64	0.147	0.000014	None	Gadd-DA_hmgcs1_protein_levels__seqid___13496-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.0358459	0.00825127	0.00001406621	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.039481	0.00909522	0.00001428872	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0589578	0.0135872	0.00001439457	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0358038	0.00825128	0.00001439695	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	3.183	0.736	0.000015	-	28173150_serum_total_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0357061	0.00825131	0.000015193	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0357023	0.00825131	0.00001522493	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0357016	0.00825131	0.00001523066	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0356894	0.00825131	0.00001533348	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0375624	0.00869639	0.00001575492	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0374989	0.00868867	0.00001600387	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0355526	0.00825135	0.00001652821	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0355499	0.00825135	0.00001655326	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0354944	0.00825137	0.00001706327	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0356371	0.00829255	0.00001738676	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0392342	0.00913217	0.00001748222	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	0.0353838	0.0082514	0.0000181269	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0353749	0.0082514	0.00001821478	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0353516	0.00825141	0.00001844746	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0430807	0.0100618	0.00001867191	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0353211	0.00825142	0.00001875659	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0353045	0.00825142	0.00001892641	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.087	0.0204	0.000019	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0383236	0.00896382	0.00001920346	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0352773	0.00825143	0.0000192091	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0352598	0.00825144	0.00001939252	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0352497	0.00825144	0.00001949947	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0352217	0.00825145	0.0000197985	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.058	0.0136	0.00002	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.106698	0.0250257	0.00002022361	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0372617	0.00874712	0.00002058099	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0359059	0.00843278	0.00002076401	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0351217	0.00825148	0.00002090286	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NEGR1 protein levels (SeqId = 7050-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEGR1 protein levels (SeqId = 7050-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuronal growth regulator 1	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.657	0.154	0.000021	None	Gadd-DA_negr1_protein_levels__seqid___7050-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.0385716	0.00906841	0.00002118504	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0578448	0.0136181	0.00002173744	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0368265	0.00867012	0.00002174865	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0350326	0.0082515	0.00002193476	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.13	0.0311	0.000022	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	0.037387	0.00881152	0.00002219432	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.035009	0.00825151	0.00002221607	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0349837	0.00825152	0.00002252247	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17157956	chr22:42273901	22	42273901	SREBF2	Open sea	0.112467	0.0265377	0.00002266821	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0349546	0.00825153	0.0000228782	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-1.9	0.453	0.000023	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0378938	0.00894928	0.00002306718	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0348751	0.00825155	0.00002387978	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.69	0.163	0.000024	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UNC5B protein levels (SeqId = 7776-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UNC5B protein levels (SeqId = 7776-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Netrin receptor UNC5B	774	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	-0.37	0.088	0.000024	None	Gadd-DA_unc5b_protein_levels__seqid___7776-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0493433	0.01168	0.00002408302	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0350496	0.00830025	0.00002428351	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0347188	0.00822209	0.00002429304	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.037987	0.00900062	0.00002452353	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	-0.027	0.0063	0.000025	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	HMOX1 protein levels (SeqId = 17398-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HMOX1 protein levels (SeqId = 17398-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heme oxygenase 1	774	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.77	0.184	0.000025	None	Gadd-DA_hmox1_protein_levels__seqid___17398-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0347748	0.00825158	0.00002520345	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0358602	0.00850916	0.0000252055	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0571471	0.0135611	0.00002523417	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0511988	0.012151	0.00002528818	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0321165	0.00762805	0.00002565277	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0347381	0.00825159	0.00002570423	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0428117	0.0101724	0.00002584621	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0376993	0.00896525	0.00002625788	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0376443	0.00895328	0.00002631811	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.051142	0.012171	0.00002661842	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0376728	0.00896924	0.00002682256	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0346135	0.00825162	0.00002747846	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0346131	0.00825162	0.00002748404	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0346026	0.00825163	0.00002763816	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0372398	0.0088854	0.00002792097	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0417751	0.00996832	0.00002796183	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0440335	0.0105194	0.00002856396	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0345406	0.00825164	0.0000285695	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.034505	0.00825165	0.00002911599	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0344645	0.00825167	0.00002975144	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0442285	0.0105895	0.00002975357	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0346919	0.00830772	0.00002985717	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.164647	0.0394575	0.00003023894	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	0.0344207	0.00825168	0.00003045297	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0344197	0.00825168	0.00003046913	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0370706	0.00888739	0.00003048106	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.0348928	0.00836605	0.00003053329	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	0.0361286	0.00866886	0.00003095423	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Replication adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	3.995	0.959	0.000031	-	28173150_serum_total_cholesterol_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0491468	0.0117966	0.00003115406	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0343742	0.00825169	0.00003121575	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.034331	0.0082517	0.00003193904	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-1.1	0.268	0.000032	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.040017	0.0096352	0.00003296995	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0348857	0.00840456	0.00003331845	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0342254	0.00825173	0.00003377717	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0342058	0.00825174	0.00003413085	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0360977	0.00871552	0.00003465661	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.192095	0.0463845	0.00003467962	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27479400	chr22:42228998	22	42228998	SREBF2	Island	0.125879	0.0304345	0.00003548852	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0370847	0.00896713	0.00003559523	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0341052	0.00825177	0.0000359918	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05360632	chr22:42280865	22	42280865	SREBF2	Open sea	-0.0342294	0.00828488	0.00003623232	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0340731	0.00825178	0.00003660722	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0429599	0.0104087	0.00003690932	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0340545	0.00825178	0.00003696709	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	0.0340084	0.0082518	0.00003787468	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05836598	chr22:42294680	22	42294680	SREBF2	Open sea	-0.0341087	0.00828221	0.00003837455	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.0345005	0.0083816	0.00003872477	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0339577	0.00825181	0.00003889931	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0353536	0.00859256	0.00003902407	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0478215	0.0116283	0.00003935108	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05360632	chr22:42280865	22	42280865	SREBF2	Open sea	-0.146922	0.0357495	0.00003977952	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ST6GALNAC5 protein levels (SeqId = 7927-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ST6GALNAC5 protein levels (SeqId = 7927-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	774	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.98	0.238	0.00004	None	Gadd-DA_st6galnac5_protein_levels__seqid___7927-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0338858	0.00825183	0.00004039384	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0504758	0.0122952	0.00004059588	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0368212	0.00897396	0.0000409821	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05836598	chr22:42294680	22	42294680	SREBF2	Open sea	-0.0338195	0.00825185	0.00004182208	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	0.107878	0.0263345	0.00004213426	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0367411	0.0089734	0.00004254441	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.133992	0.0327314	0.00004264352	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	TAPBPL protein levels (SeqId = 6364-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAPBPL protein levels (SeqId = 6364-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tapasin-related protein	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.63	0.154	0.000043	None	Gadd-DA_tapbpl_protein_levels__seqid___6364-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0340144	0.00831257	0.0000430095	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0337506	0.00825187	0.00004335791	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0337491	0.00825187	0.00004339012	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05836598	chr22:42294680	22	42294680	SREBF2	Open sea	-0.0338488	0.00829127	0.00004479671	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Inflammatory Bowel Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Inflammatory Bowel Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17959	1	Adults (18-65y)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.022	0.00546	0.000045	None	Robert-F-Hillary_Incident_Inflammatory_Bowel_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0424705	0.0104076	0.00004513327	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.0336721	0.00825189	0.00004517105	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-0.160312	0.0393376	0.00004616215	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.043741	0.0107353	0.00004635605	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	KLK11 protein levels (SeqId = 2831-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLK11 protein levels (SeqId = 2831-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kallikrein-11	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.628	0.154	0.000047	None	Gadd-DA_klk11_protein_levels__seqid___2831-29__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	-1.4	0.336	0.000047	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0352447	0.0086617	0.00004745686	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0518964	0.0127552	0.00004753294	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21282452	chr22:42232160	22	42232160	SREBF2	South shelf	-0.0337644	0.00831134	0.00004881277	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.1020159	0.0251373	0.00004942	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0349152	0.00860287	0.00004963359	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0334889	0.00825194	0.00004968732	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.040692	0.0100281	0.00004979265	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TREML2 protein levels (SeqId = 5736-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREML2 protein levels (SeqId = 5736-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trem-like transcript 2 protein	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.63	0.154	0.000051	None	Gadd-DA_treml2_protein_levels__seqid___5736-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0336023	0.00829556	0.00005134066	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0348598	0.00861033	0.00005178837	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0362434	0.00895211	0.00005179385	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.0333958	0.00825197	0.00005214193	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	0.0333817	0.00825197	0.00005252454	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0480786	0.0119	0.00005367025	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0455796	0.0112815	0.00005367444	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0333397	0.00825198	0.00005367603	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0348537	0.00864548	0.0000557169	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-0.65	0.161	0.000056	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg20107653	chr22:42228989	22	42228989	SREBF2	Island	-0.170949	0.0425	0.0000566	-	27105112_hiv_infection_neutrophils
Gadd DA	Generation Scotland	35945220	31/07/2022	GRN protein levels (SeqId = 4992-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GRN protein levels (SeqId = 4992-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Progranulin	774	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	-0.36	0.088	0.000057	None	Gadd-DA_grn_protein_levels__seqid___4992-49__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	0.257556	0.0639864	0.00005716569	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.037771	0.00938643	0.00005750466	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.0332032	0.00825202	0.00005759235	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RPN1 protein levels (SeqId = 6458-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPN1 protein levels (SeqId = 6458-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.62	0.154	0.000058	None	Gadd-DA_rpn1_protein_levels__seqid___6458-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.6	0.149	0.000058	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0331678	0.00825203	0.00005864957	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0341122	0.00848716	0.00005867085	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	0.0333474	0.00830659	0.00005985019	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Soerensen M	Middle-Aged Danish Twins	32327964	2020-04-09	Cognitive function	EFO_0003925, EFO_0008354	None	Table S3a	DNA methylation	Cognitive function	Sex, age, cell composition (reference based), ancestry (genomic PCs)	M Values	cognitive composite score	Illumina HumanMethylation450	Whole blood	Analysis of twins	452	1	Adults	Both	European	cg16170490	chr22:42302146	22	42302146	SREBF2	North shelf	0.01337	0.00327	0.00006	None	32327964_Soerensen-M_cognitive_function
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0629562	0.0156886	0.00006028383	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.0520658	0.0129984	0.00006217515	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0430458	0.0107654	0.00006404365	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	-0.0329581	0.00825209	0.00006531037	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.143167	0.0358511	0.00006539642	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.0329417	0.00825209	0.00006585952	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	-1.87	0.465	0.000066	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.0555954	0.0139296	0.00006606764	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DPEP1 protein levels (SeqId = 8794-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DPEP1 protein levels (SeqId = 8794-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dipeptidase 1	774	1	Adults (18-65 years)	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	-0.82	0.205	0.000067	None	Gadd-DA_dpep1_protein_levels__seqid___8794-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KRT20 protein levels (SeqId = 12975-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KRT20 protein levels (SeqId = 12975-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Keratin, type I cytoskeletal 20	774	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.58	0.147	0.000067	None	Gadd-DA_krt20_protein_levels__seqid___12975-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0379596	0.00952134	0.0000672984	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02458785	chr22:42293245	22	42293245	SREBF2	Open sea	0.0328904	0.0082521	0.00006760784	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Ribs bone mineral density	EFO_0007591	None	None	DNA methylation	Ribs bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	702	1	Adults	Females	European	cg07746918	chr22:42229324	22	42229324	SREBF2	Island	1.35	0.34	0.000068	None	Battram-T_ribs_bone_mineral_density
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	0.0344385	0.00865082	0.00006897101	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23227119	chr22:42290034	22	42290034	SREBF2	Open sea	-0.0340568	0.008555	0.00006897762	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	-0.0328439	0.00825212	0.00006923051	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	0.0330215	0.00829944	0.00006960765	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	-0.0345039	0.00867384	0.00006985416	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.0419524	0.0105588	0.0000712462	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.021	0.00517	0.000072	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	TFF3 protein levels (SeqId = 4721-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TFF3 protein levels (SeqId = 4721-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trefoil factor 3	774	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	-0.35	0.089	0.000073	None	Gadd-DA_tff3_protein_levels__seqid___4721-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26613723	chr22:42228508	22	42228508	SREBF2	Island	-0.0326857	0.00825216	0.0000750311	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GNS protein levels (SeqId = 3616-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNS protein levels (SeqId = 3616-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-acetylglucosamine-6-sulfatase	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.61	0.154	0.000078	None	Gadd-DA_gns_protein_levels__seqid___3616-3__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg12856612	chr22:42228819	22	42228819	SREBF2	Island	-0.235101	0.0595	0.0000782	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0341889	0.00865448	0.00007837701	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL12 protein levels (SeqId = 3516-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL12 protein levels (SeqId = 3516-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 1	774	1	Adults (18-65 years)	Both	European	cg02320600	chr22:42243577	22	42243577	SREBF2	Open sea	0.76	0.194	0.00008	None	Gadd-DA_cxcl12_protein_levels__seqid___3516-60__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	-0.116433	0.0295138	0.00008009859	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0325157	0.00825221	0.00008177545	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	-0.0325094	0.00825221	0.00008203512	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.0346701	0.00880158	0.00008217602	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	0.194345	0.049369	0.00008296195	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27535047	chr22:42228699	22	42228699	SREBF2	Island	0.00088	0.00022	0.000084	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	-0.0335717	0.0085394	0.00008484231	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	0.0340414	0.00865997	0.00008502133	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.032369	0.00825224	0.00008805116	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	0.0328275	0.00837308	0.00008873113	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0323424	0.00825225	0.0000892387	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05836598	chr22:42294680	22	42294680	SREBF2	Open sea	-0.0337193	0.00861558	0.00009128075	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.040771	0.0104205	0.00009173522	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.0325575	0.00832699	0.00009275729	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11012487	chr22:42240675	22	42240675	SREBF2	Open sea	0.037098	0.0094893	0.00009292096	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	WISP1 protein levels (SeqId = 13692-154)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WISP1 protein levels (SeqId = 13692-154)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WNT1-inducible-signaling pathway protein 1	774	1	Adults (18-65 years)	Both	European	cg00830626	chr22:42229212	22	42229212	SREBF2	Island	-0.602	0.154	0.000093	None	Gadd-DA_wisp1_protein_levels__seqid___13692-154__somascan_protein_measurement
Sharp G	PACE	33517419	2021-01-29	Maternal body mass index	EFO_0004340	Adjusted for paternal BMI using cord blood in males only	https://osf.io/ebtw7/	DNA methylation	Maternal body mass index	paternal bmi, cell composition (reference based), batch effects, maternal age, paternal age, maternal smoking during pregnancy, paternal smoking during or prior to pregnancy, socio-economic position and maternal parity	Beta Values	kg/m2	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Cord blood	Probes that were common to both arrays were included in the meta-analysis	2530	13	Infants	Males	European, Admixed, South Asian	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.00221	0.00057	0.000094	None	33517419_Sharp-G_maternal_body_mass_index_adjusted_for_paternal_bmi_using_cord_blood_in_males_only
Gadd DA	Generation Scotland	35945220	31/07/2022	LARGE protein levels (SeqId = 7935-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LARGE protein levels (SeqId = 7935-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: LARGE xylosyl- and glucuronyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg16351433	chr22:42258538	22	42258538	SREBF2	Open sea	-0.935	0.24	0.000094	None	Gadd-DA_large_protein_levels__seqid___7935-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09347991	chr22:42294630	22	42294630	SREBF2	Open sea	-0.0322328	0.00825228	0.0000942883	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	0.0322317	0.00825228	0.00009433568	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10826400	chr22:42258288	22	42258288	SREBF2	Open sea	0.0336094	0.00861117	0.00009543211	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TAGLN protein levels (SeqId = 15640-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TAGLN protein levels (SeqId = 15640-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transgelin	774	1	Adults (18-65 years)	Both	European	cg06382651	chr22:42235793	22	42235793	SREBF2	Open sea	-0.34	0.088	0.000097	None	Gadd-DA_tagln_protein_levels__seqid___15640-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02114066	chr22:42244821	22	42244821	SREBF2	Open sea	-0.032176	0.0082523	0.00009700731	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04682183	chr22:42292183	22	42292183	SREBF2	Open sea	-0.0321683	0.0082523	0.00009738125	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01162866	chr22:42241482	22	42241482	SREBF2	Open sea	0.0321632	0.0082523	0.00009763153	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05608063	chr22:42269725	22	42269725	SREBF2	Open sea	-0.0321614	0.0082523	0.00009771636	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19027130	chr22:42242382	22	42242382	SREBF2	Open sea	-0.0342809	0.00879616	0.00009771942	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12403973	chr22:42230899	22	42230899	SREBF2	South shore	-0.033517	0.00860422	0.00009846632	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.032137	0.00825231	0.00009891854	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	-0.057	0.0145	0.000099	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PAF protein levels (SeqId = 19158-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAF protein levels (SeqId = 19158-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PCNA-associated factor	774	1	Adults (18-65 years)	Both	European	cg15128785	chr22:42230879	22	42230879	SREBF2	South shore	0.57	0.146	0.000099	None	Gadd-DA_paf_protein_levels__seqid___19158-1__somascan_protein_measurement