author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	-0.002	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23961922	chr3:133538989	3	133538989	SRPRB	Open sea	0.59798	0.00926	1.1999999999999999e-132	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.54447	0.00874	1e-129	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.33893	0.00693	1.1000000000000001e-110	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.175037	0.00810586	7.890785e-102	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.172404	0.00809236	3.2878570000000003e-99	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.171628	0.0080818	1.3395e-98	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.170955	0.00813503	1.271178e-96	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.170833	0.00813334	1.580005e-96	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.172317	0.00828986	1.325604e-94	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.167184	0.00809529	1.991915e-93	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.166724	0.00814101	6.298564e-92	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.166542	0.0081462	1.2769579999999998e-91	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.163253	0.00809777	3.525095e-89	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.163084	0.00814846	6.182181e-88	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.162689	0.00814657	1.450608e-87	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	0.1968	0.00698	2.2e-70	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.08988	0.0043	1.9e-51	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20390545	chr3:133527210	3	133527210	SRPRB	South shelf	0.0871	0.00519	1.6e-39	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	-	-	9.56e-32	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.0843693	0.00826607	2.232985e-24	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.0843013	0.00828343	3.021986e-24	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.0818622	0.00822437	2.8822330000000005e-23	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.0816705	0.00822618	3.7168050000000003e-23	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17952877	chr3:133502677	3	133502677	SRPRB	Island	-0.0813678	0.00822919	5.554374e-23	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.0812229	0.00822929	6.62127e-23	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.0809173	0.0082321	9.879738000000001e-23	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02414224	chr3:133502623	3	133502623	SRPRB	Island	-0.0806429	0.00823359	1.396118e-22	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.0819596	0.00846468	4.1670550000000004e-22	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.0763486	0.00823247	2.0373189999999998e-20	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.0762008	0.0082322	2.4014109999999998e-20	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03760072	chr3:133502685	3	133502685	SRPRB	Island	-0.0760938	0.00823406	2.763091e-20	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0693649	0.00821105	3.246075e-17	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0689678	0.00823691	6.119829e-17	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0689594	0.00826094	7.580895000000001e-17	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0012	None	8.8e-17	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0708792	0.0088084	9.149646e-16	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0743695	0.00934862	0.000000000000001919793	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	-0.0191	0.00256903	0.0000000000000524	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.065966	0.00877096	0.00000000000005752729	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0650813	0.00873042	0.00000000000009521953	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13072611	chr3:133524485	3	133524485	SRPRB	North shore	-0.00019	0.000025	0.00000000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0600898	0.00824165	0.0000000000003233967	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg20106907	chr3:133525036	3	133525036	SRPRB	Island	-1.869096	0.26	0.000000000000651	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0569228	0.00823559	0.000000000004982663	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0624255	0.00905732	0.000000000005715041	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06691279	chr3:133524569	3	133524569	SRPRB	Island	-0.00017	0.000025	0.00000000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0535531	0.00824472	0.00000000008545513	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0534572	0.00828235	0.0000000001121019	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg13072611	chr3:133524485	3	133524485	SRPRB	North shore	1.386027	0.2298	0.00000000163	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.049249	0.00824655	0.000000002396781	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0485469	0.00826839	0.000000004415276	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0483264	0.00826991	0.000000005215454	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	0.0519002	0.00890196	0.000000005652988	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	0.0467964	0.00824753	0.0000000142143	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg20106907	chr3:133525036	3	133525036	SRPRB	Island	0.01039	0.0019	0.0000000202	-	23334450_rheumatoid_arthritis
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	-	-	0.0000000333	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0449532	0.00824822	0.00000005116942	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0447528	0.0082483	0.00000005864191	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20390545	chr3:133527210	3	133527210	SRPRB	South shelf	-0.0017	0.00031	0.000000063	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15778365	chr3:133524658	3	133524658	SRPRB	Island	0.00468	0.00085	0.00000011	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13072611	chr3:133524485	3	133524485	SRPRB	North shore	0.01027	0.00191	0.00000021	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	-	-	0.000000436	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-0.0409318	0.00824965	0.0000007068437	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gruzieva H.	PACE	31148503	2019-05-31	Particulate matter <2.5um (PM2.5)	EFO_0008255	Discovery and replication	Table 3	DNA methylation	Particulate matter <2.5um (PM2.5)	Sex, maternal smoking, batch effects, ancestry (other)	Beta Values	um	Illumina HumanMethylation450	Cord blood	Some study specific covariates	1949	7	Infants	Both	European, other	cg24127244	chr3:133524572	3	133524572	SRPRB	Island	0.001	None	0.00000073	None	31148503_Gruzieva-H._particulate_matter__2_5um__pm2_5__discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0402385	0.00824988	0.000001085833	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12183955	chr3:133502302	3	133502302	SRPRB	North shore	0.0391254	0.00825025	0.00000213264	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model with smoking adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex, smoking	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	None	None	0.0000026	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment
Sharp GC	-	25855720	2015-08-01	Maternal underweight	EFO_0005936	Birth	Additional file 1	DNA methylation	Maternal underweight	Offspring sex, maternal age, maternal smoking, maternal occupation, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	601	1	0	Both	European	cg13072611	chr3:133524485	3	133524485	SRPRB	North shore	0.02037	0.00436	0.00000303	-	25855720_maternal_underweight_birth
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	None	None	0.0000032	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model without gestational weight gain adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	None	None	0.0000052	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_without_gestational_weight_gain_adjustment
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	None	None	0.0000059	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model with smoking adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, gestational weight gain, sex, smoking	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	None	None	0.0000059	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model with smoking adjustment and without gestational weight gain adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, sex, smoking	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	None	None	0.000006	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment_and_without_gestational_weight_gain_adjustment
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model without gestational weight gain adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	None	None	0.0000067	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_without_gestational_weight_gain_adjustment
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20390545	chr3:133527210	3	133527210	SRPRB	South shelf	0.013	0.0029	0.0000076	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0405266	0.00915264	0.000009586145	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	basic model with smoking adjustment and without gestational weight gain adjustment	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	maternal age, maternal prepregnancy body mass index, gestational age, sex, smoking	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	None	None	0.0000097	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_basic_model_with_smoking_adjustment_and_without_gestational_weight_gain_adjustment
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-1.030262	0.2333	0.0000101	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ZPBP2 protein levels (SeqId = 10710-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZPBP2 protein levels (SeqId = 10710-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zona pellucida-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-0.35	0.08	0.000015	None	Gadd-DA_zpbp2_protein_levels__seqid___10710-23__somascan_protein_measurement
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	adjustment only for sex and gestational age	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	gestational age, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg11941507	chr3:133524510	3	133524510	SRPRB	North shore	None	None	0.00002	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_adjustment_only_for_sex_and_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0350798	0.00825149	0.00002138161	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Jonsson J	Treatment of Obese Pregnant women study	33431374	2021-04-01	Physical activity and low-energy diet during pregnancy	EFO_0003940, EFO_0002755	adjustment only for sex and gestational age	Table S1	DNA methylation	Physical activity and low-energy diet during pregnancy	gestational age, sex	M Values	None	Illumina HumanMethylation450	Cord blood	Data comes from an RCT	208	1	Infants	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	None	None	0.000023	None	33431374_Jonsson-J_physical_activity_and_low-energy_diet_during_pregnancy_adjustment_only_for_sex_and_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB3 protein levels (SeqId = 9220-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB3 protein levels (SeqId = 9220-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 3	774	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-0.34	0.08	0.000024	None	Gadd-DA_ephb3_protein_levels__seqid___9220-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0397114	0.00945271	0.0000267241	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	0.0016	None	0.00003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-0.014	0.00338	0.000031	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20106907	chr3:133525036	3	133525036	SRPRB	Island	-0.0347678	0.0083557	0.00003187169	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	MAP3K3 protein levels (SeqId = 12990-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAP3K3 protein levels (SeqId = 12990-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase kinase kinase 3	774	1	Adults (18-65 years)	Both	European	cg15778365	chr3:133524658	3	133524658	SRPRB	Island	-0.64	0.155	0.000033	None	Gadd-DA_map3k3_protein_levels__seqid___12990-39__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0338049	0.00829149	0.00004584919	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-	-	0.0000465	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01672886	chr3:133525182	3	133525182	SRPRB	Island	0.0336003	0.00825191	0.00004689159	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.03339	0.00825197	0.00005229932	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15611150	chr3:133524362	3	133524362	SRPRB	North shore	-0.0332447	0.00825201	0.00005637497	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19821772	chr3:133529810	3	133529810	SRPRB	Open sea	-0.0331973	0.00825202	0.00005776744	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMK protein levels (SeqId = 9545-156)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMK protein levels (SeqId = 9545-156)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme K	774	1	Adults (18-65 years)	Both	European	cg20106907	chr3:133525036	3	133525036	SRPRB	Island	-0.74	0.184	0.00006	None	Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	0.0329111	0.00828864	0.00007202623	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16275903	chr3:133524006	3	133524006	SRPRB	North shore	-0.136241	0.0345407	0.00008031549	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F3	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	53	Both	European	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	-	-	0.0000861	-	26500701_sex_kora_f3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13053595	chr3:133527122	3	133527122	SRPRB	South shore	-0.01	0.0026	0.000095	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Prostate Cancer	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Prostate Cancer	Age, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	6084	1	Adults (18-65y)	Males	European	cg24127244	chr3:133524572	3	133524572	SRPRB	Island	0.038	0.00974	0.000097	None	Robert-F-Hillary_Incident_Prostate_Cancer_Fully-adjusted_model
Lunnon K	-	25129077	2014-08-17	Alzheimers disease Braak stage	EFO_0000249, EFO_0006801	Discovery in cerebellum	Table S6	DNA methylation	Alzheimers disease Braak stage	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Cerebellum	-	108	1	-	Missing	None	cg01409985	chr3:133524160	3	133524160	SRPRB	North shore	-	-	0.000098	-	25129077_alzheimers_disease_braak_stage_discovery_in_cerebellum